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Gene Therapy Legislation in Norway

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The NoMA is the national, regulatory authority for new and existing medicines and the supply chain. The agency is responsible for supervising the production, trials and marketing of medicines. It approves medicines and monitors their use, and ensures cost-efficient, effective and well-documented use of medicines. The inspectorate also supervises the supply-chain. NOMA also regulate prices and trade conditions for pharmacies.</p> <p>The GMO aspects of clinical trials with medicinal products for human use containing or consisting of GMOs can fall under either the contained use or the deliberate release frameworks, depending on the product. A decision is taken on a case-by case basis. For example, ex-vivo stable modification of patients cells is considered under contained use and, due to the absence of risk of spreading after transfusion of the GM-cells back to the patients, patients may leave the clinic after treatment.</p> <p>On the other hand, persisting, circulating GMO medicinal products may require an approval under deliberate release. This will partly depend on the condition to be treated. Thus, long time hospitalization (as for cancers) may be assessed under contained use, since the GMO will be eliminated by/from the body within the time the patient is in hospital. In contrast, when the treatment only involves a short visit (as for receiving a GMO vaccine), the deliberate release framework applies, due to the risk of spreading the GMO when leaving the site after vaccination. The applications to seek authorization under clinical trials and under GMO frameworks are not linked (i.e. the applicant can decide the timing of the submission of the GMO application).</p> <p>Additional information can be found at: <br> - <a href="https://helsedirektoratet.no/bioteknologi/genterapi" target="_blank">https://helsedirektoratet.no/bioteknologi/genterapi</a><br> - <a href="https://helsedirektoratet.no/lover/genteknologiloven" target="_blank">https://helsedirektoratet.no/lover/genteknologiloven</a><br> - <a href="https://www.regjeringen.no/en/dokumenter/gene-technology-act/id173031/" target="_blank">https://www.regjeringen.no/en/dokumenter/gene-technology-act/id173031/</a><br> - <a href="https://www.legemiddelverket.no/" target="_blank">Norwegian Medicines Agency (NoMA)</a><br> - <a href="https://www.regjeringen.no/en/dep/md.html?id=668" target="_blank">Ministry of the Environment</a><br> - <a href="https://www.regjeringen.no/en/dep/hod.html?id=421" target="_blank">Ministry of Health and Care Services</a> </p> <p><b>Application forms to seek authorisation for the GMO aspects</b><br> <i>Contained use:</i><br> Application form for approval of the contained site area:<br> <a href="https://helsedirektoratet.no/Documents/Genteknologi/GMM_godkjenning_laboratorier.doc" target="_blank">https://helsedirektoratet.no/Documents/Genteknologi/GMM_godkjenning_laboratorier.doc</a><br> Notification form:<br> <a href="https://helsedirektoratet.no/Documents/Genteknologi/GMM_melding_eller_soknad.docx" target="_blank">https://helsedirektoratet.no/Documents/Genteknologi/GMM_melding_eller_soknad.docx</a></p> <p><i>Deliberate release (Directive 2001/18 – Part B):</i><br> There is no standardized form. The Applicant must submit an application for deliberate release of GMO according to the Gene Technology Act and to part B of Directive 2001/18/EC on the deliberate release of GMO into the environment. The application must include an impact assessment of the GMO to be used in a clinical trial. The content of the impact assessment is given in Regulations relating to impact assessment pursuant to the Gene Technology Act (<a href="https://www.regjeringen.no/en/dokumenter/impact-assessment/id440455/" target="_blank">https://www.regjeringen.no/en/dokumenter/impact-assessment/id440455/</a>). A summary (SNIF) according to part B of directive 2001/18/EC on the deliberate release into the environment of GMO, which is added to a publically available EU register, must also be provided. </p> <p><b>Public consultation</b><br> The Norwegian Environment Agency may conduct a public consultation on GMO aspects pursuant to the Gene Technology Act. However, public consultations are not conducted as a standard with regards to applications for experimental releases such as clinical trials, but rather evaluated on a case by case basis. If a public consultation is deemed necessary, the consultation takes place via the official public consultation's website of the Norwegian Environment Agency (<a href="https://www.miljodirektoratet.no/no/Horinger/GMO/" target="_blank">https://www.miljodirektoratet.no/no/Horinger/GMO/</a>). The period of the consultation is restricted to 30 days.</p> <hr><p><b>National authorities involved</b></p> <p><i>Authorization of clinical trials:</i><br> The Norwegian Medicines Agency<br> Postboks 6167 Etterstad, 0602 Oslo.<br> <joomla-hidden-mail is-link="1" is-email="1" first="cG9zdA==" last="bm9tYS5ubw==" text="cG9zdEBub21hLm5v" base="" >This email address is being protected from spambots. You need JavaScript enabled to view it.</joomla-hidden-mail><br> Queries on submissions can be sent to: <joomla-hidden-mail is-link="1" is-email="1" first="a2x1dA==" last="bm9tYS5ubw==" text="a2x1dEBub21hLm5v" base="" >This email address is being protected from spambots. You need JavaScript enabled to view it.</joomla-hidden-mail> </p> <p><i>Authorisation of GMO aspects:</i><br> The Norwegian Directorate for Health (for contained use)<br> Dept. of Biotechnology and Health Legislation, P.O. Box 7000 St. Olavs plass, N-0130 Oslo.</p> <p>The Norwegian Environment Agency (for deliberate release)<br> P.O.Box 5672 Torgarden, NO-7485 Trondheim.<br> e-mail: <joomla-hidden-mail is-link="1" is-email="1" first="cG9zdA==" last="bWlsam9kaXIubm8=" text="cG9zdEBtaWxqb2Rpci5ubw==" base="" >This email address is being protected from spambots. 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