Center for Neuroscience and Regeneration Research < Center for Neuroscience and Regeneration Research

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class="generic-paragraph__text"><p>The goal of our research is to harness the “molecular revolution” to restore function in the injured nervous system. Our objective is to promote functional recovery following spinal cord injury, multiple sclerosis, stroke, traumatic brain injury and neuropathic pain.</p> <p>We are a multidisciplinary team of scientists and clinicians researching ways to reverse the paralyzing effects of nerve demyelination, identify mechanisms that mediate pain after injury to the nervous system, and apply pharmacological and cell-based approaches to restore neurological function.</p> <p>Our vision of the future is one in which, as a result of advances in molecular, cellular and regenerative research, the effects of nervous system damage will be substantially mitigated, or completely reversed.</p></div></div></div> </section></div><div class="component-wrapper component-wrapper--all"><article class="article-widget" aria-label="Latest News"><div class="article-widget__title-container"><div class="heading__container"><h2 class="article-widget__title" id="latest-news">Latest News</h2><div 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Waxman, MD, PhD, Earns Prestigious Julius Axelrod Prize" class="article-post article-post--small"><div class="article-post__date-container"><span class="article-post-date">November 03, 2018</span></div><a href="/cnrr/news-article/stephen-g-waxman-md-phd-earns-prestigious-julius-axelrod-prize/" class="article-post-content-link" aria-label="Stephen G. Waxman, MD, PhD, Earns Prestigious Julius Axelrod Prize" tabindex="-1"><div class="article-post__thumbnail"><div class="article-post-thumbnail" style="aspect-ratio:3 / 2"><span class="" style="display:inline-block"></span></div></div><div class="article-post__title-wrapper"><h3 class="article-post-title article-post-title--size-mode--small">Stephen G. Waxman, MD, PhD, Earns Prestigious Julius Axelrod Prize</h3></div></a><div class="article-post__link-details-wrapper"><div class="article-post-link-details"><a href="/cnrr/news-article/stephen-g-waxman-md-phd-earns-prestigious-julius-axelrod-prize/" tabindex="0" class="link link--size--small link--width--inline link--align--right link--color--black link--font--normal link--decorate-color--light-blue" aria-label="Read more about Stephen G. Waxman, MD, PhD, Earns Prestigious Julius Axelrod Prize"><span class="link__label">Read more<span class="visually-hidden-content" role="presentation">about Stephen G. Waxman, MD, PhD, Earns Prestigious Julius Axelrod Prize</span></span></a></div></div></article></li><li class="article-list__post article-list__post--small"><article aria-label="How a Single Gene Could Become a Volume Knob for Pain" class="article-post article-post--small"><div class="article-post__date-container"><span class="article-post-date">April 18, 2017</span></div><a href="https://www.wired.com/2017/04/the-cure-for-pain/" class="article-post-content-link" aria-label="How a Single Gene Could Become a Volume Knob for Pain, Source: Wired" tabindex="-1"><div class="article-post__thumbnail"><div class="article-post-thumbnail" style="aspect-ratio:3 / 2"><span class="" style="display:inline-block"></span></div></div><div class="article-post__title-wrapper"><h3 class="article-post-title article-post-title--size-mode--small">How a Single Gene Could Become a Volume Knob for Pain</h3></div><span class="article-source-label article-post__source-label">Source: Wired</span></a><div 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In this episode of “Intention to Treat,” Rachel Gotbaum talks with a patient with neuropathic pain and a researcher exploring new sodium-channel blockers that offer promise for such patients.","thumbnail":null,"url":"https://www.nejm.org/doi/full/10.1056/NEJMp2305759","isFeatured":false,"source":"The New England Journal of Medicine"},{"id":"53439","bylineDate":"2023-08-03T04:00:00+00:00","title":"Science Behind the Study: Targeting a Peripheral Sodium Channel to Treat Pain","summary":"This editorial describes the science behind clinical trials of an inhibitor of the sodium channel Nav1.8 to treat acute postoperative pain.","thumbnail":null,"url":"https://www.nejm.org/doi/full/10.1056/NEJMe2305708","isFeatured":false,"source":"The New England Journal of Medicine"},{"id":"43131","bylineDate":"2022-02-17T04:00:00+00:00","title":"NIH Awards HEAL Grant to Study Novel Ways to Treat Pain","summary":"A team of researchers—including Yale School of Medicine’s Sulayman D. Dib-Hajj, PhD, senior research scientist in neurology, Stephen G. Waxman, MD, PhD, professor of neurology, and Lakshmi Bangalore, PhD, lecturer in neurology—has been awarded funding through the NIH HEAL Initiative: Team Research for Initial Translational Efforts in Non-addictive Analgesic Therapeutics Development.","thumbnail":{"imageId":0,"url":"https://ysm-res.cloudinary.com/image/upload/v1/yms/prod/d40b3ed4-5959-46e4-ab9d-990ae5578787","altText":"heal-initiative","width":1000,"height":605,"imageVariants":[{"dimension":"Square","url":"https://ysm-res.cloudinary.com/image/upload/c_crop,x_198,y_0,w_605,h_605/v1/yms/prod/d40b3ed4-5959-46e4-ab9d-990ae5578787","width":605,"height":605,"aspectRatio":"ratio1x1"},{"dimension":"Rectangle","url":"https://ysm-res.cloudinary.com/image/upload/c_crop,x_0,y_34,w_1000,h_536/v1/yms/prod/d40b3ed4-5959-46e4-ab9d-990ae5578787","width":1000,"height":536,"aspectRatio":"ratio16x9"}]},"url":"/cnrr/news-article/nih-awards-heal-grant-to-study-novel-ways-to-treat-pain/","isFeatured":false,"source":null},{"id":"21649","bylineDate":"2019-10-23T04:00:00+00:00","title":"Scientists Discover How Nerve Cells Build Their Electrically Excitable Membranes","summary":"Scientists at Yale School of Medicine and Veterans Affairs Connecticut Healthcare System show at single-molecule resolution how nerve cells build their electrically excitable membranes.","thumbnail":{"imageId":0,"url":"https://ysm-res.cloudinary.com/image/upload/v1/yms/prod/729f4468-490c-4a8f-9039-93eb259df9aa","altText":"Image for News Item 23Oct2019","width":850,"height":850,"imageVariants":[{"dimension":"Square","url":"https://ysm-res.cloudinary.com/image/upload/v1/yms/prod/5884d96b-f5c2-4b96-81d6-75a3084f18e9","width":850,"height":850,"aspectRatio":"ratio1x1"},{"dimension":"Rectangle","url":"https://ysm-res.cloudinary.com/image/upload/v1/yms/prod/5bb6b762-85dc-4433-b0ae-57fa28ef40b9","width":850,"height":583,"aspectRatio":"ratio3x2"}]},"url":"/cnrr/news-article/scientists-discover-how-nerve-cells-build-their-electrically-excitable-membranes/","isFeatured":false,"source":null},{"id":"18921","bylineDate":"2018-12-05T04:00:00+00:00","title":"Scientists Identify Method to Study Resilience to Pain","summary":"Scientists at the Yale School of Medicine and Veterans Affairs Connecticut Healthcare System have successfully demonstrated that it is possible to pinpoint genes that contribute to inter-individual differences in pain.","thumbnail":{"imageId":0,"url":"https://ysm-res.cloudinary.com/image/upload/v1/yms/prod/98ca540c-58a3-42a1-9944-9d4fe116fa0d","altText":"Waxman","width":4500,"height":1500,"imageVariants":[{"dimension":"Square","url":"https://ysm-res.cloudinary.com/image/upload/v1/yms/prod/0be25727-d95e-4c89-b00b-af5e0e8ef3fb","width":826,"height":826,"aspectRatio":"ratio1x1"},{"dimension":"Rectangle","url":"https://ysm-res.cloudinary.com/image/upload/v1/yms/prod/16677a09-60a4-409d-a239-9f6f65b6c979","width":1201,"height":824,"aspectRatio":"ratio3x2"}]},"url":"/cnrr/news-article/scientists-identify-method-to-study-resilience-to-pain/","isFeatured":false,"source":null},{"id":"18675","bylineDate":"2018-11-03T04:00:00+00:00","title":"Stephen G. Waxman, MD, PhD, Earns Prestigious Julius Axelrod Prize","summary":"The Society for Neuroscience (SfN) has announced that Stephen G. Waxman, MD, PhD, Bridget M. Flaherty Professor of Neurology and professor of neurobiology and of pharmacology, is this year's recipient of its Julius Axelrod Prize.","thumbnail":{"imageId":0,"url":"https://ysm-res.cloudinary.com/image/upload/v1/yms/prod/0f67de18-1d0f-4fd2-95be-a136d9416aee","altText":"Waxman","width":4500,"height":1500,"imageVariants":[{"dimension":"Square","url":"https://ysm-res.cloudinary.com/image/upload/v1/yms/prod/9534cd10-6e5d-4176-8046-145bb9b81690","width":824,"height":824,"aspectRatio":"ratio1x1"},{"dimension":"Rectangle","url":"https://ysm-res.cloudinary.com/image/upload/v1/yms/prod/8f8ec365-cd33-458a-81a8-b5458995a71e","width":1204,"height":826,"aspectRatio":"ratio3x2"}]},"url":"/cnrr/news-article/stephen-g-waxman-md-phd-earns-prestigious-julius-axelrod-prize/","isFeatured":false,"source":null},{"id":"14863","bylineDate":"2017-04-18T04:00:00+00:00","title":"How a Single Gene Could Become a Volume Knob for Pain","summary":"On a scale of 1 to 10, how would you rate your pain? 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