CINXE.COM

[ { "targetId" : 2949, "targetName" : "Plasmodium falciparum dihydroorotate dehydrogenase", "ligandAsTargetId" : 0, "ligandTargetName" : null, "targetSpecies" : "Plasmodium vivax", "primaryTarget" : false, "ligandId" : 9644, "ligandName" : "DSM265", "ligandContext" : null, "type" : "Inhibitor", "action" : "Inhibition", "selectivity" : "Not Determined", "affinity" : "7.1", "affinityParameter" : "pIC50", "dataPointInteractionIds" : [ 87589 ], "refIds" : [ 40466 ] }, { "targetId" : 2949, "targetName" : "Plasmodium falciparum dihydroorotate dehydrogenase", "ligandAsTargetId" : 0, "ligandTargetName" : null, "targetSpecies" : "Plasmodium vivax", "primaryTarget" : false, "ligandId" : 11219, "ligandName" : "DSM502", "ligandContext" : null, "type" : "Inhibitor", "action" : "Inhibition", "selectivity" : "Not Determined", "affinity" : "7.8", "affinityParameter" : "pIC50", "dataPointInteractionIds" : [ 87587 ], "refIds" : [ 40466 ] }, { "targetId" : 2949, "targetName" : "Plasmodium falciparum dihydroorotate dehydrogenase", "ligandAsTargetId" : 0, "ligandTargetName" : null, "targetSpecies" : "Plasmodium vivax", "primaryTarget" : false, "ligandId" : 11554, "ligandName" : "DSM705", "ligandContext" : null, "type" : "Inhibitor", "action" : "Inhibition", "selectivity" : "Not Determined", "affinity" : "7.3", "affinityParameter" : "pIC50", "dataPointInteractionIds" : [ 88072 ], "refIds" : [ 42390 ] }, { "targetId" : 2949, "targetName" : "Plasmodium falciparum dihydroorotate dehydrogenase", "ligandAsTargetId" : 0, "ligandTargetName" : null, "targetSpecies" : "Plasmodium vivax", "primaryTarget" : true, "ligandId" : 10020, "ligandName" : "DSM421", "ligandContext" : null, "type" : "Inhibitor", "action" : "Inhibition", "selectivity" : "Selective", "affinity" : "7.0", "affinityParameter" : "pIC50", "dataPointInteractionIds" : [ 85406 ], "refIds" : [ 35352 ] }, { "targetId" : 2949, "targetName" : "Plasmodium falciparum dihydroorotate dehydrogenase", "ligandAsTargetId" : 0, "ligandTargetName" : null, "targetSpecies" : "Plasmodium vivax", "primaryTarget" : false, "ligandId" : 10020, "ligandName" : "DSM421", "ligandContext" : null, "type" : "None", "action" : "None", "selectivity" : "Not Determined", "affinity" : "6.7", "affinityParameter" : "pEC50", "dataPointInteractionIds" : [ 85412 ], "refIds" : [ 35352 ] }, { "targetId" : 2981, "targetName" : "Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase", "ligandAsTargetId" : 0, "ligandTargetName" : null, "targetSpecies" : "Plasmodium vivax", "primaryTarget" : false, "ligandId" : 9740, "ligandName" : "P218", "ligandContext" : null, "type" : "None", "action" : "None", "selectivity" : "Not Determined", "affinity" : "7.3", "affinityParameter" : "pEC50", "dataPointInteractionIds" : [ 88328 ], "refIds" : [ 43060 ] }, { "targetId" : 3059, "targetName" : "Plasmodium falciparum lysyl-tRNA synthetase", "ligandAsTargetId" : 0, "ligandTargetName" : null, "targetSpecies" : "Plasmodium vivax", "primaryTarget" : false, "ligandId" : 10398, "ligandName" : "compound 5 [PMID: 30894487]", "ligandContext" : null, "type" : "None", "action" : "None", "selectivity" : "Not Determined", "affinity" : "6.0", "affinityParameter" : "pEC50", "dataPointInteractionIds" : [ 86475 ], "refIds" : [ 37837 ] } ]