QUANTIFOIL® SiO2 Films

<!doctype html><html lang="en"><head> <meta charset="utf-8"> <title>QUANTIFOIL® SiO2 Films | Quantifoil</title> <link rel="shortcut icon" href="https://www.quantifoil.com/hubfs/Website/Admin%20Only/Logos/quantifoil-favicon.png"> <meta name="description" content="Resilient and extensively functionalizable, QUANTIFOIL® SiO2 films are robust enough to withstand extensive manual handling and FIB-milling.">  <script src="https://code.jquery.com/jquery-3.6.0.min.js" integrity="sha256-/xUj+3OJU5yExlq6GSYGSHk7tPXikynS7ogEvDej/m4=" crossorigin="anonymous"></script> <script src="https://cdn.jsdelivr.net/npm/select2@4.1.0-rc.0/dist/js/select2.min.js"></script>  <meta name="viewport" content="width=device-width, initial-scale=1"> <meta property="og:description" content="Resilient and extensively functionalizable, QUANTIFOIL® SiO2 films are robust enough to withstand extensive manual handling and FIB-milling."> <meta property="og:title" content="QUANTIFOIL® SiO2 Films | Quantifoil"> <meta name="twitter:description" content="Resilient and extensively functionalizable, QUANTIFOIL® SiO2 films are robust enough to withstand extensive manual handling and FIB-milling."> <meta name="twitter:title" content="QUANTIFOIL® SiO2 Films | Quantifoil"> <style> a.cta_button{-moz-box-sizing:content-box !important;-webkit-box-sizing:content-box !important;box-sizing:content-box !important;vertical-align:middle}.hs-breadcrumb-menu{list-style-type:none;margin:0px 0px 0px 0px;padding:0px 0px 0px 0px}.hs-breadcrumb-menu-item{float:left;padding:10px 0px 10px 10px}.hs-breadcrumb-menu-divider:before{content:'›';padding-left:10px}.hs-featured-image-link{border:0}.hs-featured-image{float:right;margin:0 0 20px 20px;max-width:50%}@media (max-width: 568px){.hs-featured-image{float:none;margin:0;width:100%;max-width:100%}}.hs-screen-reader-text{clip:rect(1px, 1px, 1px, 1px);height:1px;overflow:hidden;position:absolute !important;width:1px} </style> <link rel="stylesheet" href="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/template_assets/47338892503/1650468878724/Quantifoil-Theme-2022/css/_containers-dnd-main.min.css"> <link rel="stylesheet" href="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/template_assets/47338889188/1650468880621/Quantifoil-Theme-2022/css/_layout.min.css"> <link rel="stylesheet" href="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/template_assets/47339139305/1650468880014/Quantifoil-Theme-2022/css/bootstrap.min.css"> <link rel="stylesheet" href="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/template_assets/47338892505/1650469455533/Quantifoil-Theme-2022/css/global.min.css"> <link rel="stylesheet" href="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/template_assets/47338889189/1650468879802/Quantifoil-Theme-2022/css/animate.min.css"> <link rel="stylesheet" href="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/template_assets/47339139306/1650468879126/Quantifoil-Theme-2022/css/theme-override.min.css"> <link rel="stylesheet" href="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/module_assets/47338893017/1648550420681/module_47338893017_quantifoil-menu.min.css"> <link rel="stylesheet" href="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/module_assets/47339182789/1648550413914/module_47339182789_global_banner.min.css"> <link rel="stylesheet" href="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/module_assets/47339182781/1648550413836/module_47339182781_product_image_and__description.min.css"> <link rel="stylesheet" href="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/module_assets/47683378661/1649681182163/module_47683378661_Tabber.min.css"> <style> .hs-tabs__navitem:not(.hs-tabs__navitem--active) { background-color: #cfcfcf; 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height: auto;"> </div> <div class="product-info"> <h2></h2> <p>Resilient and extensively functionalizable, QUANTIFOIL<sup>®</sup><span> </span>SiO<sub>2</sub><span> </span>films are robust enough to withstand extensive manual handling and FIB-milling. They are a popular choice for <em>in situ</em> biological imaging including cryo-electron tomography and correlated light and electron microscopy (CLEM), as well as materials science applications.</p> <p>In addition, the ability to easily chemically modify SiO<sub>2 </sub>film surfaces makes them ideal when:</p> <ul> <li>Optimizing the physicochemical properties of the transmission electron microscopy supports.</li> <li>The sample support is part of the experimental protocol: for example directing the growth of a sample or to covalently attaching a biomolecule to the SiO<sub>2</sub><span> </span>surface.</li> </ul> </div> </div> </div> </div> </div> </div> </div>  </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-4 main_area-row-2-max-width-section-centering dnd-section main_area-row-2-vertical-alignment"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell cell_16485707706593-vertical-alignment cell_16485707706593-padding dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-5 cell_16485707706593-row-0-padding dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1648628954853" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1648628954853_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h2><span>Applications that may benefit from using SiO<sub>2</sub> supports include:</span></h2> <ul> <li>On-grid cell growth for<em> in situ</em> imaging techniques including CLEM and cryo-FIB, due to their robustness and similarity to glass surfaces.</li> <li>The production of FIB lamallae is aided by the robustness and resilience of SiO<sub>2</sub>.</li> <li>The ease of functionalization simplifies the attachment of biomolecules (for example DNA or microtubules) for controlled investigations.</li> <li>Semiconductor material characterization can take advantage of all these features.</li> </ul></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-6 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1694625035256" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1694625035256_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h5>Research using QUANTIFOIL<sup>®</sup> SiO<sub>2</sub> films</h5> <p> </p></span></div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-7 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1694690410208" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="hs-tabs"> <ul class="hs-tabs__nav"> <li><a href="#tab-1" class="hs-tabs__navitem hs-tabs__navitem--active"><div id="hs_cos_wrapper_widget_1694690410208_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_text" data-hs-cos-field="tab_label">Methods development</div></a></li><li><a href="#tab-2" class="hs-tabs__navitem"><div id="hs_cos_wrapper_widget_1694690410208_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_text" data-hs-cos-field="tab_label">Recent publications</div></a></li> </ul> <div id="tab-1" class="hs-tabs__item hs-tabs__item--active"><div id="hs_cos_wrapper_widget_1694690410208_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_rich_text" data-hs-cos-field="content"><h5>Methods development for <em>in situ </em>structural investigation by FIB-milling and cryo-electron tomography</h5> <p>Toro-Nahuelpan <em>et al</em>. Tailoring cryo-electron microscopy grids by photo-micropatterning for in-cell structural studies. <a href="https://doi.org/10.1038/s41592-019-0630-5" rel="noopener">Nat Methods 17: 50-54 (2020)</a></p> <p>Lucas and Grigorieff. Quantification of gallium cryo-FIB milling damage in biological lamellae. <a href="https://doi.org/10.1073/pnas.2301852120" rel="noopener" target="_blank">Proc. Natl Acad. Sci. USA 120: e2301852120 (2023)</a></p> <p>Franken et al. Protocol for live-cell fluorescence-guided cryoFIB-milling and electron cryo-tomography of virus-infected cells. <a href="https://doi.org/10.1016/j.xpro.2022.101696" rel="noopener" target="_blank">STAR Protocols 3: 101696 (2022)</a></p> <p> </p></div></div> <div id="tab-2" class="hs-tabs__item"><div id="hs_cos_wrapper_widget_1694690410208_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_rich_text" data-hs-cos-field="content"><h5>Recent examples of Cryo-ET investigations using SiO<sub>2</sub> grids</h5> <p>Shepherd et al. Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines. Proc <a href="https://doi.org/10.1073/pnas.2303567120" rel="noopener" target="_blank">Natl Acad Sci USA 120: e2303567120 (2023)</a></p> <p>Winter et al. The Ebola virus VP40 matrix layer undergoes endosomal disassembly essential for membrane fusion. <a href="https://doi.org/10.15252/embj.2023113578" rel="noopener" target="_blank">EMBO J 42: e113578 (2023)</a></p> <p>Zhang et al. Molecular mechanisms of stress-induced reactivation in mumps virus condensates. <a href="https://doi.org/10.1016/j.cell.2023.03.015" rel="noopener" target="_blank">Cell 186: 1877-1894 (2023)</a></p></div></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div data-global-resource-path="Quantifoil-Theme-2022/templates/partials/footer.html"><footer class="footer"> <div class="container"> <div class="container-fluid footer-inr"> <div class="row-fluid-wrapper"> <div class="row-fluid"> <div class="span12 widget-span widget-type-cell " style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-1 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-2 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div class="ftr-btm-sec d-flex justify-content-between align-items-center"> <ul class="links d-flex"> <li> <a href="https://www.quantifoil.com/privacy"> Privacy Notice & Cookies </a></li> <li> <a href="https://www.quantifoil.com/impressum"> Impressum </a></li> </ul> <span>© 2024 Quantifoil Micro Tools GmbH - part of SPT Labtech</span> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </footer></div>  <script defer src="/hs/hsstatic/content-cwv-embed/static-1.1293/embed.js"></script> <script src="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/template_assets/47339134414/1650468880549/Quantifoil-Theme-2022/js/popper.min.js"></script> <script src="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/template_assets/47339139317/1650468880396/Quantifoil-Theme-2022/js/bootstrap.min.js"></script> <script src="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/template_assets/47339182575/1650468879585/Quantifoil-Theme-2022/js/animation.min.js"></script> <script src="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/template_assets/47338889202/1650468878678/Quantifoil-Theme-2022/js/owl.carousel.min.js"></script> <script src="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/template_assets/47339134413/1650468879439/Quantifoil-Theme-2022/js/mobile-menu.min.js"></script> <script src="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/template_assets/47338889200/1650468883471/Quantifoil-Theme-2022/js/counter.min.js"></script> <script src="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/template_assets/47338889201/1650468878457/Quantifoil-Theme-2022/js/custom.min.js"></script> <script> var hsVars = hsVars || {}; hsVars['language'] = 'en'; </script> <script src="/hs/hsstatic/cos-i18n/static-1.53/bundles/project.js"></script> <script src="https://www.quantifoil.com/hs-fs/hub/25689746/hub_generated/module_assets/47683378661/1649681182058/module_47683378661_Tabber.min.js"></script>  <script type="text/javascript"> var _hsq = _hsq || []; _hsq.push(["setContentType", "standard-page"]); _hsq.push(["setCanonicalUrl", "https:\/\/www.quantifoil.com\/products\/sio2-films"]); _hsq.push(["setPageId", "47362568932"]); _hsq.push(["setContentMetadata", { "contentPageId": 47362568932, "legacyPageId": "47362568932", "contentFolderId": null, "contentGroupId": null, "abTestId": null, "languageVariantId": 47362568932, "languageCode": "en", }]); </script> <script type="text/javascript"> var hbspt = hbspt || {}; (hbspt.targetedContentMetadata = hbspt.targetedContentMetadata || []).push(...[]); var _hsq = _hsq || []; _hsq.push(["setTargetedContentMetadata", hbspt.targetedContentMetadata]); </script> <script type="text/javascript" id="hs-script-loader" async defer src="/hs/scriptloader/25689746.js"></script>  <script type="text/javascript"> var hsVars = { render_id: "d28d1812-a044-4d01-b738-c4de0edaf2d0", ticks: 1732373292895, page_id: 47362568932, content_group_id: 0, portal_id: 25689746, app_hs_base_url: "https://app-eu1.hubspot.com", cp_hs_base_url: "https://cp-eu1.hubspot.com", language: "en", analytics_page_type: "standard-page", scp_content_type: "", analytics_page_id: "47362568932", category_id: 1, folder_id: 0, is_hubspot_user: false } </script> <script defer src="/hs/hsstatic/HubspotToolsMenu/static-1.354/js/index.js"></script> </body></html>

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