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Emerging Biopharma Master Class: State of the Payer 2024 - IQVIA

<!DOCTYPE html> <!--[if IE 9]><html lang="en" class="ie9 no-js"><![endif]--> <!--[if !IE]><!--> <html lang="en"> <!--<![endif]--> <head> <meta charset="utf-8" /> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta http-equiv="Content-type" content="text/html; charset=utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1, maximum-scale=1, user-scalable=no"> <meta name="msapplication-TileImage" content="/Content/Shotgun/img/favicon/ms-icon-144x144.png?v=4" /> <link rel="apple-touch-icon-precomposed" href="/Content/Shotgun/img/favicon/apple-icon-precomposed.png?v=4" /> <link rel="icon" href="/Content/Shotgun/img/favicon/favicon.ico?v=4" /><style> .coveo-card-layout a::after { display: none !important; } </style><!-- Google Tag Manager --> <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-P97VBCW');</script> <!-- End Google Tag Manager --><meta name="google-site-verification" content="EyIQB7GdOQ83t4xrzV8zE-Gs_mjfgD-VO1TZkSkbKSc" /><!-- No Custom Fonts --> <!-- BEGIN NOINDEX --> <title>Emerging Biopharma Master Class: State of the Payer 2024 - IQVIA</title> <!-- END NOINDEX --> <link rel="canonical" href="https://www.iqvia.com/locations/united-states/blogs/2024/07/emerging-biopharma-master-class-state-of-the-payer-2024" /> <meta name="keywords" content="blog, Emerging Biopharma Master Class, State of Payer 2024, Inflation Reduction Act, IRA, EBP, Modern Launch, GLP-1, 340B program, Dawn of a New Era, life sciences, payer controls" /> <meta name="description" content="Changes in brand launches, inflation reduction act, obesity treatments and gross margins are driving new challenges for emerging biopharma companies." /> <meta name="iq:related_solutions" content="Emerging Biopharma, Commercial Solutions, Market Access, Patient Services, Thought Leader Network" /> <meta name="iq:region" content="North America" /> <meta name="iq:regional_business_unit" content="US &amp; Canada" /> <meta name="iq:market_product" content="IQVIA" /> <meta name="iq:business_area" content="Safety and Regulatory Compliance,Enterprise" /> <meta name="iq:market_segment" content="Consumer Health,Emerging Biopharma (EBP),Payers" /> <meta name="iq:insight_topics" content="Commercial Compliance,Market Access,Patient Centricity,Digital Health,Orchestrated Customer Engagement,AI &amp; Machine Learning" /> <meta name="iq:buyer_journey" content="General Interest" /> <meta name="iq:thought_leadership" content="" /> <meta property="og:title" content="Emerging Biopharma Master Class: State of the Payer 2024" /> <meta property="twitter:title" content="Emerging Biopharma Master Class: State of the Payer 2024" /> <meta property="og:image" content="https://www.iqvia.com/-/media/iqvia/images/modules/brandworld/551-custom-photo-two-people-discussing-graph.jpg" /> <meta property="twitter:image" content="https://www.iqvia.com/-/media/iqvia/images/modules/brandworld/551-custom-photo-two-people-discussing-graph.jpg" /> <meta property="og:description" content="&lt;p&gt; The decade from 2014 to 2024 has brought significant changes to the life sciences industry. Pharma went into defensive mode as payers of all types introduced constraints on spend. Companies experienced declining launch returns alongside intense margin pressures. Given the rise in specialty treatments, more patients were navigating complex journeys &amp;mdash; driving significant investment into &lt;a href=&quot;~/link.aspx?_id=C1ED34E139F44508B407636D3D4E334F&amp;amp;_z=z&quot;&gt;patient support services&lt;/a&gt;.&lt;/p&gt; &lt;p&gt; As we look ahead to the next decade, we see a whole new set of dynamics at play, which includes impacts of the &lt;a href=&quot;~/link.aspx?_id=C28AFC3268244DCE8A6595E820893365&amp;amp;_z=z&quot;&gt;Inflation Reduction Act (IRA)&lt;/a&gt;, as well as blockbusters losing exclusivity, accelerating research and development activities, and growing evidence needs. Other forces of change include rising patient activism and consumerism, expanding metabolic treatments, evolving pricing strategies, and growing opportunities both technological (with advances in generative artificial intelligence) and geographical (as markets outside the U.S. become more important to success).&lt;/p&gt; &lt;p&gt; One thing is certain: What drove success in the decade behind won&amp;rsquo;t be effective in the one ahead.&lt;/p&gt; &lt;p&gt; In considering the State of the Payer 2024 for emerging biopharmas (EBPs), we have identified three key trends &amp;mdash; each with specific takeaways to help in shaping strategies for this brave new world.&lt;/p&gt; &lt;h4&gt; Trend #1: Plan for the &amp;lsquo;Modern Launch&amp;rsquo; &lt;/h4&gt; &lt;p&gt; IQVIA analysis found that from 2014 to 2023, the median annual cost of treatment at launch went up by 84% for non-oncology orphan treatments and 191% for oncology treatments. This finding reflects companies&amp;rsquo; changing pipelines and focus on narrower patient populations. It also illuminates why payers keep increasing controls to mitigate spend. &lt;/p&gt; &lt;p&gt; As we studied &lt;a href=&quot;~/link.aspx?_id=37E3FE0288CC422687F20A52D6CA99FE&amp;amp;_z=z&quot;&gt;brand launches&lt;/a&gt;, 2020 emerged as a turning point in terms of launch strategies and performance. Across nearly all therapeutic categories, post-pandemic launches consistently underperform pre-pandemic trends. While payers used to control costs more heavily at launch, they&amp;rsquo;re now limiting access gains into subsequent years, too. As a result, average launch efficiency decreased 12% from 2018 to 2023. In some cases, manufacturers are stepping in as primary payer to get a patient on therapy &amp;mdash; fully subsidizing as much as 90% of demand! In this new world, Modern Launch windows are 18 to 36 months, suggesting that brands need more time to gauge launch performance.&lt;/p&gt; &lt;h5&gt; How EBPs can adapt to the Modern Launch: &lt;/h5&gt; &lt;ul&gt; &lt;li&gt;More than 75% of launches are missing their first-year forecast &amp;mdash; suggesting an urgent need to reassess launch forecasting. &lt;/li&gt; &lt;li&gt;A longer launch means that investment needs to accelerate or to be maintained at higher levels for a longer period. EBPs need to be prepared to launch twice as fast or take twice as long. &lt;/li&gt; &lt;li&gt;Markets and prescribers are getting sensitized to large and generous manufacturer support programs. EBPs should plan to provide high levels of patient support while in launch mode.&lt;/li&gt; &lt;/ul&gt; &lt;h4&gt; Trend #2: Obesity is shaking the market &lt;/h4&gt; &lt;p&gt; Obesity is poised to become a top-five global market with a profound effect on spending across multiple areas. The first cohort of treatments has transformed the fortunes of Lilly and Novo Nordisk &amp;mdash; propelling them to #1 and #2, respectively, in market capitalization. Longer-term impacts are still taking shape. For now, payer control is high in &lt;a href=&quot;~/link.aspx?_id=6353A768D75C4BADADE4261DF06B0079&amp;amp;_z=z&quot;&gt;managing GLP-1 treatments&lt;/a&gt;. At the same time, more competition will be entering the market &amp;mdash; creating downward price pressures and a proliferation of options for consumers.&lt;/p&gt; &lt;p&gt; For patients with obesity, there is a direct correlation between age, body mass index (BMI), and the number of comorbidities. That means there will be profound effect on many classes of drugs as treatment expands to more patients. In the short term, more patients seeking weight-loss treatment could increase diagnosis of other diseases, driving demand for other therapeutic areas. But over the next decade, patients being treated for obesity could lead to lower demand for drugs in therapeutic areas like diabetes, cardiovascular disease, immunology, oncology, and kidney disease.&lt;/p&gt; &lt;h5&gt; What all brands can learn from the GLP-1 launches: &lt;/h5&gt; &lt;ul&gt; &lt;li&gt;Consumerism drove significant demand. Tapping into consumer motivation can drive early patient volumes &amp;mdash; making patient awareness and advocacy keys to success. &lt;/li&gt; &lt;li&gt;Obesity treatments have direct and indirect impacts on many therapeutic areas. In the short term, overlapping comorbidities can create tailwinds. But over the long term, obesity treatments will create headwinds. &lt;/li&gt; &lt;li&gt;Healthcare providers who embraced GLP-1s are demonstrative of early adopters of a modern launch. EBPs should understand who is adopting and where to gain insights into prescriber behavior and promotional influence.&lt;/li&gt; &lt;/ul&gt; &lt;h4&gt; Trend #3: Margin challenges are expanding &lt;/h4&gt; &lt;p&gt; A decade ago, retail branded drug gross margins were around 70%; as of 2022, the average was nearly halved to just 37%. There are many contributing factors beyond payer control and rebate pressure. Industry wide, copay offset costs have doubled since 2018, with pharma spending $23.1 billion on copay cards and debit costs in 2023. The &lt;a href=&quot;~/link.aspx?_id=A0D1FA83524E44478BDAF4E89E6A5454&amp;amp;_z=z&quot;&gt;340B program&lt;/a&gt;&amp;nbsp;continues growing at a double-digit rate, as many hospitals and health systems are dependent on cashflow from it. Meanwhile, IQVIA modeled the impact if the IRA had been in effect when the 10 drugs selected for MFP first launched. For Enbrel alone, the IRA would have shaved nearly 14 years of economic life. As more drugs are selected for MFP, expect pricing pressures to grow amongst commercial payers due to the spillover of negotiated prices once they become public.&lt;/p&gt; &lt;h5&gt; How EBPs can adapt to growing margin pressures: &lt;/h5&gt; &lt;ul&gt; &lt;li&gt;As large pharma feels margin pressure, it increases their appetite for mergers and acquisitions. That&amp;rsquo;s especially true when they miss Wall Street&amp;rsquo;s expectations. &lt;/li&gt; &lt;li&gt;Get smart about the impact of the IRA and Medicare Price Negotiation. Since EBP exclusions can be negated if acquired by large pharma, royalty pricing strategies become more important. Across the board, EBPs need to be ready to transition launch price strategies to lifecycle price strategies. &lt;/li&gt; &lt;li&gt;Stay attuned to macrodynamic trends. Although some economic shifts may not directly influence decision making, they can have significant indirect influences on the life sciences environment.&lt;/li&gt; &lt;/ul&gt; &lt;p&gt; Will EBPs fall victim to the new market realities &amp;mdash; or create the strategies that lead to success in this brave new world? To learn more about how to thrive in the coming decade, watch the replay of the webinar, &lt;a rel=&quot;noopener noreferrer&quot; href=&quot;https://url.emailprotection.link/?bpS9ZQShCmdrkSqQA29YjmfLb85mLCOsAsOKsag554jHwdEN2_xjmJLM_Ha0qTeMZzDY80IUkC4UJhT9Ytal_pX-PwOV-zDfr9oooI9ESp1OaRCdz8yJyJABG5CUwGsI6ZKvnI8OubeFBuuSLOFlb_Paw-izJvgzaKFEQnwtgDeIgjs2rf3Z4Em7jKR7O-toRs-nYtVxAheiHt6P4LQFDPg~~&quot; target=&quot;_blank&quot;&gt;EBP Master Class: State of the Payer 2024 &amp;ndash; Dawn of a New Era&lt;/a&gt;.&lt;/p&gt;" /> <meta property="twitter:description" content="&lt;p&gt; The decade from 2014 to 2024 has brought significant changes to the life sciences industry. Pharma went into defensive mode as payers of all types introduced constraints on spend. Companies experienced declining launch returns alongside intense margin pressures. Given the rise in specialty treatments, more patients were navigating complex journeys &amp;mdash; driving significant investment into &lt;a href=&quot;~/link.aspx?_id=C1ED34E139F44508B407636D3D4E334F&amp;amp;_z=z&quot;&gt;patient support services&lt;/a&gt;.&lt;/p&gt; &lt;p&gt; As we look ahead to the next decade, we see a whole new set of dynamics at play, which includes impacts of the &lt;a href=&quot;~/link.aspx?_id=C28AFC3268244DCE8A6595E820893365&amp;amp;_z=z&quot;&gt;Inflation Reduction Act (IRA)&lt;/a&gt;, as well as blockbusters losing exclusivity, accelerating research and development activities, and growing evidence needs. Other forces of change include rising patient activism and consumerism, expanding metabolic treatments, evolving pricing strategies, and growing opportunities both technological (with advances in generative artificial intelligence) and geographical (as markets outside the U.S. become more important to success).&lt;/p&gt; &lt;p&gt; One thing is certain: What drove success in the decade behind won&amp;rsquo;t be effective in the one ahead.&lt;/p&gt; &lt;p&gt; In considering the State of the Payer 2024 for emerging biopharmas (EBPs), we have identified three key trends &amp;mdash; each with specific takeaways to help in shaping strategies for this brave new world.&lt;/p&gt; &lt;h4&gt; Trend #1: Plan for the &amp;lsquo;Modern Launch&amp;rsquo; &lt;/h4&gt; &lt;p&gt; IQVIA analysis found that from 2014 to 2023, the median annual cost of treatment at launch went up by 84% for non-oncology orphan treatments and 191% for oncology treatments. This finding reflects companies&amp;rsquo; changing pipelines and focus on narrower patient populations. It also illuminates why payers keep increasing controls to mitigate spend. &lt;/p&gt; &lt;p&gt; As we studied &lt;a href=&quot;~/link.aspx?_id=37E3FE0288CC422687F20A52D6CA99FE&amp;amp;_z=z&quot;&gt;brand launches&lt;/a&gt;, 2020 emerged as a turning point in terms of launch strategies and performance. Across nearly all therapeutic categories, post-pandemic launches consistently underperform pre-pandemic trends. While payers used to control costs more heavily at launch, they&amp;rsquo;re now limiting access gains into subsequent years, too. As a result, average launch efficiency decreased 12% from 2018 to 2023. In some cases, manufacturers are stepping in as primary payer to get a patient on therapy &amp;mdash; fully subsidizing as much as 90% of demand! In this new world, Modern Launch windows are 18 to 36 months, suggesting that brands need more time to gauge launch performance.&lt;/p&gt; &lt;h5&gt; How EBPs can adapt to the Modern Launch: &lt;/h5&gt; &lt;ul&gt; &lt;li&gt;More than 75% of launches are missing their first-year forecast &amp;mdash; suggesting an urgent need to reassess launch forecasting. &lt;/li&gt; &lt;li&gt;A longer launch means that investment needs to accelerate or to be maintained at higher levels for a longer period. EBPs need to be prepared to launch twice as fast or take twice as long. &lt;/li&gt; &lt;li&gt;Markets and prescribers are getting sensitized to large and generous manufacturer support programs. EBPs should plan to provide high levels of patient support while in launch mode.&lt;/li&gt; &lt;/ul&gt; &lt;h4&gt; Trend #2: Obesity is shaking the market &lt;/h4&gt; &lt;p&gt; Obesity is poised to become a top-five global market with a profound effect on spending across multiple areas. The first cohort of treatments has transformed the fortunes of Lilly and Novo Nordisk &amp;mdash; propelling them to #1 and #2, respectively, in market capitalization. Longer-term impacts are still taking shape. For now, payer control is high in &lt;a href=&quot;~/link.aspx?_id=6353A768D75C4BADADE4261DF06B0079&amp;amp;_z=z&quot;&gt;managing GLP-1 treatments&lt;/a&gt;. At the same time, more competition will be entering the market &amp;mdash; creating downward price pressures and a proliferation of options for consumers.&lt;/p&gt; &lt;p&gt; For patients with obesity, there is a direct correlation between age, body mass index (BMI), and the number of comorbidities. That means there will be profound effect on many classes of drugs as treatment expands to more patients. In the short term, more patients seeking weight-loss treatment could increase diagnosis of other diseases, driving demand for other therapeutic areas. But over the next decade, patients being treated for obesity could lead to lower demand for drugs in therapeutic areas like diabetes, cardiovascular disease, immunology, oncology, and kidney disease.&lt;/p&gt; &lt;h5&gt; What all brands can learn from the GLP-1 launches: &lt;/h5&gt; &lt;ul&gt; &lt;li&gt;Consumerism drove significant demand. Tapping into consumer motivation can drive early patient volumes &amp;mdash; making patient awareness and advocacy keys to success. &lt;/li&gt; &lt;li&gt;Obesity treatments have direct and indirect impacts on many therapeutic areas. In the short term, overlapping comorbidities can create tailwinds. But over the long term, obesity treatments will create headwinds. &lt;/li&gt; &lt;li&gt;Healthcare providers who embraced GLP-1s are demonstrative of early adopters of a modern launch. EBPs should understand who is adopting and where to gain insights into prescriber behavior and promotional influence.&lt;/li&gt; &lt;/ul&gt; &lt;h4&gt; Trend #3: Margin challenges are expanding &lt;/h4&gt; &lt;p&gt; A decade ago, retail branded drug gross margins were around 70%; as of 2022, the average was nearly halved to just 37%. There are many contributing factors beyond payer control and rebate pressure. Industry wide, copay offset costs have doubled since 2018, with pharma spending $23.1 billion on copay cards and debit costs in 2023. The &lt;a href=&quot;~/link.aspx?_id=A0D1FA83524E44478BDAF4E89E6A5454&amp;amp;_z=z&quot;&gt;340B program&lt;/a&gt;&amp;nbsp;continues growing at a double-digit rate, as many hospitals and health systems are dependent on cashflow from it. Meanwhile, IQVIA modeled the impact if the IRA had been in effect when the 10 drugs selected for MFP first launched. For Enbrel alone, the IRA would have shaved nearly 14 years of economic life. As more drugs are selected for MFP, expect pricing pressures to grow amongst commercial payers due to the spillover of negotiated prices once they become public.&lt;/p&gt; &lt;h5&gt; How EBPs can adapt to growing margin pressures: &lt;/h5&gt; &lt;ul&gt; &lt;li&gt;As large pharma feels margin pressure, it increases their appetite for mergers and acquisitions. That&amp;rsquo;s especially true when they miss Wall Street&amp;rsquo;s expectations. &lt;/li&gt; &lt;li&gt;Get smart about the impact of the IRA and Medicare Price Negotiation. Since EBP exclusions can be negated if acquired by large pharma, royalty pricing strategies become more important. Across the board, EBPs need to be ready to transition launch price strategies to lifecycle price strategies. &lt;/li&gt; &lt;li&gt;Stay attuned to macrodynamic trends. Although some economic shifts may not directly influence decision making, they can have significant indirect influences on the life sciences environment.&lt;/li&gt; &lt;/ul&gt; &lt;p&gt; Will EBPs fall victim to the new market realities &amp;mdash; or create the strategies that lead to success in this brave new world? To learn more about how to thrive in the coming decade, watch the replay of the webinar, &lt;a rel=&quot;noopener noreferrer&quot; href=&quot;https://url.emailprotection.link/?bpS9ZQShCmdrkSqQA29YjmfLb85mLCOsAsOKsag554jHwdEN2_xjmJLM_Ha0qTeMZzDY80IUkC4UJhT9Ytal_pX-PwOV-zDfr9oooI9ESp1OaRCdz8yJyJABG5CUwGsI6ZKvnI8OubeFBuuSLOFlb_Paw-izJvgzaKFEQnwtgDeIgjs2rf3Z4Em7jKR7O-toRs-nYtVxAheiHt6P4LQFDPg~~&quot; target=&quot;_blank&quot;&gt;EBP Master Class: State of the Payer 2024 &amp;ndash; Dawn of a New Era&lt;/a&gt;.&lt;/p&gt;" /> <meta property="og:url" content="https://www.iqvia.com/locations/united-states/blogs/2024/07/emerging-biopharma-master-class-state-of-the-payer-2024" /> <meta property="twitter:site" content="https://www.iqvia.com/locations/united-states/blogs/2024/07/emerging-biopharma-master-class-state-of-the-payer-2024" /> <link href="/Content/Shotgun/css/coveo?v=5f2TXK9t8FlC_0aw4cAoVYcmCiwv63sB9xo1gz4KnGg1" rel="stylesheet"/> <link 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</div> </div> </li> </ul> </div> <div class="main"> <div class="container container-ruler"> <div class="logo"> <a class="d-flex" href="https://www.iqvia.com/locations/united-states" style="width: 168px;"> <img src="/-/media/iqvia/iqvia-logo-white.svg?mw=300&amp;hash=F1AF36720BFE3D652588EF9344ED481F" alt="IQVIA Healthcare Information Technology and Pharma Clinical Research Company" width="160"> </a> </div> <div class="mobile-toggle mobile-toggle-navigation-bar"><span></span><span></span><span></span></div> <nav class="d-flex justify-between" aria-label="Primary"> <ol class="primary-nav w-100"> <li> <a class="color-white" href="#">Who We Help</a> <div class="primary-nav-wrapper"> <div class="content solution-selector"> <div class="shadow"></div> <div class="d-flex flex-column "> <div class="d-flex flex-column"> <div class="d-flex tab"> <div class="w-20 d-flex flex-column list"> <h5 class="sub-title ">WHO WE HELP</h5> <ol class="solution-tabs open-first"> <li class="tab-title cursor-pointer d-flex align-center"> <a class="list-item-style text-decoration-none after-none" href="https://www.iqvia.com/locations/united-states/solutions/life-sciences">Pharmaceutical Manufacturers</a> <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="7.029" height="12" viewBox="0 0 7.029 12"> <g id="Chevron" transform="translate(-135.26 -19.823)"> <rect id="Rectangle_125" data-name="Rectangle 125" width="8.521" height="1.42" rx="0.71" transform="translate(136.264 19.823) rotate(45)" fill="#959ca0"></rect> <rect id="Rectangle_126" data-name="Rectangle 126" width="8.521" height="1.42" rx="0.71" transform="translate(135.26 30.819) rotate(-45)" fill="#959ca0"></rect> </g> </svg> </div> </li> <li class="tab-title cursor-pointer d-flex align-center"> <a class="list-item-style text-decoration-none after-none" href="https://www.iqvia.com/solutions/industry-segments/emerging-biopharma">Emerging Biopharma</a> <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" 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rotate(45)" fill="#959ca0"></rect> <rect id="Rectangle_126" data-name="Rectangle 126" width="8.521" height="1.42" rx="0.71" transform="translate(135.26 30.819) rotate(-45)" fill="#959ca0"></rect> </g> </svg> </div> </li> <li class="tab-title cursor-pointer d-flex align-center"> <a class="list-item-style text-decoration-none after-none" href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/insurer-and-risk-solutions">Insurers and Risk</a> <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="7.029" height="12" viewBox="0 0 7.029 12"> <g id="Chevron" transform="translate(-135.26 -19.823)"> <rect id="Rectangle_125" data-name="Rectangle 125" width="8.521" height="1.42" rx="0.71" transform="translate(136.264 19.823) rotate(45)" fill="#959ca0"></rect> <rect id="Rectangle_126" data-name="Rectangle 126" width="8.521" height="1.42" rx="0.71" transform="translate(135.26 30.819) rotate(-45)" fill="#959ca0"></rect> </g> </svg> </div> </li> <li class="tab-title cursor-pointer d-flex align-center"> <a class="list-item-style text-decoration-none after-none" href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/medical-specialty-societies">Medical Specialty and Patient Advocacy</a> <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="7.029" height="12" viewBox="0 0 7.029 12"> <g id="Chevron" transform="translate(-135.26 -19.823)"> <rect id="Rectangle_125" data-name="Rectangle 125" width="8.521" height="1.42" rx="0.71" transform="translate(136.264 19.823) rotate(45)" fill="#959ca0"></rect> <rect id="Rectangle_126" data-name="Rectangle 126" width="8.521" height="1.42" rx="0.71" transform="translate(135.26 30.819) rotate(-45)" fill="#959ca0"></rect> </g> </svg> </div> </li> </ol> </div> <div class="w-80 tab-content solutions"> <div class="item h-100 default-content mt-0"> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 "> <div class="w-33"> <h3>Pharmaceutical Manufacturers</h3> <p>Harness unparalleled healthcare data, advanced analytics, and cutting-edge technologies with our expertise to accelerate the development and commercialization of innovative medicines, enhancing patient lives.</p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/life-sciences" style="max-width: 303px;">Discover More</a> </div> <div class="w-33"> <h6 class="pt-0 border-left pb-11 mt-0">Pharmaceutical Manufacturers</h6> <ol class="border-left"> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/commercial-solutions">Commercial Solutions</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/contract-sales-and-medical-solutions">Contract Sales and Medical Solutions</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/digital-enablement-center-of-excellence">Digital Enablement Center of Excellence</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/information-solutions">Information Solutions</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/medical-affairs">Medical Affairs</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/real-world-evidence">Real World Evidence</a></li> </ol> </div> </div> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 no-links"> <div class="w-33"> <img src="/-/media/iqvia/images/modules/brandworld/920_group-of-people-looking-at-data-during-business-meeting.jpg?h=683&amp;w=1024&amp;hash=9F1D12445AA35397B08A93A0D4506A73"> </div> <div class="w-33"> <h3>Emerging Biopharma (Global page)</h3> <p>Boost your innovation with IQVIA&#39;s expert team. Our comprehensive solutions integrate top-tier insights, technology, and expertise to maximize your asset&#39;s success in a competitive landscape.</p> <a class="btn" href="https://www.iqvia.com/solutions/industry-segments/emerging-biopharma" style="max-width: 303px;">Discover Innovations</a> </div> </div> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 "> <div class="w-33"> <h3>MedTech</h3> <p>Navigating MedTech&#39;s unique landscape: U.S. decision-making now rests with GPOs, IDNs, and payers, who demand solid value proof through rigorous outcomes analyses and pricing scrutiny.</p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment" style="max-width: 303px;">Explore MedTech</a> </div> <div class="w-33"> <h6 class="pt-0 border-left pb-11 mt-0">MedTech</h6> <ol class="border-left"> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/commercial-field-solutions">Commercial Field Solutions</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/hospital-procedures-and-diagnosis">Hospital Procedures and Diagnosis</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/medical-device-supply-audit">Medical Device Supply Audit</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/medtech-business-insights-and-trends-podcast-series">MedTech Business Insights and Trends Podcast Series</a></li> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/medtech-market-activator-platform">MedTech Market Activator Platform</a></li> </ol> </div> </div> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 no-links"> <div class="w-33"> <img src="/-/media/iqvia/images/modules/brandworld/441_custom-photo_two-professionals-focused-on-laptop-information---copy_600.jpg?h=683&amp;w=1024&amp;hash=6C0045E8A4B73FC243BD062B0CE70586"> </div> <div class="w-33"> <h3>Financial Institutions</h3> <p>Invest in healthcare with confidence. Stay ahead of pharma and medical device trends using real-time, high-quality data. Access market insights, historical sales, prescription trends, and emerging product information for informed, risk-reduced decisions.</p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/financial-services" style="max-width: 303px;">Access Insights</a> </div> </div> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 "> <div class="w-33"> <h3>Government and Public Health</h3> <p>Unlock deeper health insights with unmatched data and innovative technology to enhance decision-making for your essential government programs.</p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/government-segment" style="max-width: 303px;">Unlock Innovations</a> </div> <div class="w-33"> <h6 class="pt-0 border-left pb-11 mt-0">Government and Public Health</h6> <ol class="border-left"> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/government-segment/government-solutions">CIO-CS</a></li> </ol> </div> </div> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 no-links"> <div class="w-33"> <img src="/-/media/iqvia/images/modules/brandworld/490_custom-photo_professional-carefully-reviewing-data-information.jpg?h=683&amp;w=1024&amp;hash=3C77D651DBA851B8FED8D62CDCB4CFC6"> </div> <div class="w-33"> <h3>Health Plans</h3> <p>Accelerate digital innovation with our data-driven expertise in data science and healthcare, optimizing business processes for smarter decisions.</p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/payers-segment" style="max-width: 303px;">Navigate Health Plans</a> </div> </div> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 "> <div class="w-33"> <h3>Hospital and Health Systems</h3> <p>Leverage digital innovation to cut costs, boost efficiency, and elevate patient engagement, all while enhancing quality and health outcomes.</p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/providers-segment" style="max-width: 303px;">Streamline Decisions</a> </div> <div class="w-33"> <h6 class="pt-0 border-left pb-11 mt-0">Hospital and Health Systems</h6> <ol class="border-left"> <li class="hover-color-blue"><a href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/providers-segment/hospital-data-exchange-program">Hospital Data Exchange Program</a></li> </ol> </div> </div> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 no-links"> <div class="w-33"> <img src="/-/media/iqvia/images/modules/brandworld/2137_it-professionals-programming-in-coding-language.png?h=576&amp;w=1024&amp;hash=E95DC0942533073BFAC07BFBCA46877D"> </div> <div class="w-33"> <h3>Insurers and Risk</h3> <p>Enhance your ability to evaluate and forecast population risk swiftly and accurately by integrating unmatched data, expertise, and technology. </p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/insurer-and-risk-solutions" style="max-width: 303px;">Uncover More</a> </div> </div> </div> <div class="item bg h-100 align-center"> <div class="d-flex align-center w-100 no-links"> <div class="w-33"> <img src="/-/media/iqvia/images/modules/brandworld/2436_doctor-and-nurse-with-digital-tablet-talking.png?h=619&amp;w=1024&amp;hash=98E8877207191BDCEB7979FB8FB2BDF8"> </div> <div class="w-33"> <h3>Medical Specialty and Patient Advocacy</h3> <p>Transform into a data-driven organization that enhances your specialty and showcases value to your members through digital transformation. </p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/healthcare-solutions/medical-specialty-societies" style="max-width: 303px;">Explore Now</a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </li> <li> <a class="color-white" href="#">Insights</a> <div class="primary-nav-wrapper"> <div class="content insights"> <div class="shadow"></div> <div class="d-flex remove-last"> <div class="w-50"> <div class="d-flex pt-75"> <div class="w-50"> <h5>U.S. PROGRESS POINT</h5> <p>A curation of IQVIA&#39;s best thinking on topics and trends driving change, disruption, and progress in the United States healthcare market.</p> <a class="hover-color-blue-with-anim" href="https://www.iqvia.com/locations/united-states/us-progress-point"> LEARN MORE <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="7.029" height="12" viewBox="0 0 7.029 12"> <g id="Chevron" transform="translate(-135.26 -19.823)"> <rect id="Rectangle_125" data-name="Rectangle 125" width="8.521" height="1.42" rx="0.71" transform="translate(136.264 19.823) rotate(45)" fill="#959ca0"></rect> <rect id="Rectangle_126" data-name="Rectangle 126" width="8.521" height="1.42" 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<div class="card-wrapper"> <div class="card"> <img src="/-/media/iqvia/images/modules/brandworld/2447_woman-watching-business-training-on-laptop-and-learning-from-home.jpg?h=800&amp;w=1200&amp;hash=7138103CD56C8FC464E41DA86DD886F0"> <h5 class="title">PODCASTS</h5> <p class="description">Discover the future through our enlightening podcasts available in the United States.</p> <a class="hover-color-blue-with-anim" href="https://www.iqvia.com/locations/united-states/insights#f:type=[Podcast]"> EXPLORE PODCASTS <div class="icon"> <svg xmlns="http://www.w3.org/2000/svg" width="7.029" height="12" viewBox="0 0 7.029 12"> <g id="Chevron" transform="translate(-135.26 -19.823)"> <rect id="Rectangle_125" data-name="Rectangle 125" width="8.521" height="1.42" rx="0.71" transform="translate(136.264 19.823) rotate(45)" fill="#959ca0"></rect> <rect id="Rectangle_126" data-name="Rectangle 126" width="8.521" height="1.42" rx="0.71" transform="translate(135.26 30.819) rotate(-45)" fill="#959ca0"></rect> 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development and commercialization of innovative medicines, enhancing patient lives.</p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/life-sciences">Discover More</a> <div class="hr"></div> <h6>Pharmaceutical Manufacturers</h6> <ul> <li><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/commercial-solutions">Commercial Solutions</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/contract-sales-and-medical-solutions">Contract Sales and Medical Solutions</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/digital-enablement-center-of-excellence">Digital Enablement Center of Excellence</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/information-solutions">Information Solutions</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/medical-affairs">Medical Affairs</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/life-sciences/real-world-evidence">Real World Evidence</a></li> </ul> </div> <div class="tab-item"> <img src="/-/media/iqvia/images/modules/brandworld/920_group-of-people-looking-at-data-during-business-meeting.jpg?h=683&amp;w=1024&amp;hash=9F1D12445AA35397B08A93A0D4506A73"> <h5>Emerging Biopharma (Global page)</h5> <p>Boost your innovation with IQVIA&#39;s expert team. Our comprehensive solutions integrate top-tier insights, technology, and expertise to maximize your asset&#39;s success in a competitive landscape.</p> <a class="btn w-auto mt-30" href="https://www.iqvia.com/solutions/industry-segments/emerging-biopharma">Discover Innovations</a> </div> <div class="tab-item"> <h5>MedTech</h5> <p>Navigating MedTech&#39;s unique landscape: U.S. decision-making now rests with GPOs, IDNs, and payers, who demand solid value proof through rigorous outcomes analyses and pricing scrutiny.</p> <a class="btn" href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment">Explore MedTech</a> <div class="hr"></div> <h6>MedTech</h6> <ul> <li><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/commercial-field-solutions">Commercial Field Solutions</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/hospital-procedures-and-diagnosis">Hospital Procedures and Diagnosis</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/medical-device-supply-audit">Medical Device Supply Audit</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/medtech-business-insights-and-trends-podcast-series">MedTech Business Insights and Trends Podcast Series</a></li> <li><a href="https://www.iqvia.com/locations/united-states/solutions/medical-device-and-diagnostic-segment/medtech-market-activator-platform">MedTech Market Activator Platform</a></li> </ul> </div> <div class="tab-item"> <img src="/-/media/iqvia/images/modules/brandworld/441_custom-photo_two-professionals-focused-on-laptop-information---copy_600.jpg?h=683&amp;w=1024&amp;hash=6C0045E8A4B73FC243BD062B0CE70586"> <h5>Financial Institutions</h5> <p>Invest in healthcare with confidence. 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Pharma went into defensive mode as payers of all types introduced constraints on spend. Companies experienced declining launch returns alongside intense margin pressures. Given the rise in specialty treatments, more patients were navigating complex journeys &mdash; driving significant investment into <a href="https://www.iqvia.com/locations/united-states/blogs/2024/05/patient-support-programs-for-ebps-three-imperatives-to-measure-what-matters">patient support services</a>.</p> <p> As we look ahead to the next decade, we see a whole new set of dynamics at play, which includes impacts of the <a href="https://www.iqvia.com/locations/united-states/blogs/2023/05/making-the-right-moves-part-2">Inflation Reduction Act (IRA)</a>, as well as blockbusters losing exclusivity, accelerating research and development activities, and growing evidence needs. Other forces of change include rising patient activism and consumerism, expanding metabolic treatments, evolving pricing strategies, and growing opportunities both technological (with advances in generative artificial intelligence) and geographical (as markets outside the U.S. become more important to success).</p> <p> One thing is certain: What drove success in the decade behind won&rsquo;t be effective in the one ahead.</p> <p> In considering the State of the Payer 2024 for emerging biopharmas (EBPs), we have identified three key trends &mdash; each with specific takeaways to help in shaping strategies for this brave new world.</p> <h4> Trend #1: Plan for the &lsquo;Modern Launch&rsquo; </h4> <p> IQVIA analysis found that from 2014 to 2023, the median annual cost of treatment at launch went up by 84% for non-oncology orphan treatments and 191% for oncology treatments. This finding reflects companies&rsquo; changing pipelines and focus on narrower patient populations. It also illuminates why payers keep increasing controls to mitigate spend. </p> <p> As we studied <a href="https://www.iqvia.com/library/case-studies/how-emerging-biopharma-companies-can-successfully-launch-their-asset">brand launches</a>, 2020 emerged as a turning point in terms of launch strategies and performance. Across nearly all therapeutic categories, post-pandemic launches consistently underperform pre-pandemic trends. While payers used to control costs more heavily at launch, they&rsquo;re now limiting access gains into subsequent years, too. As a result, average launch efficiency decreased 12% from 2018 to 2023. In some cases, manufacturers are stepping in as primary payer to get a patient on therapy &mdash; fully subsidizing as much as 90% of demand! In this new world, Modern Launch windows are 18 to 36 months, suggesting that brands need more time to gauge launch performance.</p> <h5> How EBPs can adapt to the Modern Launch: </h5> <ul> <li>More than 75% of launches are missing their first-year forecast &mdash; suggesting an urgent need to reassess launch forecasting. </li> <li>A longer launch means that investment needs to accelerate or to be maintained at higher levels for a longer period. EBPs need to be prepared to launch twice as fast or take twice as long. </li> <li>Markets and prescribers are getting sensitized to large and generous manufacturer support programs. EBPs should plan to provide high levels of patient support while in launch mode.</li> </ul> <h4> Trend #2: Obesity is shaking the market </h4> <p> Obesity is poised to become a top-five global market with a profound effect on spending across multiple areas. The first cohort of treatments has transformed the fortunes of Lilly and Novo Nordisk &mdash; propelling them to #1 and #2, respectively, in market capitalization. Longer-term impacts are still taking shape. For now, payer control is high in <a href="https://www.iqvia.com/locations/united-states/blogs/2023/08/transitional-assistance-programs-in-the-glp1-market">managing GLP-1 treatments</a>. At the same time, more competition will be entering the market &mdash; creating downward price pressures and a proliferation of options for consumers.</p> <p> For patients with obesity, there is a direct correlation between age, body mass index (BMI), and the number of comorbidities. That means there will be profound effect on many classes of drugs as treatment expands to more patients. In the short term, more patients seeking weight-loss treatment could increase diagnosis of other diseases, driving demand for other therapeutic areas. But over the next decade, patients being treated for obesity could lead to lower demand for drugs in therapeutic areas like diabetes, cardiovascular disease, immunology, oncology, and kidney disease.</p> <h5> What all brands can learn from the GLP-1 launches: </h5> <ul> <li>Consumerism drove significant demand. Tapping into consumer motivation can drive early patient volumes &mdash; making patient awareness and advocacy keys to success. </li> <li>Obesity treatments have direct and indirect impacts on many therapeutic areas. In the short term, overlapping comorbidities can create tailwinds. But over the long term, obesity treatments will create headwinds. </li> <li>Healthcare providers who embraced GLP-1s are demonstrative of early adopters of a modern launch. EBPs should understand who is adopting and where to gain insights into prescriber behavior and promotional influence.</li> </ul> <h4> Trend #3: Margin challenges are expanding </h4> <p> A decade ago, retail branded drug gross margins were around 70%; as of 2022, the average was nearly halved to just 37%. There are many contributing factors beyond payer control and rebate pressure. Industry wide, copay offset costs have doubled since 2018, with pharma spending $23.1 billion on copay cards and debit costs in 2023. The <a href="/sitecore/service/notfound.aspx?item=web%3a%7bA0D1FA83-524E-4447-8BDA-F4E89E6A5454%7d%40en">340B program</a>&nbsp;continues growing at a double-digit rate, as many hospitals and health systems are dependent on cashflow from it. Meanwhile, IQVIA modeled the impact if the IRA had been in effect when the 10 drugs selected for MFP first launched. For Enbrel alone, the IRA would have shaved nearly 14 years of economic life. As more drugs are selected for MFP, expect pricing pressures to grow amongst commercial payers due to the spillover of negotiated prices once they become public.</p> <h5> How EBPs can adapt to growing margin pressures: </h5> <ul> <li>As large pharma feels margin pressure, it increases their appetite for mergers and acquisitions. That&rsquo;s especially true when they miss Wall Street&rsquo;s expectations. </li> <li>Get smart about the impact of the IRA and Medicare Price Negotiation. Since EBP exclusions can be negated if acquired by large pharma, royalty pricing strategies become more important. Across the board, EBPs need to be ready to transition launch price strategies to lifecycle price strategies. </li> <li>Stay attuned to macrodynamic trends. Although some economic shifts may not directly influence decision making, they can have significant indirect influences on the life sciences environment.</li> </ul> <p> Will EBPs fall victim to the new market realities &mdash; or create the strategies that lead to success in this brave new world? To learn more about how to thrive in the coming decade, watch the replay of the webinar, <a rel="noopener noreferrer" href="https://url.emailprotection.link/?bpS9ZQShCmdrkSqQA29YjmfLb85mLCOsAsOKsag554jHwdEN2_xjmJLM_Ha0qTeMZzDY80IUkC4UJhT9Ytal_pX-PwOV-zDfr9oooI9ESp1OaRCdz8yJyJABG5CUwGsI6ZKvnI8OubeFBuuSLOFlb_Paw-izJvgzaKFEQnwtgDeIgjs2rf3Z4Em7jKR7O-toRs-nYtVxAheiHt6P4LQFDPg~~" target="_blank">EBP Master Class: State of the Payer 2024 &ndash; Dawn of a New Era</a>.</p> </div> </div> </section> <section id="RelatedSolutions"></section> <section class="multi-card__carousel-redesign init-js-related"> <div class="multi-card__outer"> <div class="multi-card__wrapper"> <div class="multi-card__inner"> <h2 class="eyebrow"> You may also be interested in </h2> <div class="swiper swiper-container"> <div class="swiper-wrapper"> <div class="swiper-slide"> <div class="card-item card-link"> <a 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url(&#39;/-/media/iqvia/images/modules/brandworld/988_cancer-patient-meeting-with-female-physician.jpg?mw=600&amp;hash=3872E0FB6B3D3392E5F8E2EF51633451&#39;)"></div> </a> <div class="card-item_wrapper"> <div class="badge"> White Paper</div> <div class="card-title"> <a href="https://www.iqvia.com/locations/asia-pacific/library/white-papers/accelerating-patient-access-to-precision-oncology-in-asia-pacific-summary" target="_self">Accelerating patient access to precision oncology in Asia Pacific (Summary)</a> </div> </div> </div> </div> </div> <div class="control-panel"> <div class="fake-block"></div> <div class="swiper-control"> <div class="button-prev"><i class="fa-solid fa-chevron-left"></i><span>Prev</span></div> <div class="swiper-pagination"></div> <div class="button-next"><span>Next</span><i class="fa fa-chevron-right"></i></div> </div> <div class="fake-block"></div> </div> </div> </div> </div> </div> </section> <!-- BEGIN NOINDEX --> <section 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