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Advancements in Immunotherapy for Lymphoma: A Focus on Non-Hodgkin’s Lymphoma – Cancer Science
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id="primary"> <main class="site-main" id="main"> <article id="post-236" class="post-236 post type-post status-publish format-standard has-post-thumbnail hentry category-non-hodgkins-lymphoma tag-b-cell-malignancies tag-biomarkers tag-car-t-cell-therapy tag-cytokine-release-syndrome tag-diffuse-large-b-cell-lymphoma tag-immunotherapy tag-neurotoxicity tag-non-hodgkins-lymphoma tag-refractory-lymphoma tag-relapsed-lymphoma" itemtype="https://schema.org/CreativeWork" itemscope> <div class="inside-article"> <div class="featured-image page-header-image-single "> <img width="800" height="419" src="https://cancerscience.net/archive/wp-content/uploads/2024/10/banner-12-01.jpg" class="attachment-full size-full" alt="" itemprop="image" decoding="async" fetchpriority="high" srcset="https://cancerscience.net/archive/wp-content/uploads/2024/10/banner-12-01.jpg 800w, https://cancerscience.net/archive/wp-content/uploads/2024/10/banner-12-01-300x157.jpg 300w, https://cancerscience.net/archive/wp-content/uploads/2024/10/banner-12-01-768x402.jpg 768w" sizes="(max-width: 800px) 100vw, 800px" /> </div> <header class="entry-header"> <h1 class="entry-title" itemprop="headline">Advancements in Immunotherapy for Lymphoma: A Focus on Non-Hodgkin’s Lymphoma</h1> <div class="entry-meta"> <span class="posted-on"><time class="entry-date published" datetime="2024-10-16T15:55:48+05:30" itemprop="datePublished">October 16, 2024</time></span> <span class="byline">by <span class="author vcard" itemprop="author" itemtype="https://schema.org/Person" itemscope><a class="url fn n" href="https://cancerscience.net/archive/author/cancerscience/" title="View all posts by cancerscience" rel="author" itemprop="url"><span class="author-name" itemprop="name">cancerscience</span></a></span></span> </div> </header> <div class="entry-content" itemprop="text"> <h3><b>Introduction</b></h3> <p><span style="font-weight: 400;">NHL is a complex category of diseases that, grouped under a common title, are considered a type of blood cancer and can be subdivided into hundreds of variants that are quite different from one another. In the past few decades, NHL has been highly advanced, especially with the development of immunotherapy. It has provided a new lease on life as it were to many people, or in medical terms, has significantly altered the outlook or prognosis for many patients where orthodox medicine has failed. Immunotherapy is a form of treatment that uses the patient’s immune system to identify and eradicate cancer cells; in NHL, immunotherapy has been exceptionally revolutionary. In this article, the author goes further into explaining immunotherapy in NHL, more so the CAR T cell therapy, biomarkers, and other surfaces in managing the complexities of the resistant forms of NHL</span><span style="font-weight: 400;">.</span></p> <h3><b>The Role of CAR T-Cell Therapy in NHL</b></h3> <p><span style="font-weight: 400;">Among the current principal advances in the treatment of NHL is CAR T-cell therapy. This is called chimeric antigen receptor T-cell or CAR T-cell therapy: a new method of treatment that entails re-programming a patient’s T cells to attack cancerous cells directly. CAR T-cell therapy, especially in B-cell neoplasia, has been successful on a large scale. Specifically, therapies targeting CD19+ CAR T-cells have become highly effective in the treatment of a variety of NHL subtypes, among which are DLBCL, follicular, and mantle cell lymphoma.</span></p> <p><span style="font-weight: 400;">The principle of treating CAR T-cells is based on guiding the patient’s modified T cells to recognize and kill those cancer cells displaying the CD19 antigen, which is found on the surface of a range of B-cell lymphomas. People who have not responded to standard-of-care therapies, including chemotherapy and stem cell transplantation, have slightly had remission survival rates after they underwent CAR T-cell therapy. The overall response rates (ORRs) have therefore been good, and many patients have, for example, achieved complete remission. Nevertheless, as with the vast majority of treatments, it is not free of difficulties, or more specifically, related to the challenge of CRS and neurotoxicity.</span></p> <h3><b>Cytokine Release Syndrome: A Manageable Complication</b></h3> <p><span style="font-weight: 400;">Cytokine release syndrome is one of the most frequent and, at the same time, severe side effects linked to CAR T-cell therapy. It occurs from the discharge of cytokines in the bloodstream, and the increase may result in systemic inflammation as well as the failure of multiple organs if the release is not regulated. Nevertheless, CRS is rather tolerable and can effectively be addressed if intervened early enough. The identification of predictive biomarkers has played an important role in the matter; clinicians have been able to prevent the development of CRS, thus the prescription of tocilizumab, an anti-IL-6 receptor antibody.</span></p> <p><span style="font-weight: 400;">Furthermore, it was established that the severity of CRS can be linked to specific clinical biomarkers, as well as the level of cytokines in the IL-6 and IFN-γ groups. The tracking of these should enable healthcare practitioners to modify the management strategies, thereby lessening the severity of CRS and enhancing the results of the interventions. Such an opportunity to forecast and control CRS has made CAR T-cell therapy possible for more NHL patients.</span></p> <h3><b>Managing Neurotoxicity in CAR T-Cell Therapy</b></h3> <p><span style="font-weight: 400;">Neurotoxicity is another major complication of CAR T-cell therapy. Other than CRS, neurotoxicity. L-asparaginase is known to cause this condition that may be characterized by confusion, seizures, or even coma, through the systemic inflammation that is likely to be caused by the therapy. Similarly, further attention to neurotoxicity is paid, and the measures to reduce its impact are being adjusted with time, as is the case with CRS.</span></p> <p><span style="font-weight: 400;">Outcomes of studies have shown that there is a possibility that the development of neurotoxicity might be associated with the same markers that cause CRS, and therefore the two are related complications. From this realization, there has been a formulation of a combined management approach that deals with both conditions at the same time. For instance, the application of corticosteroids and other immunosuppressive agents has been investigated in attempts to mitigate the inflammatory processes resulting in neurotoxicity, hence enhancing the safety of CAR T-cell therapy.</span></p> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Yearwise Publication Trend on <b>“<a href="https://cancerscience.net/publication-trends/index/non hodgkins lymphoma" target="_blank" title="non hodgkins lymphoma - yearwise publication trends">non hodgkins lymphoma</a>”</b></h2> </div> </div><div class="results-container"><div class="chart-block" style="padding:15px;"> <div class="left"> <div id="results" class="results"></div> </div> <div class="right"> <div class="chart-container"><canvas id="publicationChart"></canvas></div> </div> <div class="keywordsdiv"> <div style="text-align:center;"><b>Find publication trends on relevant topics</b> </div> <span class="gp-icon icon-tags"><svg viewBox="0 0 512 512" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" width="1em" height="1em"><path d="M20 39.5c-8.836 0-16 7.163-16 16v176c0 4.243 1.686 8.313 4.687 11.314l224 224c6.248 6.248 16.378 6.248 22.626 0l176-176c6.244-6.244 6.25-16.364.013-22.615l-223.5-224A15.999 15.999 0 00196.5 39.5H20zm56 96c0-13.255 10.745-24 24-24s24 10.745 24 24-10.745 24-24 24-24-10.745-24-24z"></path><path d="M259.515 43.015c4.686-4.687 12.284-4.687 16.97 0l228 228c4.686 4.686 4.686 12.284 0 16.97l-180 180c-4.686 4.687-12.284 4.687-16.97 0-4.686-4.686-4.686-12.284 0-16.97L479.029 279.5 259.515 59.985c-4.686-4.686-4.686-12.284 0-16.97z"></path></svg></span> <span id="keyword-stats"></span> </div> </div></div></div><div class="inside-article"><style> table { margin: 0 0 1.5em; 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if (!statistics || Object.keys(statistics).length === 0) { resultsContainer.innerHTML = '<p>No data found.</p>'; return; } var tableHTML = `<div class='pub-scroll'> <table class='tablediv' border='1' cellspacing='0' cellpadding='0'> <tr> <th>Year</th> <th>Publication Count</th> </tr>`; Object.entries(statistics).sort(([yearA], [yearB]) => yearB - yearA).forEach(([year, count]) => { const displayCount = count === 0 ? 'NA' : count; tableHTML += ` <tr> <td>${year}</td> <td>${displayCount}</td> </tr> `; }); tableHTML += '</table></div>'; resultsContainer.innerHTML = tableHTML; } function displayLineChart(statistics) { var years = Object.keys(statistics); var counts = Object.values(statistics); var ctx = document.getElementById('publicationChart').getContext('2d'); // Destroy existing chart instance if it exists if (chart !== null) { chart.destroy(); } // Create a new chart instance chart = new Chart(ctx, { type: 'line', data: { labels: years, datasets: [{ label: 'Publication Counts', data: counts, fill: false, borderColor: 'rgba(75, 192, 192, 1)', tension: 0.1 }] }, options: { scales: { y: { beginAtZero: true } }, plugins: { legend: { display: true, position: 'top' } } } }); } function displayKeywordStats(keywords) { var resultsContainer = document.getElementById('keyword-stats'); resultsContainer.innerHTML = ''; if (!keywords || keywords.length === 0) { resultsContainer.innerHTML = '<p>No data found.</p>'; return; } var keywordHTML = ''; keywords.forEach((key, index) => { let key_replace = key.replace(/ /g, '-'); key_replace = key_replace.toLowerCase(); keywordHTML += `<a href="https://cancerscience.net/publication-trends/index/${key_replace}" target="_blank" title="${key} - yearwise publication trends">${key}</a>`; if (index < keywords.length - 1) { keywordHTML += ', '; } }); resultsContainer.innerHTML = keywordHTML; } // Call the function with the PHP data var statistics = { "2014": 8, "2015": 10, "2016": 8, "2017": 11, "2018": 10, "2019": 12, "2020": 18, "2021": 17, "2022": 23, "2023": 24, "2024": 17 }; var keywordsArray = ["Non-Hodgkin\u2019s lymphoma","CAR T-cell therapy","immunotherapy","cytokine release syndrome","neurotoxicity","biomarkers","B-cell malignancies","diffuse large B-cell lymphoma","relapsed lymphoma","refractory lymphoma"]; displayResults(statistics); displayLineChart(statistics); displayKeywordStats(keywordsArray); </script></p> <h3><b>Innovations in Treatment-Resistant NHL</b></h3> <p><span style="font-weight: 400;">Patients who have relapsed or are refractory from first-line NHL treatment have been few in the past. But these have been given a new lease of life by an emerging cure known as CAR T-cell therapy. Finally, patients with DLBCL who have failed standard chemotherapy have also received benefits from this therapy, and many of these patients have been rendered into remission.</span></p> <p><span style="font-weight: 400;">Thus, one of the important reasons that defines the great performance of CAR T-cell therapy in these patients is its approach. For instance, in some CAR T-cell products, the proportion of CD4+ T cells to CD8+ T cells can be altered to enhance the treatment’s effectiveness and reduce its side effects. In this way, by adjusting this ratio, clinicians manage to gain the most out of the therapy, achieving better results with fewer side effects.</span></p> <p><span style="font-weight: 400;">Moreover, CAR T-cell therapy has been combined with other treatments, like lymphodepletion chemotherapy, to improve the impact of the therapy. Research has shown that administering chemotherapy before the CAR T-cell infusion helps in the duration and number of CAR T-cells they can circulate in the patient’s body, all to produce longer remission periods.</span></p> <h3><b>The Impact of Biomarkers on Personalized Treatment</b></h3> <p><span style="font-weight: 400;">The discovery of predictive biomarkers has been revolutionary in the treatment of NHL with immunotherapy. Biomarkers are also employed for prognostic and predictive purposes; that is, for predicting both risks of toxicities, such as CRS and neurotoxicity, and benefits of CAR T-cell treatment, that is, identifying patients who are likely to benefit most from the treatment.</span></p> <p><span style="font-weight: 400;">For example, increased concentrations of cytokines IL-6 and IFN-γ do correlate with a better prognosis when patients are subjected to CAR T-cell therapy. It should be noted that such biomarkers are useful in improving the identification of the patients most likely to benefit from the treatment while minimizing the consequences of serious side effects.</span></p> <p><span style="font-weight: 400;">However, more studies are being conducted to identify new biomarkers that could bring more clarity to the identification of patients eligible for CAR T-cell therapy. </span><span style="font-weight: 400;">This way, the further definition of molecular and genetic bases of treatment response may advance the optimization of immunotherapy safety and effectiveness in NHL.</span></p> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Recent Publications on <b>“<a href="https://cancerscience.net/recent-publications/index/non hodgkins lymphoma" target="_blank" rel="noopener" title="non hodgkins lymphoma - yearwise publication list">non hodgkins lymphoma</a>”</b></h2> </div> </div> <div class="pb-main"><div class="article-scroll"><div id="results_recent" class="results"></div></div><div class="keywordsdiv" style="margin: 0px 15px;margin-top:20px;"> <div style="text-align:center;"><b>Find publications on relevant topics</b> </div> <span class="gp-icon icon-tags"><svg viewBox="0 0 512 512" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" width="1em" height="1em"><path d="M20 39.5c-8.836 0-16 7.163-16 16v176c0 4.243 1.686 8.313 4.687 11.314l224 224c6.248 6.248 16.378 6.248 22.626 0l176-176c6.244-6.244 6.25-16.364.013-22.615l-223.5-224A15.999 15.999 0 00196.5 39.5H20zm56 96c0-13.255 10.745-24 24-24s24 10.745 24 24-10.745 24-24 24-24-10.745-24-24z"></path><path d="M259.515 43.015c4.686-4.687 12.284-4.687 16.97 0l228 228c4.686 4.686 4.686 12.284 0 16.97l-180 180c-4.686 4.687-12.284 4.687-16.97 0-4.686-4.686-4.686-12.284 0-16.97L479.029 279.5 259.515 59.985c-4.686-4.686-4.686-12.284 0-16.97z"></path></svg></span> <span id="keyword-papers"></span> </div></div></div><div class="inside-article"> <style> .pb-main{ border: solid 1px #ccc; border-top: none; margin-bottom: 20px; padding-bottom: 25px; background:#fff; } .author-main { border: solid 1px #ccc; border-top: none; margin-bottom: 20px; padding-bottom: 25px; background:#fff; } .publication-block { padding: 10px; margin-bottom: 10px; background-color: #f9f9f9; text-align: left; background: #FFF; border-bottom: solid 1px #ccc; margin-left: 15px; margin-right: 15px; } .publication-block h3 { margin: 0 0 10px; color: #000!important; } .publication-block a { font-size: 16px !important; line-height: 1em; font-weight: 600; text-transform: none; color: #000; padding: 0px; } .publication-block a:hover{ color: #227cdc; text-decoration:underline; } .article-scroll { max-height: 445px; overflow-y: auto; overflow-x: hidden; } ::-webkit-scrollbar-track { -webkit-box-shadow: inset 0 0 6px rgba(0,0,0,0.3); background-color: #efefef; border-radius:30px; } ::-webkit-scrollbar { width: 6px; background-color: #efefef; border-radius:30px; } ::-webkit-scrollbar-thumb { background-color: #ababab; border-radius:30px; } .publication-block p { margin-bottom: .5em; font-size: 15px; color: #000; } h3 { font-size: 18px !important; margin-bottom: 20px; line-height: 1.2em; font-weight: 600; text-transform: none; } a { padding: 5px; color: #a71c49; } #keyword-papers{ margin-top: 20px; text-align: center; } </style> <script> function displayResults_recent(papers) { var resultsContainer = document.getElementById('results_recent'); if (!papers || papers.length === 0) { resultsContainer.innerHTML = '<p>No recent publications found.</p>'; return; } papers.forEach(paper => { var publicationBlock = document.createElement('div'); publicationBlock.className = 'publication-block'; var publicationHTML = ` <div style="margin-bottom: 10px;line-height: 24px;"><a href="${paper.url}" target="_blank" title="${paper.title}">${paper.title}</a></div> <p><strong>Issue Release:</strong> ${paper.publishedDate}</p> `; publicationBlock.innerHTML = publicationHTML; resultsContainer.appendChild(publicationBlock); }); } function displayKeywordPapers(keywords) { var resultsContainer = document.getElementById('keyword-papers'); resultsContainer.innerHTML = ''; if (!keywords || keywords.length === 0) { resultsContainer.innerHTML = '<p>No data found.</p>'; return; } var keywordHTML = ''; keywords.forEach((key, index) => { let key_replace = key.replace(/ /g, '-'); key_replace = key_replace.toLowerCase(); keywordHTML += `<a href="https://cancerscience.net/recent-publications/index/${key_replace}" target="_blank" title="${key} - publication list">${key}</a>`; if (index < keywords.length - 1) { keywordHTML += ', '; } }); resultsContainer.innerHTML = keywordHTML; } // Call the function with the PHP data var recent_papers = [ { "title": "A rare case report of hemophagocytic lymphohistiocytosis secondary to pure eythroid leukemia in a person living with HIV.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/39172105", "publishedDate": "2024" }, { "title": "Flow cytometry is a sensitive technique to assess marrow involvement by B cell non-Hodgkins lymphoma.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38486446", "publishedDate": "2024" }, { "title": "Noncoding RNAs in B cell non-Hodgkins lymphoma.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38636814", "publishedDate": "2024" }, { "title": "Anti-CD19 chimeric antigen receptor T-cell therapy has less efficacy in Richter transformation than in large B-cell lymphoma and transformed low-grade B-cell lymphoma.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38899351", "publishedDate": "2024" }, { "title": "When Sarcomas Mimic Lymphomas: A BCOR-Rearranged Sarcoma Case Report.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38544655", "publishedDate": "2024" }, { "title": "Long-Term Results of IFRT vs. ISRT in Infradiaphragmal Fields in Aggressive Non-Hodgkins\\\\\\'s Lymphoma Patients-A Single Centre Experience.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38339400", "publishedDate": "2024" }, { "title": "Cancer Incidence Trends in Successive Social Generations in the US.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38857048", "publishedDate": "2024" }, { "title": "Management of Patients undergoing CAR-T cell therapy in Germany.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/38198763", "publishedDate": "2024" }, { "title": "Diagnostic difficulties of antero-superior mediastinal masses with cardiac infiltration. Endovascular bioptic alternative approach.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/36660562", "publishedDate": "2023" }, { "title": "A Study of Cytomorphological Spectrum of Head and Neck Lesions in Pediatric Age Group.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/37388403", "publishedDate": "2023" }, { "title": "Post Covid Juvenile Dermatomyoscitis with Non Hodgkins Lymphoma in a Child - A Case Report.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/37005524", "publishedDate": "2023" }, { "title": "Knowledge mapping of immunotherapy for thyroid cancer from 1980 to 2022: A review.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/37773801", "publishedDate": "2023" }, { "title": "Non-Hodgkins lymphoma of the nasal cavity: A case report.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/37727145", "publishedDate": "2023" }, { "title": "Prognostic Value of Differential Expression of Polymerase Eta Gene in Nonresponding Patients With Diffuse Large B-cell Lymphoma.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/37867373", "publishedDate": "2023" }, { "title": "Curious case of bilateral non-resolving vitritis - Unmasking the masquerade on ultra-widefield imaging.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/35326082", "publishedDate": "2022" }, { "title": "Geotemporospatial and causal inferential epidemiological overview and survey of USA cannabis, cannabidiol and cannabinoid genotoxicity expressed in cancer incidence 2003-2017: part 1 - continuous bivariate analysis.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/35354487", "publishedDate": "2022" }, { "title": "Orbital Tumors and Tumor like Lesions: A Hospital Based Study.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/35945849", "publishedDate": "2022" }, { "title": "BDP1 as a biomarker in serous ovarian cancer.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/36305848", "publishedDate": "2022" }, { "title": "Prognostic value of combined MTV and ADC derived from baseline FDG PET\/MRI in aggressive non-Hodgkins lymphoma.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/36319985", "publishedDate": "2022" }, { "title": "Role of high acquisition flow cytometry in the detection of marrow involvement in patients with extramedullary B cell non-Hodgkins lymphoma: a comparison with marrow aspirate cytology, trephine biopsy, and PET.", "url": "https:\/\/pubmed.ncbi.nlm.nih.gov\/35819878", "publishedDate": "2022" } ]; var keywordsArray = ["Non-Hodgkin\u2019s lymphoma","CAR T-cell therapy","immunotherapy","cytokine release syndrome","neurotoxicity","biomarkers","B-cell malignancies","diffuse large B-cell lymphoma","relapsed lymphoma","refractory lymphoma"]; displayResults_recent(recent_papers); displayKeywordPapers(keywordsArray); </script></p> <h3><b>Future Directions in Immunotherapy for NHL</b></h3> <p><span style="font-weight: 400;">With the development of research and knowledge in the field of immunology, the future of immunotherapy for NHL is rather bright. </span><span style="font-weight: 400;">New generations of CAR T-cell therapies are under discussion; they are intended to build on the achievements of the existing therapies but also avoid their pitfalls. Therefore, the next generation of therapies may embrace dual-targeting of CAR T-cells that will recognize more than one antigen, which may help in providing better chances for patients with complex or heterogeneous malignancies.</span></p> <p><span style="font-weight: 400;">Apart from CAR T-cells, other immunotherapies are also in development for NHL treatment. These are the immune checkpoint inhibitors that can boost the body’s immune system against cancer and bispecific T-cell engagers, which can refocus T-cells towards targeting the cancerous cells.</span></p> <p><span style="font-weight: 400;">In addition, combined immunotherapy with other forms of treatment such as chemotherapy, radiotherapy, and stem cell transplantation enhances the overall treatment of NHL. Integrating these approaches allows clinicians to create substantially more individual and efficient treatment regimens for addressing many of the difficulties inherent in each patient’s disease.</span></p> <h3><b>Conclusion</b></h3> <p><span style="font-weight: 400;">Indeed, the progress that has been made in immunotherapy for non-Hodgkin’s lymphoma has been revolutionary by all means. CAR T-cell therapy especially has moved the needle on treatment and has become a ray of hope for patients who have run out of other available solutions. Despite these problems, the constant improvement in management techniques suggesting biomarkers for the identification of appropriate clients makes this therapy more available and safer for more sufferers. Immunotherapy in the NHL is still a topic of research, and as with any field, it only gets better; the future for immunotherapy in the NHL is looking brighter for patients and their need for effective and new treatments.</span></p> <p></p> <h3><b>References</b></h3> <ol> <li>Crump, M., Neelapu, S.S., Farooq, U., Van Den Neste, E., Kuruvilla, J., Westin, J., Link, B.K., Hay, A., Cerhan, J.R., Zhu, L. and Boussetta, S., 2017. <a href="https://ashpublications.org/blood/article/130/16/1800/36474/Outcomes-in-refractory-diffuse-large-B-cell">Outcomes in refractory diffuse large B-cell lymphoma: results from the international SCHOLAR-1 study. </a><i>Blood, The Journal of the American Society of Hematology</i>, <i>130</i>(16), pp.1800-1808.</li> <li>Kochenderfer, J.N., Somerville, R.P., Lu, T., Shi, V., Bot, A., Rossi, J., Xue, A., Goff, S.L., Yang, J.C., Sherry, R.M. and Klebanoff, C.A., 2017. <a href="https://ascopubs.org/doi/full/10.1200/JCO.2016.71.3024">Lymphoma remissions caused by anti-CD19 chimeric antigen receptor T cells are associated with high serum interleukin-15 levels.</a> <i>Journal of clinical oncology</i>, <i>35</i>(16), pp.1803-1813.</li> <li>Turtle, C.J., Hanafi, L.A., Berger, C., Hudecek, M., Pender, B., Robinson, E., Hawkins, R., Chaney, C., Cherian, S., Chen, X. and Soma, L., 2016. <a href="https://www.science.org/doi/abs/10.1126/scitranslmed.aaf8621">Immunotherapy of non-Hodgkin’s lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor–modified T cells.</a> <i>Science translational medicine</i>, <i>8</i>(355), pp.355ra116-355ra116.</li> <li>Teachey, D.T., Lacey, S.F., Shaw, P.A., Melenhorst, J.J., Maude, S.L., Frey, N., Pequignot, E., Gonzalez, V.E., Chen, F., Finklestein, J. and Barrett, D.M., 2016. <a href="https://aacrjournals.org/cancerdiscovery/article/6/6/664/5936/Identification-of-Predictive-Biomarkers-for">Identification of predictive biomarkers for cytokine release syndrome after chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. </a><i>Cancer discovery</i>, <i>6</i>(6), pp.664-679.</li> <li>Turtle, C.J., Hanafi, L.A., Berger, C., Gooley, T.A., Cherian, S., Hudecek, M., Sommermeyer, D., Melville, K., Pender, B., Budiarto, T.M. and Robinson, E., 2016. <a href="https://www.jci.org/articles/view/85309">CD19 CAR–T cells of defined CD4+: CD8+ composition in adult B cell ALL patients. </a><i>The Journal of clinical investigation</i>, <i>126</i>(6), pp.2123-2138.</li> <li>Schuster, S.J., Svoboda, J., Nasta, S.D., Porter, D.L., Chong, E.A., Landsburg, D.J., Mato, A.R., Lacey, S.F., Melenhorst, J.J., Chew, A. and Hasskarl, J., 2015. <a href="https://www.sciencedirect.com/science/article/pii/S0006497118471625">Sustained remissions following chimeric antigen receptor modified T Cells directed against CD19 (CTL019) in patients with relapsed or refractory CD19+ lymphomas.</a> <i>Blood</i>, <i>126</i>(23), p.183.</li> <li>Kochenderfer, J.N., Dudley, M.E., Kassim, S.H., Somerville, R.P., Carpenter, R.O., Stetler-Stevenson, M., Yang, J.C., Phan, G.Q., Hughes, M.S., Sherry, R.M. and Raffeld, M., 2015. <a href="https://ascopubs.org/doi/full/10.1200/JCO.2014.56.2025">Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor.</a> <i>Journal of clinical oncology</i>, <i>33</i>(6), pp.540-549.</li> </ol> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Top Experts on “<b style="color:#000;font-size:22px;">non hodgkins lymphoma</b>“</h2> </div> </div><div class="author-main"><div id="results_author"></div><div style="text-align: center;"><a class="register-button" href="https://cancerscience.net/expert-search" target="_blank" rel="noopener">Find experts on any field</a></div></div><div class="inside-article" style="background: none;border: none;box-shadow: none;margin-top: -70px;"> <style> .author-block { padding: 15px; 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", "email": "guoanche@umich.edu", "slug_tail": "guoan-chen" }, "D_tpK4wBWBy50K-rvVK6": { "aid": "D_tpK4wBWBy50K-rvVK6", "name": "Meeta Singh", "citation_count": 484, "hindex": 12, "paper_count": 93, "affiliation": "Department of Pathology, Maulana Azad Medical College, New Delhi, India. ", "email": "meetamamc@gmail.com", "slug_tail": "meeta-singh" }, "f2dIK4wBWBy50K-ru8du": { "aid": "f2dIK4wBWBy50K-ru8du", "name": "A. Sheikh", "citation_count": 719, "hindex": 11, "paper_count": 33, "affiliation": "Department of Cardiology, University Hospital of Wales, Heath Park Way, Cardiff CF14 4XW, UK, ", "email": "drazeemsheikh@hotmail.com", "slug_tail": "a-sheikh" }, "zm3HK4wBWBy50K-rt8--": { "aid": "zm3HK4wBWBy50K-rt8--", "name": "M. Lorsbach", "citation_count": 33, "hindex": 3, "paper_count": 9, "affiliation": "Stabsstelle f\u00fcr Telemedizin, Universit\u00e4tsklinikum M\u00fcnster, H\u00fcfferstra\u00dfe 73-79, 48149, M\u00fcnster, Deutschland. 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