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Recent Program-Supported Publications | NIDC: National Isotope Development Center
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url(/sites/default/files/styles/manual_crop/public/2018-06/2015-P03757_4.jpg?h=d55d9bc9&itok=Jl3F1x-Q)"></div></div> </div> </div> </div> </section> </div> </div> <div role="main" class="main-container js-quickedit-main-content "> <div class="row"> <div class="highlighted container"> <div class="region region-highlighted"> <div data-drupal-messages-fallback class="hidden"></div> </div> </div> <div class="col-md-12"> <a id="main-content"></a> <div class="region region-content"> <h1 class="container" class="page-header"> <span property="schema:name">Recent Program-Supported Publications</span> </h1> <article about="/publications" typeof="schema:WebPage" class="page full clearfix"> <span property="schema:name" content="Recent Program-Supported Publications" class="hidden"></span> <div class="content"> <div property="schema:text" class="container field field--name-body field--type-text-with-summary field--label-hidden field--item"><h4><strong>The U.S. Department of Energy Isotope Program (DOE IP) supports research and development of novel methods to produce isotopes of national interest or of new or improved technologies that foster enhanced isotope production. The following research manuscripts acknowledge the DOE IP for their funding contributions.</strong></h4> <p><strong>Note: This is not a comprehensive list of publications related to the DOE IP. Our list attempts to capture all publications from 2019 and beyond.</strong></p> </div> </div> </article> <section class="views-element-container block block-views block-views-blockcontent-lists-publications clearfix container" id="block-views-block-content-lists-publications"> <div class="form-group"><div class="content-list publications view view-content-lists view-id-content_lists view-display-id-publications js-view-dom-id-1fb727736a338bd8288d2a880ada93dc75ee49cd1745266e51797599b37bc85e"> <div class="view-content"> <div class="content-list-item publication"><div class="content-list-item publication"> <img loading="eager" srcset="/sites/default/files/styles/max_325x325/public/2024-07/Screenshot%202024-07-25%20at%202.22.53%E2%80%AFPM.png?itok=uD1TRlJi 246w, /sites/default/files/styles/max_650x650/public/2024-07/Screenshot%202024-07-25%20at%202.22.53%E2%80%AFPM.png?itok=HZ4scbNw 492w, /sites/default/files/styles/max_1300x1300/public/2024-07/Screenshot%202024-07-25%20at%202.22.53%E2%80%AFPM.png?itok=WgTVaq2L 985w" sizes=" 560px) 50vw, 100vw" width="246" height="325" src="/sites/default/files/styles/max_325x325/public/2024-07/Screenshot%202024-07-25%20at%202.22.53%E2%80%AFPM.png?itok=uD1TRlJi" alt="." typeof="Image" class="img-responsive" /> <div class="content-list-information"> <h2 class="content-list-title"><a href="/node/1389" hreflang="en">Development of a 213Bi-Labeled Pyridyl Benzofuran for Targeted α-Therapy of Amyloid-β Aggregates</a></h2> <div class="content-list-date"><time datetime="2024-07-25T12:00:00Z">July 25, 2024</time> </div> <div class="content-list-body"><h6><strong>Abstract</strong></h6><p>Alzheimer disease is a neurodegenerative disorder with limited treatment options. It is characterized by the presence of several biomarkers, including amyloid-β aggregates, which lead to oxidative stress and neuronal decay. Targeted α-therapy (TAT) has been shown to be efficacious against metastatic cancer. TAT takes advantage of tumor-localized α-particle emission to break disease-associated covalent bonds while minimizing radiation dose to healthy tissues due to the short, micrometer-level, distances traveled. We hypothesized that TAT could be used to break covalent bonds within amyloid-β aggregates and facilitate natural plaque clearance mechanisms.</p></div> <div class="content-list-button"><a href="https://jnm.snmjournals.org/content/early/2024/07/25/jnumed.124.267482" class="link-button" target="_blank">View at Journal of Nuclear Medicine</a></div> </div> </div></div> <div class="content-list-item publication"><div class="content-list-item publication"> <img loading="eager" srcset="/sites/default/files/styles/max_325x325/public/2023-08/Applied%20Radiation%20and%20Isotopes.jpeg?itok=6-w2lQBw 244w, /sites/default/files/styles/max_650x650/public/2023-08/Applied%20Radiation%20and%20Isotopes.jpeg?itok=ZjcnJw07 488w, /sites/default/files/styles/max_1300x1300/public/2023-08/Applied%20Radiation%20and%20Isotopes.jpeg?itok=FgBjia3b 576w" sizes=" 560px) 50vw, 100vw" width="244" height="325" src="/sites/default/files/styles/max_325x325/public/2023-08/Applied%20Radiation%20and%20Isotopes.jpeg?itok=6-w2lQBw" alt="Applied Radiation and Isotopes" typeof="Image" class="img-responsive" /> <div class="content-list-information"> <h2 class="content-list-title"><a href="/node/1295" hreflang="en">Photonuclear production of 47Ca for 47Ca/47Sc generator from natural CaCO3 targets</a></h2> <div class="content-list-date"><time datetime="2023-08-03T12:00:00Z">August 3, 2023</time> </div> <div class="content-list-body"><h6><strong>Abstract</strong></h6><p id="abspara0010">This work investigated the indirect production of <sup>47</sup>Sc from natural Ca targets via <sup>48</sup>Ca(γ,n)<sup>47</sup>Ca→<sup>47</sup>Sc + β<sup>−</sup> + ν ¯ e with incident electron energies of 30, 35, and 40 MeV. The <sup>47</sup>Ca production yields were simulated using the PHITS Monte Carlo simulation code and compared to experimental data. The simulated production rates for all three irradiations are in good agreement with experimental data within uncertainties. As a demonstration of the <sup>47</sup>Ca/<sup>47</sup>Sc generator system, one of the irradiated CaCO<sub>3</sub> targets was dissolved in nitric acid, and <sup>47</sup>Sc was isolated from the target material using commercially available Eichrom DGA resin. The <sup>47</sup>Sc was allowed to grow in, and the purification process was repeated with promising <sup>47</sup>Sc and Ca recovery yields.</p><p> </p></div> <div class="content-list-button"><a href="https://www.sciencedirect.com/science/article/abs/pii/S0969804323002968?via%3Dihub=" class="link-button" target="_blank">View at Science Direct</a></div> </div> </div></div> <div class="content-list-item publication"><div class="content-list-item publication"> <img loading="eager" srcset="/sites/default/files/styles/max_325x325/public/2023-08/fchem-11-1204872.jpg?itok=2mY6tjFJ 255w, /sites/default/files/styles/max_650x650/public/2023-08/fchem-11-1204872.jpg?itok=a_0c6aWs 509w, /sites/default/files/styles/max_1300x1300/public/2023-08/fchem-11-1204872.jpg?itok=xV49AtVG 1019w" sizes=" 560px) 50vw, 100vw" width="255" height="325" src="/sites/default/files/styles/max_325x325/public/2023-08/fchem-11-1204872.jpg?itok=2mY6tjFJ" alt="Overviewof radiolabeling and quality control protocols for Bi-212MAA assays" typeof="Image" class="img-responsive" /> <div class="content-list-information"> <h2 class="content-list-title"><a href="/node/1296" hreflang="en">Effective therapy with Bismuth-212 labeled macroaggregated albumin in orthotopic mouse breast tumor models</a></h2> <div class="content-list-date"><time datetime="2023-05-10T12:00:00Z">May 10, 2023</time> </div> <div class="content-list-body"><p>Intravascularly administered radiation therapy using beta (β-)-emitting radioisotopes has relied on either intravenously injected radiolabeled peptides that target cancer or radiolabeled microspheres that are trapped in the tumor following intra-arterial delivery. More recently, targeted intravenous radiopeptide therapies have explored the use of alpha (α)-particle emitting radioisotopes, but microspheres radiolabeled with α-particle emitters have not yet been studied. Here, FDA-approved macroaggregated albumin (MAA) particles were radiolabeled with Bismuth-212 (Bi-212-MAA) and evaluated using clonogenic and survival assays <em>in vitro</em> and using immune-competent mouse models of breast cancer. The <em>in vivo</em> biodistribution of Bi-212-MAA was investigated in Balb/c and C57BL/6 mice with 4T1 and EO771 orthotopic breast tumors, respectively. The same orthotopic breast cancer models were used to evaluate the treatment efficacy of Bi-212-MAA. Our results showed that macroaggregated albumin can be stably radiolabeled with Bi-212 and that Bi-212-MAA can deliver significant radiation therapy to reduce the growth and clonogenic potential of 4T1 and EO771 cells <em>in vitro</em>. Additionally, Bi-212-MAA treatment upregulated γH2AX and cleaved Caspase-3 expression in 4T1 cells. Biodistribution analyses showed 87–93% of the Bi-212-MAA remained in 4T1 and EO771 tumors 2 and 4 h after injection. Following single-tumor treatments with Bi-212-MAA there was a significant reduction in the growth of both 4T1 and EO771 breast tumors over the 18-day monitoring period. Overall, these findings showed that Bi-212-MAA was stably radiolabeled and inhibited breast cancer growth. Bi-212-MAA is an exciting platform to study α-particle therapy and will be easily translatable to larger animal models and human clinical trials.</p> <p> </p></div> <div class="content-list-button"><a href="https://www.frontiersin.org/articles/10.3389/fchem.2023.1204872/full" class="link-button" target="_blank">View at Frontiers in Chemistry</a></div> </div> </div></div> <div class="content-list-item publication"><div class="content-list-item publication"> <img loading="eager" srcset="/sites/default/files/styles/max_325x325/public/2022-01/mpohbp.2021.18.issue-12.largecover.jpg?itok=TwhnGMaP 244w, /sites/default/files/styles/max_650x650/public/2022-01/mpohbp.2021.18.issue-12.largecover.jpg?itok=11vC4Qtt 298w" sizes=" 560px) 50vw, 100vw" width="244" height="325" src="/sites/default/files/styles/max_325x325/public/2022-01/mpohbp.2021.18.issue-12.largecover.jpg?itok=TwhnGMaP" alt="Evaluation of 177 Lu and 47 Sc Picaga-Linked" typeof="Image" class="img-responsive" /> <div class="content-list-information"> <h2 class="content-list-title"><a href="/publications/Evaluation_of_177_Lu_and_47_Sc_Picaga-Linked_Prostate-Specific_Membrane_Antigen-Targeting_Constructs_for_Their_Radiotherapeutic_Efficacy_and_Dosimetry" hreflang="en">Evaluation of 177 Lu and 47 Sc Picaga-Linked, Prostate-Specific Membrane Antigen-Targeting Constructs for Their Radiotherapeutic Efficacy and Dosimetry</a></h2> <div class="content-list-date"><time datetime="2022-01-20T12:00:00Z">January 20, 2022</time> </div> <div class="content-list-body"><h2>Abstract</h2> <p>Lu-177-based, targeted radiotherapeutics/endoradiotherapies are an emerging clinical tool for the management of various cancers. The chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) remains the workhorse for such applications but can limit apparent molar activity or efficient charge modulation, which can impact target binding and, as a consequence, target efficacy. Previously, our lab had developed the small, rare earth selective bifunctional chelator, picaga, as an efficient bifunctional chelator for scandium and lutetium isotopes. Here, we assess the performance of these constructs for therapy in prostate-specific membrane antigen (PSMA)-expressing tumor xenografts. To assess the viability of picaga conjugates in conjunction with long in vivo circulation, a picaga conjugate functionalized with a serum albumin binding moiety, <sup>177</sup>Lu-picaga-Alb53-PSMA, was also synthesized. A directly comparative, low, single 3.7 MBq dose treatment study with Lu-PSMA-617 was conducted. Treatment with <sup>177</sup>Lu-picaga-Alb53-PSMA resulted in tumor regression and lengthened median survival (54 days) when compared with the vehicle (16 days), <sup>47</sup>Sc-picaga-DUPA-, <sup>177</sup>Lu-picaga-DUPA-, and <sup>177</sup>Lu-PSMA-617-treated cohorts (21, 23, and 21 days, respectively).</p></div> <div class="content-list-button"><a href="https://pubmed.ncbi.nlm.nih.gov/34714082/" class="link-button" target="_blank">View at </a></div> </div> </div></div> <div class="content-list-item publication"><div class="content-list-item publication"> <img loading="eager" srcset="/sites/default/files/styles/max_325x325/public/2021-06/Applied%20Radiation%20and%20Isotopes2.jpg?itok=_jO_RpZO 244w, /sites/default/files/styles/max_650x650/public/2021-06/Applied%20Radiation%20and%20Isotopes2.jpg?itok=_aWb-mie 488w, /sites/default/files/styles/max_1300x1300/public/2021-06/Applied%20Radiation%20and%20Isotopes2.jpg?itok=YUmx7VPP 576w" sizes=" 560px) 50vw, 100vw" width="244" height="325" src="/sites/default/files/styles/max_325x325/public/2021-06/Applied%20Radiation%20and%20Isotopes2.jpg?itok=_jO_RpZO" alt="Nuclear data for reactor production of Ba-131 and Ba-133" typeof="Image" class="img-responsive" /> <div class="content-list-information"> <h2 class="content-list-title"><a href="/nuclear-data-for-reactor-production-of-Ba-131-and-Ba-133" hreflang="en">Nuclear data for reactor production of Ba-131 and Ba-133</a></h2> <div class="content-list-date"><time datetime="2021-06-01T12:00:00Z">June 1, 2021</time> </div> <div class="content-list-body"><p>The newest radioisotope for <a href="https://www.sciencedirect.com/topics/physics-and-astronomy/brachytherapy" title="Learn more about brachytherapy from ScienceDirect's AI-generated Topic Pages">brachytherapy</a> treatment of prostate cancer is <sup>131</sup>Cs (t<sub>1/2</sub> = 9.69 d, 100% EC). Generated via electron capture decay of <sup>131</sup>Ba (t<sub>1/2</sub> = 11.6 d, 100% EC), <sup>131</sup>Cs has been used in brachytherapy for prostate cancer since 2004. The <sup>131</sup>Ba parent is produced through neutron capture of enriched <sup>130</sup>Ba in a nuclear reactor. For large-scale production of <sup>131</sup>Ba, an accurate knowledge of production and burnup cross sections of <sup>131</sup>Ba are essential. In this paper, we report two group cross sections (thermal and resonance integrals) for <sup>130</sup>Ba and <sup>131</sup>Ba and a new measure of the half-life of <sup>131</sup>Ba. Targets consisting of milligram quantities of enriched <sup>130</sup>Ba (∼35%) were irradiated in Oak Ridge National Laboratory's High Flux Isotope Reactor at thermal and resonance neutron fluxes of (1.9–2.1) × 10<sup>15</sup> and (5.8–7.0) × 10<sup>13</sup> neutrons·cm<sup>−2</sup> s<sup>−1</sup>, respectively, for durations ranging from 3 to 26 days. In addition, cadmium covered samples of <sup>130</sup>Ba were irradiated for 1 hour at 12.6% full reactor power (10.7 MW). The yield of <sup>131</sup>Ba approaches a saturation value of ∼60 GBq (∼1.6 Ci) per mg of <sup>130</sup>Ba for 20 days irradiation at a thermal neutron flux of 1.8 × 10<sup>15</sup> n·s<sup>−1</sup>·cm<sup>−2</sup>, with a thermal/epithermal ratio of ∼30. Under the above experimental conditions, the two group cross sections of <sup>130</sup>Ba are 6.9 ± 0.5 b (thermal, σ<sup>0</sup>) and 173 ± 7 b (resonance, I<sup>0</sup>). These values represent the sum of cross sections to metastable and ground states of <sup>131</sup>Ba. For <sup>131</sup>Ba, the empirically measured thermal cross section is 200 ± 50 b assuming an I<sup>0</sup>/σ<sup>0</sup> of 10. This cross section is reported for the first time. Further, the half-life of <sup>131</sup>Ba was remeasured to be 11.657 ± 0.008 d. Lastly, this study also resulted in the co-production of <sup>133</sup>Ba (t<sub>1/2</sub> = 10.52 y, 100% <em>EC</em>). The experimental yield of <sup>133</sup>Ba is ∼370 MBq (∼10 mCi) per mg of <sup>132</sup>Ba (thin target) for one cycle irradiation in the High Flux Isotope Reactor, and measured two-group <sup>132</sup>Ba cross sections are 7.2 ± 0.2 b and 39.9 ± 1.3 b. These values also represent the sum of cross sections to metastable and ground states of <sup>133</sup>Ba.</p> </div> <div class="content-list-button"><a href="https://www.sciencedirect.com/science/article/abs/pii/S0969804321000567?dgcid=rss_sd_all" class="link-button" target="_blank">View at Science Direct</a></div> </div> </div></div> <div class="content-list-item publication"><div class="content-list-item publication"> <img loading="eager" srcset="/sites/default/files/styles/max_325x325/public/2021-05/Pages%20from%20Akam2021_Article_VisionsByWomenInMolecularImagi.jpg?itok=bdLFwhuB 245w, /sites/default/files/styles/max_650x650/public/2021-05/Pages%20from%20Akam2021_Article_VisionsByWomenInMolecularImagi.jpg?itok=yZyC5X0i 489w, /sites/default/files/styles/max_1300x1300/public/2021-05/Pages%20from%20Akam2021_Article_VisionsByWomenInMolecularImagi.jpg?itok=v4a6t1qy 979w" sizes=" 560px) 50vw, 100vw" width="245" height="325" src="/sites/default/files/styles/max_325x325/public/2021-05/Pages%20from%20Akam2021_Article_VisionsByWomenInMolecularImagi.jpg?itok=bdLFwhuB" alt="Visions by Women in Molecular Imaging Network: Antiracism and Allyship in Action" typeof="Image" class="img-responsive" /> <div class="content-list-information"> <h2 class="content-list-title"><a href="/visions_by_women_in_molecular_imaging_network%3A_antiracism_and_allyship_in_action" hreflang="en">Visions by Women in Molecular Imaging Network: Antiracism and Allyship in Action</a></h2> <div class="content-list-date"><time datetime="2021-03-22T12:00:00Z">March 22, 2021</time> </div> <div class="content-list-body"><p>Recent events in America in 2020 have stimulated a worldwide movement to dismantle anti-Black racism in all facets of our lives. Anti-Black racism is, as defined by the Movement for Black Lives, a “term used to specifically describe the unique discrimination, violence, and harm imposed on and impacting Black people specifically.” In science, technology, engineering, and mathematics (STEM), we have yet to achieve the goal and responsibility to ensure that the field reflects the diversity of our lived experiences. Members of the Women in Molecular Imaging Network (WIMIN) have come together to take a stand on diversity, equity, and inclusion in the field of molecular imaging. We strongly condemn oppression in all its forms and strive to identify and dismantle barriers that lead to inequities in the molecular imaging community and STEM as a whole. In this series coined “Visions” (Antiracism and Allyship in Action), we identify and discuss specific actionable items for improving diversity and representation in molecular imaging and ensuring inclusion of all members of the community, inclusive of race, disability, ethnicity, religion, or LGBTQ+ identity. Although the issues highlighted here extend to other under-recruited and equity-seeking groups, for this first article, we are focusing on one egregious and persistent form of discrimination: anti-Black racism. In this special article, Black women residing in America present their lived experiences in the molecular imaging field and give candid insights into the challenges, frustrations, and hopes of our Black friends and colleagues. While this special article focuses on the experiences of Black women, we would like the readers to reflect on their anti-Blackness toward men, transgender, nonbinary, and gender non-conforming people. From the vulnerability we have asked of all our participants, these stories are meant to inspire and invoke active antiracist work among the readership. We present strategies for dismantling systemic racism that research centers and universities can implement in the recruitment, retention, mentorship, and development of Black trainees and professionals. We would like to specifically acknowledge the Black women who took the time to be interviewed, write perspectives, and share their lived experiences in hopes that it will inspire genuine and lasting change.</p> </div> <div class="content-list-button"><a href="https://link.springer.com/article/10.1007/s11307-021-01597-x" class="link-button" target="_blank">View at Molecular Imaging and Biology</a></div> </div> </div></div> <div class="content-list-item publication"><div class="content-list-item publication"> <img loading="eager" srcset="/sites/default/files/styles/max_325x325/public/2021-05/Pages%20from%20PhysRevC.103.034601.jpg?itok=k659bzPE 242w, /sites/default/files/styles/max_650x650/public/2021-05/Pages%20from%20PhysRevC.103.034601.jpg?itok=Knk0cVBS 484w, /sites/default/files/styles/max_1300x1300/public/2021-05/Pages%20from%20PhysRevC.103.034601.jpg?itok=D0V-7sR8 968w" sizes=" 560px) 50vw, 100vw" width="242" height="325" src="/sites/default/files/styles/max_325x325/public/2021-05/Pages%20from%20PhysRevC.103.034601.jpg?itok=k659bzPE" alt="Investigating high-energy proton-induced reactions on spherical nuclei: Implications for the preequilibrium exciton model" typeof="Image" class="img-responsive" /> <div class="content-list-information"> <h2 class="content-list-title"><a href="/investigating_high-energy_proton-induced_reactions_on_spherical_nuclei%3A_Implications_for_the_preequilibrium_exciton_model" hreflang="en">Investigating high-energy proton-induced reactions on spherical nuclei: Implications for the preequilibrium exciton model</a></h2> <div class="content-list-date"><time datetime="2021-03-01T12:00:00Z">March 1, 2021</time> </div> <div class="content-list-body"><p>A number of accelerator-based isotope production facilities utilize 100- to 200-MeV proton beams due to the high production rates enabled by high-intensity beam capabilities and the greater diversity of isotope production brought on by the long-range of high-energy protons. However, nuclear reaction modeling at these energies can be challenging because of the interplay between different reaction modes and a lack of existing guiding cross-section data.</p> </div> <div class="content-list-button"><a href="https://journals.aps.org/prc/abstract/10.1103/PhysRevC.103.034601" class="link-button" target="_blank">View at Physical Review</a></div> </div> </div></div> <div class="content-list-item publication"><div class="content-list-item publication"> <img loading="eager" srcset="/sites/default/files/styles/max_325x325/public/2021-05/Nuclear%20Medicine%20and%20Biology.jpg?itok=BloQucr2 244w, /sites/default/files/styles/max_650x650/public/2021-05/Nuclear%20Medicine%20and%20Biology.jpg?itok=pispbbuU 488w, /sites/default/files/styles/max_1300x1300/public/2021-05/Nuclear%20Medicine%20and%20Biology.jpg?itok=j48zhres 576w" sizes=" 560px) 50vw, 100vw" width="244" height="325" src="/sites/default/files/styles/max_325x325/public/2021-05/Nuclear%20Medicine%20and%20Biology.jpg?itok=BloQucr2" alt="Radioarsenic: A promising theragnostic candidate for nuclear medicine" typeof="Image" class="img-responsive" /> <div class="content-list-information"> <h2 class="content-list-title"><a href="/radioarsenic%3A_a_promising_theragnostic_candidate_for_nuclear_medicine" hreflang="en">Radioarsenic: A promising theragnostic candidate for nuclear medicine</a></h2> <div class="content-list-date"><time datetime="2021-01-11T12:00:00Z">January 11, 2021</time> </div> <div class="content-list-body"><p>Molecular imaging is a non-invasive process that enables the visualization, characterization, and quantitation of biological processes at the molecular and cellular level. With the emergence of theragnostic agents to diagnose and treat disease for personalized medicine there is a growing need for matched pairs of isotopes. Matched pairs offer the unique opportunity to obtain patient specific information from SPECT or PET diagnostic studies to quantitate <em>in vivo</em> function or receptor density to inform and tailor therapeutic treatment. There are several isotopes of arsenic that have emissions suitable for either or both diagnostic imaging and radiotherapy. Their half-lives are long enough to pair them with peptides and antibodies which take longer to reach maximum uptake to facilitate improved patient pharmacokinetics and dosimetry then can be obtained with shorter lived radionuclides. Arsenic-72 even offers availability from a generator that can be shipped to remote sites and thus enhances availability. Arsenic has a long history as a diagnostic agent, but until recently has suffered from limited availability, lack of suitable chelators, and concerns about toxicity have inhibited its use in nuclear medicine. However, new production methods and novel chelators are coming online and the use of radioarsenic in the pico and nanomolar scale is well below the limits associated with toxicity. This manuscript will review the production routes, separation chemistry, radiolabeling techniques and <em>in vitro</em>/<em>in vivo</em> studies of three medically relevant isotopes of arsenic (arsenic-74, arsenic-72, and arsenic-77).</p> </div> <div class="content-list-button"><a href="https://www.sciencedirect.com/science/article/pii/S0969805120300639?via%3Dihub=" class="link-button" target="_blank">View at Nuclear Medicine and Biology</a></div> </div> </div></div> <div class="content-list-item publication"><div class="content-list-item publication"> <img loading="eager" srcset="/sites/default/files/styles/max_325x325/public/2021-05/Nuclear%20Medicine%20and%20Biology_0.jpg?itok=MjbbmOYE 244w, /sites/default/files/styles/max_650x650/public/2021-05/Nuclear%20Medicine%20and%20Biology_0.jpg?itok=Jpk3HWIS 488w, /sites/default/files/styles/max_1300x1300/public/2021-05/Nuclear%20Medicine%20and%20Biology_0.jpg?itok=bPu08zA5 576w" sizes=" 560px) 50vw, 100vw" width="244" height="325" src="/sites/default/files/styles/max_325x325/public/2021-05/Nuclear%20Medicine%20and%20Biology_0.jpg?itok=MjbbmOYE" alt="Alpha emitting nuclides for targeted therapy" typeof="Image" class="img-responsive" /> <div class="content-list-information"> <h2 class="content-list-title"><a href="/alpha_emitting_nuclides_for_targeted_therapy" hreflang="en">Alpha emitting nuclides for targeted therapy</a></h2> <div class="content-list-date"><time datetime="2021-01-04T12:00:00Z">January 4, 2021</time> </div> <div class="content-list-body"><p>Targeted alpha therapy (TAT) is an area of research with rapidly increasing importance as the emitted alpha particle has a significant effect on inducing cytotoxic effects on tumor cells while mitigating dose to normal tissues. Two significant isotopes of interest within the area of TAT are thorium-227 and actinium-225 due to their nuclear characteristics. Both isotopes have physical half-lives suitable for coordination with larger biomolecules, and additionally actinium-225 has potential to serve as an in vivo generator. In this review, the authors will discuss the production, purification, labeling reactions, and biological studies of actinium-225 and thorium-227 complexes and clinical studies.</p> </div> <div class="content-list-button"><a href="https://www.sciencedirect.com/science/article/pii/S0969805120302146?via%3Dihub=" class="link-button" target="_blank">View at Nuclear Medicine and Biology</a></div> </div> </div></div> <div class="content-list-item publication"><div class="content-list-item publication"> <img loading="eager" srcset="/sites/default/files/styles/max_325x325/public/2021-05/New%20Journal%20of%20Chemisty%20Article%20-%20MSU%202020.png?itok=_rStX1GG 148w" sizes=" 560px) 50vw, 100vw" width="148" height="195" src="/sites/default/files/styles/max_325x325/public/2021-05/New%20Journal%20of%20Chemisty%20Article%20-%20MSU%202020.png?itok=_rStX1GG" alt="New Journal of Chemistry" typeof="Image" class="img-responsive" /> <div class="content-list-information"> <h2 class="content-list-title"><a href="/new_journal_of_chemistry_msu2020" hreflang="en">Harvesting 62Zn from an aqueous cocktail at the NSCL</a></h2> <div class="content-list-date"><time datetime="2020-11-16T12:00:00Z">November 16, 2020</time> </div> <div class="content-list-body"><p xmlns="http://www.rsc.org/schema/rscart38">“Isotope harvesting” is a technique that offers access to exotic radionuclides created as by-products during nuclear science research. Ongoing exploratory work at the National Superconducting Cyclotron Laboratory (NSCL) is directed towards the production and extraction of rare radionuclides from a flowing-water target and intends to pave the way for future harvesting efforts at the upcoming Facility for Rare Isotope Beams (FRIB). Here we present the collection of <small><sup>62</sup></small>Zn from an aqueous matrix irradiated with a 150 MeV per nucleon <small><sup>78</sup></small>Kr beam, while synergistically capturing other gaseous reaction products. In addition to the production rate for <small><sup>62</sup></small>Zn (9.08(30) × 10<small><sup>−5 62</sup></small>Zn per incoming <small><sup>78</sup></small>Kr), the rates of formation for several other radionuclides were determined as well. The purification of <small><sup>62</sup></small>Zn from a large number of co-produced radionuclides was performed by anion exchange chromatography, allowing the isolation of 80.5(5.2)% of the generated <small><sup>62</sup></small>Zn. With the decay of <small><sup>62</sup></small>Zn the radioactive daughter <small><sup>62</sup></small>Cu is generated, and with the isolation of pure <small><sup>62</sup></small>Cu eluate, the principle of a medical radionuclide generator could be demonstrated. To illustrate the applicability of the obtained <small><sup>62</sup></small>Zn, the isolated product was used in free and DTPA-labelled form in a proof of principle plant uptake study with garden cress employing phosphor imaging for visualization.</p> </div> <div class="content-list-button"><a href="https://doi.org/10.1039/D0NJ04411C" class="link-button" target="_blank">View at New Journal of Chemistry</a></div> </div> </div></div> </div> <nav class="pager-nav text-center" role="navigation" aria-labelledby="pagination-heading"> <h4 id="pagination-heading" class="visually-hidden">Pagination</h4> <ul class="pagination js-pager__items"> <li class="pager__item is-active active"> <a href="?page=0" title="Current page" aria-current="page"> <span class="visually-hidden"> Current page </span>1</a> </li> <li class="pager__item"> <a href="?page=1" title="Go to page 2"> <span class="visually-hidden"> Page </span>2</a> </li> <li class="pager__item"> <a href="?page=2" title="Go to page 3"> <span 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