Computational Approach to the Interaction of Neurotoxins and Kv1.3 Channel

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Interaction of Neurotoxins and Kv1.3 Channel</title> <meta name="description" content="Computational Approach to the Interaction of Neurotoxins and Kv1.3 Channel"> <meta name="keywords" content="neurotoxins, potassium channel, Kv1.3, computational methods, autoimmune diseases"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img 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publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">Computational Approach to the Interaction of Neurotoxins and Kv1.3 Channel</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Janneth%20Gonz%C3%A1lez">Janneth Gonz谩lez</a>, <a href="https://publications.waset.org/abstracts/search?q=George%20Barreto"> George Barreto</a>, <a href="https://publications.waset.org/abstracts/search?q=Ludis%20Morales"> Ludis Morales</a>, <a href="https://publications.waset.org/abstracts/search?q=Ang%C3%A9lica%20Sabogal"> Ang茅lica Sabogal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sea anemone neurotoxins are peptides that interact with Na+ and K+ channels, resulting in specific alterations on their functions. Some of these neurotoxins (1ROO, 1BGK, 2K9E, 1BEI) are important for the treatment of nearly eighty autoimmune disorders due to their specificity for Kv1.3 channel. The aim of this study was to identify the common residues among these neurotoxins by computational methods, and establish whether there is a pattern useful for the future generation of a treatment for autoimmune diseases. Our results showed eight new key common residues between the studied neurotoxins interacting with a histidine ring and the selectivity filter of the receptor, thus showing a possible pattern of interaction. This knowledge may serve as an input for the design of more promising drugs for autoimmune treatments. <iframe src="https://publications.waset.org/abstracts/8452.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=neurotoxins" title="neurotoxins">neurotoxins</a>, <a href="https://publications.waset.org/abstracts/search?q=potassium%20channel" title=" potassium channel"> potassium channel</a>, <a href="https://publications.waset.org/abstracts/search?q=Kv1.3" title=" Kv1.3"> Kv1.3</a>, <a href="https://publications.waset.org/abstracts/search?q=computational%20methods" title=" computational methods"> computational methods</a>, <a href="https://publications.waset.org/abstracts/search?q=autoimmune%20diseases" title=" autoimmune diseases"> autoimmune diseases</a> </p> <a 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Computational Approach to the Interaction of Neurotoxins and Kv1.3 Channel