Levels of a novel metabolic marker, spexin in patients with hirsutism: metabolic syndrome risk in idiopathic and polycystic ovarian syndrome (PCOS) hirsutism | Atakul

<!DOCTYPE html> <head lang="en"> <meta http-equiv="content-type" content="text/html;charset=UTF-8"/> <meta name="viewport" content="height=device-height,width=device-width,initial-scale=1,user-scalable=no"/> <title>Levels of a novel metabolic marker, spexin in patients with hirsutism: metabolic syndrome risk in idiopathic and polycystic ovarian syndrome (PCOS) hirsutism | Atakul | Ginekologia Polska</title> <meta name="description" content=""/> <meta name="gs_meta_revision" content="1.1" /> <meta name="citation_journal_title" content="Ginekologia Polska"/> <meta name="citation_issn" content="2543-6767"/> <meta name="citation_author" content="Nil Atakul"/> <meta name="citation_author_institution" content="Department of Gynecology and Obstetrics, Teaching and Research Hospital, Istanbul, Türkiye"/> <meta name="citation_author" content="Berna Sermin Kılıc"/> <meta name="citation_author_institution" content="Department of Gynecology and Obstetrics, Teaching and Research Hospital, Istanbul, Türkiye"/> <meta name="citation_author" content="Sahabettin Selek"/> <meta name="citation_author_institution" content="Department of Medical Biochemistry, Bezmialem Vakıf University Faculty of Medicine, Istanbul, Türkiye"/> <meta name="citation_author" content="Yildiz Atamer"/> <meta name="citation_author_institution" content="Department of Medical Biochemistry, Beykent University, Faculty of Medicine, Istanbul, Türkiye"/> <meta name="citation_title" content="Levels of a novel metabolic marker, spexin in patients with hirsutism: metabolic syndrome risk in idiopathic and polycystic ovarian syndrome (PCOS) hirsutism"/> <meta name="citation_online_date" content="2024/07/24"/> <meta name="citation_publication_date" content="2024"/> <meta name="citation_volume" content="95"/> <meta name="citation_issue" content="10"/> <meta name="citation_firstpage" content="785"/> <meta name="citation_lastpage" content="790"/> <meta name="citation_doi" content="10.5603/gpl.96191"/> <meta name="citation_abstract_html_url" content="https://journals.viamedica.pl/ginekologia_polska/article/view/96191"/> <meta name="citation_language" content="en"/> <meta name="citation_keywords" xml:lang="en" content="polycystic ovary syndrome (PCOS)"/> <meta name="citation_keywords" xml:lang="en" content="spexin"/> <meta name="citation_keywords" xml:lang="en" content="hirsutism"/> <meta name="citation_keywords" xml:lang="en" content="idiopathic hirsutism (IH)"/> <meta name="citation_pdf_url" content="https://journals.viamedica.pl/ginekologia_polska/article/download/96191/78594"/> <link rel="schema.DC" href="http://purl.org/dc/elements/1.1/" /> <meta name="DC.Creator.PersonalName" content="Nil Atakul"/> <meta name="DC.Creator.PersonalName" content="Berna Sermin Kılıc"/> <meta name="DC.Creator.PersonalName" content="Sahabettin Selek"/> <meta name="DC.Creator.PersonalName" content="Yildiz Atamer"/> <meta name="DC.Date.created" scheme="ISO8601" content="2024-07-24"/> <meta name="DC.Date.dateSubmitted" scheme="ISO8601" content="2023-06-29"/> <meta name="DC.Date.issued" scheme="ISO8601" content="2024-10-31"/> <meta name="DC.Date.modified" scheme="ISO8601" content="2024-10-31"/> <meta name="DC.Description" xml:lang="en" content=" Objectives: Polycystic ovarian syndrome (PCOS) disease the most common endocrinopathy among reproductive age women , and its association with metabolic syndrome is investigated in many reports. The most common cause of hirsutism worldwide is considered to be idiopathic hirsutism (IH) defined as clinical hirsutism without underlying hormonal imbalance. Spexin is a novel peptide and is mainly involved in energy homeostasis and, has not yet made its way into clinical practice. We aim to investigate spexin in an understudied population of hirsute patients. Material and methods: This prospective case-control study analysis involved 48 patients with hirsutism.and, was further divided into two groups: 26 had PCOS syndrome and 22 had IH. 40 healthy, age and BMI-matched non-hirsute women enrolled as the control group. The spexin level was determined using a human spexin ELISA kit. Results: There was no statistically significant difference in spexin levels found between hirsutism and control patients 1514 vs 1425 ng/L, (p = 0.849). Spexin levels were found to be significantly higher in the PCOS hirsutism group than in the IH group (1668.5 ng/L vs 1021 ng/L), (p = 0.022). Correlations of spexin levels with total testosterone, low-density lipoprotein, and total cholesterol were found in hirsutism patients. Conclusions: Our findings conclude that both IH and PCOS hirsutism patients have an increased risk of metabolic syndrome; hyperandrogenemia and dyslipidemia contribute to the progression of upcoming research on metabolic syndrome. Low spexin levels in IH in hirsute patients Could potentially elucidate the pathogenesis of the condition, consequently assisting in diminishing the risk of associated complications. "/> <meta name="DC.Format" scheme="IMT" content="application/pdf"/> <meta name="DC.Identifier" content="96191"/> <meta name="DC.Identifier.pageNumber" content="785-790"/> <meta name="DC.Identifier.DOI" content="10.5603/gpl.96191"/> <meta name="DC.Identifier.URI" content="https://journals.viamedica.pl/ginekologia_polska/article/view/96191"/> <meta name="DC.Language" scheme="ISO639-1" content="en"/> <meta name="DC.Rights" content=" By sending the manuscript with figures and charts Authors declare it has been neither published nor submitted for publication elsewhere (excluding abstracts of 250 words or less). Figures or tables that have been published elsewhere must be identified, and written permission of the original copyright owner must be provided. Such responsibility lies entirely with the Authors and PGS and its Publisher will not be liable for violation of anyone’s copyright or other rights by the authors. 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"/> <meta name="DC.Source" content="Ginekologia Polska"/> <meta name="DC.Source.ISSN" content="2543-6767"/> <meta name="DC.Source.Issue" content="10"/> <meta name="DC.Source.URI" content="https://journals.viamedica.pl/ginekologia_polska"/> <meta name="DC.Source.Volume" content="95"/> <meta name="DC.Subject" xml:lang="en" content="polycystic ovary syndrome (PCOS)"/> <meta name="DC.Subject" xml:lang="en" content="spexin"/> <meta name="DC.Subject" xml:lang="en" content="hirsutism"/> <meta name="DC.Subject" xml:lang="en" content="idiopathic hirsutism (IH)"/> <meta name="DC.Title" content="Levels of a novel metabolic marker, spexin in patients with hirsutism: metabolic syndrome risk in idiopathic and polycystic ovarian syndrome (PCOS) hirsutism"/> <meta name="DC.Type" content="Text.Serial.Journal"/> <meta name="DC.Type.articleType" content="ORIGINAL PAPERS Gynecology"/> <meta name="keywords" content=""/> <meta name="generator" content=" 2.3.6.0"/> <meta name="viewport" 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flex-direction: column; width: 100%; } </style> </div></div><div class="block leftColumnDyn"><div class="blockContent"><span></span></div></div></div></div> </div> <div class="col-xl-9 col-lg-8 col-12 mainColumn"> <div class="block mainColumn"><div class="blockContent"><div class="mainContent"> </div></div></div> <div class="blockContent"> <script> var ArticleCitationDataFiles2 = { id: '96191', authors: '[{\"firstName\":\"Nil\",\"middleName\":\"\",\"lastName\":\"Atakul\",\"affililiations\":[{\"userCanEdit\":false,\"_data\":{\"id\":\"66985\",\"creator_id\":\"44020\",\"country\":\"TR\",\"address\":{\"en_US\":\"\"},\"city\":{\"en_US\":\"Istanbul\"},\"organization\":{\"en_US\":\"Department of Gynecology and Obstetrics, Teaching and Research 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Istanbul\",\"pl_PL\":\"\"},\"postalCode\":{\"en_US\":\"\",\"pl_PL\":\"\"}},\"_metadataAdapters\":[]}]},{\"firstName\":\"Yildiz\",\"middleName\":\"\",\"lastName\":\"Atamer\",\"affililiations\":[{\"userCanEdit\":false,\"_data\":{\"id\":\"66986\",\"creator_id\":\"44020\",\"country\":\"TR\",\"address\":{\"en_US\":\"\"},\"city\":{\"en_US\":\"Istanbul\"},\"organization\":{\"en_US\":\"Department of Medical Biochemistry, Beykent University, Faculty of Medicine\"},\"postalCode\":{\"en_US\":\"\"}},\"_metadataAdapters\":[]}]}]', doi: "{}", title: "Levels of a novel metabolic marker, spexin in patients with hirsutism: metabolic syndrome risk in idiopathic and polycystic ovarian syndrome (PCOS) hirsutism", language: "en", journal: "Ginekologia Polska", pages: "[\"785\",\"790\"]", keywords: "[\"polycystic ovary syndrome (PCOS)\",\"spexin\",\"hirsutism\",\"idiopathic hirsutism (IH)\"]", abstract: "Objectives: Polycystic ovarian syndrome (PCOS) disease the most common endocrinopathy among reproductive age women , and its association with metabolic syndrome is investigated in many reports. The most common cause of hirsutism worldwide is considered to be idiopathic hirsutism (IH) defined as clinical hirsutism without underlying hormonal imbalance. Spexin is a novel peptide and is mainly involved in energy homeostasis and, has not yet made its way into clinical practice. We aim to investigate spexin in an understudied population of hirsute patients. Material and methods: This prospective case-control study analysis involved 48 patients with hirsutism.and, was further divided into two groups: 26 had PCOS syndrome and 22 had IH. 40 healthy, age and BMI-matched non-hirsute women enrolled as the control group. The spexin level was determined using a human spexin ELISA kit. Results: There was no statistically significant difference in spexin levels found between hirsutism and control patients 1514 vs 1425 ng/L, (p = 0.849). Spexin levels were found to be significantly higher in the PCOS hirsutism group than in the IH group (1668.5 ng/L vs 1021 ng/L), (p = 0.022). Correlations of spexin levels with total testosterone, low-density lipoprotein, and total cholesterol were found in hirsutism patients. Conclusions: Our findings conclude that both IH and PCOS hirsutism patients have an increased risk of metabolic syndrome; hyperandrogenemia and dyslipidemia contribute to the progression of upcoming research on metabolic syndrome. Low spexin levels in IH in hirsute patients Could potentially elucidate the pathogenesis of the condition, consequently assisting in diminishing the risk of associated complications.", volume: "95", number: "10", year: "2024", datePublished: "2024-07-24", url: "https://journals.viamedica.pl/ginekologia_polska/article/view/96191", doiurl: "https://doi.org/10.5603/gpl.96191", issn: "{\"print\":\"0017-0011\",\"online\":\"2543-6767\"}", publisher: "VM Media Group sp. z o.o., Grupa Via Medica", }; </script> <div> <div class="articleLandingPage"> <div class="articleTitle"> <h3>Levels of a novel metabolic marker, spexin in patients with hirsutism: metabolic syndrome risk in idiopathic and polycystic ovarian syndrome (PCOS) hirsutism</h3> </div> <div class="authors"> <span data-id="543736"><span class="author-name">Nil Atakul</span><sup title="Department of Gynecology and Obstetrics, Teaching and Research Hospital, Istanbul, Türkiye">1</sup><a class="orcid-link" data-orcid-id="0000-0003-3874-8797" target="_blank" href="https://orcid.org/0000-0003-3874-8797"><img src="/images/orcid.png" /></a></span>, <span data-id="543737"><span class="author-name">Berna Sermin Kılıc</span><sup title="Department of Gynecology and Obstetrics, Teaching and Research Hospital, Istanbul, Türkiye">1</sup><a class="orcid-link" data-orcid-id="0000-0002-0103-0709" target="_blank" href="https://orcid.org/0000-0002-0103-0709"><img src="/images/orcid.png" /></a></span>, <span data-id="543738"><span class="author-name">Sahabettin Selek</span><sup title="Department of Medical Biochemistry, Bezmialem Vakıf University Faculty of Medicine, Istanbul, Türkiye">2</sup><a class="orcid-link" data-orcid-id="0000-0003-1235-3957" target="_blank" href="https://orcid.org/0000-0003-1235-3957"><img src="/images/orcid.png" /></a></span>, <span data-id="543739"><span class="author-name">Yildiz Atamer</span><sup title="Department of Medical Biochemistry, Beykent University, Faculty of Medicine, Istanbul, Türkiye">3</sup></span> </div> <script> $('.authors > [data-id]').each(function() { var $span = $(this); var authorId = $(this).attr("data-id"); var $a = $('<a href="#author-id-' + authorId + '"></a>') .insertBefore($span).append($span); $a.click(function() { var $authorBox = $('<div class="authorBox"></div>'); var $authorName = $('<h4 class="author-name"></h4>').appendTo($authorBox); $authorName.html($span.find(".author-name").html()); if ($span.find(".orcid-link").length) { var $orcid = $span.find(".orcid-link"); $orcid.clone().appendTo($authorBox).append($('<span class="orcid-id">' + $orcid.attr("data-orcid-id") + '</span>')); } $span.find("sup").each(function() { var $affiliation = $(this); $('<div class="author-affiliation">' + $affiliation.attr("title").trim() + '</div>').appendTo($authorBox); }); new _v.tooltips.tooltip($a, $authorBox, {class: 'affiliationInBox', positionParams: {offsetTop: 10}}); return false; }); }); </script> <div class="articleParameters"> <div class="doi"> <span>DOI:</span> <a href="https://doi.org/10.5603/gpl.96191">10.5603/gpl.96191</a> </div> <div class="doi"> <span>Pubmed:</span> <a href="https://www.ncbi.nlm.nih.gov/pubmed/39140353" target="_blank" style="padding: 0px; display: inline">39140353</a> </div> <div class="bibRecords"> Ginekol Pol 2024;95(10):785-790. </div> </div> <div class="articleAbstract"> <h4>Abstract</h4> <div class="articleAbstractText"> <p><strong>Objectives:</strong> Polycystic ovarian syndrome (PCOS) disease the most common endocrinopathy among reproductive age women , and its association with metabolic syndrome is investigated in many reports. The most common cause of hirsutism worldwide is considered to be idiopathic hirsutism (IH) defined as clinical hirsutism without underlying hormonal imbalance. Spexin is a novel peptide and is mainly involved in energy homeostasis and, has not yet made its way into clinical practice. We aim to investigate spexin in an understudied population of hirsute patients. <strong>Material and methods:</strong> This prospective case-control study analysis involved 48 patients with hirsutism.and, was further divided into two groups: 26 had PCOS syndrome and 22 had IH. 40 healthy, age and BMI-matched non-hirsute women enrolled as the control group. The spexin level was determined using a human spexin ELISA kit. <strong>Results: </strong>There was no statistically significant difference in spexin levels found between hirsutism and control patients 1514 vs 1425 ng/L, (p = 0.849). Spexin levels were found to be significantly higher in the PCOS hirsutism group than in the IH group (1668.5 ng/L vs 1021 ng/L), (p = 0.022). Correlations of spexin levels with total testosterone, low-density lipoprotein, and total cholesterol were found in hirsutism patients. <strong>Conclusions: </strong>Our findings conclude that both IH and PCOS hirsutism patients have an increased risk of metabolic syndrome; hyperandrogenemia and dyslipidemia contribute to the progression of upcoming research on metabolic syndrome. Low spexin levels in IH in hirsute patients Could potentially elucidate the pathogenesis of the condition, consequently assisting in diminishing the risk of associated complications.</p> <div class='articleKeywords'> <p> <span class="keywordsLabel strong">Keywords: </span> <span class="subject">polycystic ovary syndrome (PCOS)</span><span class="subject">spexin</span><span class="subject">hirsutism</span><span class="subject">idiopathic hirsutism (IH)</span> </p> </div> </div> </div> <div class="block otherGalleysInline"><div class="blockContent"> <div class="otherGalleys"> <h2>Article available in PDF format</h2> <a class="access icon" data-mini-label="PDF" data-mini-icon="view" href="https://journals.viamedica.pl/ginekologia_polska/article/view/96191/78594" class="file" target="_parent"> View PDF </a> <a class="access icon" data-mini-label="PDF" data-mini-icon="download" href="https://journals.viamedica.pl/ginekologia_polska/article/download/96191/78594" class="file" target="_parent"> Download PDF file </a> </div> </div></div> <div class="articleCitations" id="articleCitations"> <h4 class="articleCitationsTitle"> References</h4> <div class="articleCitationsText"> <ol> <li>Aswini R, Jayapalan S. 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