CINXE.COM

PLOS Pathogens

<!doctype html> <html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en" itemscope itemtype="http://schema.org/Article" class="no-js"> <head prefix="og: http://ogp.me/ns#"> <base href="https://journals.plos.org/plospathogens/s/reviewer-guidelines"> <link rel="stylesheet" href="/resource/css/site-content.css?112d78c04dc25a6fb55b68d577e0729a"><!-- allows for extra head tags --> <!-- hello --> <link rel="stylesheet" type="text/css" href="https://fonts.googleapis.com/css?family=Open+Sans:400,400i,600"> <link media="print" rel="stylesheet" type="text/css" href="/resource/css/print.css"> <script type="text/javascript"> var siteUrlPrefix = "/plospathogens/"; </script> <script src="/resource/js/vendor/modernizr-v2.7.1.js" type="text/javascript"></script> <script src="/resource/js/vendor/detectizr.min.js" type="text/javascript"></script> <link rel="shortcut icon" href="/resource/img/favicon.ico" type="image/x-icon"> <meta http-equiv="Content-Type" content="text/html; charset=utf-8"><!-- DoubleClick overall ad setup script --> <script type="text/javascript"> var googletag = googletag || {}; googletag.cmd = googletag.cmd || []; (function() { var gads = document.createElement('script'); gads.async = true; gads.type = 'text/javascript'; var useSSL = 'https:' == document.location.protocol; gads.src = (useSSL ? 'https:' : 'http:') + '//www.googletagservices.com/tag/js/gpt.js'; var node = document.getElementsByTagName('script')[0]; node.parentNode.insertBefore(gads, node); })(); </script><!-- DoubleClick ad slot setup script --> <script id="doubleClickSetupScript" type="text/javascript"> googletag.cmd.push(function() { googletag.defineSlot('/75507958/PPATH_728x90_ATF', [728, 90], 'div-gpt-ad-1458247671871-0').addService(googletag.pubads()); var personalizedAds = window.plosCookieConsent && window.plosCookieConsent.hasConsented('advertising'); googletag.pubads().setRequestNonPersonalizedAds(personalizedAds ? 0 : 1); googletag.pubads().enableSingleRequest(); googletag.enableServices(); }); </script> <script type="text/javascript"> var WombatConfig = WombatConfig || {}; WombatConfig.journalKey = "PLoSPathogens"; WombatConfig.journalName = "PLOS Pathogens"; WombatConfig.figurePath = "/plospathogens/article/figure/image"; WombatConfig.figShareInstitutionString = "plos"; WombatConfig.doiResolverPrefix = "https://dx.plos.org/"; </script> <script type="text/javascript"> var WombatConfig = WombatConfig || {}; WombatConfig.metrics = WombatConfig.metrics || {}; WombatConfig.metrics.referenceUrl = "http://lagotto.io/plos"; WombatConfig.metrics.googleScholarUrl = "https://scholar.google.com/scholar"; WombatConfig.metrics.googleScholarCitationUrl = WombatConfig.metrics.googleScholarUrl + "?hl=en&lr=&q="; WombatConfig.metrics.crossrefUrl = "https://www.crossref.org"; </script> <script defer src="/resource/js/defer.js?5d23b84e5e396356b27c"></script> <script src="/resource/js/sync.js?5d23b84e5e396356b27c"></script> <script src="/resource/js/vendor/jquery.min.js" type="text/javascript"></script> <script src="/resource/js/vendor/fastclick/lib/fastclick.js" type="text/javascript"></script> <script src="/resource/js/vendor/foundation/foundation.js" type="text/javascript"></script> <script src="/resource/js/vendor/underscore-min.js" type="text/javascript"></script> <script src="/resource/js/vendor/underscore.string.min.js" type="text/javascript"></script> <script src="/resource/js/vendor/moment.js" type="text/javascript"></script> <script src="/resource/js/vendor/jquery-ui-effects.min.js" type="text/javascript"></script> <script src="/resource/js/vendor/foundation/foundation.tooltip.js" type="text/javascript"></script> <script src="/resource/js/vendor/foundation/foundation.dropdown.js" type="text/javascript"></script> <script src="/resource/js/vendor/foundation/foundation.tab.js" type="text/javascript"></script> <script src="/resource/js/vendor/foundation/foundation.reveal.js" type="text/javascript"></script> <script src="/resource/js/vendor/foundation/foundation.slider.js" type="text/javascript"></script> <script src="/resource/js/util/utils.js" type="text/javascript"></script> <script src="/resource/js/components/toggle.js" type="text/javascript"></script> <script src="/resource/js/components/truncate_elem.js" type="text/javascript"></script> <script src="/resource/js/components/tooltip_hover.js" type="text/javascript"></script> <script src="/resource/js/vendor/jquery.dotdotdot.js" type="text/javascript"></script><!--For Google Tag manager to be able to track site information --> <script> dataLayer = [{ 'mobileSite': 'false', 'desktopSite': 'true' }]; </script> <title>PLOS Pathogens</title><!-- for lemur --> <script> $(document).ready(()=> { let lemurTitle = $('article > h1').text(); if (lemurTitle && lemurTitle != '') { $('title').text(lemurTitle + ' | ' + 'PLOS Pathogens'); } }); </script> <meta http-equiv="X-Translated-By" content="Google"> <meta http-equiv="X-Translated-To" content="ru"> <script type="text/javascript" src="https://www.gstatic.com/_/translate_http/_/js/k=translate_http.tr.en_GB.tKc6KWkFf-8.O/am=gAE/d=1/rs=AN8SPfrf36LIV3DkhtRBGWFnLWWzaykPyw/m=corsproxy" data-sourceurl="https://journals.plos.org/plospathogens/s/reviewer-guidelines"></script> <link href="https://fonts.googleapis.com/css2?family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20..48,100..700,0..1,-50..200" rel="stylesheet"> <script type="text/javascript" src="https://www.gstatic.com/_/translate_http/_/js/k=translate_http.tr.en_GB.tKc6KWkFf-8.O/am=gAE/d=1/exm=corsproxy/ed=1/rs=AN8SPfrf36LIV3DkhtRBGWFnLWWzaykPyw/m=phishing_protection" data-phishing-protection-enabled="false" data-forms-warning-enabled="true" data-source-url="https://journals.plos.org/plospathogens/s/reviewer-guidelines"></script> <meta name="robots" content="none"> </head> <body class="static plospathogens"> <script type="text/javascript" src="https://www.gstatic.com/_/translate_http/_/js/k=translate_http.tr.en_GB.tKc6KWkFf-8.O/am=gAE/d=1/exm=corsproxy,phishing_protection/ed=1/rs=AN8SPfrf36LIV3DkhtRBGWFnLWWzaykPyw/m=navigationui" data-environment="prod" data-proxy-url="https://journals-plos-org.translate.goog" data-proxy-full-url="https://journals-plos-org.translate.goog/plospathogens/s/reviewer-guidelines?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB" data-source-url="https://journals.plos.org/plospathogens/s/reviewer-guidelines" data-source-language="pl" data-target-language="ru" data-display-language="en-GB" data-detected-source-language="" data-is-source-untranslated="false" data-source-untranslated-url="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://journals.plos.org/plospathogens/s/reviewer-guidelines&amp;anno=2" data-client="tr"></script><!-- Google Tag Manager --> <noscript> <iframe src="//www.googletagmanager.com/ns.html?id=GTM-TP26BH" height="0" width="0" style="display:none;visibility:hidden"></iframe> </noscript> <script> (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= '//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-TP26BH'); </script> <noscript> <iframe src="//www.googletagmanager.com/ns.html?id=GTM-MQQMGF" height="0" width="0" style="display:none;visibility:hidden"></iframe> </noscript> <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= '//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-MQQMGF');</script><!-- End Google Tag Manager --> <!-- Start of HubSpot Embed Code --> <script> // from https://developers.hubspot.com/docs/reference/api/analytics-and-events/cookie-banner/cookie-banner-api#example-using-a-third-party-cookie-banner-to-control-hubspot-cookies window.disableHubSpotCookieBanner = true; window._hsp = window._hsp || []; window._hsp.push(['setHubSpotConsent', { analytics: window.plosCookieConsent?.hasConsented('analytics'), advertisement: window.plosCookieConsent?.hasConsented('advertising'), functionality: window.plosCookieConsent?.hasConsented('functionality') } ]); </script> <script type="text/javascript" id="hs-script-loader" async defer src="//js.hs-scripts.com/44092021.js"></script><!-- End of HubSpot Embed Code --> <!-- New Relic --> <script type="text/javascript"> ;window.NREUM||(NREUM={});NREUM.init={distributed_tracing:{enabled:true},privacy:{cookies_enabled:true},ajax:{deny_list:["bam.nr-data.net"]}}; window.NREUM||(NREUM={}),__nr_require=function(t,e,n){function r(n){if(!e[n]){var o=e[n]={exports:{}};t[n][0].call(o.exports,function(e){var o=t[n][1][e];return r(o||e)},o,o.exports)}return e[n].exports}if("function"==typeof __nr_require)return __nr_require;for(var o=0;o<n.length;o++)r(n[o]);return r}({1:[function(t,e,n){function r(t){try{s.console&&console.log(t)}catch(e){}}var o,i=t("ee"),a=t(32),s={};try{o=localStorage.getItem("__nr_flags").split(","),console&&"function"==typeof console.log&&(s.console=!0,o.indexOf("dev")!==-1&&(s.dev=!0),o.indexOf("nr_dev")!==-1&&(s.nrDev=!0))}catch(c){}s.nrDev&&i.on("internal-error",function(t){r(t.stack)}),s.dev&&i.on("fn-err",function(t,e,n){r(n.stack)}),s.dev&&(r("NR AGENT IN DEVELOPMENT MODE"),r("flags: "+a(s,function(t,e){return t}).join(", ")))},{}],2:[function(t,e,n){function r(t,e,n,r,s){try{l?l-=1:o(s||new UncaughtException(t,e,n),!0)}catch(f){try{i("ierr",[f,c.now(),!0])}catch(d){}}return"function"==typeof u&&u.apply(this,a(arguments))}function UncaughtException(t,e,n){this.message=t||"Uncaught error with no additional information",this.sourceURL=e,this.line=n}function o(t,e){var n=e?null:c.now();i("err",[t,n])}var i=t("handle"),a=t(33),s=t("ee"),c=t("loader"),f=t("gos"),u=window.onerror,d=!1,p="nr@seenError";if(!c.disabled){var l=0;c.features.err=!0,t(1),window.onerror=r;try{throw new Error}catch(h){"stack"in h&&(t(14),t(13),"addEventListener"in window&&t(7),c.xhrWrappable&&t(15),d=!0)}s.on("fn-start",function(t,e,n){d&&(l+=1)}),s.on("fn-err",function(t,e,n){d&&!n[p]&&(f(n,p,function(){return!0}),this.thrown=!0,o(n))}),s.on("fn-end",function(){d&&!this.thrown&&l>0&&(l-=1)}),s.on("internal-error",function(t){i("ierr",[t,c.now(),!0])})}},{}],3:[function(t,e,n){var r=t("loader");r.disabled||(r.features.ins=!0)},{}],4:[function(t,e,n){function r(){U++,L=g.hash,this[u]=y.now()}function o(){U--,g.hash!==L&&i(0,!0);var t=y.now();this[h]=~~this[h]+t-this[u],this[d]=t}function i(t,e){E.emit("newURL",[""+g,e])}function a(t,e){t.on(e,function(){this[e]=y.now()})}var s="-start",c="-end",f="-body",u="fn"+s,d="fn"+c,p="cb"+s,l="cb"+c,h="jsTime",m="fetch",v="addEventListener",w=window,g=w.location,y=t("loader");if(w[v]&&y.xhrWrappable&&!y.disabled){var x=t(11),b=t(12),E=t(9),R=t(7),O=t(14),T=t(8),P=t(15),S=t(10),M=t("ee"),N=M.get("tracer"),C=t(23);t(17),y.features.spa=!0;var L,U=0;M.on(u,r),b.on(p,r),S.on(p,r),M.on(d,o),b.on(l,o),S.on(l,o),M.buffer([u,d,"xhr-resolved"]),R.buffer([u]),O.buffer(["setTimeout"+c,"clearTimeout"+s,u]),P.buffer([u,"new-xhr","send-xhr"+s]),T.buffer([m+s,m+"-done",m+f+s,m+f+c]),E.buffer(["newURL"]),x.buffer([u]),b.buffer(["propagate",p,l,"executor-err","resolve"+s]),N.buffer([u,"no-"+u]),S.buffer(["new-jsonp","cb-start","jsonp-error","jsonp-end"]),a(T,m+s),a(T,m+"-done"),a(S,"new-jsonp"),a(S,"jsonp-end"),a(S,"cb-start"),E.on("pushState-end",i),E.on("replaceState-end",i),w[v]("hashchange",i,C(!0)),w[v]("load",i,C(!0)),w[v]("popstate",function(){i(0,U>1)},C(!0))}},{}],5:[function(t,e,n){function r(){var t=new PerformanceObserver(function(t,e){var n=t.getEntries();s(v,[n])});try{t.observe({entryTypes:["resource"]})}catch(e){}}function o(t){if(s(v,[window.performance.getEntriesByType(w)]),window.performance["c"+p])try{window.performance[h](m,o,!1)}catch(t){}else try{window.performance[h]("webkit"+m,o,!1)}catch(t){}}function i(t){}if(window.performance&&window.performance.timing&&window.performance.getEntriesByType){var a=t("ee"),s=t("handle"),c=t(14),f=t(13),u=t(6),d=t(23),p="learResourceTimings",l="addEventListener",h="removeEventListener",m="resourcetimingbufferfull",v="bstResource",w="resource",g="-start",y="-end",x="fn"+g,b="fn"+y,E="bstTimer",R="pushState",O=t("loader");if(!O.disabled){O.features.stn=!0,t(9),"addEventListener"in window&&t(7);var T=NREUM.o.EV;a.on(x,function(t,e){var n=t[0];n instanceof T&&(this.bstStart=O.now())}),a.on(b,function(t,e){var n=t[0];n instanceof T&&s("bst",[n,e,this.bstStart,O.now()])}),c.on(x,function(t,e,n){this.bstStart=O.now(),this.bstType=n}),c.on(b,function(t,e){s(E,[e,this.bstStart,O.now(),this.bstType])}),f.on(x,function(){this.bstStart=O.now()}),f.on(b,function(t,e){s(E,[e,this.bstStart,O.now(),"requestAnimationFrame"])}),a.on(R+g,function(t){this.time=O.now(),this.startPath=location.pathname+location.hash}),a.on(R+y,function(t){s("bstHist",[location.pathname+location.hash,this.startPath,this.time])}),u()?(s(v,[window.performance.getEntriesByType("resource")]),r()):l in window.performance&&(window.performance["c"+p]?window.performance[l](m,o,d(!1)):window.performance[l]("webkit"+m,o,d(!1))),document[l]("scroll",i,d(!1)),document[l]("keypress",i,d(!1)),document[l]("click",i,d(!1))}}},{}],6:[function(t,e,n){e.exports=function(){return"PerformanceObserver"in window&&"function"==typeof window.PerformanceObserver}},{}],7:[function(t,e,n){function r(t){for(var e=t;e&&!e.hasOwnProperty(u);)e=Object.getPrototypeOf(e);e&&o(e)}function o(t){s.inPlace(t,[u,d],"-",i)}function i(t,e){return t[1]}var a=t("ee").get("events"),s=t("wrap-function")(a,!0),c=t("gos"),f=XMLHttpRequest,u="addEventListener",d="removeEventListener";e.exports=a,"getPrototypeOf"in Object?(r(document),r(window),r(f.prototype)):f.prototype.hasOwnProperty(u)&&(o(window),o(f.prototype)),a.on(u+"-start",function(t,e){var n=t[1];if(null!==n&&("function"==typeof n||"object"==typeof n)){var r=c(n,"nr@wrapped",function(){function t(){if("function"==typeof n.handleEvent)return n.handleEvent.apply(n,arguments)}var e={object:t,"function":n}[typeof n];return e?s(e,"fn-",null,e.name||"anonymous"):n});this.wrapped=t[1]=r}}),a.on(d+"-start",function(t){t[1]=this.wrapped||t[1]})},{}],8:[function(t,e,n){function r(t,e,n){var r=t[e];"function"==typeof r&&(t[e]=function(){var t=i(arguments),e={};o.emit(n+"before-start",[t],e);var a;e[m]&&e[m].dt&&(a=e[m].dt);var s=r.apply(this,t);return o.emit(n+"start",[t,a],s),s.then(function(t){return o.emit(n+"end",[null,t],s),t},function(t){throw o.emit(n+"end",[t],s),t})})}var o=t("ee").get("fetch"),i=t(33),a=t(32);e.exports=o;var s=window,c="fetch-",f=c+"body-",u=["arrayBuffer","blob","json","text","formData"],d=s.Request,p=s.Response,l=s.fetch,h="prototype",m="nr@context";d&&p&&l&&(a(u,function(t,e){r(d[h],e,f),r(p[h],e,f)}),r(s,"fetch",c),o.on(c+"end",function(t,e){var n=this;if(e){var r=e.headers.get("content-length");null!==r&&(n.rxSize=r),o.emit(c+"done",[null,e],n)}else o.emit(c+"done",[t],n)}))},{}],9:[function(t,e,n){var r=t("ee").get("history"),o=t("wrap-function")(r);e.exports=r;var i=window.history&&window.history.constructor&&window.history.constructor.prototype,a=window.history;i&&i.pushState&&i.replaceState&&(a=i),o.inPlace(a,["pushState","replaceState"],"-")},{}],10:[function(t,e,n){function r(t){function e(){f.emit("jsonp-end",[],l),t.removeEventListener("load",e,c(!1)),t.removeEventListener("error",n,c(!1))}function n(){f.emit("jsonp-error",[],l),f.emit("jsonp-end",[],l),t.removeEventListener("load",e,c(!1)),t.removeEventListener("error",n,c(!1))}var r=t&&"string"==typeof t.nodeName&&"script"===t.nodeName.toLowerCase();if(r){var o="function"==typeof t.addEventListener;if(o){var a=i(t.src);if(a){var d=s(a),p="function"==typeof d.parent[d.key];if(p){var l={};u.inPlace(d.parent,[d.key],"cb-",l),t.addEventListener("load",e,c(!1)),t.addEventListener("error",n,c(!1)),f.emit("new-jsonp",[t.src],l)}}}}}function o(){return"addEventListener"in window}function i(t){var e=t.match(d);return e?e[1]:null}function a(t,e){var n=t.match(l),r=n[1],o=n[3];return o?a(o,e[r]):e[r]}function s(t){var e=t.match(p);return e&&e.length>=3?{key:e[2],parent:a(e[1],window)}:{key:t,parent:window}}var c=t(23),f=t("ee").get("jsonp"),u=t("wrap-function")(f);if(e.exports=f,o()){var d=/[?&](?:callback|cb)=([^&#]+)/,p=/(.*)\.([^.]+)/,l=/^(\w+)(\.|$)(.*)$/,h=["appendChild","insertBefore","replaceChild"];Node&&Node.prototype&&Node.prototype.appendChild?u.inPlace(Node.prototype,h,"dom-"):(u.inPlace(HTMLElement.prototype,h,"dom-"),u.inPlace(HTMLHeadElement.prototype,h,"dom-"),u.inPlace(HTMLBodyElement.prototype,h,"dom-")),f.on("dom-start",function(t){r(t[0])})}},{}],11:[function(t,e,n){var r=t("ee").get("mutation"),o=t("wrap-function")(r),i=NREUM.o.MO;e.exports=r,i&&(window.MutationObserver=function(t){return this instanceof i?new i(o(t,"fn-")):i.apply(this,arguments)},MutationObserver.prototype=i.prototype)},{}],12:[function(t,e,n){function r(t){var e=i.context(),n=s(t,"executor-",e,null,!1),r=new f(n);return i.context(r).getCtx=function(){return e},r}var o=t("wrap-function"),i=t("ee").get("promise"),a=t("ee").getOrSetContext,s=o(i),c=t(32),f=NREUM.o.PR;e.exports=i,f&&(window.Promise=r,["all","race"].forEach(function(t){var e=f[t];f[t]=function(n){function r(t){return function(){i.emit("propagate",[null,!o],a,!1,!1),o=o||!t}}var o=!1;c(n,function(e,n){Promise.resolve(n).then(r("all"===t),r(!1))});var a=e.apply(f,arguments),s=f.resolve(a);return s}}),["resolve","reject"].forEach(function(t){var e=f[t];f[t]=function(t){var n=e.apply(f,arguments);return t!==n&&i.emit("propagate",[t,!0],n,!1,!1),n}}),f.prototype["catch"]=function(t){return this.then(null,t)},f.prototype=Object.create(f.prototype,{constructor:{value:r}}),c(Object.getOwnPropertyNames(f),function(t,e){try{r[e]=f[e]}catch(n){}}),o.wrapInPlace(f.prototype,"then",function(t){return function(){var e=this,n=o.argsToArray.apply(this,arguments),r=a(e);r.promise=e,n[0]=s(n[0],"cb-",r,null,!1),n[1]=s(n[1],"cb-",r,null,!1);var c=t.apply(this,n);return r.nextPromise=c,i.emit("propagate",[e,!0],c,!1,!1),c}}),i.on("executor-start",function(t){t[0]=s(t[0],"resolve-",this,null,!1),t[1]=s(t[1],"resolve-",this,null,!1)}),i.on("executor-err",function(t,e,n){t[1](n)}),i.on("cb-end",function(t,e,n){i.emit("propagate",[n,!0],this.nextPromise,!1,!1)}),i.on("propagate",function(t,e,n){this.getCtx&&!e||(this.getCtx=function(){if(t instanceof Promise)var e=i.context(t);return e&&e.getCtx?e.getCtx():this})}),r.toString=function(){return""+f})},{}],13:[function(t,e,n){var r=t("ee").get("raf"),o=t("wrap-function")(r),i="equestAnimationFrame";e.exports=r,o.inPlace(window,["r"+i,"mozR"+i,"webkitR"+i,"msR"+i],"raf-"),r.on("raf-start",function(t){t[0]=o(t[0],"fn-")})},{}],14:[function(t,e,n){function r(t,e,n){t[0]=a(t[0],"fn-",null,n)}function o(t,e,n){this.method=n,this.timerDuration=isNaN(t[1])?0:+t[1],t[0]=a(t[0],"fn-",this,n)}var i=t("ee").get("timer"),a=t("wrap-function")(i),s="setTimeout",c="setInterval",f="clearTimeout",u="-start",d="-";e.exports=i,a.inPlace(window,[s,"setImmediate"],s+d),a.inPlace(window,[c],c+d),a.inPlace(window,[f,"clearImmediate"],f+d),i.on(c+u,r),i.on(s+u,o)},{}],15:[function(t,e,n){function r(t,e){d.inPlace(e,["onreadystatechange"],"fn-",s)}function o(){var t=this,e=u.context(t);t.readyState>3&&!e.resolved&&(e.resolved=!0,u.emit("xhr-resolved",[],t)),d.inPlace(t,y,"fn-",s)}function i(t){x.push(t),m&&(E?E.then(a):w?w(a):(R=-R,O.data=R))}function a(){for(var t=0;t<x.length;t++)r([],x[t]);x.length&&(x=[])}function s(t,e){return e}function c(t,e){for(var n in t)e[n]=t[n];return e}t(7);var f=t("ee"),u=f.get("xhr"),d=t("wrap-function")(u),p=t(23),l=NREUM.o,h=l.XHR,m=l.MO,v=l.PR,w=l.SI,g="readystatechange",y=["onload","onerror","onabort","onloadstart","onloadend","onprogress","ontimeout"],x=[];e.exports=u;var b=window.XMLHttpRequest=function(t){var e=new h(t);try{u.emit("new-xhr",[e],e),e.addEventListener(g,o,p(!1))}catch(n){try{u.emit("internal-error",[n])}catch(r){}}return e};if(c(h,b),b.prototype=h.prototype,d.inPlace(b.prototype,["open","send"],"-xhr-",s),u.on("send-xhr-start",function(t,e){r(t,e),i(e)}),u.on("open-xhr-start",r),m){var E=v&&v.resolve();if(!w&&!v){var R=1,O=document.createTextNode(R);new m(a).observe(O,{characterData:!0})}}else f.on("fn-end",function(t){t[0]&&t[0].type===g||a()})},{}],16:[function(t,e,n){function r(t){if(!s(t))return null;var e=window.NREUM;if(!e.loader_config)return null;var n=(e.loader_config.accountID||"").toString()||null,r=(e.loader_config.agentID||"").toString()||null,f=(e.loader_config.trustKey||"").toString()||null;if(!n||!r)return null;var h=l.generateSpanId(),m=l.generateTraceId(),v=Date.now(),w={spanId:h,traceId:m,timestamp:v};return(t.sameOrigin||c(t)&&p())&&(w.traceContextParentHeader=o(h,m),w.traceContextStateHeader=i(h,v,n,r,f)),(t.sameOrigin&&!u()||!t.sameOrigin&&c(t)&&d())&&(w.newrelicHeader=a(h,m,v,n,r,f)),w}function o(t,e){return"00-"+e+"-"+t+"-01"}function i(t,e,n,r,o){var i=0,a="",s=1,c="",f="";return o+"@nr="+i+"-"+s+"-"+n+"-"+r+"-"+t+"-"+a+"-"+c+"-"+f+"-"+e}function a(t,e,n,r,o,i){var a="btoa"in window&&"function"==typeof window.btoa;if(!a)return null;var s={v:[0,1],d:{ty:"Browser",ac:r,ap:o,id:t,tr:e,ti:n}};return i&&r!==i&&(s.d.tk=i),btoa(JSON.stringify(s))}function s(t){return f()&&c(t)}function c(t){var e=!1,n={};if("init"in NREUM&&"distributed_tracing"in NREUM.init&&(n=NREUM.init.distributed_tracing),t.sameOrigin)e=!0;else if(n.allowed_origins instanceof Array)for(var r=0;r<n.allowed_origins.length;r++){var o=h(n.allowed_origins[r]);if(t.hostname===o.hostname&&t.protocol===o.protocol&&t.port===o.port){e=!0;break}}return e}function f(){return"init"in NREUM&&"distributed_tracing"in NREUM.init&&!!NREUM.init.distributed_tracing.enabled}function u(){return"init"in NREUM&&"distributed_tracing"in NREUM.init&&!!NREUM.init.distributed_tracing.exclude_newrelic_header}function d(){return"init"in NREUM&&"distributed_tracing"in NREUM.init&&NREUM.init.distributed_tracing.cors_use_newrelic_header!==!1}function p(){return"init"in NREUM&&"distributed_tracing"in NREUM.init&&!!NREUM.init.distributed_tracing.cors_use_tracecontext_headers}var l=t(29),h=t(18);e.exports={generateTracePayload:r,shouldGenerateTrace:s}},{}],17:[function(t,e,n){function r(t){var e=this.params,n=this.metrics;if(!this.ended){this.ended=!0;for(var r=0;r<p;r++)t.removeEventListener(d[r],this.listener,!1);e.aborted||(n.duration=a.now()-this.startTime,this.loadCaptureCalled||4!==t.readyState?null==e.status&&(e.status=0):i(this,t),n.cbTime=this.cbTime,s("xhr",[e,n,this.startTime,this.endTime,"xhr"],this))}}function o(t,e){var n=c(e),r=t.params;r.hostname=n.hostname,r.port=n.port,r.protocol=n.protocol,r.host=n.hostname+":"+n.port,r.pathname=n.pathname,t.parsedOrigin=n,t.sameOrigin=n.sameOrigin}function i(t,e){t.params.status=e.status;var n=v(e,t.lastSize);if(n&&(t.metrics.rxSize=n),t.sameOrigin){var r=e.getResponseHeader("X-NewRelic-App-Data");r&&(t.params.cat=r.split(", ").pop())}t.loadCaptureCalled=!0}var a=t("loader");if(a.xhrWrappable&&!a.disabled){var s=t("handle"),c=t(18),f=t(16).generateTracePayload,u=t("ee"),d=["load","error","abort","timeout"],p=d.length,l=t("id"),h=t(24),m=t(22),v=t(19),w=t(23),g=NREUM.o.REQ,y=window.XMLHttpRequest;a.features.xhr=!0,t(15),t(8),u.on("new-xhr",function(t){var e=this;e.totalCbs=0,e.called=0,e.cbTime=0,e.end=r,e.ended=!1,e.xhrGuids={},e.lastSize=null,e.loadCaptureCalled=!1,e.params=this.params||{},e.metrics=this.metrics||{},t.addEventListener("load",function(n){i(e,t)},w(!1)),h&&(h>34||h<10)||t.addEventListener("progress",function(t){e.lastSize=t.loaded},w(!1))}),u.on("open-xhr-start",function(t){this.params={method:t[0]},o(this,t[1]),this.metrics={}}),u.on("open-xhr-end",function(t,e){"loader_config"in NREUM&&"xpid"in NREUM.loader_config&&this.sameOrigin&&e.setRequestHeader("X-NewRelic-ID",NREUM.loader_config.xpid);var n=f(this.parsedOrigin);if(n){var r=!1;n.newrelicHeader&&(e.setRequestHeader("newrelic",n.newrelicHeader),r=!0),n.traceContextParentHeader&&(e.setRequestHeader("traceparent",n.traceContextParentHeader),n.traceContextStateHeader&&e.setRequestHeader("tracestate",n.traceContextStateHeader),r=!0),r&&(this.dt=n)}}),u.on("send-xhr-start",function(t,e){var n=this.metrics,r=t[0],o=this;if(n&&r){var i=m(r);i&&(n.txSize=i)}this.startTime=a.now(),this.listener=function(t){try{"abort"!==t.type||o.loadCaptureCalled||(o.params.aborted=!0),("load"!==t.type||o.called===o.totalCbs&&(o.onloadCalled||"function"!=typeof e.onload))&&o.end(e)}catch(n){try{u.emit("internal-error",[n])}catch(r){}}};for(var s=0;s<p;s++)e.addEventListener(d[s],this.listener,w(!1))}),u.on("xhr-cb-time",function(t,e,n){this.cbTime+=t,e?this.onloadCalled=!0:this.called+=1,this.called!==this.totalCbs||!this.onloadCalled&&"function"==typeof n.onload||this.end(n)}),u.on("xhr-load-added",function(t,e){var n=""+l(t)+!!e;this.xhrGuids&&!this.xhrGuids[n]&&(this.xhrGuids[n]=!0,this.totalCbs+=1)}),u.on("xhr-load-removed",function(t,e){var n=""+l(t)+!!e;this.xhrGuids&&this.xhrGuids[n]&&(delete this.xhrGuids[n],this.totalCbs-=1)}),u.on("xhr-resolved",function(){this.endTime=a.now()}),u.on("addEventListener-end",function(t,e){e instanceof y&&"load"===t[0]&&u.emit("xhr-load-added",[t[1],t[2]],e)}),u.on("removeEventListener-end",function(t,e){e instanceof y&&"load"===t[0]&&u.emit("xhr-load-removed",[t[1],t[2]],e)}),u.on("fn-start",function(t,e,n){e instanceof y&&("onload"===n&&(this.onload=!0),("load"===(t[0]&&t[0].type)||this.onload)&&(this.xhrCbStart=a.now()))}),u.on("fn-end",function(t,e){this.xhrCbStart&&u.emit("xhr-cb-time",[a.now()-this.xhrCbStart,this.onload,e],e)}),u.on("fetch-before-start",function(t){function e(t,e){var n=!1;return e.newrelicHeader&&(t.set("newrelic",e.newrelicHeader),n=!0),e.traceContextParentHeader&&(t.set("traceparent",e.traceContextParentHeader),e.traceContextStateHeader&&t.set("tracestate",e.traceContextStateHeader),n=!0),n}var n,r=t[1]||{};"string"==typeof t[0]?n=t[0]:t[0]&&t[0].url?n=t[0].url:window.URL&&t[0]&&t[0]instanceof URL&&(n=t[0].href),n&&(this.parsedOrigin=c(n),this.sameOrigin=this.parsedOrigin.sameOrigin);var o=f(this.parsedOrigin);if(o&&(o.newrelicHeader||o.traceContextParentHeader))if("string"==typeof t[0]||window.URL&&t[0]&&t[0]instanceof URL){var i={};for(var a in r)i[a]=r[a];i.headers=new Headers(r.headers||{}),e(i.headers,o)&&(this.dt=o),t.length>1?t[1]=i:t.push(i)}else t[0]&&t[0].headers&&e(t[0].headers,o)&&(this.dt=o)}),u.on("fetch-start",function(t,e){this.params={},this.metrics={},this.startTime=a.now(),this.dt=e,t.length>=1&&(this.target=t[0]),t.length>=2&&(this.opts=t[1]);var n,r=this.opts||{},i=this.target;"string"==typeof i?n=i:"object"==typeof i&&i instanceof g?n=i.url:window.URL&&"object"==typeof i&&i instanceof URL&&(n=i.href),o(this,n);var s=(""+(i&&i instanceof g&&i.method||r.method||"GET")).toUpperCase();this.params.method=s,this.txSize=m(r.body)||0}),u.on("fetch-done",function(t,e){this.endTime=a.now(),this.params||(this.params={}),this.params.status=e?e.status:0;var n;"string"==typeof this.rxSize&&this.rxSize.length>0&&(n=+this.rxSize);var r={txSize:this.txSize,rxSize:n,duration:a.now()-this.startTime};s("xhr",[this.params,r,this.startTime,this.endTime,"fetch"],this)})}},{}],18:[function(t,e,n){var r={};e.exports=function(t){if(t in r)return r[t];var e=document.createElement("a"),n=window.location,o={};e.href=t,o.port=e.port;var i=e.href.split("://");!o.port&&i[1]&&(o.port=i[1].split("/")[0].split("@").pop().split(":")[1]),o.port&&"0"!==o.port||(o.port="https"===i[0]?"443":"80"),o.hostname=e.hostname||n.hostname,o.pathname=e.pathname,o.protocol=i[0],"/"!==o.pathname.charAt(0)&&(o.pathname="/"+o.pathname);var a=!e.protocol||":"===e.protocol||e.protocol===n.protocol,s=e.hostname===document.domain&&e.port===n.port;return o.sameOrigin=a&&(!e.hostname||s),"/"===o.pathname&&(r[t]=o),o}},{}],19:[function(t,e,n){function r(t,e){var n=t.responseType;return"json"===n&&null!==e?e:"arraybuffer"===n||"blob"===n||"json"===n?o(t.response):"text"===n||""===n||void 0===n?o(t.responseText):void 0}var o=t(22);e.exports=r},{}],20:[function(t,e,n){function r(){}function o(t,e,n,r){return function(){return u.recordSupportability("API/"+e+"/called"),i(t+e,[f.now()].concat(s(arguments)),n?null:this,r),n?void 0:this}}var i=t("handle"),a=t(32),s=t(33),c=t("ee").get("tracer"),f=t("loader"),u=t(25),d=NREUM;"undefined"==typeof window.newrelic&&(newrelic=d);var p=["setPageViewName","setCustomAttribute","setErrorHandler","finished","addToTrace","inlineHit","addRelease"],l="api-",h=l+"ixn-";a(p,function(t,e){d[e]=o(l,e,!0,"api")}),d.addPageAction=o(l,"addPageAction",!0),d.setCurrentRouteName=o(l,"routeName",!0),e.exports=newrelic,d.interaction=function(){return(new r).get()};var m=r.prototype={createTracer:function(t,e){var n={},r=this,o="function"==typeof e;return i(h+"tracer",[f.now(),t,n],r),function(){if(c.emit((o?"":"no-")+"fn-start",[f.now(),r,o],n),o)try{return e.apply(this,arguments)}catch(t){throw c.emit("fn-err",[arguments,this,t],n),t}finally{c.emit("fn-end",[f.now()],n)}}}};a("actionText,setName,setAttribute,save,ignore,onEnd,getContext,end,get".split(","),function(t,e){m[e]=o(h,e)}),newrelic.noticeError=function(t,e){"string"==typeof t&&(t=new Error(t)),u.recordSupportability("API/noticeError/called"),i("err",[t,f.now(),!1,e])}},{}],21:[function(t,e,n){function r(t){if(NREUM.init){for(var e=NREUM.init,n=t.split("."),r=0;r<n.length-1;r++)if(e=e[n[r]],"object"!=typeof e)return;return e=e[n[n.length-1]]}}e.exports={getConfiguration:r}},{}],22:[function(t,e,n){e.exports=function(t){if("string"==typeof t&&t.length)return t.length;if("object"==typeof t){if("undefined"!=typeof ArrayBuffer&&t instanceof ArrayBuffer&&t.byteLength)return t.byteLength;if("undefined"!=typeof Blob&&t instanceof Blob&&t.size)return t.size;if(!("undefined"!=typeof FormData&&t instanceof FormData))try{return JSON.stringify(t).length}catch(e){return}}}},{}],23:[function(t,e,n){var r=!1;try{var o=Object.defineProperty({},"passive",{get:function(){r=!0}});window.addEventListener("testPassive",null,o),window.removeEventListener("testPassive",null,o)}catch(i){}e.exports=function(t){return r?{passive:!0,capture:!!t}:!!t}},{}],24:[function(t,e,n){var r=0,o=navigator.userAgent.match(/Firefox[\/\s](\d+\.\d+)/);o&&(r=+o[1]),e.exports=r},{}],25:[function(t,e,n){function r(t,e){var n=[a,t,{name:t},e];return i("storeMetric",n,null,"api"),n}function o(t,e){var n=[s,t,{name:t},e];return i("storeEventMetrics",n,null,"api"),n}var i=t("handle"),a="sm",s="cm";e.exports={constants:{SUPPORTABILITY_METRIC:a,CUSTOM_METRIC:s},recordSupportability:r,recordCustom:o}},{}],26:[function(t,e,n){function r(){return s.exists&&performance.now?Math.round(performance.now()):(i=Math.max((new Date).getTime(),i))-a}function o(){return i}var i=(new Date).getTime(),a=i,s=t(34);e.exports=r,e.exports.offset=a,e.exports.getLastTimestamp=o},{}],27:[function(t,e,n){function r(t){return!(!t||!t.protocol||"file:"===t.protocol)}e.exports=r},{}],28:[function(t,e,n){function r(t,e){var n=t.getEntries();n.forEach(function(t){"first-paint"===t.name?p("timing",["fp",Math.floor(t.startTime)]):"first-contentful-paint"===t.name&&p("timing",["fcp",Math.floor(t.startTime)])})}function o(t,e){var n=t.getEntries();if(n.length>0){var r=n[n.length-1];if(c&&c<r.startTime)return;p("lcp",[r])}}function i(t){t.getEntries().forEach(function(t){t.hadRecentInput||p("cls",[t])})}function a(t){if(t instanceof v&&!g){var e=Math.round(t.timeStamp),n={type:t.type};e<=l.now()?n.fid=l.now()-e:e>l.offset&&e<=Date.now()?(e-=l.offset,n.fid=l.now()-e):e=l.now(),g=!0,p("timing",["fi",e,n])}}function s(t){"hidden"===t&&(c=l.now(),p("pageHide",[c]))}if(!("init"in NREUM&&"page_view_timing"in NREUM.init&&"enabled"in NREUM.init.page_view_timing&&NREUM.init.page_view_timing.enabled===!1)){var c,f,u,d,p=t("handle"),l=t("loader"),h=t(31),m=t(23),v=NREUM.o.EV;if("PerformanceObserver"in window&&"function"==typeof window.PerformanceObserver){f=new PerformanceObserver(r);try{f.observe({entryTypes:["paint"]})}catch(w){}u=new PerformanceObserver(o);try{u.observe({entryTypes:["largest-contentful-paint"]})}catch(w){}d=new PerformanceObserver(i);try{d.observe({type:"layout-shift",buffered:!0})}catch(w){}}if("addEventListener"in document){var g=!1,y=["click","keydown","mousedown","pointerdown","touchstart"];y.forEach(function(t){document.addEventListener(t,a,m(!1))})}h(s)}},{}],29:[function(t,e,n){function r(){function t(){return e?15&e[n++]:16*Math.random()|0}var e=null,n=0,r=window.crypto||window.msCrypto;r&&r.getRandomValues&&(e=r.getRandomValues(new Uint8Array(31)));for(var o,i="xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx",a="",s=0;s<i.length;s++)o=i[s],"x"===o?a+=t().toString(16):"y"===o?(o=3&t()|8,a+=o.toString(16)):a+=o;return a}function o(){return a(16)}function i(){return a(32)}function a(t){function e(){return n?15&n[r++]:16*Math.random()|0}var n=null,r=0,o=window.crypto||window.msCrypto;o&&o.getRandomValues&&Uint8Array&&(n=o.getRandomValues(new Uint8Array(31)));for(var i=[],a=0;a<t;a++)i.push(e().toString(16));return i.join("")}e.exports={generateUuid:r,generateSpanId:o,generateTraceId:i}},{}],30:[function(t,e,n){function r(t,e){if(!o)return!1;if(t!==o)return!1;if(!e)return!0;if(!i)return!1;for(var n=i.split("."),r=e.split("."),a=0;a<r.length;a++)if(r[a]!==n[a])return!1;return!0}var o=null,i=null,a=/Version\/(\S+)\s+Safari/;if(navigator.userAgent){var s=navigator.userAgent,c=s.match(a);c&&s.indexOf("Chrome")===-1&&s.indexOf("Chromium")===-1&&(o="Safari",i=c[1])}e.exports={agent:o,version:i,match:r}},{}],31:[function(t,e,n){function r(t){function e(){t(s&&document[s]?document[s]:document[i]?"hidden":"visible")}"addEventListener"in document&&a&&document.addEventListener(a,e,o(!1))}var o=t(23);e.exports=r;var i,a,s;"undefined"!=typeof document.hidden?(i="hidden",a="visibilitychange",s="visibilityState"):"undefined"!=typeof document.msHidden?(i="msHidden",a="msvisibilitychange"):"undefined"!=typeof document.webkitHidden&&(i="webkitHidden",a="webkitvisibilitychange",s="webkitVisibilityState")},{}],32:[function(t,e,n){function r(t,e){var n=[],r="",i=0;for(r in t)o.call(t,r)&&(n[i]=e(r,t[r]),i+=1);return n}var o=Object.prototype.hasOwnProperty;e.exports=r},{}],33:[function(t,e,n){function r(t,e,n){e||(e=0),"undefined"==typeof n&&(n=t?t.length:0);for(var r=-1,o=n-e||0,i=Array(o<0?0:o);++r<o;)i[r]=t[e+r];return i}e.exports=r},{}],34:[function(t,e,n){e.exports={exists:"undefined"!=typeof window.performance&&window.performance.timing&&"undefined"!=typeof window.performance.timing.navigationStart}},{}],ee:[function(t,e,n){function r(){}function o(t){function e(t){return t&&t instanceof r?t:t?f(t,c,a):a()}function n(n,r,o,i,a){if(a!==!1&&(a=!0),!l.aborted||i){t&&a&&t(n,r,o);for(var s=e(o),c=m(n),f=c.length,u=0;u<f;u++)c[u].apply(s,r);var p=d[y[n]];return p&&p.push([x,n,r,s]),s}}function i(t,e){g[t]=m(t).concat(e)}function h(t,e){var n=g[t];if(n)for(var r=0;r<n.length;r++)n[r]===e&&n.splice(r,1)}function m(t){return g[t]||[]}function v(t){return p[t]=p[t]||o(n)}function w(t,e){l.aborted||u(t,function(t,n){e=e||"feature",y[n]=e,e in d||(d[e]=[])})}var g={},y={},x={on:i,addEventListener:i,removeEventListener:h,emit:n,get:v,listeners:m,context:e,buffer:w,abort:s,aborted:!1};return x}function i(t){return f(t,c,a)}function a(){return new r}function s(){(d.api||d.feature)&&(l.aborted=!0,d=l.backlog={})}var c="nr@context",f=t("gos"),u=t(32),d={},p={},l=e.exports=o();e.exports.getOrSetContext=i,l.backlog=d},{}],gos:[function(t,e,n){function r(t,e,n){if(o.call(t,e))return t[e];var r=n();if(Object.defineProperty&&Object.keys)try{return Object.defineProperty(t,e,{value:r,writable:!0,enumerable:!1}),r}catch(i){}return t[e]=r,r}var o=Object.prototype.hasOwnProperty;e.exports=r},{}],handle:[function(t,e,n){function r(t,e,n,r){o.buffer([t],r),o.emit(t,e,n)}var o=t("ee").get("handle");e.exports=r,r.ee=o},{}],id:[function(t,e,n){function r(t){var e=typeof t;return!t||"object"!==e&&"function"!==e?-1:t===window?0:a(t,i,function(){return o++})}var o=1,i="nr@id",a=t("gos");e.exports=r},{}],loader:[function(t,e,n){function r(){if(!P++){var t=T.info=NREUM.info,e=v.getElementsByTagName("script")[0];if(setTimeout(f.abort,3e4),!(t&&t.licenseKey&&t.applicationID&&e))return f.abort();c(R,function(e,n){t[e]||(t[e]=n)});var n=a();s("mark",["onload",n+T.offset],null,"api"),s("timing",["load",n]);var r=v.createElement("script");0===t.agent.indexOf("http://")||0===t.agent.indexOf("https://")?r.src=t.agent:r.src=h+"://"+t.agent,e.parentNode.insertBefore(r,e)}}function o(){"complete"===v.readyState&&i()}function i(){s("mark",["domContent",a()+T.offset],null,"api")}var a=t(26),s=t("handle"),c=t(32),f=t("ee"),u=t(30),d=t(27),p=t(21),l=t(23),h=p.getConfiguration("ssl")===!1?"http":"https",m=window,v=m.document,w="addEventListener",g="attachEvent",y=m.XMLHttpRequest,x=y&&y.prototype,b=!d(m.location);NREUM.o={ST:setTimeout,SI:m.setImmediate,CT:clearTimeout,XHR:y,REQ:m.Request,EV:m.Event,PR:m.Promise,MO:m.MutationObserver};var E=""+location,R={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net",agent:"js-agent.newrelic.com/nr-spa-1212.min.js"},O=y&&x&&x[w]&&!/CriOS/.test(navigator.userAgent),T=e.exports={offset:a.getLastTimestamp(),now:a,origin:E,features:{},xhrWrappable:O,userAgent:u,disabled:b};if(!b){t(20),t(28),v[w]?(v[w]("DOMContentLoaded",i,l(!1)),m[w]("load",r,l(!1))):(v[g]("onreadystatechange",o),m[g]("onload",r)),s("mark",["firstbyte",a.getLastTimestamp()],null,"api");var P=0}},{}],"wrap-function":[function(t,e,n){function r(t,e){function n(e,n,r,c,f){function nrWrapper(){var i,a,u,p;try{a=this,i=d(arguments),u="function"==typeof r?r(i,a):r||{}}catch(l){o([l,"",[i,a,c],u],t)}s(n+"start",[i,a,c],u,f);try{return p=e.apply(a,i)}catch(h){throw s(n+"err",[i,a,h],u,f),h}finally{s(n+"end",[i,a,p],u,f)}}return a(e)?e:(n||(n=""),nrWrapper[p]=e,i(e,nrWrapper,t),nrWrapper)}function r(t,e,r,o,i){r||(r="");var s,c,f,u="-"===r.charAt(0);for(f=0;f<e.length;f++)c=e[f],s=t[c],a(s)||(t[c]=n(s,u?c+r:r,o,c,i))}function s(n,r,i,a){if(!h||e){var s=h;h=!0;try{t.emit(n,r,i,e,a)}catch(c){o([c,n,r,i],t)}h=s}}return t||(t=u),n.inPlace=r,n.flag=p,n}function o(t,e){e||(e=u);try{e.emit("internal-error",t)}catch(n){}}function i(t,e,n){if(Object.defineProperty&&Object.keys)try{var r=Object.keys(t);return r.forEach(function(n){Object.defineProperty(e,n,{get:function(){return t[n]},set:function(e){return t[n]=e,e}})}),e}catch(i){o([i],n)}for(var a in t)l.call(t,a)&&(e[a]=t[a]);return e}function a(t){return!(t&&t instanceof Function&&t.apply&&!t[p])}function s(t,e){var n=e(t);return n[p]=t,i(t,n,u),n}function c(t,e,n){var r=t[e];t[e]=s(r,n)}function f(){for(var t=arguments.length,e=new Array(t),n=0;n<t;++n)e[n]=arguments[n];return e}var u=t("ee"),d=t(33),p="nr@original",l=Object.prototype.hasOwnProperty,h=!1;e.exports=r,e.exports.wrapFunction=s,e.exports.wrapInPlace=c,e.exports.argsToArray=f},{}]},{},["loader",2,17,5,3,4]); ;NREUM.loader_config={accountID:"804283",trustKey:"804283",agentID:"402703674",licenseKey:"cf99e8d2a3",applicationID:"402703674"} ;NREUM.info={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net",licenseKey:"cf99e8d2a3", // Modified this value from the generated script, to pass prod vs dev applicationID: window.location.hostname.includes('journals.plos.org') ? "402703674" : "402694889", sa:1} </script><!-- End New Relic --> <header> <div id="topslot" class="head-top"><a id="skip-to-content" tabindex="0" class="button" href="https://journals-plos-org.translate.goog/plospathogens/s/reviewer-guidelines?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#main-content"> Skip to main content </a> <div class="center"> <div class="title"> Advertisement </div><!-- DoubleClick Ad Zone --> <div class="advertisement" id="div-gpt-ad-1458247671871-0" style="width:728px; height:90px;"> <script type="text/javascript"> googletag.cmd.push(function() { googletag.display('div-gpt-ad-1458247671871-0'); }); </script> </div> </div> </div> <div id="user" class="nav" data-user-management-url="https://community.plos.org"> </div> <div id="pagehdr"> <nav class="nav-main"> <h1 class="logo"><a href="https://journals-plos-org.translate.goog/plospathogens/?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">PLOS Pathogens</a></h1> <section class="top-bar-section"> <ul class="nav-elements"> <li class="menu-section-header has-dropdown " id="browse"><span class="menu-section-header-title"> Browse </span> <ul class="menu-section dropdown " id="browse-dropdown-list"> <li><a href="https://journals-plos-org.translate.goog/plospathogens/issue?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Current Issue</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/volume?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Journal Archive</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/collections?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Collections</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/search?filterJournals=PLoSPathogens&amp;q=article_type:pearls&amp;sortOrder=DATE_NEWEST_FIRST&amp;_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Pearls</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/search?filterJournals=PLoSPathogens&amp;q=article_type:review&amp;sortOrder=DATE_NEWEST_FIRST&amp;_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Reviews</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/search?filterJournals=PLoSPathogens&amp;q=article_type:opinion&amp;sortOrder=DATE_NEWEST_FIRST&amp;_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Opinions</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/search?filterJournals=PLoSPathogens&amp;q=article_type:editorial&amp;sortOrder=DATE_NEWEST_FIRST&amp;_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Editorials</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/find-and-read-articles?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Find and Read Articles</a></li> </ul></li> <li class="multi-col-parent menu-section-header has-dropdown" id="publish">Publish <div class="dropdown mega "> <ul class="multi-col" id="publish-dropdown-list"> <li class="menu-section-header " id="submissions"><span class="menu-section-header-title"> Submissions </span> <ul class="menu-section " id="submissions-dropdown-list"> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/getting-started?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Getting Started</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/submission-guidelines?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Submission Guidelines</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/figures?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Figures</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/tables?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Tables</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/data-sharing-support?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Data Sharing Support</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/supporting-information?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Supporting Information</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/latex?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">LaTeX</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/other-article-types?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Other Article Types</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/preprints?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Preprints</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/revising-your-manuscript?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Revising Your Manuscript</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/submit-now?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Submit Now</a></li> </ul></li> <li class="menu-section-header " id="policies"><span class="menu-section-header-title"> Policies </span> <ul class="menu-section " id="policies-dropdown-list"> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/best-practices-in-research-reporting?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Best Practices in Research Reporting</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/human-subjects-research?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Human Subjects Research</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/animal-research?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Animal Research</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/competing-interests?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Competing Interests</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/disclosure-of-funding-sources?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Disclosure of Funding Sources</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/licenses-and-copyright?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Licenses and Copyright</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/data-availability?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Data Availability</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/complementary-research?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Complementary Research</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/materials-software-and-code-sharing?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Materials, Software and Code Sharing</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/ethical-publishing-practice?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Ethical Publishing Practice</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/authorship?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Authorship</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/corrections-expressions-of-concern-and-retractions?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Corrections, Expressions of Concern, and Retractions</a></li> </ul></li> <li class="menu-section-header " id="manuscript-review-and-publication"><span class="menu-section-header-title"> Manuscript Review and Publication </span> <ul class="menu-section " id="manuscript-review-and-publication-dropdown-list"> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/editorial-and-peer-review-process?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Editorial and Peer Review Process</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/reviewer-guidelines?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Guidelines for Reviewers</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/guidelines-for-editors?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Guidelines for Editors</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/accepted-manuscripts?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Accepted Manuscripts</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/comments?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Comments</a></li> </ul></li> </ul> <div class="calloutcontainer"> <h3 class="callout-headline">Submit Your Manuscript</h3> <div class="action-contain"> <p class="callout-content"><em>PLOS Pathogens</em> publishes Open Access research and commentary that significantly advance the understanding of pathogens and how they interact with host organisms.</p> <p class="button-contain"><a class="button button-default" href="https://journals-plos-org.translate.goog/plospathogens/s/submit-now?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB"> Get Started </a></p> </div><!-- opens in siteMenuCalloutDescription --> </div> </div></li> <li class="menu-section-header has-dropdown " id="about"><span class="menu-section-header-title"> About </span> <ul class="menu-section dropdown " id="about-dropdown-list"> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/journal-information?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Journal Information</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/editors-in-chief?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Editors-in-Chief</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/editorial-board?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Editorial Board</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/publishing-information?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Publishing Information</a></li> <li><a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://plos.org/publication-fees">Publication Fees</a></li> <li><a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://plos.org/press-and-media">Press and Media</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/s/contact?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">Contact</a></li> </ul></li> <script src="/resource/js/vendor/jquery.hoverIntent.js" type="text/javascript"></script> <script src="/resource/js/components/menu_drop.js" type="text/javascript"></script> <script src="/resource/js/components/hover_delay.js" type="text/javascript"></script> <li id="navsearch" class="head-search"> <form name="searchForm" action="/plospathogens/search" method="get"> <fieldset><legend>Search</legend> <label for="search">Search</label> <div class="search-contain"><input id="search" type="text" name="q" placeholder="SEARCH" required> <button id="headerSearchButton" type="submit" aria-label="Submit search"> <i title="Submit search" class="search-icon"></i> </button> </div> </fieldset><input type="hidden" name="filterJournals" value="PLoSPathogens"> </form><a id="advSearch" href="https://journals-plos-org.translate.goog/plospathogens/search?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB"> advanced search </a> <script src="/resource/js/components/placeholder_style.js" type="text/javascript"></script></li> </ul> </section> </nav> </div> </header> <main id="main-content"> <div class="lemur-content two-column"> <nav class="site-content-nav"> <ul class="nav-page"> <li data-anchor="loc-invitation-to-review" name="loc-invitation-to-review"><a href="https://journals-plos-org.translate.goog/plospathogens/s/reviewer-guidelines?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#loc-invitation-to-review"> Invitation to Review </a></li> <li data-anchor="loc-our-peer-review-process" name="loc-our-peer-review-process"><a href="https://journals-plos-org.translate.goog/plospathogens/s/reviewer-guidelines?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#loc-our-peer-review-process"> Our Peer Review Process </a> <ul> <li data-anchor="loc-best-practices-for-reviewers" name="loc-best-practices-for-reviewers"><a href="https://journals-plos-org.translate.goog/plospathogens/s/reviewer-guidelines?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#loc-best-practices-for-reviewers"> Best practices for reviewers </a></li> </ul></li> <li data-anchor="loc-what-to-assess" name="loc-what-to-assess"><a href="https://journals-plos-org.translate.goog/plospathogens/s/reviewer-guidelines?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#loc-what-to-assess"> What to Assess </a> <ul> <li data-anchor="loc-criteria-for-publication" name="loc-criteria-for-publication"><a href="https://journals-plos-org.translate.goog/plospathogens/s/reviewer-guidelines?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#loc-criteria-for-publication"> Criteria for publication </a></li> </ul></li> <li data-anchor="loc-writing-the-review" name="loc-writing-the-review"><a href="https://journals-plos-org.translate.goog/plospathogens/s/reviewer-guidelines?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#loc-writing-the-review"> Writing the review </a> <ul> <li data-anchor="loc-revisions" name="loc-revisions"><a href="https://journals-plos-org.translate.goog/plospathogens/s/reviewer-guidelines?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#loc-revisions"> Revisions </a></li> <li data-anchor="loc-editing-reviewers-reports" name="loc-editing-reviewers-reports"><a href="https://journals-plos-org.translate.goog/plospathogens/s/reviewer-guidelines?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#loc-editing-reviewers-reports"> Editing reviewers’ reports </a></li> </ul></li> <li data-anchor="loc-the-editorial-process" name="loc-the-editorial-process"><a href="https://journals-plos-org.translate.goog/plospathogens/s/reviewer-guidelines?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#loc-the-editorial-process"> The Editorial Process </a> <ul> <li data-anchor="loc-decision-process" name="loc-decision-process"><a href="https://journals-plos-org.translate.goog/plospathogens/s/reviewer-guidelines?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#loc-decision-process"> Decision process </a></li> <li data-anchor="loc-conflicting-reviews" name="loc-conflicting-reviews"><a href="https://journals-plos-org.translate.goog/plospathogens/s/reviewer-guidelines?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#loc-conflicting-reviews"> Conflicting reviews </a></li> </ul></li> <li data-anchor="loc-help" name="loc-help"><a href="https://journals-plos-org.translate.goog/plospathogens/s/reviewer-guidelines?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#loc-help"> Help </a></li> </ul> </nav> <article> <h1>Guidelines for Reviewers</h1> <div data-section-id="2333"> <p><em><i>PLOS Pathogens</i></em>&nbsp;relies on members of the scientific research community to assess the validity of articles under consideration through peer review.</p> </div> <div data-section-id="392"> <h2><a id="loc-invitation-to-review" name="loc-invitation-to-review" data-anchor-id="7852"></a>Invitation to Review</h2> </div> <div data-section-id="2334"> <p><em><i>PLOS Pathogens</i></em> editors select potential reviewers based on their expertise in research areas relevant to the manuscript under consideration. Reviewer invitations are sent by email from the journal's <a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://www.editorialmanager.com/ppathogens">Editorial Manager</a> submission system. Use the links in the invitation email to accept or decline, or check the “New Reviewer Invitations” folder on your Reviewer Main Menu screen in Editorial Manager. Accept an invitation only if you have the knowledge, time and objectivity necessary to provide an unbiased assessment of the research. In agreeing to complete a review, you also give permission to publish your review under a <a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution CC BY</a> license.</p> </div> <div data-section-id="2340"> <h2><a data-anchor-id="7853" id="loc-our-peer-review-process" name="loc-our-peer-review-process"></a>Our Peer Review Process</h2> <p><em><i>PLOS Pathogens</i></em> practices single-anonymized&nbsp;peer review by default, but offers opportunities for authors and reviewers to participate in signed and published peer review.</p> </div> <div data-section-id="2604"> <h3><a data-anchor-id="7854" id="loc-our-peer-review-model" name="loc-our-peer-review-model"></a>Our peer review model</h3> <table class="table-basic" style="width:746px"> <tbody> <tr> <td style="vertical-align: top;"> <div style="width: 70px;"><img alt="" class="img-default" src="/plospathogens/indirect/bc01908b54c53ef4046a399b7d39d477d11f513feb059d1b2324c1ef165088cc"> </div></td> <td><p style="margin-top: 0pt; margin-bottom: 0pt; line-height: 1.2;"><strong>Single-anonymized&nbsp;peer review</strong></p><p style="margin-top: 0pt; margin-bottom: 0pt; line-height: 1.2;">During the peer review process you will know the authors’ names, but your name will not be shared. Your review will appear in the editorial decision letter where it can be read by the authors and other reviewers.</p></td> </tr> <tr> <td style="vertical-align: top;"> <div style="width: 70px;"><img alt="" class="img-default" src="/plospathogens/indirect/4d6290e034aa74117b7d50ba4b1485aafc417f5c7df39fd9c5a0a0455c4917dc"> </div></td> <td><p style="margin-top: 0pt; margin-bottom: 0pt; line-height: 1.2;"><strong>Signed peer review</strong></p><p style="margin-top: 0pt; margin-bottom: 0pt; line-height: 1.2;">You can choose to sign your name to your review when you submit it. Remember, if you sign your name the authors and other reviewers of the manuscript will see it. If the authors choose to publish their peer review history your name will accompany your comments alongside the published article.</p></td> </tr> <tr> <td style="vertical-align: top;"> <div style="width: 70px;"><img alt="" class="img-default" src="/plospathogens/indirect/88119f7815792ff1dedfd8dd50fc88c9acc10f28f8878c04a3bcbb43e53ee124"> </div></td> <td><p style="margin-top: 0pt; margin-bottom: 0pt; line-height: 1.2;"><strong>Portable</strong></p><p style="margin-top: 0pt; margin-bottom: 0pt; line-height: 1.2;">If the authors subsequently choose to transfer their manuscript to another PLOS journal your review will accompany it. You may hear from editors at another PLOS journal for re-review. Reviewers for any PLOS journal should be willing to have their reviews considered by the editors of another PLOS journal.</p></td> </tr> <tr> <td style="vertical-align: top;"> <div style="width: 70px;"><img alt="" class="img-default" src="/plospathogens/indirect/d36f5873e5e213f7edd2087e71ec1a2782b1435fb831f6d1f71985e5690197e0"> </div></td> <td><p style="margin-top: 0pt; margin-bottom: 0pt; line-height: 1.2;"><strong>Published peer review history</strong></p><p style="margin-top: 0pt; margin-bottom: 0pt; line-height: 1.2;">If the authors decide to publish their&nbsp;<a data-parent-id="13" href="https://journals-plos-org.translate.goog/plospathogens/s/editorial-and-peer-review-process?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#loc-peer-review-history">peer review history​</a>,&nbsp;the editorial decision letter, including your review, will appear alongside the published article. Your name will not appear unless you choose to sign your review.</p></td> </tr> </tbody> </table> </div> <div data-section-id="2341"> <h3><a data-anchor-id="7856" id="loc-best-practices-for-reviewers" name="loc-best-practices-for-reviewers"></a>Best practices for reviewers</h3> <table class="table-basic"> <tbody> <tr> <td style="vertical-align: top"> <div style="width: 70px"><img alt="" class="img-default" src="/plospathogens/indirect/c09cccf98819190e7ff0b7da520989cd5fcf69415a4fa12b2cd8480c112f0f8c"> </div></td> <td><p style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;"><strong style="background-color:transparent; color:rgb(0, 0, 0); font-family:arial; font-size:11pt; font-variant-east-asian:normal; font-variant-numeric:normal; font-weight:700; vertical-align:baseline; white-space:pre-wrap">Declaring competing interests</strong></p><p style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;">A <a href="https://journals-plos-org.translate.goog/plospathogens/s/competing-interests?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">competing interest</a> is anything that interferes with or could be perceived as potentially interfering with, a thorough and objective assessment of a manuscript. Common examples of competing interests may include:</p><p style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p> <ul> <li style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;">A recent or current collaboration&nbsp;with any of the authors</li> <li style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;">Direct competition or a history of scientific conflict with any of the authors</li> <li style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;">An opportunity to profit financially from the work</li> </ul><p style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;">Do not accept a review assignment if you have a competing interest, or don’t feel able to give an objective assessment. If you’re unsure whether your relationship qualifies as a competing interest, contact the journal office for advice. If we ask you to complete the review anyway, be sure to declare the competing interest when you submit your review.</p></td> </tr> <tr> <td style="vertical-align: top"> <div style="width: 70px"><img alt="" class="img-default" src="/plospathogens/indirect/f6ece754f9f5c38c999e9168575282a5b9c08ae83614c4781cd660d2401b2d36"> </div></td> <td><p style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;"><strong style="background-color:transparent; color:rgb(0, 0, 0); font-family:arial; font-size:11pt; font-variant-east-asian:normal; font-variant-numeric:normal; font-weight:700; vertical-align:baseline; white-space:pre-wrap">Crediting collaborators</strong></p><p style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;">If you had help completing the review you must share your collaborator’s name with the journal when you submit the review, either by entering it in the ‘Confidential comments to the Editor’ field, or via <a href="mailto:plospathogens@plos.org?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">email</a>. Be careful not to include your collaborator’s name in the text of the review itself.</p></td> </tr> <tr> <td style="vertical-align: top"> <div style="width: 70px"><img alt="" class="img-default" src="/plospathogens/indirect/2ce6a953e475a8c025d81e2714139251c39ef56b5020a6936c2fc52c8fbbb237"> </div></td> <td><p style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;"><strong style="background-color:transparent; color:rgb(0, 0, 0); font-family:arial; font-size:11pt; font-variant-east-asian:normal; font-variant-numeric:normal; font-weight:700; vertical-align:baseline; white-space:pre-wrap">Confidentiality</strong></p><p style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;">Keep manuscripts and correspondence confidential and do not share information about submissions with any one else unless previously agreed with the editor. We expect that reviewers will not make use of any material or take advantage of any information they gain through the peer review process.</p><p style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;">&nbsp;</p><p style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;"><a data-parent-id="15" href="https://journals-plos-org.translate.goog/plospathogens/s/ethical-publishing-practice?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#loc-confidentiality">Read the PLOS Confidentiality Policy</a>.</p></td> </tr> <tr> <td style="vertical-align: top"> <div style="width: 70px"><img alt="" class="img-default" src="/plospathogens/indirect/41aa303ca68b221fc6103fa068ac31ca153dcadad5d93c31ed56e5417de7d8ec"> </div></td> <td><p style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;"><strong style="background-color:transparent; color:rgb(0, 0, 0); font-family:arial; font-size:11pt; font-variant-east-asian:normal; font-variant-numeric:normal; font-weight:700; vertical-align:baseline; white-space:pre-wrap">Reviewing a manuscript you’ve previously reviewed</strong></p><p style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;">If you reviewed the article at another journal, consider the manuscript as a new submission unless instructed otherwise. Keep in mind that it may have been revised since the last time you evaluated it, and <em><i>PLOS Pathogens</i>’s </em><a data-parent-id="45" href="https://journals-plos-org.translate.goog/plospathogens/s/reviewer-guidelines?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#loc-criteria-for-publication">criteria for publication</a> may differ from those of the other journal. When you submit your review, let the editor know that you reviewed a previous version of the manuscript at another journal.</p></td> </tr> <tr> <td style="vertical-align: top"> <div style="width: 70px"><img alt="" class="img-default" src="/plospathogens/indirect/d622ad8e024ce59232d9d6583bb364fef22177f899e699363f1158d1fba281c4"> </div></td> <td><p style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;"><strong style="background-color:transparent; color:rgb(0, 0, 0); font-family:arial; font-size:11pt; font-variant-east-asian:normal; font-variant-numeric:normal; font-weight:700; vertical-align:baseline; white-space:pre-wrap">Time to review</strong></p><p style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;">Aim to complete your review within 14&nbsp;days. If you need more time to perform the review, please <a href="mailto:plospathogens@plos.org?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">email us</a> as soon as possible.</p></td> </tr> </tbody> </table> </div> <div data-section-id="2662"> <h3 id="docs-internal-guid-11b58e93-7fff-dcee-8703-202f7b3743bb" style="line-height: 1.38; margin-top: 14pt; margin-bottom: 4pt;"><strong style="background-color:transparent; color:#000000; font-family:arial; font-size:13pt; font-style:normal; font-variant:normal; font-weight:700; text-decoration:none; vertical-align:baseline; white-space:pre-wrap"><a data-anchor-id="8088" id="loc-receiving-credit" name="loc-receiving-credit"></a>Receiving credit</strong></h3> <p style="line-height: 1.38; margin-top: 12pt; margin-bottom: 12pt;">In choosing to volunteer as a peer reviewer for PLOS, you are helping to support free and open access to rigorous research. We couldn’t be more grateful!</p> <table class="table-basic"> <tbody> <tr> </tr> <tr> <td style="vertical-align: top"> <div style="width: 70px;"><img alt="" class="img-default" src="/plospathogens/indirect/5a34c52c36cef19765246301f5152df1f67809196cf615ca33b23799d4cfe6fd"> </div></td> <td><p style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;"><strong style="background-color:transparent; color:#000000; font-family:arial; font-size:11pt; font-style:normal; font-variant:normal; font-weight:700; text-decoration:none; vertical-align:baseline; white-space:pre-wrap">Reviewer Credit with ORCID and Publons</strong></p><p style="line-height: 1.2; margin-top: 0pt; margin-bottom: 0pt;">Link your PLOS reviewer account to your ORCID or Publons record. Set up syncing to have reviewer activity automatically posted to your ORCID profile review activity. This record will confirm that you completed a review for the journal, but won’t publish the content of your review.</p></td> </tr> </tbody> </table> </div> <div data-section-id="2353"> <div style=" width: 100%; text-align: center; "> <h4 style=" text-align: center; display: inline-block; "><a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://www.editorialmanager.com/ppathogens/default.aspx" style=" display: block; width: 250px; background: #D7DF23; color: #ffffff; border: 1px solid #D7DF23; padding: 17px; border-radius: 5px; margin: 40px; ">Submit Your Review Now</a></h4> <h4 style=" text-align: center; display: inline-block; "><a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://reviewers.plos.org/" style=" display: block; width: 250px; background: #D7DF23; color: #ffffff; border: 1px solid #D7DF23; padding: 17px; border-radius: 5px; margin: 40px; ">Learn About Peer Review</a></h4> </div> </div> <div data-section-id="2362"> <h2><a data-anchor-id="7864" id="loc-what-to-assess" name="loc-what-to-assess"></a>What to Assess</h2> <p>To be eligible for publication manuscripts must meet our <a data-parent-id="1" href="https://journals-plos-org.translate.goog/plospathogens/s/journal-information?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#loc-criteria-for-publication">criteria for publication</a> and comply with our <a href="https://journals-plos-org.translate.goog/plospathogens/s/editorial-and-publishing-policies?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">editorial and publishing policies</a>. The following guidance relates to articles reporting the results of original research. If you are reviewing another article type see the <a href="https://journals-plos-org.translate.goog/plospathogens/s/other-article-types?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">other article types page</a> and check your invitation letter for guidance on what to consider in your review.</p> </div> <div data-section-id="417"> <h3><a id="loc-criteria-for-publication" name="loc-criteria-for-publication" data-anchor-id="7870"></a>Criteria for publication</h3> <p>In addition to being ethically conducted and scientifically valid, research published in <em>PLOS Pathogens</em> should fulfill each of the following criteria:</p> <ol> <li>Originality</li> <li>High importance to researchers in the field</li> <li>High importance and broad interest to the community of researchers studying pathogens and pathogen-host interactions</li> <li>Rigorous methodology</li> <li>Substantial evidence for its conclusions</li> </ol> </div> <div data-section-id="2364"> <h2><a data-anchor-id="7873" id="loc-writing-the-review" name="loc-writing-the-review"></a>Writing the review</h2> <p>The purpose of the review is to provide the editors with an expert opinion regarding the validity and quality of the manuscript under consideration. The review should also supply authors with explicit feedback on how to improve their papers so that they will be acceptable for publication in <em><i>PLOS Pathogens</i></em>. As you write, consider the following points:</p> </div> <div data-section-id="877"> <ul> <li>What are the main claims of the paper and how significant are they for the discipline?</li> <li>Are these claims novel? If not, which published articles weaken the claims of originality of this one?</li> <li>Are the claims properly placed in the context of the previous literature? Have the authors treated the literature fairly?</li> <li>Do the data and analyses fully support the claims? If not, what other evidence is required?</li> <li>Would additional work improve the paper? How much better would the paper be if this work were performed and how difficult would it be to do this work?</li> <li><em><i>PLOS Pathogens</i></em> encourages authors to publish detailed protocols and algorithms as supporting information online. Do any particular methods used in the manuscript warrant such treatment? If a protocol is already provided, for example for a randomized controlled trial, are there any important deviations from it? If so, have the authors explained adequately why the deviations occurred?</li> <li>Are original data deposited in appropriate repositories and accession/version numbers provided for genes, proteins, mutants, diseases, etc.?</li> <li>Does the study conform to any <a data-parent-id="14" href="https://journals-plos-org.translate.goog/plospathogens/s/best-practices-in-research-reporting?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB#loc-reporting-guidelines-for-specific-research-resources-and-study-types">relevant guidelines</a> such as CONSORT, MIAME, QUORUM, STROBE, and the <a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://www.sanger.ac.uk/wp-content/uploads/fortlauderdalereport.pdf">Fort Lauderdale agreement</a>?</li> <li>Are details of the methodology sufficient to allow the experiments to be reproduced?</li> <li>Is any software created by the authors freely available?</li> <li>Is the manuscript well organized and written clearly enough to be accessible to non-specialists?</li> <li>Would you recommend the author seek the services of a professional science writer? If this is the case, please alert the journal office by email.</li> <li>Does the paper use standardized scientific nomenclature and abbreviations? If not, are these explained at the first usage?</li> <li>Does this manuscript describe experiments using a select agent or toxin? <a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://www.selectagents.gov/SelectAgentsandToxinsList.html">See a complete list</a>.</li> <li>Is it your opinion that this manuscript contains an <a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://grants.nih.gov/grants/guide/notice-files/NOT-OD-13-107.html">NIH-defined experiment of Dual Use concern</a>?</li> </ul> </div> <div data-section-id="2365"> <p>Although confidential comments to the editors are respected, any remarks that might help to strengthen the paper should be directed to the authors themselves.</p> </div> <div data-section-id="2367"> <h3><a id="loc-revisions" name="loc-revisions" data-anchor-id="7874"></a>Revisions</h3> <p>We often ask the original reviewers to evaluate revised manuscripts and the authors’ response to reviewer comments. We hope that you’ll make yourself available for re-review and questions from the editors.</p> <h3><a id="loc-editing-reviewers-reports" name="loc-editing-reviewers-reports" data-anchor-id="7875"></a>Editing reviewers’ reports</h3> <p>The editors and PLOS staff will not change any reviewer comments that are intended for authors to read, except with reviewer approval prior to the decision letter being sent. For example, we may request changes if language is deemed inappropriate for professional communication, or if the comments contain information considered confidential, such as competing interest declarations.</p> </div> <div data-section-id="383"> <h2><a data-anchor-id="7876" id="loc-the-editorial-process" name="loc-the-editorial-process"></a>The Editorial Process</h2> <h3><a data-anchor-id="7877" id="loc-decision-process" name="loc-decision-process"></a>Decision process</h3> <p>The editors make the final decision on whether to publish each submission based on the reviewers’ comments, the <em><i>PLOS Pathogens</i></em>&nbsp;<a data-parent-id="undefined" href="https://journals-plos-org.translate.goog/plospathogens/s/criteria-for-publication?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">criteria for publication</a>, and their own assessment of the manuscript.</p> <h3><a data-anchor-id="7878" id="loc-conflicting-reviews" name="loc-conflicting-reviews"></a>Conflicting reviews</h3> <p>If reviewers appear to disagree fundamentally, the editors may choose to share all the reviews with each of the reviewers and request additional comments that may help the editors to reach a decision. Decisions are not necessarily made according to majority rule. Experts may disagree, and it is the job of the Editor to make a decision. Editors evaluate reviewer recommendations and comments alongside comments by the authors and material that may not have been made available to reviewers. Please know that your recommendation has been duly considered and your service is appreciated, even if the final decision does not accord with your review.</p> <p><a href="https://journals-plos-org.translate.goog/plospathogens/s/editorial-and-peer-review-process?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">More on our Editorial Process</a>.</p> </div> <div data-section-id="391"> <h2><a data-anchor-id="7848" id="loc-help" name="loc-help"></a>Help</h2> <p>For more tips on peer review go to the <a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://plos.org/resources/for-reviewers/">Peer Review Center</a>, and sign up to the <a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://plos.org/writing-peer-review-toolbox-sign-up/">Peer Review Toolbox.</a></p> <p>If you have questions or concerns about the manuscript you are reviewing, or if you need assistance submitting the review, please email us <a href="mailto:plospathogens@plos.org?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB">plospathogens@plos.org</a>.</p> </div> </article> </div> <script defer src="/resource/js/components/scroll.js" type="text/javascript"></script> <script defer src="/resource/js/components/floating_nav.js" type="text/javascript"></script> <script defer src="/resource/js/pages/site_content.js" type="text/javascript"></script> </main> <footer id="pageftr"> <div class="row"> <div class="block x-small"> <ul class="nav nav-secondary"> <li class="ftr-header"><a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://plos.org/our-journals/">Publications</a></li> <li><a href="https://journals-plos-org.translate.goog/plosbiology/?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB" id="ftr-bio">PLOS Biology</a></li> <li><a href="https://journals-plos-org.translate.goog/climate/?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB" id="ftr-climate">PLOS Climate</a></li> <li><a href="https://journals-plos-org.translate.goog/complexsystems/?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB" id="ftr-complex-systems">PLOS Complex Systems</a></li> <li><a href="https://journals-plos-org.translate.goog/ploscompbiol/?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB" id="ftr-compbio">PLOS Computational Biology</a></li> <li><a href="https://journals-plos-org.translate.goog/digitalhealth/?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB" id="ftr-digitalhealth">PLOS Digital Health</a></li> <li><a href="https://journals-plos-org.translate.goog/plosgenetics/?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB" id="ftr-gen">PLOS Genetics</a></li> <li><a href="https://journals-plos-org.translate.goog/globalpublichealth/?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB" id="ftr-globalpublichealth">PLOS Global Public Health</a></li> </ul> </div> <div class="block x-small"> <ul class="nav nav-secondary"> <li class="ftr-header">&nbsp;</li> <li><a href="https://journals-plos-org.translate.goog/plosmedicine/?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB" id="ftr-med">PLOS Medicine</a></li> <li><a href="https://journals-plos-org.translate.goog/mentalhealth/?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB" id="ftr-mental-health">PLOS Mental Health</a></li> <li><a href="https://journals-plos-org.translate.goog/plosntds/?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB" id="ftr-ntds">PLOS Neglected Tropical Diseases</a></li> <li><a href="https://journals-plos-org.translate.goog/plosone/?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB" id="ftr-one">PLOS One</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB" id="ftr-path">PLOS Pathogens</a></li> <li><a href="https://journals-plos-org.translate.goog/sustainabilitytransformation/?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB" id="ftr-sustainabilitytransformation">PLOS Sustainability and Transformation</a></li> <li><a href="https://journals-plos-org.translate.goog/water/?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB" id="ftr-water">PLOS Water</a></li> </ul> </div> <div class="block xx-small"> <ul class="nav nav-tertiary"> <li><a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://plos.org" id="ftr-home">Home</a></li> <li><a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://blogs.plos.org" id="ftr-blog">Blogs</a></li> <li><a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://collections.plos.org/" id="ftr-collections">Collections</a></li> <li><a href="mailto:webmaster@plos.org?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB" id="ftr-feedback">Give feedback</a></li> <li><a href="https://journals-plos-org.translate.goog/plospathogens/lockss-manifest?_x_tr_sl=pl&amp;_x_tr_tl=ru&amp;_x_tr_hl=en-GB" id="ftr-lockss">LOCKSS</a></li> </ul> </div> <div class="block xx-small"> <ul class="nav nav-primary"> <li><a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://plos.org/privacy-policy" id="ftr-privacy">Privacy Policy</a></li> <li><a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://plos.org/terms-of-use" id="ftr-terms">Terms of Use</a></li> <li><a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://plos.org/advertise/" id="ftr-advertise">Advertise</a></li> <li><a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://plos.org/media-inquiries" id="ftr-media">Media Inquiries</a></li> <li><a href="https://translate.google.com/website?sl=pl&amp;tl=ru&amp;hl=en-GB&amp;u=https://plos.org/contact" id="ftr-contact">Contact</a></li> </ul> </div> </div> <div class="row"> <p><img src="/resource/img/logo-plos-footer.png" alt="PLOS" class="logo-footer"> <span class="footer-non-profit-statement">PLOS is a nonprofit 501(c)(3) corporation, #C2354500, based in California, US</span></p> <div class="block"> </div> </div> <script src="/resource/js/global.js" type="text/javascript"></script> </footer> <script>function gtElInit() {var lib = new google.translate.TranslateService();lib.translatePage('pl', 'ru', function () {});}</script> <script src="https://translate.google.com/translate_a/element.js?cb=gtElInit&amp;hl=en-GB&amp;client=wt" type="text/javascript"></script> </body> </html>

Pages: 1 2 3 4 5 6 7 8 9 10