CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHdpZHRoPSIzMiIgaGVpZ2h0PSIzMiIgZmlsbD0ibm9uZSI+PHBhdGggZmlsbD0iI0IyMEYwMyIgZD0iTTE2IDNhMTMgMTMgMCAxIDAgMTMgMTNBMTMuMDE1IDEzLjAxNSAwIDAgMCAxNiAzbTAgMjRhMTEgMTEgMCAxIDEgMTEtMTEgMTEuMDEgMTEuMDEgMCAwIDEtMTEgMTEiLz48cGF0aCBmaWxsPSIjQjIwRjAzIiBkPSJNMTcuMDM4IDE4LjYxNUgxNC44N0wxNC41NjMgOS41aDIuNzgzem0tMS4wODQgMS40MjdxLjY2IDAgMS4wNTcuMzg4LjQwNy4zODkuNDA3Ljk5NCAwIC41OTYtLjQwNy45ODQtLjM5Ny4zOS0xLjA1Ny4zODktLjY1IDAtMS4wNTYtLjM4OS0uMzk4LS4zODktLjM5OC0uOTg0IDAtLjU5Ny4zOTgtLjk4NS40MDYtLjM5NyAxLjA1Ni0uMzk3Ii8+PC9zdmc+);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "pubs.acs.org",cType: 'managed',cRay: '9285178e6a30fd26',cH: 'tlEYDkpYLGjmo3kKYSd.9cO4Q4GazJwLwkAb3gGddZI-1743311336-1.2.1.1-JjY7SsWTriZ60y7e7IrQhdk2Ge0RRi.FcO0bZxIjZiuHlWdW7KlQ3tUGVsnPRlwL',cUPMDTk: "\/doi\/abs\/10.1021\/ja00833a048?__cf_chl_tk=qO.yfjvqw_1jTDckAKv6NvUpOPSXCbaBamjUjhTUow0-1743311336-1.0.1.1-MwFKQSWB68NJ8mb7lU2Im9vru.rMngIqkhJmRAq282U",cFPWv: 'b',cITimeS: '1743311336',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/abs\/10.1021\/ja00833a048?__cf_chl_f_tk=qO.yfjvqw_1jTDckAKv6NvUpOPSXCbaBamjUjhTUow0-1743311336-1.0.1.1-MwFKQSWB68NJ8mb7lU2Im9vru.rMngIqkhJmRAq282U",md: "6XNBkAD_QEFwJVH7tFJlz2RtYbC8cov07GBCxQRVh.c-1743311336-1.2.1.1-0.AXSn_9bu_.A3dpOl7pPX8LBAyc0ilsgMHjBRCVHOeXhl3cQ6ta3Xex8eJ8E0h6sAc3qI_VgedovBTVPNf4FRgxEXFJjFdg8HAN1X.lpjYCyVtJ8ruYoZSMJ51HtJFnpZ6HgNi4M0xqeB3C2maxQaUDi19lQ6U1VH_p7TVL.UmQadTzQwoNYVh3gPHzS5hmkYY2iQ7JuO6BLvGesVP82aD2cxmreSKVzNMypywjn6ecERdODBj_3wyfViIpMQYRnGkpdbNJ1hC_dN3Romnf59YelhD7wRlEfkvTxqLxJw_1yqGHHJFGmMxn50tZoJu1C7oIqgeCSuFkNOH1pE7PTMQAX7CKlD0NAre3i6kqLDwBkJftgYVdzkzF0veQF7lRNIL46.DRgpRV6Rr0dKNQIIluUgT9g.ZrprjH8gRO1IuxAUuNH0Igw6fz8b0BhQdCLxod9SIMYwSksGKIDzQ9xXK72.b85ZEgFH.BdE4yCeopThLDB3i82pBh30xTykJ0wCuCvr4Da5j.J1e9RgiEF.vx90_XKEwW2Wy4MGgJKJTxCYAL2w7jPIwlXW5ipNDI1jyNWbgGzVXs2WGkjGoSWdqsiKIp8q3dePAcgubP5tA9JN6fC0wMOHXFzqSM9_GY76GQNOD4AHWPFMrlkuguMOWN7Dm6LP7wjOD.0EjPpWkeQ6tisz2yy7MDdxgsLJhtuckMRj3r44tG85ao8LQkuMnLNZziQ9pDuScKChy1mITs8bWG5FCh3J3nV_x1nBBkfzkejhLSO12idg_35qhC1LIRDtLhovnaPucKxKxRhT9mbq4e3365QPlGpCgr38zja2bnp8O8tOhIXtMXyBauY0p_szixUus8OYtcFKTljwoVVRiJQ15CiiXlrX__z5eav4.xUDvf_fun8gPujJboIuFWjloJk1wc85O3eo8r5UY_dQspQKM64maAsvesW.i_yW2x1H0.5bGTTsass0rT5vs5HRVoZJulAHWsAY5tD60ey4AnLTg6HxXBGcTiZy8JVePEved55H2sVwXrzgD6gKt.3ubilSG.9Mk0_.g4pWm4JFEqbKejScc.lbxB0.WlBsilOWp7_7FEn7edv_uiywj_8r1MANmmiDecnHORfjINmi5RQsrkgzfIJQE9QHY_DTOQ4_JcFYehCoNGZig9O6.GmOFeXNQv4HaUx6V4g9oMAPomrC93pgMdlhCK68f0XhAEn5IAgoJlCOarfHnbijP_qS7THlxJKhA2tUiEDMsBtfWaWGNU9MxPlO9u_yehmr8tp3Ul1jauqGqehZ7q.A",mdrd: "YCkg2YaZa3QrRryUTIHyvdC4Z4vPTBdFmZ4Xou6lRLY-1743311336-1.2.1.1-nQ2FFz9yKfJ0cEaKTS8.3P7SHbKWjQnOFBtR4PbaNdnjAvOA9tgVlXOjSp2UEJiEMdZIXLH9I0fM7cz_Av4vowEcVykMcADgNXZM4_xs128iv.U0oGsTkZNnnc_kYK7WxvyGuwC2tVwaOi7KOhBzioNkTJO0G4g.mfW8AtCX5Vd..ST0MTwwrVv_dttJYKKbnJJTwc5WPmE64Ux2yPUEy_24soLJxTMIJf6kr.wjTJMRq6EcvW.qLjxVmZ.raUQ.wMLgUuq7lRCo2rqIO9xZiHUkfaK2.giwDbcqLAOJTJt6fcA9jULeCYK3xJcyNpRNGAeXAcVSQK5AVmyS.9BmXC8mGYIZ.Me6V3w7MnP.t_AjxUT3FdDxBc92XXYLTl8lnbTR3mnQ8kZvlaraUaUl9xhueSu6npw4szEHnThxJH8PDxmZfLHZIM7nLsn_G9EL749CHLgaAi3QGItZpB0DBtwe7yyoAFoeapwKDHV.MEEZFqNuyEb4zwsrM.3opGmOecJtptzc.pK0MiJgqFGPssqZB0BikEACYy6rcn6Sio.7gzNxfHTSGoApBHufiJLVh9JaQnJhbRKHlbBhjDYt9RPkAOHEGSv.hot2Rq3oySe7.Ovky7Nlsfa08S80mEU8gwZPiwvjJc3HCoPXv3s887izWPIN_On4aLPy2CcU87zNkSG5RyUvFG4XQRRch3LTC6Yv4z66afeDBqMpfN1DD4CMAiReLIMGZspKacCJw35eaNtZ_Ch1VdC6zxDx4E18WaCGVIHc.d1a_dPRJhXhdNZySbb1Vf1_yAUFc_jhmDG.f8gFCovC4o_642_.QV0VXfvfx69qz.Tx_lfBfMpuz5QQNvTiFI5kmWgJ..iylLSAwT7qqQRwyb0cT1s4d.stX_LoXAHOiK_SbtZU0C5AsHexU9Wqiau90npNxlyaYr21cq06EDlRoUhdg1HrtC.sTTNbLghQBwXusETWZF8aYavNXb.uKoB8qGGpOxCX_3w5ppjfnaah3n1bV2_xJfKI8.QN_TXh076rIWs9V6lynATYYRvY1x_VZHYlV43FQ_03Oxs.r9ePxmZkR9TR5vnXAsiZ4EX5w_t0vMlZI4WOb0d0qzB6A9_DkKRJCUMrCmuaXLxnE1SfUWvNOTGeBdnvqWiKSao5ILeWXCz7LYTnhX7CfeCe2yfFZtyiuxYlVnohmI2F.QuyvVLI1pADC_bobPvKMxNMvIh4Wq9_RMnucHszpb98m_wWMpfiJLS.D6ulEVvX5r7sD9e.G__akEe5nFqPbNlyBO6A5Hk2VtBlR7qEcFQ9UYaHpb457rkurtrkvShNwWfeagfQ9wnDxhBC4edB50Oj72p9B4c.D9J1oIyk5ejRr6X08vfLPJfHEQJx4Vwzi5NUkwGvqlvYSD2BNjD6F1rwyy3q4SLY_uZGXMQB4nDKMM0Dw41FIiB99xqZhTQsbDuSwSviIgKNWAB13BvEYcGuE8BW1iz6l371YAuM_IBJtiHJNb2m2nn5EfmkqyQOo.y1pynbcTqbLm_9Fakkvh58Y8ZBxyfbcNinMy2zVPqiJBnkZZl6byuuegGEepke3EnI4svRh7_nkbeHNc6wLGC6cYYFeTvy33731cbCROQEel_g75TPhZVz0KlIZ2cAHoJ36KjEcCjXJylAgMUL9p6BabG1IFwMYmwhXyWzVP0HioJXb9U24QSOcavbbwfA0cuJpi_jIAw4Y_PQMVInNnh.qZ1I2L2ZQ0bW1ECBxZBwewFFi5XKWschZOF7EFycDKnnUhWskPO0trNEaWnIs0ozT19DTr2.cqFAzBBZuuYg6YJDi8_KgZ4np1EEnw4K.6cZhESmxqcY0o2hG0MmnFfT9pBB.WhVDa0ll.aRIrTiLhIcOXjrvDW83fVa16Grv4BHBOLEVyfpDBqH1ywxhVRHloBUhEekb4paW18S3SnjSa9gJRzm5Mr00F1mDDDl_49rCmx.L.h0HDDoCxAWDwZJJeFCSO0nZDpL2X62Y0YV3VPtBL6Bz.CFkbYCtHUSPGovDG1oHld.ljak"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=9285178e6a30fd26';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/abs\/10.1021\/ja00833a048?__cf_chl_rt_tk=qO.yfjvqw_1jTDckAKv6NvUpOPSXCbaBamjUjhTUow0-1743311336-1.0.1.1-MwFKQSWB68NJ8mb7lU2Im9vru.rMngIqkhJmRAq282U" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>