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[r]" accesskey="r"><span>Perubahan terbaru</span></a></li><li id="n-Artikel-pilihan" class="mw-list-item"><a href="/wiki/Wikipedia:Artikel_pilihan/Topik"><span>Artikel pilihan</span></a></li><li id="n-currentevents" class="mw-list-item"><a href="/wiki/Portal:Peristiwa_terkini" title="Temukan informasi tentang peristiwa terkini"><span>Peristiwa terkini</span></a></li><li id="n-newpage" class="mw-list-item"><a href="/wiki/Istimewa:Halaman_baru"><span>Halaman baru</span></a></li><li id="n-randompage" class="mw-list-item"><a href="/wiki/Istimewa:Halaman_sembarang" title="Tampilkan sembarang halaman [x]" accesskey="x"><span>Halaman sembarang</span></a></li> </ul> </div> </div> <div id="p-Komunitas" class="vector-menu mw-portlet mw-portlet-Komunitas" > <div class="vector-menu-heading"> Komunitas </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-Warung-Kopi" class="mw-list-item"><a href="/wiki/Wikipedia:Warung_Kopi"><span>Warung Kopi</span></a></li><li id="n-portal" class="mw-list-item"><a href="/wiki/Portal:Komunitas" title="Tentang proyek, apa yang dapat Anda lakukan, di mana untuk mencari sesuatu"><span>Portal komunitas</span></a></li><li id="n-help" class="mw-list-item"><a href="/wiki/Bantuan:Isi" title="Tempat mencari bantuan."><span>Bantuan</span></a></li> </ul> </div> </div> <div id="p-Wikipedia" class="vector-menu mw-portlet mw-portlet-Wikipedia" > <div class="vector-menu-heading"> Wikipedia </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-aboutsite" class="mw-list-item"><a href="/wiki/Wikipedia:Perihal"><span>Tentang Wikipedia</span></a></li><li id="n-Pancapilar" class="mw-list-item"><a href="/wiki/Wikipedia:Pancapilar"><span>Pancapilar</span></a></li><li id="n-Kebijakan" class="mw-list-item"><a href="/wiki/Wikipedia:Kebijakan_dan_pedoman"><span>Kebijakan</span></a></li><li id="n-Hubungi-kami" class="mw-list-item"><a href="/wiki/Wikipedia:Hubungi_kami"><span>Hubungi kami</span></a></li><li id="n-Bak-pasir" class="mw-list-item"><a href="/wiki/Wikipedia:Bak_pasir"><span>Bak pasir</span></a></li> </ul> </div> </div> <div id="p-Bagikan" class="vector-menu mw-portlet mw-portlet-Bagikan emptyPortlet" > <div class="vector-menu-heading"> Bagikan </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </div> </div> </nav> <a href="/wiki/Halaman_Utama" class="mw-logo"> <img class="mw-logo-icon" src="/static/images/icons/wikipedia.png" alt="" aria-hidden="true" height="50" width="50"> <span class="mw-logo-container skin-invert"> <img class="mw-logo-wordmark" alt="Wikipedia" src="/static/images/mobile/copyright/wikipedia-wordmark-en.svg" style="width: 7.5em; height: 1.125em;"> <img class="mw-logo-tagline" alt="Ensiklopedia Bebas" src="/static/images/mobile/copyright/wikipedia-tagline-id.svg" width="120" height="14" style="width: 7.5em; height: 0.875em;"> </span> </a> </div> <div class="vector-header-end"> <div id="p-search" role="search" class="vector-search-box-vue vector-search-box-collapses vector-search-box-show-thumbnail vector-search-box-auto-expand-width vector-search-box"> <a href="/wiki/Istimewa:Pencarian" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only search-toggle" title="Cari di Wikipedia [f]" accesskey="f"><span class="vector-icon mw-ui-icon-search mw-ui-icon-wikimedia-search"></span> <span>Pencarian</span> </a> <div class="vector-typeahead-search-container"> <div class="cdx-typeahead-search cdx-typeahead-search--show-thumbnail cdx-typeahead-search--auto-expand-width"> <form action="/w/index.php" id="searchform" class="cdx-search-input cdx-search-input--has-end-button"> <div id="simpleSearch" class="cdx-search-input__input-wrapper" data-search-loc="header-moved"> <div class="cdx-text-input cdx-text-input--has-start-icon"> <input class="cdx-text-input__input" type="search" name="search" placeholder="Telusuri Wikipedia" aria-label="Telusuri Wikipedia" autocapitalize="sentences" title="Cari di Wikipedia [f]" accesskey="f" id="searchInput" > <span class="cdx-text-input__icon cdx-text-input__start-icon"></span> </div> <input type="hidden" name="title" value="Istimewa:Pencarian"> </div> <button class="cdx-button cdx-search-input__end-button">Cari</button> </form> </div> </div> </div> <nav class="vector-user-links vector-user-links-wide" aria-label="Perkakas pribadi"> <div class="vector-user-links-main"> <div id="p-vector-user-menu-preferences" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-userpage" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <nav class="vector-appearance-landmark" aria-label="Tampilan"> <div id="vector-appearance-dropdown" class="vector-dropdown " title="Change the appearance of the page's font size, width, and color" > <input type="checkbox" id="vector-appearance-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-appearance-dropdown" class="vector-dropdown-checkbox " aria-label="Tampilan" > <label id="vector-appearance-dropdown-label" for="vector-appearance-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-appearance mw-ui-icon-wikimedia-appearance"></span> <span class="vector-dropdown-label-text">Tampilan</span> </label> <div class="vector-dropdown-content"> <div id="vector-appearance-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_id.wikipedia.org&uselang=id" class=""><span>Menyumbang</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Istimewa:Buat_akun&returnto=Interleukin-1" title="Anda dianjurkan untuk membuat akun dan masuk log; meskipun, hal itu tidak diwajibkan" class=""><span>Buat akun baru</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Istimewa:Masuk_log&returnto=Interleukin-1" title="Anda disarankan untuk masuk log, meskipun hal itu tidak diwajibkan. [o]" accesskey="o" class=""><span>Masuk log</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="Opsi lainnya" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="Perkakas pribadi" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-ellipsis mw-ui-icon-wikimedia-ellipsis"></span> <span class="vector-dropdown-label-text">Perkakas pribadi</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="Menu pengguna" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_id.wikipedia.org&uselang=id"><span>Menyumbang</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Istimewa:Buat_akun&returnto=Interleukin-1" title="Anda dianjurkan untuk membuat akun dan masuk log; meskipun, hal itu tidak diwajibkan"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>Buat akun baru</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Istimewa:Masuk_log&returnto=Interleukin-1" title="Anda disarankan untuk masuk log, meskipun hal itu tidak diwajibkan. [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>Masuk log</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Halaman penyunting yang telah keluar log <a href="/wiki/Bantuan:Pengantar" aria-label="Pelajari lebih lanjut tentang menyunting"><span>pelajari lebih lanjut</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Istimewa:Kontribusi_saya" title="Daftar suntingan yang dibuat dari alamat IP ini [y]" accesskey="y"><span>Kontribusi</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Istimewa:Pembicaraan_saya" title="Pembicaraan tentang suntingan dari alamat IP ini [n]" accesskey="n"><span>Pembicaraan</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Situs"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Daftar isi" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Daftar isi</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">pindah ke bilah sisi</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">sembunyikan</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Awal</div> </a> </li> <li id="toc-IL-1β_dan_AR" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#IL-1β_dan_AR"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>IL-1β dan AR</span> </div> </a> <ul id="toc-IL-1β_dan_AR-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Referensi" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Referensi"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Referensi</span> </div> </a> <ul id="toc-Referensi-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Daftar isi" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Gulingkan daftar isi" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Gulingkan daftar isi</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Interleukin-1</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Pergi ke artikel dalam bahasa lain. Terdapat 20 bahasa" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-20" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">20 bahasa</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A5%D9%86%D8%AA%D8%B1%D9%84%D9%88%D9%83%D9%8A%D9%86_1" title="إنترلوكين 1 – Arab" lang="ar" hreflang="ar" data-title="إنترلوكين 1" data-language-autonym="العربية" data-language-local-name="Arab" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Interleucina-1" title="Interleucina-1 – Katalan" lang="ca" hreflang="ca" data-title="Interleucina-1" data-language-autonym="Català" data-language-local-name="Katalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Rodina_interleukinu-1" title="Rodina interleukinu-1 – Cheska" lang="cs" hreflang="cs" data-title="Rodina interleukinu-1" data-language-autonym="Čeština" data-language-local-name="Cheska" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Interleukin-1_family" title="Interleukin-1 family – Inggris" lang="en" hreflang="en" data-title="Interleukin-1 family" data-language-autonym="English" data-language-local-name="Inggris" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Interleucina-1" title="Interleucina-1 – Spanyol" lang="es" hreflang="es" data-title="Interleucina-1" data-language-autonym="Español" data-language-local-name="Spanyol" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Interleuzina_1" title="Interleuzina 1 – Basque" lang="eu" hreflang="eu" data-title="Interleuzina 1" data-language-autonym="Euskara" data-language-local-name="Basque" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%AE%D8%A7%D9%86%D9%88%D8%A7%D8%AF%D9%87_%D8%A7%DB%8C%D9%86%D8%AA%D8%B1%D9%84%D9%88%DA%A9%DB%8C%D9%86_%DB%B1" title="خانواده اینترلوکین ۱ – Persia" lang="fa" hreflang="fa" data-title="خانواده اینترلوکین ۱" data-language-autonym="فارسی" data-language-local-name="Persia" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Interleukine_1" title="Interleukine 1 – Prancis" lang="fr" hreflang="fr" data-title="Interleukine 1" data-language-autonym="Français" data-language-local-name="Prancis" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Interleucina_1" title="Interleucina 1 – Galisia" lang="gl" hreflang="gl" data-title="Interleucina 1" data-language-autonym="Galego" data-language-local-name="Galisia" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D4%BB%D5%B6%D5%BF%D5%A5%D6%80%D5%AC%D5%A5%D5%B5%D5%AF%D5%AB%D5%B6_1" title="Ինտերլեյկին 1 – Armenia" lang="hy" hreflang="hy" data-title="Ինտերլեյկին 1" data-language-autonym="Հայերեն" data-language-local-name="Armenia" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Interleuchina_1" title="Interleuchina 1 – Italia" lang="it" hreflang="it" data-title="Interleuchina 1" data-language-autonym="Italiano" data-language-local-name="Italia" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%A4%E3%83%B3%E3%82%BF%E3%83%BC%E3%83%AD%E3%82%A4%E3%82%AD%E3%83%B3-1" title="インターロイキン-1 – Jepang" lang="ja" hreflang="ja" data-title="インターロイキン-1" data-language-autonym="日本語" data-language-local-name="Jepang" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Interleukina_1" title="Interleukina 1 – Polski" lang="pl" hreflang="pl" data-title="Interleukina 1" data-language-autonym="Polski" data-language-local-name="Polski" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Interleucina_1" title="Interleucina 1 – Portugis" lang="pt" hreflang="pt" data-title="Interleucina 1" data-language-autonym="Português" data-language-local-name="Portugis" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D0%B9%D0%BA%D0%B8%D0%BD_1" title="Интерлейкин 1 – Rusia" lang="ru" hreflang="ru" data-title="Интерлейкин 1" data-language-autonym="Русский" data-language-local-name="Rusia" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Interleukin_1" title="Interleukin 1 – Serbo-Kroasia" lang="sh" hreflang="sh" data-title="Interleukin 1" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Kroasia" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Interlevkin-1" title="Interlevkin-1 – Sloven" lang="sl" hreflang="sl" data-title="Interlevkin-1" data-language-autonym="Slovenščina" data-language-local-name="Sloven" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D1%83%D0%BA%D0%B8%D0%BD_1" title="Интерлеукин 1 – Serbia" lang="sr" hreflang="sr" data-title="Интерлеукин 1" data-language-autonym="Српски / srpski" data-language-local-name="Serbia" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Interleukin_1" title="Interleukin 1 – Swedia" lang="sv" hreflang="sv" data-title="Interleukin 1" data-language-autonym="Svenska" data-language-local-name="Swedia" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E7%99%BD%E4%BB%8B%E7%B4%A0-1%E6%97%8F" title="白介素-1族 – Tionghoa" lang="zh" hreflang="zh" data-title="白介素-1族" data-language-autonym="中文" data-language-local-name="Tionghoa" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q1706141#sitelinks-wikipedia" title="Sunting pranala interwiki" class="wbc-editpage">Sunting pranala</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Ruang nama"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Interleukin-1" title="Lihat halaman isi [c]" accesskey="c"><span>Halaman</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Pembicaraan:Interleukin-1" rel="discussion" title="Pembicaraan halaman isi [t]" accesskey="t"><span>Pembicaraan</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Ubah varian bahasa" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Bahasa Indonesia</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Tampilan"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Interleukin-1"><span>Baca</span></a></li><li id="ca-ve-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Interleukin-1&veaction=edit" title="Sunting halaman ini [v]" accesskey="v"><span>Sunting</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Interleukin-1&action=edit" title="Sunting kode sumber halaman ini [e]" accesskey="e"><span>Sunting sumber</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Interleukin-1&action=history" title="Revisi sebelumnya dari halaman ini. [h]" accesskey="h"><span>Lihat riwayat</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Peralatan halaman"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Perkakas" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Perkakas</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Perkakas</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">pindah ke bilah sisi</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">sembunyikan</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Opsi lainnya" > <div class="vector-menu-heading"> Tindakan </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Interleukin-1"><span>Baca</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Interleukin-1&veaction=edit" title="Sunting halaman ini [v]" accesskey="v"><span>Sunting</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Interleukin-1&action=edit" title="Sunting kode sumber halaman ini [e]" accesskey="e"><span>Sunting sumber</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Interleukin-1&action=history"><span>Lihat riwayat</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> Umum </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Istimewa:Pranala_balik/Interleukin-1" title="Daftar semua halaman wiki yang memiliki pranala ke halaman ini [j]" accesskey="j"><span>Pranala balik</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Istimewa:Perubahan_terkait/Interleukin-1" rel="nofollow" title="Perubahan terbaru halaman-halaman yang memiliki pranala ke halaman ini [k]" accesskey="k"><span>Perubahan terkait</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Istimewa:Halaman_istimewa" title="Daftar semua halaman istimewa [q]" accesskey="q"><span>Halaman istimewa</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Interleukin-1&oldid=16235724" title="Pranala permanen untuk revisi halaman ini"><span>Pranala permanen</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Interleukin-1&action=info" title="Informasi lanjut tentang halaman ini"><span>Informasi halaman</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Istimewa:Kutip&page=Interleukin-1&id=16235724&wpFormIdentifier=titleform" title="Informasi tentang bagaimana mengutip halaman ini"><span>Kutip halaman ini</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Istimewa:UrlShortener&url=https%3A%2F%2Fid.wikipedia.org%2Fwiki%2FInterleukin-1"><span>Lihat URL pendek</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Istimewa:QrCode&url=https%3A%2F%2Fid.wikipedia.org%2Fwiki%2FInterleukin-1"><span>Unduh kode QR</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Cetak/ekspor </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-create_a_book" class="mw-list-item"><a href="/w/index.php?title=Istimewa:Buku&bookcmd=book_creator&referer=Interleukin-1"><span>Buat 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</div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Peralatan halaman"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Tampilan"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Tampilan</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">pindah ke bilah sisi</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">sembunyikan</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Dari Wikipedia bahasa Indonesia, ensiklopedia bebas</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="id" dir="ltr"><p><b>Interleukin-1</b> (IL-1) juga dikenal sebagai <i>leukocyte activating factor</i> (LAF), <i>B cell activating factor</i> (BAF), <i>mononuclear cell factor</i> (MCF), <i>leukocyte endogenous mediator</i> (LEM), hemopoeitin-1 dan sejumlah nama lain.<sup id="cite_ref-kresno_1-0" class="reference"><a href="#cite_note-kresno-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> IL-1 adalah sebutan bagi beberapa <a href="/wiki/Polipeptida" title="Polipeptida">polipeptida</a> <a href="/wiki/Sitokin" title="Sitokin">sitokin</a> <a href="/w/index.php?title=Interleukin-1_alfa&action=edit&redlink=1" class="new" title="Interleukin-1 alfa (halaman belum tersedia)">IL-1α</a>, <a href="/w/index.php?title=Interleukin-1_beta&action=edit&redlink=1" class="new" title="Interleukin-1 beta (halaman belum tersedia)">IL-1ß</a> dan <a href="/w/index.php?title=Antagonis_reseptor_interleukin-1&action=edit&redlink=1" class="new" title="Antagonis reseptor interleukin-1 (halaman belum tersedia)">IL-1Ra</a>, yang memainkan peran penting dalam regulasi <a href="/wiki/Sistem_kekebalan" class="mw-redirect" title="Sistem kekebalan">sistem kekebalan</a> dan respon <a href="/wiki/Peradangan" class="mw-redirect" title="Peradangan">peradangan</a>. </p><p>IL-1α dan IL-1ß masing-masing memiliki berkas <a href="/wiki/Gen" title="Gen">genetik</a> IL1A,<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> dan IL1B,<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> pada <a href="/wiki/Kromosom_2_(manusia)" title="Kromosom 2 (manusia)">kromosom 2</a> deret yang sama yaitu 2q14, dan merupakan sitokin <a href="/w/index.php?title=Pleiotropik&action=edit&redlink=1" class="new" title="Pleiotropik (halaman belum tersedia)">pleiotropik</a> hasil sekresi <a href="/wiki/Monosit" title="Monosit">monosit</a> dan <a href="/wiki/Makrofag" title="Makrofag">makrofag</a> berupa prohormon, sebagai respon saat sel mengalami cedera, oleh karena itu menginduksi <a href="/wiki/Apoptosis" title="Apoptosis">apoptosis</a>. Beberapa pakar menganggap bahwa defisiensi genetik IL1A berperan dalam <a href="/wiki/Artritis_reumatoid" class="mw-redirect" title="Artritis reumatoid">artritis reumatoid</a> (RA) dan <a href="/wiki/Alzheimer" class="mw-redirect" title="Alzheimer">Alzheimer</a>. </p><p>IL-1ß merupakan sitokin yang diiris oleh <a href="/w/index.php?title=Kaspase-1&action=edit&redlink=1" class="new" title="Kaspase-1 (halaman belum tersedia)">ICE</a>, dan berperan di dalam aktivitas seluler seperti <a href="/wiki/Proliferasi" title="Proliferasi">proliferasi</a>, <a href="/wiki/Diferensiasi" class="mw-redirect" title="Diferensiasi">diferensiasi</a> dan <a href="/wiki/Apoptosis" title="Apoptosis">apoptosis</a>. Induksi <a href="/w/index.php?title=Siklooksigenase-2&action=edit&redlink=1" class="new" title="Siklooksigenase-2 (halaman belum tersedia)">COX-2</a> pada sitokin ini di dalam <a href="/wiki/Sistem_saraf_pusat" title="Sistem saraf pusat">sistem saraf pusat</a> ditemukan sebagai penyebab <a href="/wiki/Hipersensitivitas" title="Hipersensitivitas">hipersensitivitas</a> yang memberikan rasa <a href="/wiki/Sakit" title="Sakit">sakit</a>. </p><p>Interleukin adalah faktor penyebab <a href="/wiki/Demam" title="Demam">demam</a>, mengontrol limfosit, meningkatkan sel sumsum tulang dan menyebabkan degenerasi pada persendian tulang. IL-1 segera menimbulkan demam pada saat mencapai <a href="/wiki/Hipotalamus" title="Hipotalamus">hipotalamus</a> dan meningkatkan temperatur tubuh dalam waktu 8-10 menit. Beberapa penelitian menunjukkan bahwa IL-1 menyebabkan demam pertama-tama dengan menginduksi pembentukan <a href="/wiki/Prostaglandin" title="Prostaglandin">prostaglandin</a>, terutama <a href="/w/index.php?title=Prostaglandin_E2&action=edit&redlink=1" class="new" title="Prostaglandin E2 (halaman belum tersedia)">prostaglandin E2</a>, kemudian zat ini selanjutnya bekerja dalam hipotalamus untuk membangkitkan reaksi demam.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Peningkatan suhu tubuh ini membantu sistem imun tubuh untuk melawan infeksi. IL-1 juga penting dalam pengaturan <a href="/w/index.php?title=Hematopoiesis&action=edit&redlink=1" class="new" title="Hematopoiesis (halaman belum tersedia)">hematopoiesis</a>.<sup id="cite_ref-wood_5-0" class="reference"><a href="#cite_note-wood-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>Interleukin-1 sendiri terdiri dari dua protein yang berbeda yaitu IL-1α dan IL-1β yang keduanya termasuk interleukin-1 superfamili.<sup id="cite_ref-wood_5-1" class="reference"><a href="#cite_note-wood-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Kebanyakan IL-1 yang ditemukan dalam sirkulasi adalah IL-1β.<sup id="cite_ref-abbas_6-0" class="reference"><a href="#cite_note-abbas-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="IL-1β_dan_AR"><span id="IL-1.CE.B2_dan_AR"></span>IL-1β dan AR</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin-1&veaction=edit&section=1" title="Sunting bagian: IL-1β dan AR" class="mw-editsection-visualeditor"><span>sunting</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukin-1&action=edit&section=1" title="Sunting kode sumber bagian: IL-1β dan AR"><span>sunting sumber</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>IL-1β merangsang sintesis dan sekresi aktivator plasminogen jaringan (tPA). <a href="/wiki/Plasminogen" title="Plasminogen">Plasminogen</a> merupakan substrat untuk enzim yang dapat disintesis oleh <a href="/w/index.php?title=Kondrosit&action=edit&redlink=1" class="new" title="Kondrosit (halaman belum tersedia)">kondrosit</a> dan mungkin masuk ke dalam sendi melalui difusi dari <a href="/w/index.php?title=Cairan_sinovium&action=edit&redlink=1" class="new" title="Cairan sinovium (halaman belum tersedia)">cairan sinovium</a>. Selain efek kataboliknya, pada konsentrasi yang lebih rendah daripada yang diperlukan untuk merangsang degradasi tulang rawan, IL-1β menekan sintesis <a href="/wiki/Proteoglikan" title="Proteoglikan">proteoglikan</a> oleh kondrosit, menghambat perbaikan matriks sehingga sangat destruktif bagi tulang rawan. IL-1β juga dapat meningkatkan pengaturan ekspresi <a href="/w/index.php?title=Molekul_adhesi&action=edit&redlink=1" class="new" title="Molekul adhesi (halaman belum tersedia)">molekul adhesi</a> pada <a href="/wiki/Endotel" class="mw-redirect" title="Endotel">endotel</a>, sehingga memungkinkan peningkatan migrasi limfosit dan neutrofil menuju area inflamasi secara berlebihan.<sup id="cite_ref-kresno_1-1" class="reference"><a href="#cite_note-kresno-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p><p><a href="/w/index.php?title=Fagosit_mononuklir&action=edit&redlink=1" class="new" title="Fagosit mononuklir (halaman belum tersedia)">Fagosit mononuklir</a> memproduksi <i>IL-1 receptor antagonist</i> (IL-1ra) yang homolog secara struktur dengan IL-1 dan berikatan pada reseptor yang sama tetapi tidak memiliki aktivitas biologis sehingga berperan sebagai inhibitor kompetitif terhadap IL-1. IL-1ra adalah regulator endogen dari aksi IL-1. IL-1ra dapat menghambat perkembangan <a href="/w/index.php?title=Erosi_tulang&action=edit&redlink=1" class="new" title="Erosi tulang (halaman belum tersedia)">erosi tulang</a> dan disetujui untuk terapi pasien AR serta memiliki kecenderungan untuk berhasil.<sup id="cite_ref-abbas_6-1" class="reference"><a href="#cite_note-abbas-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>Dalam mekanisme AR, IL-1β berperan sebagai faktor osteoklastogenik yang meningkatkan ekspresi <a href="/w/index.php?title=RANKL&action=edit&redlink=1" class="new" title="RANKL (halaman belum tersedia)">RANKL</a> (<i>receptor activator of nuclear factor kappa B ligand</i>) pada sel-sel stroma dan meningkatkan kemampuan survival dari <a href="/wiki/Osteoklas" title="Osteoklas">osteoklas</a>. Produksi RANKL mengaktifkan osteoklas yang berperan penting dalam <a href="/w/index.php?title=Resorpsi_tulang&action=edit&redlink=1" class="new" title="Resorpsi tulang (halaman belum tersedia)">resorpsi tulang</a> pada penyakit <a href="/wiki/Artritis" title="Artritis">artritis</a>. <a href="/w/index.php?title=RANKL&action=edit&redlink=1" class="new" title="RANKL (halaman belum tersedia)">RANKL</a> merupakan ligan yang berikatan dengan reseptornya, yaitu RANK (<i>receptor activator NF-κB</i>) yang merupakan salah satu famili TNF-R (<i>tumor necrosis factor receptor</i>). Reseptor tersebut diekspresikan pada osteoklas dan beberapa makrofag serta sel dendritik.<sup id="cite_ref-abbas_6-2" class="reference"><a href="#cite_note-abbas-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p><a href="/w/index.php?title=RANKL&action=edit&redlink=1" class="new" title="RANKL (halaman belum tersedia)">RANKL</a> akan mengikat <a href="/w/index.php?title=RANK&action=edit&redlink=1" class="new" title="RANK (halaman belum tersedia)">RANK</a> sedangkan MCSF (<i>macrophage colonys timulating factor</i>) akan mengikat c-fms pada permukaan monosit dan menginduksi diferensiasi monosit menjadi osteoklas. Osteoklas yang matang akan mendegradasi tulang dan tulang rawan (resorpsi tulang) sehingga terjadi degradasi tulang. IL-1β menginduksi proliferasi sel-sel sinovial dan meningkatkan produksi <a href="/w/index.php?title=Matriks_metalloproteinase&action=edit&redlink=1" class="new" title="Matriks metalloproteinase (halaman belum tersedia)">matriks metalloproteinase</a> (MMPs) oleh sel kondrosit dan sinovial, sehingga menyebabkan kerusakan <a href="/wiki/Kartilago" class="mw-redirect" title="Kartilago">kartilago</a> serta menghambat perbaikan kartilago melalui penghambatan sintesis matriks protein.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>Interaksi antara IL-1β dengan TNF-α juga dapat menyebabkan aktivitas osteoklastik melalui jalur yang berbeda dari jalur RANKL.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>Reseptor untuk IL-1β termasuk dalam superfamili reseptor imunoglobulin. Ikatan antara IL-1 dengan reseptor IL-1 tipe 1 (IL-1R) menyebabkan pembentukan protein adaptor yang disebut MyD88, dan aktivasi serin threonin kinase yang disebut IL-1 receptor asssociated kinase (IRAK). IRAK mengautofosforilasi dan berdisosiasi membentuk kompleks serta secara subsekuen mengikat TRAF-6 (TNF receptor-associated factor 6). Komplek IRAK-TRAF-6 mengaktifkan <a href="/wiki/NF-%CE%BAB" title="NF-κB">NF-κB</a> (nuclear factor κB) dan <a href="/wiki/AP-1" title="AP-1">AP-1</a> (activation protein-1). NF-κB yang aktif akan menstimulasi diferensiasi dan aktifasi dari osteoklas serta memicu munculnya inflamasi.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Referensi">Referensi</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin-1&veaction=edit&section=2" title="Sunting bagian: Referensi" class="mw-editsection-visualeditor"><span>sunting</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukin-1&action=edit&section=2" title="Sunting kode sumber bagian: Referensi"><span>sunting sumber</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r18833634">.mw-parser-output .reflist{font-size:90%;margin-bottom:0.5em;list-style-type:decimal}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-kresno-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-kresno_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-kresno_1-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text">Kresno SB, 1996, Imunologi: Diagnosis dan Prosedur Laboratorium, Jakarta: Fak. Kedokteran UI</span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><span style="font-size:0.95em; font-weight:bold; color:#777; cursor:help;" title="Bahasa Inggris" lang="Inggris">(Inggris)</span> <cite class="citation web"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/gene/3552">"IL1A interleukin 1, alpha [ Homo sapiens ]"</a>. <i>Entrez Gene</i><span class="reference-accessdate">. Diakses tanggal <span class="nowrap">2010-10-25</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Entrez+Gene&rft.atitle=IL1A+interleukin+1%2C+alpha+%5B+Homo+sapiens+%5D&rft_id=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgene%2F3552&rfr_id=info%3Asid%2Fid.wikipedia.org%3AInterleukin-1" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><span style="font-size:0.95em; font-weight:bold; color:#777; cursor:help;" title="Bahasa Inggris" lang="Inggris">(Inggris)</span> <cite class="citation web"><a rel="nofollow" class="external text" href="http://www.ncbi.nlm.nih.gov/gene/3553">"IL1B interleukin 1, beta [ Homo sapiens ]"</a>. <i>Entrez Gene</i><span class="reference-accessdate">. Diakses tanggal <span class="nowrap">2010-10-25</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Entrez+Gene&rft.atitle=IL1B+interleukin+1%2C+beta+%5B+Homo+sapiens+%5D&rft_id=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgene%2F3553&rfr_id=info%3Asid%2Fid.wikipedia.org%3AInterleukin-1" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text">Guyton AC, Hall JE, 2000, Buku Ajar Fisiologi Kedokteran, Edisi 9, Jakarta: Penerbit Buku Kedokteran EGC</span> </li> <li id="cite_note-wood-5"><span class="mw-cite-backlink">^ <a href="#cite_ref-wood_5-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-wood_5-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text">Woodley MD, Wheelan L, 1995, Pedoman Pengobatan, Yogyakarta: Penerbit Yayasan Essentia Medika & Penerbit Andi Offset</span> </li> <li id="cite_note-abbas-6"><span class="mw-cite-backlink">^ <a href="#cite_ref-abbas_6-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-abbas_6-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-abbas_6-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text">Abbas AK, Lichtman AH, 2005, Cellular and Molecular Immunology, 5th Edition. Philadelphia: Elsevier Saunders:253-254</span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-7">^</a></b></span> <span class="reference-text"><cite class="citation journal">Davidson A, Diamond B (2001). 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Fakultas Farmasi UGM</span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-9">^</a></b></span> <span class="reference-text"><cite class="citation journal">Suda T, Takahashi N, Udagawa N, Miyaura C (2001). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3273194">"The molecular mechanism of osteoclastogenesis: ODF/RANKL-dependent and independent pathways"</a>. <i>Arthritis Res</i>. <b>3</b> (Supll A): L024. <a href="/wiki/Digital_object_identifier" class="mw-redirect" title="Digital object identifier">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1186%2Far168">10.1186/ar168</a>. <a href="/wiki/PubMed_Central" title="PubMed Central">PMC</a> <span class="plainlinks"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3273194">3273194</a> <span typeof="mw:File"><span title="Dapat diakses gratis"><img alt="alt=Dapat diakses gratis" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png" decoding="async" width="9" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/14px-Lock-green.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/18px-Lock-green.svg.png 2x" data-file-width="512" data-file-height="813" /></span></span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Arthritis+Res.&rft.atitle=The+molecular+mechanism+of+osteoclastogenesis%3A+ODF%2FRANKL-dependent+and+independent+pathways&rft.volume=3&rft.issue=Supll+A&rft.pages=L024&rft.date=2001&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3273194&rft_id=info%3Adoi%2F10.1186%2Far168&rft.aulast=Suda&rft.aufirst=T&rft.au=Takahashi%2C+N&rft.au=Udagawa%2C+N&rft.au=Miyaura%2C+C&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3273194&rfr_id=info%3Asid%2Fid.wikipedia.org%3AInterleukin-1" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-10">^</a></b></span> <span class="reference-text"><cite class="citation journal">Udagawa N, Kotake S, Katamani N, Takahashi N, Suda T (2002). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC128939">"The molecular mechanism of osteoclastogenesis in rheumatoid arthritis"</a>. <i>Arthritis Res</i>. <b>4</b> (5): 281–9. <a href="/wiki/PubMed_Central" title="PubMed Central">PMC</a> <span class="plainlinks"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC128939">128939</a> <span typeof="mw:File"><span title="Dapat diakses gratis"><img alt="alt=Dapat diakses gratis" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png" decoding="async" width="9" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/14px-Lock-green.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/18px-Lock-green.svg.png 2x" data-file-width="512" data-file-height="813" /></span></span></span>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/12223101">12223101</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Arthritis+Res.&rft.atitle=The+molecular+mechanism+of+osteoclastogenesis+in+rheumatoid+arthritis&rft.volume=4&rft.issue=5&rft.pages=281-9&rft.date=2002&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC128939&rft_id=info%3Apmid%2F12223101&rft.aulast=Udagawa&rft.aufirst=N&rft.au=Kotake%2C+S&rft.au=Katamani%2C+N&rft.au=Takahashi%2C+N&rft.au=Suda%2C+T&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC128939&rfr_id=info%3Asid%2Fid.wikipedia.org%3AInterleukin-1" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-11">^</a></b></span> <span class="reference-text"><cite class="citation journal">Tak PP, Firestein GS (2001). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC198552">"NF-kappaB: a key role in inflammatory diseases"</a>. <i>J Clin Invest</i>. <b>107</b> (1): 7–11. <a href="/wiki/PubMed_Central" title="PubMed Central">PMC</a> <span class="plainlinks"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC198552">198552</a> <span typeof="mw:File"><span title="Dapat diakses gratis"><img alt="alt=Dapat diakses gratis" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png" decoding="async" width="9" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/14px-Lock-green.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/18px-Lock-green.svg.png 2x" data-file-width="512" data-file-height="813" /></span></span></span>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/11134171">11134171</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J+Clin+Invest.&rft.atitle=NF-kappaB%3A+a+key+role+in+inflammatory+diseases&rft.volume=107&rft.issue=1&rft.pages=7-11&rft.date=2001&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC198552&rft_id=info%3Apmid%2F11134171&rft.aulast=Tak&rft.aufirst=PP&rft.au=Firestein%2C+GS&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC198552&rfr_id=info%3Asid%2Fid.wikipedia.org%3AInterleukin-1" class="Z3988"><span style="display:none;"> </span></span></span> </li> </ol></div></div> <p><br /> </p> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r23782733">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output 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title="Kalsitriol">Kalsitriol</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/w/index.php?title=Hormon_peptida&action=edit&redlink=1" class="new" title="Hormon peptida (halaman belum tersedia)">Peptida</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Faktor_transkripsi" scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Faktor_transkripsi" title="Faktor transkripsi">Faktor transkripsi</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/AP-1" title="AP-1">AP-1</a>  <b>·</b> <span style="white-space:nowrap;"> <a href="/wiki/C/EBP-alfa" title="C/EBP-alfa">C/EBP-α</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/C/EBP-beta" title="C/EBP-beta">β</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/NF-%CE%BAB" title="NF-κB">NF-κB</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Protein_FLICE-i" title="Protein FLICE-i">FLIP</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Protein_STAT" title="Protein STAT">STAT</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/STAT-1" title="STAT-1">1</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/STAT-2" title="STAT-2">2</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/STAT-3" title="STAT-3">3</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/STAT-4" title="STAT-4">4</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/STAT-5" title="STAT-5">5</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/STAT-6" title="STAT-6">6</a></span></div></td></tr></tbody></table><div> <a href="/wiki/Insulin" title="Insulin">Insulin</a>  <b>·</b> <span style="white-space:nowrap;"> <a href="/wiki/Peptida_CGR" title="Peptida CGR">CGRP</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Kortikoliberin" class="mw-redirect" title="Kortikoliberin">CRH</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Protein_SREB" title="Protein SREB">SREBP</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Androgen" title="Androgen">Androgen</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Estrogen" title="Estrogen">Estrogen</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Pregnenolon" title="Pregnenolon">Pregnenolon</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Progestagen" class="mw-redirect" title="Progestagen">Progestagen</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Progesteron" title="Progesteron">P4</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Testosteron" title="Testosteron">Testosteron</a></span></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/w/index.php?title=Ekstraselular&action=edit&redlink=1" class="new" title="Ekstraselular (halaman belum tersedia)">Ekstraselular</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/w/index.php?title=Hormon_glikoprotein&action=edit&redlink=1" class="new" title="Hormon glikoprotein (halaman belum tersedia)">Glikoprotein</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Hormon_hCG" class="mw-redirect" title="Hormon hCG">hCG</a>  <b>·</b> <span style="white-space:nowrap;"> <a href="/wiki/Hormon_perangsang_folikel" title="Hormon perangsang folikel">FSH</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Protein_GPIHB-1" title="Protein GPIHB-1">GPIHBP-1</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Hormon_pelutein" title="Hormon pelutein">LH</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Tirotropin" class="mw-redirect" title="Tirotropin">TSH</a></span></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Katekolamin" class="mw-redirect" title="Katekolamin">Katekolamin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Adrenalin" title="Adrenalin">Adrenalin</a>  <b>·</b> <span style="white-space:nowrap;"> <a href="/wiki/Dopamin" title="Dopamin">PIH</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Noradrenalin" title="Noradrenalin">Noradrenalin</a></span></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/w/index.php?title=Hormon_peptida&action=edit&redlink=1" class="new" title="Hormon peptida (halaman belum tersedia)">Peptida</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Kortikotropin" class="mw-redirect" title="Kortikotropin">ACTH</a>  <b>·</b> <span style="white-space:nowrap;"> <a href="/wiki/Adrenomedulin" title="Adrenomedulin">AM</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Angiotensin" title="Angiotensin">Angiotensin</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Kalsitonin" title="Kalsitonin">CT</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Gastrin" title="Gastrin">Gastrin</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Glukagon" title="Glukagon">Glukagon</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Luliberin" class="mw-redirect" title="Luliberin">GnRH</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Somatotropin" title="Somatotropin">GH</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Somatostatin" title="Somatostatin">GHIH</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Somatokrinin" title="Somatokrinin">GHRH</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Ghrelin" class="mw-redirect" title="Ghrelin">GHS</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Amilin" title="Amilin">IAPP</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Oksitosin" title="Oksitosin">OT</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Laktogen" title="Laktogen">PRL</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Tiroliberin" class="mw-redirect" title="Tiroliberin">TRH</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Vasopresin" title="Vasopresin">VP</a></span></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Sitokin" title="Sitokin">Sitokin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Kemokina" scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Kemokina" title="Kemokina">Kemokina</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/w/index.php?title=C5a&action=edit&redlink=1" class="new" title="C5a (halaman belum tersedia)">C5a</a>  <b>·</b> <span style="white-space:nowrap;"> <a href="/wiki/CCL2" title="CCL2">CCL2</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/CCL5" title="CCL5">CCL5</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Faktor_stimulasi_koloni_makrofaga_granulosit" title="Faktor stimulasi koloni makrofaga granulosit">GSM-CSF</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/LPS" class="mw-disambig" title="LPS">LPS</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/w/index.php?title=MCP-1&action=edit&redlink=1" class="new" title="MCP-1 (halaman belum tersedia)">MCP-1</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a class="mw-selflink selflink">IL-1</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Interleukin-2" title="Interleukin-2">IL-2</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Interleukin-3" title="Interleukin-3">IL-3</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Interleukin-4" title="Interleukin-4">IL-4</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Interleukin-5" title="Interleukin-5">IL-5</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Interleukin-6" title="Interleukin-6">IL-6</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Interleukin-8" title="Interleukin-8">IL-8</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Interleukin-10" title="Interleukin-10">IL-10</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Interleukin-12" class="mw-redirect" title="Interleukin-12">IL-12</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Interleukin-13" title="Interleukin-13">IL-13</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Interleukin-15" title="Interleukin-15">IL-15</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Interleukin-18" title="Interleukin-18">IL-18</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/CXCL10" title="CXCL10">IP-10</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Resistin" title="Resistin">RETN</a></span></div></td></tr></tbody></table><div> <a href="/wiki/Eritropoietin" title="Eritropoietin">EPO</a>  <b>·</b> <span style="white-space:nowrap;"> <a href="/wiki/Interleukin" title="Interleukin">Interleukin</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Faktor_stimulasi_koloni_granulosit" title="Faktor stimulasi koloni granulosit">G-CSF</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/w/index.php?title=Onkostatin_M&action=edit&redlink=1" class="new" title="Onkostatin M (halaman belum tersedia)">OM</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/LIF" class="mw-disambig" title="LIF">LIF</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Interferon" title="Interferon">IFN</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/CD" class="mw-redirect" title="CD">CD</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Faktor_nekrosis_tumor-alfa" title="Faktor nekrosis tumor-alfa">TNF-α</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/w/index.php?title=Faktor_nekrosis_tumor-beta&action=edit&redlink=1" class="new" title="Faktor nekrosis tumor-beta (halaman belum tersedia)">LT</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/w/index.php?title=Ligand&action=edit&redlink=1" class="new" title="Ligand (halaman belum tersedia)">Ligand</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/w/index.php?title=TGF&action=edit&redlink=1" class="new" title="TGF (halaman belum tersedia)">TGF</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/w/index.php?title=MIF&action=edit&redlink=1" class="new" title="MIF (halaman belum tersedia)">MIF</a></span></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/w/index.php?title=Tropik&action=edit&redlink=1" class="new" title="Tropik (halaman belum tersedia)">Tropik</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Faktor neurotropik</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Neurotrofin" title="Neurotrofin">Neurotrofin</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Prosaposin" title="Prosaposin">PSAP</a>  <b>·</b> <span style="white-space:nowrap;"> <a href="/wiki/Saposin" title="Saposin">SAP</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Faktor_pertumbuhan_saraf" title="Faktor pertumbuhan saraf">NGF</a></span></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/w/index.php?title=GFL&action=edit&redlink=1" class="new" title="GFL (halaman belum tersedia)">GFL</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <span style="white-space:nowrap"></span></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/w/index.php?title=Sitokin_neuropoietik&action=edit&redlink=1" class="new" title="Sitokin neuropoietik (halaman belum tersedia)">Sitokin neuropoietik</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <span style="white-space:nowrap"></span></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Neurotransmiter" title="Neurotransmiter">Neurotransmiter</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Serotonin" title="Serotonin">5-HT</a></div></td></tr></tbody></table><div> <a href="/wiki/Melatonin" title="Melatonin">Melatonin</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Faktor pertumbuhan</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/w/index.php?title=Hormon_EGF&action=edit&redlink=1" class="new" title="Hormon EGF (halaman belum tersedia)">EGF</a>  <b>·</b> <span style="white-space:nowrap;"> <a href="/wiki/Faktor_pertumbuhan_hepatosit" title="Faktor pertumbuhan hepatosit">HGF</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Protein_MA" title="Protein MA">MAP</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/w/index.php?title=Hormon_PDGF&action=edit&redlink=1" class="new" title="Hormon PDGF (halaman belum tersedia)">PDGF</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/w/index.php?title=Hormon_TGF&action=edit&redlink=1" class="new" title="Hormon TGF (halaman belum tersedia)">TGF</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Trombopoietin" title="Trombopoietin">TPO</a></span></div></td></tr></tbody></table><div> <a href="/wiki/Kortikotropin" class="mw-redirect" title="Kortikotropin">ACTH</a>  <b>·</b> <span style="white-space:nowrap;"> <a href="/wiki/Hormon_perangsang_folikel" title="Hormon perangsang folikel">FSH</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Hormon_pelutein" title="Hormon pelutein">LH</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Tirotropin" class="mw-redirect" title="Tirotropin">TSH</a></span></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Inkretin" title="Inkretin">Inkretin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/GLP-1" title="GLP-1">GLP-1</a>  <b>·</b> <span style="white-space:nowrap;"> <a href="/wiki/GIP" title="GIP">GIP</a></span></div></td></tr></tbody></table><div> <a href="/wiki/Endotelin" title="Endotelin">ET</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Metabolit" title="Metabolit">Metabolit</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <span style="white-space:nowrap"></span></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/w/index.php?title=Prenoid&action=edit&redlink=1" class="new" title="Prenoid (halaman belum tersedia)">Prenoid</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <span style="white-space:nowrap"></span></div></td></tr></tbody></table><div> <a href="/w/index.php?title=Hormon_Adrenokortikotopik&action=edit&redlink=1" class="new" title="Hormon Adrenokortikotopik (halaman belum tersedia)">Adrenokortikotopik</a>  <b>·</b> <span style="white-space:nowrap;"> <a href="/wiki/Eritropoietin" title="Eritropoietin">Eritropoietin</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Feromon" title="Feromon">Feromon</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Leptin" title="Leptin">Leptin</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/w/index.php?title=Isotosin&action=edit&redlink=1" class="new" title="Isotosin (halaman belum tersedia)">Isotosin</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Gastrin" title="Gastrin">Gastrin</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Laktogen" title="Laktogen">Laktogen</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/w/index.php?title=Mesotosin&action=edit&redlink=1" class="new" title="Mesotosin (halaman belum tersedia)">Mesotosin</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/w/index.php?title=Vasotosin&action=edit&redlink=1" class="new" title="Vasotosin (halaman belum tersedia)">Vasotosin</a></span></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Tokoh</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0;width:auto; padding:0; line-height:1.4em;"><div style="padding:0 0.25em"><a href="/wiki/E.C._Kendall" title="E.C. Kendall">E.C. Kendall</a>  <b>·</b> <span style="white-space:nowrap;"> <a href="/wiki/Edmond_H._Fischer" title="Edmond H. Fischer">Edmond H. Fischer</a></span></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div>Lihat pula : <a href="/wiki/Templat:Asam_amino" title="Templat:Asam amino">Asam amino</a>  <b>·</b> <span style="white-space:nowrap;"> <a href="/wiki/Templat:Darah" title="Templat:Darah">Darah</a>  <b>·</b></span> <span style="white-space:nowrap;"> <a href="/wiki/Templat:Enzim" title="Templat:Enzim">Enzim</a></span></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Diperoleh dari "<a dir="ltr" href="https://id.wikipedia.org/w/index.php?title=Interleukin-1&oldid=16235724">https://id.wikipedia.org/w/index.php?title=Interleukin-1&oldid=16235724</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Istimewa:Daftar_kategori" title="Istimewa:Daftar kategori">Kategori</a>: <ul><li><a href="/wiki/Kategori:Hormon" title="Kategori:Hormon">Hormon</a></li><li><a href="/wiki/Kategori:Sitokin" title="Kategori:Sitokin">Sitokin</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> Halaman ini terakhir diubah pada 29 November 2019, pukul 12.00.</li> <li id="footer-info-copyright">Teks tersedia di bawah <a rel="nofollow" class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.en">Lisensi Atribusi-BerbagiSerupa Creative Commons</a>; ketentuan tambahan mungkin berlaku. 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