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class="hero__content"> <h1>E-Books</h1> </div> </div> </div> <main class="wp-block-group main main--page is-layout-flow wp-block-group-is-layout-flow"> <div class="wp-block-group main__content is-layout-constrained wp-block-group-is-layout-constrained"> <div id="ez-toc-container" class="ez-toc-v2_0_69_1 counter-flat ez-toc-counter ez-toc-grey ez-toc-container-direction"> <div class="ez-toc-title-container"> <p class="ez-toc-title" style="cursor:inherit">Table of Contents</p> <span class="ez-toc-title-toggle"></span></div> <nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-1" href="#In_vitro_Metabolism" title="In vitro Metabolism">In vitro Metabolism</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-2" href="#Drug-drug_Interactions" title="Drug-drug Interactions">Drug-drug Interactions</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-3" href="#In_vitro_Toxicology" title="In vitro Toxicology">In vitro Toxicology</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-4" href="#In_vivo_Pharmacokinetics" title="In vivo Pharmacokinetics">In vivo Pharmacokinetics</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-5" href="#Permeability_and_Transporters" title="Permeability and Transporters">Permeability and Transporters</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-6" href="#In_vivo_Safety_Metabolism" title="In vivo Safety Metabolism">In vivo Safety Metabolism</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-7" href="#Preclinical_Characterization_of_Biologics_part_1" title="Preclinical Characterization of Biologics part 1">Preclinical Characterization of Biologics part 1</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-8" href="#Preclinical_Characterization_of_Biologics_part_2" title="Preclinical Characterization of Biologics part 2">Preclinical Characterization of Biologics part 2</a></li></ul></nav></div> <div class="entry-content wp-block-post-content is-layout-flow wp-block-post-content-is-layout-flow"> <figure class="wp-block-image size-large is-resized"><img decoding="async" src="https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-In-vitro-Metabolism-2-724x1024.jpg" alt="" class="wp-image-2683" width="171" height="242" srcset="https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-In-vitro-Metabolism-2-724x1024.jpg 724w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-In-vitro-Metabolism-2-212x300.jpg 212w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-In-vitro-Metabolism-2-768x1087.jpg 768w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-In-vitro-Metabolism-2.jpg 800w" sizes="(max-width: 171px) 100vw, 171px" /></figure> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <h2 class="downloads__title"><span class="ez-toc-section" id="In_vitro_Metabolism"></span>In vitro Metabolism <span class="ez-toc-section-end"></span></h2> <p>The aim of the first e-book in our ADME-Tox e-book series is to help readers understand the importance of ADME studies in drug discovery and development, and to shed light more closely on drug metabolism studies. In the pages of this book, you will learn the key ideas and concepts needed to conduct in vitro metabolism studies in a high-quality manner. Normally for a drug candidate to reach clinical research phase, a series of compounds must be subjected to a battery of in vitro and in vivo tests to weed out the ones with poor pharmacokinetic / pharmacological qualities. This book covers the most essential in vitro metabolism studies, such as metabolic stability and metabolite profiling & identification, and even goes into detail about chemically reactive metabolite characterisation. In addition to incubation conditions for these studies, the most applied analytical methods are also discussed in detail, and instructions are given on how to use the data from in vitro studies to predict in vivo pharmacokinetics.</p> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-In-vitro-Metabolism-e-book.pdf" name="download" data-filetitle="Admescope In vitro Metabolism e-book" data-filename="Admescope-In-vitro-Metabolism-e-book.pdf" data-download="5335" name="download-file" type="checkbox"> <label for="download-file-Admescope-In-vitro-Metabolism-e-book.pdf"> Admescope In vitro Metabolism e-book <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <figure class="wp-block-image size-large is-resized"><img decoding="async" src="https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-in-vitro-Drug-Interactions--724x1024.jpg" alt="" class="wp-image-2685" width="171" height="242" srcset="https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-in-vitro-Drug-Interactions--724x1024.jpg 724w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-in-vitro-Drug-Interactions--212x300.jpg 212w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-in-vitro-Drug-Interactions--768x1087.jpg 768w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-in-vitro-Drug-Interactions-.jpg 800w" sizes="(max-width: 171px) 100vw, 171px" /></figure> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <h2 class="downloads__title"><span class="ez-toc-section" id="Drug-drug_Interactions"></span>Drug-drug Interactions<span class="ez-toc-section-end"></span></h2> <p>The second book in our e-book series introduces us to the inevitable by-product of polypharmacy; drug-drug interactions (DDI), which can be divided into pharmacokinetic and pharmacodynamic interactions. As the emphasis on current regulatory guidance is on pharmacokinetic interactions and more precisely on metabolic interactions, the book focuses on enzyme inhibition and induction studies. It is important to understand the underlying mechanics and differences between enzyme inhibition subtypes, to be able to set up proper incubation methods and to interpret the results correctly. Therefore, this book gives an overview on inhibition kinetics alongside a comparison between the enzyme sources most often used in CYP inhibition studies. Enzyme induction is addressed in the book from CYP point-of-view as CYP induction is the most studied form of induction in drug metabolism and is required by regulatory authorities. The book also covers in vitro to in vivo extrapolation of CYP inhibition and induction, and familiarises readers to different types of models used for DDI prediction.</p> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-In-vitro-Drug-Interactions-e-book.pdf" name="download" data-filetitle="Admescope In vitro Drug Interactions e-book" data-filename="Admescope-In-vitro-Drug-Interactions-e-book.pdf" data-download="5334" name="download-file" type="checkbox"> <label for="download-file-Admescope-In-vitro-Drug-Interactions-e-book.pdf"> Admescope In vitro Drug Interactions e-book <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <figure class="wp-block-image size-large is-resized"><img decoding="async" src="https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-e-book-in-vitro-Tox-724x1024.jpg" alt="" class="wp-image-2689" width="171" height="242" srcset="https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-e-book-in-vitro-Tox-724x1024.jpg 724w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-e-book-in-vitro-Tox-212x300.jpg 212w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-e-book-in-vitro-Tox-768x1087.jpg 768w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-e-book-in-vitro-Tox.jpg 800w" sizes="(max-width: 171px) 100vw, 171px" /></figure> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <h2 class="downloads__title"><span class="ez-toc-section" id="In_vitro_Toxicology"></span>In vitro Toxicology<span class="ez-toc-section-end"></span></h2> <p>Drug-induced toxicity is one of the major reasons for discontinuation of drug development projects or even drug withdrawals. Terminating a drug development project due to toxicity in later phases is expensive and to avoid late-phase project failures, several in vitro toxicology screening tests can be conducted already in the drug discovery phase. Our third e-book in the series introduces readers to the most common forms of toxicity encountered in drug discovery and development, such as, hepatotoxicity, cardiotoxicity and genotoxicity, and what screening tests can be used for each type. These tests include cell viability & cell death assays for cytotoxicity, hERG Predictor assay for cardiotoxicity and AMES assay and micronucleus test for genotoxicity. The book also gives a brief overview of other forms of toxicity; steatosis, phospholipidosis and cholestasis. In addition, the book also takes a glance at exploratory toxicity models which have been developed to address the limitations faced with traditional in vitro assays.</p> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-In-vitro-Toxicology-e-book.pdf" name="download" data-filetitle="Admescope In vitro Toxicology e-book" data-filename="Admescope-In-vitro-Toxicology-e-book.pdf" data-download="5338" name="download-file" type="checkbox"> <label for="download-file-Admescope-In-vitro-Toxicology-e-book.pdf"> Admescope In vitro Toxicology e-book <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <figure class="wp-block-image size-large is-resized"><img loading="lazy" decoding="async" src="https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-e-book-1-in-vivo-DMPK-724x1024.jpg" alt="" class="wp-image-2691" width="171" height="242" srcset="https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-e-book-1-in-vivo-DMPK-724x1024.jpg 724w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-e-book-1-in-vivo-DMPK-212x300.jpg 212w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-e-book-1-in-vivo-DMPK-768x1087.jpg 768w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-e-book-1-in-vivo-DMPK.jpg 800w" sizes="auto, (max-width: 171px) 100vw, 171px" /></figure> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <form class="downloads"> <ul> </ul> </form> </div> </section> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <h2 class="downloads__title"><span class="ez-toc-section" id="In_vivo_Pharmacokinetics"></span>In vivo Pharmacokinetics<span class="ez-toc-section-end"></span></h2> <p>Prior to clinical trials, new drug molecules are examined and tested using in silico and in vitro approaches to weed out the ones with unwanted characteristics, such as low efficacy, toxicity or problematic pharmacokinetics. Even though the development of these approaches has progressed enormously in the last few years, they are still not advanced enough to replace in vivo animal studies. This e-book explains the rationale of performing in vivo pharmacokinetic studies and describes common experimental set-ups supporting drug development. The aim of these studies is usually to evaluate whether the drug candidate can be absorbed via oral administration (bioavailability) or to determine other pharmacokinetic parameters, such as, clearance, half-life, volume of distribution, etc. These parameters can be used, e.g., for comparison of compounds for selecting a lead candidate, or for predicting safe starting dose in clinical trials. Not even perfectly planned and performed in vivo study is of any use if you can鈥檛 analyse your samples reliably. Therefore, a large part of this book is dedicated for the analytical aspects of biosamples, mainly from LC/MS perspective.</p> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-In-vivo-Pharmacokinetics-e-book.pdf" name="download" data-filetitle="Admescope In vivo Pharmacokinetics e-book" data-filename="Admescope-In-vivo-Pharmacokinetics-e-book.pdf" data-download="5342" name="download-file" type="checkbox"> <label for="download-file-Admescope-In-vivo-Pharmacokinetics-e-book.pdf"> Admescope In vivo Pharmacokinetics e-book <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <figure class="wp-block-image size-large is-resized"><img loading="lazy" decoding="async" src="https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-in-vitro-Permeability-and-Transporters-724x1024.jpg" alt="" class="wp-image-2694" width="171" height="242" srcset="https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-in-vitro-Permeability-and-Transporters-724x1024.jpg 724w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-in-vitro-Permeability-and-Transporters-212x300.jpg 212w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-in-vitro-Permeability-and-Transporters-768x1087.jpg 768w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-in-vitro-Permeability-and-Transporters.jpg 800w" sizes="auto, (max-width: 171px) 100vw, 171px" /></figure> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <h2 class="downloads__title"><span class="ez-toc-section" id="Permeability_and_Transporters"></span>Permeability and Transporters<span class="ez-toc-section-end"></span></h2> <p>Permeability is one of the key factors determining how a drug is absorbed, distributed and eliminated. Most conventional small molecule drugs permeate through cell membranes via passive diffusion or are actively transported by transporter proteins. The function of these drug transporters can be affected by co-administered drugs, and thus transporter studies should be included in drug-drug interaction evaluation. Our fifth e-book explains the fundamental differences between passive drug permeation and active transportation and the clinical relevance of these phenomena. The most relevant drug transporters, divided into efflux and uptake transporters, are listed in the book alongside with brief assay descriptions on how to study their functions for evaluating drug-drug interaction risk. To book also describes how basic permeation studies can be conducted utilising Caco-2 or MDCKII cell monolayers.</p> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-In-vitro-Permeability-and-Transporters-e-book.pdf" name="download" data-filetitle="Admescope In vitro Permeability and Transporters e-book" data-filename="Admescope-In-vitro-Permeability-and-Transporters-e-book.pdf" data-download="5336" name="download-file" type="checkbox"> <label for="download-file-Admescope-In-vitro-Permeability-and-Transporters-e-book.pdf"> Admescope In vitro Permeability and Transporters e-book <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <figure class="wp-block-image size-large is-resized"><img loading="lazy" decoding="async" src="https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-e-book-in-vitro-Safety-Metabolism-724x1024.jpg" alt="" class="wp-image-2697" width="171" height="242" srcset="https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-e-book-in-vitro-Safety-Metabolism-724x1024.jpg 724w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-e-book-in-vitro-Safety-Metabolism-212x300.jpg 212w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-e-book-in-vitro-Safety-Metabolism-768x1087.jpg 768w, https://admescope.com/wp-content/uploads/sites/2/2023/07/Cover-e-book-in-vitro-Safety-Metabolism.jpg 800w" sizes="auto, (max-width: 171px) 100vw, 171px" /></figure> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <h2 class="downloads__title"><span class="ez-toc-section" id="In_vivo_Safety_Metabolism"></span>In vivo Safety Metabolism<span class="ez-toc-section-end"></span></h2> <p>In addition to the safety of the parent drug, the safety of drug metabolites must be demonstrated. The metabolites in safety testing (MIST) concept addresses the questions how to identify potential safety issues caused by drug metabolites and is the topic of our sixth e-book. As the drug metabolites might have toxic effects, a concern arises if the metabolite is present only, or at disproportionately higher levels, in humans than in the animals used in the non-clinical toxicological studies. This e-book introduces the general principles of the safety metabolism work. In addition, why and when the work should be initiated and what should be considered when planning the studies are discussed. The tools to demonstrate the safety of drug metabolites or to identify potential safety issues, such as MIST analysis and radiolabeled metabolite in vivo Met Id and profiling, are covered by the e-book.</p> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-In-vitro-Safety-Metabolism-e-book.pdf" name="download" data-filetitle="Admescope In vitro Safety Metabolism e-book" data-filename="Admescope-In-vitro-Safety-Metabolism-e-book.pdf" data-download="5337" name="download-file" type="checkbox"> <label for="download-file-Admescope-In-vitro-Safety-Metabolism-e-book.pdf"> Admescope In vitro Safety Metabolism e-book <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <figure class="wp-block-image size-large is-resized"><img loading="lazy" decoding="async" src="https://admescope.com/wp-content/uploads/sites/2/2024/09/Admescope-Preclinical-Characterization-of-Biologics-part-1-e-book-cover-724x1024.jpg" alt="" class="wp-image-5356" width="171" height="242" srcset="https://admescope.com/wp-content/uploads/sites/2/2024/09/Admescope-Preclinical-Characterization-of-Biologics-part-1-e-book-cover-724x1024.jpg 724w, https://admescope.com/wp-content/uploads/sites/2/2024/09/Admescope-Preclinical-Characterization-of-Biologics-part-1-e-book-cover-212x300.jpg 212w, https://admescope.com/wp-content/uploads/sites/2/2024/09/Admescope-Preclinical-Characterization-of-Biologics-part-1-e-book-cover-768x1087.jpg 768w, https://admescope.com/wp-content/uploads/sites/2/2024/09/Admescope-Preclinical-Characterization-of-Biologics-part-1-e-book-cover.jpg 800w" sizes="auto, (max-width: 171px) 100vw, 171px" /></figure> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <h2 class="downloads__title"><span class="ez-toc-section" id="Preclinical_Characterization_of_Biologics_part_1"></span>Preclinical Characterization of Biologics part 1<span class="ez-toc-section-end"></span></h2> <p>The previously published e-books were focusing on small molecules. However, during the last decades the number of biologics in drug discovery and development projects has been increasing. The size and complex structure introduces some challenges for the biologics characterisation and similar methodology cannot be typically applied, compared with the small molecules. Comprehensive understanding the molecular structure forms crucial foundation for the development of biologics. The seventh e-book introduces preclinical characterization of biologics to the reader.</p> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-Preclinical-Characterization-of-Biologics-part-1-e-book.pdf" name="download" data-filetitle="Admescope Preclinical Characterization of Biologics part 1 e-book" data-filename="Admescope-Preclinical-Characterization-of-Biologics-part-1-e-book.pdf" data-download="5340" name="download-file" type="checkbox"> <label for="download-file-Admescope-Preclinical-Characterization-of-Biologics-part-1-e-book.pdf"> Admescope Preclinical Characterization of Biologics part 1 e-book <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <figure class="wp-block-image size-large is-resized"><img loading="lazy" decoding="async" src="https://admescope.com/wp-content/uploads/sites/2/2024/09/Admescope-Preclinical-Characterization-of-Biologics-part-2-e-book-cover-1-724x1024.jpg" alt="" class="wp-image-5360" width="171" height="242" srcset="https://admescope.com/wp-content/uploads/sites/2/2024/09/Admescope-Preclinical-Characterization-of-Biologics-part-2-e-book-cover-1-724x1024.jpg 724w, https://admescope.com/wp-content/uploads/sites/2/2024/09/Admescope-Preclinical-Characterization-of-Biologics-part-2-e-book-cover-1-212x300.jpg 212w, https://admescope.com/wp-content/uploads/sites/2/2024/09/Admescope-Preclinical-Characterization-of-Biologics-part-2-e-book-cover-1-768x1087.jpg 768w, https://admescope.com/wp-content/uploads/sites/2/2024/09/Admescope-Preclinical-Characterization-of-Biologics-part-2-e-book-cover-1.jpg 800w" sizes="auto, (max-width: 171px) 100vw, 171px" /></figure> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <h2 class="downloads__title"><span class="ez-toc-section" id="Preclinical_Characterization_of_Biologics_part_2"></span>Preclinical Characterization of Biologics part 2<span class="ez-toc-section-end"></span></h2> <p>Our second biologics e-book focuses on two types of biological drugs: antibody-drug conjugates (ADCs) and oligonucleotides. Both modalities have their own special beneficial characteristics, as well as limitations, from the drug discovery and development point of view. This e-book gives an overview of the pharmacokinetics and preclinical ADME characterization of ADCs and oligos, and of the analytical techniques typically applied.</p> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-Preclinical-Characterization-of-Biologics-part-2-e-book.pdf" name="download" data-filetitle="Admescope Preclinical Characterization of Biologics part 2 e-book" data-filename="Admescope-Preclinical-Characterization-of-Biologics-part-2-e-book.pdf" data-download="5341" name="download-file" type="checkbox"> <label for="download-file-Admescope-Preclinical-Characterization-of-Biologics-part-2-e-book.pdf"> Admescope Preclinical Characterization of Biologics part 2 e-book <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> </div></div> <section class="block block--primary"> <div class="block__content block__content--right"> <div class="block__text"> <h2>Feel free to contact us!</h2> <p><strong>Curious to know more about what can we do for you? 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src="//js-eu1.hs-scripts.com/25214463.js"></script>  </div></div> <section class="downloads__aside" id="sidebar-downloads"> <button class="downloads__label"> <span>0</span> <svg><use xlink:href="#icon-download"></use></svg> </button> <div class="downloads__content"> <button class="downloads__close" id="downloads-close"><svg xmlns:xlink="http://www.w3.org/1999/xlink"><title>Close this panel</title><use xlink:href="#icon-times"></use></svg></button> <div id="selected-files" class="downloads__files"> <h3>Files</h3> <div> <ul></ul> </div> <button style="margin-top:20px;" id="remove-all-files" type="submit" class="button">Remove all</button> </div> <form class="downloads__form form" action="https://admescope.com/wp-admin/admin-ajax.php" method="POST" id="symeresdownloads"> <p>Please, provide us your email address so that we can send you a link for downloading the requested files.</p> <div class="form__row"> <div class="form__col"> <label for="email">Email</label> <input id="email" name="email" type="email" placeholder="Email" required> </div> </div> <div class="form__row"> <div class="form__col"> <label for="agreement"> <input id="agreement" name="agreement" type="checkbox" required> <div>By downloading, I agree to the <a href='/privacy-policy/'>privacy policy</a></div> </label> </div> </div> <div class="form__row"> <div class="form__col"> <input type="text" name="downloaded_files" value="" style="opacity: 0;height: 0;overflow: hidden;"> <button type="submit" class="button button--primary">Download file(s)</button> <input type="hidden" name="action" value="symeresdownloads"> </div> </div> </form> </div> </section><script> jQuery( document ).ready(function() { jQuery(function ($) { let downloads = {}; $('body').on('click', '#downloads-close', function(){ $('.downloads__label').css('display', 'flex'); $('.downloads__content').css('display', 'none'); }); $('body').on('click', '.downloads__label', function(){ $('.downloads__label').css('display', 'none'); $('.downloads__content').css('display', 'flex'); }); $('body').on('change', 'form.downloads', function(){ let downloadsList = ''; let filenames = {}; $('input:checkbox[name=download]').each(function(){ filenames[$(this).data('filename')] = $(this).data('filetitle'); if (this.checked) { downloads[$(this).data('download')] = $(this).data('filename'); } else { if ($(this).data('download') in downloads) { delete downloads[$(this).data('download')]; } if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); if ($(this).data('download') in downloadsFromLocalStorage) { delete downloadsFromLocalStorage[$(this).data('download')]; localStorage.setItem('downloads', JSON.stringify(downloadsFromLocalStorage)); } } } $('input[name="downloaded_files"]').val(Object.values(filenames).join(',')); }); // set filenames + titles in localStorage if (Object.keys(filenames).length) { let filenamesJson = JSON.stringify(filenames); if (localStorage.getItem('filenames')) { let currentFilenames = JSON.parse(localStorage.getItem('filenames')); filenames = { ...currentFilenames, ...filenames }; filenamesJson = JSON.stringify(filenames); } localStorage.setItem('filenames', filenamesJson); } if (Object.keys(downloads).length) { $('.downloads__aside').css('display', 'block'); let downloadsJson = JSON.stringify(downloads); if (localStorage.getItem('downloads')) { let currentDownloads = JSON.parse(localStorage.getItem('downloads')); downloads = { ...currentDownloads, ...downloads }; downloadsJson = JSON.stringify(downloads); } localStorage.setItem('downloads', downloadsJson); } else { if (!localStorage.getItem('downloads')) { localStorage.removeItem('downloads'); } } Object.keys(downloads).forEach(key => { let label = $('.downloads li label[for="download-file-' + downloads[key] + '"]').text(); if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsFromLocalStorage[key] in filenames) { label = filenames[downloadsFromLocalStorage[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsFromLocalStorage[key] + '"]').text(); } } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloads).length); $('#selected-files ul').html(downloadsList); // if (Object.keys(downloads).length) { //if (localStorage.getItem('downloads')) { // $('.downloads__aside').css('display', 'block'); // } else { // $('.downloads__aside').css('display', 'none'); // } }); if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); let downloadsList = ''; $("input[name='downloaded_files']").val(Object.values(downloadsFromLocalStorage).join(',')); Object.keys(downloadsFromLocalStorage).forEach(key => { $(".downloads ul").find("[data-filename='" + downloadsFromLocalStorage[key] + "']").prop('checked', true); let label = ''; if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsFromLocalStorage[key] in filenames) { label = filenames[downloadsFromLocalStorage[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsFromLocalStorage[key] + '"]').text(); } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloadsFromLocalStorage).length); $('#selected-files ul').html(downloadsList); $('.downloads__aside').css('display', 'block'); } else { $('.downloads__aside').css('display', 'none'); } $('body').on('click', '#remove-all-files', function(){ localStorage.removeItem('downloads'); $('#selected-files div ul li').remove(); $('.downloads__aside').css('display', 'none'); location.reload(); }); $('body').on('click', '#selected-files button', function(){ $('form.downloads input[data-download=' + $(this).data('download') + ']').prop('checked', false).trigger('change'); if (localStorage.getItem('downloads')) { let downloadsLocalObj = JSON.parse(localStorage.getItem('downloads')); if ($(this).data('download') in downloadsLocalObj) { delete downloadsLocalObj[$(this).data('download')]; localStorage.setItem('downloads', JSON.stringify(downloadsLocalObj)); //reload sidebar html let downloadsList = ''; Object.keys(downloadsLocalObj).forEach(key => { $(".downloads ul").find("[data-filename='" + downloadsLocalObj[key] + "']").prop('checked', true); let label = ''; if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsLocalObj[key] in filenames) { label = filenames[downloadsLocalObj[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsLocalObj[key] + '"]').text(); } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloadsLocalObj).length); $('#selected-files ul').html(downloadsList); $('.downloads__aside').css('display', 'block'); } } }); $('#symeresdownloads').on('submit', function (e) { e.preventDefault(); if (localStorage.getItem('downloads')) { downloads = JSON.parse(localStorage.getItem('downloads')); $("input[name='downloaded_files']").val(''); $("input[name='downloaded_files']").val(Object.values(downloads).join(',')); } var symeresdownloads = $('#symeresdownloads'); var email = $("#symeresdownloads :input[name='email']").val(); var firstName = $("#symeresdownloads :input[name='first-name']").val(); var lastName = $("#symeresdownloads :input[name='last-name']").val(); var company = $("#symeresdownloads :input[name='company']").val(); var action = $("#symeresdownloads :input[name='action']").val(); downloads['email'] = email; downloads['first-name'] = firstName; downloads['last-name'] = lastName; downloads['company'] = company; downloads['action'] = action; runAjaxCall(symeresdownloads, downloads); // Clean up the downloads object delete downloads['email']; delete downloads['first-name']; delete downloads['last-name']; delete downloads['company']; delete downloads['action']; e.preventDefault(); }); function runAjaxCall(symeresdownloads, downloads) { var array = Object.keys(downloads).map((key) => [String(key), downloads[key]]); $.ajax({ url: symeresdownloads.attr('action'), data: downloads, // form data type: symeresdownloads.attr('method'), // POST beforeSend: function (xhr) { jQuery('#symeresdownloads button').hide(); jQuery('<p class="download-status">Your file(s) are being processed.</p>').insertAfter('#symeresdownloads button'); }, success: function (data) { let error = false; if (data.includes('address') || data.includes('download')) { if (!data.includes('Thank you')) { error = true; jQuery('.download-status').remove(); jQuery('.downloads__content').append('<div class="status-msg" style="font-weight:500; color: #FFF;">' + data + '</div>') } } if (data.includes('Thank you')) { error = false; jQuery('.download-status').remove(); jQuery('.downloads__content').append('<div class="status-msg" style="font-weight:500; color: #FFF;">' + data + '</div>') } setTimeout(function(){ jQuery('.status-msg').remove(); if (error) { jQuery('input#email').css('border-color', '#d63637'); location.reload(); } if (!error) { localStorage.removeItem('downloads'); $('.downloads__aside').css('display', 'none'); location.reload(); } }, 5000); } }); } if ($('.downloads__label span').text() == '0') { $('.downloads__aside').css('display', 'none'); } $('body').on('change', '.downloads__label span', function(){ if ($('.downloads__label span').text() == '0') { $('.downloads__aside').css('display', 'none'); } }); }); }); </script><script id="wp-block-template-skip-link-js-after"> ( function() { var skipLinkTarget = document.querySelector( 'main' ), sibling, skipLinkTargetID, skipLink; // Early exit if a skip-link target can't be located. if ( ! skipLinkTarget ) { return; } /* * Get the site wrapper. * The skip-link will be injected in the beginning of it. */ sibling = document.querySelector( '.wp-site-blocks' ); // Early exit if the root element was not found. if ( ! sibling ) { 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