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class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="52887487" href="https://www.academia.edu/Documents/in/History_of_Biblical_Interpretation"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/LorisChahl","location":"/LorisChahl","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/LorisChahl","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["History of Biblical Interpretation"]}" data-trace="false" data-dom-id="Pill-react-component-66ba3a55-6c5e-4c39-985c-4a71bb56338a"></div> <div id="Pill-react-component-66ba3a55-6c5e-4c39-985c-4a71bb56338a"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="52887487" href="https://www.academia.edu/Documents/in/History_Of_The_Bible_Biblical_Canon"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["History Of The Bible/Biblical Canon"]}" data-trace="false" data-dom-id="Pill-react-component-bdf4fb0e-ddfc-439f-9ffc-960dd1573e18"></div> <div id="Pill-react-component-bdf4fb0e-ddfc-439f-9ffc-960dd1573e18"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="52887487" href="https://www.academia.edu/Documents/in/Synoptic_Gospels"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Synoptic 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data-trace="false" data-dom-id="Pill-react-component-1d8631ff-072a-404a-9364-c2e0b59ccfdb"></div> <div id="Pill-react-component-1d8631ff-072a-404a-9364-c2e0b59ccfdb"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Loris Chahl</h3></div><div class="js-work-strip profile--work_container" data-work-id="28250640"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250640/Effect_of_the_nonpeptide_NK_1_receptor_antagonist_CP_96_345_on_the_morphine_withdrawal_response_of_guinea_pigs"><img alt="Research paper thumbnail of Effect of the nonpeptide NK-1 receptor antagonist CP-96,345 on the morphine withdrawal response of guinea-pigs" class="work-thumbnail" src="https://attachments.academia-assets.com/48571687/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250640/Effect_of_the_nonpeptide_NK_1_receptor_antagonist_CP_96_345_on_the_morphine_withdrawal_response_of_guinea_pigs">Effect of the nonpeptide NK-1 receptor antagonist CP-96,345 on the morphine withdrawal response of guinea-pigs</a></div><div class="wp-workCard_item"><span>Regul Peptides</span><span>, 1992</span></div><div class="wp-workCard_item 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href="https://www.academia.edu/28250639/Effect_of_CP_96_345_on_the_6Met59enkephalin_washout_withdrawal_response_of_the_guinea_pig_isolated_ileum"><img alt="Research paper thumbnail of Effect of CP-96,345 on the 6Met59enkephalin washout withdrawal response of the guinea-pig isolated ileum" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250639/Effect_of_CP_96_345_on_the_6Met59enkephalin_washout_withdrawal_response_of_the_guinea_pig_isolated_ileum">Effect of CP-96,345 on the 6Met59enkephalin washout withdrawal response of the guinea-pig isolated ileum</a></div><div class="wp-workCard_item"><span>Regul Peptides</span><span>, 1992</span></div><div class="wp-workCard_item wp-workCard--actions"><span 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href="https://www.academia.edu/28250638/Effect_of_Opioids_and_Opioid_Withdrawal_on_Spontaneous_Release_of_Substance_P_from_Guinea_Pig_Brain_and_Spinal_Cord_In_Vitro">Effect of Opioids and Opioid Withdrawal on Spontaneous Release of Substance P from Guinea-Pig Brain and Spinal Cord In Vitro</a></div><div class="wp-workCard_item"><span>Pharmacology Reviews and Communications</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250638"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span 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href="https://www.academia.edu/28250637/Tachykinins_and_neuropsychiatric_disorders">Tachykinins and neuropsychiatric disorders</a></div><div class="wp-workCard_item"><span>Current drug targets</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The classical tachykinins, substance P, neurokinin A and neurokinin B are predominantly found in ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The classical tachykinins, substance P, neurokinin A and neurokinin B are predominantly found in the nervous system where they act as neurotransmitters and neuromodulators. Their respective preferred receptors are NK1, NK2, and NK3 receptors. The presence of substance P in nociceptive primary afferent neurons, electrophysiological studies showing that it activated neurons in the dorsal horn of the spinal cord, and behavioral studies in animals, supported the concept that substance P was an important transmitter in the nociceptive pathway. It was therefore surprising that non-peptide NK1 receptor antagonists were ineffective as analgesics in clinical pain conditions. Nevertheless, the discovery that NK1 receptor antagonists had antidepressant activity led to renewed interest in these antagonists. It is disappointing that clinical trials of MK869 (aprepitant) for depression were suspended. The future of NK1 receptor antagonists as antidepressant drugs will depend on the outcome of cli...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250637"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250637"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250637; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250637]").text(description); $(".js-view-count[data-work-id=28250637]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250637; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250637']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250637, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250637]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250637,"title":"Tachykinins and neuropsychiatric disorders","translated_title":"","metadata":{"abstract":"The classical tachykinins, substance P, neurokinin A and neurokinin B are predominantly found in the nervous system where they act as neurotransmitters and neuromodulators. Their respective preferred receptors are NK1, NK2, and NK3 receptors. The presence of substance P in nociceptive primary afferent neurons, electrophysiological studies showing that it activated neurons in the dorsal horn of the spinal cord, and behavioral studies in animals, supported the concept that substance P was an important transmitter in the nociceptive pathway. It was therefore surprising that non-peptide NK1 receptor antagonists were ineffective as analgesics in clinical pain conditions. Nevertheless, the discovery that NK1 receptor antagonists had antidepressant activity led to renewed interest in these antagonists. It is disappointing that clinical trials of MK869 (aprepitant) for depression were suspended. The future of NK1 receptor antagonists as antidepressant drugs will depend on the outcome of cli...","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Current drug targets"},"translated_abstract":"The classical tachykinins, substance P, neurokinin A and neurokinin B are predominantly found in the nervous system where they act as neurotransmitters and neuromodulators. Their respective preferred receptors are NK1, NK2, and NK3 receptors. The presence of substance P in nociceptive primary afferent neurons, electrophysiological studies showing that it activated neurons in the dorsal horn of the spinal cord, and behavioral studies in animals, supported the concept that substance P was an important transmitter in the nociceptive pathway. It was therefore surprising that non-peptide NK1 receptor antagonists were ineffective as analgesics in clinical pain conditions. Nevertheless, the discovery that NK1 receptor antagonists had antidepressant activity led to renewed interest in these antagonists. It is disappointing that clinical trials of MK869 (aprepitant) for depression were suspended. The future of NK1 receptor antagonists as antidepressant drugs will depend on the outcome of cli...","internal_url":"https://www.academia.edu/28250637/Tachykinins_and_neuropsychiatric_disorders","translated_internal_url":"","created_at":"2016-09-04T16:37:44.846-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Tachykinins_and_neuropsychiatric_disorders","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":171144,"name":"Mental Disorders","url":"https://www.academia.edu/Documents/in/Mental_Disorders"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250636"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250636/Tachykinins_and_Neuropsychiatric_Disorders"><img alt="Research paper thumbnail of Tachykinins and Neuropsychiatric Disorders" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250636/Tachykinins_and_Neuropsychiatric_Disorders">Tachykinins and Neuropsychiatric Disorders</a></div><div class="wp-workCard_item"><span>Current Drug Targets</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The classical tachykinins, substance P, neurokinin A and neurokinin B are predominantly found in ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The classical tachykinins, substance P, neurokinin A and neurokinin B are predominantly found in the nervous system where they act as neurotransmitters and neuromodulators. Their respective preferred receptors are NK1, NK2, and NK3 receptors. The presence of substance P in nociceptive primary afferent neurons, electrophysiological studies showing that it activated neurons in the dorsal horn of the spinal cord, and behavioral studies in animals, supported the concept that substance P was an important transmitter in the nociceptive pathway. It was therefore surprising that non-peptide NK1 receptor antagonists were ineffective as analgesics in clinical pain conditions. Nevertheless, the discovery that NK1 receptor antagonists had antidepressant activity led to renewed interest in these antagonists. It is disappointing that clinical trials of MK869 (aprepitant) for depression were suspended. The future of NK1 receptor antagonists as antidepressant drugs will depend on the outcome of clinical trials with other NK1 receptor antagonists. NK1 receptor antagonists were also found to be effective antiemetics, and aprepitant has recently become available for the treatment of chemotherapy induced emesis. Although less is known of the potential of NK2 and NK3 receptor antagonists, recent trials of NK3 receptor antagonists have shown efficacy in schizophrenia. The discovery of a new family of tachykinins, the hemokinins and endokinins, which acts on NK1 receptors and has potent effects on immune cells, has implications for the clinical use of NK1 receptor antagonists. Thus specific therapeutic strategies may be required to enable NK1 receptor antagonists to be introduced for treatment of neuropsychiatric disorders.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250636"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250636"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250636; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250636]").text(description); $(".js-view-count[data-work-id=28250636]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250636; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250636']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250636, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250636]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250636,"title":"Tachykinins and Neuropsychiatric Disorders","translated_title":"","metadata":{"abstract":"The classical tachykinins, substance P, neurokinin A and neurokinin B are predominantly found in the nervous system where they act as neurotransmitters and neuromodulators. Their respective preferred receptors are NK1, NK2, and NK3 receptors. The presence of substance P in nociceptive primary afferent neurons, electrophysiological studies showing that it activated neurons in the dorsal horn of the spinal cord, and behavioral studies in animals, supported the concept that substance P was an important transmitter in the nociceptive pathway. It was therefore surprising that non-peptide NK1 receptor antagonists were ineffective as analgesics in clinical pain conditions. Nevertheless, the discovery that NK1 receptor antagonists had antidepressant activity led to renewed interest in these antagonists. It is disappointing that clinical trials of MK869 (aprepitant) for depression were suspended. The future of NK1 receptor antagonists as antidepressant drugs will depend on the outcome of clinical trials with other NK1 receptor antagonists. NK1 receptor antagonists were also found to be effective antiemetics, and aprepitant has recently become available for the treatment of chemotherapy induced emesis. Although less is known of the potential of NK2 and NK3 receptor antagonists, recent trials of NK3 receptor antagonists have shown efficacy in schizophrenia. The discovery of a new family of tachykinins, the hemokinins and endokinins, which acts on NK1 receptors and has potent effects on immune cells, has implications for the clinical use of NK1 receptor antagonists. Thus specific therapeutic strategies may be required to enable NK1 receptor antagonists to be introduced for treatment of neuropsychiatric disorders.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Current Drug Targets"},"translated_abstract":"The classical tachykinins, substance P, neurokinin A and neurokinin B are predominantly found in the nervous system where they act as neurotransmitters and neuromodulators. Their respective preferred receptors are NK1, NK2, and NK3 receptors. The presence of substance P in nociceptive primary afferent neurons, electrophysiological studies showing that it activated neurons in the dorsal horn of the spinal cord, and behavioral studies in animals, supported the concept that substance P was an important transmitter in the nociceptive pathway. It was therefore surprising that non-peptide NK1 receptor antagonists were ineffective as analgesics in clinical pain conditions. Nevertheless, the discovery that NK1 receptor antagonists had antidepressant activity led to renewed interest in these antagonists. It is disappointing that clinical trials of MK869 (aprepitant) for depression were suspended. The future of NK1 receptor antagonists as antidepressant drugs will depend on the outcome of clinical trials with other NK1 receptor antagonists. NK1 receptor antagonists were also found to be effective antiemetics, and aprepitant has recently become available for the treatment of chemotherapy induced emesis. Although less is known of the potential of NK2 and NK3 receptor antagonists, recent trials of NK3 receptor antagonists have shown efficacy in schizophrenia. The discovery of a new family of tachykinins, the hemokinins and endokinins, which acts on NK1 receptors and has potent effects on immune cells, has implications for the clinical use of NK1 receptor antagonists. Thus specific therapeutic strategies may be required to enable NK1 receptor antagonists to be introduced for treatment of neuropsychiatric disorders.","internal_url":"https://www.academia.edu/28250636/Tachykinins_and_Neuropsychiatric_Disorders","translated_internal_url":"","created_at":"2016-09-04T16:37:44.726-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Tachykinins_and_Neuropsychiatric_Disorders","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":171144,"name":"Mental Disorders","url":"https://www.academia.edu/Documents/in/Mental_Disorders"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250634"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250634/TRPs_Links_to_schizophrenia"><img alt="Research paper thumbnail of TRP's: Links to schizophrenia?" class="work-thumbnail" src="https://attachments.academia-assets.com/48571682/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250634/TRPs_Links_to_schizophrenia">TRP's: Links to schizophrenia?</a></div><div class="wp-workCard_item"><span>Biochimica Et Biophysica Acta Molecular Basis of Disease</span><span>, Aug 31, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3257cdeec0a2600ace5e591ea6f6fed0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":48571682,"asset_id":28250634,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/48571682/download_file?st=MTczMjc1Nzk0Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250634"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250634"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250634; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250634]").text(description); $(".js-view-count[data-work-id=28250634]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250634; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250634']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250634, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3257cdeec0a2600ace5e591ea6f6fed0" } } $('.js-work-strip[data-work-id=28250634]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250634,"title":"TRP's: Links to schizophrenia?","translated_title":"","metadata":{"grobid_abstract":"Schizophrenia is a chronic psychiatric disorder the cause of which is unknown. It is considered to be a neurodevelopmental disorder that results from an interaction of genetic and environmental factors. Direct evidence for links between schizophrenia and TRP channels is lacking. However, several aspects of the pathophysiology of the disorder point to a possible involvement of TRP channels. In this review evidence for links between TRP channels and schizophrenia with respect to neurodevelopment, dopaminergic and cannabinoid systems, thermoregulation, and sensory processes, is discussed. Investigation of these links holds the prospect of a new understanding of schizophrenia with resultant therapeutic advances.","publication_date":{"day":31,"month":8,"year":2007,"errors":{}},"publication_name":"Biochimica Et Biophysica Acta Molecular Basis of Disease","grobid_abstract_attachment_id":48571682},"translated_abstract":null,"internal_url":"https://www.academia.edu/28250634/TRPs_Links_to_schizophrenia","translated_internal_url":"","created_at":"2016-09-04T16:37:00.655-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":48571682,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/48571682/thumbnails/1.jpg","file_name":"TRPs_Links_to_schizophrenia20160904-21441-1eri0qp.pdf","download_url":"https://www.academia.edu/attachments/48571682/download_file?st=MTczMjc1Nzk0Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"TRPs_Links_to_schizophrenia.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/48571682/TRPs_Links_to_schizophrenia20160904-21441-1eri0qp-libre.pdf?1473032421=\u0026response-content-disposition=attachment%3B+filename%3DTRPs_Links_to_schizophrenia.pdf\u0026Expires=1732739735\u0026Signature=XOUUuKvtRNMr9Es2FypmUS5P7tAQ-6u837VBptzXXHDrZDnYOQ7jaQ0qYfPThyEkI7BJoGkoEW47k8SmueRvvGiqHHJMEkOxJmDnaob3SJx35FWR-tjyAbJLSmxYgKGvKmkiVoiVUISOzSD407EViBtcnJ7u-bM5WMmA2yXe4pTLX69LAxkR9JYzB4sLp9ueWsLRgxeIIama57vXRY6gLcpCulCsarwTcbnFYKBT7M4OHEt5bF~ZoX5l-RVk2IP6RJA53guKIRr7p8tI90onYmby-Qlw124aaTp3j3rZu4J-z7L77~bq1g0EYEgwtZa8sQjXD6o6stwKr~QXQiUlGw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"TRPs_Links_to_schizophrenia","translated_slug":"","page_count":38,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[{"id":48571682,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/48571682/thumbnails/1.jpg","file_name":"TRPs_Links_to_schizophrenia20160904-21441-1eri0qp.pdf","download_url":"https://www.academia.edu/attachments/48571682/download_file?st=MTczMjc1Nzk0Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"TRPs_Links_to_schizophrenia.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/48571682/TRPs_Links_to_schizophrenia20160904-21441-1eri0qp-libre.pdf?1473032421=\u0026response-content-disposition=attachment%3B+filename%3DTRPs_Links_to_schizophrenia.pdf\u0026Expires=1732739735\u0026Signature=XOUUuKvtRNMr9Es2FypmUS5P7tAQ-6u837VBptzXXHDrZDnYOQ7jaQ0qYfPThyEkI7BJoGkoEW47k8SmueRvvGiqHHJMEkOxJmDnaob3SJx35FWR-tjyAbJLSmxYgKGvKmkiVoiVUISOzSD407EViBtcnJ7u-bM5WMmA2yXe4pTLX69LAxkR9JYzB4sLp9ueWsLRgxeIIama57vXRY6gLcpCulCsarwTcbnFYKBT7M4OHEt5bF~ZoX5l-RVk2IP6RJA53guKIRr7p8tI90onYmby-Qlw124aaTp3j3rZu4J-z7L77~bq1g0EYEgwtZa8sQjXD6o6stwKr~QXQiUlGw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":1389,"name":"Thermoregulation","url":"https://www.academia.edu/Documents/in/Thermoregulation"},{"id":3227,"name":"Schizophrenia","url":"https://www.academia.edu/Documents/in/Schizophrenia"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain"},{"id":93942,"name":"Transient receptor potential channels","url":"https://www.academia.edu/Documents/in/Transient_receptor_potential_channels"},{"id":118582,"name":"Physical sciences","url":"https://www.academia.edu/Documents/in/Physical_sciences"},{"id":157726,"name":"Dopamine Receptors","url":"https://www.academia.edu/Documents/in/Dopamine_Receptors"},{"id":180715,"name":"Body temperature regulation","url":"https://www.academia.edu/Documents/in/Body_temperature_regulation"},{"id":204100,"name":"Capsaicin","url":"https://www.academia.edu/Documents/in/Capsaicin"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":418263,"name":"SYNAPSES","url":"https://www.academia.edu/Documents/in/SYNAPSES"},{"id":1325769,"name":"TRP Channels","url":"https://www.academia.edu/Documents/in/TRP_Channels"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"}],"urls":[{"id":7514461,"url":"http://cat.inist.fr/?aModele=afficheN\u0026cpsidt=18975251"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250633"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250633/Effect_of_subchronic_administration_of_tachykinin_antagonists_on_response_of_guinea_pigs_to_mild_and_severe_stress"><img alt="Research paper thumbnail of Effect of subchronic administration of tachykinin antagonists on response of guinea-pigs to mild and severe stress" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250633/Effect_of_subchronic_administration_of_tachykinin_antagonists_on_response_of_guinea_pigs_to_mild_and_severe_stress">Effect of subchronic administration of tachykinin antagonists on response of guinea-pigs to mild and severe stress</a></div><div class="wp-workCard_item"><span>Regulatory Peptides</span><span>, Jun 7, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The effects of subchronic subcutaneous treatment with tachykinin receptor antagonists over nine d...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The effects of subchronic subcutaneous treatment with tachykinin receptor antagonists over nine days on the repeated mild stress response induced by daily subcutaneous injections and on the severe acute stress induced by morphine withdrawal were investigated in guinea-pigs. The NK(1) receptor antagonist, L733,060, 0.25mg/kg, significantly increased locomotor activity of guinea-pigs compared with animals subjected to repeated injection of the inactive enantiomer, but inhibited Fos-like immunoreactivity (Fos-LI) in the hypothalamus. In animals subjected to the acute severe stress of naltrexone-induced morphine withdrawal, treatment with the NK(1) antagonist, L733,060, produced reductions in Fos-LI in the spinal dorsal horn, whereas those treated with the NK(3) antagonist, SSR146,977, 0.3mg/kg, had reduced Fos-LI in the dorsal horn, adrenal medulla, nucleus accumbens, ventral tegmental area and periaqueductal grey. Those animals treated with both NK(1) and NK(3) antagonists also had reduced Fos-LI in the amygdala and paraventricular nucleus of the thalamus. It was concluded that the NK(1) antagonist reduced the hypothalamic response to mild stress but the NK(3) antagonist was more effective in reducing the severe stress response to morphine withdrawal. Furthermore, combination of NK(1) and NK(3) antagonists was more effective than either antagonist in reducing the Fos-LI response to morphine withdrawal.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250633"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250633"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250633; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250633]").text(description); $(".js-view-count[data-work-id=28250633]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250633; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250633']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250633, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250633]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250633,"title":"Effect of subchronic administration of tachykinin antagonists on response of guinea-pigs to mild and severe stress","translated_title":"","metadata":{"abstract":"The effects of subchronic subcutaneous treatment with tachykinin receptor antagonists over nine days on the repeated mild stress response induced by daily subcutaneous injections and on the severe acute stress induced by morphine withdrawal were investigated in guinea-pigs. The NK(1) receptor antagonist, L733,060, 0.25mg/kg, significantly increased locomotor activity of guinea-pigs compared with animals subjected to repeated injection of the inactive enantiomer, but inhibited Fos-like immunoreactivity (Fos-LI) in the hypothalamus. In animals subjected to the acute severe stress of naltrexone-induced morphine withdrawal, treatment with the NK(1) antagonist, L733,060, produced reductions in Fos-LI in the spinal dorsal horn, whereas those treated with the NK(3) antagonist, SSR146,977, 0.3mg/kg, had reduced Fos-LI in the dorsal horn, adrenal medulla, nucleus accumbens, ventral tegmental area and periaqueductal grey. Those animals treated with both NK(1) and NK(3) antagonists also had reduced Fos-LI in the amygdala and paraventricular nucleus of the thalamus. It was concluded that the NK(1) antagonist reduced the hypothalamic response to mild stress but the NK(3) antagonist was more effective in reducing the severe stress response to morphine withdrawal. Furthermore, combination of NK(1) and NK(3) antagonists was more effective than either antagonist in reducing the Fos-LI response to morphine withdrawal.","publication_date":{"day":7,"month":6,"year":2011,"errors":{}},"publication_name":"Regulatory Peptides"},"translated_abstract":"The effects of subchronic subcutaneous treatment with tachykinin receptor antagonists over nine days on the repeated mild stress response induced by daily subcutaneous injections and on the severe acute stress induced by morphine withdrawal were investigated in guinea-pigs. The NK(1) receptor antagonist, L733,060, 0.25mg/kg, significantly increased locomotor activity of guinea-pigs compared with animals subjected to repeated injection of the inactive enantiomer, but inhibited Fos-like immunoreactivity (Fos-LI) in the hypothalamus. In animals subjected to the acute severe stress of naltrexone-induced morphine withdrawal, treatment with the NK(1) antagonist, L733,060, produced reductions in Fos-LI in the spinal dorsal horn, whereas those treated with the NK(3) antagonist, SSR146,977, 0.3mg/kg, had reduced Fos-LI in the dorsal horn, adrenal medulla, nucleus accumbens, ventral tegmental area and periaqueductal grey. Those animals treated with both NK(1) and NK(3) antagonists also had reduced Fos-LI in the amygdala and paraventricular nucleus of the thalamus. It was concluded that the NK(1) antagonist reduced the hypothalamic response to mild stress but the NK(3) antagonist was more effective in reducing the severe stress response to morphine withdrawal. Furthermore, combination of NK(1) and NK(3) antagonists was more effective than either antagonist in reducing the Fos-LI response to morphine withdrawal.","internal_url":"https://www.academia.edu/28250633/Effect_of_subchronic_administration_of_tachykinin_antagonists_on_response_of_guinea_pigs_to_mild_and_severe_stress","translated_internal_url":"","created_at":"2016-09-04T16:37:00.444-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Effect_of_subchronic_administration_of_tachykinin_antagonists_on_response_of_guinea_pigs_to_mild_and_severe_stress","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":9729,"name":"Stress","url":"https://www.academia.edu/Documents/in/Stress"},{"id":41697,"name":"Nucleus Accumbens","url":"https://www.academia.edu/Documents/in/Nucleus_Accumbens"},{"id":98707,"name":"Stress response","url":"https://www.academia.edu/Documents/in/Stress_response"},{"id":147195,"name":"Central Nervous System","url":"https://www.academia.edu/Documents/in/Central_Nervous_System"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons"},{"id":194429,"name":"Paraventricular Nucleus","url":"https://www.academia.edu/Documents/in/Paraventricular_Nucleus"},{"id":485556,"name":"Guinea Pig","url":"https://www.academia.edu/Documents/in/Guinea_Pig"},{"id":564878,"name":"Body Weight","url":"https://www.academia.edu/Documents/in/Body_Weight"},{"id":564895,"name":"Locomotor Activity","url":"https://www.academia.edu/Documents/in/Locomotor_Activity"},{"id":589853,"name":"Adrenal Gland","url":"https://www.academia.edu/Documents/in/Adrenal_Gland"},{"id":722449,"name":"Physiological Stress Markers","url":"https://www.academia.edu/Documents/in/Physiological_Stress_Markers"},{"id":767927,"name":"Ventral Tegmental Area","url":"https://www.academia.edu/Documents/in/Ventral_Tegmental_Area"},{"id":1834838,"name":"Dorsal Horn","url":"https://www.academia.edu/Documents/in/Dorsal_Horn"},{"id":1880638,"name":"Piperidines","url":"https://www.academia.edu/Documents/in/Piperidines"},{"id":2016105,"name":"Acute stress","url":"https://www.academia.edu/Documents/in/Acute_stress"},{"id":2246318,"name":"Motor activity","url":"https://www.academia.edu/Documents/in/Motor_activity"},{"id":2329699,"name":"Adrenal Medulla","url":"https://www.academia.edu/Documents/in/Adrenal_Medulla"}],"urls":[{"id":7514460,"url":"http://cat.inist.fr/?aModele=afficheN\u0026cpsidt=24199191"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250632"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250632/The_effects_of_haloperidol_treatment_on_the_distribution_of_NK1_receptor_immunoreactive_neurons_in_guinea_pig_brain"><img alt="Research paper thumbnail of The effects of haloperidol treatment on the distribution of NK1 receptor immunoreactive neurons in guinea-pig brain" class="work-thumbnail" src="https://attachments.academia-assets.com/48571680/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250632/The_effects_of_haloperidol_treatment_on_the_distribution_of_NK1_receptor_immunoreactive_neurons_in_guinea_pig_brain">The effects of haloperidol treatment on the distribution of NK1 receptor immunoreactive neurons in guinea-pig brain</a></div><div class="wp-workCard_item"><span>Neuroscience Letters</span><span>, Jul 1, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2e17546f57ff75ae0bd56bd08e405f78" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":48571680,"asset_id":28250632,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/48571680/download_file?st=MTczMjc1Nzk0Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250632"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250632"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250632; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250632]").text(description); $(".js-view-count[data-work-id=28250632]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250632; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250632']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250632, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2e17546f57ff75ae0bd56bd08e405f78" } } $('.js-work-strip[data-work-id=28250632]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250632,"title":"The effects of haloperidol treatment on the distribution of NK1 receptor immunoreactive neurons in guinea-pig brain","translated_title":"","metadata":{"grobid_abstract":"Previous studies have observed increased tachykinin NK 1 receptor immunoreactivity (NK 1 -IR) in the prefrontal cortex in subjects with schizophrenia. Since the subjects were medicated the possibility of a treatment effect could not be excluded. Thus, the present study was undertaken to determine the effect of chronic treatment with the antipsychotic drug, haloperidol, on the distribution of NK 1 -IR neurons in the guinea-pig brain. Guinea pigs were treated each day for 21 days with either haloperidol (1 mg/kg) or vehicle and the brains were then processed for immunohistochemistry using an NK 1 receptor-specific polyclonal antibody. NK 1 -IR neurons and fibres were abundant in the forebrain cortex and caudate putamen and more sparsely distributed in a number of other brain regions. The relative density of NK 1 -IR neurons was significantly increased in the forebrain cortex, but not in the caudate putamen in guinea pigs treated with haloperidol. This study has shown that haloperidol causes region-specific changes to the density of NK 1 -IR neurons. Whether these changes are related to the therapeutic effects or to the side effects of haloperidol in individuals with schizophrenia, remains to be determined.","publication_date":{"day":1,"month":7,"year":2005,"errors":{}},"publication_name":"Neuroscience 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Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":3227,"name":"Schizophrenia","url":"https://www.academia.edu/Documents/in/Schizophrenia"},{"id":8942,"name":"Treatment","url":"https://www.academia.edu/Documents/in/Treatment"},{"id":11558,"name":"Drug interactions","url":"https://www.academia.edu/Documents/in/Drug_interactions"},{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry"},{"id":28576,"name":"Prefrontal Cortex","url":"https://www.academia.edu/Documents/in/Prefrontal_Cortex"},{"id":35287,"name":"DISTRIBUTION","url":"https://www.academia.edu/Documents/in/DISTRIBUTION"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain"},{"id":175727,"name":"Quinpirole","url":"https://www.academia.edu/Documents/in/Quinpirole"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons"},{"id":251019,"name":"Haloperidol","url":"https://www.academia.edu/Documents/in/Haloperidol"},{"id":336524,"name":"Relative Density","url":"https://www.academia.edu/Documents/in/Relative_Density"},{"id":485556,"name":"Guinea Pig","url":"https://www.academia.edu/Documents/in/Guinea_Pig"},{"id":637974,"name":"Distribution","url":"https://www.academia.edu/Documents/in/Distribution-3"},{"id":698785,"name":"Side Effect","url":"https://www.academia.edu/Documents/in/Side_Effect"},{"id":956026,"name":"Somatic Cell Count","url":"https://www.academia.edu/Documents/in/Somatic_Cell_Count"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1763968,"name":"Gene Expression Regulation","url":"https://www.academia.edu/Documents/in/Gene_Expression_Regulation"},{"id":1881316,"name":"Treatment Effect","url":"https://www.academia.edu/Documents/in/Treatment_Effect"}],"urls":[{"id":7514459,"url":"http://cat.inist.fr/?aModele=afficheN\u0026cpsidt=16877086"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250631"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250631/Action_of_Phenylephrine_on_receptors"><img alt="Research paper thumbnail of Action of Phenylephrine on �-receptors" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250631/Action_of_Phenylephrine_on_receptors">Action of Phenylephrine on �-receptors</a></div><div class="wp-workCard_item"><span>Immun Cell Biol</span><span>, 1968</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250631"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span 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this, workJSON: {"id":28250631,"title":"Action of Phenylephrine on �-receptors","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":1968,"errors":{}},"publication_name":"Immun Cell Biol"},"translated_abstract":null,"internal_url":"https://www.academia.edu/28250631/Action_of_Phenylephrine_on_receptors","translated_internal_url":"","created_at":"2016-09-04T16:37:00.103-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Action_of_Phenylephrine_on_receptors","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[],"urls":[{"id":7514458,"url":"http://dx.doi.org/10.1038/icb.1968.151"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250630"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250630/Increased_plasma_catecholamines_and_locomotor_activity_induced_by_centrally_administered_substance_P_in_guinea_pigs"><img alt="Research paper thumbnail of Increased plasma catecholamines and locomotor activity induced by centrally administered substance P in guinea-pigs" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250630/Increased_plasma_catecholamines_and_locomotor_activity_induced_by_centrally_administered_substance_P_in_guinea_pigs">Increased plasma catecholamines and locomotor activity induced by centrally administered substance P in guinea-pigs</a></div><div class="wp-workCard_item"><span>Neuropharmacology</span><span>, Jul 31, 1988</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The effects on locomotor activity and plasma catecholamines of substance P, 0.5 nmol, injected in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The effects on locomotor activity and plasma catecholamines of substance P, 0.5 nmol, injected into each lateral ventricle (i.c.v.), or 1 nmol, injected into the cisterna magna of conscious guinea-pigs, were investigated. Locomotor activity was measured in cages fitted with an infra-red photocell and detector, and plasma catecholamines, were measured by HPLC with electrochemical detection. Substance P, given intraventricularly or into the cisterna magna, produced increased locomotor activity and a pattern of behavioural activity which mimicked the opiate withdrawal response, found in previous studies in this species. Levels of NA and AD in plasma were also significantly elevated after injection of substance P. These effects of substance P were relatively long-lasting, since they were present up to 1 hr after injection. The results show that the effects of centrally administered substance P in guinea-pigs are similar to those in rats. Furthermore, the results support the suggestion that substance P might be the mediator of the opiate withdrawal response in the central nervous system as has been proposed for the enteric nervous system.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250630"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250630"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250630; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250630]").text(description); $(".js-view-count[data-work-id=28250630]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250630; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250630']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250630, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250630]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250630,"title":"Increased plasma catecholamines and locomotor activity induced by centrally administered substance P in guinea-pigs","translated_title":"","metadata":{"abstract":"The effects on locomotor activity and plasma catecholamines of substance P, 0.5 nmol, injected into each lateral ventricle (i.c.v.), or 1 nmol, injected into the cisterna magna of conscious guinea-pigs, were investigated. Locomotor activity was measured in cages fitted with an infra-red photocell and detector, and plasma catecholamines, were measured by HPLC with electrochemical detection. Substance P, given intraventricularly or into the cisterna magna, produced increased locomotor activity and a pattern of behavioural activity which mimicked the opiate withdrawal response, found in previous studies in this species. Levels of NA and AD in plasma were also significantly elevated after injection of substance P. These effects of substance P were relatively long-lasting, since they were present up to 1 hr after injection. The results show that the effects of centrally administered substance P in guinea-pigs are similar to those in rats. Furthermore, the results support the suggestion that substance P might be the mediator of the opiate withdrawal response in the central nervous system as has been proposed for the enteric nervous system.","publication_date":{"day":31,"month":7,"year":1988,"errors":{}},"publication_name":"Neuropharmacology"},"translated_abstract":"The effects on locomotor activity and plasma catecholamines of substance P, 0.5 nmol, injected into each lateral ventricle (i.c.v.), or 1 nmol, injected into the cisterna magna of conscious guinea-pigs, were investigated. Locomotor activity was measured in cages fitted with an infra-red photocell and detector, and plasma catecholamines, were measured by HPLC with electrochemical detection. Substance P, given intraventricularly or into the cisterna magna, produced increased locomotor activity and a pattern of behavioural activity which mimicked the opiate withdrawal response, found in previous studies in this species. Levels of NA and AD in plasma were also significantly elevated after injection of substance P. These effects of substance P were relatively long-lasting, since they were present up to 1 hr after injection. The results show that the effects of centrally administered substance P in guinea-pigs are similar to those in rats. Furthermore, the results support the suggestion that substance P might be the mediator of the opiate withdrawal response in the central nervous system as has been proposed for the enteric nervous system.","internal_url":"https://www.academia.edu/28250630/Increased_plasma_catecholamines_and_locomotor_activity_induced_by_centrally_administered_substance_P_in_guinea_pigs","translated_internal_url":"","created_at":"2016-09-04T16:36:59.924-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Increased_plasma_catecholamines_and_locomotor_activity_induced_by_centrally_administered_substance_P_in_guinea_pigs","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":7955,"name":"Neuropharmacology","url":"https://www.academia.edu/Documents/in/Neuropharmacology"},{"id":71454,"name":"Epinephrine","url":"https://www.academia.edu/Documents/in/Epinephrine"},{"id":235189,"name":"Norepinephrine","url":"https://www.academia.edu/Documents/in/Norepinephrine"},{"id":485556,"name":"Guinea Pig","url":"https://www.academia.edu/Documents/in/Guinea_Pig"},{"id":564895,"name":"Locomotor Activity","url":"https://www.academia.edu/Documents/in/Locomotor_Activity"},{"id":612551,"name":"Substance P","url":"https://www.academia.edu/Documents/in/Substance_P"},{"id":1222887,"name":"Ratio","url":"https://www.academia.edu/Documents/in/Ratio"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1757315,"name":"Injections","url":"https://www.academia.edu/Documents/in/Injections"},{"id":2246318,"name":"Motor activity","url":"https://www.academia.edu/Documents/in/Motor_activity"}],"urls":[{"id":7514457,"url":"http://cat.inist.fr/?aModele=afficheN\u0026cpsidt=7121675"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250629"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250629/Molecular_Biological_Investigations_into_the_Role_of_the_NMDA_Receptor_in_the_Pathophysiology_of_Schizophrenia"><img alt="Research paper thumbnail of Molecular Biological Investigations into the Role of the NMDA Receptor in the Pathophysiology of Schizophrenia" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250629/Molecular_Biological_Investigations_into_the_Role_of_the_NMDA_Receptor_in_the_Pathophysiology_of_Schizophrenia">Molecular Biological Investigations into the Role of the NMDA Receptor in the Pathophysiology of Schizophrenia</a></div><div class="wp-workCard_item"><span>Aust N Z J Psychiat</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">There is increasing acceptance that schizophrenia is associated with a generalised disorder in co...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">There is increasing acceptance that schizophrenia is associated with a generalised disorder in cortical neurodevelopment. The aim of this paper is to review the evidence that this disorder may be accounted for by abnormalities in mechanisms mediated by the main family of excitatory neuroreceptors in cortical brain systems, the N-methyl-D-aspartate (NMDA) glutamatergic receptors. The neurobiological evidence is presented for an abnormality in cortical development related to synaptic pathology in schizophrenia. The unique functions of the NMDA receptor in information processing are described, especially its role in learning and memory, and in neural plasticity and brain development. It is argued that the cellular and molecular mechanisms which underlie learning and memory also govern normal brain development. Studies examining abnormalities in glutamatergic transmission in schizophrenia are reviewed. There is a substantial literature in support of the possibility that NMDA receptor abnormalities may be involved in the neurodevelopmental predisposition to schizophrenia, as well as in symptom production. Research to determine the role of the NMDA receptor in the pathophysiology of schizophrenia is warranted and now feasible. To be successful, this research will require the application of molecular biology techniques to postmortem brain tissue studies, in addition to traditional histochemical approaches.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250629"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250629"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250629; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250629]").text(description); $(".js-view-count[data-work-id=28250629]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250629; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250629']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250629, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250629]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250629,"title":"Molecular Biological Investigations into the Role of the NMDA Receptor in the Pathophysiology of Schizophrenia","translated_title":"","metadata":{"abstract":"There is increasing acceptance that schizophrenia is associated with a generalised disorder in cortical neurodevelopment. The aim of this paper is to review the evidence that this disorder may be accounted for by abnormalities in mechanisms mediated by the main family of excitatory neuroreceptors in cortical brain systems, the N-methyl-D-aspartate (NMDA) glutamatergic receptors. The neurobiological evidence is presented for an abnormality in cortical development related to synaptic pathology in schizophrenia. The unique functions of the NMDA receptor in information processing are described, especially its role in learning and memory, and in neural plasticity and brain development. It is argued that the cellular and molecular mechanisms which underlie learning and memory also govern normal brain development. Studies examining abnormalities in glutamatergic transmission in schizophrenia are reviewed. There is a substantial literature in support of the possibility that NMDA receptor abnormalities may be involved in the neurodevelopmental predisposition to schizophrenia, as well as in symptom production. Research to determine the role of the NMDA receptor in the pathophysiology of schizophrenia is warranted and now feasible. To be successful, this research will require the application of molecular biology techniques to postmortem brain tissue studies, in addition to traditional histochemical approaches.","publication_date":{"day":null,"month":null,"year":1997,"errors":{}},"publication_name":"Aust N Z J Psychiat"},"translated_abstract":"There is increasing acceptance that schizophrenia is associated with a generalised disorder in cortical neurodevelopment. The aim of this paper is to review the evidence that this disorder may be accounted for by abnormalities in mechanisms mediated by the main family of excitatory neuroreceptors in cortical brain systems, the N-methyl-D-aspartate (NMDA) glutamatergic receptors. The neurobiological evidence is presented for an abnormality in cortical development related to synaptic pathology in schizophrenia. The unique functions of the NMDA receptor in information processing are described, especially its role in learning and memory, and in neural plasticity and brain development. It is argued that the cellular and molecular mechanisms which underlie learning and memory also govern normal brain development. Studies examining abnormalities in glutamatergic transmission in schizophrenia are reviewed. There is a substantial literature in support of the possibility that NMDA receptor abnormalities may be involved in the neurodevelopmental predisposition to schizophrenia, as well as in symptom production. Research to determine the role of the NMDA receptor in the pathophysiology of schizophrenia is warranted and now feasible. To be successful, this research will require the application of molecular biology techniques to postmortem brain tissue studies, in addition to traditional histochemical approaches.","internal_url":"https://www.academia.edu/28250629/Molecular_Biological_Investigations_into_the_Role_of_the_NMDA_Receptor_in_the_Pathophysiology_of_Schizophrenia","translated_internal_url":"","created_at":"2016-09-04T16:36:59.762-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Molecular_Biological_Investigations_into_the_Role_of_the_NMDA_Receptor_in_the_Pathophysiology_of_Schizophrenia","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology"},{"id":3227,"name":"Schizophrenia","url":"https://www.academia.edu/Documents/in/Schizophrenia"},{"id":15572,"name":"Neurodevelopment","url":"https://www.academia.edu/Documents/in/Neurodevelopment"},{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression"},{"id":78467,"name":"Cerebral Cortex","url":"https://www.academia.edu/Documents/in/Cerebral_Cortex"},{"id":176503,"name":"Synaptic Transmission","url":"https://www.academia.edu/Documents/in/Synaptic_Transmission"}],"urls":[{"id":7514456,"url":"http://informahealthcare.com/doi/abs/10.3109/00048679709073795"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250628"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250628/Capsaicin_pretreatment_does_not_inhibit_the_opioid_withdrawal_response_in_guinea_pigs"><img alt="Research paper thumbnail of Capsaicin pretreatment does not inhibit the opioid withdrawal response in guinea-pigs" class="work-thumbnail" src="https://attachments.academia-assets.com/48571678/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250628/Capsaicin_pretreatment_does_not_inhibit_the_opioid_withdrawal_response_in_guinea_pigs">Capsaicin pretreatment does not inhibit the opioid withdrawal response in guinea-pigs</a></div><div class="wp-workCard_item"><span>European Journal of Pharmacology</span><span>, Dec 6, 1988</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b4fa8d4be308d351ab25bcc3808996f4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":48571678,"asset_id":28250628,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/48571678/download_file?st=MTczMjc1Nzk0Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250628"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250628"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250628; 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In vitro treatment of ileum with capsaicin, 1.5 ttmol/1 for 1 h, did not significantly affect the response to washout following 2 min contact with ME, 1 ~tmol/l, or the withdrawal response precipitated by naloxone, 1/xmol/1, following 2 min contact with morphine, 1/tmol/1, or the response to naloxone of tolerant-dependent ileum obtained from guinea-pigs treated with a total dose of 690 mg/kg of morphine over 3 days. Pretreatment of guinea-pigs with capsaicin 140 mg/kg subcutaneously (s.c.) over 4 days also did not affect the washout withdrawal response of the ileum to ME. Pretreatment of guinea-pigs with capsaicin did not affect the locomotor withdrawal response precipitated by naloxone hydrochloride 15 mg/kg s.c., 2 h after injection of morphine sulphate 15 mg/kg s.c. It was concluded that primary afferent neurones do not play an essential role in opioid withdrawal responses. Opioid withdrawal; Capsaicin; Morphine; Ileum (guinea-pig); Locomotor activity 0014-2999/88/$03.50","publication_date":{"day":6,"month":12,"year":1988,"errors":{}},"publication_name":"European Journal of Pharmacology","grobid_abstract_attachment_id":48571678},"translated_abstract":null,"internal_url":"https://www.academia.edu/28250628/Capsaicin_pretreatment_does_not_inhibit_the_opioid_withdrawal_response_in_guinea_pigs","translated_internal_url":"","created_at":"2016-09-04T16:36:59.608-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":48571678,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/48571678/thumbnails/1.jpg","file_name":"0014-2999_2888_2990257-920160904-6256-1en59o.pdf","download_url":"https://www.academia.edu/attachments/48571678/download_file?st=MTczMjc1Nzk0Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Capsaicin_pretreatment_does_not_inhibit.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/48571678/0014-2999_2888_2990257-920160904-6256-1en59o-libre.pdf?1473032418=\u0026response-content-disposition=attachment%3B+filename%3DCapsaicin_pretreatment_does_not_inhibit.pdf\u0026Expires=1732739736\u0026Signature=FJhLnocMwfZKTGyAVkbd-aBF-GxcPOrAE4UIwoglhSkTw-XfOSuZPbsOr~NGrGiWpCTGejGJ4Zn1duXr89S6ewQQyabtumFgp~MvyhiAr~6RDuBwjuWpDfj6NREFd~Z0zLi~YsYmng4L8NVJoEYMeeAp3YA4TcKSIRi3vrm4MFkwvx6W2mNZMg24S04dYkICM8trfsJbNBM4QIbDqYLUlef5jD-5ZO1esfj~YS7UNGeCygxer5XNmIIVaxwz5jXfkAlIZOEowruayutilMXVIAYhv1tJN0gQqTloMP8eEhvQj7YdD~keE8o-S-5BMM-iHAw~KtbwvyqG89PKQthxwQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Capsaicin_pretreatment_does_not_inhibit_the_opioid_withdrawal_response_in_guinea_pigs","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[{"id":48571678,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/48571678/thumbnails/1.jpg","file_name":"0014-2999_2888_2990257-920160904-6256-1en59o.pdf","download_url":"https://www.academia.edu/attachments/48571678/download_file?st=MTczMjc1Nzk0Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Capsaicin_pretreatment_does_not_inhibit.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/48571678/0014-2999_2888_2990257-920160904-6256-1en59o-libre.pdf?1473032418=\u0026response-content-disposition=attachment%3B+filename%3DCapsaicin_pretreatment_does_not_inhibit.pdf\u0026Expires=1732739736\u0026Signature=FJhLnocMwfZKTGyAVkbd-aBF-GxcPOrAE4UIwoglhSkTw-XfOSuZPbsOr~NGrGiWpCTGejGJ4Zn1duXr89S6ewQQyabtumFgp~MvyhiAr~6RDuBwjuWpDfj6NREFd~Z0zLi~YsYmng4L8NVJoEYMeeAp3YA4TcKSIRi3vrm4MFkwvx6W2mNZMg24S04dYkICM8trfsJbNBM4QIbDqYLUlef5jD-5ZO1esfj~YS7UNGeCygxer5XNmIIVaxwz5jXfkAlIZOEowruayutilMXVIAYhv1tJN0gQqTloMP8eEhvQj7YdD~keE8o-S-5BMM-iHAw~KtbwvyqG89PKQthxwQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":9032,"name":"Interaction","url":"https://www.academia.edu/Documents/in/Interaction"},{"id":59370,"name":"In Vitro","url":"https://www.academia.edu/Documents/in/In_Vitro"},{"id":204100,"name":"Capsaicin","url":"https://www.academia.edu/Documents/in/Capsaicin"},{"id":218374,"name":"Morphine","url":"https://www.academia.edu/Documents/in/Morphine"},{"id":336223,"name":"Digestive System","url":"https://www.academia.edu/Documents/in/Digestive_System"},{"id":556021,"name":"Muscle contraction","url":"https://www.academia.edu/Documents/in/Muscle_contraction"},{"id":783432,"name":"Biological activity","url":"https://www.academia.edu/Documents/in/Biological_activity"},{"id":1901112,"name":"Ileum","url":"https://www.academia.edu/Documents/in/Ileum"},{"id":2246318,"name":"Motor activity","url":"https://www.academia.edu/Documents/in/Motor_activity"}],"urls":[{"id":7514455,"url":"http://cat.inist.fr/?aModele=afficheN\u0026cpsidt=7260123"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250627"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250627/Distribution_of_substance_P_like_immunoreactivity_in_guinea_pig_central_nervous_system"><img alt="Research paper thumbnail of Distribution of substance P-like immunoreactivity in guinea pig central nervous system" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250627/Distribution_of_substance_P_like_immunoreactivity_in_guinea_pig_central_nervous_system">Distribution of substance P-like immunoreactivity in guinea pig central nervous system</a></div><div class="wp-workCard_item"><span>Brain Res Bull</span><span>, 1992</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250627"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250627"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250627; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250627]").text(description); $(".js-view-count[data-work-id=28250627]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250627; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250627']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250627, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250626"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250626/The_role_of_prostaglandins_in_chemically_induced_inflammation"><img alt="Research paper thumbnail of The role of prostaglandins in chemically induced inflammation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250626/The_role_of_prostaglandins_in_chemically_induced_inflammation">The role of prostaglandins in chemically induced inflammation</a></div><div class="wp-workCard_item"><span>British journal of experimental pathology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dye leakage in rats, produced by intracutaneous injections of irritants into the abdominal skin, ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dye leakage in rats, produced by intracutaneous injections of irritants into the abdominal skin, was quantitated using the Evans blue technique of Harada et al. (1971). In control rats and in rats pretreated with indomethacin (an inhibitor of prostaglandin synthesis) concentration-response lines were obtained for 5-hydroxytryptamine, histamine, bradykinin and prostaglandin E1, bradykinin in the presence of prostaglandin E1 (10-6 M), adenosine-5&amp;#39;-triphosphate, compound 48/80, capsaicin and silver nitrate. In rats pretreated with indomethacin the dye leakage responses to histamine, prostaglandin E1, adenosine-5&amp;#39;-triphosphate and silver nitrate were significantly reduced, but no significant changes were observed in the responses to the other irritants. It is suggested that part of the action of histamine, adenosine-5&amp;#39;-triphosphate and prostagland in E1 is produced indirectly by releaseor stimulation of the synthesis of prostaglandins or their precursors. These results might have important implications in the understanding of the inflammatory response.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250626"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250626"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250626; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250626]").text(description); $(".js-view-count[data-work-id=28250626]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250626; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250626']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250626, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250626]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250626,"title":"The role of prostaglandins in chemically induced inflammation","translated_title":"","metadata":{"abstract":"Dye leakage in rats, produced by intracutaneous injections of irritants into the abdominal skin, was quantitated using the Evans blue technique of Harada et al. (1971). In control rats and in rats pretreated with indomethacin (an inhibitor of prostaglandin synthesis) concentration-response lines were obtained for 5-hydroxytryptamine, histamine, bradykinin and prostaglandin E1, bradykinin in the presence of prostaglandin E1 (10-6 M), adenosine-5\u0026amp;#39;-triphosphate, compound 48/80, capsaicin and silver nitrate. In rats pretreated with indomethacin the dye leakage responses to histamine, prostaglandin E1, adenosine-5\u0026amp;#39;-triphosphate and silver nitrate were significantly reduced, but no significant changes were observed in the responses to the other irritants. It is suggested that part of the action of histamine, adenosine-5\u0026amp;#39;-triphosphate and prostagland in E1 is produced indirectly by releaseor stimulation of the synthesis of prostaglandins or their precursors. These results might have important implications in the understanding of the inflammatory response.","publication_name":"British journal of experimental pathology"},"translated_abstract":"Dye leakage in rats, produced by intracutaneous injections of irritants into the abdominal skin, was quantitated using the Evans blue technique of Harada et al. (1971). In control rats and in rats pretreated with indomethacin (an inhibitor of prostaglandin synthesis) concentration-response lines were obtained for 5-hydroxytryptamine, histamine, bradykinin and prostaglandin E1, bradykinin in the presence of prostaglandin E1 (10-6 M), adenosine-5\u0026amp;#39;-triphosphate, compound 48/80, capsaicin and silver nitrate. In rats pretreated with indomethacin the dye leakage responses to histamine, prostaglandin E1, adenosine-5\u0026amp;#39;-triphosphate and silver nitrate were significantly reduced, but no significant changes were observed in the responses to the other irritants. It is suggested that part of the action of histamine, adenosine-5\u0026amp;#39;-triphosphate and prostagland in E1 is produced indirectly by releaseor stimulation of the synthesis of prostaglandins or their precursors. These results might have important implications in the understanding of the inflammatory response.","internal_url":"https://www.academia.edu/28250626/The_role_of_prostaglandins_in_chemically_induced_inflammation","translated_internal_url":"","created_at":"2016-09-04T16:36:59.387-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_role_of_prostaglandins_in_chemically_induced_inflammation","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":663253,"name":"Silver Nitrate","url":"https://www.academia.edu/Documents/in/Silver_Nitrate"},{"id":708670,"name":"Prostaglandins","url":"https://www.academia.edu/Documents/in/Prostaglandins"},{"id":1816594,"name":"Adenosine Triphosphate","url":"https://www.academia.edu/Documents/in/Adenosine_Triphosphate"},{"id":1866509,"name":"Indomethacin","url":"https://www.academia.edu/Documents/in/Indomethacin"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250625"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250625/Mast_cell_degranulation_and_increased_vascular_permeability_induced_by_therapeutic_ultrasound_in_the_rat_ankle_joint"><img alt="Research paper thumbnail of Mast cell degranulation and increased vascular permeability induced by 'therapeutic' ultrasound in the rat ankle joint" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250625/Mast_cell_degranulation_and_increased_vascular_permeability_induced_by_therapeutic_ultrasound_in_the_rat_ankle_joint">Mast cell degranulation and increased vascular permeability induced by 'therapeutic' ultrasound in the rat ankle joint</a></div><div class="wp-workCard_item"><span>British journal of experimental pathology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ultrasound at frequencies between 0.75 and 3.0 MHz is widely used in the treatment of musculoskel...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ultrasound at frequencies between 0.75 and 3.0 MHz is widely used in the treatment of musculoskeletal injuries in human and veterinary patients. The mechanisms by which ultrasound affects clinical recovery are, however, incompletely understood. At present no clear rationale has been evolved to guide the selection and use of all the factors comprising the dosage of ultrasound in treatment designed to encourage tissue healing. In the present study applications of ultrasound considered to be therapeutic caused a small but significant increase in vascular permeability in the hindpaw ankles of rats in vivo which was abolished by pre-treatment of the rats with a combination of a histamine H1-receptor antagonist and a serotonin antagonist. Histological sections from rat ankles showed that ultrasound also caused a significant increase in the number of degranulated mast cells above control values. Since mast cells contain histamine, low concentrations of which have been associated with healing, the finding that ultrasound produces mast cell degranulation and evidence of histamine release provides a new direction for investigation of the mechanism of its therapeutic action, and for determination of appropriate regimens of treatment.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250625"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250625"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250625; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250625]").text(description); $(".js-view-count[data-work-id=28250625]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250625; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250625']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250625, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250625]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250625,"title":"Mast cell degranulation and increased vascular permeability induced by 'therapeutic' ultrasound in the rat ankle joint","translated_title":"","metadata":{"abstract":"Ultrasound at frequencies between 0.75 and 3.0 MHz is widely used in the treatment of musculoskeletal injuries in human and veterinary patients. The mechanisms by which ultrasound affects clinical recovery are, however, incompletely understood. At present no clear rationale has been evolved to guide the selection and use of all the factors comprising the dosage of ultrasound in treatment designed to encourage tissue healing. In the present study applications of ultrasound considered to be therapeutic caused a small but significant increase in vascular permeability in the hindpaw ankles of rats in vivo which was abolished by pre-treatment of the rats with a combination of a histamine H1-receptor antagonist and a serotonin antagonist. Histological sections from rat ankles showed that ultrasound also caused a significant increase in the number of degranulated mast cells above control values. Since mast cells contain histamine, low concentrations of which have been associated with healing, the finding that ultrasound produces mast cell degranulation and evidence of histamine release provides a new direction for investigation of the mechanism of its therapeutic action, and for determination of appropriate regimens of treatment.","publication_name":"British journal of experimental pathology"},"translated_abstract":"Ultrasound at frequencies between 0.75 and 3.0 MHz is widely used in the treatment of musculoskeletal injuries in human and veterinary patients. The mechanisms by which ultrasound affects clinical recovery are, however, incompletely understood. At present no clear rationale has been evolved to guide the selection and use of all the factors comprising the dosage of ultrasound in treatment designed to encourage tissue healing. In the present study applications of ultrasound considered to be therapeutic caused a small but significant increase in vascular permeability in the hindpaw ankles of rats in vivo which was abolished by pre-treatment of the rats with a combination of a histamine H1-receptor antagonist and a serotonin antagonist. Histological sections from rat ankles showed that ultrasound also caused a significant increase in the number of degranulated mast cells above control values. Since mast cells contain histamine, low concentrations of which have been associated with healing, the finding that ultrasound produces mast cell degranulation and evidence of histamine release provides a new direction for investigation of the mechanism of its therapeutic action, and for determination of appropriate regimens of treatment.","internal_url":"https://www.academia.edu/28250625/Mast_cell_degranulation_and_increased_vascular_permeability_induced_by_therapeutic_ultrasound_in_the_rat_ankle_joint","translated_internal_url":"","created_at":"2016-09-04T16:36:59.247-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Mast_cell_degranulation_and_increased_vascular_permeability_induced_by_therapeutic_ultrasound_in_the_rat_ankle_joint","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":15570,"name":"Mast Cells","url":"https://www.academia.edu/Documents/in/Mast_Cells"},{"id":118812,"name":"Ultrasonics","url":"https://www.academia.edu/Documents/in/Ultrasonics"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":670043,"name":"Joints","url":"https://www.academia.edu/Documents/in/Joints"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250624"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250624/The_effects_of_selective_dopamine_D_1_and_D_2_antagonists_on_the_locomotor_response_and_brain_monoamine_changes_induced_by_naloxone_precipitated_morphine_withdrawal_in_guinea_pigs"><img alt="Research paper thumbnail of The effects of selective dopamine D-1 and D-2 antagonists on the locomotor response and brain monoamine changes induced by naloxone-precipitated morphine withdrawal in guinea pigs" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250624/The_effects_of_selective_dopamine_D_1_and_D_2_antagonists_on_the_locomotor_response_and_brain_monoamine_changes_induced_by_naloxone_precipitated_morphine_withdrawal_in_guinea_pigs">The effects of selective dopamine D-1 and D-2 antagonists on the locomotor response and brain monoamine changes induced by naloxone-precipitated morphine withdrawal in guinea pigs</a></div><div class="wp-workCard_item"><span>Progress in clinical and biological research</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250624"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250624"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250624; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250624]").text(description); $(".js-view-count[data-work-id=28250624]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250624; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250624']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250624, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250624]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250624,"title":"The effects of selective dopamine D-1 and D-2 antagonists on the locomotor response and brain monoamine changes induced by naloxone-precipitated morphine withdrawal in guinea pigs","translated_title":"","metadata":{"publication_name":"Progress in clinical and biological research"},"translated_abstract":null,"internal_url":"https://www.academia.edu/28250624/The_effects_of_selective_dopamine_D_1_and_D_2_antagonists_on_the_locomotor_response_and_brain_monoamine_changes_induced_by_naloxone_precipitated_morphine_withdrawal_in_guinea_pigs","translated_internal_url":"","created_at":"2016-09-04T16:36:59.147-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_effects_of_selective_dopamine_D_1_and_D_2_antagonists_on_the_locomotor_response_and_brain_monoamine_changes_induced_by_naloxone_precipitated_morphine_withdrawal_in_guinea_pigs","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":51566,"name":"Dopamine","url":"https://www.academia.edu/Documents/in/Dopamine"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain"},{"id":157726,"name":"Dopamine Receptors","url":"https://www.academia.edu/Documents/in/Dopamine_Receptors"},{"id":218374,"name":"Morphine","url":"https://www.academia.edu/Documents/in/Morphine"},{"id":1128472,"name":"Naloxone","url":"https://www.academia.edu/Documents/in/Naloxone"},{"id":2246318,"name":"Motor activity","url":"https://www.academia.edu/Documents/in/Motor_activity"},{"id":2410525,"name":"Sulpiride","url":"https://www.academia.edu/Documents/in/Sulpiride"},{"id":2410542,"name":"Dopamine antagonists","url":"https://www.academia.edu/Documents/in/Dopamine_antagonists"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250623"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250623/The_acute_effects_of_capsaicin_on_the_cardiovascular_system"><img alt="Research paper thumbnail of The acute effects of capsaicin on the cardiovascular system" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250623/The_acute_effects_of_capsaicin_on_the_cardiovascular_system">The acute effects of capsaicin on the cardiovascular system</a></div><div class="wp-workCard_item"><span>Acta Physiologica Hungarica</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Arterial blood pressure and heart rate were recorded from male Wistar rats anaesthetized with ure...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Arterial blood pressure and heart rate were recorded from male Wistar rats anaesthetized with urethane. Intravenous injection of capsaicin, 1 microgram, produced a reproducible triphasic effect on blood pressure, comprising an initial fall in blood pressure and heart rate, followed by a transient and then a sustained pressor response. The depressor response and bradycardia were abolished by vagal section. The transient pressor response was altered in shape by hexamethonium. Slow intravenous infusion of capsaicin, 50 micrograms over 12 min, produced only a sustained pressor response accompanied by tachycardia, which was resistant to hexamethonium but abolished by morphine and pithing. Responses to both 1 microgram injection and 50 micrograms infusion of capsaicin were unaffected by the SP antagonist, spantide, but were abolished by capsaicin pretreatment of the rats. Capsaicin induces complex effects on the cardiovascular system, the nature of which varies with the dose and speed of administration.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250623"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250623"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250623; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250623]").text(description); $(".js-view-count[data-work-id=28250623]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250623; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250623']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250623, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250623]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250623,"title":"The acute effects of capsaicin on the cardiovascular system","translated_title":"","metadata":{"abstract":"Arterial blood pressure and heart rate were recorded from male Wistar rats anaesthetized with urethane. Intravenous injection of capsaicin, 1 microgram, produced a reproducible triphasic effect on blood pressure, comprising an initial fall in blood pressure and heart rate, followed by a transient and then a sustained pressor response. The depressor response and bradycardia were abolished by vagal section. The transient pressor response was altered in shape by hexamethonium. Slow intravenous infusion of capsaicin, 50 micrograms over 12 min, produced only a sustained pressor response accompanied by tachycardia, which was resistant to hexamethonium but abolished by morphine and pithing. Responses to both 1 microgram injection and 50 micrograms infusion of capsaicin were unaffected by the SP antagonist, spantide, but were abolished by capsaicin pretreatment of the rats. Capsaicin induces complex effects on the cardiovascular system, the nature of which varies with the dose and speed of administration.","publication_name":"Acta Physiologica Hungarica"},"translated_abstract":"Arterial blood pressure and heart rate were recorded from male Wistar rats anaesthetized with urethane. Intravenous injection of capsaicin, 1 microgram, produced a reproducible triphasic effect on blood pressure, comprising an initial fall in blood pressure and heart rate, followed by a transient and then a sustained pressor response. The depressor response and bradycardia were abolished by vagal section. The transient pressor response was altered in shape by hexamethonium. Slow intravenous infusion of capsaicin, 50 micrograms over 12 min, produced only a sustained pressor response accompanied by tachycardia, which was resistant to hexamethonium but abolished by morphine and pithing. Responses to both 1 microgram injection and 50 micrograms infusion of capsaicin were unaffected by the SP antagonist, spantide, but were abolished by capsaicin pretreatment of the rats. Capsaicin induces complex effects on the cardiovascular system, the nature of which varies with the dose and speed of administration.","internal_url":"https://www.academia.edu/28250623/The_acute_effects_of_capsaicin_on_the_cardiovascular_system","translated_internal_url":"","created_at":"2016-09-04T16:36:59.030-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_acute_effects_of_capsaicin_on_the_cardiovascular_system","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure"},{"id":131298,"name":"Heart rate","url":"https://www.academia.edu/Documents/in/Heart_rate"},{"id":204100,"name":"Capsaicin","url":"https://www.academia.edu/Documents/in/Capsaicin"},{"id":218374,"name":"Morphine","url":"https://www.academia.edu/Documents/in/Morphine"},{"id":230879,"name":"Denervation","url":"https://www.academia.edu/Documents/in/Denervation"},{"id":312834,"name":"Cardiovascular system","url":"https://www.academia.edu/Documents/in/Cardiovascular_system"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":612551,"name":"Substance P","url":"https://www.academia.edu/Documents/in/Substance_P"},{"id":1748602,"name":"Vagus Nerve","url":"https://www.academia.edu/Documents/in/Vagus_Nerve"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250622"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250622/Acute_effects_of_morphine_on_Substance_P_concentrations_in_microdissected_regions_of_guinea_pig_brain"><img alt="Research paper thumbnail of Acute effects of morphine on Substance P concentrations in microdissected regions of guinea-pig brain" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250622/Acute_effects_of_morphine_on_Substance_P_concentrations_in_microdissected_regions_of_guinea_pig_brain">Acute effects of morphine on Substance P concentrations in microdissected regions of guinea-pig brain</a></div><div class="wp-workCard_item"><span>Behavioural pharmacology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The present study investigated the effects of acute morphine treatment and of naloxone-induced mo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The present study investigated the effects of acute morphine treatment and of naloxone-induced morphine withdrawal on Substance P (SP) concentrations in microdissected regions of the guinea-pig brain. Guinea-pigs, which were treated with a single dose of morphine sulphate (15mg/kg s.c.), received naloxone hydrochloride (15mg/kg s.c.) after 2h. Control animals received injections of saline, saline and naloxone, or morphine and saline. Locomotor and behavioural activities were measured throughout the experiments. Animals were killed 0.5h after naloxone administration, brains were removed and SP-like immunoreactivity (SP-LI) was measured in microdissected regions using radioimmunoassay. Morphine significantly increased the concentration of SP-LI in the central nucleus of the amygdala, but reduced SP-LI overall in the mesencephalon. Guinea-pigs pretreated with morphine and then given naloxone to precipitate withdrawal showed no change in SP-LI concentrations in any brain region, compare...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250622"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250622"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250622; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250622]").text(description); $(".js-view-count[data-work-id=28250622]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250622; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250622']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250622, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250622]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250622,"title":"Acute effects of morphine on Substance P concentrations in microdissected regions of guinea-pig brain","translated_title":"","metadata":{"abstract":"The present study investigated the effects of acute morphine treatment and of naloxone-induced morphine withdrawal on Substance P (SP) concentrations in microdissected regions of the guinea-pig brain. Guinea-pigs, which were treated with a single dose of morphine sulphate (15mg/kg s.c.), received naloxone hydrochloride (15mg/kg s.c.) after 2h. Control animals received injections of saline, saline and naloxone, or morphine and saline. Locomotor and behavioural activities were measured throughout the experiments. Animals were killed 0.5h after naloxone administration, brains were removed and SP-like immunoreactivity (SP-LI) was measured in microdissected regions using radioimmunoassay. Morphine significantly increased the concentration of SP-LI in the central nucleus of the amygdala, but reduced SP-LI overall in the mesencephalon. Guinea-pigs pretreated with morphine and then given naloxone to precipitate withdrawal showed no change in SP-LI concentrations in any brain region, compare...","publication_name":"Behavioural pharmacology"},"translated_abstract":"The present study investigated the effects of acute morphine treatment and of naloxone-induced morphine withdrawal on Substance P (SP) concentrations in microdissected regions of the guinea-pig brain. Guinea-pigs, which were treated with a single dose of morphine sulphate (15mg/kg s.c.), received naloxone hydrochloride (15mg/kg s.c.) after 2h. Control animals received injections of saline, saline and naloxone, or morphine and saline. Locomotor and behavioural activities were measured throughout the experiments. Animals were killed 0.5h after naloxone administration, brains were removed and SP-like immunoreactivity (SP-LI) was measured in microdissected regions using radioimmunoassay. Morphine significantly increased the concentration of SP-LI in the central nucleus of the amygdala, but reduced SP-LI overall in the mesencephalon. Guinea-pigs pretreated with morphine and then given naloxone to precipitate withdrawal showed no change in SP-LI concentrations in any brain region, compare...","internal_url":"https://www.academia.edu/28250622/Acute_effects_of_morphine_on_Substance_P_concentrations_in_microdissected_regions_of_guinea_pig_brain","translated_internal_url":"","created_at":"2016-09-04T16:36:58.917-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Acute_effects_of_morphine_on_Substance_P_concentrations_in_microdissected_regions_of_guinea_pig_brain","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":1115963,"name":"Behavioural Pharmacology","url":"https://www.academia.edu/Documents/in/Behavioural_Pharmacology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250621"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250621/The_Effect_of_Substance_P_Antiserum_on_Responses_of_Guinea_Pig_Isolated_Ileum_to_Substance_P_and_Acetylcholine"><img alt="Research paper thumbnail of The Effect of Substance P Antiserum on Responses of Guinea-Pig Isolated Ileum to Substance P and Acetylcholine" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250621/The_Effect_of_Substance_P_Antiserum_on_Responses_of_Guinea_Pig_Isolated_Ileum_to_Substance_P_and_Acetylcholine">The Effect of Substance P Antiserum on Responses of Guinea-Pig Isolated Ileum to Substance P and Acetylcholine</a></div><div class="wp-workCard_item"><span>Substance P and Neurokinins</span><span>, 1987</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250621"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250621"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250621; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250621]").text(description); $(".js-view-count[data-work-id=28250621]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250621; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250621']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250621, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250621]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250621,"title":"The Effect of Substance P Antiserum on Responses of Guinea-Pig Isolated Ileum to Substance P and Acetylcholine","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":1987,"errors":{}},"publication_name":"Substance P and Neurokinins"},"translated_abstract":null,"internal_url":"https://www.academia.edu/28250621/The_Effect_of_Substance_P_Antiserum_on_Responses_of_Guinea_Pig_Isolated_Ileum_to_Substance_P_and_Acetylcholine","translated_internal_url":"","created_at":"2016-09-04T16:36:58.800-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_Effect_of_Substance_P_Antiserum_on_Responses_of_Guinea_Pig_Isolated_Ileum_to_Substance_P_and_Acetylcholine","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250620"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250620/Effects_of_neonatal_treatment_with_the_TRPV1_agonist_capsaicin_on_adult_rat_brain_and_behaviour"><img alt="Research paper thumbnail of Effects of neonatal treatment with the TRPV1 agonist, capsaicin, on adult rat brain and behaviour" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250620/Effects_of_neonatal_treatment_with_the_TRPV1_agonist_capsaicin_on_adult_rat_brain_and_behaviour">Effects of neonatal treatment with the TRPV1 agonist, capsaicin, on adult rat brain and behaviour</a></div><div class="wp-workCard_item"><span>Behavioural brain research</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Treatment of neonatal rats with the transient receptor potential vanilloid 1 (TRPV1) channel agon...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Treatment of neonatal rats with the transient receptor potential vanilloid 1 (TRPV1) channel agonist, capsaicin, produces life-long loss of sensory neurons expressing TRPV1 channels. Previously it was shown that rats treated on day 2 of life with capsaicin had behavioural hyperactivity in a novel environment at 5-7 weeks of age and brain changes reminiscent of those found in subjects with schizophrenia. The objective of the present study was to investigate brain and behavioural responses of adult rats treated as neonates with capsaicin. It was found that the brain changes found at 5-7 weeks in rats treated as neonates with capsaicin persisted into adulthood (12 weeks) but were less in older rats (16-18 weeks). Increased prepulse inhibition (PPI) of acoustic startle was found in these rats at 8 and 12 weeks of age rather than the deficit commonly found in animal models of schizophrenia. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250637"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250637/Tachykinins_and_neuropsychiatric_disorders"><img alt="Research paper thumbnail of Tachykinins and neuropsychiatric disorders" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250637/Tachykinins_and_neuropsychiatric_disorders">Tachykinins and neuropsychiatric disorders</a></div><div class="wp-workCard_item"><span>Current drug targets</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The classical tachykinins, substance P, neurokinin A and neurokinin B are predominantly found in ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The classical tachykinins, substance P, neurokinin A and neurokinin B are predominantly found in the nervous system where they act as neurotransmitters and neuromodulators. Their respective preferred receptors are NK1, NK2, and NK3 receptors. The presence of substance P in nociceptive primary afferent neurons, electrophysiological studies showing that it activated neurons in the dorsal horn of the spinal cord, and behavioral studies in animals, supported the concept that substance P was an important transmitter in the nociceptive pathway. It was therefore surprising that non-peptide NK1 receptor antagonists were ineffective as analgesics in clinical pain conditions. Nevertheless, the discovery that NK1 receptor antagonists had antidepressant activity led to renewed interest in these antagonists. It is disappointing that clinical trials of MK869 (aprepitant) for depression were suspended. 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Their respective preferred receptors are NK1, NK2, and NK3 receptors. The presence of substance P in nociceptive primary afferent neurons, electrophysiological studies showing that it activated neurons in the dorsal horn of the spinal cord, and behavioral studies in animals, supported the concept that substance P was an important transmitter in the nociceptive pathway. It was therefore surprising that non-peptide NK1 receptor antagonists were ineffective as analgesics in clinical pain conditions. Nevertheless, the discovery that NK1 receptor antagonists had antidepressant activity led to renewed interest in these antagonists. It is disappointing that clinical trials of MK869 (aprepitant) for depression were suspended. The future of NK1 receptor antagonists as antidepressant drugs will depend on the outcome of clinical trials with other NK1 receptor antagonists. NK1 receptor antagonists were also found to be effective antiemetics, and aprepitant has recently become available for the treatment of chemotherapy induced emesis. Although less is known of the potential of NK2 and NK3 receptor antagonists, recent trials of NK3 receptor antagonists have shown efficacy in schizophrenia. The discovery of a new family of tachykinins, the hemokinins and endokinins, which acts on NK1 receptors and has potent effects on immune cells, has implications for the clinical use of NK1 receptor antagonists. Thus specific therapeutic strategies may be required to enable NK1 receptor antagonists to be introduced for treatment of neuropsychiatric disorders.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250636"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250636"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250636; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250636]").text(description); $(".js-view-count[data-work-id=28250636]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250636; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250636']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250636, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250636]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250636,"title":"Tachykinins and Neuropsychiatric Disorders","translated_title":"","metadata":{"abstract":"The classical tachykinins, substance P, neurokinin A and neurokinin B are predominantly found in the nervous system where they act as neurotransmitters and neuromodulators. 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NK1 receptor antagonists were also found to be effective antiemetics, and aprepitant has recently become available for the treatment of chemotherapy induced emesis. Although less is known of the potential of NK2 and NK3 receptor antagonists, recent trials of NK3 receptor antagonists have shown efficacy in schizophrenia. The discovery of a new family of tachykinins, the hemokinins and endokinins, which acts on NK1 receptors and has potent effects on immune cells, has implications for the clinical use of NK1 receptor antagonists. Thus specific therapeutic strategies may be required to enable NK1 receptor antagonists to be introduced for treatment of neuropsychiatric disorders.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Current Drug Targets"},"translated_abstract":"The classical tachykinins, substance P, neurokinin A and neurokinin B are predominantly found in the nervous system where they act as neurotransmitters and neuromodulators. 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NK1 receptor antagonists were also found to be effective antiemetics, and aprepitant has recently become available for the treatment of chemotherapy induced emesis. Although less is known of the potential of NK2 and NK3 receptor antagonists, recent trials of NK3 receptor antagonists have shown efficacy in schizophrenia. The discovery of a new family of tachykinins, the hemokinins and endokinins, which acts on NK1 receptors and has potent effects on immune cells, has implications for the clinical use of NK1 receptor antagonists. Thus specific therapeutic strategies may be required to enable NK1 receptor antagonists to be introduced for treatment of neuropsychiatric disorders.","internal_url":"https://www.academia.edu/28250636/Tachykinins_and_Neuropsychiatric_Disorders","translated_internal_url":"","created_at":"2016-09-04T16:37:44.726-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Tachykinins_and_Neuropsychiatric_Disorders","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":171144,"name":"Mental Disorders","url":"https://www.academia.edu/Documents/in/Mental_Disorders"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250634"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250634/TRPs_Links_to_schizophrenia"><img alt="Research paper thumbnail of TRP's: Links to schizophrenia?" class="work-thumbnail" src="https://attachments.academia-assets.com/48571682/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250634/TRPs_Links_to_schizophrenia">TRP's: Links to schizophrenia?</a></div><div class="wp-workCard_item"><span>Biochimica Et Biophysica Acta Molecular Basis of Disease</span><span>, Aug 31, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3257cdeec0a2600ace5e591ea6f6fed0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":48571682,"asset_id":28250634,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/48571682/download_file?st=MTczMjc1Nzk0Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250634"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250634"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250634; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250634]").text(description); $(".js-view-count[data-work-id=28250634]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250634; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250634']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250634, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3257cdeec0a2600ace5e591ea6f6fed0" } } $('.js-work-strip[data-work-id=28250634]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250634,"title":"TRP's: Links to schizophrenia?","translated_title":"","metadata":{"grobid_abstract":"Schizophrenia is a chronic psychiatric disorder the cause of which is unknown. It is considered to be a neurodevelopmental disorder that results from an interaction of genetic and environmental factors. Direct evidence for links between schizophrenia and TRP channels is lacking. However, several aspects of the pathophysiology of the disorder point to a possible involvement of TRP channels. In this review evidence for links between TRP channels and schizophrenia with respect to neurodevelopment, dopaminergic and cannabinoid systems, thermoregulation, and sensory processes, is discussed. Investigation of these links holds the prospect of a new understanding of schizophrenia with resultant therapeutic advances.","publication_date":{"day":31,"month":8,"year":2007,"errors":{}},"publication_name":"Biochimica Et Biophysica Acta Molecular Basis of Disease","grobid_abstract_attachment_id":48571682},"translated_abstract":null,"internal_url":"https://www.academia.edu/28250634/TRPs_Links_to_schizophrenia","translated_internal_url":"","created_at":"2016-09-04T16:37:00.655-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":48571682,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/48571682/thumbnails/1.jpg","file_name":"TRPs_Links_to_schizophrenia20160904-21441-1eri0qp.pdf","download_url":"https://www.academia.edu/attachments/48571682/download_file?st=MTczMjc1Nzk0Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"TRPs_Links_to_schizophrenia.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/48571682/TRPs_Links_to_schizophrenia20160904-21441-1eri0qp-libre.pdf?1473032421=\u0026response-content-disposition=attachment%3B+filename%3DTRPs_Links_to_schizophrenia.pdf\u0026Expires=1732739735\u0026Signature=XOUUuKvtRNMr9Es2FypmUS5P7tAQ-6u837VBptzXXHDrZDnYOQ7jaQ0qYfPThyEkI7BJoGkoEW47k8SmueRvvGiqHHJMEkOxJmDnaob3SJx35FWR-tjyAbJLSmxYgKGvKmkiVoiVUISOzSD407EViBtcnJ7u-bM5WMmA2yXe4pTLX69LAxkR9JYzB4sLp9ueWsLRgxeIIama57vXRY6gLcpCulCsarwTcbnFYKBT7M4OHEt5bF~ZoX5l-RVk2IP6RJA53guKIRr7p8tI90onYmby-Qlw124aaTp3j3rZu4J-z7L77~bq1g0EYEgwtZa8sQjXD6o6stwKr~QXQiUlGw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"TRPs_Links_to_schizophrenia","translated_slug":"","page_count":38,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[{"id":48571682,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/48571682/thumbnails/1.jpg","file_name":"TRPs_Links_to_schizophrenia20160904-21441-1eri0qp.pdf","download_url":"https://www.academia.edu/attachments/48571682/download_file?st=MTczMjc1Nzk0Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"TRPs_Links_to_schizophrenia.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/48571682/TRPs_Links_to_schizophrenia20160904-21441-1eri0qp-libre.pdf?1473032421=\u0026response-content-disposition=attachment%3B+filename%3DTRPs_Links_to_schizophrenia.pdf\u0026Expires=1732739735\u0026Signature=XOUUuKvtRNMr9Es2FypmUS5P7tAQ-6u837VBptzXXHDrZDnYOQ7jaQ0qYfPThyEkI7BJoGkoEW47k8SmueRvvGiqHHJMEkOxJmDnaob3SJx35FWR-tjyAbJLSmxYgKGvKmkiVoiVUISOzSD407EViBtcnJ7u-bM5WMmA2yXe4pTLX69LAxkR9JYzB4sLp9ueWsLRgxeIIama57vXRY6gLcpCulCsarwTcbnFYKBT7M4OHEt5bF~ZoX5l-RVk2IP6RJA53guKIRr7p8tI90onYmby-Qlw124aaTp3j3rZu4J-z7L77~bq1g0EYEgwtZa8sQjXD6o6stwKr~QXQiUlGw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":1389,"name":"Thermoregulation","url":"https://www.academia.edu/Documents/in/Thermoregulation"},{"id":3227,"name":"Schizophrenia","url":"https://www.academia.edu/Documents/in/Schizophrenia"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain"},{"id":93942,"name":"Transient receptor potential channels","url":"https://www.academia.edu/Documents/in/Transient_receptor_potential_channels"},{"id":118582,"name":"Physical sciences","url":"https://www.academia.edu/Documents/in/Physical_sciences"},{"id":157726,"name":"Dopamine Receptors","url":"https://www.academia.edu/Documents/in/Dopamine_Receptors"},{"id":180715,"name":"Body temperature regulation","url":"https://www.academia.edu/Documents/in/Body_temperature_regulation"},{"id":204100,"name":"Capsaicin","url":"https://www.academia.edu/Documents/in/Capsaicin"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":418263,"name":"SYNAPSES","url":"https://www.academia.edu/Documents/in/SYNAPSES"},{"id":1325769,"name":"TRP Channels","url":"https://www.academia.edu/Documents/in/TRP_Channels"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"}],"urls":[{"id":7514461,"url":"http://cat.inist.fr/?aModele=afficheN\u0026cpsidt=18975251"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250633"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250633/Effect_of_subchronic_administration_of_tachykinin_antagonists_on_response_of_guinea_pigs_to_mild_and_severe_stress"><img alt="Research paper thumbnail of Effect of subchronic administration of tachykinin antagonists on response of guinea-pigs to mild and severe stress" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250633/Effect_of_subchronic_administration_of_tachykinin_antagonists_on_response_of_guinea_pigs_to_mild_and_severe_stress">Effect of subchronic administration of tachykinin antagonists on response of guinea-pigs to mild and severe stress</a></div><div class="wp-workCard_item"><span>Regulatory Peptides</span><span>, Jun 7, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The effects of subchronic subcutaneous treatment with tachykinin receptor antagonists over nine d...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The effects of subchronic subcutaneous treatment with tachykinin receptor antagonists over nine days on the repeated mild stress response induced by daily subcutaneous injections and on the severe acute stress induced by morphine withdrawal were investigated in guinea-pigs. The NK(1) receptor antagonist, L733,060, 0.25mg/kg, significantly increased locomotor activity of guinea-pigs compared with animals subjected to repeated injection of the inactive enantiomer, but inhibited Fos-like immunoreactivity (Fos-LI) in the hypothalamus. In animals subjected to the acute severe stress of naltrexone-induced morphine withdrawal, treatment with the NK(1) antagonist, L733,060, produced reductions in Fos-LI in the spinal dorsal horn, whereas those treated with the NK(3) antagonist, SSR146,977, 0.3mg/kg, had reduced Fos-LI in the dorsal horn, adrenal medulla, nucleus accumbens, ventral tegmental area and periaqueductal grey. Those animals treated with both NK(1) and NK(3) antagonists also had reduced Fos-LI in the amygdala and paraventricular nucleus of the thalamus. It was concluded that the NK(1) antagonist reduced the hypothalamic response to mild stress but the NK(3) antagonist was more effective in reducing the severe stress response to morphine withdrawal. Furthermore, combination of NK(1) and NK(3) antagonists was more effective than either antagonist in reducing the Fos-LI response to morphine withdrawal.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250633"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250633"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250633; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250633]").text(description); $(".js-view-count[data-work-id=28250633]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250633; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250633']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250633, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250633]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250633,"title":"Effect of subchronic administration of tachykinin antagonists on response of guinea-pigs to mild and severe stress","translated_title":"","metadata":{"abstract":"The effects of subchronic subcutaneous treatment with tachykinin receptor antagonists over nine days on the repeated mild stress response induced by daily subcutaneous injections and on the severe acute stress induced by morphine withdrawal were investigated in guinea-pigs. The NK(1) receptor antagonist, L733,060, 0.25mg/kg, significantly increased locomotor activity of guinea-pigs compared with animals subjected to repeated injection of the inactive enantiomer, but inhibited Fos-like immunoreactivity (Fos-LI) in the hypothalamus. In animals subjected to the acute severe stress of naltrexone-induced morphine withdrawal, treatment with the NK(1) antagonist, L733,060, produced reductions in Fos-LI in the spinal dorsal horn, whereas those treated with the NK(3) antagonist, SSR146,977, 0.3mg/kg, had reduced Fos-LI in the dorsal horn, adrenal medulla, nucleus accumbens, ventral tegmental area and periaqueductal grey. Those animals treated with both NK(1) and NK(3) antagonists also had reduced Fos-LI in the amygdala and paraventricular nucleus of the thalamus. It was concluded that the NK(1) antagonist reduced the hypothalamic response to mild stress but the NK(3) antagonist was more effective in reducing the severe stress response to morphine withdrawal. Furthermore, combination of NK(1) and NK(3) antagonists was more effective than either antagonist in reducing the Fos-LI response to morphine withdrawal.","publication_date":{"day":7,"month":6,"year":2011,"errors":{}},"publication_name":"Regulatory Peptides"},"translated_abstract":"The effects of subchronic subcutaneous treatment with tachykinin receptor antagonists over nine days on the repeated mild stress response induced by daily subcutaneous injections and on the severe acute stress induced by morphine withdrawal were investigated in guinea-pigs. The NK(1) receptor antagonist, L733,060, 0.25mg/kg, significantly increased locomotor activity of guinea-pigs compared with animals subjected to repeated injection of the inactive enantiomer, but inhibited Fos-like immunoreactivity (Fos-LI) in the hypothalamus. In animals subjected to the acute severe stress of naltrexone-induced morphine withdrawal, treatment with the NK(1) antagonist, L733,060, produced reductions in Fos-LI in the spinal dorsal horn, whereas those treated with the NK(3) antagonist, SSR146,977, 0.3mg/kg, had reduced Fos-LI in the dorsal horn, adrenal medulla, nucleus accumbens, ventral tegmental area and periaqueductal grey. Those animals treated with both NK(1) and NK(3) antagonists also had reduced Fos-LI in the amygdala and paraventricular nucleus of the thalamus. It was concluded that the NK(1) antagonist reduced the hypothalamic response to mild stress but the NK(3) antagonist was more effective in reducing the severe stress response to morphine withdrawal. Furthermore, combination of NK(1) and NK(3) antagonists was more effective than either antagonist in reducing the Fos-LI response to morphine withdrawal.","internal_url":"https://www.academia.edu/28250633/Effect_of_subchronic_administration_of_tachykinin_antagonists_on_response_of_guinea_pigs_to_mild_and_severe_stress","translated_internal_url":"","created_at":"2016-09-04T16:37:00.444-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Effect_of_subchronic_administration_of_tachykinin_antagonists_on_response_of_guinea_pigs_to_mild_and_severe_stress","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":9729,"name":"Stress","url":"https://www.academia.edu/Documents/in/Stress"},{"id":41697,"name":"Nucleus Accumbens","url":"https://www.academia.edu/Documents/in/Nucleus_Accumbens"},{"id":98707,"name":"Stress response","url":"https://www.academia.edu/Documents/in/Stress_response"},{"id":147195,"name":"Central Nervous System","url":"https://www.academia.edu/Documents/in/Central_Nervous_System"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons"},{"id":194429,"name":"Paraventricular Nucleus","url":"https://www.academia.edu/Documents/in/Paraventricular_Nucleus"},{"id":485556,"name":"Guinea Pig","url":"https://www.academia.edu/Documents/in/Guinea_Pig"},{"id":564878,"name":"Body Weight","url":"https://www.academia.edu/Documents/in/Body_Weight"},{"id":564895,"name":"Locomotor Activity","url":"https://www.academia.edu/Documents/in/Locomotor_Activity"},{"id":589853,"name":"Adrenal Gland","url":"https://www.academia.edu/Documents/in/Adrenal_Gland"},{"id":722449,"name":"Physiological Stress Markers","url":"https://www.academia.edu/Documents/in/Physiological_Stress_Markers"},{"id":767927,"name":"Ventral Tegmental Area","url":"https://www.academia.edu/Documents/in/Ventral_Tegmental_Area"},{"id":1834838,"name":"Dorsal Horn","url":"https://www.academia.edu/Documents/in/Dorsal_Horn"},{"id":1880638,"name":"Piperidines","url":"https://www.academia.edu/Documents/in/Piperidines"},{"id":2016105,"name":"Acute stress","url":"https://www.academia.edu/Documents/in/Acute_stress"},{"id":2246318,"name":"Motor activity","url":"https://www.academia.edu/Documents/in/Motor_activity"},{"id":2329699,"name":"Adrenal Medulla","url":"https://www.academia.edu/Documents/in/Adrenal_Medulla"}],"urls":[{"id":7514460,"url":"http://cat.inist.fr/?aModele=afficheN\u0026cpsidt=24199191"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250632"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250632/The_effects_of_haloperidol_treatment_on_the_distribution_of_NK1_receptor_immunoreactive_neurons_in_guinea_pig_brain"><img alt="Research paper thumbnail of The effects of haloperidol treatment on the distribution of NK1 receptor immunoreactive neurons in guinea-pig brain" class="work-thumbnail" src="https://attachments.academia-assets.com/48571680/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250632/The_effects_of_haloperidol_treatment_on_the_distribution_of_NK1_receptor_immunoreactive_neurons_in_guinea_pig_brain">The effects of haloperidol treatment on the distribution of NK1 receptor immunoreactive neurons in guinea-pig brain</a></div><div class="wp-workCard_item"><span>Neuroscience Letters</span><span>, Jul 1, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2e17546f57ff75ae0bd56bd08e405f78" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":48571680,"asset_id":28250632,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/48571680/download_file?st=MTczMjc1Nzk0Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250632"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250632"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250632; 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Since the subjects were medicated the possibility of a treatment effect could not be excluded. Thus, the present study was undertaken to determine the effect of chronic treatment with the antipsychotic drug, haloperidol, on the distribution of NK 1 -IR neurons in the guinea-pig brain. Guinea pigs were treated each day for 21 days with either haloperidol (1 mg/kg) or vehicle and the brains were then processed for immunohistochemistry using an NK 1 receptor-specific polyclonal antibody. NK 1 -IR neurons and fibres were abundant in the forebrain cortex and caudate putamen and more sparsely distributed in a number of other brain regions. The relative density of NK 1 -IR neurons was significantly increased in the forebrain cortex, but not in the caudate putamen in guinea pigs treated with haloperidol. This study has shown that haloperidol causes region-specific changes to the density of NK 1 -IR neurons. Whether these changes are related to the therapeutic effects or to the side effects of haloperidol in individuals with schizophrenia, remains to be determined.","publication_date":{"day":1,"month":7,"year":2005,"errors":{}},"publication_name":"Neuroscience 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�-receptors" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250631/Action_of_Phenylephrine_on_receptors">Action of Phenylephrine on �-receptors</a></div><div class="wp-workCard_item"><span>Immun Cell Biol</span><span>, 1968</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250631"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250631"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250631; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250631]").text(description); $(".js-view-count[data-work-id=28250631]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250631; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250631']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + 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this, workJSON: {"id":28250631,"title":"Action of Phenylephrine on �-receptors","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":1968,"errors":{}},"publication_name":"Immun Cell Biol"},"translated_abstract":null,"internal_url":"https://www.academia.edu/28250631/Action_of_Phenylephrine_on_receptors","translated_internal_url":"","created_at":"2016-09-04T16:37:00.103-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Action_of_Phenylephrine_on_receptors","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris 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class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250630/Increased_plasma_catecholamines_and_locomotor_activity_induced_by_centrally_administered_substance_P_in_guinea_pigs">Increased plasma catecholamines and locomotor activity induced by centrally administered substance P in guinea-pigs</a></div><div class="wp-workCard_item"><span>Neuropharmacology</span><span>, Jul 31, 1988</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The effects on locomotor activity and plasma catecholamines of substance P, 0.5 nmol, injected in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The effects on locomotor activity and plasma catecholamines of substance P, 0.5 nmol, injected into each lateral ventricle (i.c.v.), or 1 nmol, injected into the cisterna magna of conscious guinea-pigs, were investigated. Locomotor activity was measured in cages fitted with an infra-red photocell and detector, and plasma catecholamines, were measured by HPLC with electrochemical detection. Substance P, given intraventricularly or into the cisterna magna, produced increased locomotor activity and a pattern of behavioural activity which mimicked the opiate withdrawal response, found in previous studies in this species. Levels of NA and AD in plasma were also significantly elevated after injection of substance P. These effects of substance P were relatively long-lasting, since they were present up to 1 hr after injection. The results show that the effects of centrally administered substance P in guinea-pigs are similar to those in rats. Furthermore, the results support the suggestion that substance P might be the mediator of the opiate withdrawal response in the central nervous system as has been proposed for the enteric nervous system.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250630"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250630"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250630; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250630]").text(description); $(".js-view-count[data-work-id=28250630]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250630; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250630']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250630, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250630]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250630,"title":"Increased plasma catecholamines and locomotor activity induced by centrally administered substance P in guinea-pigs","translated_title":"","metadata":{"abstract":"The effects on locomotor activity and plasma catecholamines of substance P, 0.5 nmol, injected into each lateral ventricle (i.c.v.), or 1 nmol, injected into the cisterna magna of conscious guinea-pigs, were investigated. Locomotor activity was measured in cages fitted with an infra-red photocell and detector, and plasma catecholamines, were measured by HPLC with electrochemical detection. Substance P, given intraventricularly or into the cisterna magna, produced increased locomotor activity and a pattern of behavioural activity which mimicked the opiate withdrawal response, found in previous studies in this species. Levels of NA and AD in plasma were also significantly elevated after injection of substance P. These effects of substance P were relatively long-lasting, since they were present up to 1 hr after injection. The results show that the effects of centrally administered substance P in guinea-pigs are similar to those in rats. Furthermore, the results support the suggestion that substance P might be the mediator of the opiate withdrawal response in the central nervous system as has been proposed for the enteric nervous system.","publication_date":{"day":31,"month":7,"year":1988,"errors":{}},"publication_name":"Neuropharmacology"},"translated_abstract":"The effects on locomotor activity and plasma catecholamines of substance P, 0.5 nmol, injected into each lateral ventricle (i.c.v.), or 1 nmol, injected into the cisterna magna of conscious guinea-pigs, were investigated. Locomotor activity was measured in cages fitted with an infra-red photocell and detector, and plasma catecholamines, were measured by HPLC with electrochemical detection. Substance P, given intraventricularly or into the cisterna magna, produced increased locomotor activity and a pattern of behavioural activity which mimicked the opiate withdrawal response, found in previous studies in this species. Levels of NA and AD in plasma were also significantly elevated after injection of substance P. These effects of substance P were relatively long-lasting, since they were present up to 1 hr after injection. The results show that the effects of centrally administered substance P in guinea-pigs are similar to those in rats. Furthermore, the results support the suggestion that substance P might be the mediator of the opiate withdrawal response in the central nervous system as has been proposed for the enteric nervous system.","internal_url":"https://www.academia.edu/28250630/Increased_plasma_catecholamines_and_locomotor_activity_induced_by_centrally_administered_substance_P_in_guinea_pigs","translated_internal_url":"","created_at":"2016-09-04T16:36:59.924-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Increased_plasma_catecholamines_and_locomotor_activity_induced_by_centrally_administered_substance_P_in_guinea_pigs","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":7955,"name":"Neuropharmacology","url":"https://www.academia.edu/Documents/in/Neuropharmacology"},{"id":71454,"name":"Epinephrine","url":"https://www.academia.edu/Documents/in/Epinephrine"},{"id":235189,"name":"Norepinephrine","url":"https://www.academia.edu/Documents/in/Norepinephrine"},{"id":485556,"name":"Guinea Pig","url":"https://www.academia.edu/Documents/in/Guinea_Pig"},{"id":564895,"name":"Locomotor Activity","url":"https://www.academia.edu/Documents/in/Locomotor_Activity"},{"id":612551,"name":"Substance P","url":"https://www.academia.edu/Documents/in/Substance_P"},{"id":1222887,"name":"Ratio","url":"https://www.academia.edu/Documents/in/Ratio"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1757315,"name":"Injections","url":"https://www.academia.edu/Documents/in/Injections"},{"id":2246318,"name":"Motor activity","url":"https://www.academia.edu/Documents/in/Motor_activity"}],"urls":[{"id":7514457,"url":"http://cat.inist.fr/?aModele=afficheN\u0026cpsidt=7121675"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250629"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250629/Molecular_Biological_Investigations_into_the_Role_of_the_NMDA_Receptor_in_the_Pathophysiology_of_Schizophrenia"><img alt="Research paper thumbnail of Molecular Biological Investigations into the Role of the NMDA Receptor in the Pathophysiology of Schizophrenia" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250629/Molecular_Biological_Investigations_into_the_Role_of_the_NMDA_Receptor_in_the_Pathophysiology_of_Schizophrenia">Molecular Biological Investigations into the Role of the NMDA Receptor in the Pathophysiology of Schizophrenia</a></div><div class="wp-workCard_item"><span>Aust N Z J Psychiat</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">There is increasing acceptance that schizophrenia is associated with a generalised disorder in co...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">There is increasing acceptance that schizophrenia is associated with a generalised disorder in cortical neurodevelopment. The aim of this paper is to review the evidence that this disorder may be accounted for by abnormalities in mechanisms mediated by the main family of excitatory neuroreceptors in cortical brain systems, the N-methyl-D-aspartate (NMDA) glutamatergic receptors. The neurobiological evidence is presented for an abnormality in cortical development related to synaptic pathology in schizophrenia. The unique functions of the NMDA receptor in information processing are described, especially its role in learning and memory, and in neural plasticity and brain development. It is argued that the cellular and molecular mechanisms which underlie learning and memory also govern normal brain development. Studies examining abnormalities in glutamatergic transmission in schizophrenia are reviewed. There is a substantial literature in support of the possibility that NMDA receptor abnormalities may be involved in the neurodevelopmental predisposition to schizophrenia, as well as in symptom production. Research to determine the role of the NMDA receptor in the pathophysiology of schizophrenia is warranted and now feasible. To be successful, this research will require the application of molecular biology techniques to postmortem brain tissue studies, in addition to traditional histochemical approaches.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250629"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250629"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250629; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250629]").text(description); $(".js-view-count[data-work-id=28250629]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250629; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250629']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250629, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250629]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250629,"title":"Molecular Biological Investigations into the Role of the NMDA Receptor in the Pathophysiology of Schizophrenia","translated_title":"","metadata":{"abstract":"There is increasing acceptance that schizophrenia is associated with a generalised disorder in cortical neurodevelopment. The aim of this paper is to review the evidence that this disorder may be accounted for by abnormalities in mechanisms mediated by the main family of excitatory neuroreceptors in cortical brain systems, the N-methyl-D-aspartate (NMDA) glutamatergic receptors. The neurobiological evidence is presented for an abnormality in cortical development related to synaptic pathology in schizophrenia. The unique functions of the NMDA receptor in information processing are described, especially its role in learning and memory, and in neural plasticity and brain development. It is argued that the cellular and molecular mechanisms which underlie learning and memory also govern normal brain development. Studies examining abnormalities in glutamatergic transmission in schizophrenia are reviewed. There is a substantial literature in support of the possibility that NMDA receptor abnormalities may be involved in the neurodevelopmental predisposition to schizophrenia, as well as in symptom production. Research to determine the role of the NMDA receptor in the pathophysiology of schizophrenia is warranted and now feasible. To be successful, this research will require the application of molecular biology techniques to postmortem brain tissue studies, in addition to traditional histochemical approaches.","publication_date":{"day":null,"month":null,"year":1997,"errors":{}},"publication_name":"Aust N Z J Psychiat"},"translated_abstract":"There is increasing acceptance that schizophrenia is associated with a generalised disorder in cortical neurodevelopment. The aim of this paper is to review the evidence that this disorder may be accounted for by abnormalities in mechanisms mediated by the main family of excitatory neuroreceptors in cortical brain systems, the N-methyl-D-aspartate (NMDA) glutamatergic receptors. The neurobiological evidence is presented for an abnormality in cortical development related to synaptic pathology in schizophrenia. The unique functions of the NMDA receptor in information processing are described, especially its role in learning and memory, and in neural plasticity and brain development. It is argued that the cellular and molecular mechanisms which underlie learning and memory also govern normal brain development. Studies examining abnormalities in glutamatergic transmission in schizophrenia are reviewed. There is a substantial literature in support of the possibility that NMDA receptor abnormalities may be involved in the neurodevelopmental predisposition to schizophrenia, as well as in symptom production. Research to determine the role of the NMDA receptor in the pathophysiology of schizophrenia is warranted and now feasible. To be successful, this research will require the application of molecular biology techniques to postmortem brain tissue studies, in addition to traditional histochemical approaches.","internal_url":"https://www.academia.edu/28250629/Molecular_Biological_Investigations_into_the_Role_of_the_NMDA_Receptor_in_the_Pathophysiology_of_Schizophrenia","translated_internal_url":"","created_at":"2016-09-04T16:36:59.762-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Molecular_Biological_Investigations_into_the_Role_of_the_NMDA_Receptor_in_the_Pathophysiology_of_Schizophrenia","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology"},{"id":3227,"name":"Schizophrenia","url":"https://www.academia.edu/Documents/in/Schizophrenia"},{"id":15572,"name":"Neurodevelopment","url":"https://www.academia.edu/Documents/in/Neurodevelopment"},{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression"},{"id":78467,"name":"Cerebral Cortex","url":"https://www.academia.edu/Documents/in/Cerebral_Cortex"},{"id":176503,"name":"Synaptic Transmission","url":"https://www.academia.edu/Documents/in/Synaptic_Transmission"}],"urls":[{"id":7514456,"url":"http://informahealthcare.com/doi/abs/10.3109/00048679709073795"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250628"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250628/Capsaicin_pretreatment_does_not_inhibit_the_opioid_withdrawal_response_in_guinea_pigs"><img alt="Research paper thumbnail of Capsaicin pretreatment does not inhibit the opioid withdrawal response in guinea-pigs" class="work-thumbnail" src="https://attachments.academia-assets.com/48571678/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250628/Capsaicin_pretreatment_does_not_inhibit_the_opioid_withdrawal_response_in_guinea_pigs">Capsaicin pretreatment does not inhibit the opioid withdrawal response in guinea-pigs</a></div><div class="wp-workCard_item"><span>European Journal of Pharmacology</span><span>, Dec 6, 1988</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b4fa8d4be308d351ab25bcc3808996f4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":48571678,"asset_id":28250628,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/48571678/download_file?st=MTczMjc1Nzk0Myw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250628"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250628"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250628; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250628]").text(description); $(".js-view-count[data-work-id=28250628]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250628; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250628']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250628, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b4fa8d4be308d351ab25bcc3808996f4" } } $('.js-work-strip[data-work-id=28250628]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250628,"title":"Capsaicin pretreatment does not inhibit the opioid withdrawal response in guinea-pigs","translated_title":"","metadata":{"grobid_abstract":"The effects of capsaicin pretreatment on withdrawal responses of guinea-pig isolated ileum to [MetS]enkephalin (ME) and morphine and on the locomotor withdrawal response of guinea-pigs following a single dose of morphine, were investigated. In vitro treatment of ileum with capsaicin, 1.5 ttmol/1 for 1 h, did not significantly affect the response to washout following 2 min contact with ME, 1 ~tmol/l, or the withdrawal response precipitated by naloxone, 1/xmol/1, following 2 min contact with morphine, 1/tmol/1, or the response to naloxone of tolerant-dependent ileum obtained from guinea-pigs treated with a total dose of 690 mg/kg of morphine over 3 days. Pretreatment of guinea-pigs with capsaicin 140 mg/kg subcutaneously (s.c.) over 4 days also did not affect the washout withdrawal response of the ileum to ME. Pretreatment of guinea-pigs with capsaicin did not affect the locomotor withdrawal response precipitated by naloxone hydrochloride 15 mg/kg s.c., 2 h after injection of morphine sulphate 15 mg/kg s.c. It was concluded that primary afferent neurones do not play an essential role in opioid withdrawal responses. Opioid withdrawal; Capsaicin; Morphine; Ileum (guinea-pig); Locomotor activity 0014-2999/88/$03.50","publication_date":{"day":6,"month":12,"year":1988,"errors":{}},"publication_name":"European Journal of Pharmacology","grobid_abstract_attachment_id":48571678},"translated_abstract":null,"internal_url":"https://www.academia.edu/28250628/Capsaicin_pretreatment_does_not_inhibit_the_opioid_withdrawal_response_in_guinea_pigs","translated_internal_url":"","created_at":"2016-09-04T16:36:59.608-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":48571678,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/48571678/thumbnails/1.jpg","file_name":"0014-2999_2888_2990257-920160904-6256-1en59o.pdf","download_url":"https://www.academia.edu/attachments/48571678/download_file?st=MTczMjc1Nzk0Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Capsaicin_pretreatment_does_not_inhibit.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/48571678/0014-2999_2888_2990257-920160904-6256-1en59o-libre.pdf?1473032418=\u0026response-content-disposition=attachment%3B+filename%3DCapsaicin_pretreatment_does_not_inhibit.pdf\u0026Expires=1732739736\u0026Signature=FJhLnocMwfZKTGyAVkbd-aBF-GxcPOrAE4UIwoglhSkTw-XfOSuZPbsOr~NGrGiWpCTGejGJ4Zn1duXr89S6ewQQyabtumFgp~MvyhiAr~6RDuBwjuWpDfj6NREFd~Z0zLi~YsYmng4L8NVJoEYMeeAp3YA4TcKSIRi3vrm4MFkwvx6W2mNZMg24S04dYkICM8trfsJbNBM4QIbDqYLUlef5jD-5ZO1esfj~YS7UNGeCygxer5XNmIIVaxwz5jXfkAlIZOEowruayutilMXVIAYhv1tJN0gQqTloMP8eEhvQj7YdD~keE8o-S-5BMM-iHAw~KtbwvyqG89PKQthxwQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Capsaicin_pretreatment_does_not_inhibit_the_opioid_withdrawal_response_in_guinea_pigs","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[{"id":48571678,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/48571678/thumbnails/1.jpg","file_name":"0014-2999_2888_2990257-920160904-6256-1en59o.pdf","download_url":"https://www.academia.edu/attachments/48571678/download_file?st=MTczMjc1Nzk0Myw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Capsaicin_pretreatment_does_not_inhibit.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/48571678/0014-2999_2888_2990257-920160904-6256-1en59o-libre.pdf?1473032418=\u0026response-content-disposition=attachment%3B+filename%3DCapsaicin_pretreatment_does_not_inhibit.pdf\u0026Expires=1732739736\u0026Signature=FJhLnocMwfZKTGyAVkbd-aBF-GxcPOrAE4UIwoglhSkTw-XfOSuZPbsOr~NGrGiWpCTGejGJ4Zn1duXr89S6ewQQyabtumFgp~MvyhiAr~6RDuBwjuWpDfj6NREFd~Z0zLi~YsYmng4L8NVJoEYMeeAp3YA4TcKSIRi3vrm4MFkwvx6W2mNZMg24S04dYkICM8trfsJbNBM4QIbDqYLUlef5jD-5ZO1esfj~YS7UNGeCygxer5XNmIIVaxwz5jXfkAlIZOEowruayutilMXVIAYhv1tJN0gQqTloMP8eEhvQj7YdD~keE8o-S-5BMM-iHAw~KtbwvyqG89PKQthxwQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":9032,"name":"Interaction","url":"https://www.academia.edu/Documents/in/Interaction"},{"id":59370,"name":"In Vitro","url":"https://www.academia.edu/Documents/in/In_Vitro"},{"id":204100,"name":"Capsaicin","url":"https://www.academia.edu/Documents/in/Capsaicin"},{"id":218374,"name":"Morphine","url":"https://www.academia.edu/Documents/in/Morphine"},{"id":336223,"name":"Digestive System","url":"https://www.academia.edu/Documents/in/Digestive_System"},{"id":556021,"name":"Muscle contraction","url":"https://www.academia.edu/Documents/in/Muscle_contraction"},{"id":783432,"name":"Biological activity","url":"https://www.academia.edu/Documents/in/Biological_activity"},{"id":1901112,"name":"Ileum","url":"https://www.academia.edu/Documents/in/Ileum"},{"id":2246318,"name":"Motor activity","url":"https://www.academia.edu/Documents/in/Motor_activity"}],"urls":[{"id":7514455,"url":"http://cat.inist.fr/?aModele=afficheN\u0026cpsidt=7260123"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250627"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250627/Distribution_of_substance_P_like_immunoreactivity_in_guinea_pig_central_nervous_system"><img alt="Research paper thumbnail of Distribution of substance P-like immunoreactivity in guinea pig central nervous system" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250627/Distribution_of_substance_P_like_immunoreactivity_in_guinea_pig_central_nervous_system">Distribution of substance P-like immunoreactivity in guinea pig central nervous system</a></div><div class="wp-workCard_item"><span>Brain Res Bull</span><span>, 1992</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250627"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250627"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250627; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250627]").text(description); $(".js-view-count[data-work-id=28250627]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250627; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250627']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250627, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250627]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250627,"title":"Distribution of substance P-like immunoreactivity in guinea pig central nervous system","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":1992,"errors":{}},"publication_name":"Brain Res Bull"},"translated_abstract":null,"internal_url":"https://www.academia.edu/28250627/Distribution_of_substance_P_like_immunoreactivity_in_guinea_pig_central_nervous_system","translated_internal_url":"","created_at":"2016-09-04T16:36:59.490-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Distribution_of_substance_P_like_immunoreactivity_in_guinea_pig_central_nervous_system","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250626"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250626/The_role_of_prostaglandins_in_chemically_induced_inflammation"><img alt="Research paper thumbnail of The role of prostaglandins in chemically induced inflammation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250626/The_role_of_prostaglandins_in_chemically_induced_inflammation">The role of prostaglandins in chemically induced inflammation</a></div><div class="wp-workCard_item"><span>British journal of experimental pathology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dye leakage in rats, produced by intracutaneous injections of irritants into the abdominal skin, ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dye leakage in rats, produced by intracutaneous injections of irritants into the abdominal skin, was quantitated using the Evans blue technique of Harada et al. (1971). In control rats and in rats pretreated with indomethacin (an inhibitor of prostaglandin synthesis) concentration-response lines were obtained for 5-hydroxytryptamine, histamine, bradykinin and prostaglandin E1, bradykinin in the presence of prostaglandin E1 (10-6 M), adenosine-5&amp;#39;-triphosphate, compound 48/80, capsaicin and silver nitrate. In rats pretreated with indomethacin the dye leakage responses to histamine, prostaglandin E1, adenosine-5&amp;#39;-triphosphate and silver nitrate were significantly reduced, but no significant changes were observed in the responses to the other irritants. It is suggested that part of the action of histamine, adenosine-5&amp;#39;-triphosphate and prostagland in E1 is produced indirectly by releaseor stimulation of the synthesis of prostaglandins or their precursors. These results might have important implications in the understanding of the inflammatory response.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250626"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250626"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250626; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250626]").text(description); $(".js-view-count[data-work-id=28250626]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250626; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250626']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250626, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250626]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250626,"title":"The role of prostaglandins in chemically induced inflammation","translated_title":"","metadata":{"abstract":"Dye leakage in rats, produced by intracutaneous injections of irritants into the abdominal skin, was quantitated using the Evans blue technique of Harada et al. (1971). In control rats and in rats pretreated with indomethacin (an inhibitor of prostaglandin synthesis) concentration-response lines were obtained for 5-hydroxytryptamine, histamine, bradykinin and prostaglandin E1, bradykinin in the presence of prostaglandin E1 (10-6 M), adenosine-5\u0026amp;#39;-triphosphate, compound 48/80, capsaicin and silver nitrate. In rats pretreated with indomethacin the dye leakage responses to histamine, prostaglandin E1, adenosine-5\u0026amp;#39;-triphosphate and silver nitrate were significantly reduced, but no significant changes were observed in the responses to the other irritants. It is suggested that part of the action of histamine, adenosine-5\u0026amp;#39;-triphosphate and prostagland in E1 is produced indirectly by releaseor stimulation of the synthesis of prostaglandins or their precursors. These results might have important implications in the understanding of the inflammatory response.","publication_name":"British journal of experimental pathology"},"translated_abstract":"Dye leakage in rats, produced by intracutaneous injections of irritants into the abdominal skin, was quantitated using the Evans blue technique of Harada et al. (1971). In control rats and in rats pretreated with indomethacin (an inhibitor of prostaglandin synthesis) concentration-response lines were obtained for 5-hydroxytryptamine, histamine, bradykinin and prostaglandin E1, bradykinin in the presence of prostaglandin E1 (10-6 M), adenosine-5\u0026amp;#39;-triphosphate, compound 48/80, capsaicin and silver nitrate. In rats pretreated with indomethacin the dye leakage responses to histamine, prostaglandin E1, adenosine-5\u0026amp;#39;-triphosphate and silver nitrate were significantly reduced, but no significant changes were observed in the responses to the other irritants. It is suggested that part of the action of histamine, adenosine-5\u0026amp;#39;-triphosphate and prostagland in E1 is produced indirectly by releaseor stimulation of the synthesis of prostaglandins or their precursors. These results might have important implications in the understanding of the inflammatory response.","internal_url":"https://www.academia.edu/28250626/The_role_of_prostaglandins_in_chemically_induced_inflammation","translated_internal_url":"","created_at":"2016-09-04T16:36:59.387-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_role_of_prostaglandins_in_chemically_induced_inflammation","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":663253,"name":"Silver Nitrate","url":"https://www.academia.edu/Documents/in/Silver_Nitrate"},{"id":708670,"name":"Prostaglandins","url":"https://www.academia.edu/Documents/in/Prostaglandins"},{"id":1816594,"name":"Adenosine Triphosphate","url":"https://www.academia.edu/Documents/in/Adenosine_Triphosphate"},{"id":1866509,"name":"Indomethacin","url":"https://www.academia.edu/Documents/in/Indomethacin"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250625"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250625/Mast_cell_degranulation_and_increased_vascular_permeability_induced_by_therapeutic_ultrasound_in_the_rat_ankle_joint"><img alt="Research paper thumbnail of Mast cell degranulation and increased vascular permeability induced by 'therapeutic' ultrasound in the rat ankle joint" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250625/Mast_cell_degranulation_and_increased_vascular_permeability_induced_by_therapeutic_ultrasound_in_the_rat_ankle_joint">Mast cell degranulation and increased vascular permeability induced by 'therapeutic' ultrasound in the rat ankle joint</a></div><div class="wp-workCard_item"><span>British journal of experimental pathology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ultrasound at frequencies between 0.75 and 3.0 MHz is widely used in the treatment of musculoskel...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ultrasound at frequencies between 0.75 and 3.0 MHz is widely used in the treatment of musculoskeletal injuries in human and veterinary patients. The mechanisms by which ultrasound affects clinical recovery are, however, incompletely understood. At present no clear rationale has been evolved to guide the selection and use of all the factors comprising the dosage of ultrasound in treatment designed to encourage tissue healing. In the present study applications of ultrasound considered to be therapeutic caused a small but significant increase in vascular permeability in the hindpaw ankles of rats in vivo which was abolished by pre-treatment of the rats with a combination of a histamine H1-receptor antagonist and a serotonin antagonist. Histological sections from rat ankles showed that ultrasound also caused a significant increase in the number of degranulated mast cells above control values. Since mast cells contain histamine, low concentrations of which have been associated with healing, the finding that ultrasound produces mast cell degranulation and evidence of histamine release provides a new direction for investigation of the mechanism of its therapeutic action, and for determination of appropriate regimens of treatment.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250625"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250625"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250625; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250625]").text(description); $(".js-view-count[data-work-id=28250625]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250625; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250625']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250625, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250625]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250625,"title":"Mast cell degranulation and increased vascular permeability induced by 'therapeutic' ultrasound in the rat ankle joint","translated_title":"","metadata":{"abstract":"Ultrasound at frequencies between 0.75 and 3.0 MHz is widely used in the treatment of musculoskeletal injuries in human and veterinary patients. The mechanisms by which ultrasound affects clinical recovery are, however, incompletely understood. At present no clear rationale has been evolved to guide the selection and use of all the factors comprising the dosage of ultrasound in treatment designed to encourage tissue healing. In the present study applications of ultrasound considered to be therapeutic caused a small but significant increase in vascular permeability in the hindpaw ankles of rats in vivo which was abolished by pre-treatment of the rats with a combination of a histamine H1-receptor antagonist and a serotonin antagonist. Histological sections from rat ankles showed that ultrasound also caused a significant increase in the number of degranulated mast cells above control values. Since mast cells contain histamine, low concentrations of which have been associated with healing, the finding that ultrasound produces mast cell degranulation and evidence of histamine release provides a new direction for investigation of the mechanism of its therapeutic action, and for determination of appropriate regimens of treatment.","publication_name":"British journal of experimental pathology"},"translated_abstract":"Ultrasound at frequencies between 0.75 and 3.0 MHz is widely used in the treatment of musculoskeletal injuries in human and veterinary patients. The mechanisms by which ultrasound affects clinical recovery are, however, incompletely understood. At present no clear rationale has been evolved to guide the selection and use of all the factors comprising the dosage of ultrasound in treatment designed to encourage tissue healing. In the present study applications of ultrasound considered to be therapeutic caused a small but significant increase in vascular permeability in the hindpaw ankles of rats in vivo which was abolished by pre-treatment of the rats with a combination of a histamine H1-receptor antagonist and a serotonin antagonist. Histological sections from rat ankles showed that ultrasound also caused a significant increase in the number of degranulated mast cells above control values. Since mast cells contain histamine, low concentrations of which have been associated with healing, the finding that ultrasound produces mast cell degranulation and evidence of histamine release provides a new direction for investigation of the mechanism of its therapeutic action, and for determination of appropriate regimens of treatment.","internal_url":"https://www.academia.edu/28250625/Mast_cell_degranulation_and_increased_vascular_permeability_induced_by_therapeutic_ultrasound_in_the_rat_ankle_joint","translated_internal_url":"","created_at":"2016-09-04T16:36:59.247-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Mast_cell_degranulation_and_increased_vascular_permeability_induced_by_therapeutic_ultrasound_in_the_rat_ankle_joint","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":15570,"name":"Mast Cells","url":"https://www.academia.edu/Documents/in/Mast_Cells"},{"id":118812,"name":"Ultrasonics","url":"https://www.academia.edu/Documents/in/Ultrasonics"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":670043,"name":"Joints","url":"https://www.academia.edu/Documents/in/Joints"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250624"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250624/The_effects_of_selective_dopamine_D_1_and_D_2_antagonists_on_the_locomotor_response_and_brain_monoamine_changes_induced_by_naloxone_precipitated_morphine_withdrawal_in_guinea_pigs"><img alt="Research paper thumbnail of The effects of selective dopamine D-1 and D-2 antagonists on the locomotor response and brain monoamine changes induced by naloxone-precipitated morphine withdrawal in guinea pigs" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250624/The_effects_of_selective_dopamine_D_1_and_D_2_antagonists_on_the_locomotor_response_and_brain_monoamine_changes_induced_by_naloxone_precipitated_morphine_withdrawal_in_guinea_pigs">The effects of selective dopamine D-1 and D-2 antagonists on the locomotor response and brain monoamine changes induced by naloxone-precipitated morphine withdrawal in guinea pigs</a></div><div class="wp-workCard_item"><span>Progress in clinical and biological research</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250624"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250624"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250624; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250624]").text(description); $(".js-view-count[data-work-id=28250624]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250624; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250624']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250624, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250624]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250624,"title":"The effects of selective dopamine D-1 and D-2 antagonists on the locomotor response and brain monoamine changes induced by naloxone-precipitated morphine withdrawal in guinea pigs","translated_title":"","metadata":{"publication_name":"Progress in clinical and biological research"},"translated_abstract":null,"internal_url":"https://www.academia.edu/28250624/The_effects_of_selective_dopamine_D_1_and_D_2_antagonists_on_the_locomotor_response_and_brain_monoamine_changes_induced_by_naloxone_precipitated_morphine_withdrawal_in_guinea_pigs","translated_internal_url":"","created_at":"2016-09-04T16:36:59.147-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_effects_of_selective_dopamine_D_1_and_D_2_antagonists_on_the_locomotor_response_and_brain_monoamine_changes_induced_by_naloxone_precipitated_morphine_withdrawal_in_guinea_pigs","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":51566,"name":"Dopamine","url":"https://www.academia.edu/Documents/in/Dopamine"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain"},{"id":157726,"name":"Dopamine Receptors","url":"https://www.academia.edu/Documents/in/Dopamine_Receptors"},{"id":218374,"name":"Morphine","url":"https://www.academia.edu/Documents/in/Morphine"},{"id":1128472,"name":"Naloxone","url":"https://www.academia.edu/Documents/in/Naloxone"},{"id":2246318,"name":"Motor activity","url":"https://www.academia.edu/Documents/in/Motor_activity"},{"id":2410525,"name":"Sulpiride","url":"https://www.academia.edu/Documents/in/Sulpiride"},{"id":2410542,"name":"Dopamine antagonists","url":"https://www.academia.edu/Documents/in/Dopamine_antagonists"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250623"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250623/The_acute_effects_of_capsaicin_on_the_cardiovascular_system"><img alt="Research paper thumbnail of The acute effects of capsaicin on the cardiovascular system" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250623/The_acute_effects_of_capsaicin_on_the_cardiovascular_system">The acute effects of capsaicin on the cardiovascular system</a></div><div class="wp-workCard_item"><span>Acta Physiologica Hungarica</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Arterial blood pressure and heart rate were recorded from male Wistar rats anaesthetized with ure...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Arterial blood pressure and heart rate were recorded from male Wistar rats anaesthetized with urethane. Intravenous injection of capsaicin, 1 microgram, produced a reproducible triphasic effect on blood pressure, comprising an initial fall in blood pressure and heart rate, followed by a transient and then a sustained pressor response. The depressor response and bradycardia were abolished by vagal section. The transient pressor response was altered in shape by hexamethonium. Slow intravenous infusion of capsaicin, 50 micrograms over 12 min, produced only a sustained pressor response accompanied by tachycardia, which was resistant to hexamethonium but abolished by morphine and pithing. Responses to both 1 microgram injection and 50 micrograms infusion of capsaicin were unaffected by the SP antagonist, spantide, but were abolished by capsaicin pretreatment of the rats. Capsaicin induces complex effects on the cardiovascular system, the nature of which varies with the dose and speed of administration.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250623"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250623"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250623; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250623]").text(description); $(".js-view-count[data-work-id=28250623]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250623; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250623']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250623, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250623]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250623,"title":"The acute effects of capsaicin on the cardiovascular system","translated_title":"","metadata":{"abstract":"Arterial blood pressure and heart rate were recorded from male Wistar rats anaesthetized with urethane. Intravenous injection of capsaicin, 1 microgram, produced a reproducible triphasic effect on blood pressure, comprising an initial fall in blood pressure and heart rate, followed by a transient and then a sustained pressor response. The depressor response and bradycardia were abolished by vagal section. The transient pressor response was altered in shape by hexamethonium. Slow intravenous infusion of capsaicin, 50 micrograms over 12 min, produced only a sustained pressor response accompanied by tachycardia, which was resistant to hexamethonium but abolished by morphine and pithing. Responses to both 1 microgram injection and 50 micrograms infusion of capsaicin were unaffected by the SP antagonist, spantide, but were abolished by capsaicin pretreatment of the rats. Capsaicin induces complex effects on the cardiovascular system, the nature of which varies with the dose and speed of administration.","publication_name":"Acta Physiologica Hungarica"},"translated_abstract":"Arterial blood pressure and heart rate were recorded from male Wistar rats anaesthetized with urethane. Intravenous injection of capsaicin, 1 microgram, produced a reproducible triphasic effect on blood pressure, comprising an initial fall in blood pressure and heart rate, followed by a transient and then a sustained pressor response. The depressor response and bradycardia were abolished by vagal section. The transient pressor response was altered in shape by hexamethonium. Slow intravenous infusion of capsaicin, 50 micrograms over 12 min, produced only a sustained pressor response accompanied by tachycardia, which was resistant to hexamethonium but abolished by morphine and pithing. Responses to both 1 microgram injection and 50 micrograms infusion of capsaicin were unaffected by the SP antagonist, spantide, but were abolished by capsaicin pretreatment of the rats. Capsaicin induces complex effects on the cardiovascular system, the nature of which varies with the dose and speed of administration.","internal_url":"https://www.academia.edu/28250623/The_acute_effects_of_capsaicin_on_the_cardiovascular_system","translated_internal_url":"","created_at":"2016-09-04T16:36:59.030-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_acute_effects_of_capsaicin_on_the_cardiovascular_system","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure"},{"id":131298,"name":"Heart rate","url":"https://www.academia.edu/Documents/in/Heart_rate"},{"id":204100,"name":"Capsaicin","url":"https://www.academia.edu/Documents/in/Capsaicin"},{"id":218374,"name":"Morphine","url":"https://www.academia.edu/Documents/in/Morphine"},{"id":230879,"name":"Denervation","url":"https://www.academia.edu/Documents/in/Denervation"},{"id":312834,"name":"Cardiovascular system","url":"https://www.academia.edu/Documents/in/Cardiovascular_system"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":612551,"name":"Substance P","url":"https://www.academia.edu/Documents/in/Substance_P"},{"id":1748602,"name":"Vagus Nerve","url":"https://www.academia.edu/Documents/in/Vagus_Nerve"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250622"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250622/Acute_effects_of_morphine_on_Substance_P_concentrations_in_microdissected_regions_of_guinea_pig_brain"><img alt="Research paper thumbnail of Acute effects of morphine on Substance P concentrations in microdissected regions of guinea-pig brain" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250622/Acute_effects_of_morphine_on_Substance_P_concentrations_in_microdissected_regions_of_guinea_pig_brain">Acute effects of morphine on Substance P concentrations in microdissected regions of guinea-pig brain</a></div><div class="wp-workCard_item"><span>Behavioural pharmacology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The present study investigated the effects of acute morphine treatment and of naloxone-induced mo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The present study investigated the effects of acute morphine treatment and of naloxone-induced morphine withdrawal on Substance P (SP) concentrations in microdissected regions of the guinea-pig brain. Guinea-pigs, which were treated with a single dose of morphine sulphate (15mg/kg s.c.), received naloxone hydrochloride (15mg/kg s.c.) after 2h. Control animals received injections of saline, saline and naloxone, or morphine and saline. Locomotor and behavioural activities were measured throughout the experiments. Animals were killed 0.5h after naloxone administration, brains were removed and SP-like immunoreactivity (SP-LI) was measured in microdissected regions using radioimmunoassay. Morphine significantly increased the concentration of SP-LI in the central nucleus of the amygdala, but reduced SP-LI overall in the mesencephalon. Guinea-pigs pretreated with morphine and then given naloxone to precipitate withdrawal showed no change in SP-LI concentrations in any brain region, compare...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250622"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250622"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250622; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250622]").text(description); $(".js-view-count[data-work-id=28250622]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250622; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250622']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250622, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250622]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250622,"title":"Acute effects of morphine on Substance P concentrations in microdissected regions of guinea-pig brain","translated_title":"","metadata":{"abstract":"The present study investigated the effects of acute morphine treatment and of naloxone-induced morphine withdrawal on Substance P (SP) concentrations in microdissected regions of the guinea-pig brain. 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Guinea-pigs pretreated with morphine and then given naloxone to precipitate withdrawal showed no change in SP-LI concentrations in any brain region, compare...","publication_name":"Behavioural pharmacology"},"translated_abstract":"The present study investigated the effects of acute morphine treatment and of naloxone-induced morphine withdrawal on Substance P (SP) concentrations in microdissected regions of the guinea-pig brain. Guinea-pigs, which were treated with a single dose of morphine sulphate (15mg/kg s.c.), received naloxone hydrochloride (15mg/kg s.c.) after 2h. Control animals received injections of saline, saline and naloxone, or morphine and saline. Locomotor and behavioural activities were measured throughout the experiments. Animals were killed 0.5h after naloxone administration, brains were removed and SP-like immunoreactivity (SP-LI) was measured in microdissected regions using radioimmunoassay. Morphine significantly increased the concentration of SP-LI in the central nucleus of the amygdala, but reduced SP-LI overall in the mesencephalon. Guinea-pigs pretreated with morphine and then given naloxone to precipitate withdrawal showed no change in SP-LI concentrations in any brain region, compare...","internal_url":"https://www.academia.edu/28250622/Acute_effects_of_morphine_on_Substance_P_concentrations_in_microdissected_regions_of_guinea_pig_brain","translated_internal_url":"","created_at":"2016-09-04T16:36:58.917-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":52887487,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Acute_effects_of_morphine_on_Substance_P_concentrations_in_microdissected_regions_of_guinea_pig_brain","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":52887487,"first_name":"Loris","middle_initials":null,"last_name":"Chahl","page_name":"LorisChahl","domain_name":"independent","created_at":"2016-09-02T23:33:17.365-07:00","display_name":"Loris Chahl","url":"https://independent.academia.edu/LorisChahl"},"attachments":[],"research_interests":[{"id":1115963,"name":"Behavioural Pharmacology","url":"https://www.academia.edu/Documents/in/Behavioural_Pharmacology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250621"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250621/The_Effect_of_Substance_P_Antiserum_on_Responses_of_Guinea_Pig_Isolated_Ileum_to_Substance_P_and_Acetylcholine"><img alt="Research paper thumbnail of The Effect of Substance P Antiserum on Responses of Guinea-Pig Isolated Ileum to Substance P and Acetylcholine" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250621/The_Effect_of_Substance_P_Antiserum_on_Responses_of_Guinea_Pig_Isolated_Ileum_to_Substance_P_and_Acetylcholine">The Effect of Substance P Antiserum on Responses of Guinea-Pig Isolated Ileum to Substance P and Acetylcholine</a></div><div class="wp-workCard_item"><span>Substance P and Neurokinins</span><span>, 1987</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250621"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250621"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250621; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="28250620"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/28250620/Effects_of_neonatal_treatment_with_the_TRPV1_agonist_capsaicin_on_adult_rat_brain_and_behaviour"><img alt="Research paper thumbnail of Effects of neonatal treatment with the TRPV1 agonist, capsaicin, on adult rat brain and behaviour" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/28250620/Effects_of_neonatal_treatment_with_the_TRPV1_agonist_capsaicin_on_adult_rat_brain_and_behaviour">Effects of neonatal treatment with the TRPV1 agonist, capsaicin, on adult rat brain and behaviour</a></div><div class="wp-workCard_item"><span>Behavioural brain research</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Treatment of neonatal rats with the transient receptor potential vanilloid 1 (TRPV1) channel agon...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Treatment of neonatal rats with the transient receptor potential vanilloid 1 (TRPV1) channel agonist, capsaicin, produces life-long loss of sensory neurons expressing TRPV1 channels. Previously it was shown that rats treated on day 2 of life with capsaicin had behavioural hyperactivity in a novel environment at 5-7 weeks of age and brain changes reminiscent of those found in subjects with schizophrenia. The objective of the present study was to investigate brain and behavioural responses of adult rats treated as neonates with capsaicin. It was found that the brain changes found at 5-7 weeks in rats treated as neonates with capsaicin persisted into adulthood (12 weeks) but were less in older rats (16-18 weeks). Increased prepulse inhibition (PPI) of acoustic startle was found in these rats at 8 and 12 weeks of age rather than the deficit commonly found in animal models of schizophrenia. Subjects with schizophrenia also have reduced flare responses to niacin and methylnicotinate propo...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="28250620"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="28250620"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 28250620; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=28250620]").text(description); $(".js-view-count[data-work-id=28250620]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 28250620; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='28250620']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 28250620, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=28250620]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":28250620,"title":"Effects of neonatal treatment with the TRPV1 agonist, capsaicin, on adult rat brain and behaviour","translated_title":"","metadata":{"abstract":"Treatment of neonatal rats with the transient receptor potential vanilloid 1 (TRPV1) channel agonist, capsaicin, produces life-long loss of sensory neurons expressing TRPV1 channels. 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