CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="120"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "publications.waset.org",cType: 'non-interactive',cRay: '9135dbdb7c90d083',cH: 'hUr8NaoabnwESgAie8GmNMDgzQZUz876CtPitvz0oig-1739796161-1.2.1.1-0jy2q8KwxYO5NHDsSQbx89x1y_qT9KkiiQbJ2aA4Du15I_taVaehSukw1W_LfCqk',cUPMDTk: "\/abstracts\/search?q=5-fold%20lower%20dose.&__cf_chl_tk=tnAiCcc8GNOCoL2aN2vXZoS257_.TAJcUx1Pg26dRm0-1739796161-1.0.1.1-fq.TO_23SMNp.Huhq2lcSoqzX0ODT.kyT2xD2uNS0lc",cFPWv: 'b',cITimeS: '1739796161',cTTimeMs: '1000',cMTimeMs: '120000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/abstracts\/search?q=5-fold%20lower%20dose.&__cf_chl_f_tk=tnAiCcc8GNOCoL2aN2vXZoS257_.TAJcUx1Pg26dRm0-1739796161-1.0.1.1-fq.TO_23SMNp.Huhq2lcSoqzX0ODT.kyT2xD2uNS0lc",md: "ugwbweKJAIXYvZvdTa7PcTBVbYgZsUF61bX0Rq5kLek-1739796161-1.2.1.1-QhZiMlL2ftVfM5GnzGs3cfOrxdPJh5UNNRKdjifN_TeEpzcPbA1rzwUOHfKjsir442hnQ57Htxzhq1gt5nKx9bRW3nl2xhHTePrkT8zl.P7uh.WWtzu8gdGFjb5unhU7KSavh7fC4X3NarPEIXf7djG8ixeDTE0XV.plUur8h.NBi21zovLqlW2LgdRSWGH_.RwffSy57ObIeGSE7JV_jcr87O7bOECqom0kAvT6kuCmX.O1Fznpj5Kezvh7jZVtHARTqXJPbQgIfUPbAS9XnALq0supzH2A9U2xZlI22r7Ffoq52JlcyozxXFbk_zoVsDRLFRekOlaKv67SCHTOn6jj5ZWSA3f51LK_Ix4X9hQvY5hKAlZ0djQYGX1SIXZaBtu8_ZTiK_sNWMON2PgqrN4tipN8VcaaA88QAzQLQTPROzMN5hTvkQ0tM500hi2ooilLxvASqu8L_ZpZN9ib4YbdzV6pvvWsQo2_RjOwx_64iXSGjjkFYmn2oJSYpMge1ZJf6UfOaKq.Gcv0NqiWnc3NUbkCh37OsKJu20RRZBD3OmQuxHIBwSL_JdHMr6MogIp1dn3E_PZScOHr88G9ISY_a.tAWqWHoJMjlvT01cVWzB8F4aadvv1UjPb78p4xkTycg6H4SDMrikUbWRAlJuAe0AcyHOOr.9m_0qCuXiPY67bwuR.UvbY51oYiyABtu3q9YYPW0w0yoAEN87xUH49ujNa605lyNN1vGVy2IbAWV9MrKIFoQEJyKmXQXy5PioShVc_ABrcJQxa8xc.JjoKZ8JfHyylUujq0jM2iM2nqIgz6vjArl29j0ZcnlIp6bJUDj1Hrosatku3XK7LwEnasdd2KDYS6IH6uPhzNXwj4ZQAhTVeyDzy8QG8hBB1a9naSx3Q25cF7U2.hqon9Ys48Uscdk3zDYa.lh_NLN6tQHTOwiXOvaScti41jI_vyXrKoiIaSD1WuctUUTCg7Z9be7QozdO4laD2SoK7NRmLTYCWoXJ7YZX6.Xx1o1lwhAYVTuIdC_7u1bA3cO9W8PGNhX6GH56Kl5kZ2sQUEJ_GOs_gBQHOxkoff8TPJ0NrqT6TLALGCk.cOhKbozmqTMrL1I5FQoGmwQz1h9RQRSwUZ42Tfq3hmff2TZkrXqK5AWzta4Ycrl6LOhqQZ4drZEnSzMUWYc6oV2nHLEE.9JcdWFt0ju36qpWcpPRNVo0OPOIK.0KdPUuCuix387rr.bSV7joYyxdSV8pIrLw0630zNN_llCMSvEQ1H1LfTlr7o5jYu4YIbkACFWfSFLdEGKSTxJhWBtq7_1EbKhUmMcM0dLm_cPAlHe9CeMXPW74k13VlKst5djzYHA4zdz6gpOT.JWeTsJYxsWbaPhYRY3lVL1L7Qdc1tS6E2_Pkb4K_wmoTZNK9FkLpuTcGyH45BrCbxC78tW1aCOwzSs8FrgfnxtdshwgaZ8GKBYbZu_9qVUqR6k17HAY_dQGWNM6_MPk0NauIVW5vk2tSr1jCPFN.Zh_SyOtdoqcMZ4OiVcXW8ItszZhMTqMEcCji65ktR7wnmfhlpm6vPvKE.fYaJLJf1C7NJ77itq7PpGndrJMsBaLGdTyHydr3nZ8k_p1aiWNaXiI5.FtcOl3gUbXnHC0Rt3H4srK8RqOx_iZa5xxUg.o4SmHVS3Hy4LwFBgUiBL_6GjhLkB8FizBafUteem__5TRkbGHqPPeiHtGXS12qpxWv9B3mrUGkO3NpioLHQzJCIxyAUl9aBVKarkhVEhx0F5C9encva9c7Owb2WLfT85EwEZd4f6Xoa52mamGGSbANezrNHQd4Ypc9rJNH51ZtMbBvSwFpkZM_u8h6B7wXwn_52rV.hKR_loXhGFtK3i.kRHFPuy71Dx952wsNgmzT5cLIkw9cpVI.M14RqZuQ8KncmhgnCNn4o_PjpKQNGjwqrhkrp2waa760Ofk22biDNBEmgikXe2imuxa_.FNiO",mdrd: "9OR_yfOWMb9Ao.ktLGhB5I5fE1XF8YupbgHX8UZXWGI-1739796161-1.2.1.1-qjy2e05Ol3YN7BhJ6e5GbBPHHuLK5j_xmye5oNMY49ndBjc7MgWC5Q_SxrRmW1xi_UCGu4SrfdGSsEkXQ7ilkiB8H37biTLJXemhAjmHGTa6kbTUEWzxeHhrNfXDty5AVVWKK_bSrI5dHtlZJ7b6Scz.RycgvtuQvdvY51z_1U0lDMguDc7FgmjoJDXJXJN3vF1iVpWC0T0g09ydhCJjyx.Iq45RTT2A1hn8Y3IX8bj3AKYTnPWLYMoQaCIQQjfxlZriBd65uSd0oln2bc2zAk6OXTIIzH5FfP9p_CgFRAUBpi1cddRwtL_xP8Le7VLDXcJdilUiMVEOUhTQopCGo7XVRFLmyosbOhw6nkLRDCBGtvDBg6sHFwhAQ80NmMQJWxYAJF0C92xFomEbW7mau0FRDjxt.lofSriVUAvS4HJxpo4LPZ_xpRtVXCoypP1NEH20gjJVXblWmbrqmxErycXFFSg26qbofHKmVq.hXCyHfxapZ23mCnSZ1w69PidVyfvekxA69DMXAZu5p9H29ULbraSMoQdrc3GWRGuqxQcUQd2txPktxJ0bZOx3KPanJAd0VKJbQ9cKmyln4y5d.Rf7AKpgajYiy3hjnafeTEVh1wptp7QeESsc2JXjLE_N_kc.YGEA9Oirl4F4CL9ouBXlBM5HC1iqNmTctGD0.qOXzG5akmu2Ay4r0LUJ3Oq26ES0VXyNwAJanNN7pqFatAy.lR6edK5zm.3t3JCKRMP_53L2WQEoJB4emM1cNYkaAehAmJOFJmfZLPGlgUtqXHruTJcxOFfYnsG6mrJsm28BEnMwu3hK3W731goh4AKrjWm4gkNAdM2YcOf.m7a3j..obMeJcL10bz0Us4uEZ.Ojhp91EpAoy9fFgyRx.wCXDKpW_qWJF30jI5JfaCSkUpaw9k8J4Pkgf_i7iBikYyhz2dObDXJTuwy4mibG0d6cZCTwILacmfg2I5Ts39t.OLHxXVUMqpf9dmh9BRimcsM1cCEKWO0WZ3kTnEyRL68NEaHFdbLWNgHk0dGPOtoX9LTEh1_Fx__5scinjxz3KWsbkX_5fujOYodcoY6LllKk1foXTOya2lxj5tPS6dsJMlR2yYli.PdEvGoZ.zdi2Z7gQJeHWT5oZgQ76YzKQ6gluOKHnsxuaFQ0SjI5VerSoR.ud5IOlY6ktTwDcZt40V7DMbTFoqOuhCaIe3hVBXcEYy0PiBGyRtwT5Qd2aCNgwwLMd4sguCnxzq2.FxybzzFM5mwZL6SFrX5q0JaM3eEqu_C7gAcjre.jnzJqUkeBrLtds1dUDH9T0ggmqErUhSjtCIfgI_kbNpV.R3un8CUwXbafJT_t_QufeyJ7vDyBddx1y01u0TsRH72Rmk01ZO74fZqGEDtOTl.O5yD3usu4i8PgOxrm0CKQRkSIEh1ofRCfXnh8_XzOYeu0sREbCvsIhSdymPzCIJGpAGlYCTUCsy3GyZ38QgpOv8z4OIRgconqqQxXpdE1JqSLzqKav1BaAM.LJWJG57Sa3aY9ofwyvxAqGUF3f1kMKQJfuHe3Ju.k5zf6e.cuivo5EvlZYhkb6xsV6uF2FOTFzxgte90IxSnKsCFpPGya2pxzZLavshSZWKBWTVC0ENHxQa44lqS1uATNYLcOZMeq23o6U0jGkJ_tTTP4x5InoxPh6zydH4MXKEsGdSZwoE4YUmet4pq9M.fCUOfYplje1O7v9QSVLJJocpIjdc7HtgJe89RqecVh7KABE8Rm4i6A8b2m9JDDm3mq5cO8LJx3ET9p2voxLic5jXhyxIMIfUFyAwoMCOe7qgUvTTlhCCVO7QCAwennZ4c9FJc72wsYz7sLC0yuWQS_g73U4SKWZVUQ63l9Rvm.IeIHT1u.KyIFYR4Yqtg_AtVWVmXAD6RpSSu19zFW5JZlmGqqWiossshFid0v84eGq21NGafueHMvTadKx4gRTQttfBFClzOz2xk968y9"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=9135dbdb7c90d083';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/abstracts\/search?q=5-fold%20lower%20dose.&__cf_chl_rt_tk=tnAiCcc8GNOCoL2aN2vXZoS257_.TAJcUx1Pg26dRm0-1739796161-1.0.1.1-fq.TO_23SMNp.Huhq2lcSoqzX0ODT.kyT2xD2uNS0lc" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>