Breakout Discussions | Immuno-Oncology Summit

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style="display:none;visibility:hidden"></iframe></noscript> <div class="main-content"> <div id="cph1" class="container internal"> <div class="row"> <div class="row" data-sf-element="Row"> <div class="col-sm-9"> <div id="Contentplaceholder1_T39935FB7001_Col00" class="sf_colsIn pad-lr" data-sf-element="Column 1" data-placeholder-label="Column 1"> <div > <div class="sf-Long-text" ><h1 class="page-title">Interactive Breakout Discussions</h1><p>Interactive Breakout Discussions are informal, moderated discussions, allowing participants to exchange ideas and experiences and develop future collaborations around a focused topic. Each discussion will be led by a facilitator who keeps the discussion on track and the group engaged. To get the most out of this format, please come prepared to share examples from your work, be a part of a collective, problem-solving session, and participate in active idea sharing.</p><p class="Date">WEDNESDAY, AUGUST 7, 10:10 AM – 10:55 AM</p><p><b>Breakout Discussions with Networking Coffee Break</b></p><p class="Header" style="text-align:center;"><span class="abstract"></span>TRACK: BISPECIFIC ANTIBODIES FOR CANCER IMMUNOTHERAPY</p><p><b>IN-PERSON BREAKOUT TABLE 1: </b><b>Challenges and Advancements with Bi and Multi-Specific Antibodies</b></p><b></b><p><i>Moderator:  </i><i>Mark A Tornetta, Vice President, Biologics Discovery, Tavotek Biotherapeutics</i></p><b></b><ul><li>Challenges and solutions in bi- and multi-specific antibody design</li><li>CMC considerations for bi- and multi-specifics</li><li>Advancements in solid tumors and future directions</li></ul><p> </p><p style="text-align:center;" class="Header">TRACK: ADVANCES IN CAR T THERAPY</p><b><p><b>IN-PERSON BREAKOUT TABLE 2: </b><b>Precision Tailoring CAR T Therapy</b></p></b><p><i>Moderator:  </i><i>Julia A Coronella, PhD, VP Immuno Oncology, Immuno Oncology, Poseida Therapeutics Inc</i></p><b></b><ul><li>Considerations for TSCM-based CAR T products</li><li>Autologous vs allogenic therapy</li><li>Viral vs non-viral methodologies</li></ul><p> </p><p style="text-align:center;" class="Header">TRACK: THERAPEUTIC CANCER VACCINES</p><b><p><b>IN-PERSON BREAKOUT TABLE 3: </b><b>Therapeutic Cancer Vaccines: Key Areas of Research and Innovation Driving Future Success</b></p></b><p><i>Moderator: </i><i>Marion Curtis, PhD, Assistant Professor, Immunology, Mayo Clinic</i></p><b></b><ul><li>What are the most promising strategies to identify and target tumor-specific antigens using cancer vaccines?</li><li>What are the most effective vaccine delivery platforms for cancer therapy?-</li><li>What role do combination therapies play in overcoming immunosuppression and maximizing the effectiveness of cancer vaccines?</li><li>How can cancer vaccines be successfully integrated into standard of care cancer treatment?</li></ul><b><b><br /></b> <p class="Date">FRIDAY, AUGUST 9, 7:30 AM - 9:00 AM</p><p><b>Breakfast Breakout Discussions</b></p></b><p style="text-align:center;" class="Header">TRACK: EMERGING TECH FOR IO TARGETING & DISCOVERY</p><b><p><b>IN-PERSON BREAKOUT TABLE 4: </b><b>Leveraging Biomarker Technologies for Understanding PD-1 Innate and Adaptive Resistance to Inform New Targets and New Combinations</b></p></b><p><i>Moderator: Theresa M. LaVallee, PhD, Chief Development Officer, Coherus Biosciences</i></p><b></b><ul><li>Approaches to characterize PD-1 resistance</li><li>Applications of PD-1 resistance characterization for target discovery </li><li>Uncovering novel and next-gen combination treatment approaches through PD-1 findings</li></ul><b><p><b style="background-color:transparent;color:inherit;font-size:inherit;text-align:inherit;text-transform:inherit;word-spacing:normal;caret-color:auto;white-space:inherit;">IN-PERSON BREAKOUT TABLE 5: </b><b style="background-color:transparent;color:inherit;font-family:inherit;font-size:inherit;text-align:inherit;text-transform:inherit;word-spacing:normal;caret-color:auto;white-space:inherit;">Next-Gen Tech for Improved IO Outcomes Through TAMs</b><br /></p></b><p><i>Moderator: </i><i>Nir Chetrit, PhD, Associate Researcher, Weill Cornell Medicine</i></p><b></b><ul><li>Modulating the tumor-supporting functions of TAMs: current approaches & challenges</li><li>Novel strategies and technologies to overcome limitations of TAM reprogramming</li><li>Scalable TME models and platforms for high-throughput discovery</li></ul><p> </p><p style="text-align:center;" class="Header">TRACK: EMERGING CELL-BASED IMMUNOTHERAPIES</p><b><p><b>IN-PERSON BREAKOUT TABLE 6: Improving Safety to Expand Patient Eligibility for TIL Cell Therapy</b></p></b><p><i>Moderator: Madan H. Jagasia, MS, Chief Executive Officer, R&D, Obsidian Therapeutics</i></p><b></b><ul type="disc"><li>Currently available non-engineered TIL cell therapy requires use of high-dose IL2, which has well-described high-grade toxicity that limits patient eligibility</li><li>Novel approaches are needed to improve the safety of TIL cell therapy to enable a broader patient population to benefit</li><li>Discussion will focus around existing approaches to improve safety as well as potential avenues to explore in future trials</li></ul><b><p><b>IN-PERSON BREAKOUT TABLE 7: </b><b>NK Cells: Challenges, Breakthroughs, and Future Directions</b></p></b><p><i>Moderator: </i><i>Nicholas A Zorko, PhD, Assistant Professor, Hematology & Oncology & Transplant, University Of Minnesota Twin Cities</i></p><b></b><ul><li>Challenges with NK cell therapy development</li><li>Pros and cons of NK approaches compared to other cell-based therapeutics</li><li>Applications of NK therapies to solid tumor indications</li><li>Future directions of NK therapies</li></ul><p> </p><p style="text-align:center;" class="Header">TRACK: TUMOR MICROENVIRONMENT</p><b><p><b>IN-PERSON BREAKOUT TABLE 8: Immunosuppression in the Tumor Microenvironment</b></p></b><p><i>Moderator: Thierry Guillaudeux, PhD, CSO, Kineta, Inc.</i></p><b></b><ul type="disc"><li>What are the major drivers of immunosuppression in the tumor microenvironment?</li><li>What are the strategies to overcome immunosuppression?</li><li>What are the promising new targets?</li><li>Which combination strategies should be considered to restore an effective antitumor immune response?</li></ul><b><p><b>IN-PERSON BREAKOUT TABLE 9: Tumor Microenvironment (TME) Models for Mechanistic Studies</b></p></b><p><i>Moderator: Jason Yu, PhD, Senior Postdoctoral Associate, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology</i></p><b></b><ul type="disc"><li>What aspects of the TME require <i>ex vivo </i>modeling?</li><li>What are the challenges in modeling tumor immune responses?</li><li>What are the unique advantages of <i>ex vivo </i>TME models?</li><li>How do we advance <i>ex vivo</i> TME models for drug discovery and mechanistic studies?</li></ul><b></b></div> </div></div> </div> <div class="col-sm-3"> <div id="Contentplaceholder1_T39935FB7001_Col01" class="sf_colsIn pad-lr" data-sf-element="Column 2" data-placeholder-label="Column 2"><div class='sfContentBlock'> <br class="hidden-md hidden-lg" /><div class="social-icons"><a target="_blank" title="Outlook" href="/docs/librariesprovider48/ics/24/imx24.ics?sfvrsn=95fcb176_1&download=true"><img src="/images/default-source/social/calendar-gray.png?sfvrsn=91696e36_6" title="Outlook" alt="Outlook" class="social-icon" /></a> <a title="YouTube" href="http://www.youtube.com/CambridgeHealthtech/" target="_blank"><img src="/images/default-source/social/youtube-gray.png?sfvrsn=6bad7b8f_4" title="YouTube" alt="YouTube" 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