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id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">American cell biologist</div> <p class="mw-empty-elt"> </p> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox biography vcard"><tbody><tr><th colspan="2" class="infobox-above" style="font-size:125%;"><div class="fn">Paul Negulescu</div></th></tr><tr><th scope="row" class="infobox-label">Born</th><td class="infobox-data"><div style="display:inline" class="nickname">Paul Adrian Negulescu<sup id="cite_ref-thesis_2-0" class="reference"><a href="#cite_note-thesis-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></div><br /><div style="display:inline" class="birthplace"><a href="/wiki/San_Francisco" title="San Francisco">San Francisco</a><sup id="cite_ref-autobio_1-2" class="reference"><a href="#cite_note-autobio-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></div></td></tr><tr><th scope="row" class="infobox-label">Education</th><td class="infobox-data"><a href="/wiki/University_of_California,_Berkeley" title="University of California, Berkeley">University of California, Berkeley</a> (<a href="/wiki/Bachelor_of_Science" title="Bachelor of Science">BSc</a>, <a href="/wiki/Doctor_of_Philosophy" title="Doctor of Philosophy">PhD</a>)<sup id="cite_ref-autobio_1-3" class="reference"><a href="#cite_note-autobio-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label">Known for</th><td class="infobox-data">Research of <a href="/wiki/Cystic_fibrosis" title="Cystic fibrosis">cystic fibrosis</a></td></tr><tr><th scope="row" class="infobox-label">Awards</th><td class="infobox-data"><a href="/wiki/Warren_Alpert_Foundation_Prize" title="Warren Alpert Foundation Prize">Warren Alpert Foundation Prize</a> (2018)<br /> <a href="/wiki/Shaw_Prize" title="Shaw Prize">Shaw Prize in Life Science & Medicine</a> (2022)<br /><a href="/wiki/Wiley_Prize" title="Wiley Prize">Wiley Prize</a> (2023) <br /><a href="/wiki/Breakthrough_Prize_in_Life_Sciences" title="Breakthrough Prize in Life Sciences">Breakthrough Prize in Life Sciences</a> (2024)</td></tr><tr><td colspan="2" class="infobox-full-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><b>Scientific career</b></td></tr><tr><th scope="row" class="infobox-label">Fields</th><td class="infobox-data category"><a href="/wiki/Cell_biology" title="Cell biology">Cell biology</a></td></tr><tr><th scope="row" class="infobox-label">Institutions</th><td class="infobox-data"><a href="/wiki/University_of_California,_Irvine" title="University of California, Irvine">University of California, Irvine</a> <br /> <a href="/wiki/Aurora_Biosciences" title="Aurora Biosciences">Aurora Biosciences</a> <br /> <a href="/wiki/Vertex_Pharmaceuticals" title="Vertex Pharmaceuticals">Vertex Pharmaceuticals</a><sup id="cite_ref-autobio_1-0" class="reference"><a href="#cite_note-autobio-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Thesis" title="Thesis">Thesis</a></th><td class="infobox-data"><i><a rel="nofollow" class="external text" href="https://search.library.berkeley.edu/permalink/01UCS_BER/s4lks2/cdi_proquest_journals_303683972">The role and regulation of intracellular calcium during stimulus-secretion coupling in the parietal cell</a></i> <span style="font-size:97%;">(1988)</span></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Doctoral_advisor" title="Doctoral advisor">Doctoral advisor</a></th><td class="infobox-data">Terry Machen<sup id="cite_ref-autobio_1-1" class="reference"><a href="#cite_note-autobio-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></td></tr><tr style="display:none"><td colspan="2"> </td></tr></tbody></table> <p><b>Paul Adrian Negulescu</b> is an American–<a href="/wiki/Romanians" title="Romanians">Romanian</a> <a href="/wiki/Cell_biology" title="Cell biology">cell biologist</a>. He is a Senior Vice President at American <a href="/wiki/Pharmaceutical_industry" title="Pharmaceutical industry">pharmaceutical company</a> <a href="/wiki/Vertex_Pharmaceuticals" title="Vertex Pharmaceuticals">Vertex Pharmaceuticals</a>. He received the 2022 <a href="/wiki/Shaw_Prize" title="Shaw Prize">Shaw Prize in Life science and medicine</a>, together with <a href="/wiki/Michael_J._Welsh_(biologist)" title="Michael J. Welsh (biologist)">Michael J. Welsh</a>, for their work that uncovered the <a href="/wiki/Etiology" title="Etiology">etiology</a> of <a href="/wiki/Cystic_fibrosis" title="Cystic fibrosis">cystic fibrosis</a> and developed effective <a href="/wiki/Medication" title="Medication">medications</a>.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Early_life_and_education">Early life and education</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Paul_Negulescu&action=edit&section=1" title="Edit section: Early life and education"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Negulescu was born in <a href="/wiki/San_Francisco" title="San Francisco">San Francisco</a> to <a href="/wiki/Immigrant_generations#First_generation" title="Immigrant generations">first-generation immigrants</a> from <a href="/wiki/Romania" title="Romania">Romania</a>. His father was a <a href="/wiki/Surgery" title="Surgery">surgeon</a>,<sup id="cite_ref-autobio_1-4" class="reference"><a href="#cite_note-autobio-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> and his grandfather, <a href="/wiki/Constantin_Vi%C8%99oianu" title="Constantin Vișoianu">Constantin Vișoianu</a>, was a former <a href="/wiki/Ministry_of_Foreign_Affairs_(Romania)" title="Ministry of Foreign Affairs (Romania)">Minister of Foreign Affairs</a> of Romania.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> He has a brother.<sup id="cite_ref-autobio_1-5" class="reference"><a href="#cite_note-autobio-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p><p>Thanks to his childhood experience, he initially wanted to graduate with <a href="/wiki/History" title="History">history</a> from the <a href="/wiki/University_of_California,_Berkeley" title="University of California, Berkeley">University of California, Berkeley</a>. A third-year <a href="/wiki/Physiology" title="Physiology">physiology</a> class taught by <a href="/wiki/Roger_Y._Tsien" title="Roger Y. Tsien">Roger Y. Tsien</a> had a great influence on Negulescu, who eventually graduated with a <a href="/wiki/Double_degree" class="mw-redirect" title="Double degree">dual degree</a> in history and physiology in 1986. He then went on and studied <a href="/wiki/Doctor_of_Philosophy" title="Doctor of Philosophy">PhD</a> in physiology under Terry Machen, completing it in 1990.<sup id="cite_ref-autobio_1-6" class="reference"><a href="#cite_note-autobio-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Career">Career</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Paul_Negulescu&action=edit&section=2" title="Edit section: Career"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Negulescu started his career as a <a href="/wiki/Postdoctoral_researcher" title="Postdoctoral researcher">postdoctoral researcher</a> at the <a href="/wiki/University_of_California,_Berkeley" title="University of California, Berkeley">University of California, Berkeley</a> and under Michael Cahalan at the <a href="/wiki/University_of_California,_Irvine" title="University of California, Irvine">University of California, Irvine</a>. He was planning to move to the <a href="/wiki/University_of_Connecticut" title="University of Connecticut">University of Connecticut</a> when <a href="/wiki/Roger_Y._Tsien" title="Roger Y. Tsien">Roger Y. Tsien</a> asked him to join a <a href="/wiki/Startup_company" title="Startup company">startup company</a> he was forming called <a href="/wiki/Aurora_Biosciences" title="Aurora Biosciences">Aurora Biosciences</a>.<sup id="cite_ref-autobio_1-7" class="reference"><a href="#cite_note-autobio-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Negulescu joined Aurora Biosciences in 1996 as one of the first employees.<sup id="cite_ref-warrenalpert_7-0" class="reference"><a href="#cite_note-warrenalpert-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> He became Senior Vice President of Discovery Biology in 1999. When <a href="/wiki/Vertex_Pharmaceuticals" title="Vertex Pharmaceuticals">Vertex Pharmaceuticals</a> acquired Aurora Biosciences in 2001,<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> he was appointed Senior Vice President of Research.<sup id="cite_ref-autobio_1-8" class="reference"><a href="#cite_note-autobio-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Negulescu has been leading the <a href="/wiki/San_Diego" title="San Diego">San Diego</a> Research Center of Vertex Pharmaceuticals since 2003.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Research">Research</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Paul_Negulescu&action=edit&section=3" title="Edit section: Research"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Negulescu's research focuses on the therapy of <a href="/wiki/Cystic_fibrosis" title="Cystic fibrosis">cystic fibrosis</a>. Cystic fibrosis can be caused by any of the thousands of identified <a href="/wiki/Mutation" title="Mutation">mutations</a> in the <a href="/wiki/Cystic_fibrosis_transmembrane_conductance_regulator" title="Cystic fibrosis transmembrane conductance regulator">CFTR</a> protein, an <a href="/wiki/Ion_channel" title="Ion channel">ion channel</a> that allows <a href="/wiki/Chloride" title="Chloride">chloride ions</a> to pass through. These mutations have been classified into Class I to V, with Class III mutations causing defective channel gates in CFTR despite normal expression of the protein.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Via <a href="/wiki/High-throughput_screening" title="High-throughput screening">high-throughput screening</a>, his team at <a href="/wiki/Vertex_Pharmaceuticals" title="Vertex Pharmaceuticals">Vertex Pharmaceuticals</a> discovered <a href="/wiki/Ivacaftor" title="Ivacaftor">ivacaftor</a>, a <a href="/wiki/Small_molecule" title="Small molecule">small-molecule</a> <a href="/wiki/Potentiator" title="Potentiator">potentiator</a> that increases the probability that mutated CFTR gates will open.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> Ivacaftor was approved by the <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA) for cystic fibrosis patients with one specific Class III mutation in 2012, and has since been approved for mutation classes as well.<sup id="cite_ref-annurev_13-0" class="reference"><a href="#cite_note-annurev-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> Of note, the expanded approval in 2017 was based solely on <i><a href="/wiki/In_vitro" title="In vitro">in vitro</a></i> data, due to the small number of patients carrying those rare mutations making <a href="/wiki/Clinical_trial" title="Clinical trial">clinical trials</a> impossible.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p><p>Negulescu also led the discovery of another cystic fibrosis drug, <a href="/wiki/Lumacaftor" title="Lumacaftor">lumacaftor</a>, which is known as a "corrector" as it acts as a <a href="/wiki/Chaperone_(protein)" title="Chaperone (protein)">chaperone</a> to help the CFTR protein fold correctly.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Thus, it can be used in patients with Class II mutations, which create <a href="/wiki/Misfold" class="mw-redirect" title="Misfold">misfolded</a> CFTR protein that cannot reaching the <a href="/wiki/Cell_membrane" title="Cell membrane">cell surface</a>.<sup id="cite_ref-annurev_13-1" class="reference"><a href="#cite_note-annurev-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> The most common Class II mutation is F508del.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> Again with high-throughput screening, Negulescu and his team found that lumacaftor can correct F508del-mutated CFTR protein.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> It was later found that the drug was not effective enough when administered on its own,<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> but was so when administered together with ivacaftor.<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> The FDA approved this drug combination in 2015.<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> Further research led to the discovery of <a href="/wiki/Tezacaftor" title="Tezacaftor">tezacaftor</a> and <a href="/wiki/Elexacaftor" title="Elexacaftor">elexacaftor</a>, 2 other correctors of the CFTR protein.<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> The triple combination <a href="/wiki/Elexacaftor/tezacaftor/ivacaftor" title="Elexacaftor/tezacaftor/ivacaftor">elexacaftor/tezacaftor/ivacaftor</a> was approved by the FDA in 2019.<sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Honors_and_awards">Honors and awards</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Paul_Negulescu&action=edit&section=4" title="Edit section: Honors and awards"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>2018 - <a href="/wiki/Warren_Alpert_Foundation_Prize" title="Warren Alpert Foundation Prize">Warren Alpert Foundation Prize</a><sup id="cite_ref-warrenalpert_7-1" class="reference"><a href="#cite_note-warrenalpert-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup></li> <li>2022 - <a href="/wiki/Shaw_Prize" title="Shaw Prize">Shaw Prize in Life Science & Medicine</a><sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup></li> <li>2023 - <a href="/wiki/Wiley_Prize" title="Wiley Prize">Wiley Prize</a><sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup></li> <li>2024 - <a href="/wiki/Breakthrough_Prize_in_Life_Sciences" title="Breakthrough Prize in Life Sciences">Breakthrough Prize in Life Sciences</a><sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup></li></ul> <div class="mw-heading mw-heading2"><h2 id="Personal_life">Personal life</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Paul_Negulescu&action=edit&section=5" title="Edit section: Personal life"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Negulescu met his wife, Debbie, during his time at the <a href="/wiki/University_of_California,_Irvine" title="University of California, Irvine">University of California, Irvine</a>.<sup id="cite_ref-autobio_1-9" class="reference"><a href="#cite_note-autobio-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a 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Bennett">Charles Bennett</a>, <a href="/wiki/Lyman_Page" title="Lyman Page">Lyman Page</a> and <a href="/wiki/David_Spergel" title="David Spergel">David Spergel</a> (2010)</li> <li><a href="/wiki/Enrico_Costa_(physicist)" title="Enrico Costa (physicist)">Enrico Costa</a> and <a href="/wiki/Gerald_J._Fishman" title="Gerald J. Fishman">Gerald Fishman</a> (2011)</li> <li><a href="/wiki/David_C._Jewitt" title="David C. Jewitt">David C. Jewitt</a> and <a href="/wiki/Jane_Luu" title="Jane Luu">Jane Luu</a> (2012)</li> <li><a href="/wiki/Steven_Balbus" title="Steven Balbus">Steven Balbus</a> and <a href="/wiki/John_F._Hawley" title="John F. Hawley">John F. Hawley</a> (2013)</li> <li><a href="/wiki/Daniel_Eisenstein" title="Daniel Eisenstein">Daniel Eisenstein</a>, <a href="/wiki/Shaun_Cole" title="Shaun Cole">Shaun Cole</a> and <a href="/wiki/John_A._Peacock" title="John A. Peacock">John A. Peacock</a> (2014)</li> <li><a href="/wiki/William_J._Borucki" title="William J. Borucki">William J. 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Stone</a> (2019)</li> <li><a href="/wiki/Roger_Blandford" title="Roger Blandford">Roger Blandford</a> (2020)</li> <li><a href="/wiki/Victoria_Kaspi" title="Victoria Kaspi">Victoria Kaspi</a> and <a href="/wiki/Chryssa_Kouveliotou" title="Chryssa Kouveliotou">Chryssa Kouveliotou</a> (2021)</li> <li><a href="/wiki/Lennart_Lindegren" title="Lennart Lindegren">Lennart Lindegren</a> and <a href="/wiki/Michael_Perryman" title="Michael Perryman">Michael Perryman</a> (2022)</li> <li><a href="/wiki/Matthew_Bailes" title="Matthew Bailes">Matthew Bailes</a>, <a href="/wiki/Duncan_Lorimer" title="Duncan Lorimer">Duncan Lorimer</a> and <a href="/wiki/Maura_McLaughlin" title="Maura McLaughlin">Maura McLaughlin</a> (2023)</li> <li><a href="/wiki/Shrinivas_R._Kulkarni" class="mw-redirect" title="Shrinivas R. Kulkarni">Shrinivas R. 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S. Campbell</a> and <a href="/wiki/Shinya_Yamanaka" title="Shinya Yamanaka">Shinya Yamanaka</a> (2008)</li> <li><a href="/wiki/Douglas_L._Coleman" title="Douglas L. Coleman">Douglas Coleman</a> and <a href="/wiki/Jeffrey_M._Friedman" title="Jeffrey M. Friedman">Jeffrey Friedman</a> (2009)</li> <li><a href="/wiki/David_Julius" title="David Julius">David Julius</a> (2010)</li> <li><a href="/wiki/Jules_A._Hoffmann" title="Jules A. Hoffmann">Jules Hoffmann</a>, <a href="/wiki/Ruslan_Medzhitov" title="Ruslan Medzhitov">Ruslan Medzhitov</a> and <a href="/wiki/Bruce_Beutler" title="Bruce Beutler">Bruce Beutler</a> (2011)</li> <li><a href="/wiki/Franz-Ulrich_Hartl" title="Franz-Ulrich Hartl">Franz-Ulrich Hartl</a> and <a href="/wiki/Arthur_L._Horwich" title="Arthur L. Horwich">Arthur L. Horwich</a> (2012)</li> <li><a href="/wiki/Jeffrey_C._Hall" title="Jeffrey C. Hall">Jeffrey C. Hall</a>, <a href="/wiki/Michael_Rosbash" title="Michael Rosbash">Michael Rosbash</a> and <a href="/wiki/Michael_W._Young" title="Michael W. Young">Michael W. Young</a> (2013)</li> <li><a href="/wiki/Kazutoshi_Mori" title="Kazutoshi Mori">Kazutoshi Mori</a> and <a href="/wiki/Peter_Walter" title="Peter Walter">Peter Walter</a> (2014)</li> <li><a href="/wiki/Bonnie_Bassler" title="Bonnie Bassler">Bonnie Bassler</a> and <a href="/wiki/Everett_Peter_Greenberg" title="Everett Peter Greenberg">Everett Peter Greenberg</a> (2015)</li> <li><a href="/wiki/Adrian_Bird" title="Adrian Bird">Adrian Bird</a> and <a href="/wiki/Huda_Zoghbi" title="Huda Zoghbi">Huda Zoghbi</a> (2016)</li> <li><a href="/wiki/Ian_R._Gibbons" title="Ian R. Gibbons">Ian R. Gibbons</a> and <a href="/wiki/Ronald_Vale" title="Ronald Vale">Ronald Vale</a> (2017)</li> <li><a href="/wiki/Mary-Claire_King" title="Mary-Claire King">Mary-Claire King</a> (2018)</li> <li><a href="/wiki/Maria_Jasin" title="Maria Jasin">Maria Jasin</a> (2019)</li> <li><a href="/wiki/Gero_Miesenb%C3%B6ck" title="Gero Miesenböck">Gero Miesenböck</a>, <a href="/wiki/Peter_Hegemann" title="Peter Hegemann">Peter Hegemann</a> and <a href="/wiki/Georg_Nagel" title="Georg Nagel">Georg Nagel</a> (2020)</li> <li><a href="/wiki/Scott_D._Emr" title="Scott D. Emr">Scott D. Emr</a> (2021)</li> <li><a class="mw-selflink selflink">Paul A. Negulescu</a> and <a href="/wiki/Michael_J._Welsh_(biologist)" title="Michael J. Welsh (biologist)">Michael J. Welsh</a> (2022)</li> <li><a href="/wiki/Patrick_Cramer" title="Patrick Cramer">Patrick Cramer</a> and <a href="/wiki/Eva_Nogales" title="Eva Nogales">Eva Nogales</a> (2023)</li> <li><a href="/wiki/Stuart_H._Orkin" class="mw-redirect" title="Stuart H. Orkin">Stuart H. Orkin</a> and <a href="/wiki/Swee_Lay_Thein" title="Swee Lay Thein">Swee Lay Thein</a> (2024)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background:#d3d3d3;">Mathematical<br />science</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Shiing-Shen_Chern" title="Shiing-Shen Chern">Shiing-Shen Chern</a> (2004)</li> <li><a href="/wiki/Andrew_Wiles" title="Andrew Wiles">Andrew Wiles</a> (2005)</li> <li><a href="/wiki/David_Mumford" title="David Mumford">David Mumford</a> and <a href="/wiki/Wu_Wenjun" title="Wu Wenjun">Wentsun Wu</a> (2006)</li> <li><a href="/wiki/Robert_Langlands" title="Robert Langlands">Robert Langlands</a> and <a href="/wiki/Richard_Taylor_(mathematician)" title="Richard Taylor (mathematician)">Richard Taylor</a> (2007)</li> <li><a href="/wiki/Vladimir_Arnold" title="Vladimir Arnold">Vladimir Arnold</a> and <a href="/wiki/Ludvig_Faddeev" title="Ludvig Faddeev">Ludwig Faddeev</a> (2008)</li> <li><a href="/wiki/Simon_Donaldson" title="Simon Donaldson">Simon Donaldson</a> and <a href="/wiki/Clifford_Taubes" title="Clifford Taubes">Clifford Taubes</a> (2009)</li> <li><a href="/wiki/Jean_Bourgain" title="Jean Bourgain">Jean Bourgain</a> (2010)</li> <li><a href="/wiki/Demetrios_Christodoulou" title="Demetrios Christodoulou">Demetrios Christodoulou</a> and <a href="/wiki/Richard_S._Hamilton" title="Richard S. Hamilton">Richard S. Hamilton</a> (2011)</li> <li><a href="/wiki/Maxim_Kontsevich" title="Maxim Kontsevich">Maxim Kontsevich</a> (2012)</li> <li><a href="/wiki/David_Donoho" title="David Donoho">David Donoho</a> (2013)</li> <li><a href="/wiki/George_Lusztig" title="George Lusztig">George Lusztig</a> (2014)</li> <li><a href="/wiki/Gerd_Faltings" title="Gerd Faltings">Gerd Faltings</a> and <a href="/wiki/Henryk_Iwaniec" title="Henryk Iwaniec">Henryk Iwaniec</a> (2015)</li> <li><a href="/wiki/Nigel_Hitchin" title="Nigel Hitchin">Nigel Hitchin</a> (2016)</li> <li><a href="/wiki/J%C3%A1nos_Koll%C3%A1r" title="János Kollár">János Kollár</a> and <a href="/wiki/Claire_Voisin" title="Claire Voisin">Claire Voisin</a> (2017)</li> <li><a href="/wiki/Luis_Caffarelli" title="Luis Caffarelli">Luis Caffarelli</a> (2018)</li> <li><a href="/wiki/Michel_Talagrand" title="Michel Talagrand">Michel Talagrand</a> (2019)</li> <li><a href="/wiki/Alexander_Beilinson" title="Alexander Beilinson">Alexander Beilinson</a> and <a href="/wiki/David_Kazhdan" title="David Kazhdan">David Kazhdan</a> (2020)</li> <li><a href="/wiki/Jean-Michel_Bismut" title="Jean-Michel Bismut">Jean-Michel Bismut</a> and <a href="/wiki/Jeff_Cheeger" title="Jeff Cheeger">Jeff Cheeger</a> (2021)</li> <li><a href="/wiki/Noga_Alon" title="Noga Alon">Noga Alon</a> and <a href="/wiki/Ehud_Hrushovski" title="Ehud Hrushovski">Ehud Hrushovski</a> (2022)</li> <li><a href="/wiki/Vladimir_Drinfeld" title="Vladimir Drinfeld">Vladimir Drinfeld</a> and <a href="/wiki/Shing-Tung_Yau" title="Shing-Tung Yau">Shing-Tung Yau</a> (2023)</li> <li><a href="/wiki/Peter_Sarnak" title="Peter Sarnak">Peter Sarnak</a> (2024)</li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Paul_Negulescu&oldid=1230293740">https://en.wikipedia.org/w/index.php?title=Paul_Negulescu&oldid=1230293740</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Living_people" title="Category:Living people">Living people</a></li><li><a href="/wiki/Category:21st-century_American_biologists" title="Category:21st-century American biologists">21st-century American biologists</a></li><li><a href="/wiki/Category:University_of_California,_Berkeley_alumni" title="Category:University of California, Berkeley alumni">University of California, Berkeley alumni</a></li><li><a href="/wiki/Category:American_people_of_Romanian_descent" title="Category:American people of Romanian descent">American people of Romanian descent</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Hidden categories: <ul><li><a href="/wiki/Category:Articles_with_short_description" title="Category:Articles with short description">Articles with short description</a></li><li><a href="/wiki/Category:Short_description_matches_Wikidata" title="Category:Short description matches Wikidata">Short description matches Wikidata</a></li><li><a href="/wiki/Category:Use_American_English_from_October_2022" title="Category:Use American English from October 2022">Use American English from October 2022</a></li><li><a href="/wiki/Category:All_Wikipedia_articles_written_in_American_English" title="Category:All Wikipedia articles written in American English">All Wikipedia articles written in American English</a></li><li><a href="/wiki/Category:Use_mdy_dates_from_October_2022" title="Category:Use mdy dates from October 2022">Use mdy dates from October 2022</a></li><li><a href="/wiki/Category:Articles_with_hCards" title="Category:Articles with hCards">Articles with hCards</a></li><li><a href="/wiki/Category:Year_of_birth_missing_(living_people)" title="Category:Year of birth missing (living people)">Year of birth missing (living people)</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> This page was last edited on 21 June 2024, at 21:41<span class="anonymous-show"> (UTC)</span>.</li> <li id="footer-info-copyright">Text is available under the <a href="/wiki/Wikipedia:Text_of_the_Creative_Commons_Attribution-ShareAlike_4.0_International_License" title="Wikipedia:Text of the Creative Commons Attribution-ShareAlike 4.0 International License">Creative Commons Attribution-ShareAlike 4.0 License</a>; additional terms may apply. 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