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<header class="l-header" role="banner"> <div class="l-header__inner"> <div class="l-constrain"> <a class="c-site-name c-site-name--logo" href="/" rel="home"> <span class="c-logo c-logo--header"> <img class="c-logo__image" src="/sites/default/files/2024-08/CryoEM_icon_RGB.svg" alt="" loading="lazy" width="" height=""/> </span> <span class="c-site-name__acronym">CryoEM</span><span class="c-site-name__text"><span>Stanford-SLAC</span> <span>CryoEM Facilities</span></span> </a> <div class="l-header__freeform"> </div> <div class="c-search c-search--dropdown"> <button class="c-search__button" aria-expanded="true" aria-controls="search-form--AHDWlqIAQlg"> Search <svg class="c-icon c-search--dropdown" aria-hidden="true"><use xlink:href="/themes/contrib/slac-drupal-profile-theme/dist/images/sprite.artifact.svg#search"></use></svg> </button> <form class="c-search__form" id="search-form--AHDWlqIAQlg" method="get" hidden tabindex="-1"> <div class="l-constrain l-constrain--small"> <div 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/sites/default/files/styles/image_hero_2x/public/2023-10/Arrillaga_Science_Center.jpg?h=493986d8&itok=u-Jzmf-M 2880w" sizes="100vw" width="2880" height="1536" src="/sites/default/files/styles/image_hero_0_25x/public/2023-10/Arrillaga_Science_Center.jpg?h=493986d8&itok=j1dcSuLj" alt="exterior of Arrillaga Science Center with tree and clear sky" /> <div class="c-hero-bg-image__content"> <div class="l-constrain"> <div class="c-hero-bg-image__overlay"> <div class="c-hero-bg-image__title">CryoEM and CryoET at SLAC</div> <div class="c-hero-bg-image__summary"> <div class="c-field c-field--name-field-body c-field--type-text-long c-field--label-hidden"> <div class="c-field__content"><p>The CryoEM (cryogenic electron microscopy) facility at SLAC, built and operated in partnership with Stanford University, is equipped with multiple state-of-the-art instruments for cryoEM.</p> </div></div> </div> </div> </div> </div> <div class="l-constrain c-hero-bg-image__caption"> <div class="c-tooltip c-tooltip--align-left"> <button class="c-tooltip__button" aria-label="More information" aria-controls="caption--3EiZdgz9aZA"> <svg class="c-icon c-tooltip--align-left" aria-hidden="true"><use xlink:href="/themes/contrib/slac-drupal-profile-theme/dist/images/sprite.artifact.svg#info"></use></svg> </button> <div class="c-tooltip__tooltip" hidden id="caption--3EiZdgz9aZA" role="tooltip"><p>View of SLAC's Arrillaga Science Center.</p><p><em class="c-tooltip__credit">Jacqueline Orrell/SLAC National Accelerator Laboratory</em></p></div> </div> </div> </div> <div class="l-section l-section--no-padding l-section--margin-home-space"> <div class="l-section__content l-constrain"> <div class="c-wysiwyg"> <div data-drupal-messages-fallback class="hidden"></div> </div> </div> </div> <section class="l-section--dark l-section--blue-green c-paragraph c-paragraph--type-section c-paragraph--view-mode-default l-section"> <div class="l-constrain"> <h2 class="l-section__title"> Facilities </h2> <div class="l-section__content"> <div class="l-grid l-grid--3-col"> <div class="c-card--link c-card c-card--no-link"> <div class="c-card__body"> <div class="c-card__header"> <h3 class="c-card__title h5"> Stanford-SLAC CryoEM Center (S2C2) </h3> </div> <div class="c-card__content"> <div class="c-field c-field--name-field-body c-field--type-text-long c-field--label-hidden"> <div class="c-field__content"><p>The Stanford-SLAC CryoEM Center (S2C2) provides access to state-of-the-art cryoEM instruments for data collection towards atomic resolution structure determination of biochemically purified single particles and enables scientists across the nation to become independent cryoEM investigators. The S2C2 is supported by the National Institutes of Health Common Fund <a href="https://commonfund.nih.gov/cryoem"><strong>Transformative High Resolution Cryo-Electron Microscopy</strong></a> program.</p> <p> </p> <p>Project applications for S2C2 are due on the first day of each month and are generally reviewed within the same month. See <a href="https://s2c2.slac.stanford.edu/user-access-processes/user-access"><strong>User Access</strong></a> for more information.</p> </div></div> <ul class="c-card__list"> <li><a href="https://s2c2.slac.stanford.edu/" class="c-cta-link">S2C2 Home Page</a></li> </ul> </div> </div> <div class="c-card__media"> <img loading="lazy" src="/sites/default/files/styles/card/public/2023-07/Patrick%20contollers%20TEM%20Room%20400%20px%20width_0.jpg?h=ea22e8d8&itok=oeH97-FK" width="600" height="300" alt="Patrick at controls in one of the three TEM rooms" /> </div> </div> <div class="c-card--link c-card c-card--no-link"> <div class="c-card__body"> <div class="c-card__header"> <h3 class="c-card__title h5"> Stanford-SLAC CryoET Specimen Preparation Center (SCSC) </h3> </div> <div class="c-card__content"> <div class="c-field c-field--name-field-body c-field--type-text-long c-field--label-hidden"> <div class="c-field__content"><p>SCSC is one of the four service centers of a National Network for CryoElectron Tomography, coordinated by a central network hub. The service centers will specialize in cryoET specimen preparation. The hub will perform cryoET data collection for all user laboratories served by the network, in addition to its service center functions. The SCSC is supported by the <a href="http://commonfund.nih.gov/cryoem"><strong>National Institutes of Health Common Fund Microscopy</strong></a> Program.</p> </div></div> <ul class="c-card__list"> <li><a href="https://scsc.slac.stanford.edu/" class="c-cta-link">SCSC Home Page</a></li> </ul> </div> </div> <div class="c-card__media"> <img loading="lazy" src="/sites/default/files/styles/card/public/2023-07/Rahel%20SCSC.jpg?h=b2709eee&itok=zhwJatkA" width="600" height="300" alt="Postdoc working on Krios at SLAC National Accelerator Lab" /> </div> </div> </div> </div> </div> </section> <section class="l-section"> <div class="l-constrain"> <div class="l-section__content"> <div class="c-wysiwyg"> </div> </div> </div> </section> <section class="l-section--dark l-section--purple-black c-paragraph c-paragraph--type-section c-paragraph--view-mode-default l-section"> <div class="l-constrain"> <h2 class="l-section__title"> Affiliated CryoEM and CryoET Research Groups </h2> <div class="l-section__content"> <div class="l-grid l-grid--3-col"> <div class="c-card c-card--no-link c-card--no-link"> <div class="c-card__body"> <div class="c-card__header"> <h3 class="c-card__title h5"> Chen Lab </h3> </div> <div class="c-card__content"> <div class="c-field c-field--name-field-body c-field--type-text-long c-field--label-hidden"> <div class="c-field__content"><p>Research in the Chen lab focuses on developing computational methods that process CryoEM and CryoET data to reveal the 3D structure and dynamics of macromolecules. We design and adapt machine-learning-based algorithms for a wide range of CryoEM/ET applications, such as resolving protein structural variability for single particle analysis, building molecular models from CryoEM density maps, as well as identifying proteins inside cells and solving their structures from CryoET data. Through collaboration with multiple groups across the US, we also study various biological processes, including virus assembly and infection, the structure and mechanism of membrane channels, and the photosynthesis process in algae.</p> </div></div> </div> </div> <div class="c-card__media"> <img loading="lazy" src="/sites/default/files/styles/card/public/2024-10/PastedGraphic-1.png?h=56a14a0e&itok=ri_8qSlE" width="600" height="300" alt="Pasted Graphic from Muyuan Chen's Movie" /> </div> </div> <div class="c-card--link c-card c-card--no-link"> <div class="c-card__body"> <div class="c-card__header"> <h3 class="c-card__title h5"> Chiu Lab </h3> </div> <div class="c-card__content"> <div class="c-field c-field--name-field-body c-field--type-text-long c-field--label-hidden"> <div class="c-field__content"><p>Research in the Chiu lab includes methodology improvements in single particle cryoEM for atomic resolution structure determination of molecules and molecular machines, as well as in cryoET of cells and organelles towards subnanometer resolutions.</p> <p>We collaborate with many researchers in and outside of the Stanford community on understanding biological processes such as protein folding, ion transports, RNA folds, virus assembly and disassembly, pathogen-host interactions, and neurodegenerations.</p> </div></div> <ul class="c-card__list"> <li><a href="https://www.wahchiulab.org" class="c-cta-link">Chiu Lab</a></li> </ul> </div> </div> <div class="c-card__media"> <img loading="lazy" src="/sites/default/files/styles/card/public/2023-07/Chiulab%20pic400.jpg?h=3b5d1417&itok=7ReU3YWV" width="600" height="300" alt="Chiu Lab staff" /> </div> </div> <div class="c-card--link c-card c-card--no-link"> <div class="c-card__body"> <div class="c-card__header"> <h3 class="c-card__title h5"> Dahlberg Lab </h3> </div> <div class="c-card__content"> <div class="c-field c-field--name-field-body c-field--type-text-long c-field--label-hidden"> <div class="c-field__content"><p>The Dahlberg lab focuses on methodological development in the area of correlative light and electron microscopy. Separately, electron tomography and fluorescence microscopy have emerged as powerful methods for observing subcellular organization and biomolecular function <em>in situ. </em>However, each approach has strengths and weakness that are often complementary. Combining the two into one correlative approach keeps the best of both techniques while mitigating the weaknesses. </p> <p>Check out the website to learn more about the research and the lab members at the forefront of this exciting space.</p> </div></div> <ul class="c-card__list"> <li><a href="https://web.slac.stanford.edu/dahlberglab/" class="c-cta-link">Dahlberg Lab</a></li> </ul> </div> </div> <div class="c-card__media"> <img loading="lazy" src="/sites/default/files/styles/card/public/2024-04/Group_photo_cropped_0.jpg?h=0a819169&itok=85PZR1gc" width="600" height="300" alt="Dahlberg's Lab Staff" /> </div> </div> <div class="c-card c-card--no-link c-card--no-link"> <div class="c-card__body"> <div class="c-card__header"> <h3 class="c-card__title h5"> Oliver Lab </h3> </div> <div class="c-card__content"> <div class="c-field c-field--name-field-body c-field--type-text-long c-field--label-hidden"> <div class="c-field__content"><p>To reveal molecular mechanisms that underpin virus replication and pathogenesis, the Oliver lab employs innovative research strategies by combining sophisticated bioimaging modalities, including cryogenic electron microscopy approaches, with multi-omic technologies and functional assays. We scrutinize how viruses like herpes manipulate host cells, utilizing structural biology to capture viral machinery in detail and combine it with multi-omics to decode host-pathogen interactions. Our state-of-the-art approaches are designed to reveal unconceived therapeutic targets by advancing knowledge of viral strategies to subvert host molecular controls of replication to inform antiviral development.</p> </div></div> </div> </div> <div class="c-card__media"> <img loading="lazy" src="/sites/default/files/styles/card/public/2024-10/Oliver%20lab%20Pic.JPG?h=92229be0&itok=qKjqge9L" width="600" height="300" alt="Oliver Lab at SLAC National Accelerator Laboratory" /> </div> </div> </div> </div> </div> </section> <section class="l-section"> <div class="l-constrain"> <div class="l-section__content"> <div class="u-slide-left c-promo-box--small c-promo-box"> <div class="c-promo-box__col"> <div class="c-kicker"> Use of our CryoEM Facilities Require </div> <h2 class="c-promo-box__title"> Acknowledgements </h2> </div> <div class="c-promo-box__col c-promo-box__content"> <a href="https://s2c2.slac.stanford.edu/publications/s2c2-acknowledgement">S2C2 Acknowledgement Page</a><a href="https://scsc.slac.stanford.edu/acknowledgement">SCSC Acknowledgement Page</a> </div> </div> </div> </div> </section> <section class="c-paragraph c-paragraph--type-embed-block-content c-paragraph--view-mode-default l-section l-section--no-padding"> <div class="l-constrain"> <div class="l-section__content"> <div class="c-paragraph c-paragraph--type-embed-block-content c-paragraph--view-mode-default"> <div class="c-field c-field--name-field-block-content c-field--type-block-field c-field--label-hidden"> <div class="c-field__content"> <div id="block-trendingnewsfeed" class="c-promo-box"> <div class="c-promo-box__col"> <div class="c-kicker"> </div> <h2 class="c-promo-box__title"> Related News </h2> </div> <div class="c-promo-box__col c-promo-box__content"> <ul><li><a href="https://www6.slac.stanford.edu/news/2023-11-14-how-tiny-hinges-bend-infection-spreading-spikes-coronavirus" hreflang="en">How tiny hinges bend the infection-spreading spikes of a coronavirus </a></li><li><a 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