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lang="it" dir="ltr"><style data-mw-deduplicate="TemplateStyles:r139142988">.mw-parser-output .hatnote-content{align-items:center;display:flex}.mw-parser-output .hatnote-icon{flex-shrink:0}.mw-parser-output .hatnote-icon img{display:flex}.mw-parser-output .hatnote-text{font-style:italic}body:not(.skin-minerva) .mw-parser-output .hatnote{border:1px solid #CCC;display:flex;margin:.5em 0;padding:.2em .5em}body:not(.skin-minerva) .mw-parser-output .hatnote-text{padding-left:.5em}body.skin-minerva .mw-parser-output .hatnote-icon{padding-right:8px}body.skin-minerva .mw-parser-output .hatnote-icon img{height:auto;width:16px}body.skin--responsive .mw-parser-output .hatnote a.new{color:#d73333}body.skin--responsive .mw-parser-output .hatnote a.new:visited{color:#a55858}</style> <div class="hatnote noprint disclaimer"> <div class="hatnote-content"><span class="noviewer hatnote-icon" typeof="mw:File"><span><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f7/Nuvola_apps_important.svg/18px-Nuvola_apps_important.svg.png" decoding="async" width="18" height="15" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f7/Nuvola_apps_important.svg/27px-Nuvola_apps_important.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f7/Nuvola_apps_important.svg/36px-Nuvola_apps_important.svg.png 2x" data-file-width="600" data-file-height="500" /></span></span> <span class="hatnote-text">Le informazioni riportate non sono consigli medici e potrebbero non essere accurate. I contenuti hanno solo fine illustrativo e non sostituiscono il parere medico: <a href="/wiki/Wikipedia:Disclaimer_medico" title="Wikipedia:Disclaimer medico">leggi le avvertenze</a>.</span></div> </div> <figure class="mw-halign-right" typeof="mw:File/Frame"><a href="/wiki/File:Pharmacokinetics_(Cp_over_time)_curve-it.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Pharmacokinetics_%28Cp_over_time%29_curve-it.svg/450px-Pharmacokinetics_%28Cp_over_time%29_curve-it.svg.png" decoding="async" width="450" height="402" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Pharmacokinetics_%28Cp_over_time%29_curve-it.svg/675px-Pharmacokinetics_%28Cp_over_time%29_curve-it.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Pharmacokinetics_%28Cp_over_time%29_curve-it.svg/900px-Pharmacokinetics_%28Cp_over_time%29_curve-it.svg.png 2x" data-file-width="450" data-file-height="402" /></a><figcaption>Descrizione grafica della finestra terapeutica in un grafico concentrazione/tempo.<sup id="cite_ref-fonte_1-0" class="reference"><a href="#cite_note-fonte-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></figcaption></figure> <p>La <b>finestra terapeutica</b>, anche chiamata <b>intervallo terapeutico</b>, è un parametro <a href="/wiki/Farmacologia" title="Farmacologia">farmacologico</a> che è indice della sicurezza di un <a href="/wiki/Farmaco" title="Farmaco">farmaco</a>. È definito come l'intervallo fra la concentrazione minima al di sotto della quale il farmaco è clinicamente inefficace e la concentrazione massima al di sopra della quale compaiono effetti tossici </p><p>Tanto più è ampia la finestra terapeutica, tanto più il farmaco è sicuro (maneggevole). </p> <div class="mw-heading mw-heading2"><h2 id="Note">Note</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Finestra_terapeutica&veaction=edit&section=1" title="Modifica la sezione Note" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Finestra_terapeutica&action=edit&section=1" title="Edit section's source code: Note"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-fonte-1"><a href="#cite_ref-fonte_1-0"><b>^</b></a> <span class="reference-text"><cite class="citation cita" style="font-style:normal"><a href="#CITEREFGandG">GandG</a></cite>.</span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Bibliografia">Bibliografia</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Finestra_terapeutica&veaction=edit&section=2" title="Modifica la sezione Bibliografia" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Finestra_terapeutica&action=edit&section=2" title="Edit section's source code: Bibliografia"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>(<span style="font-weight:bolder; font-size:80%"><abbr title="inglese">EN</abbr></span>) <cite id="CITEREFGandG" class="citation libro" style="font-style:normal"> Laurence Brunton, <i>et al.</i>, <a rel="nofollow" class="external text" href="http://www.accessmedicine.com"><span style="font-style:italic;">Goodman and Gilman's Manual of Pharmacology and Therapeutics</span></a>, 12ª ed., McGraw-Hill Professional, 28 settembre 2007, p. 642, <a href="/wiki/Digital_object_identifier" title="Digital object identifier">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.1036%2F0071443436">10.1036/0071443436</a>, <a href="/wiki/Speciale:RicercaISBN/9780071443432" class="internal mw-magiclink-isbn">ISBN 978-00-714-4343-2</a>.</cite></li></ul> <style data-mw-deduplicate="TemplateStyles:r141815314">.mw-parser-output .navbox{border:1px solid #aaa;clear:both;margin:auto;padding:2px;width:100%}.mw-parser-output .navbox th{padding-left:1em;padding-right:1em;text-align:center}.mw-parser-output .navbox>tbody>tr:first-child>th{background:#ccf;font-size:90%;width:100%;color:var(--color-base,black)}.mw-parser-output .navbox_navbar{float:left;margin:0;padding:0 10px 0 0;text-align:left;width:6em}.mw-parser-output .navbox_title{font-size:110%}.mw-parser-output .navbox_abovebelow{background:#ddf;font-size:90%;font-weight:normal}.mw-parser-output .navbox_group{background:#ddf;font-size:90%;padding:0 10px;white-space:nowrap}.mw-parser-output .navbox_list{font-size:90%;width:100%}.mw-parser-output .navbox_list a{white-space:nowrap}html:not(.vector-feature-night-mode-enabled) .mw-parser-output .navbox_odd{background:#fdfdfd;color:var(--color-base,black)}html:not(.vector-feature-night-mode-enabled) .mw-parser-output .navbox_even{background:#f7f7f7;color:var(--color-base,black)}.mw-parser-output .navbox a.mw-selflink{color:var(--color-base,black)}.mw-parser-output .navbox_center{text-align:center}.mw-parser-output .navbox .navbox_image{padding-left:7px;vertical-align:middle;width:0}.mw-parser-output .navbox+.navbox{margin-top:-1px}.mw-parser-output .navbox .mw-collapsible-toggle{font-weight:normal;text-align:right;width:7em}body.skin--responsive .mw-parser-output .navbox_image img{max-width:none!important}.mw-parser-output .subnavbox{margin:-3px;width:100%}.mw-parser-output .subnavbox_group{background:#e6e6ff;padding:0 10px}@media screen{html.skin-theme-clientpref-night .mw-parser-output .navbox>tbody>tr:first-child>th{background:var(--background-color-interactive)!important}html.skin-theme-clientpref-night .mw-parser-output .navbox th{color:var(--color-base)!important}html.skin-theme-clientpref-night .mw-parser-output .navbox_abovebelow,html.skin-theme-clientpref-night .mw-parser-output .navbox_group{background:var(--background-color-interactive-subtle)!important}html.skin-theme-clientpref-night .mw-parser-output .subnavbox_group{background:var(--background-color-neutral-subtle)!important}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbox>tbody>tr:first-child>th{background:var(--background-color-interactive)!important}html.skin-theme-clientpref-os .mw-parser-output .navbox th{color:var(--color-base)!important}html.skin-theme-clientpref-os .mw-parser-output .navbox_abovebelow,html.skin-theme-clientpref-os .mw-parser-output .navbox_group{background:var(--background-color-interactive-subtle)!important}html.skin-theme-clientpref-os .mw-parser-output .subnavbox_group{background:var(--background-color-neutral-subtle)!important}}</style><table class="navbox mw-collapsible mw-collapsed noprint metadata" id="navbox-Farmacologia"><tbody><tr><th colspan="2" style="background:#efefef"><div class="navbox_navbar"><div class="noprint plainlinks" style="background-color:transparent; padding:0; font-size:xx-small; color:var(--color-base, #000000); white-space:nowrap;"><a href="/wiki/Template:Farmacologia" title="Template:Farmacologia"><span title="Vai alla pagina del template">V</span></a> · <a href="/w/index.php?title=Discussioni_template:Farmacologia&action=edit&redlink=1" class="new" title="Discussioni template:Farmacologia (la pagina non esiste)"><span title="Discuti del template">D</span></a> · <a class="external text" href="https://it.wikipedia.org/w/index.php?title=Template:Farmacologia&action=edit"><span title="Modifica il template. Usa l'anteprima prima di salvare">M</span></a></div></div><span class="navbox_title"><a href="/wiki/Farmacologia" title="Farmacologia">Farmacologia</a></span></th></tr><tr><th colspan="1" class="navbox_group"><a href="/wiki/Farmacocinetica" title="Farmacocinetica">Farmacocinetica</a></th><td colspan="1" class="navbox_list navbox_odd"><a href="/wiki/ADME" title="ADME">ADME</a>:<b> ·</b> <a href="/w/index.php?title=Assorbimento_(farmacologia)&action=edit&redlink=1" class="new" title="Assorbimento (farmacologia) (la pagina non esiste)">Assorbimento</a><b> ·</b> <a href="/w/index.php?title=Distribuzione_(farmacologia)&action=edit&redlink=1" class="new" title="Distribuzione (farmacologia) (la pagina non esiste)">Distribuzione</a><b> ·</b> <a href="/wiki/Biotrasformazione" title="Biotrasformazione">Biotrasformazione</a><b> ·</b> <a href="/wiki/Escrezione" title="Escrezione">Escrezione</a> (<a href="/wiki/Clearance" title="Clearance">Clearance</a>)<b> ·</b> <a href="/w/index.php?title=Parametri_Farmacocinetici&action=edit&redlink=1" class="new" title="Parametri Farmacocinetici (la pagina non esiste)">Parametri Farmacocinetici</a><b> ·</b> <a href="/w/index.php?title=Dose_di_carico&action=edit&redlink=1" class="new" title="Dose di carico (la pagina non esiste)">Dose di carico</a><b> ·</b> <a href="/wiki/Volume_di_distribuzione" title="Volume di distribuzione">Volume di distribuzione</a><b> ·</b> <a href="/wiki/Bioequivalenza" title="Bioequivalenza">Bioequivalenza</a><b> ·</b> <a href="/wiki/Biodisponibilit%C3%A0" title="Biodisponibilità">Biodisponibilità</a><b> ·</b> <a href="/wiki/Emivita_(farmacologia)" title="Emivita (farmacologia)">Emivita</a><b> ·</b> <a href="/wiki/Legame_dei_farmaci_alle_proteine_plasmatiche" title="Legame dei farmaci alle proteine plasmatiche">Legame dei farmaci alle proteine plasmatiche</a><b> ·</b> <a href="/wiki/Indice_terapeutico" title="Indice terapeutico">Indice terapeutico</a> (<a href="/wiki/DL50" title="DL50">DL50</a> / <a href="/wiki/ED50" title="ED50">ED50</a>)<b> ·</b> <a class="mw-selflink selflink">Finestra terapeutica</a></td></tr><tr><th colspan="1" class="navbox_group"><a href="/wiki/Farmacodinamica" title="Farmacodinamica">Farmacodinamica</a></th><td colspan="1" class="navbox_list navbox_even"><a href="/w/index.php?title=Curva_dose-risposta&action=edit&redlink=1" class="new" title="Curva dose-risposta (la pagina non esiste)">Curva dose-risposta</a><b> ·</b> (<a href="/w/index.php?title=Efficacia_(farmacologia)&action=edit&redlink=1" class="new" title="Efficacia (farmacologia) (la pagina non esiste)">Efficacia</a><b> ·</b> <a href="/wiki/Potenza_(farmacologia)" title="Potenza (farmacologia)">Potenza</a>) <a href="/w/index.php?title=Farmacodinamica_antimicrobica&action=edit&redlink=1" class="new" title="Farmacodinamica antimicrobica (la pagina non esiste)">Farmacodinamica antimicrobica</a>:<b> ·</b> <a href="/wiki/Concentrazione_minima_inibitoria" title="Concentrazione minima inibitoria">Concentrazione minima inibitoria</a>/<a href="/wiki/Batteriostatico" title="Batteriostatico">Batteriostatico</a><b> ·</b> <a href="/wiki/Concentrazione_minima_battericida" title="Concentrazione minima battericida">Concentrazione minima battericida</a>/<a href="/wiki/Battericida" title="Battericida">Battericida</a></td></tr><tr><th colspan="1" class="navbox_group">Agonismo ed Antagonismo</th><td colspan="1" class="navbox_list navbox_odd"><a href="/wiki/Agonista" title="Agonista">Agonista</a>:<b> ·</b> <a href="/w/index.php?title=Agonista_inverso&action=edit&redlink=1" class="new" title="Agonista inverso (la pagina non esiste)">Agonista inverso</a><b> ·</b> <a href="/w/index.php?title=Agonista_irreversibile&action=edit&redlink=1" class="new" title="Agonista irreversibile (la pagina non esiste)">Agonista irreversibile</a><b> ·</b> <a href="/w/index.php?title=Agonista_parziale&action=edit&redlink=1" class="new" title="Agonista parziale (la pagina non esiste)">Agonista parziale</a><b> ·</b> <a href="/wiki/Superagonista" title="Superagonista">Superagonista</a> <p><a href="/wiki/Antagonista_(biochimica)" title="Antagonista (biochimica)">Antagonista</a>:<b> ·</b> <a href="/w/index.php?title=Antagonista_competitivo&action=edit&redlink=1" class="new" title="Antagonista competitivo (la pagina non esiste)">Antagonista competitivo</a><b> ·</b> <a href="/w/index.php?title=Antagonista_irreversibile&action=edit&redlink=1" class="new" title="Antagonista irreversibile (la pagina non esiste)">Antagonista irreversibile</a> </p> Altro:<b> ·</b> <a href="/wiki/Legame_(molecolare)" class="mw-redirect" title="Legame (molecolare)">Legame (molecolare)</a></td></tr><tr><th colspan="1" class="navbox_group">Altro</th><td colspan="1" class="navbox_list navbox_even"><b> ·</b> <a href="/w/index.php?title=Tolleranza_farmacologica&action=edit&redlink=1" class="new" title="Tolleranza farmacologica (la pagina non esiste)">Tolleranza farmacologica</a>:<b> ·</b> <a href="/wiki/Tachifilassi" title="Tachifilassi">Tachifilassi</a><b> ·</b> <a href="/wiki/Farmacoresistenza" title="Farmacoresistenza">Farmacoresistenza</a>:<b> ·</b> <a href="/wiki/Resistenza_agli_antibiotici" title="Resistenza agli antibiotici">Resistenza agli antibiotici</a><b> ·</b> <a href="/wiki/Resistenza_multifarmaco" title="Resistenza multifarmaco">Resistenza multifarmaco</a></td></tr><tr><th colspan="1" class="navbox_group">Campi connessi</th><td colspan="1" class="navbox_list navbox_odd"><a href="/wiki/Farmacogenetica" title="Farmacogenetica">Farmacogenetica</a><b> ·</b> <a href="/wiki/Farmacogenomica" title="Farmacogenomica">Farmacogenomica</a><b> ·</b> <a href="/wiki/Neuropsicofarmacologia" title="Neuropsicofarmacologia">Neuropsicofarmacologia</a><b> ·</b> (<a href="/w/index.php?title=Neurofarmacologia&action=edit&redlink=1" class="new" title="Neurofarmacologia (la pagina non esiste)">Neurofarmacologia</a>, <a href="/wiki/Psicofarmacologia" 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