CINXE.COM

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href="/science/applications/research-areas/g-protein-coupled-receptors-ion-channels">G-protein-coupled Receptors & Ion Channels</a></li><li><a href="/science/applications/research-areas/post-mortem-brain-tissue">Post-mortem Brain Tissue</a></li></ul></div></div></div><div class="row menu__blocks"><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Other</div> <span class="sectitle-span">+</span><ul><li><a href="/science/applications/research-solutions/circular-rna">Circular RNA</a></li><li><a href="/science/applications/research-solutions/gene-fusions">Gene Fusions</a></li><li><a href="/science/applications/research-solutions/ngsht-transcriptomic-validation-rna-seq">HT Transcript Validation</a></li><li><a href="/science/applications/research-solutions/long-noncoding-rna">Long Non-coding RNA</a></li><li><a href="/science/applications/research-solutions/ngsht-transcriptomic-validation-rna-seq">RNAseq Validation</a></li><li><a href="/science/applications/research-solutions/single-cell-analysis">Single Cell Analysis</a></li><li><a href="/science/applications/research-solutions/splice-variant">Splice Variant</a></li><li><a href="/science/applications/research-solutions/mirna">miRNA</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">RNA & Protein</div> <span class="sectitle-span">+</span><ul><li><a href="/science/applications/research-solutions/antibody-challenges-and-validation">Antibody Challenges</a></li><li><a href="/science/applications/research-solutions/dual-ish-and-ihc">Dual ISH + IHC Methods</a></li><li><a href="/science/applications/research-solutions/no-antibodies-available">No Antibodies</a></li><li><a href="/science/applications/research-solutions/ish-and-ihc-complementary">RNA & Protein Analysis</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Customer Innovations</div> <span 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col-1"> <a href="/image-contest" class="level0">Image Calendar</a> <span class="level0 visible-xs">+</span><div class="menu-content"><div class="container"><div class="row menu__blocks"><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Image Calendar</div> <span class="sectitle-span">+</span><ul><li><a href="/image-contest">Image Contest</a></li><li><a href="/data-image-gallery">Data Image Gallery</a></li></ul></div></div></div></div></li></ul></div><div class="col-lg-1 col-md-1 col-sm-1 col-xs-12 header-search search__button "><div class="search-icon">Search</div><div class="clear"></div></div></div></div> </header></div><div class="page-main-container"><div class="region region-content"><div id="block-system-main" class="block block-system clearfix"><div class="content"><div class="banner-container sticky"> <img class="img-banner" src="https://acdbio.com/sites/default/files/science-banner.jpg"><h1 class="general-title">Leader in RNA ISH Technology for Spatial Gene Expression</h1></div><div class="content-container container custom-container science"><div class="nav-tab-container"><ul class="nav nav-tabs page-tabs" id="myTab"><li><a href="/science/technology-overview">ISH Technology</a></li><li class="active"><a href="/science/applications" class="active">Applications</a></li><li><a href="/science/why-rna">Why RNA ISH?</a></li><li><a href="/science/spotlights">Spotlights</a></li><li><a href="/science/scientific-resources/publications">Publications</a></li><li><a href="/science/posters">Posters</a></li></ul></div><div class="tab-content"><div class="container home-tab tab-pane fade in active" id="app-container"><div class="app-container"><div class="app-top"><div class="app-top-inner"><div class="app-title">RNAscope<sup>TM</sup> Applications</div><p>Biomarkers such as DNA, RNA and protein are powerful tools for understanding basic cellular functions, diagnosing clinical diseases and identifying optimal therapies. In particular, RNA is an ideal indicator of the dynamic gene expression changes that occur in an organism.</p><p>At Advanced Cell Diagnostics, we offer a revolutionary assay, capturing gene expression <em>in situ</em> at a single cell level which can be visualized within intact tissue. This provides <strong>molecular detection in a morphological context</strong> to better understand cell-to-cell interactions.</p></div></div><div class="new-app-content" id="animal-models"><div class="animal-models-wrap"><div class="row animalmodels-middle"><div class="col-md-6 col-sm-12 col-xs-12 main"><div class="app-tit"> Research Areas</div><div class="app-con"><div class="col-md-6 col-sm-6 sub-cont clear"><div class="app-sub-tit"> Cancer</div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/pdx" class="models models-to-search"> <span class="model-name">PDx</span> <span class="model-image"><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/Pdx.jpg" width="65" height="65" alt="" /></span> </a></div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/egfrviii" class="models models-to-search"> <span class="model-name">EGFRVIII</span> <span 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href="/science/applications/disease-areas/hpv-related-cancer" class="models models-to-search"> <span class="model-name">HPV RNA Detection</span> <span class="model-image"><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/HPV_0.jpg" width="65" height="65" alt="" /></span> </a></div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/immuno-oncology" class="models models-to-search"> <span class="model-name">Immuno-Oncology</span> <span class="model-image"><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/immuno.jpg" width="65" height="65" alt="" /></span> </a></div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/lung-cancer" class="models models-to-search"> <span class="model-name">Lung Cancer</span> <span class="model-image"><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/Lung.jpg" width="65" height="65" alt="" /></span> </a></div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/prostate-cancer-research" class="models models-to-search"> <span class="model-name">Prostate Cancer Research</span> <span class="model-image"><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/Prostate.jpg" width="65" height="65" alt="" /></span> </a></div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/breast-cancer" class="models models-to-search"> <span class="model-name">Breast Cancer</span> <span class="model-image"><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/Breast.jpg" width="65" height="65" alt="" /></span> </a></div></div><div class="col-md-6 col-sm-6 sub-cont "><div class="app-sub-tit"> Cell & Gene Therapy</div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/gene-therapy" class="models models-to-search"> <span class="model-name">Gene Therapy</span> <span class="model-image"><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/single-cell-analysis_0_0.jpg" width="65" height="65" alt="" /></span> </a></div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/aav-gene-therapy-biodistribution" class="models models-to-search"> <span class="model-name">AAV Biodistribution</span> <span class="model-image"></span> </a></div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/sirnaaso" class="models models-to-search"> <span class="model-name">siRNA/ASO</span> <span class="model-image"></span> </a></div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/cell-therapy" class="models models-to-search"> <span class="model-name">Cell Therapy</span> <span class="model-image"></span> </a></div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/gene-therapy-webinars" class="models models-to-search"> <span class="model-name">Gene Therapy Webinars</span> <span class="model-image"></span> </a></div></div><div class="col-md-6 col-sm-6 sub-cont clear"><div class="app-sub-tit"> Neuroscience</div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/neuroscience" class="models models-to-search"> <span class="model-name">Neuroscience</span> <span class="model-image"><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/Neuroscience.jpg" width="65" height="65" alt="" /></span> </a></div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/neuronal-cell-types" class="models models-to-search"> <span class="model-name">Neuronal Cell Types</span> <span class="model-image"><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/Neuroscience_1.jpg" width="65" height="65" alt="" /></span> </a></div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/neural-development" class="models models-to-search"> <span class="model-name">Neural Development</span> <span class="model-image"><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/Neuroscience_4.jpg" width="65" height="65" alt="" /></span> </a></div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/learning-and-memory" class="models models-to-search"> <span class="model-name">Learning and Memory</span> <span class="model-image"><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/Neuroscience_0.jpg" width="65" height="65" alt="" /></span> </a></div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/g-protein-coupled-receptors-ion-channels" class="models models-to-search"> <span class="model-name">G-protein-coupled Recepto...</span> <span class="model-image"><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/Neuroscience_1.jpg" width="65" height="65" alt="" /></span> </a></div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/post-mortem-brain-tissue" class="models models-to-search"> <span class="model-name">Post-mortem Brain Tissue</span> <span class="model-image"><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/Neuroscience_2.jpg" width="65" height="65" alt="" /></span> </a></div></div><div class="col-md-6 col-sm-6 sub-cont "><div class="app-sub-tit"> Other</div><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 models-wrap"> <a href="/science/applications/research-areas/splice-variant" class="models models-to-search"> <span 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action="https://proteinsimple--obtfull.my.salesforce.com/servlet/servlet.WebToCase?encoding=UTF-8" id="web-to-case1" method="POST"><div class="row"><div class="col-md-6"> <label for="fname">First Name</label> <input id="fname" maxlength="80" name="fname" size="20" type="text"></div><div class="col-md-6"> <label for="lname">Last Name</label> <input id="lname" maxlength="80" name="lname" size="20" type="text"></div></div><div class="row"><div class="col-md-6"> <label for="email">Email</label> <input id="email" maxlength="80" name="email" size="20" type="text"></div><div class="col-md-6"> <label for="phone">Phone</label> <input id="phone" maxlength="40" name="phone" size="20" type="text"></div></div><div class="row"><div class="col-md-6"> <label for="company">Institution / Company</label> <input id="company" maxlength="80" name="company" size="20" type="text"></div></div><div class="row"><div class="col-md-12"> <label for="description">Message</label> <textarea name="description"></textarea> </div></div><div class="row captcha"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12"> <label>Type the characters that you see in the picture below</label> <input type="text" id="PageCaseCaptcha" disabled /> <a class="btnrefresh" onclick="DrawCaptcha();"></a></div></div><div class="row captcha"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12"> <input type="text" class="case_captcha" id="PageCaseInput" name="case_captcha"/><div id="pagecasecaptcha-error"></div></div></div> <input type="submit" name="submit" style="float:left;" onclick="ValidCaptcha('pagecase');"><div class="clear"></div></form></div></div><div class="needhelp-tab-container tab-pane fade" id="contactinfo"><div class="supportform-con contact-info"><div class="row"><h3>Advanced Cell Diagnostics</h3><p>Our new headquarters office starting May 2016:</p><p>7707 Gateway Blvd. <br />Newark, CA 94560<br />Toll Free: 1 (877) 576-3636<br />Phone: (510) 576-8800<br />Fax: (510) 576-8798</p></div><div class="row"><p> </p><div class="row"><h3>Bio-Techne</h3><p>19 Barton Lane <br />Abingdon Science Park<br />Abingdon<br />OX14 3NB<br />United Kingdom<br />Phone 2: +44 1235 529449<br />Fax: +44 1235 533420</p><p> </p></div><div class="row"><h3>Advanced Cell Diagnostics China</h3><p>20F, Tower 3,<br />Raffles City Changning Office,<br />1193 Changning Road, Shanghai 200051</p><p>021-52293200<br /><a href="mailto:info.cn@bio-techne.com">info.cn@bio-techne.com</a><br />Web: <a href="http://www.acdbio.com/cn">www.acdbio.com/cn</a></p></div><div class="row"><p>For general information: <a href="mailto:Info.ACD@bio-techne.com">Info.ACD@bio-techne.com</a><br />For place an order: <a href="mailto:order.ACD@bio-techne.com">order.ACD@bio-techne.com</a><br />For product support: <a href="mailto:support.ACD@bio-techne.com">support.ACD@bio-techne.com</a><br />For career opportunities: <a href="mailto:hr.ACD@bio-techne.com">hr.ACD@bio-techne.com</a></p></div></div><div class="row" style="border-bottom: none;"><div class="col-md-6"> <a href="/about/distributors" class="meet-out-sales-team" title="See Distributors">See Distributors</a></div></div></div></div><div class="needhelp-tab-container tab-pane fade" id="contactpharma"><div class="supportform-con"><div class="contact-tab-form supportform-con"><form id="mktoForm_9817"></form> <script>MktoForms2.loadForm("//info.bio-techne.com", "584-XSF-168", 9817);</script> </div></div></div></div></div></div></div></div></div></div> <script type="text/javascript"> jQuery(document).ready(function($) { $("#web-to-case1").validate({ // Specify the validation rules rules: { fname: "required", lname: "required", phone:"required", email: { required: true, email: true }, company: "required", case_captcha: "required" }, // Specify the validation error messages messages: { fname: "Please enter your First Name", lname: "Please enter your Last Name", email: "Please enter your email address", phone: "Please enter your 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