Arrhythmogenic right ventricular cardiomyopathy: MedlinePlus Genetics

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<h1>Arrhythmogenic right ventricular cardiomyopathy</h1> </div> <div class="page-actions"></div> <noscript><span class="js-disabled-message">To use the sharing features on this page, please enable JavaScript.</span></noscript> </div> <div class="main"> <div class="mp-exp exp-full" data-bookmark="description"> <h2>Description</h2> <section><div class="mp-content"><p>Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a form of heart disease that usually appears in adulthood. ARVC is a disorder of the myocardium, which is the muscular wall of the heart. This condition causes part of the myocardium to break down over time, increasing the risk of an abnormal heartbeat (arrhythmia) and sudden death.</p><p>ARVC may not cause any symptoms in its early stages. However, affected individuals may still be at risk of sudden death, especially during strenuous exercise. When symptoms occur, they most commonly include a sensation of fluttering or pounding in the chest (palpitations), light-headedness, and fainting (syncope). Over time, ARVC can also cause shortness of breath and abnormal swelling in the legs or abdomen. If the myocardium becomes severely damaged in the later stages of the disease, it can lead to heart failure.</p></div> </section> </div> <div class="mp-exp exp-full" data-bookmark="frequency"> <h2>Frequency</h2> <section><div class="mp-content"><p>ARVC occurs in an estimated 1 in 1,000 to 1 in 1,250 people. This disorder may be underdiagnosed because it can be difficult to detect in people with mild or no symptoms.</p></div> </section> </div> <div class="mp-exp exp-full" data-bookmark="causes"> <h2>Causes</h2> <section><div class="mp-content"><p>ARVC can result from mutations in at least 13 genes. Many of these genes are known as desmosomal genes because they provide instructions for making components of cell structures called desmosomes. Desmosomes attach heart muscle cells to one another, providing strength to the myocardium and playing a role in signaling between neighboring cells.</p><p>Mutations in desmosomal genes impair the function of desmosomes. Without normal desmosomes, cells of the myocardium detach from one another and die, particularly when the heart muscle is placed under stress (such as during vigorous exercise). These changes primarily affect the myocardium surrounding the right ventricle, one of the two lower chambers of the heart. The damaged myocardium is gradually replaced by fat and scar tissue. As this abnormal tissue builds up, the walls of the right ventricle become stretched out, preventing the heart from pumping blood effectively. These changes also disrupt the electrical signals that control the heartbeat, which can lead to arrhythmia.</p><p>Less commonly, mutations in non-desmosomal genes can cause ARVC. These genes have a variety of functions, including cell signaling, providing structure and stability to heart muscle cells, and helping to maintain a normal heart rhythm. Researchers are working to determine how mutations in non-desmosomal genes can lead to ARVC.</p><p>Gene mutations have been found in about 60 percent of people with ARVC. Mutations in a desmosomal gene called <i><a data-pid="18445" href="https://medlineplus.gov/genetics/gene/pkp2/">PKP2</a></i> appear to be most common. In people without an identified mutation, the cause of the disorder is unknown. Researchers are looking for additional genetic factors that play a role in causing ARVC.</p></div> </section> <section> <div class="related-genes mp-exp exp-full"> <h3>Learn more about the genes associated with Arrhythmogenic right ventricular cardiomyopathy</h3> <ul class="relatedmp"> <li><a href="https://medlineplus.gov/genetics/gene/des/">DES</a></li> <li><a href="https://medlineplus.gov/genetics/gene/dsc2/">DSC2</a></li> <li><a href="https://medlineplus.gov/genetics/gene/dsp/">DSP</a></li> <li><a href="https://medlineplus.gov/genetics/gene/jup/">JUP</a></li> <li><a href="https://medlineplus.gov/genetics/gene/lmna/">LMNA</a></li> <li><a href="https://medlineplus.gov/genetics/gene/pkp2/">PKP2</a></li> <li><a href="https://medlineplus.gov/genetics/gene/ryr2/">RYR2</a></li> <li><a href="https://medlineplus.gov/genetics/gene/tgfb3/">TGFB3</a></li> <li><a href="https://medlineplus.gov/genetics/gene/ttn/">TTN</a></li> </ul> <p><strong>Additional Information from NCBI Gene:</strong></p> <ul class="relatedmp"> <li><a href="https://www.ncbi.nlm.nih.gov/gene/29119" target="TheNewWin">CTNNA3</a></li> <li><a href="https://www.ncbi.nlm.nih.gov/gene/1829" target="TheNewWin">DSG2</a></li> <li><a href="https://www.ncbi.nlm.nih.gov/gene/5350" target="TheNewWin">PLN</a></li> <li><a href="https://www.ncbi.nlm.nih.gov/gene/79188" target="TheNewWin">TMEM43</a></li> </ul> </div> </section> </div> <div class="mp-exp exp-full" data-bookmark="inheritance"> <h2>Inheritance</h2> <section><div class="mp- mp-content"><p>Up to half of all cases of ARVC appear to run in families. Most familial cases of the disease have an <a class="image-modal" data-alt="A parent with an autosomal dominant condition passes the altered gene to two affected children. Two other children do not receive the altered gene, and are unaffected." data-caption="" data-credit="U.S. National Library of Medicine" data-filepath="images/PX00009C_PRESENTATION.jpeg" data-imgtype="genetics" data-pix="PX00009C" data-sourceurl="" data-title="Autosomal dominant inheritance" href="https://medlineplus.gov/images/PX00009C_PRESENTATION.jpeg" id="PX00009C_1" title="Show image">autosomal dominant pattern<img alt="" aria-hidden="true" class="image-modal-icon" src="https://medlineplus.gov/css/img/icon_camera_small.png"/></a> of inheritance, which means one copy of an altered gene in each cell is sufficient to cause the disorder.</p><p>Rarely, ARVC has an <a class="image-modal" data-alt="Both parents carry one copy of a mutated gene. In the next generation, one child is affected with the condition, two children are carriers, and one is unaffected and not a carrier." data-caption="" data-credit="U.S. National Library of Medicine" data-filepath="images/PX0000A4_PRESENTATION.jpeg" data-imgtype="genetics" data-pix="PX0000A4" data-sourceurl="" data-title="Autosomal recessive inheritance" href="https://medlineplus.gov/images/PX0000A4_PRESENTATION.jpeg" id="PX0000A4_2" title="Show image">autosomal recessive pattern<img alt="" aria-hidden="true" class="image-modal-icon" src="https://medlineplus.gov/css/img/icon_camera_small.png"/></a> of inheritance, which means both copies of a gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.</p></div> </section> </div> <div class="mp-exp exp-full" data-bookmark="synonyms"> <h2>Other Names for This Condition</h2> <section> <ul class="bulletlist"> <li>Arrhythmogenic right ventricular cardiomyopathy-dysplasia</li> <li>Arrhythmogenic right ventricular dysplasia</li> <li>Arrhythmogenic right ventricular dysplasia/cardiomyopathy</li> <li>ARVC</li> <li>ARVD</li> <li>ARVD/C</li> <li>Right ventricular dysplasia, arrhythmogenic</li> <li>Ventricular dysplasia, right, arrhythmogenic</li> </ul> </section> </div> <div class="mp-exp exp-full" data-bookmark="resources"> <h2>Additional Information & Resources</h2> <section> <div class="mp-content"> <h2>Genetic Testing Information</h2> <ul> <li><a href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C0349788/" target="TheNewWin">Genetic Testing Registry: Arrhythmogenic right ventricular cardiomyopathy</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> <li><a href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C3552311/" target="TheNewWin">Genetic Testing Registry: Arrhythmogenic right ventricular dysplasia, familial, 11, with mild palmoplantar keratoderma and woolly hair</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> <li><a href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C1836704/" target="TheNewWin">Genetic Testing Registry: Arrhythmogenic right ventricular dysplasia, familial, 7</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> <li><a href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C1862511/" target="TheNewWin">Genetic Testing Registry: Arrhythmogenic right ventricular dysplasia 1</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> <li><a href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C1857777/" target="TheNewWin">Genetic Testing Registry: Arrhythmogenic right ventricular dysplasia 10</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> <li><a href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C1864850/" target="TheNewWin">Genetic Testing Registry: Arrhythmogenic right ventricular dysplasia 11</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> <li><a href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C1969081/" target="TheNewWin">Genetic Testing Registry: Arrhythmogenic right ventricular dysplasia 12</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> <li><a href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C3810138/" target="TheNewWin">Genetic Testing Registry: Arrhythmogenic right ventricular dysplasia 13</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> <li><a href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C1832931/" target="TheNewWin">Genetic Testing Registry: Arrhythmogenic right ventricular dysplasia 2</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> <li><a href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C1865882/" target="TheNewWin">Genetic Testing Registry: Arrhythmogenic right ventricular dysplasia 3</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> <li><a href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C1865881/" target="TheNewWin">Genetic Testing Registry: Arrhythmogenic right ventricular dysplasia 4</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> <li><a href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C1858379/" target="TheNewWin">Genetic Testing Registry: Arrhythmogenic right ventricular dysplasia 5</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> <li><a href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C1858378/" target="TheNewWin">Genetic Testing Registry: Arrhythmogenic right ventricular dysplasia 6</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> <li><a href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C1843896/" target="TheNewWin">Genetic Testing Registry: Arrhythmogenic right ventricular dysplasia 8</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> <li><a href="https://www.ncbi.nlm.nih.gov/gtr/conditions/C1836906/" target="TheNewWin">Genetic Testing Registry: Arrhythmogenic right ventricular dysplasia 9</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> </ul> </div> </section> <section> <div class="mp-content"> <h2>Genetic and Rare Diseases Information Center</h2> <ul> <li><a href="https://rarediseases.info.nih.gov/diseases/5847/index" target="TheNewWin">Arrhythmogenic right ventricular cardiomyopathy</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> </ul> </div> </section> <section> <div class="mp-content"> <h2>Patient Support and Advocacy Resources</h2> <ul> <li><a href="https://rarediseases.org/" target="TheNewWin">National Organization for Rare Disorders (NORD)</a></li> </ul> </div> </section> <section> <div class="mp-content"> <h2>Clinical Trials</h2> <ul> <li><a href="https://clinicaltrials.gov/search?cond=%22Arrhythmogenic right ventricular cardiomyopathy%22" target="TheNewWin">ClinicalTrials.gov</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> </ul> </div> </section> <section> <div class="mp-content"> <h2>Catalog of Genes and Diseases from OMIM</h2> <ul> <li><a href="https://omim.org/entry/107970" target="TheNewWin">ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 1; ARVD1</a></li> <li><a href="https://omim.org/entry/602086" target="TheNewWin">ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 3; ARVD3</a></li> <li><a href="https://omim.org/entry/602087" target="TheNewWin">ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 4; ARVD4</a></li> <li><a href="https://omim.org/entry/604772" target="TheNewWin">VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY; CPVT1</a></li> <li><a href="https://omim.org/entry/604400" target="TheNewWin">ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 5; ARVD5</a></li> <li><a href="https://omim.org/entry/604401" target="TheNewWin">ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 6; ARVD6</a></li> <li><a href="https://omim.org/entry/607450" target="TheNewWin">ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 8; ARVD8</a></li> <li><a href="https://omim.org/entry/610193" target="TheNewWin">ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 10; ARVD10</a></li> <li><a href="https://omim.org/entry/611528" target="TheNewWin">ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 12; ARVD12</a></li> <li><a href="https://omim.org/entry/609040" target="TheNewWin">ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 9; ARVD9</a></li> <li><a href="https://omim.org/entry/610476" target="TheNewWin">ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 11; ARVD11</a></li> <li><a href="https://omim.org/entry/615616" target="TheNewWin">ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 13; ARVD13</a></li> </ul> </div> </section> <section> <div class="mp-content"> <h2>Scientific Articles on PubMed</h2> <ul> <li><a href="https://pubmed.ncbi.nlm.nih.gov/?term=%28Arrhythmogenic+Right+Ventricular+Dysplasia%5BMAJR%5D%29+AND+%28%28arrhythmogenic+right+ventricular+cardiomyopathy%5BTIAB%5D%29+OR+%28arrhythmogenic+right+ventricular+dysplasia%5BTIAB%5D%29%29+AND+english%5Bla%5D+AND+human%5Bmh%5D+AND+%22last+1800+days%22%5Bdp%5D" target="TheNewWin">PubMed</a> <span class="desc-text"><img alt="From the National Institutes of Health" title="From the National Institutes of Health" src="https://medlineplus.gov/images/nih.png" class="imgdesc" width="25" height="16"></span></li> </ul> </div> </section> </div> <div class="mp-exp exp-full" data-bookmark="references"> <h2>References</h2> <section> <div class="mp-content"> <ul> <li>Corrado D, Link MS, Calkins H. Arrhythmogenic Right Ventricular Cardiomyopathy. N Engl J Med. 2017 Jan 5;376(1):61-72. doi: 10.1056/NEJMra1509267. No abstract available. <a href="https://pubmed.ncbi.nlm.nih.gov/28052233" target="TheNewWin">Citation on PubMed</a></li> <li>Corrado D, Wichter T, Link MS, Hauer RN, Marchlinski FE, Anastasakis A, Bauce B, Basso C, Brunckhorst C, Tsatsopoulou A, Tandri H, Paul M, Schmied C, Pelliccia A, Duru F, Protonotarios N, Estes NM 3rd, McKenna WJ, Thiene G, Marcus FI, Calkins H. Treatment of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: An International Task Force Consensus Statement. Circulation. 2015 Aug 4;132(5):441-53. doi: 10.1161/CIRCULATIONAHA.115.017944. Epub 2015 Jul 27. <a href="https://pubmed.ncbi.nlm.nih.gov/26216213" target="TheNewWin">Citation on PubMed</a> or <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521905/" target="TheNewWin">Free article on PubMed Central</a></li> <li>Marcus FI, McKenna WJ, Sherrill D, Basso C, Bauce B, Bluemke DA, Calkins H, Corrado D, Cox MG, Daubert JP, Fontaine G, Gear K, Hauer R, Nava A, Picard MH, Protonotarios N, Saffitz JE, Sanborn DM, Steinberg JS, Tandri H, Thiene G, Towbin JA, Tsatsopoulou A, Wichter T, Zareba W. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria. Circulation. 2010 Apr 6;121(13):1533-41. doi: 10.1161/CIRCULATIONAHA.108.840827. Epub 2010 Feb 19. <a href="https://pubmed.ncbi.nlm.nih.gov/20172911" target="TheNewWin">Citation on PubMed</a> or <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860804/" target="TheNewWin">Free article on PubMed Central</a></li> <li>McNally E, MacLeod H, Dellefave-Castillo L. Arrhythmogenic Right Ventricular Cardiomyopathy Overview. 2005 Apr 18 [updated 2023 May 11]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024. Available from http://www.ncbi.nlm.nih.gov/books/NBK1131/ <a href="https://pubmed.ncbi.nlm.nih.gov/20301310" target="TheNewWin">Citation on PubMed</a></li> <li>Poloni G, De Bortoli M, Calore M, Rampazzo A, Lorenzon A. Arrhythmogenic right-ventricular cardiomyopathy: molecular genetics into clinical practice in the era of next generation sequencing. J Cardiovasc Med (Hagerstown). 2016 Jun;17(6):399-407. doi: 10.2459/JCM.0000000000000385. <a href="https://pubmed.ncbi.nlm.nih.gov/26990921" target="TheNewWin">Citation on PubMed</a></li> <li>Quarta G, Syrris P, Ashworth M, Jenkins S, Zuborne Alapi K, Morgan J, Muir A, Pantazis A, McKenna WJ, Elliott PM. Mutations in the Lamin A/C gene mimic arrhythmogenic right ventricular cardiomyopathy. Eur Heart J. 2012 May;33(9):1128-36. doi: 10.1093/eurheartj/ehr451. Epub 2011 Dec 23. <a href="https://pubmed.ncbi.nlm.nih.gov/22199124" target="TheNewWin">Citation on PubMed</a></li> <li>Taylor M, Graw S, Sinagra G, Barnes C, Slavov D, Brun F, Pinamonti B, Salcedo EE, Sauer W, Pyxaras S, Anderson B, Simon B, Bogomolovas J, Labeit S, Granzier H, Mestroni L. Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes. Circulation. 2011 Aug 23;124(8):876-85. doi: 10.1161/CIRCULATIONAHA.110.005405. Epub 2011 Aug 1. <a href="https://pubmed.ncbi.nlm.nih.gov/21810661" target="TheNewWin">Citation on PubMed</a> or <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167235/" target="TheNewWin">Free article on PubMed Central</a></li> <li>Te Riele AS, Hauer RN. Arrhythmogenic right ventricular dysplasia/cardiomyopathy: clinical challenges in a changing disease spectrum. Trends Cardiovasc Med. 2015 Apr;25(3):191-8. doi: 10.1016/j.tcm.2014.11.003. Epub 2014 Nov 15. <a href="https://pubmed.ncbi.nlm.nih.gov/25601034" target="TheNewWin">Citation on PubMed</a></li> <li>van der Zwaag PA, van Rijsingen IA, Asimaki A, Jongbloed JD, van Veldhuisen DJ, Wiesfeld AC, Cox MG, van Lochem LT, de Boer RA, Hofstra RM, Christiaans I, van Spaendonck-Zwarts KY, Lekanne dit Deprez RH, Judge DP, Calkins H, Suurmeijer AJ, Hauer RN, Saffitz JE, Wilde AA, van den Berg MP, van Tintelen JP. Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy. Eur J Heart Fail. 2012 Nov;14(11):1199-207. doi: 10.1093/eurjhf/hfs119. Epub 2012 Jul 20. <a href="https://pubmed.ncbi.nlm.nih.gov/22820313" target="TheNewWin">Citation on PubMed</a> or <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475434/" target="TheNewWin">Free article on PubMed Central</a></li> </ul> </div> </section> </div> </div> <div class="side"> <aside> <section><div class="side-section"> <div class="mp-img"> <a class="image-modal" id="14473_featured" href="https://medlineplus.gov/images/PX0002LE_PRESENTATION.jpeg" data-filepath="images/PX0002LE_PRESENTATION.jpeg" data-title="Normal heart anatomy" data-caption="" data-credit="U.S. National Library of Medicine" data-alt="A cross-section of various structures that make up the normal heart." data-sourceurl="https://www.nlm.nih.gov/"> <img class="scale-with-grid" src="https://medlineplus.gov/images/PX0002LE_PRESENTATION.jpeg" alt="" title="Normal heart anatomy"> <span class="view-img-full-size" title="Show image">Enlarge image</span> </a> </div> </div></section> <section><div class="side-section"> </div></section> <section><div class="side-section"> <div class="section-header"> <h2>Related Health Topics</h2> </div> <div class="section-body"> <ul class="relatedmp"> <li><a href="https://medlineplus.gov/cardiomyopathy.html">Cardiomyopathy</a></li> <li><a href="https://medlineplus.gov/geneticdisorders.html">Genetic Disorders</a></li> </ul> </div> </div></section> <section><div class="side-section"> <div class="section-header red"> <h2>MEDICAL ENCYCLOPEDIA</h2> </div> <div class="section-body" id="more_encyclopedia"> <ul class="relatedmp" style="list-style: none; padding: 0;"> <li><a href="https://medlineplus.gov/ency/article/001101.htm">Arrhythmias</a></li> <li><a href="https://medlineplus.gov/ency/article/001105.htm">Cardiomyopathy</a></li> <li><a href="https://medlineplus.gov/ency/article/002048.htm">Genetics</a></li> </ul> </div> </div></section> <section><div class="side-section"> <div class="section-header"> <h2>Understanding Genetics</h2> </div> <div class="section-body"> <ul class="relatedmp"> <li><a href="https://medlineplus.gov/genetics/understanding/consult/prognosis/">What is the prognosis of a genetic condition?</a></li> <li><a href="https://medlineplus.gov/genetics/understanding/mutationsanddisorders/mutationscausedisease/">How can gene variants affect health and development?</a></li> <li><a href="https://medlineplus.gov/genetics/understanding/inheritance/runsinfamily/">What does it mean if a disorder seems to run in my family?</a></li> <li><a href="https://medlineplus.gov/genetics/understanding/inheritance/inheritancepatterns/">What are the different ways a genetic condition can be inherited?</a></li> <li><a href="https://medlineplus.gov/genetics/understanding/consult/treatment/">How are genetic conditions treated or managed?</a></li> </ul> </div> </div></section> <section><div class="side-section"> <div class="section-header hide-offscreen"> <h2>Disclaimers</h2> </div> <div class="section-body no-header"> MedlinePlus links to health information from the National Institutes of Health and other federal government agencies. MedlinePlus also links to health information from non-government Web sites. See our <a href="https://medlineplus.gov/disclaimers.html">disclaimer</a> about external links and our <a href="https://medlineplus.gov/criteria.html">quality guidelines</a>. </div> </div></section> </aside> </div> <div class="bottom"> <section>  <p>The information on this site should not be used as a substitute for professional medical care or advice. 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Arrhythmogenic right ventricular cardiomyopathy: MedlinePlus Genetics