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Using deep mutational scanning, Bernadeta Dadonaite, Jesse Bloom and colleagues reveal how the >10,000 different possible amino-acid mutations in hemagglutinin affect cell entry, receptor preference, protein stability and neutralization by antibodies.</p> </div> <p class="credit">Image credit: pbio.3002916</p> </div> </div> <div id="billboard"> <h3>PLOS Biologue</h3> <h4>Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.</h4><a href="https://biologue.plos.org/">PLOS BIOLOGUE</a> </div> </div> <div class="row one"> <article class="block medium image" id="cellcat-1-1"> <div class="block-content"> <p class="date">11/14/2024</p> <p class="category">Short Reports</p> <h2 class="title"><a alt="Social learning by new-comers" href="/plosbiology/article?id=10.1371/journal.pbio.3002699">Social learning by new-comers</a></h2> <div class="blurb"> <p>Theory predicts that strategic flexibility in using social information can help individuals make adaptive decisions. 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Yunlu Zhu, David Schoppik and co-workers describe a sensorimotor circuit that transforms gravitational signals into persistent heading for vertical navigation, showing how vestibular inputs allow animals to move effectively through their environment.</p> </div> </div> <p class="credits">Image credit: Yunlu Zhu</p><a class="block-image" alt="Which way is up?" href="/plosbiology/article?id=10.1371/journal.pbio.3002902"><img alt="Which way is up?" data-file-extension="jpg" src="/plosbiology/indirect/2bda6bc49cabe62e29d114b58208acbd2540811073f0dba56604d2bee8f60a84"></a> </article> <article class="block medium image" id="cellcat-1-3"> <div class="block-content"> <p class="date">11/12/2024</p> <p class="category">Research Article</p> <h2 class="title"><a alt="Early role for 尾-catenin in sea urchin embryogenesis" href="/plosbiology/article?id=10.1371/journal.pbio.3002880">Early role for 尾-catenin in sea urchin embryogenesis</a></h2> <div class="blurb"> <p>Beta-catenin plays essential roles during the early embryogenesis of many animals, but these roles have been established mainly at the time of fertilization. Guy Lhomond, Michael Schubert and Jenifer Croce use an inducible knockdown system to determine the spatiotemporal roles played by nuclear b-catenin during early embryogenesis of sea urchin.</p> </div> </div> <p class="credits">Image credit: pbio.3002880</p><a class="block-image" alt="Early role for 尾-catenin in sea urchin embryogenesis" href="/plosbiology/article?id=10.1371/journal.pbio.3002880"><img alt="Early role for 尾-catenin in sea urchin embryogenesis" data-file-extension="jpg" src="/plosbiology/indirect/5809aa4dd8a90020f636ae02ec14819bbf53f9201c50a7be83d9430726aa7560"></a> </article> </div> <div class="row three"> <div class="column left"> <article class="block large image" id="cellcat2-1"> <div class="block-content"> <p class="date">11/12/2024</p> <p class="category">Research Article</p> <h2 class="title"><a alt="How coral larvae keep symbionts sweet under stress" href="/plosbiology/article?id=10.1371/journal.pbio.3002875">How coral larvae keep symbionts sweet under stress</a></h2> <div class="blurb"> <p>Rising sea surface temperatures threaten coral-algal symbiosis, impacting reef ecosystems. 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David Richter Tim Kietzmann and Floris de Lange show that prediction errors are computed at higher cortical levels and the resulting surprise signal is broadcast to earlier areas.</p> </div> </div><a class="block-image" alt="What happens next?" href="/plosbiology/article?id=10.1371/journal.pbio.3002829"><img alt="What happens next?" data-file-extension="jpg" src="/plosbiology/indirect/2b7ee6d868e6715a554ba1069ccdbd8f6dd1fdca45c22fe7d2e97acd5cde7b31"></a> <p class="credits">Image credit: pbio.3002829</p> </article> <div class="row-small-blocks"> <article class="block small image" id="cellcat3-1"> <div class="block-content"> <p class="date">11/05/2024</p> <p class="category">Perspective</p> <h2 class="title"><a alt="Harnessing plant biosynthesis" href="/plosbiology/article?id=10.1371/journal.pbio.3002886">Harnessing plant biosynthesis</a></h2> <div class="blurb"> <p>Genomics-based predictions indicate that plants are able to make a vast array of undiscovered chemistry. This Perspective argues that we now have the potential to harness this capability at unprecedented scale for the discovery of new drugs.</p> </div> </div><a class="block-image" alt="Harnessing plant biosynthesis" href="/plosbiology/article?id=10.1371/journal.pbio.3002886"><img alt="Harnessing plant biosynthesis" data-file-extension="jpg" src="/plosbiology/indirect/8d4438254eae6b478d853d30fd200ad0662fdd0ab6856442be7cd942fa083e90"></a> <p class="credits">Image credit: pbio.3002886</p> </article> <article class="block small image" id="cellcat3-2"> <div class="block-content"> <p class="date">10/30/2024</p> <p class="category">Editorial</p> <h2 class="title"><a alt="The promises and challenges of neurotechnology" href="/plosbiology/article?id=10.1371/journal.pbio.3002903">The promises and challenges of neurotechnology</a></h2> <div class="blurb"> <p>Simon Hanslmayr introduces a <a href="https://collections.plos.org/collection/neurotechnology-human-health-cognition/">Collection</a> which explores the present and possible futures of neurotechnology, as well as the scientific, technological and ethical challenges they face.</p> <p><br></p> </div> </div><a class="block-image" alt="The promises and challenges of neurotechnology" href="/plosbiology/article?id=10.1371/journal.pbio.3002903"><img alt="The promises and challenges of neurotechnology" data-file-extension="jpg" src="/plosbiology/indirect/a94016459ab21d021d0816dba70240923418da6a19e0abbd107f72cbec0a5d2d"></a> <p class="credits">Image credit: Pixabay user Gerd Altmann</p> </article> <article class="block small image" id="cellcat3-3"> <div class="block-content"> <p class="date">10/29/2024</p> <p class="category">Essay</p> <h2 class="title"><a alt="The future of transcranial ultrasound" href="/plosbiology/article?id=10.1371/journal.pbio.3002884">The future of transcranial ultrasound</a></h2> <div class="blurb"> <p>TUS is a promising non-invasive solution to interface with specific brain regions with high precision. This Essay explores the challenges and proposes a roadmap for the evolution of TUS from a research tool to a clinically validated therapeutic.</p> </div> </div><a class="block-image" alt="The future of transcranial ultrasound" href="/plosbiology/article?id=10.1371/journal.pbio.3002884"><img alt="The future of transcranial ultrasound" data-file-extension="jpg" src="/plosbiology/indirect/706f8687700985636fb8510accb1f156e31df148fe4dbb1b03dc62979a045a18"></a> <p class="credits">Image credit: pbio.3002884</p> </article> <article class="block small image" id="cellcat3-4"> <div class="block-content"> <p class="date">10/29/2024</p> <p class="category">Perspective</p> <h2 class="title"><a alt="Closing the sensory feedback loop" href="/plosbiology/article?id=10.1371/journal.pbio.3002866">Closing the sensory feedback loop</a></h2> <div class="blurb"> <p>This Perspective discusses how closing the sensory feedback loop in brain implants and nerve electrodes for stimulation may improve rehabilitation and assistive systems for patients.</p> </div> </div><a class="block-image" alt="Closing the sensory feedback loop" href="/plosbiology/article?id=10.1371/journal.pbio.3002866"><img alt="Closing the sensory feedback loop" data-file-extension="jpg" src="/plosbiology/indirect/9e33b6e64d05810851c31de30a4c9b8f9ae5316395174f7247751910f4d02c96"></a> <p class="credits">Image credit: pbio.3002866</p> </article> </div> <div class="row-small-blocks"> <article class="carousel-wrap jcarousel-wrapper small" id="carousel-1"> <div class="block-header"> Collections </div> <div class="jcarousel carousel"> <ul> <li> <h3><a href="https://collections.plos.org/collection/neurotechnology-human-health-cognition/" alt="The promises and challenges of neurotechnology">The promises and challenges of neurotechnology</a></h3> <p></p> <p>Neurotechnology offers unprecedented opportunities to treat neural disorders, restore brain function and enhance cognitive abilities. This collection explores the present and possible futures of neurotechnology to improve human health and cognition.</p> <p></p> <p></p> <p></p></li> <li> <h3><a href="https://collections.plos.org/collection/conservation-and-biodiversity/" alt="Decision making for conservation and biodiversity">Decision making for conservation and biodiversity</a></h3> <p></p> <p>Translating conservation and biodiversity research from the field into the real world is a complex problem. This collection discusses issues around economics, policy, and how to do research that answers questions that decision makers have.</p> <p></p></li> <li> <h3><a href="https://collections.plos.org/collection/symbiosis-across-the-tree-of-life/" alt="Symbiosis across the tree of life">Symbiosis across the tree of life</a></h3> <p></p> <p>Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.</p> <p></p> <p></p></li> <li> <h3><a href="https://collections.plos.org/collection/plos-biology-20th-anniversary/" alt="PLOS Biology 20th Anniversary">PLOS Biology 20th Anniversary<br></a></h3> <p></p> <p>PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.</p> <p>.</p> <p><br></p> <p></p></li> <li> <h3><a href="https://collections.plos.org/collection/engineering-plants-for-a-changing-climate/" alt="Engineering plants for a changing climate">Engineering plants for a changing climate</a></h3> <p></p> <p>This collection explores engineering strategies to help us adapt plants to a changing climate, including breeding techniques, genome engineering, synthetic biology and microbiome engineering.<br></p> <p></p></li> </ul> </div> <div class="carousel-control"> <a class="jcarousel-prev" href="#"></a> <div class="numbers"> <span class="number" data-js="carousel-current-item"></span> <span>  of  </span> <span class="number" data-js="carousel-total-index"></span> </div><a class="jcarousel-next" href="#"></a> </div> </article> <article class="carousel-wrap jcarousel-wrapper small" id="carousel-2"> <div class="block-header"> Meet our staff at conferences </div> <div class="jcarousel carousel"> <ul> <li> <h3><a href="https://www.britishecologicalsociety.org/events/bes-annual-meeting-2024/" alt="British Ecology Society meeting 2024">British Ecology Society meeting 2024</a></h3> <p><br></p> <p>December 10 - 13</p> <p><br></p> <p>Meet Senior Editor Roli Roberts (rroberts@plos.org)<br></p> <p></p></li> <li> <h3><a href="https://www.ascb.org/cellbio2024/" alt="Cell Bio 24">Cell Bio 24<br></a></h3> <p><br></p> <p>December 14 - 18</p> <p><br></p> <p>Meet Senior Editor Ines Alvarez-Garcia (ialvarez-garcia@plos.org)<br></p> <p></p></li> <li> <h3><a href="https://www.uniklinik-freiburg.de/zoonotic-viruses-and-beyond.html" alt="Molecular Determinants of Zoonotic Viruses and Beyond">Molecular Determinants of Zoonotic Viruses and Beyond</a></h3> <p><br></p> <p>February 27 - March 1</p> <p><br></p> <p>Meet Associate Editor Melissa Vazquez Hernandez (mvazquezhernandez@plos.org)<br></p> <p></p></li> <li> <h3><a href="https://hugo-hgm2025.org/" alt="Human Genome Meeting 2025">Human Genome Meeting 2025</a></h3> <p><br></p> <p>March 12 - 14</p> <p><br></p> <p>Meet Editor in Chief Nonia Pariente (npariente@plos.org)<br></p> <p></p></li> </ul> </div> <div class="carousel-control"> <a class="jcarousel-prev" href="#"></a> <div class="numbers"> <span class="number" data-js="carousel-current-item"></span> <span>  of  </span> <span class="number" data-js="carousel-total-index"></span> </div><a class="jcarousel-next" href="#"></a> </div> </article> </div> </div> <div class="column right"> <div id="external-content-top"> <div id="blogs" data-host-name="https://blogs.plos.org/" data-blog-title="PLOS Biologue" data-blog-url="https://blogs.plos.org/biologue" data-feed-url="https://blogs.plos.org/biologue/?feed=json" data-post-count="4"> </div> <div id="submission-links"> <h3>Publish with PLOS</h3> <p><a href="/plosbiology/s/submit-now" id="submissionManu">Submit Your Manuscript</a></p> </div> <div id="social-links"> <h3>Connect with Us</h3> <ul class="social-media"> <li id="social-link-email"><a href="/plosbiology/s/contact" class="social" title="Contact Us"> <span class="icon-email" icon-hidden="true"></span> <span class="icon-text">Contact Us</span> </a></li> <li id="social-link-RSS"><a href="/plosbiology/feed/atom" class="social" title="RSS"> <span class="icon-rss" icon-hidden="true"></span> <span class="icon-text">RSS</span> </a></li> <li id="social-link-twitter"><a href="https://twitter.com/plosbiology" class="social" title="PLOS Biology on Twitter" target="_blank"> <span class="icon-twitter" icon-hidden="true"></span> <span class="icon-text">PLOS Biology on Twitter</span> </a></li> <li id="social-link-facebook"><a href="https://www.facebook.com/plos.org" class="social" title="PLOS on Facebook" target="_blank"> <span class="icon-facebook" icon-hidden="true"></span> <span class="icon-text">PLOS on Facebook</span> </a></li> <li id="social-link-blogs"><a href="https://blogs.plos.org/" class="social-blogs" title="PLOS Blogs">PLOS Blogs</a></li> </ul> </div> </div> <div id="external-content-bottom"> <div id="twitter"> <section id="twitter1" class="twitter"> <a class="twitter-timeline" data-height="696" href="https://twitter.com/plosbiology?ref_src=twsrc%5Etfw">Tweets by @plosbiology</a> <script> (function() { function loadTwitter() { if(window.plosCookieConsent) { if(window.plosCookieConsent.hasConsented('functionality')) { $.getScript("https://platform.twitter.com/widgets.js"); 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