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Perhaps you can return to the site’s home page and see if you can find what you are looking for.</p> </div> <div class="sections__item --link_icon"><a class="link" href="/" title="Return home" muted="muted"> Return home <div class="media media--svg --view-mode--default"> <div class="media-svg-1"> <div class="media-svg-1__item"> <svg xmlns="http://www.w3.org/2000/svg" width="26.945" height="23.535" viewBox="0 0 26.945 23.535"><g transform="translate(1.768 1.768)"><path d="M23.927.5H0" transform="translate(0 9.5)" fill="none" stroke="#fff" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.5"/><path d="M10.255,10,0,0" transform="translate(0 10)" fill="none" stroke="#fff" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.5"/><path d="M10.255,0,0,10" transform="translate(0)" fill="none" stroke="#fff" stroke-linecap="round" stroke-linejoin="round" stroke-miterlimit="10" stroke-width="2.5"/></g></svg> </div> </div> </div> </a> </div> </div> </div> </article> </div> <div id="isi" id="block-isi" class="isi-inline"> <div class="container"> <div class="body"> <div class="body__item"><h1>Important Safety Information and Indication</h1> <h2>Important Safety Information</h2> <h3>Reduced Serum Vitamin A Levels and Recommended Supplementation</h3> <p>AMVUTTRA® (vutrisiran) treatment leads to a decrease in serum vitamin A levels.</p> <p>Supplementation at the recommended daily allowance (RDA) of vitamin A is advised for patients taking AMVUTTRA. Higher doses than the RDA should not be given to try to achieve normal serum vitamin A levels during treatment with AMVUTTRA, as serum vitamin A levels do not reflect the total vitamin A in the body.</p> <p>Patients should be referred to an ophthalmologist if they develop ocular symptoms suggestive of vitamin A deficiency (e.g., night blindness).</p> <h3>Adverse Reactions</h3> <p>The most common adverse reactions that occurred in patients treated with AMVUTTRA were pain in extremity (15%), arthralgia (11%), dyspnea (7%), and vitamin A decreased (7%).</p> <h2>Indication</h2> <p>AMVUTTRA is indicated for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults.</p> <h3>For additional information about AMVUTTRA, please see the full <a href="https://www.alnylam.com/sites/default/files/pdfs/amvuttra-us-prescribing-information.pdf" target="_blank">Prescribing Information</a>.</h3> <ul> <li><a href="/sign-up">Sign up for updates</a></li> </ul> </div> </div> </div> </div> <div class="isi-tray collapsed"> <div class="container relative"> <button class="toggle-isi"> <img class="open" src="/themes/amvuttra/assets/images/0.0-icn-plus.svg" alt="Open ISI" /> <img class="close" src="/themes/amvuttra/assets/images/0.0-icn-x-lg.svg" alt="Close ISI" /> </button> <div class="paragraphs"> <div class="paragraphs__item --collection_of_blocks"> <div class="blocks"> <div class="blocks__item --embed_blocks"> <div class="block-list"> <div class="block-list__item"> <div class="body"> <div class="body__item"><h1>Important Safety Information and Indication</h1> <h2>Important Safety Information</h2> <h3>Reduced Serum Vitamin A Levels and Recommended Supplementation</h3> <p>AMVUTTRA® (vutrisiran) treatment leads to a decrease in serum vitamin A levels.</p> <p>Supplementation at the recommended daily allowance (RDA) of vitamin A is advised for patients taking AMVUTTRA. Higher doses than the RDA should not be given to try to achieve normal serum vitamin A levels during treatment with AMVUTTRA, as serum vitamin A levels do not reflect the total vitamin A in the body.</p> <p>Patients should be referred to an ophthalmologist if they develop ocular symptoms suggestive of vitamin A deficiency (e.g., night blindness).</p> <h3>Adverse Reactions</h3> <p>The most common adverse reactions that occurred in patients treated with AMVUTTRA were pain in extremity (15%), arthralgia (11%), dyspnea (7%), and vitamin A decreased (7%).</p> <h2>Indication</h2> <p>AMVUTTRA is indicated for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults.</p> <h3>For additional information about AMVUTTRA, please see the full <a href="https://www.alnylam.com/sites/default/files/pdfs/amvuttra-us-prescribing-information.pdf" target="_blank">Prescribing Information</a>.</h3> <ul> <li><a href="/sign-up">Sign up for updates</a></li> </ul> </div> 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