CINXE.COM

<!DOCTYPE html> <html class="client-nojs vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-disabled skin-theme-clientpref-day vector-toc-available" lang="it" dir="ltr"> <head> <meta charset="UTF-8"> <title>DNA polimerasi (DNA-dipendente) - Wikipedia</title> <script>(function(){var className="client-js vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-disabled skin-theme-clientpref-day vector-toc-available";var cookie=document.cookie.match(/(?:^|; )itwikimwclientpreferences=([^;]+)/);if(cookie){cookie[1].split('%2C').forEach(function(pref){className=className.replace(new RegExp('(^| )'+pref.replace(/-clientpref-\w+$|[^\w-]+/g,'')+'-clientpref-\\w+( |$)'),'$1'+pref+'$2');});}document.documentElement.className=className;}());RLCONF={"wgBreakFrames":false,"wgSeparatorTransformTable":[",\t."," \t,"],"wgDigitTransformTable":["",""], "wgDefaultDateFormat":"dmy","wgMonthNames":["","gennaio","febbraio","marzo","aprile","maggio","giugno","luglio","agosto","settembre","ottobre","novembre","dicembre"],"wgRequestId":"72779b40-f2b3-4267-923d-046de60198a3","wgCanonicalNamespace":"","wgCanonicalSpecialPageName":false,"wgNamespaceNumber":0,"wgPageName":"DNA_polimerasi_(DNA-dipendente)","wgTitle":"DNA polimerasi (DNA-dipendente)","wgCurRevisionId":141865276,"wgRevisionId":141865276,"wgArticleId":107163,"wgIsArticle":true,"wgIsRedirect":false,"wgAction":"view","wgUserName":null,"wgUserGroups":["*"],"wgCategories":["P591 letta da Wikidata","EC 2.7.7"],"wgPageViewLanguage":"it","wgPageContentLanguage":"it","wgPageContentModel":"wikitext","wgRelevantPageName":"DNA_polimerasi_(DNA-dipendente)","wgRelevantArticleId":107163,"wgIsProbablyEditable":true,"wgRelevantPageIsProbablyEditable":true,"wgRestrictionEdit":[],"wgRestrictionMove":[],"wgRedirectedFrom":"DNA_polimerasi","wgNoticeProject":"wikipedia","wgCiteReferencePreviewsActive": false,"wgMediaViewerOnClick":true,"wgMediaViewerEnabledByDefault":true,"wgPopupsFlags":0,"wgVisualEditor":{"pageLanguageCode":"it","pageLanguageDir":"ltr","pageVariantFallbacks":"it"},"wgMFDisplayWikibaseDescriptions":{"search":true,"watchlist":true,"tagline":true,"nearby":true},"wgWMESchemaEditAttemptStepOversample":false,"wgWMEPageLength":8000,"wgInternalRedirectTargetUrl":"/wiki/DNA_polimerasi_(DNA-dipendente)","wgRelatedArticlesCompat":[],"wgCentralAuthMobileDomain":false,"wgEditSubmitButtonLabelPublish":true,"wgULSPosition":"interlanguage","wgULSisCompactLinksEnabled":false,"wgVector2022LanguageInHeader":true,"wgULSisLanguageSelectorEmpty":false,"wgWikibaseItemId":"Q206286","wgCheckUserClientHintsHeadersJsApi":["brands","architecture","bitness","fullVersionList","mobile","model","platform","platformVersion"],"GEHomepageSuggestedEditsEnableTopics":true,"wgGETopicsMatchModeEnabled":false,"wgGEStructuredTaskRejectionReasonTextInputEnabled":false,"wgGELevelingUpEnabledForUser":false}; RLSTATE={"ext.gadget.coloriDarkMode-default":"ready","ext.globalCssJs.user.styles":"ready","site.styles":"ready","user.styles":"ready","ext.globalCssJs.user":"ready","user":"ready","user.options":"loading","skins.vector.search.codex.styles":"ready","skins.vector.styles":"ready","skins.vector.icons":"ready","ext.wikimediamessages.styles":"ready","ext.visualEditor.desktopArticleTarget.noscript":"ready","ext.uls.interlanguage":"ready","wikibase.client.init":"ready","ext.wikimediaBadges":"ready"};RLPAGEMODULES=["mediawiki.action.view.redirect","site","mediawiki.page.ready","mediawiki.toc","skins.vector.js","ext.centralNotice.geoIP","ext.centralNotice.startUp","ext.gadget.MainPageWikiList","ext.gadget.stru-commonsupload","ext.gadget.HiddenCat","ext.gadget.ReferenceTooltips","ext.gadget.TitoloErrato","ext.gadget.NewSection","ext.gadget.RichiediRevisioneBozza","ext.urlShortener.toolbar","ext.centralauth.centralautologin","mmv.bootstrap","ext.popups", "ext.visualEditor.desktopArticleTarget.init","ext.visualEditor.targetLoader","ext.echo.centralauth","ext.eventLogging","ext.wikimediaEvents","ext.navigationTiming","ext.uls.interface","ext.cx.eventlogging.campaigns","ext.cx.uls.quick.actions","wikibase.client.vector-2022","ext.checkUser.clientHints","ext.growthExperiments.SuggestedEditSession","wikibase.sidebar.tracking"];</script> <script>(RLQ=window.RLQ||[]).push(function(){mw.loader.impl(function(){return["user.options@12s5i",function($,jQuery,require,module){mw.user.tokens.set({"patrolToken":"+\\","watchToken":"+\\","csrfToken":"+\\"}); }];});});</script> <link rel="stylesheet" href="/w/load.php?lang=it&modules=ext.uls.interlanguage%7Cext.visualEditor.desktopArticleTarget.noscript%7Cext.wikimediaBadges%7Cext.wikimediamessages.styles%7Cskins.vector.icons%2Cstyles%7Cskins.vector.search.codex.styles%7Cwikibase.client.init&only=styles&skin=vector-2022"> <script async="" src="/w/load.php?lang=it&modules=startup&only=scripts&raw=1&skin=vector-2022"></script> <meta name="ResourceLoaderDynamicStyles" content=""> <link rel="stylesheet" href="/w/load.php?lang=it&modules=ext.gadget.coloriDarkMode-default&only=styles&skin=vector-2022"> <link rel="stylesheet" href="/w/load.php?lang=it&modules=site.styles&only=styles&skin=vector-2022"> <meta name="generator" content="MediaWiki 1.44.0-wmf.5"> <meta name="referrer" content="origin"> <meta name="referrer" content="origin-when-cross-origin"> <meta name="robots" content="max-image-preview:standard"> <meta name="format-detection" content="telephone=no"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/9/90/DNA_polymerase.png"> <meta property="og:image:width" content="1200"> <meta property="og:image:height" content="1193"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/9/90/DNA_polymerase.png"> <meta property="og:image:width" content="800"> <meta property="og:image:height" content="796"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/9/90/DNA_polymerase.png/640px-DNA_polymerase.png"> <meta property="og:image:width" content="640"> <meta property="og:image:height" content="637"> <meta name="viewport" content="width=1120"> <meta property="og:title" content="DNA polimerasi (DNA-dipendente) - Wikipedia"> <meta property="og:type" content="website"> <link rel="preconnect" href="//upload.wikimedia.org"> <link rel="alternate" media="only screen and (max-width: 640px)" href="//it.m.wikipedia.org/wiki/DNA_polimerasi_(DNA-dipendente)"> <link rel="alternate" type="application/x-wiki" title="Modifica" href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=edit"> <link rel="apple-touch-icon" href="/static/apple-touch/wikipedia.png"> <link rel="icon" href="/static/favicon/wikipedia.ico"> <link rel="search" type="application/opensearchdescription+xml" href="/w/rest.php/v1/search" title="Wikipedia (it)"> <link rel="EditURI" type="application/rsd+xml" href="//it.wikipedia.org/w/api.php?action=rsd"> <link rel="canonical" href="https://it.wikipedia.org/wiki/DNA_polimerasi_(DNA-dipendente)"> <link rel="license" href="https://creativecommons.org/licenses/by-sa/4.0/deed.it"> <link rel="alternate" type="application/atom+xml" title="Feed Atom di Wikipedia" href="/w/index.php?title=Speciale:UltimeModifiche&feed=atom"> <link rel="dns-prefetch" href="//meta.wikimedia.org" /> <link rel="dns-prefetch" href="//login.wikimedia.org"> </head> <body class="skin--responsive skin-vector skin-vector-search-vue mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject mw-editable page-DNA_polimerasi_DNA-dipendente rootpage-DNA_polimerasi_DNA-dipendente skin-vector-2022 action-view"><a class="mw-jump-link" href="#bodyContent">Vai al contenuto</a> <div class="vector-header-container"> <header class="vector-header mw-header"> <div class="vector-header-start"> <nav class="vector-main-menu-landmark" aria-label="Sito"> <div id="vector-main-menu-dropdown" class="vector-dropdown vector-main-menu-dropdown vector-button-flush-left vector-button-flush-right" > <input type="checkbox" id="vector-main-menu-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-main-menu-dropdown" class="vector-dropdown-checkbox " aria-label="Menu principale" > <label id="vector-main-menu-dropdown-label" for="vector-main-menu-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-menu mw-ui-icon-wikimedia-menu"></span> <span class="vector-dropdown-label-text">Menu principale</span> </label> <div class="vector-dropdown-content"> <div id="vector-main-menu-unpinned-container" class="vector-unpinned-container"> <div id="vector-main-menu" class="vector-main-menu vector-pinnable-element"> <div class="vector-pinnable-header vector-main-menu-pinnable-header vector-pinnable-header-unpinned" data-feature-name="main-menu-pinned" data-pinnable-element-id="vector-main-menu" data-pinned-container-id="vector-main-menu-pinned-container" data-unpinned-container-id="vector-main-menu-unpinned-container" > <div class="vector-pinnable-header-label">Menu principale</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-main-menu.pin">sposta nella barra laterale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-main-menu.unpin">nascondi</button> </div> <div id="p-navigation" class="vector-menu mw-portlet mw-portlet-navigation" > <div class="vector-menu-heading"> Navigazione </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-mainpage-description" class="mw-list-item"><a href="/wiki/Pagina_principale" title="Visita la pagina principale [z]" accesskey="z"><span>Pagina principale</span></a></li><li id="n-recentchanges" class="mw-list-item"><a href="/wiki/Speciale:UltimeModifiche" title="Elenco delle ultime modifiche del sito [r]" accesskey="r"><span>Ultime modifiche</span></a></li><li id="n-randompage" class="mw-list-item"><a href="/wiki/Speciale:PaginaCasuale" title="Mostra una pagina a caso [x]" accesskey="x"><span>Una voce a caso</span></a></li><li id="n-nearby-pages-title" class="mw-list-item"><a href="/wiki/Speciale:NelleVicinanze"><span>Nelle vicinanze</span></a></li><li id="n-vetrina" class="mw-list-item"><a href="/wiki/Wikipedia:Vetrina"><span>Vetrina</span></a></li><li id="n-help" class="mw-list-item"><a href="/wiki/Aiuto:Aiuto" title="Pagine di aiuto"><span>Aiuto</span></a></li><li id="n-Sportello-informazioni" class="mw-list-item"><a href="/wiki/Aiuto:Sportello_informazioni"><span>Sportello informazioni</span></a></li> </ul> </div> </div> <div id="p-Comunità" class="vector-menu mw-portlet mw-portlet-Comunità" > <div class="vector-menu-heading"> Comunità </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-portal" class="mw-list-item"><a href="/wiki/Portale:Comunit%C3%A0" title="Descrizione del progetto, cosa puoi fare, dove trovare le cose"><span>Portale Comunità</span></a></li><li id="n-villagepump" class="mw-list-item"><a href="/wiki/Wikipedia:Bar"><span>Bar</span></a></li><li id="n-wikipediano" class="mw-list-item"><a href="/wiki/Wikipedia:Wikipediano"><span>Il Wikipediano</span></a></li><li id="n-contactpage" class="mw-list-item"><a href="/wiki/Wikipedia:Contatti"><span>Contatti</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> <a href="/wiki/Pagina_principale" class="mw-logo"> <img class="mw-logo-icon" src="/static/images/icons/wikipedia.png" alt="" aria-hidden="true" height="50" width="50"> <span class="mw-logo-container skin-invert"> <img class="mw-logo-wordmark" alt="Wikipedia" src="/static/images/mobile/copyright/wikipedia-wordmark-en.svg" style="width: 7.5em; height: 1.125em;"> <img class="mw-logo-tagline" alt="L'enciclopedia libera" src="/static/images/mobile/copyright/wikipedia-tagline-it.svg" width="120" height="13" style="width: 7.5em; height: 0.8125em;"> </span> </a> </div> <div class="vector-header-end"> <div id="p-search" role="search" class="vector-search-box-vue vector-search-box-collapses vector-search-box-show-thumbnail vector-search-box-auto-expand-width vector-search-box"> <a href="/wiki/Speciale:Ricerca" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only search-toggle" title="Cerca in Wikipedia [f]" accesskey="f"><span class="vector-icon mw-ui-icon-search mw-ui-icon-wikimedia-search"></span> <span>Ricerca</span> </a> <div class="vector-typeahead-search-container"> <div class="cdx-typeahead-search cdx-typeahead-search--show-thumbnail cdx-typeahead-search--auto-expand-width"> <form action="/w/index.php" id="searchform" class="cdx-search-input cdx-search-input--has-end-button"> <div id="simpleSearch" class="cdx-search-input__input-wrapper" data-search-loc="header-moved"> <div class="cdx-text-input cdx-text-input--has-start-icon"> <input class="cdx-text-input__input" type="search" name="search" placeholder="Cerca in Wikipedia" aria-label="Cerca in Wikipedia" autocapitalize="sentences" title="Cerca in Wikipedia [f]" accesskey="f" id="searchInput" > <span class="cdx-text-input__icon cdx-text-input__start-icon"></span> </div> <input type="hidden" name="title" value="Speciale:Ricerca"> </div> <button class="cdx-button cdx-search-input__end-button">Ricerca</button> </form> </div> </div> </div> <nav class="vector-user-links vector-user-links-wide" aria-label="Strumenti personali"> <div class="vector-user-links-main"> <div id="p-vector-user-menu-preferences" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-userpage" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <nav class="vector-appearance-landmark" aria-label="Aspetto"> <div id="vector-appearance-dropdown" class="vector-dropdown " title="Modifica la dimensione, la larghezza e il colore del testo" > <input type="checkbox" id="vector-appearance-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-appearance-dropdown" class="vector-dropdown-checkbox " aria-label="Aspetto" > <label id="vector-appearance-dropdown-label" for="vector-appearance-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-appearance mw-ui-icon-wikimedia-appearance"></span> <span class="vector-dropdown-label-text">Aspetto</span> </label> <div class="vector-dropdown-content"> <div id="vector-appearance-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_it.wikipedia.org&uselang=it" class=""><span>Fai una donazione</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Speciale:CreaUtenza&returnto=DNA+polimerasi+%28DNA-dipendente%29" title="Si consiglia di registrarsi e di effettuare l'accesso, anche se non è obbligatorio" class=""><span>registrati</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Speciale:Entra&returnto=DNA+polimerasi+%28DNA-dipendente%29" title="Si consiglia di effettuare l'accesso, anche se non è obbligatorio [o]" accesskey="o" class=""><span>entra</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="Altre opzioni" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="Strumenti personali" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-ellipsis mw-ui-icon-wikimedia-ellipsis"></span> <span class="vector-dropdown-label-text">Strumenti personali</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="Menu utente" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_it.wikipedia.org&uselang=it"><span>Fai una donazione</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Speciale:CreaUtenza&returnto=DNA+polimerasi+%28DNA-dipendente%29" title="Si consiglia di registrarsi e di effettuare l'accesso, anche se non è obbligatorio"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>registrati</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Speciale:Entra&returnto=DNA+polimerasi+%28DNA-dipendente%29" title="Si consiglia di effettuare l'accesso, anche se non è obbligatorio [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>entra</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Pagine per utenti anonimi <a href="/wiki/Aiuto:Benvenuto" aria-label="Ulteriori informazioni sulla contribuzione"><span>ulteriori informazioni</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Speciale:MieiContributi" title="Un elenco delle modifiche fatte da questo indirizzo IP [y]" accesskey="y"><span>contributi</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Speciale:MieDiscussioni" title="Discussioni sulle modifiche fatte da questo indirizzo IP [n]" accesskey="n"><span>discussioni</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Sito"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Indice" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Indice</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">sposta nella barra laterale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">nascondi</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Inizio</div> </a> </li> <li id="toc-Attività_esonucleasica" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Attività_esonucleasica"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Attività esonucleasica</span> </div> </a> <ul id="toc-Attività_esonucleasica-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-DNA_polimerasi_procariotiche" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#DNA_polimerasi_procariotiche"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>DNA polimerasi procariotiche</span> </div> </a> <button aria-controls="toc-DNA_polimerasi_procariotiche-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Attiva/disattiva la sottosezione DNA polimerasi procariotiche</span> </button> <ul id="toc-DNA_polimerasi_procariotiche-sublist" class="vector-toc-list"> <li id="toc-DNA_polimerasi_V" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#DNA_polimerasi_V"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>DNA polimerasi V</span> </div> </a> <ul id="toc-DNA_polimerasi_V-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-DNA_polimerasi_eucariotiche" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#DNA_polimerasi_eucariotiche"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>DNA polimerasi eucariotiche</span> </div> </a> <button aria-controls="toc-DNA_polimerasi_eucariotiche-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Attiva/disattiva la sottosezione DNA polimerasi eucariotiche</span> </button> <ul id="toc-DNA_polimerasi_eucariotiche-sublist" class="vector-toc-list"> <li id="toc-DNA_polimerasi_γ" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#DNA_polimerasi_γ"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>DNA polimerasi γ</span> </div> </a> <ul id="toc-DNA_polimerasi_γ-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-DNA_polimerasi_δ" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#DNA_polimerasi_δ"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span>DNA polimerasi δ</span> </div> </a> <ul id="toc-DNA_polimerasi_δ-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-DNA_polimerasi_ε" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#DNA_polimerasi_ε"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.3</span> <span>DNA polimerasi ε</span> </div> </a> <ul id="toc-DNA_polimerasi_ε-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Farmacologia" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Farmacologia"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Farmacologia</span> </div> </a> <ul id="toc-Farmacologia-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Curiosità" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Curiosità"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Curiosità</span> </div> </a> <ul id="toc-Curiosità-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Bibliografia" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Bibliografia"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Bibliografia</span> </div> </a> <ul id="toc-Bibliografia-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Voci_correlate" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Voci_correlate"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Voci correlate</span> </div> </a> <ul id="toc-Voci_correlate-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Altri_progetti" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Altri_progetti"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>Altri progetti</span> </div> </a> <ul id="toc-Altri_progetti-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Indice" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Mostra/Nascondi l'indice" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Mostra/Nascondi l'indice</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">DNA polimerasi (DNA-dipendente)</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Vai a una voce in un'altra lingua. Disponibile in 49 lingue" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-49" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">49 lingue</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A8%D9%88%D9%84%D9%8A%D9%85%D8%B1%D8%A7%D8%B2_%D8%A7%D9%84%D8%AF%D9%86%D8%A7" title="بوليمراز الدنا - arabo" lang="ar" hreflang="ar" data-title="بوليمراز الدنا" data-language-autonym="العربية" data-language-local-name="arabo" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/DNK_polimeraza" title="DNK polimeraza - bosniaco" lang="bs" hreflang="bs" data-title="DNK polimeraza" data-language-autonym="Bosanski" data-language-local-name="bosniaco" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Polimerasa_d%27ADN" title="Polimerasa d'ADN - catalano" lang="ca" hreflang="ca" data-title="Polimerasa d'ADN" data-language-autonym="Català" data-language-local-name="catalano" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-ckb mw-list-item"><a href="https://ckb.wikipedia.org/wiki/%D9%BE%DB%86%D9%84%DB%8C%D9%85%DB%95%D8%B1%DB%95%DB%8C%D8%B2%DB%8C_%D8%AF%DB%8C_%D8%A6%DB%8E%D9%86_%D8%A6%DB%95%DB%8C" title="پۆلیمەرەیزی دی ئێن ئەی - curdo centrale" lang="ckb" hreflang="ckb" data-title="پۆلیمەرەیزی دی ئێن ئەی" data-language-autonym="کوردی" data-language-local-name="curdo centrale" class="interlanguage-link-target"><span>کوردی</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/DNA_polymer%C3%A1za" title="DNA polymeráza - ceco" lang="cs" hreflang="cs" data-title="DNA polymeráza" data-language-autonym="Čeština" data-language-local-name="ceco" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/DNA-polymerase" title="DNA-polymerase - danese" lang="da" hreflang="da" data-title="DNA-polymerase" data-language-autonym="Dansk" data-language-local-name="danese" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/DNA-Polymerasen" title="DNA-Polymerasen - tedesco" lang="de" hreflang="de" data-title="DNA-Polymerasen" data-language-autonym="Deutsch" data-language-local-name="tedesco" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/DNA_%CF%80%CE%BF%CE%BB%CF%85%CE%BC%CE%B5%CF%81%CE%AC%CF%83%CE%B7" title="DNA πολυμεράση - greco" lang="el" hreflang="el" data-title="DNA πολυμεράση" data-language-autonym="Ελληνικά" data-language-local-name="greco" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/DNA_polymerase" title="DNA polymerase - inglese" lang="en" hreflang="en" data-title="DNA polymerase" data-language-autonym="English" data-language-local-name="inglese" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/ADN_polimerasa" title="ADN polimerasa - spagnolo" lang="es" hreflang="es" data-title="ADN polimerasa" data-language-autonym="Español" data-language-local-name="spagnolo" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/DNA_pol%C3%BCmeraasid" title="DNA polümeraasid - estone" lang="et" hreflang="et" data-title="DNA polümeraasid" data-language-autonym="Eesti" data-language-local-name="estone" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/DNA_polimerasa" title="DNA polimerasa - basco" lang="eu" hreflang="eu" data-title="DNA polimerasa" data-language-autonym="Euskara" data-language-local-name="basco" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%AF%DB%8C%E2%80%8C%D8%A7%D9%86%E2%80%8C%D8%A7%DB%8C_%D9%BE%D9%84%DB%8C%D9%85%D8%B1%D8%A7%D8%B2" title="دی‌ان‌ای پلیمراز - persiano" lang="fa" hreflang="fa" data-title="دی‌ان‌ای پلیمراز" data-language-autonym="فارسی" data-language-local-name="persiano" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/DNA-polymeraasi" title="DNA-polymeraasi - finlandese" lang="fi" hreflang="fi" data-title="DNA-polymeraasi" data-language-autonym="Suomi" data-language-local-name="finlandese" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/ADN_polym%C3%A9rase" title="ADN polymérase - francese" lang="fr" hreflang="fr" data-title="ADN polymérase" data-language-autonym="Français" data-language-local-name="francese" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/ADN_polimerase" title="ADN polimerase - galiziano" lang="gl" hreflang="gl" data-title="ADN polimerase" data-language-autonym="Galego" data-language-local-name="galiziano" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/DNA_%D7%A4%D7%95%D7%9C%D7%99%D7%9E%D7%A8%D7%90%D7%96" title="DNA פולימראז - ebraico" lang="he" hreflang="he" data-title="DNA פולימראז" data-language-autonym="עברית" data-language-local-name="ebraico" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/DNK_polimeraza" title="DNK polimeraza - croato" lang="hr" hreflang="hr" data-title="DNK polimeraza" data-language-autonym="Hrvatski" data-language-local-name="croato" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/DNS-polimer%C3%A1z" title="DNS-polimeráz - ungherese" lang="hu" hreflang="hu" data-title="DNS-polimeráz" data-language-autonym="Magyar" data-language-local-name="ungherese" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D4%B4%D5%86%D4%B9-%D5%BA%D5%B8%D5%AC%D5%AB%D5%B4%D5%A5%D6%80%D5%A1%D5%A6" title="ԴՆԹ-պոլիմերազ - armeno" lang="hy" hreflang="hy" data-title="ԴՆԹ-պոլիմերազ" data-language-autonym="Հայերեն" data-language-local-name="armeno" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/DNA_polimerase" title="DNA polimerase - indonesiano" lang="id" hreflang="id" data-title="DNA polimerase" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonesiano" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-inh mw-list-item"><a href="https://inh.wikipedia.org/wiki/%D0%94%D0%9D%D0%9A-%D0%BF%D0%BE%D0%BB%D0%B8%D0%BC%D0%B5%D1%80%D0%B0%D0%B7%D0%B0" title="ДНК-полимераза - ingush" lang="inh" hreflang="inh" data-title="ДНК-полимераза" data-language-autonym="ГӀалгӀай" data-language-local-name="ingush" class="interlanguage-link-target"><span>ГӀалгӀай</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/DNA%E3%83%9D%E3%83%AA%E3%83%A1%E3%83%A9%E3%83%BC%E3%82%BC" title="DNAポリメラーゼ - giapponese" lang="ja" hreflang="ja" data-title="DNAポリメラーゼ" data-language-autonym="日本語" data-language-local-name="giapponese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ka mw-list-item"><a href="https://ka.wikipedia.org/wiki/%E1%83%93%E1%83%9C%E1%83%9B-%E1%83%9E%E1%83%9D%E1%83%9A%E1%83%98%E1%83%9B%E1%83%94%E1%83%A0%E1%83%90%E1%83%96%E1%83%90" title="დნმ-პოლიმერაზა - georgiano" lang="ka" hreflang="ka" data-title="დნმ-პოლიმერაზა" data-language-autonym="ქართული" data-language-local-name="georgiano" class="interlanguage-link-target"><span>ქართული</span></a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%94%D0%9D%D2%9A-%D0%BF%D0%BE%D0%BB%D0%B8%D0%BC%D0%B5%D1%80%D0%B0%D0%B7%D0%B0" title="ДНҚ-полимераза - kazako" lang="kk" hreflang="kk" data-title="ДНҚ-полимераза" data-language-autonym="Қазақша" data-language-local-name="kazako" class="interlanguage-link-target"><span>Қазақша</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/DNA_%EC%A4%91%ED%95%A9%ED%9A%A8%EC%86%8C" title="DNA 중합효소 - coreano" lang="ko" hreflang="ko" data-title="DNA 중합효소" data-language-autonym="한국어" data-language-local-name="coreano" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/DNR_polimeraz%C4%97" title="DNR polimerazė - lituano" lang="lt" hreflang="lt" data-title="DNR polimerazė" data-language-autonym="Lietuvių" data-language-local-name="lituano" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%94%D0%9D%D0%9A-%D0%BF%D0%BE%D0%BB%D0%B8%D0%BC%D0%B5%D1%80%D0%B0%D0%B7%D0%B0" title="ДНК-полимераза - macedone" lang="mk" hreflang="mk" data-title="ДНК-полимераза" data-language-autonym="Македонски" data-language-local-name="macedone" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-mn mw-list-item"><a href="https://mn.wikipedia.org/wiki/%D0%94%D0%9D%D0%A5_%D0%BF%D0%BE%D0%BB%D0%B8%D0%BC%D0%B5%D1%80%D0%B0%D0%B7%D0%B0" title="ДНХ полимераза - mongolo" lang="mn" hreflang="mn" data-title="ДНХ полимераза" data-language-autonym="Монгол" data-language-local-name="mongolo" class="interlanguage-link-target"><span>Монгол</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/DNA_polimerase" title="DNA polimerase - malese" lang="ms" hreflang="ms" data-title="DNA polimerase" data-language-autonym="Bahasa Melayu" data-language-local-name="malese" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/DNA-polymerase" title="DNA-polymerase - olandese" lang="nl" hreflang="nl" data-title="DNA-polymerase" data-language-autonym="Nederlands" data-language-local-name="olandese" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-nn mw-list-item"><a href="https://nn.wikipedia.org/wiki/DNA-polymerase" title="DNA-polymerase - norvegese nynorsk" lang="nn" hreflang="nn" data-title="DNA-polymerase" data-language-autonym="Norsk nynorsk" data-language-local-name="norvegese nynorsk" class="interlanguage-link-target"><span>Norsk nynorsk</span></a></li><li class="interlanguage-link interwiki-oc mw-list-item"><a href="https://oc.wikipedia.org/wiki/ADN_polimerasa" title="ADN polimerasa - occitano" lang="oc" hreflang="oc" data-title="ADN polimerasa" data-language-autonym="Occitan" data-language-local-name="occitano" class="interlanguage-link-target"><span>Occitan</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Polimeraza_DNA" title="Polimeraza DNA - polacco" lang="pl" hreflang="pl" data-title="Polimeraza DNA" data-language-autonym="Polski" data-language-local-name="polacco" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/ADN_polimerase" title="ADN polimerase - portoghese" lang="pt" hreflang="pt" data-title="ADN polimerase" data-language-autonym="Português" data-language-local-name="portoghese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/ADN_polimeraz%C4%83" title="ADN polimerază - rumeno" lang="ro" hreflang="ro" data-title="ADN polimerază" data-language-autonym="Română" data-language-local-name="rumeno" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%94%D0%9D%D0%9A-%D0%BF%D0%BE%D0%BB%D0%B8%D0%BC%D0%B5%D1%80%D0%B0%D0%B7%D0%B0" title="ДНК-полимераза - russo" lang="ru" hreflang="ru" data-title="ДНК-полимераза" data-language-autonym="Русский" data-language-local-name="russo" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/DNK_polimeraza" title="DNK polimeraza - serbo-croato" lang="sh" hreflang="sh" data-title="DNK polimeraza" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbo-croato" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/DNA_polymerase" title="DNA polymerase - Simple English" lang="en-simple" hreflang="en-simple" data-title="DNA polymerase" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/DNA_polymer%C3%A1za" title="DNA polymeráza - slovacco" lang="sk" hreflang="sk" data-title="DNA polymeráza" data-language-autonym="Slovenčina" data-language-local-name="slovacco" class="interlanguage-link-target"><span>Slovenčina</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/DNK-polimeraza" title="DNK-polimeraza - sloveno" lang="sl" hreflang="sl" data-title="DNK-polimeraza" data-language-autonym="Slovenščina" data-language-local-name="sloveno" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%94%D0%9D%D0%9A_%D0%BF%D0%BE%D0%BB%D0%B8%D0%BC%D0%B5%D1%80%D0%B0%D0%B7%D0%B0" title="ДНК полимераза - serbo" lang="sr" hreflang="sr" data-title="ДНК полимераза" data-language-autonym="Српски / srpski" data-language-local-name="serbo" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/DNA-polymeras" title="DNA-polymeras - svedese" lang="sv" hreflang="sv" data-title="DNA-polymeras" data-language-autonym="Svenska" data-language-local-name="svedese" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%9F%E0%AE%BF._%E0%AE%8E%E0%AE%A9%E0%AF%8D._%E0%AE%8F_%E0%AE%AA%E0%AE%BE%E0%AE%B2%E0%AE%BF%E0%AE%AE%E0%AE%B0%E0%AF%87%E0%AE%9A%E0%AF%81" title="டி. என். ஏ பாலிமரேசு - tamil" lang="ta" hreflang="ta" data-title="டி. என். ஏ பாலிமரேசு" data-language-autonym="தமிழ்" data-language-local-name="tamil" class="interlanguage-link-target"><span>தமிழ்</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B8%94%E0%B8%B5%E0%B9%80%E0%B8%AD%E0%B9%87%E0%B8%99%E0%B9%80%E0%B8%AD%E0%B8%9E%E0%B8%AD%E0%B8%A5%E0%B8%B4%E0%B9%80%E0%B8%A1%E0%B8%AD%E0%B9%80%E0%B8%A3%E0%B8%AA" title="ดีเอ็นเอพอลิเมอเรส - thailandese" lang="th" hreflang="th" data-title="ดีเอ็นเอพอลิเมอเรส" data-language-autonym="ไทย" data-language-local-name="thailandese" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/DNA_polimeraz" title="DNA polimeraz - turco" lang="tr" hreflang="tr" data-title="DNA polimeraz" data-language-autonym="Türkçe" data-language-local-name="turco" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%94%D0%9D%D0%9A-%D0%BF%D0%BE%D0%BB%D1%96%D0%BC%D0%B5%D1%80%D0%B0%D0%B7%D0%B0" title="ДНК-полімераза - ucraino" lang="uk" hreflang="uk" data-title="ДНК-полімераза" data-language-autonym="Українська" data-language-local-name="ucraino" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/DNA_polymerase" title="DNA polymerase - vietnamita" lang="vi" hreflang="vi" data-title="DNA polymerase" data-language-autonym="Tiếng Việt" data-language-local-name="vietnamita" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/DNA%E8%81%9A%E5%90%88%E9%85%B6" title="DNA聚合酶 - cinese" lang="zh" hreflang="zh" data-title="DNA聚合酶" data-language-autonym="中文" data-language-local-name="cinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q206286#sitelinks-wikipedia" title="Modifica collegamenti interlinguistici" class="wbc-editpage">Modifica collegamenti</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespace"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/DNA_polimerasi_(DNA-dipendente)" title="Vedi la voce [c]" accesskey="c"><span>Voce</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Discussione:DNA_polimerasi_(DNA-dipendente)" rel="discussion" title="Vedi le discussioni relative a questa pagina [t]" accesskey="t"><span>Discussione</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Cambia versione linguistica" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">italiano</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Visite"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/DNA_polimerasi_(DNA-dipendente)"><span>Leggi</span></a></li><li id="ca-ve-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&veaction=edit" title="Modifica questa pagina [v]" accesskey="v"><span>Modifica</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=edit" title="Modifica il wikitesto di questa pagina [e]" accesskey="e"><span>Modifica wikitesto</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=history" title="Versioni precedenti di questa pagina [h]" accesskey="h"><span>Cronologia</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Strumenti pagine"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Strumenti" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Strumenti</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Strumenti</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">sposta nella barra laterale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">nascondi</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Altre opzioni" > <div class="vector-menu-heading"> Azioni </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/DNA_polimerasi_(DNA-dipendente)"><span>Leggi</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&veaction=edit" title="Modifica questa pagina [v]" accesskey="v"><span>Modifica</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=edit" title="Modifica il wikitesto di questa pagina [e]" accesskey="e"><span>Modifica wikitesto</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=history"><span>Cronologia</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> Generale </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Speciale:PuntanoQui/DNA_polimerasi_(DNA-dipendente)" title="Elenco di tutte le pagine che sono collegate a questa [j]" accesskey="j"><span>Puntano qui</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Speciale:ModificheCorrelate/DNA_polimerasi_(DNA-dipendente)" rel="nofollow" title="Elenco delle ultime modifiche alle pagine collegate a questa [k]" accesskey="k"><span>Modifiche correlate</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Speciale:PagineSpeciali" title="Elenco di tutte le pagine speciali [q]" accesskey="q"><span>Pagine speciali</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&oldid=141865276" title="Collegamento permanente a questa versione di questa pagina"><span>Link permanente</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=info" title="Ulteriori informazioni su questa pagina"><span>Informazioni pagina</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Speciale:Cita&page=DNA_polimerasi_%28DNA-dipendente%29&id=141865276&wpFormIdentifier=titleform" title="Informazioni su come citare questa pagina"><span>Cita questa voce</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Speciale:UrlShortener&url=https%3A%2F%2Fit.wikipedia.org%2Fwiki%2FDNA_polimerasi_%28DNA-dipendente%29"><span>Ottieni URL breve</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Speciale:QrCode&url=https%3A%2F%2Fit.wikipedia.org%2Fwiki%2FDNA_polimerasi_%28DNA-dipendente%29"><span>Scarica codice QR</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Stampa/esporta </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-create_a_book" class="mw-list-item"><a href="/w/index.php?title=Speciale:Libro&bookcmd=book_creator&referer=DNA+polimerasi+%28DNA-dipendente%29"><span>Crea un libro</span></a></li><li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Speciale:DownloadAsPdf&page=DNA_polimerasi_%28DNA-dipendente%29&action=show-download-screen"><span>Scarica come PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&printable=yes" title="Versione stampabile di questa pagina [p]" accesskey="p"><span>Versione stampabile</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> In altri progetti </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="wb-otherproject-link wb-otherproject-commons mw-list-item"><a href="https://commons.wikimedia.org/wiki/Category:DNA_polymerases" hreflang="en"><span>Wikimedia Commons</span></a></li><li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q206286" title="Collegamento all'elemento connesso dell'archivio dati [g]" accesskey="g"><span>Elemento Wikidata</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Strumenti pagine"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Aspetto"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Aspetto</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">sposta nella barra laterale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">nascondi</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Da Wikipedia, l'enciclopedia libera.</div> </div> <div id="contentSub"><div id="mw-content-subtitle"><span class="mw-redirectedfrom">(Reindirizzamento da <strong><a href="/w/index.php?title=DNA_polimerasi&redirect=no" class="mw-redirect" title="DNA polimerasi">DNA polimerasi</a></strong>)</span></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="it" dir="ltr"><style data-mw-deduplicate="TemplateStyles:r130658281">body:not(.skin-minerva) .mw-parser-output .hatnote.nota-disambigua{clear:both;margin-top:0;padding:.05em .5em}</style> <style data-mw-deduplicate="TemplateStyles:r139142988">.mw-parser-output .hatnote-content{align-items:center;display:flex}.mw-parser-output .hatnote-icon{flex-shrink:0}.mw-parser-output .hatnote-icon img{display:flex}.mw-parser-output .hatnote-text{font-style:italic}body:not(.skin-minerva) .mw-parser-output .hatnote{border:1px solid #CCC;display:flex;margin:.5em 0;padding:.2em .5em}body:not(.skin-minerva) .mw-parser-output .hatnote-text{padding-left:.5em}body.skin-minerva .mw-parser-output .hatnote-icon{padding-right:8px}body.skin-minerva .mw-parser-output .hatnote-icon img{height:auto;width:16px}body.skin--responsive .mw-parser-output .hatnote a.new{color:#d73333}body.skin--responsive .mw-parser-output .hatnote a.new:visited{color:#a55858}</style> <div class="hatnote noprint nota-disambigua"> <div class="hatnote-content"><span class="noviewer hatnote-icon" typeof="mw:File"><span><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/bc/Nota_disambigua.svg/18px-Nota_disambigua.svg.png" decoding="async" width="18" height="18" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/bc/Nota_disambigua.svg/27px-Nota_disambigua.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/bc/Nota_disambigua.svg/36px-Nota_disambigua.svg.png 2x" data-file-width="200" data-file-height="200" /></span></span> <span class="hatnote-text"><a href="/wiki/Aiuto:Disambiguazione" title="Aiuto:Disambiguazione">Disambiguazione</a> – "DNA polimerasi" rimanda qui. Se stai cercando DNA polimerasi RNA-dipendente, vedi <b><a href="/wiki/DNA_polimerasi_(RNA-dipendente)" title="DNA polimerasi (RNA-dipendente)">DNA polimerasi (RNA-dipendente)</a></b>.</span></div> </div> <table class="infobox sinottico" summary="Tabella sinottica che riassume i principali dati del soggetto"><tbody><tr class="sinottico_testata"><th colspan="2" style="background: #C2C3FF; color:#000;">DNA polimerasi</th></tr><tr><td class="sinottico_testo_centrale" colspan="2"><span typeof="mw:File"><a href="/wiki/File:DNA_polymerase.png" class="mw-file-description" title="Modello tridimensionale dell'enzima"><img alt="Modello tridimensionale dell'enzima" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/90/DNA_polymerase.png/220px-DNA_polymerase.png" decoding="async" width="220" height="219" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/90/DNA_polymerase.png/330px-DNA_polymerase.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/90/DNA_polymerase.png/440px-DNA_polymerase.png 2x" data-file-width="738" data-file-height="734" /></a></span><br /><small>Struttura tridimensionale della DNA polimerasi</small></td></tr><tr><th><a href="/wiki/Classificazione_EC" title="Classificazione EC">Numero EC</a></th><td>2.7.7.7 </td></tr><tr><th>Classe</th><td><a href="/wiki/Transferasi" title="Transferasi">Transferasi</a> </td></tr><tr class="sinottico_divisione"><th colspan="2">Nome sistematico</th></tr><tr><td class="sinottico_testo_centrale" colspan="2">deossinucleoside-trifosfato:DNA deossinucleotidiltransferasi (DNA diretta) </td></tr><tr class="sinottico_divisione"><th colspan="2">Altri nomi</th></tr><tr><td class="sinottico_testo_centrale" colspan="2">DNA polimerasi I; DNA polimerasi II; DNA polimerasi III; polimerasi dell'acido deossiribonucleico; DNA duplicasi, DNA nucleotidiltransferasi, frammento di Klenow, Taq DNA polimerasi, Taq Pol I. </td></tr><tr><th>Banche dati</th><td><a rel="nofollow" class="external text" href="http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7">BRENDA</a>, <a rel="nofollow" class="external text" href="http://enzyme.expasy.org/EC/2.7.7.7">EXPASY</a>, <a rel="nofollow" class="external text" href="http://xpdb.nist.gov/enzyme_thermodynamics/enzyme_compose_query.pl?EC=2.7.7.7">GTD</a>, PDB (<a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity.rcsb_ec_lineage.id:2.7.7.7">RCSB PDB</a> <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?ec_number:2.7.7.7">PDBe</a> <a rel="nofollow" class="external text" href="https://pdbj.org/mine/sql?query=SELECT+DISTINCT+pdbid+FROM+entity+WHERE+entity.pdbx_ec%3D%272.7.7.7%27">PDBj</a> <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/enzymes/GetPage.pl?ec_number=2.7.7.7">PDBsum</a>) </td></tr><tr><td colspan="2" class="sinottico_piede" style="background:#FFC253; color:#000;">Fonte: <a rel="nofollow" class="external text" href="http://www.enzyme-database.org/query.php?ec=2.7.7.7">IUBMB</a> </td></tr><tr><td class="sinottico_piede2 noprint nomobile metadata" colspan="2"><a href="https://www.wikidata.org/wiki/Q206286" class="extiw" title="d:Q206286"><span title="Modifica i dati della voce DNA polimerasi (DNA-dipendente) su Wikidata">Modifica dati su Wikidata</span></a><b> ·</b> <a href="/wiki/Template:Enzima/man" title="Template:Enzima/man"><span title="Manuale del template Enzima">Manuale</span></a></td></tr></tbody></table> <p>Le <b>DNA polimerasi (DNA-dipendente)</b> sono <a href="/wiki/Enzima" title="Enzima">enzimi</a> appartenenti alla categoria delle <a href="/wiki/Transferasi" title="Transferasi">transferasi</a>, che catalizzano la seguente reazione: </p><p><i>deossi<a href="/wiki/Nucleoside" title="Nucleoside">nucleoside</a> tri<a href="/wiki/Fosfato" title="Fosfato">fosfato</a> + <a href="/wiki/DNA" title="DNA">DNA</a><sub>n</sub> ⇄ difosfato + DNA<sub>n+1</sub></i>. </p><p>Questi enzimi sono in grado di sintetizzare da un filamento di <a href="/wiki/DNA" title="DNA">DNA</a> utilizzando come stampo (più conosciuto con il termine inglese "template") un altro filamento di <a href="/wiki/DNA" title="DNA">DNA</a>, generando quindi un filamento complementare al primo nel processo di <a href="/wiki/Replicazione_del_DNA" title="Replicazione del DNA">replicazione</a>. </p><p>Tutte le DNA polimerasi conosciute sintetizzano il nuovo filamento in direzione 5'- 3' aggiungendo <a href="/wiki/Deossiribonucleotide" title="Deossiribonucleotide">deossiribonucleotidi</a> (dNTP) al gruppo 3'-OH del <a href="/wiki/Deossiribosio" title="Deossiribosio">deossiribosio</a> del nucleotide precedente. Nessuna DNA-polimerasi è in grado di iniziare la sintesi di un filamento "da zero" (<i>ex novo</i>). Per questa ragione le DNA-polimerasi necessitano di un oligonucleotide (in inglese "<a href="/wiki/Primers" class="mw-redirect" title="Primers">primers</a>") complementare al filamento templato. Questo primer è costituito da poche decine di nucleotidi e funge da innesco della reazione di amplificazione perché fornisce un gruppo idrossilico (-OH) in posizione 3' a cui la DNA polimerasi legherà il primo nucleotide del filamento neosintetizzato. Tali inneschi possono essere sia di <a href="/wiki/DNA" title="DNA">DNA</a> sia di <a href="/wiki/RNA" title="RNA">RNA</a>. Durante la replicazione <i>in vivo</i> tali inneschi di RNA sono forniti da una speciale RNA polimerasi detta <a href="/wiki/Primasi" title="Primasi">primasi</a>. </p><p>Questi inneschi verranno poi eliminati grazie ad alcuni tipi particolari di <a href="/wiki/RNAsi" class="mw-redirect" title="RNAsi">RNAsi</a>, enzimi capaci di degradare l'<a href="/wiki/RNA" title="RNA">RNA</a>. Sarà poi compito dell'enzima DNA <a href="/wiki/Ligasi" title="Ligasi">ligasi</a> legare l'estremità 3' del nuovo tratto sintetizzato con l'estremità 5' del tratto di DNA precedente. </p><p>I <a href="/wiki/Retrovirus" title="Retrovirus">retrovirus</a> possiedono una particolare DNA-polimerasi chiamata <i><a href="/wiki/Transcrittasi_inversa" class="mw-redirect" title="Transcrittasi inversa">transcrittasi inversa</a></i>, che è una DNA-polimerasi RNA-dipendente (<i>RdDp</i>) ed è in grado di sintetizzare un filamento di <a href="/wiki/DNA" title="DNA">DNA</a> partendo da uno stampo di <a href="/wiki/RNA" title="RNA">RNA</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Attività_esonucleasica"><span id="Attivit.C3.A0_esonucleasica"></span>Attività esonucleasica</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&veaction=edit&section=1" title="Modifica la sezione Attività esonucleasica" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=edit&section=1" title="Edit section's source code: Attività esonucleasica"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Alcune <i>DNA polimerasi</i> sono dotate di attività <a href="/wiki/Esonucleasi" title="Esonucleasi">esonucleasica</a>, vale a dire che sono in grado di rimuovere <a href="/wiki/Nucleotidi" class="mw-redirect" title="Nucleotidi">nucleotidi</a> da un filamento di DNA. L'attività esonucleasica delle DNA polimerasi può avvenire in direzione 5'-3' o in direzione 3'-5'. Poiché la replicazione avviene in direzione 5'-3' allora l'attività esonucleasica 5'-3' (nella stessa direzione in cui viene sintetizzato il nuovo filamento) rimuove nucleotidi che si trovano a valle rispetto alla DNA polimerasi. L'attività esonucleasica 3'-5' (in direzione contraria alla sintesi del nuovo filamento) detta <i>proofreading</i>, permette di ridurre notevolmente il tasso d'errore della DNA polimerasi consentendo la rimozione di eventuali nucleotidi scorretti appena incorporati. In questo modo, la cellula diminuisce di molto l'incidenza di mutazioni (possibili future <a href="/wiki/Neoplasia" title="Neoplasia">neoplasie</a>) nel proprio DNA. </p> <div class="mw-heading mw-heading2"><h2 id="DNA_polimerasi_procariotiche">DNA polimerasi procariotiche</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&veaction=edit&section=2" title="Modifica la sezione DNA polimerasi procariotiche" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=edit&section=2" title="Edit section's source code: DNA polimerasi procariotiche"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Nei procarioti il termine <i>DNA polimerasi</i> può riferirsi a ciascuno dei 5 enzimi ad attività DNA polimerasica che hanno diverse funzioni nella replicazione del <a href="/wiki/DNA" title="DNA">DNA</a>. </p><p>Questi sono: </p> <table class="wikitable"> <tbody><tr> <td><b>Enzima</b></td> <td><b>Funzione</b></td> <td><b>Attività <a href="/wiki/Esonucleasi" title="Esonucleasi">esonucleasica</a></b> </td></tr> <tr> <td><a href="/wiki/DNA_polimerasi_I" title="DNA polimerasi I">DNA polimerasi I</a></td> <td>Riparazione del DNA, replicazione</td> <td>3'-5' e 5'-3' </td></tr> <tr> <td><a href="/wiki/DNA_polimerasi_II" title="DNA polimerasi II">DNA polimerasi II</a></td> <td>Riparazione del DNA</td> <td>3'-5' </td></tr> <tr> <td><a href="/wiki/DNA_polimerasi_III" title="DNA polimerasi III">DNA polimerasi III</a></td> <td>complesso multimerico, principale fattore replicativo</td> <td>3'-5' </td></tr> <tr> <td><a href="/w/index.php?title=DNA_polimerasi_IV&action=edit&redlink=1" class="new" title="DNA polimerasi IV (la pagina non esiste)">DNA polimerasi IV</a></td> <td>Riparazione del DNA, sintesi delle translesioni </td> <td>3'-5' </td></tr> <tr> <td><a href="/wiki/DNA_polimerasi_V" title="DNA polimerasi V">DNA polimerasi V</a></td> <td>Riparazione del DNA, sintesi delle translesioni </td> <td>3'-5' </td></tr></tbody></table> <div class="mw-heading mw-heading3"><h3 id="DNA_polimerasi_V">DNA polimerasi V</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&veaction=edit&section=3" title="Modifica la sezione DNA polimerasi V" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=edit&section=3" title="Edit section's source code: DNA polimerasi V"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>È formata da due subunità, UnuC ed UnuD. Insieme alla <a href="/w/index.php?title=DNA_polimerasi_IV&action=edit&redlink=1" class="new" title="DNA polimerasi IV (la pagina non esiste)">DNA polimerasi IV</a>, la <a href="/wiki/DNA_polimerasi_V" title="DNA polimerasi V">DNA polimerasi V</a> fa parte della famiglia Y. </p> <div class="mw-heading mw-heading2"><h2 id="DNA_polimerasi_eucariotiche">DNA polimerasi eucariotiche</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&veaction=edit&section=4" title="Modifica la sezione DNA polimerasi eucariotiche" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=edit&section=4" title="Edit section's source code: DNA polimerasi eucariotiche"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Negli eucarioti le diverse <i>DNA polimerasi</i> sono nominate attraverso l'uso delle lettere dell'alfabeto greco. Le principali DNA polimerasi eucariotiche sono: </p> <table class="wikitable"> <tbody><tr> <td><b>Enzima</b></td> <td><b>Funzione</b></td> <td><b>Attività esonucleasica</b> </td></tr> <tr> <td><a href="/wiki/DNA_polimerasi_%CE%B1" class="mw-redirect" title="DNA polimerasi α">DNA polimerasi α</a></td> <td>Primo allungamento degli inneschi di RNA durante la replicazione</td> <td>No </td></tr> <tr> <td><a href="/w/index.php?title=DNA_polimerasi_%CE%B2&action=edit&redlink=1" class="new" title="DNA polimerasi β (la pagina non esiste)">DNA polimerasi β</a></td> <td>Riparazione del DNA e "gap filling"</td> <td>5'-3' </td></tr> <tr> <td><a href="/wiki/DNA_polimerasi_%CE%B3" class="mw-redirect" title="DNA polimerasi γ">DNA polimerasi γ</a></td> <td>Replicazione del DNA mitocondriale</td> <td>5'-3' </td></tr> <tr> <td><a href="/wiki/DNA_polimerasi_%CE%B4" class="mw-redirect" title="DNA polimerasi δ">DNA polimerasi δ</a></td> <td>Principale fattore replicativo, sintetizza il DNA sia sul filamento lagging che sul filamento leading</td> <td>3'-5' </td></tr> <tr> <td><a href="/wiki/DNA_polimerasi_%CE%B5" class="mw-redirect" title="DNA polimerasi ε">DNA polimerasi ε</a></td> <td>Replicazione del DNA, sintetizza il DNA sul filamento leading</td> <td>3'-5' </td></tr> <tr> <td><a href="/w/index.php?title=DNA_polimerasi_%CE%B7&action=edit&redlink=1" class="new" title="DNA polimerasi η (la pagina non esiste)">DNA polimerasi η</a></td> <td>Sintesi da translesione</td> <td>No </td></tr></tbody></table> <div class="mw-heading mw-heading3"><h3 id="DNA_polimerasi_γ"><span id="DNA_polimerasi_.CE.B3"></span>DNA polimerasi γ</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&veaction=edit&section=5" title="Modifica la sezione DNA polimerasi γ" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=edit&section=5" title="Edit section's source code: DNA polimerasi γ"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Si occupa esclusivamente della <a href="/wiki/Replicazione_del_DNA" title="Replicazione del DNA">replicazione</a> del <a href="/wiki/DNA_mitocondriale" title="DNA mitocondriale">DNA mitocondriale</a>. Per questo motivo essa risulta essere presente solo nella matrice mitocondriale interna. </p> <div class="mw-heading mw-heading3"><h3 id="DNA_polimerasi_δ"><span id="DNA_polimerasi_.CE.B4"></span>DNA polimerasi δ</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&veaction=edit&section=6" title="Modifica la sezione DNA polimerasi δ" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=edit&section=6" title="Edit section's source code: DNA polimerasi δ"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Si occupa di eliminare i Primer ad <a href="/wiki/RNA" title="RNA">RNA</a>, mediante azione esonucleasica 5' -> 3', e di sostituirli con <a href="/wiki/Nucleotidi" class="mw-redirect" title="Nucleotidi">nucleotidi</a> a <a href="/wiki/DNA" title="DNA">DNA</a> mediante azione <a href="/wiki/Polimero" title="Polimero">polimerica</a> 5' -> 3'. Agisce sul <a href="/wiki/Filamento_lagging" title="Filamento lagging">filamento lagging</a>. </p> <div class="mw-heading mw-heading3"><h3 id="DNA_polimerasi_ε"><span id="DNA_polimerasi_.CE.B5"></span>DNA polimerasi ε</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&veaction=edit&section=7" title="Modifica la sezione DNA polimerasi ε" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=edit&section=7" title="Edit section's source code: DNA polimerasi ε"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Si occupa della <a href="/wiki/Replicazione_del_DNA" title="Replicazione del DNA">duplicazione</a> del filamento leading di DNA, associata alla DNA polimerasi alfa. Possiede attività <a href="/wiki/Polimero" title="Polimero">polimerica</a> 5' -> 3'. </p> <div class="mw-heading mw-heading2"><h2 id="Farmacologia">Farmacologia</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&veaction=edit&section=8" title="Modifica la sezione Farmacologia" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=edit&section=8" title="Edit section's source code: Farmacologia"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Essendo essenziale alla sintesi del DNA, il blocco farmacologico della DNA polimerasi α può essere sfruttato a scopo terapeutico. Tra i farmaci antitumorali ne esiste uno in particolare che ha questa proprietà, la <a href="/wiki/Citarabina" title="Citarabina">citarabina</a> o citosina arabinoside, usata contro leucemie mieloidi acute, nei linfomi e a basso dosaggio nel mantenimento delle mielodisplasie. </p><p>La DNA polimerasi β, invece, è inibita da due coloranti, il <b>verde naftocromo</b> ed il <b>mordente blu</b>, entrambi derivati dal <a href="/wiki/Difenilmetano" title="Difenilmetano">difenilmetano</a>. A scopo di studio di laboratorio, sono stati identificati altri inibitori di questa polimerasi come lo <b>NSC624548</b>, che hanno permesso di studiare più in dettaglio le sue funzioni biologiche connesse alla riparazione del DNA. </p> <div class="mw-heading mw-heading2"><h2 id="Curiosità"><span id="Curiosit.C3.A0"></span>Curiosità</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&veaction=edit&section=9" title="Modifica la sezione Curiosità" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=edit&section=9" title="Edit section's source code: Curiosità"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Nel 1989, in seguito al grande successo riscosso nella comunità scientifica dalla tecnica della <a href="/wiki/Reazione_a_catena_della_polimerasi" title="Reazione a catena della polimerasi">PCR (reazione a catena della polimerasi)</a>, inventata qualche anno prima, la DNA polimerasi è stata insignita del titolo, istituito <i>ad hoc</i>, di "Molecola dell'anno". </p> <div class="mw-heading mw-heading2"><h2 id="Bibliografia">Bibliografia</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&veaction=edit&section=10" title="Modifica la sezione Bibliografia" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=edit&section=10" title="Edit section's source code: Bibliografia"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Bollum, F.J. <i>Calf thymus polymerase.</i> J. Biol. Chem. 235 (1960) 2399–2403. <a href="/wiki/Entrez" title="Entrez">Entrez PubMed</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=13802334">13802334</a></li> <li>Falaschi, A. e Kornberg, A. <i>Biochemical studies of bacterial sporulation. II. Deoxy-ribonucleic acid polymerase in spores of Bacillus subtilis.</i> J. Biol. Chem. 241 (1966) 1478–1482. <a href="/wiki/Entrez" title="Entrez">Entrez PubMed</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=4957767">4957767</a></li> <li>Lehman, I.R., Bessman, M.J., Simms, E.S. e Kornberg, A. <i>Enzymatic synthesis of deoxyribonucleic acid. I. Preparation of substrates and partial purification of an enzyme from Escherichia coli.</i> J. Biol. Chem. 233 (1958) 163–170. <a href="/wiki/Entrez" title="Entrez">Entrez PubMed</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=13563462">13563462</a></li> <li>Richardson, C.C., Schildkraut, C.L., Aposhian, H.V. e Kornberg, A. <i>Enzymatic synthesis of deoxyribonucleic acid. XIV. Further purification and properties of deoxyribonucleic acid polymerase of Escherichia coli.</i> J. Biol. Chem. 239 (1964) 222–232.</li> <li>Schachman, H.K., Adler, J., Radding, C.M., Lehman, I.R. e Kornberg, A. <i>Enzymatic synthesis of deoxyribonucleic acid. VII. Synthesis of a polymer of deoxyadenylate and deoxythymidylate.</i> J. Biol. Chem. 235 (1960) 3242–3249.</li> <li>Zimmerman, B.K. <i>Purification and properties of deoxyribonucleic acid polymerase from Micrococcus lysodeikticus.</i> J. Biol. Chem. 241 (1966) 2035–2041. <a href="/wiki/Entrez" title="Entrez">Entrez PubMed</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=5946628">5946628</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="Voci_correlate">Voci correlate</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&veaction=edit&section=11" title="Modifica la sezione Voci correlate" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=edit&section=11" title="Edit section's source code: Voci correlate"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Polimerasi" title="Polimerasi">Polimerasi</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="Altri_progetti">Altri progetti</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&veaction=edit&section=12" title="Modifica la sezione Altri progetti" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&action=edit&section=12" title="Edit section's source code: Altri progetti"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <div id="interProject" class="toccolours" style="display: none; clear: both; margin-top: 2em"><p id="sisterProjects" style="background-color: #efefef; color: black; font-weight: bold; margin: 0"><span>Altri progetti</span></p><ul title="Collegamenti verso gli altri progetti Wikimedia"> <li class="" title=""><span class="plainlinks" title="commons:Category:DNA polymerases"><a class="external text" href="https://commons.wikimedia.org/wiki/Category:DNA_polymerases?uselang=it">Wikimedia Commons</a></span></li></ul></div> <ul><li><span typeof="mw:File"><a href="https://commons.wikimedia.org/wiki/?uselang=it" title="Collabora a Wikimedia Commons"><img alt="Collabora a Wikimedia Commons" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/18px-Commons-logo.svg.png" decoding="async" width="18" height="24" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/27px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/36px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></a></span> <span class="plainlinks"><a class="external text" href="https://commons.wikimedia.org/wiki/?uselang=it">Wikimedia Commons</a></span> contiene immagini o altri file su <b><span class="plainlinks"><a class="external text" href="https://commons.wikimedia.org/wiki/Category:DNA_polymerases?uselang=it">DNA polimerasi</a></span></b></li></ul> <div class="noprint" style="width:100%; padding: 3px 0; display: flex; flex-wrap: wrap; row-gap: 4px; column-gap: 8px; box-sizing: border-box;"><div style="flex-grow: 1"><style data-mw-deduplicate="TemplateStyles:r140555418">.mw-parser-output .itwiki-template-occhiello{width:100%;line-height:25px;border:1px solid #CCF;background-color:#F0EEFF;box-sizing:border-box}.mw-parser-output .itwiki-template-occhiello-progetto{background-color:#FAFAFA}@media screen{html.skin-theme-clientpref-night .mw-parser-output .itwiki-template-occhiello{background-color:#202122;border-color:#54595D}html.skin-theme-clientpref-night .mw-parser-output .itwiki-template-occhiello-progetto{background-color:#282929}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .itwiki-template-occhiello{background-color:#202122;border-color:#54595D}html.skin-theme-clientpref-os .mw-parser-output .itwiki-template-occhiello-progetto{background-color:#282929}}</style><div class="itwiki-template-occhiello"><span class="noviewer" typeof="mw:File"><a href="/wiki/File:DNA.png" class="mw-file-description" title="Biologia"><img alt=" " src="//upload.wikimedia.org/wikipedia/commons/thumb/4/47/DNA.png/24px-DNA.png" decoding="async" width="24" height="25" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/47/DNA.png/36px-DNA.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/47/DNA.png/47px-DNA.png 2x" data-file-width="298" data-file-height="314" /></a></span> <b><a href="/wiki/Portale:Biologia" title="Portale:Biologia">Portale Biologia</a></b>: accedi alle voci di Wikipedia che trattano di biologia</div></div></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Estratto da "<a dir="ltr" href="https://it.wikipedia.org/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&oldid=141865276">https://it.wikipedia.org/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&oldid=141865276</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Categoria:Categorie" title="Categoria:Categorie">Categoria</a>: <ul><li><a href="/wiki/Categoria:EC_2.7.7" title="Categoria:EC 2.7.7">EC 2.7.7</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Categoria nascosta: <ul><li><a href="/wiki/Categoria:P591_letta_da_Wikidata" title="Categoria:P591 letta da Wikidata">P591 letta da Wikidata</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> Questa pagina è stata modificata per l'ultima volta il 30 ott 2024 alle 09:37.</li> <li id="footer-info-copyright">Il testo è disponibile secondo la <a rel="nofollow" class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.it">licenza Creative Commons Attribuzione-Condividi allo stesso modo</a>; possono applicarsi condizioni ulteriori. Vedi le <a class="external text" href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Terms_of_Use/it">condizioni d'uso</a> per i dettagli.</li> </ul> <ul id="footer-places"> <li id="footer-places-privacy"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy/it">Informativa sulla privacy</a></li> <li id="footer-places-about"><a href="/wiki/Wikipedia:Sala_stampa/Wikipedia">Informazioni su Wikipedia</a></li> <li id="footer-places-disclaimers"><a href="/wiki/Wikipedia:Avvertenze_generali">Avvertenze</a></li> <li id="footer-places-wm-codeofconduct"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Universal_Code_of_Conduct">Codice di condotta</a></li> <li id="footer-places-developers"><a href="https://developer.wikimedia.org">Sviluppatori</a></li> <li id="footer-places-statslink"><a href="https://stats.wikimedia.org/#/it.wikipedia.org">Statistiche</a></li> <li id="footer-places-cookiestatement"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Cookie_statement">Dichiarazione sui cookie</a></li> <li id="footer-places-mobileview"><a href="//it.m.wikipedia.org/w/index.php?title=DNA_polimerasi_(DNA-dipendente)&mobileaction=toggle_view_mobile" class="noprint stopMobileRedirectToggle">Versione mobile</a></li> </ul> <ul id="footer-icons" class="noprint"> <li id="footer-copyrightico"><a href="https://wikimediafoundation.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/static/images/footer/wikimedia-button.svg" width="84" height="29" alt="Wikimedia Foundation" loading="lazy"></a></li> <li id="footer-poweredbyico"><a href="https://www.mediawiki.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/w/resources/assets/poweredby_mediawiki.svg" alt="Powered by MediaWiki" width="88" height="31" loading="lazy"></a></li> </ul> </footer> </div> </div> </div> <div class="vector-settings" id="p-dock-bottom"> <ul></ul> </div><script>(RLQ=window.RLQ||[]).push(function(){mw.config.set({"wgHostname":"mw-web.codfw.main-57488d5c7d-z5nsk","wgBackendResponseTime":153,"wgPageParseReport":{"limitreport":{"cputime":"0.136","walltime":"0.462","ppvisitednodes":{"value":741,"limit":1000000},"postexpandincludesize":{"value":12883,"limit":2097152},"templateargumentsize":{"value":1445,"limit":2097152},"expansiondepth":{"value":12,"limit":100},"expensivefunctioncount":{"value":2,"limit":500},"unstrip-depth":{"value":0,"limit":20},"unstrip-size":{"value":1869,"limit":5000000},"entityaccesscount":{"value":2,"limit":400},"timingprofile":["100.00% 186.187 1 -total"," 45.77% 85.213 1 Template:Enzybox"," 38.41% 71.506 1 Template:Infobox"," 25.52% 47.520 5 Template:Wikidata"," 25.32% 47.136 1 Template:Portale"," 17.64% 32.836 1 Template:Nota_disambigua"," 13.83% 25.743 1 Template:Avviso_permanente"," 7.88% 14.666 1 Template:Interprogetto"," 7.76% 14.456 1 Template:Str_find"," 7.45% 13.865 1 Template:Icona_argomento"]},"scribunto":{"limitreport-timeusage":{"value":"0.060","limit":"10.000"},"limitreport-memusage":{"value":2438767,"limit":52428800}},"cachereport":{"origin":"mw-web.eqiad.main-5675794fcf-qwh88","timestamp":"20241125151214","ttl":2592000,"transientcontent":false}}});});</script> <script type="application/ld+json">{"@context":"https:\/\/schema.org","@type":"Article","name":"DNA polimerasi (DNA-dipendente)","url":"https:\/\/it.wikipedia.org\/wiki\/DNA_polimerasi_(DNA-dipendente)","sameAs":"http:\/\/www.wikidata.org\/entity\/Q206286","mainEntity":"http:\/\/www.wikidata.org\/entity\/Q206286","author":{"@type":"Organization","name":"Contributori ai progetti Wikimedia"},"publisher":{"@type":"Organization","name":"Wikimedia Foundation, Inc.","logo":{"@type":"ImageObject","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-hor-googpub.png"}},"datePublished":"2005-05-31T14:59:11Z","dateModified":"2024-10-30T08:37:17Z","image":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/9\/90\/DNA_polymerase.png","headline":"enzima"}</script> </body> </html>