Developability Assessment | Twist Bioscience

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<div id="main"> <div class="row-offcanvas row-offcanvas-left clearfix"> <main class="main-content col" id="content" role="main"> <section class="section"> <a id="main-content" tabindex="-1"></a> <div data-drupal-messages-fallback class="hidden"></div> <div id="block-twist-barrio-content" class="block block-system block-system-main-block"> <div class="content"> <article data-history-node-id="36546" about="/product/antibody-discovery/characterization/developability" class="node node--type-landing-page-v2 node--view-mode-full" data-type="promotion" data-product="Biopharma"> <div class="node__content"> <div class="field field--name-field-page-banner field--type-entity-reference-revisions field--label-hidden field__item"> <style> @media (min-width: 1200px) { .banner.paragraph--type--banner { background-image: url(/sites/default/files/2024-05/%E2%89%A51440px.png); background-size: cover; } } @media (min-width: 768px) and (max-width: 1199px) { .banner.paragraph--type--banner { background-image: url(/sites/default/files/2024-05/%E2%89%A51440px.png); background-size: cover; } } @media (max-width: 767px) { .banner.paragraph--type--banner { background-image: url(/sites/default/files/2024-05/%E2%89%A51440px.png); background-size: cover; } } </style> <div class="banner paragraph paragraph--type--banner paragraph--view-mode--default reverse"> <div class="container"> <div class="banner__content"> <div class="field field--name-field-banner-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <section class="section-background text-start" style="background-color:transparent;"> <div class="clearfix component-paragraph paragraph paragraph--type--section paragraph--view-mode--default"> <div class="section-wrapper container"> <div class="row"> <div class="paragraph col-lg-8 col-sm-8 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h1>Developability Assessment</h1></div> </div> </div> <div class="paragraph col-lg-4 col-sm-4 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><p>Identify Your Most Stable and Manufacturable Leads</p> <p><a class="btn btn-secondary btn-xl twist-anchor-link" href="#mktoForm_1108">Contact Us</a></p> </div> </div> </div> </div> </div> </div> </section> </div> </div> </div> </div> </div> </div> <div class="field field--name-field-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <section class="section-background section-no-pad" style="background-color:transparent;"> <div class="container-fluid"> <div class="row paragraph paragraph--type--section paragraph--view-mode--default" > <div class="no-custom-show-more paragraph paragraph--type--section-tabs paragraph--view-mode--default scroll" data-style="scroll"> <div class="field field--name-field-cp-title field--type-string field--label-hidden field__item" id="overview">Overview</div> <div class="field field--name-field-cp-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="desktop-layer"> <div class="container"> <div class="virtual-wrapper row"> <div class="virtual-region-left col-md-12"> <div class="paragraph paragraph--type--layout paragraph--view-mode--default col-lg-8 col-sm-8 col-12"> <div class="row "> <div class="clearfix component-paragraph paragraph paragraph--type--component-text paragraph--view-mode--default"> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><h3 class="text-align-center">Antibody Development with the End in Mind</h3> <p>Developability parameters – such as solubility, stability, and aggregation – are a core component to define and advance a promising antibody lead.<br> <br> At Twist Biopharma Solutions, we offer a comprehensive developability assessment package to complement our antibody production and broader antibody characterization offerings. Our flexible suite of chromatography, spectroscopy, and fluorimetry instruments provide valuable data to help you confidently select the most robust antibody candidates for downstream development and formulation.</p> <p><img alt="graph" class="twist-lightbox" data-entity-type="file" data-entity-uuid="1183546d-c2bc-44c8-ba76-8f0a1d389c6c" id src="/sites/default/files/inline-images/Screenshot%202024-08-19%20at%206.42.18%E2%80%AFPM%201%20%281%29.png" title width="1644" height="764" data-mfp-src="/sites/default/files/inline-images/Screenshot%202024-08-19%20at%206.42.18%E2%80%AFPM%201%20%281%29.png" loading="lazy"></p></div> </div> </div> </div> <div class="paragraph paragraph--type--layout paragraph--view-mode--default col-lg-9 col-sm-9 col-12"> <div class="row "> <div class="paragraph paragraph--type--text-new-design paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-tnd-text field--type-text-long field--label-hidden field__item"><h3 class="text-align-center">Flexible Developability Assessment Packages</h3></div> </div> <div class="paragraph col-lg-4 col-sm-4 col-12 paragraph--type--icon-with-text paragraph--view-mode--default image-top background" style="background-color:transparent"> <div class="inner-wrapper gray-box-border"> <div class="field field--name-field-icon field--type-image field--label-hidden field__item"> <img src="/sites/default/files/2024-11/uniformity.png" width="128" height="128" alt="" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><p class="text-align-center"><strong>Size Exclusion Chromatography (SEC)</strong></p></div> </div> </div> <div class="paragraph col-lg-4 col-sm-4 col-12 paragraph--type--icon-with-text paragraph--view-mode--default image-top background" style="background-color:transparent"> <div class="inner-wrapper gray-box-border"> <div class="field field--name-field-icon field--type-image field--label-hidden field__item"> <img src="/sites/default/files/2024-11/enlarge.png" width="128" height="128" alt="" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><p class="text-align-center"><strong>Cross-Interaction Chromatography (CIC)</strong></p></div> </div> </div> <div class="paragraph col-lg-4 col-sm-4 col-12 paragraph--type--icon-with-text paragraph--view-mode--default image-top background" style="background-color:transparent"> <div class="inner-wrapper gray-box-border"> <div class="field field--name-field-icon field--type-image field--label-hidden field__item"> <img src="/sites/default/files/2024-11/NGS%20Icon%2010.png" width="128" height="128" alt="" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><p class="text-align-center"><strong>Hydrophobic Interaction Chromatography (HIC)</strong></p></div> </div> </div> <div class="paragraph col-lg-6 col-sm-6 col-12 paragraph--type--icon-with-text paragraph--view-mode--default image-top background" style="background-color:transparent"> <div class="inner-wrapper gray-box-border"> <div class="field field--name-field-icon field--type-image field--label-hidden field__item"> <img src="/sites/default/files/2024-11/movement.png" width="128" height="128" alt="" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><p class="text-align-center"><strong>Affinity-Capture Self-Interaction<br> Nanoparticle Spectroscopy (AC-SINS)</strong></p></div> </div> </div> <div class="paragraph col-lg-6 col-sm-6 col-12 paragraph--type--icon-with-text paragraph--view-mode--default image-top background" style="background-color:transparent"> <div class="inner-wrapper gray-box-border"> <div class="field field--name-field-icon field--type-image field--label-hidden field__item"> <img src="/sites/default/files/2024-11/antibody-discovery%20%281%29.png" width="128" height="128" alt="" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><p class="text-align-center"><strong>Thermal Stability (Tm, Tonset, Tagg, rH, Tsize)</strong></p></div> </div> </div> </div> </div> </div> <div class="clearfix"></div> </div> </div> </div> <div class="mobile-layer"> <div class="paragraph paragraph--type--layout paragraph--view-mode--default col-lg-8 col-sm-8 col-12"> <div class="row "> <div class="clearfix component-paragraph paragraph paragraph--type--component-text paragraph--view-mode--default"> <div class="custom-show-more clearfix text-formatted field field--name-field-cp-text-text field--type-text-with-summary field--label-hidden field__item"><h3 class="text-align-center">Antibody Development with the End in Mind</h3> <p>Developability parameters – such as solubility, stability, and aggregation – are a core component to define and advance a promising antibody lead.<br> <br> At Twist Biopharma Solutions, we offer a comprehensive developability assessment package to complement our antibody production and broader antibody characterization offerings. Our flexible suite of chromatography, spectroscopy, and fluorimetry instruments provide valuable data to help you confidently select the most robust antibody candidates for downstream development and formulation.</p> <p><img alt="graph" class="twist-lightbox" data-entity-type="file" data-entity-uuid="1183546d-c2bc-44c8-ba76-8f0a1d389c6c" id src="/sites/default/files/inline-images/Screenshot%202024-08-19%20at%206.42.18%E2%80%AFPM%201%20%281%29.png" title width="1644" height="764" data-mfp-src="/sites/default/files/inline-images/Screenshot%202024-08-19%20at%206.42.18%E2%80%AFPM%201%20%281%29.png" loading="lazy"></p></div> </div> </div> </div> <div class="paragraph paragraph--type--layout paragraph--view-mode--default col-lg-9 col-sm-9 col-12"> <div class="row "> <div class="paragraph paragraph--type--text-new-design paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-tnd-text field--type-text-long field--label-hidden field__item"><h3 class="text-align-center">Flexible Developability Assessment Packages</h3></div> </div> <div class="paragraph col-lg-4 col-sm-4 col-12 paragraph--type--icon-with-text paragraph--view-mode--default image-top background" style="background-color:transparent"> <div class="inner-wrapper gray-box-border"> <div class="field field--name-field-icon field--type-image field--label-hidden field__item"> <img src="/sites/default/files/2024-11/uniformity.png" width="128" height="128" alt="" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><p class="text-align-center"><strong>Size Exclusion Chromatography (SEC)</strong></p></div> </div> </div> <div class="paragraph col-lg-4 col-sm-4 col-12 paragraph--type--icon-with-text paragraph--view-mode--default image-top background" style="background-color:transparent"> <div class="inner-wrapper gray-box-border"> <div class="field field--name-field-icon field--type-image field--label-hidden field__item"> <img src="/sites/default/files/2024-11/enlarge.png" width="128" height="128" alt="" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><p class="text-align-center"><strong>Cross-Interaction Chromatography (CIC)</strong></p></div> </div> </div> <div class="paragraph col-lg-4 col-sm-4 col-12 paragraph--type--icon-with-text paragraph--view-mode--default image-top background" style="background-color:transparent"> <div class="inner-wrapper gray-box-border"> <div class="field field--name-field-icon field--type-image field--label-hidden field__item"> <img src="/sites/default/files/2024-11/NGS%20Icon%2010.png" width="128" height="128" alt="" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><p class="text-align-center"><strong>Hydrophobic Interaction Chromatography (HIC)</strong></p></div> </div> </div> <div class="paragraph col-lg-6 col-sm-6 col-12 paragraph--type--icon-with-text paragraph--view-mode--default image-top background" style="background-color:transparent"> <div class="inner-wrapper gray-box-border"> <div class="field field--name-field-icon field--type-image field--label-hidden field__item"> <img src="/sites/default/files/2024-11/movement.png" width="128" height="128" alt="" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><p class="text-align-center"><strong>Affinity-Capture Self-Interaction<br> Nanoparticle Spectroscopy (AC-SINS)</strong></p></div> </div> </div> <div class="paragraph col-lg-6 col-sm-6 col-12 paragraph--type--icon-with-text paragraph--view-mode--default image-top background" style="background-color:transparent"> <div class="inner-wrapper gray-box-border"> <div class="field field--name-field-icon field--type-image field--label-hidden field__item"> <img src="/sites/default/files/2024-11/antibody-discovery%20%281%29.png" width="128" height="128" alt="" loading="lazy" typeof="foaf:Image" /> </div> <div class="clearfix text-formatted field field--name-field-html field--type-text-long field--label-hidden field__item"><p class="text-align-center"><strong>Thermal Stability (Tm, Tonset, Tagg, rH, Tsize)</strong></p></div> </div> </div> </div> </div> </div> </div> </div> <div class="no-custom-show-more paragraph paragraph--type--section-tabs paragraph--view-mode--default scroll" data-style="scroll"> <div class="field field--name-field-cp-title field--type-string field--label-hidden field__item" id="data">DATA</div> <div class="field field--name-field-cp-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="desktop-layer"> <div class="container"> <div class="virtual-wrapper row"> <div class="virtual-region-left col-md-12"> <div class="paragraph paragraph--type--layout paragraph--view-mode--default col-lg-8 col-sm-8 col-12"> <div class="row "> <div class="paragraph paragraph--type--text-new-design paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-tnd-text field--type-text-long field--label-hidden field__item"><h3 class="text-align-center">Reference Standards for Developability Assessment</h3> <p><img alt="data" class="twist-lightbox" data-entity-type="file" data-entity-uuid="5623f490-13db-455a-bac0-2afec3d1cea4" id src="/sites/default/files/inline-images/Screenshot%202024-08-06%20at%208.49.27%E2%80%AFPM%201%20%281%29.png" title width="2292" height="540" data-mfp-src="/sites/default/files/inline-images/Screenshot%202024-08-06%20at%208.49.27%E2%80%AFPM%201%20%281%29.png" loading="lazy"></p> <p>The figure above shows the performance of 12 reference standards using four of our developability assays. Each assay provides critical data on the interaction and behavior of antibody candidates, assisting in selecting the most promising leads for further development. The colored zones in each graph indicate different thresholds of acceptability for downstream development.</p> </div> </div> </div> </div> </div> <div class="clearfix"></div> </div> </div> </div> <div class="mobile-layer"> <div class="paragraph paragraph--type--layout paragraph--view-mode--default col-lg-8 col-sm-8 col-12"> <div class="row "> <div class="paragraph paragraph--type--text-new-design paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-tnd-text field--type-text-long field--label-hidden field__item"><h3 class="text-align-center">Reference Standards for Developability Assessment</h3> <p><img alt="data" class="twist-lightbox" data-entity-type="file" data-entity-uuid="5623f490-13db-455a-bac0-2afec3d1cea4" id src="/sites/default/files/inline-images/Screenshot%202024-08-06%20at%208.49.27%E2%80%AFPM%201%20%281%29.png" title width="2292" height="540" data-mfp-src="/sites/default/files/inline-images/Screenshot%202024-08-06%20at%208.49.27%E2%80%AFPM%201%20%281%29.png" loading="lazy"></p> <p>The figure above shows the performance of 12 reference standards using four of our developability assays. Each assay provides critical data on the interaction and behavior of antibody candidates, assisting in selecting the most promising leads for further development. The colored zones in each graph indicate different thresholds of acceptability for downstream development.</p> </div> </div> </div> </div> </div> </div> </div> <div class="no-custom-show-more paragraph paragraph--type--section-tabs paragraph--view-mode--default scroll" data-style="scroll"> <div class="field field--name-field-cp-title field--type-string field--label-hidden field__item" id="technical-resources">TECHNICAL RESOURCES</div> <div class="field field--name-field-cp-paragraphs field--type-entity-reference-revisions field--label-hidden field__items"> <div class="desktop-layer"> <div class="container"> <div class="virtual-wrapper row"> <div class="clearfix"></div> </div> </div> <div class="virtual-region-bottom_full"> <section class="section-background" style="background-color:transparent;"> <div class="clearfix component-paragraph paragraph paragraph--type--section paragraph--view-mode--default"> <div class="section-wrapper container"> <div class="row"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile mb-5 " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h2 class="text-align-center">Technical Resources</h2> </div> </div> </div> <div class="paragraph paragraph--type--layout paragraph--view-mode--default col-lg-12 col-sm-12 col-12"> <div class="row "> <div class="paragraph col-lg-4 col-sm-4 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile card-explore gray-box-border mx-2 " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h4>High-Throughput Antibody Characterization Services</h4> <div class="tag-wrapper"><span class="type sheet">Case Studies</span><a class="category" href="#" tabindex="-1">Biopharma</a></div> <p><a href="https://www.twistbioscience.com/sites/default/files/resources/2019-04/Poster_BioPharma_PEGS_TAO%202019_03Apr19_FINAL.pdf">Download the PDF</a></p> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> </div> <div class="mobile-layer"> <section class="section-background" style="background-color:transparent;"> <div class="clearfix component-paragraph paragraph paragraph--type--section paragraph--view-mode--default"> <div class="section-wrapper container"> <div class="row"> <div class="paragraph col-lg-12 col-sm-12 col-12 paragraph--type--text paragraph--view-mode--default"> <div class="tile mb-5 " style="background-color: transparent;"> <div class="clearfix text-formatted field field--name-field-paragraph-text field--type-text-long field--label-hidden field__item"><h2 class="text-align-center">Technical Resources</h2> </div> </div> </div> <div class="paragraph paragraph--type--layout paragraph--view-mode--default col-lg-12 col-sm-12 col-12"> <div class="row "> 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