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About: Vesicular monoamine transporter 2
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SLC18A2 is an integral membrane protein that transports monoamines—particularly neurotransmitters such as dopamine, norepinephrine, serotonin, and histamine—from cellular cytosol into synaptic vesicles. In nigrostriatal pathway and mesolimbic pathway dopamine-releasing neurons, SLC18A2 function is also necessary for the vesicular release of the neurotransmitter GABA." /> <meta property="og:site_name" content="DBpedia" /> <!-- /OpenGraph--> </head> <body about="http://dbpedia.org/resource/Vesicular_monoamine_transporter_2"> <!-- navbar --> <nav class="navbar navbar-expand-md navbar-light bg-light fixed-top align-items-center"> <div class="container-xl"> <a class="navbar-brand" href="http://wiki.dbpedia.org/about" title="About DBpedia" style="color: #2c5078"> <img class="img-fluid" src="/statics/images/dbpedia_logo_land_120.png" alt="About DBpedia" /> </a> <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#dbp-navbar" aria-controls="dbp-navbar" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="collapse navbar-collapse" id="dbp-navbar"> <ul class="navbar-nav me-auto mb-2 mb-lg-0"> <li 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class="text-nowrap">An Entity of Type: <a href="http://dbpedia.org/ontology/Protein">protein</a>, </span> <span class="text-nowrap">from Named Graph: <a href="http://dbpedia.org">http://dbpedia.org</a>, </span> <span class="text-nowrap">within Data Space: <a href="http://dbpedia.org">dbpedia.org</a></span> </div> </div> </div> <div class="row pt-2"> <div class="col-xs-9 col-sm-10"> <p class="lead">The solute carrier family 18 member 2 (SLC18A2) also known as vesicular monoamine transporter 2 (VMAT2) is a protein that in humans is encoded by the SLC18A2 gene. SLC18A2 is an integral membrane protein that transports monoamines—particularly neurotransmitters such as dopamine, norepinephrine, serotonin, and histamine—from cellular cytosol into synaptic vesicles. In nigrostriatal pathway and mesolimbic pathway dopamine-releasing neurons, SLC18A2 function is also necessary for the vesicular release of the neurotransmitter GABA.</p> </div> </div> </div> </section> <!-- page-header --> <!-- property-table --> <section> <div class="container-xl"> <div class="row"> <div class="table-responsive"> <table class="table table-hover table-sm table-light"> <thead> <tr> <th class="col-xs-3 ">Property</th> <th class="col-xs-9 px-3">Value</th> </tr> </thead> <tbody> <tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/abstract"><small>dbo:</small>abstract</a> </td><td class="col-10 text-break"><ul> <li style="display:none;"><span class="literal"><span property="dbo:abstract" lang="ar" >ناقل أحادي الأمين الحويصلي 2 (بالإنجليزية: vesicular monoamine transporter 2) واختصارا (فِمات 2 : VMAT2) ويعرف كذلك باسم عائلة حامل المذاب 18 العنصر 2 (SLC18A2) هو بروتين يُشفَّر لدى البشر بواسطة الجين SLC18A2. VMAT2 هو بروتين غشائي مدمج ينقل أحاديات الأمين وبشكل خاص النواقل العصبية مثل الدوبامين النورإبينفرين، السيروتونين والهيستامين من العصارة الخلوية إلى الحويصلات المشبكية. في المسار السوداوي المخططي والمسار الوسطي الطرفي للعصبونات المحررة للدوبامين، وظيفة VMAT2 ضرورية أيضا بالنسبة للتحرير الحويصلي للناقل العصبي غابا.</span><small> (ar)</small></span></li> <li style="display:none;"><span class="literal"><span property="dbo:abstract" lang="de" >Der vesikuläre Monoamintransporter (VMAT, VMAT2) ist ein Protein in der Membran zytoplasmischer Vesikel innerhalb von Nervenzellen. Es erleichtert den Zufluss der Neurotransmitter Dopamin, Serotonin, Histamin und Noradrenalin in die Vesikel, bevor diese mittels Exozytose in den synaptischen Spalt entleert werden. Es handelt sich bei VMAT2 also um einen Membrantransporter, und zwar aus der Major-Facilitator-Superfamilie. VMAT2 ist nur in Wirbeltieren zu finden. Beim Menschen ist VMAT2 außer im ZNS besonders in Inselzellen und im Uterus lokalisiert. Im Pankreas spielt VMAT2 eine regulatorische Rolle bei der Insulinantwort auf Glucose. Die Transportgleichung lautet: Monoaminaußen + H+innen ⇒ Monoamininnen + H+außen Es handelt sich also um einen Antiport. Es existieren Geschlechtsunterschiede in der neuronalen VMAT2-Aktivität, die die unterschiedliche Antwort auf Methamphetamin erklären, wie an einer Studie mit Mäusen festgestellt wurde. Die Verpackung von Dopamin in dopaminergen Neuronen durch VMAT2 ist unentbehrlich, um möglichen Schäden durch oxidiertes Dopamin bei oxidativem Stress oder nach Methamphetamin-Zufuhr vorzubeugen. Mäuse mit nur 5–10 % VMAT2 zeigten eine schnelle Schädigung solcher Neuronen. VMAT2 ist durch die enge Assoziation mit der Insulinproduktion in Inselzellen ein geeignetes Target für die Diabetes-Diagnose. Mehrere Stoffe sind als Hemmer des VMAT2 bekannt, unter anderem Reserpin und Tetrabenazin. In seinem Buch „The God Gene“ (dt. „Das Gottes-Gen. Warum uns der Glaube im Blut liegt“) machte der Molekularbiologe Dean Hamer VMAT2 für religiöse Empfindungen des Menschen verantwortlich. Die Stichhaltigkeit seiner Theorie ist nach wie vor umstritten.</span><small> (de)</small></span></li> <li style="display:none;"><span class="literal"><span property="dbo:abstract" lang="fr" >VMAT2 (Vesicular monoamine transporter 2, Transporteur vésiculaire des monoamines 2) est une protéine qui, chez les humains, est encodée par le gène situé sur le chromosome 10. C'est une protéine membranaire intégrale qui transporte des monoamines -et plus particulièrement des neurotransmetteurs comme la dopamine, la noradrénaline, la sérotonine et l'histamine- depuis le cytosol cellulaire jusqu'aux vésicules synaptiques.</span><small> (fr)</small></span></li> <li><span class="literal"><span property="dbo:abstract" lang="en" >The solute carrier family 18 member 2 (SLC18A2) also known as vesicular monoamine transporter 2 (VMAT2) is a protein that in humans is encoded by the SLC18A2 gene. SLC18A2 is an integral membrane protein that transports monoamines—particularly neurotransmitters such as dopamine, norepinephrine, serotonin, and histamine—from cellular cytosol into synaptic vesicles. In nigrostriatal pathway and mesolimbic pathway dopamine-releasing neurons, SLC18A2 function is also necessary for the vesicular release of the neurotransmitter GABA.</span><small> (en)</small></span></li> <li style="display:none;"><span class="literal"><span property="dbo:abstract" lang="pt" >O transportador vesicular de monoamina 2 (VMAT2) é uma proteína que em humanos é codificada pelo gene SLC18A2. VMAT2 é uma proteína integral de membrama que transporta monoaminas — particularmente neurotransmissores como dopamina, norepinefrina, serotonina e histamina — da matriz citoplasmática celular para as vesículas sinápticas. Na via nigroestriatal e na via mesolímbica dos neurônios liberadores de dopamina, a função do VMAT2 também é necessária para a liberação vesicular do neurotransmissor GABA.</span><small> (pt)</small></span></li> <li style="display:none;"><span class="literal"><span property="dbo:abstract" lang="uk" >SLC18A2 (англ. Solute carrier family 18 member A2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 10-ї хромосоми. Довжина поліпептидного ланцюга білка становить 514 амінокислот, а молекулярна маса — 55 713. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у таких біологічних процесах, як транспорт, альтернативний сплайсинг. Локалізований у мембрані, цитоплазматичних везикулах.</span><small> (uk)</small></span></li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/wikiPageID"><small>dbo:</small>wikiPageID</a> </td><td class="col-10 text-break"><ul> <li><span class="literal"><span property="dbo:wikiPageID" datatype="xsd:integer" >4803621</span><small> (xsd:integer)</small></span></li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/wikiPageLength"><small>dbo:</small>wikiPageLength</a> </td><td class="col-10 text-break"><ul> <li><span class="literal"><span property="dbo:wikiPageLength" datatype="xsd:nonNegativeInteger" >17607</span><small> (xsd:nonNegativeInteger)</small></span></li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/wikiPageRevisionID"><small>dbo:</small>wikiPageRevisionID</a> </td><td class="col-10 text-break"><ul> <li><span 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VMAT2 هو بروتين غشائي مدمج ينقل أحاديات الأمين وبشكل خاص النواقل العصبية مثل الدوبامين النورإبينفرين، السيروتونين والهيستامين من العصارة الخلوية إلى الحويصلات المشبكية. في المسار السوداوي المخططي والمسار الوسطي الطرفي للعصبونات المحررة للدوبامين، وظيفة VMAT2 ضرورية أيضا بالنسبة للتحرير الحويصلي للناقل العصبي غابا.</span><small> (ar)</small></span></li> <li style="display:none;"><span class="literal"><span property="rdfs:comment" lang="fr" >VMAT2 (Vesicular monoamine transporter 2, Transporteur vésiculaire des monoamines 2) est une protéine qui, chez les humains, est encodée par le gène situé sur le chromosome 10. C'est une protéine membranaire intégrale qui transporte des monoamines -et plus particulièrement des neurotransmetteurs comme la dopamine, la noradrénaline, la sérotonine et l'histamine- depuis le cytosol cellulaire jusqu'aux vésicules synaptiques.</span><small> (fr)</small></span></li> <li><span class="literal"><span property="rdfs:comment" lang="en" >The solute carrier family 18 member 2 (SLC18A2) also known as vesicular monoamine transporter 2 (VMAT2) is a protein that in humans is encoded by the SLC18A2 gene. SLC18A2 is an integral membrane protein that transports monoamines—particularly neurotransmitters such as dopamine, norepinephrine, serotonin, and histamine—from cellular cytosol into synaptic vesicles. In nigrostriatal pathway and mesolimbic pathway dopamine-releasing neurons, SLC18A2 function is also necessary for the vesicular release of the neurotransmitter GABA.</span><small> (en)</small></span></li> <li style="display:none;"><span class="literal"><span property="rdfs:comment" lang="pt" >O transportador vesicular de monoamina 2 (VMAT2) é uma proteína que em humanos é codificada pelo gene SLC18A2. VMAT2 é uma proteína integral de membrama que transporta monoaminas — particularmente neurotransmissores como dopamina, norepinefrina, serotonina e histamina — da matriz citoplasmática celular para as vesículas sinápticas. Na via nigroestriatal e na via mesolímbica dos neurônios liberadores de dopamina, a função do VMAT2 também é necessária para a liberação vesicular do neurotransmissor GABA.</span><small> (pt)</small></span></li> <li style="display:none;"><span class="literal"><span property="rdfs:comment" lang="de" >Der vesikuläre Monoamintransporter (VMAT, VMAT2) ist ein Protein in der Membran zytoplasmischer Vesikel innerhalb von Nervenzellen. Es erleichtert den Zufluss der Neurotransmitter Dopamin, Serotonin, Histamin und Noradrenalin in die Vesikel, bevor diese mittels Exozytose in den synaptischen Spalt entleert werden. Es handelt sich bei VMAT2 also um einen Membrantransporter, und zwar aus der Major-Facilitator-Superfamilie. VMAT2 ist nur in Wirbeltieren zu finden. Beim Menschen ist VMAT2 außer im ZNS besonders in Inselzellen und im Uterus lokalisiert. Im Pankreas spielt VMAT2 eine regulatorische Rolle bei der Insulinantwort auf Glucose.</span><small> (de)</small></span></li> <li style="display:none;"><span class="literal"><span property="rdfs:comment" lang="uk" >SLC18A2 (англ. Solute carrier family 18 member A2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 10-ї хромосоми. Довжина поліпептидного ланцюга білка становить 514 амінокислот, а молекулярна маса — 55 713. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин</span><small> (uk)</small></span></li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://www.w3.org/2000/01/rdf-schema#label"><small>rdfs:</small>label</a> </td><td class="col-10 text-break"><ul> <li style="display:none;"><span class="literal"><span property="rdfs:label" lang="ar" >ناقل أحادي الأمين الحويصلي 2</span><small> (ar)</small></span></li> <li style="display:none;"><span class="literal"><span property="rdfs:label" lang="de" >Vesikulärer Monoamintransporter</span><small> (de)</small></span></li> <li style="display:none;"><span class="literal"><span property="rdfs:label" lang="fr" >VMAT2</span><small> (fr)</small></span></li> <li style="display:none;"><span class="literal"><span property="rdfs:label" lang="pt" >Transportador vesicular de monoamina 2</span><small> (pt)</small></span></li> <li><span class="literal"><span property="rdfs:label" lang="en" >Vesicular monoamine transporter 2</span><small> (en)</small></span></li> <li style="display:none;"><span class="literal"><span property="rdfs:label" lang="uk" >SLC18A2</span><small> (uk)</small></span></li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://www.w3.org/2002/07/owl#sameAs"><small>owl:</small>sameAs</a> </td><td class="col-10 text-break"><ul> <li><span class="literal"><a class="uri" rel="owl:sameAs" resource="http://rdf.freebase.com/ns/m.02p8l28" href="http://rdf.freebase.com/ns/m.02p8l28"><small>freebase</small>:Vesicular monoamine transporter 2</a></span></li> <li><span class="literal"><a class="uri" rel="owl:sameAs" resource="http://yago-knowledge.org/resource/Vesicular_monoamine_transporter_2" 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