Targeted Protein Degradation (TPD) | Complete Solution

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background-position: top center; background-repeat: no-repeat; background-size: cover;"> <div> <div class="paragraph paragraph--type--h1-2-2-text-to-media paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:h1_2_2_text_to_media:field_indv_h1"> <div><h1>Targeted Protein Degradation</h1></div> </div> <div class="field_block:paragraph:h1_2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><p><strong>Targeted Protein Degradation</strong> (TPD) refers to the use of heterobifunctional small molecule "Degraders", such as PROTAC<sup>®</sup> Degraders, to achieve knockdown of target proteins within cells. These Degraders harness the ubiquitin-proteasome system to knockdown a protein of interest.</p></div> </div> <div class="field_block:paragraph:h1_2_2_text_to_media:field_call_to_action_global"> <a href="/search?search_type=products&keywords=targeted%20protein%20degradation" class="btn btn-primary" type="link"> Find Products for Targeted Protein Degradation </a> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:h1_2_2_text_to_media:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/targeted-protein-degradation-hero.png" alt="Targeted protein degradation" fetchpriority="high" > </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> </div> </header> </div> <div id="main" class="container-fluid container-wide"> <div class="row"> <div class="col-md-12"> <div> <div id="block-bio-techne-global-breadcrumbs" class="system_breadcrumb_block"> <nav role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> <a href="/research-areas">Research Areas</a> </li> <li> Targeted Protein Degradation </li> </ol> </nav> </div> </div> </div> </div> <main> <section class="section"> <div> <div id="block-bio-techne-global-content" class="system_main_block"> <article> <div> <div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>Transformative Tools for Induced Proximity and Targeted Protein Degradation</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--clickable-icons-container paragraph--view-mode--default"> <div class="container"> <div class="row"> <div class="col p-0 "> <h2></h2> </div> </div> <div class="row"> <div class="col "> </div> </div> <div class="row"> <div class="row"> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="#validation" > <div><article> <div><img src='https://resources.bio-techne.com/bio-techne-assets/images/icons/icon-target-goal-light-blue.png' alt='target'></div> </article> </div> <p><strong>Target Validation and Exploration </strong></p> </a> </div> </div> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="#degraderdesign" > <div><article> <div><img src='https://resources.bio-techne.com/bio-techne-assets/images/icons/icon-beaker_light_Blue.png' alt='beaker'></div> </article> </div> <p><strong>Degrader Design and Synthesis</strong></p> </a> </div> </div> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="#assaysfortpd" > <div><article> <div><img src='https://resources.bio-techne.com/bio-techne-assets/images/icons/icon-proteome-profiler-light-blue.png' alt='proteome profiler'></div> </article> </div> <p><strong>Assays for Targeted Protein Degradation </strong></p> </a> </div> </div> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="#proteasome" > <div><article> <div><img src='https://resources.bio-techne.com/bio-techne-assets/images/icons/icon-proteasome_light_blue.png' alt='proteasome'></div> </article> </div> <p><strong> E3 Ligases and UPS Biology</strong></p> </a> </div> </div> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="#custom" > <div><article> <div><img src='https://resources.bio-techne.com/bio-techne-assets/images/icons/tpd-icon-light.png' alt='Targeted protein degradation (TPD) icon representing a small molecule degrader bound to 2 proteins'></div> </article> </div> <p><strong>Custom Services for TPD </strong></p> </a> </div> </div> <div class="col-xl-2 col-lg-2 col-md-4 col-sm-6 col-6 mb-4"> <div class="paragraph paragraph--type--indvidual-clickable-icon paragraph--view-mode--default card p-3 text-center h-100 mb-0"> <a href="#resources" > <div><article> <div><img src='https://resources.bio-techne.com/bio-techne-assets/images/icons/icon-video-content_light_blue.png' alt='video content'></div> </article> </div> <p><strong>Resources for TPD</strong></p> </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--full-page-text-with-media mb-4 paragraph--view-mode--default"> <div><h2>What is Induced Proximity?</h2></div> <div><p>Induced Proximity is an approach that employs two ligands covalently joined by a linker, to bring two proteins, a target protein of interest (POI) and an effector, into close proximity. The induced proximity of POI and effector leads to an alteration to the POI, triggering a biological response. The POI can undergo a variety of changes including post-translational modification, degradation, autophagy, stabilization, dimerization, and cellular shuttling.</p><p>Targeted protein degradation utilizes heterobifunctional small molecule Degraders (e.g. PROTAC® molecules, SNIPERs etc) to bind the POI and recruits an E3 ligase to form a ternary complex. This initiates the ubiquitination of the POI and its subsequent destruction by the proteasome. There are a number of significant benefits to using this technology. Efficient and highly selective protein knock-down can be achieved both in vitro and in vivo. Degraders act catalytically by repeatedly engaging and directing the ubiquitination of the POI and can therefore be used at very low doses to achieve sustained knock-down. </p></div> </div> </div> <div> <div class="paragraph paragraph--type--full-page-text-with-media mb-4 paragraph--view-mode--default"> <div><p>Bio-Techne offers a full range of products and services for Targeted Protein Degradation research and development. Our tools will help you explore and validate your target of interest, develop new protein Degrader molecules and investigate their activity, as well as build your own assays for degradation. Our range includes: <a href="/research-areas/targeted-protein-degradation/protein-degraders">small molecule Protein Degraders</a> (e.g. PROTAC<sup>®</sup> degraders); <a href="/research-areas/targeted-protein-degradation/dtag-atag-degraders">aTAG, dTAG and BromoTag<sup>®</sup> Degraders</a> plus <a href="/research-areas/targeted-protein-degradation/degrader-building-blocks">Degrader Building Blocks</a>, <a href="/reagents/proteins/ubiquitin-proteasome-system">Ubiquitin-Proteasome System Proteins and Assays</a>, <a href="/instruments/simple-western">Assays for Protein Degradation</a> and <a href="/services/custom-targeted-protein-degradation-services">Custom Degrader Services</a>. </p></div> </div> </div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>Products and Services for Targeted Protein Degradation</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="validation"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--_-3-media-to-text paragraph--view-mode--default mb-4 p-3"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--25-75"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_indv_media"> <div> <a href="https://www.bio-techne.com/research-areas/targeted-protein-degradation/target-validation-exploration" title="Tools for Target Validation and Exploration" > <img src="https://resources.bio-techne.com/bio-techne-assets/images/icons/icon-target-goal-light-blue.png" alt="target" loading="lazy" > </a> </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_header_2_global"> <div><h2>Target Validation and Exploration</h2></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>Target Validation, the process of establishing that a potential molecular target is involved in a physiological function or disease process, is a key step in the development of new Degraders, as well as for drug discovery and biological research. Our TAG Degradation platform offers a differentiated method for target validation, using targeted protein degradation to reversibly knockdown a potential protein target and enable exploration of the downstream phenotype.</p></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_call_to_action_global"> <a href="/research-areas/targeted-protein-degradation/target-validation-exploration" class="btn btn-primary" type="link"> Tools for Target Validation and Exploration </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="degraderdesign"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--_-3-media-to-text paragraph--view-mode--default mb-4 p-3"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--25-75"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_indv_media"> <div> <a href="https://www.bio-techne.com/research-areas/targeted-protein-degradation/protac-degrader-design-synthesis" title="Products for Degrader Design and Synthesis" > <img src="https://resources.bio-techne.com/bio-techne-assets/images/icons/icon-beaker_light_Blue.png" alt="beaker" loading="lazy" > </a> </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_header_2_global"> <div><h2>Degrader Design and Synthesis</h2></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>Targeted protein degradation can be achieved using<a href="/research-areas/targeted-protein-degradation/protein-degraders"> small molecule Protein Degraders</a>, such as PROTAC molecules. Bio-Techne provides a toolbox of products and services to support your Degrader Design and Synthesis program and save you time and money, including our <a href="https://www.tocris.com/protac-panel-builder" target="_blank" title="Find out more at tocris.com">PROTAC Panel Builder</a> online tool; a large range of off-the-shelf Degrader Building Blocks; and tools for new E3 ligase ligand discovery.</p></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_call_to_action_global"> <a href="/research-areas/targeted-protein-degradation/protac-degrader-design-synthesis" class="btn btn-primary" type="link"> Products for Degrader Design and Synthesis </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="assaysfortpd"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--_-3-media-to-text paragraph--view-mode--default mb-4 p-3"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--25-75"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_indv_media"> <div> <a href="https://www.bio-techne.com/research-areas/targeted-protein-degradation/assays" title="Assay Products for Targeted Protein Degradation" > <img src="https://resources.bio-techne.com/bio-techne-assets/images/icons/icon-proteome-profiler-light-blue.png" alt="proteome profiler" loading="lazy" > </a> </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_header_2_global"> <div><h2>Assays for Targeted Protein Degradation</h2></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>Successful development of small molecule Protein Degraders for targeted protein degradation requires a variety of assays to characterize specific aspects of Degrader activity. The assay workflow should explore: target engagement and ternary complex formation induced by the Degrader; ubiquitination of the target protein; as well as target degradation and its downstream consequences. The use of multiple orthogonal assays will increase the chance of successful Degrader development. </p><p> </p></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_call_to_action_global"> <a href="/research-areas/targeted-protein-degradation/assays" class="btn btn-primary" type="link"> Assay Products for Targeted Protein Degradation </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="proteasome"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--_-3-media-to-text paragraph--view-mode--default mb-4 p-3"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--25-75"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_indv_media"> <div> <a href="https://www.bio-techne.com/reagents/proteins/ubiquitin-proteasome-system" title="E3 Ligase & UPS Biology Products" target="_self" > <img src="https://resources.bio-techne.com/bio-techne-assets/images/icons/icon-proteasome_light_blue.png" alt="proteasome" loading="lazy" > </a> </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_header_2_global"> <div><h2>E3 Ligase and Ubiquitin Proteasome System Biology</h2></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>Bio-Techne, through the R&D Systems<sup>TM </sup>brand, provides a wide range of products to help you explore and characterize ubiquitin biology. The rapidly expanding portfolio includes highly active <a href="/search?keywords=e3%20ligases&brand=rnd&category_attr=Proteins%20and%20Enzymes">E3 Ubiquitin Ligases</a>, including SKP2, VHL, Cereblon (CRBN) and DCAF proteins, as well as <a href="/search?keywords=e3%20ligases&brand=rnd">assay kits</a> and components, and <a href="/search?keywords=e3%20ligases&brand=rnd&category_attr=Primary%20Antibodies">antibodies</a>. We also provide <a href="/search?keywords=cullin&brand=rnd">Cullin-Rbx</a> complexes (including neddylated cullins) that can be coupled to your purified substrate-binding complexes to generate active ligases.</p></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_call_to_action_global"> <a href="/reagents/proteins/ubiquitin-proteasome-system" class="btn btn-primary" type="link"> E3 Ligase & UPS Biology Products </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="custom"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--_-3-media-to-text paragraph--view-mode--default mb-4 p-3"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--25-75"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_indv_media"> <div> <a href="https://www.bio-techne.com/services/custom-targeted-protein-degradation-services" title="Custom Targeted Protein Degradation Services " > <img src="https://resources.bio-techne.com/bio-techne-assets/images/icons/tpd-icon-light.png" alt="Targeted protein degradation (TPD) icon representing a small molecule degrader bound to 2 proteins" loading="lazy" > </a> </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_header_2_global"> <div><h2>Custom Services for Targeted Protein Degradation</h2></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>Bio-Techne offers a unique portfolio of custom services to support your PROTAC® discovery and development and target validation programs. Harness our expertise in custom chemistry to develop active degraders to knock down your target of choice or custom building block panels. We also offer custom E3 ligase development services enabling you to build your own assays to investigate ubiquitination.</p></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_call_to_action_global"> <a href="/services/custom-targeted-protein-degradation-services" class="btn btn-primary" type="link"> Custom Targeted Protein Degradation Services </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="resources"></a></p></div> </div> </div> <div> <section class="paragraph paragraph--type--full-width-banner-with-image mb-4 paragraph--view-mode--default paragraph-background-color--"> <div class="banner_background_image" data-bgimage="https://resources.bio-techne.com/bio-techne-assets/images/products/corafluor-banner-1110x350.jpg" style="background-repeat: no-repeat;"> <div> <div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><h2>Experience CoraFluor™ TR-FRET</h2><p>Redefining TR-FRET with brighter, robust, and versatile assay technology</p><p> </p></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_call_to_action_global"> <a href="/reagents/tr-fret-and-fp-assay-reagents" class="btn btn-primary" type="link"> View the Product Range </a> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> <div> <section class="paragraph paragraph--type--full-width-banner-with-image mb-4 paragraph--view-mode--default paragraph-background-color--dark"> <div class="banner_background_image" data-bgimage="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/recombinant_protein_banner_3.png" style="background-repeat: no-repeat;"> <div> <div> <div> <div class="paragraph paragraph--type--_-2-text-to-media mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><h2>BromoTag® Degrader for Target Exploration and Validation</h2><p>Exclusive to Bio-Techne</p><h3> </h3></div> </div> <div class="field_block:paragraph:2_2_text_to_media:field_call_to_action_global"> <a href="/t/bromotag" class="btn btn-primary" type="link"> Learn More </a> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <h2>Resources for Targeted Protein Degradation</h2> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/resources/literature/targeted-protein-degradation-research-guide" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/literature/bio-techne-tpd-brochure-thumb.jpg" alt="TPD Brochure FrontImg" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/resources/literature/targeted-protein-degradation-research-guide" > <h3 class="card_title_htag"> <div><h3>Brochure: Targeted Protein Degradation and Induced Proximity</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Our Targeted Protein Degradation and Induced Proximity Research Product Guide highlights the tools and services available from Bio-Techne to support your research including, Protein Degraders, Degrader Building Blocks, Custom Degrader Services, Proteins and Assays for protein degradation, and Tools for Induced Proximity Research.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/resources/literature/targeted-protein-degradation-research-guide" > Request Targeted Protein Degradation and Induced Proximity Guide </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/resources/webinars/5th-targeted-protein-degradation-symposium" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/webinars/4th-tpd-webinar-mockup-525x315.png" alt="4th Target Protein Degradation Symposium" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/resources/webinars/5th-targeted-protein-degradation-symposium" > <h3 class="card_title_htag"> <div><h3>5th Virtual Bio-Techne TPD and Induced Proximity Symposium</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Our 5th virtual symposium covered new developments from the leading scientists working in induced proximity research. Topics covered include: transcriptional kinases to activate apoptosis, degradation of BRD9 by a novel “targeted glue”, discovery of protein degraders and stabilizers, mechanisms of degrader-targeted protein ubiquitinability, and degraders of HIV-1 Nef for antiretroviral drug development.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/resources/webinars/5th-targeted-protein-degradation-symposium" > View Symposium on Demand </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/resources/literature/fully-automated-westerns-enable-cutting-edge-targeted-protein-degradation-research" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/literature/tpd-scientific-review-thumbnail.png" alt="Simple Western Hits the Bullseye of Targeted Protein Degradation" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="/resources/literature/fully-automated-westerns-enable-cutting-edge-targeted-protein-degradation-research" > <h3 class="card_title_htag"> <div><h3>Scientific Review: Simple Western Hits the Bullseye of TPD</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>This review highlights vital publications that represent Simple Western’s high-throughput screening of degrader activity with <a href="https://www.bio-techne.com/instruments/simple-western/looking-for-reliable-quantitative-results-simple-western">reproducible quantification</a>, flexible multiplex strategies, and fast time to results, from drug discovery of novel degraders through translation to the clinic.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/resources/literature/fully-automated-westerns-enable-cutting-edge-targeted-protein-degradation-research" > Download Scientific Review </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="https://www.sciencedirect.com/science/article/pii/S1471489221000539" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/about/ISSCR-graphics_resource.png" alt="Literature Icon" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="https://www.sciencedirect.com/science/article/pii/S1471489221000539" > <h3 class="card_title_htag"> <div><h3>Paper: Reviewing the Toolbox for Degrader Development in Oncology</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>This review discusses the toolbox of guidelines, reagents, and technologies available to support Degrader research and development in oncology. </p></div> </div> <div class="card-bottom-link"> <div> <a href="https://www.sciencedirect.com/science/article/pii/S1471489221000539" > Read the Review in Current Opinion in Pharmacology </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="https://www.tocris.com/resources/webinars-and-videos/what-is-targeted-protein-degradation" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/targeted-protein-degradation-frontimg.png" alt="PROTAC degrader molecule in complex with an E3 ligase and the target protein" loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="https://www.tocris.com/resources/webinars-and-videos/what-is-targeted-protein-degradation" > <h3 class="card_title_htag"> <div><h3>Video: What is Targeted Protein Degradation?</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>This short animation explains the fundamentals of Targeted Protein Degradation (TPD) using small molecule Protein Degraders or PROTACs, that harness the ubiquitin-proteasome system to selectively remove proteins from cell. </p></div> </div> <div class="card-bottom-link"> <div> <a href="https://www.tocris.com/resources/webinars-and-videos/what-is-targeted-protein-degradation" > Watch Video on Tocris.com </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="https://info.bio-techne.com/webinar-tackling-tpd-solutions.html" > <div class="card-img-top text-center mb-3" style="background-repeat: no-repeat; background-color: ; height:200px; width: 100%;"> <div class="teaser-valign-container" style=""> <div class="valign"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/icons/webinars-icon-light-blue.png" alt="Webinars icon " loading="lazy" > </div> </div> </div> </a> <a class="card_title_link" href="https://info.bio-techne.com/webinar-tackling-tpd-solutions.html" > <h3 class="card_title_htag"> <div><h3>Webinar: Workflow Solutions for PROTAC® Degrader Development</h3></div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Originally presented as a tech talk at Cell Bio Virtual 2020 by our Innovation Manager, Hannah Maple, PhD, this webinar presents how Bio-Techne can support your Degrader development program with our comprehensive workflow solution.</p></div> </div> <div class="card-bottom-link"> <div> <a href="https://info.bio-techne.com/webinar-tackling-tpd-solutions.html" > Watch Targeted Protein Degradation Webinar </a> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--background-information mb-4 paragraph--view-mode--default"> <div class="row"> <div class="col"> <div> <h3>Background Information </h3> </div> <div> <div id="accordion" class="paragraph paragraph--type--background-about paragraph--view-mode--default"> <div class="card-header rounded-top bg-white"> <a class="collapsed" data-toggle="collapse" href="#aboutPara-about-targeted-protein-degradation19" role="button" aria-expanded="false" aria-controls="aboutContents"> <h5>About Targeted Protein Degradation</h5> </a> </div> <div class="collapse" id="aboutPara-about-targeted-protein-degradation19" aria-expanded="false" aria-controls="aboutContents"> <div class="card-body"> <div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/degrader_building_blocks.png" alt="Schematic of Catalytic Mode of Action of Degrader Molecules" loading="lazy" > </div> </div> <div class="media-caption"> <div><strong>Schematic showing the catalytic mode of action of Degrader molecules.</strong></div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_header_2_global"> <div><h4>How do Degrader molecules work?</h4></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>Targeted Protein Degradation is a technique that uses heterobifunctional small molecule Degraders to bring about efficient and highly selective degradation of a target protein of interest. Targeted protein degradation enables investigation of the downstream consequences of protein knockdown and provides an easy-to-use method for target validation.</p><p>Bio-Techne provides <a href="/research-areas/targeted-protein-degradation/protein-degraders">small molecule Protein Degraders</a>, including PROTAC (PROteloysis TArgeting Chimera) molecules and <a href="/research-areas/targeted-protein-degradation/dtag-atag-degraders">TAG Degraders</a> (dTAG/aTAG/BromoTag). PROTAC molecules comprise a ligand that binds a target of interest joined by a linker to an E3 ligase ligand. A ternary complex is formed by the simultaneous binding of the Degrader to the target protein and the E3 ligase, which initiates ubiquitination of the target protein and its subsequent destruction by the proteasome. TAG Degraders work on a similar principle, but comprise an E3 ligase ligand linked to a compound that binds a fusion of a TAG degron with a target protein of interest. Degraders enable the knockdown of proteins for which there are no known ligands, enabling targeting of previously undruggable targets.</p><p>Bio-Techne supplies a range of other products and services to support Targeted Protein Degradation studies, including <a href="/research-areas/targeted-protein-degradation/degrader-building-blocks">Degrader Building Blocks</a> to enable you to create your own Degraders, as well as Ubiquitin-Proteasome System (UPS) Proteins and Assays, Assays for Protein Degradation, and Custom Degraders Services.</p></div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--full-page-text-with-media mb-4 paragraph--view-mode--default"> <div><h4>Why Use Degraders? </h4></div> <div><p>Small molecule Degraders offer several advantages over genetic manipulation for target protein knockdown:</p><ul><li>Degraders are cell-permeable, are suitable for use <em>in vivo</em> and <em>in vitro,</em> and can be applied directly to cells with no need for transfection or expression vectors.</li><li>They are applicable to multiple cell lines with no requirement that cells are easily transfectable</li><li>The duration of effect is adjustable and reversible on compound washout</li><li>They have a catalytic mode of action repeatedly engaging and directing ubiquitination of target molecules, allowing use at sub-stoichiometric concentrations.</li></ul></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><em>PROTAC</em><em><sup>®</sup></em><em> is a registered trademark of Arvinas Operations, Inc., and is used under license</em>.</p> <p><em>BromoTag</em><em><sup>®</sup> is a registered trademark of the University of Dundee and is used under license.</em></p></div> </div> </div> </div> </div> </article> </div> </div> </section> </main> </div> <div id="brandsbar-footer" class="bg-bt-primary"> <div 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