Multisystem Inflammatory Syndrome in Children (MIS-C)

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} </script> <script src="//translate.google.com/translate_a/element.js?cb=googleTranslateElementInit"></script> </ul> </div> </nav> <div class="container-fluid bg-grey"> <div class="container pt-3 pb-4"> <div class="white-container mt-4"> <h2 class="bg-hdr">Multisystem Inflammatory Syndrome in Children (MIS-C) </h2> <p>During pandemic COVID-19 in majority of children presented less severe phenotype, multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 subsequently evolved as a post-infectious inflammatory condition associated with severe clinical deterioration and multi organ involvement.</p> <p>Aim of the study was to assess the clinical and lab characteristics and outcomes of MIS-C in Georgia. The study comprised 89 children with MIS-C admitted to Iashvili children’s central hospital from December 2020 to October 2022. Data were obtained from medical record retrospectively.</p> <p>58 (54.2%) of patients were male. Median age of patients was 8.5 (1-17) years. The most common presenting symptoms were - fever (100%), gastrointestinal (GI) (68%), rash (48.1%) and vomiting (46%) were. Average fever duration was 9 (4 -12) days. Shock and/or hypotension were common in patients with MIS-C (24%). In total, 38.7% of the patients admitted to pediatric intensive care unit and 19.3% received vasopressor support. 20% of patient had depressed left ventricular ejection fraction. Cardiac symptoms (69%) predominated over respiratory (40%) and neurological (32%) symptoms. Admission lab findings - elevated CRP -99.8%, procalcitonine-97.1%, erythrocyte sedimentation rate-98%, D-dimer-98.8% and ferritin-78%; Lymphopenia-98.9%, neutrophilia - 96% and hypoalbuminemia 40.3%. 38% received IV Intravenous immunoglobulin, 98.2% - corticosteroids; Anakinra was not used in our clinic. Median duration of hospital length of stay was 14.5 days. Comorbidities were present in 1.1% of the patients. No mortality was recorded.</p> <p>While being rare MIS-C has very severe presentation that need early recognition and aggressive treatment. The increasing number of MIS-C cases shows that this phenomenon is more common than was thought at the beginning of pandemic. Here is not enough evidence about the long-term consequences yet and we conduct monitoring and evaluation of patients in dynamics.</p> <p><strong>Keywords: </strong>COVID-19; SARS-CoV2; children; multisystem inflammatory syndrome in children (MIS-C).</p> <div class="border-top py-2"><b>Posted by: </b>Ana, pediatrician, Iashvili children`s central hospital, Tbilisi, Georgia (<span class="f-sm">30-Sep-2023</span>)</div> </div> </div> </div> <div class="container_fluid"> <div class="bg-footer"> <div class="container py-4"> <div class="d-flex justify-content-center pt-4"> <div class="text-center f-sm"> <a href="/" title="Home page" class="text-grey me-2">Home</a><span class="me-1">|</span> <a href="/international-conferences/" title="Conferences" class="text-grey me-1">Conferences</a><span class="me-1">|</span> <a href="/international-exhibitions/" title="International Exhibition" class="text-grey me-2">Exhibitions</a><span class="me-1">|</span> <a href="/event-organizers/" title="Event 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Multisystem Inflammatory Syndrome in Children (MIS-C)