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<!DOCTYPE html><html lang="en-US"><head><meta charSet="utf-8"/><meta name="viewport" content="width=device-width"/><title>Prism Updates - GraphPad</title><meta name="description" content="Discover and download the latest GraphPad Prism releases."/><meta property="og:title" content="Prism Updates - GraphPad"/><meta property="og:description" content="Discover and download the latest GraphPad Prism releases."/><meta property="og:url" content="https://www.graphpad.com/updates"/><link rel="canonical" href="https://www.graphpad.com/updates"/><meta name="next-head-count" content="8"/><script type="text/javascript"> window._vwo_code = window._vwo_code || (function(){ var account_id=587200, settings_tolerance=2000, library_tolerance=2500, use_existing_jquery=false, is_spa=1, hide_element='body', /* DO NOT EDIT BELOW THIS LINE */ f=false,d=document,code={use_existing_jquery:function(){return use_existing_jquery;},library_tolerance:function(){return 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class="cell shrink"><div class="topbar-block-link-icon"><i class="wrapper-icon wrapper-icon-link-ext wrapper-icon--s"></i></div></div></div><p class="text-xs text-color-white">Statistical analysis and graphing software for scientists</p></a></div><div class="cell small-12 medium-4 large-3"><a href="//www.geneious.com/?utm_medium=referral&utm_source=graphpad&utm_campaign=dotmatics-top-bar" target="_blank" class="link topbar-block-link"><div class="grid-x"><div class="cell auto"><img class="image" alt="" src="https://cdn.graphpad.com/assets/17.16.6/assets/images/dotmatics/lab-archives/top-bar/PreNav-Logo-Geneious.svg"/></div><div class="cell shrink"><div class="topbar-block-link-icon"><i class="wrapper-icon wrapper-icon-link-ext wrapper-icon--s"></i></div></div></div><p class="text-xs text-color-white">Bioinformatics, cloning, and antibody discovery software</p></a></div><div class="cell small-12 medium-4 large-3"><a href="//www.snapgene.com/?utm_medium=referral&utm_source=graphpad&utm_campaign=dotmatics-top-bar" target="_blank" class="link topbar-block-link"><div class="grid-x"><div class="cell auto"><img class="image" alt="" src="https://cdn.graphpad.com/assets/17.16.6/assets/images/dotmatics/lab-archives/top-bar/PreNav-Logo-SnapGene.svg"/></div><div class="cell shrink"><div class="topbar-block-link-icon"><i class="wrapper-icon wrapper-icon-link-ext wrapper-icon--s"></i></div></div></div><p class="text-xs text-color-white">Plan, visualize, & document core molecular biology procedures</p></a></div><div class="cell small-12 medium-4 large-3"><a href="//www.labarchives.com/?utm_medium=referral&utm_source=graphpad&utm_campaign=dotmatics-top-bar" target="_blank" class="link topbar-block-link"><div class="grid-x"><div class="cell auto"><img class="image" alt="" src="https://cdn.graphpad.com/assets/17.16.6/assets/images/dotmatics/lab-archives/top-bar/PreNav-Logo-LabArchives.svg"/></div><div class="cell shrink"><div class="topbar-block-link-icon"><i class="wrapper-icon wrapper-icon-link-ext wrapper-icon--s"></i></div></div></div><p class="text-xs text-color-white">Electronic Lab Notebook to organize, search and share data</p></a></div><div class="cell small-12 medium-4 large-3"><a href="//proteinmetrics.com/?utm_medium=referral&utm_source=graphpad&utm_campaign=dotmatics-top-bar" target="_blank" class="link topbar-block-link"><div class="grid-x"><div class="cell auto"><img class="image" alt="" src="https://cdn.graphpad.com/assets/17.16.6/assets/images/dotmatics/lab-archives/top-bar/PreNav-Logo-Protein-Metrics.svg"/></div><div class="cell shrink"><div class="topbar-block-link-icon"><i class="wrapper-icon wrapper-icon-link-ext wrapper-icon--s"></i></div></div></div><p class="text-xs text-color-white">Proteomics software for analysis of mass spec data</p></a></div><div class="cell small-12 medium-4 large-3"><a href="//www.omiq.ai/?utm_medium=referral&utm_source=graphpad&utm_campaign=dotmatics-top-bar" target="_blank" class="link topbar-block-link"><div class="grid-x"><div class="cell auto"><img class="image" alt="" src="https://cdn.graphpad.com/assets/17.16.6/assets/images/dotmatics/lab-archives/top-bar/PreNav-Logo-OMIQ.svg"/></div><div class="cell shrink"><div class="topbar-block-link-icon"><i class="wrapper-icon wrapper-icon-link-ext wrapper-icon--s"></i></div></div></div><p class="text-xs text-color-white">Modern cytometry analysis platform</p></a></div><div class="cell small-12 medium-4 large-3"><a href="//denovosoftware.com/?utm_medium=referral&utm_source=graphpad&utm_campaign=dotmatics-top-bar" target="_blank" class="link topbar-block-link"><div class="grid-x"><div class="cell auto"><img class="image" alt="" src="https://cdn.graphpad.com/assets/17.16.6/assets/images/dotmatics/lab-archives/top-bar/PreNav-Logo-FCS-Express.svg"/></div><div class="cell shrink"><div 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target="_blank">Explore the Applications<i class="wrapper-icon wrapper-icon-link-ext ml-4"></i></a></div></div></div></span></span></div></div></div></div></section><header class="header" role="banner"><div class="grid-container"><div class="grid-x grid-padding-x header__layout navbar"><div class="cell"><div class="grid-x align-items-center"><div class="cell large-shrink navbar__header"><div class="display-flex justify-content-between align-items-center"><div class="header__logo"><a href="//www.graphpad.com/" data-qa-selector="header-logo" class="link--external logo-link max-w-45"><img class="image logo" alt="GraphPad by Dotmatics" src="https://cdn.graphpad.com/assets/17.16.6/assets/images/graphpad/logo/logo-graphpad-white.svg"/></a></div><button type="button" class="navbar__toggle" data-toggle="toggleButton" data-target="#navbar"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="cell large-auto navbar__collapse" id="navbar"><div class="display-flex--lg justify-content-end--lg w-full--lg"><ul class="nav primary-nav nav--inverted"><li class="dropdown dropdown--mega-menu"><span class="dropdown-title nav__item-link"><span class=""><span class="dropdown-title__text">Prism</span><span class="dropdown-title__triangle"><i class="wrapper-icon wrapper-icon-angle-down m-0"></i></span></span></span><span class="dropdown-body dropdown-body--align-left bg-color-white"><div class="grid-container"><div class="grid-x grid-margin-x grid-margin-y justify-content-center py-3"><div class="cell small-12 medium-4 large-3 border-right-1px-black--20--lg"><p class="text-s text-color-black--60 pl-1">FEATURES</p><div class="my-0--sm my-0--md my-3--lg"><div class=""><a href="/features" class="text-color-black text-color-2--hover text-weight--400 pl-1 pb-0--sm pb-0--md nav__item-link">Prism Overview</a></div><div class="text-s text-color-black--46 mt-0 pl-1">Analyze, graph and present your work</div></div><div class="my-0--sm my-0--md my-3--lg"><div class=""><a href="/features#analysis" class="text-color-black text-color-2--hover text-weight--400 pl-1 pb-0--sm pb-0--md nav__item-link">Analysis</a></div><div class="text-s text-color-black--46 mt-0 pl-1">Comprehensive analysis and statistics</div></div><div class="my-0--sm my-0--md my-3--lg"><div class=""><a href="/features#graphing" class="text-color-black text-color-2--hover text-weight--400 pl-1 pb-0--sm pb-0--md nav__item-link">Graphing</a></div><div class="text-s text-color-black--46 mt-0 pl-1">Elegant graphing and visualizations</div></div><div class="my-0--sm my-0--md my-3--lg"><div class=""><a href="/cloud" class="text-color-black text-color-2--hover text-weight--400 pl-1 pb-0--sm pb-0--md nav__item-link">Cloud</a></div><div class="text-s text-color-black--46 mt-0 pl-1">Share, view and discuss your projects</div></div><div class="my-0--sm my-0--md my-3--lg"><div class=""><a href="/updates" class="text-color-black text-color-2--hover 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class=""><a href="/features/prism-nonlinear-regression" class="text-color-black text-color-2--hover text-weight--400 pl-1 pb-0--sm pb-0--md nav__item-link">Non-Linear Regression</a></div></div><div class="my-0--sm my-0--md my-3--lg"><div class=""><a href="/features/machine-learning" class="text-color-black text-color-2--hover text-weight--400 pl-1 pb-0--sm pb-0--md nav__item-link">Machine Learning</a></div></div><div class="my-0--sm my-0--md my-3--lg"><div class=""><a href="/features/flow-cytometry" class="text-color-black text-color-2--hover text-weight--400 pl-1 pb-0--sm pb-0--md nav__item-link">Flow Cytometry</a></div></div></div><div class="cell small-12 medium-4 large-3"><p class="text-s text-color-black--60 pl-1">INTEGRATIONS</p><div class="my-0--sm my-0--md my-3--lg"><div class=""><a href="/integrations/omiq" class="text-color-black text-color-2--hover text-weight--400 pl-1 pb-0--sm pb-0--md nav__item-link">OMIQ Flow Cytometry</a></div></div><div class="my-0--sm my-0--md my-3--lg"><div class=""><a href="/integrations/fcs-express" class="text-color-black text-color-2--hover text-weight--400 pl-1 pb-0--sm pb-0--md nav__item-link">FCS Express</a></div></div><div class="my-0--sm my-0--md my-3--lg"><div class=""><a href="/integrations/labarchives" class="text-color-black text-color-2--hover text-weight--400 pl-1 pb-0--sm pb-0--md nav__item-link">LabArchives</a></div></div></div></div></div></span></li><li class=""><a href="/enterprise" class="link nav__item-link">Enterprise</a></li><li class=""><a href="/resources" class="link nav__item-link">Resources</a></li><li class=""><a href="//www.graphpad.com/support/" class="nav__item-link">Support</a></li><li class=""><a href="//www.graphpad.com/how-to-buy/" class="nav__item-link">Pricing</a></li></ul><ul class="nav secondary-nav nav--inverted"><li class="secondary-nav__item"><a href="//www.graphpad.com/ecommerce/" class="nav__item-link"><i class="wrapper-icon wrapper-icon-shopping-cart"></i>Cart</a></li><li 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wrapper-icon-arrow-to-bottom"></i> Free Trial</a></li></ul></div></div></div></div></div></div></header><main><div class="" role="main"><section class="section-hero section-hero-text-center section-hero-color-1"><div class="grid-container"><div class="grid-x"><div class="cell"><div class="grid-x grid-margin-x grid-margin-y justify-content-center"><div class="cell medium-shrink"><h1 class="heading section-hero__title">Prism Updates</h1><p class="text-xl section-hero__lead">The latest Prism version is 10.4.0 (Windows and Mac).</p></div></div><div class="grid-x grid-margin-x grid-margin-y justify-content-center"><div class="cell small-12 medium-8 text-center"><div class="line line--opacity-20 mt-6 mb-8"></div><h2 class="heading heading-l text-color-white">How to Update to Prism 10</h2><p class="text-l text-weight--medium">Subscribers</p><p class="text-l text-color-white--80">Update for free by downloading the installer for your system (<a href="/support/faq/which-are-the-current-versions-of-prism-how-can-i-update-or-upgrade/" class="link text-color-4 text-color-white--hover">instructions</a>):</p><p class="text-l text-center my-0"><a href="https://cdn.graphpad.com/downloads/prism/10/InstallPrism10.msi" class="link text-color-4 text-color-white--hover">Windows</a><span class="section-hero__vertical_delimiter">|</span><a href="https://cdn.graphpad.com/downloads/prism/10/InstallPrism10.dmg" class="link text-color-4 text-color-white--hover">Mac</a></p></div></div><div class="grid-x grid-margin-x grid-margin-y justify-content-center"><div class="cell small-12 medium-8 text-center"><p class="text-l text-weight--medium">Perpetual Customers</p><p class="text-l text-color-white--80">Contact us at <a href="/go/contact-support/" class="link text-color-4 text-color-white--hover">help.graphpad.com</a> to learn about upgrade options.</p></div></div></div></div></div></section><section class="updates-page-template"><div class="grid-container"><div class="grid-x grid-padding-x justify-content-center"><div class="cell small-12 medium-11 large-8"><h2 class="heading updates-page-template__title">Latest Prism Releases</h2><div class="updates-page-template__list"><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-10-4-0-release-notes" class="link updates-page-template__list-item-title-link">Prism 10.4.0</a></div><div class="updates-page-template__list-item-date">October 29, 2024</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph"><b>What's New in Prism 10.4.0!</b></p><ul class="ul ul-default post-element__ul"><li class="li post-element__list-item"><b>New nonlinear dose-response models</b>: Gaddum-Schild competitive inhibition binding models for nonlinear regression</li><li class="li post-element__list-item"><b>More intuitive controls for multiple variable heat maps</b>: improved axis controls to customize heat maps generated from multiple variables data.</li><li class="li post-element__list-item"><b>Dotmatics Luma integration</b>: seamlessly connect your Prism projects and data with Dotmatics Luma - the scientific data management platform that seamlessly centralizes and optimizes your data lifecycle to handle both the volume and complexity of your scientific data in one place</li><li class="li post-element__list-item">Improved file auto-recovery to increase Prism's ability to restore previously corrupted project files</li><li class="li post-element__list-item">Performance and stability improvements throughout the application</li></ul><p class="post-element__paragraph"></p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-10-4-0-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-10-3-1-release-notes" class="link updates-page-template__list-item-title-link">Prism 10.3.1</a></div><div class="updates-page-template__list-item-date">August 28, 2024</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph">This release fixes multiple issues present in Prism versions 10.3.0, including a fix for an issue that could lead to a crash while performing unpaired t tests, and a fix for an issue that could cause some results of nonlinear regression to be incorrectly reported as blank</p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-10-3-1-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-10-3-0-release-notes" class="link updates-page-template__list-item-title-link">Prism 10.3.0</a></div><div class="updates-page-template__list-item-date">July 31, 2024</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph"><b>What's New in Prism 10.3.0!</b></p><ul class="ul ul-default post-element__ul"><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-10-3-0-release-notes#U2FtcGxlJTIwU2l6ZSUyMGFuZCUyMFBvd2VyJTIwQW5hbHlzaXM" class="link">Sample size and power analysis</a>: quickly determine the number of samples or subjects that you need for your experimental design; explore the relationships between sample size and power; investigate the smallest detectable effect size when working with a limited number of samples or subjects.</li><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-10-3-0-release-notes#SGllcmFyY2hpY2FsJTIwQ2x1c3RlcmluZw" class="link">Hierarchical clustering</a>: uncover the natural connections between observations in your data. This machine learning technique allows you to investigate how closely different observations are related to each other and uncover groupings within your data.</li><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-10-3-0-release-notes#Sy1tZWFucyUyMENsdXN0ZXJpbmc" class="link">K-means clustering</a>: specify a target number of clusters, and this machine learning algorithm will partition your data, iteratively grouping the most similar observations together and adjusting cluster assignments.</li><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-10-3-0-release-notes#RGVuZHJvZ3JhbXM" class="link">Dendrograms</a>: visualize the hierarchical relationships from clustering analyses. Use dendrograms as an independent graph or as part of a heatmap from the output of hierarchical clustering.</li><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-10-3-0-release-notes#Q29uZmlkZW5jZSUyMEVsbGlwc2VzJTIwYW5kJTIwQ29udmV4JTIwSHVsbHM" class="link">Confidence ellipses and convex hulls</a>: visually represent estimates for the parameters that define the population from which your data were drawn, or clearly indicate the boundaries for groups of data on your graphs.</li><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-10-3-0-release-notes#VGVYLXJlbmRlcmVkJTIwZXF1YXRpb25z" class="link">TeX-rendered equations for nonlinear regression</a>: add high-quality, formatted equations from nonlinear regression onto your graphs. Insert formulas that include best-fit parameter values directly beside your graphed curves.</li></ul><p class="post-element__paragraph"></p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-10-3-0-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-10-2-3-release-notes" class="link updates-page-template__list-item-title-link">Prism 10.2.3</a></div><div class="updates-page-template__list-item-date">April 30, 2024</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph">This release fixes multiple issues present in Prism versions 10.2.0-10.2.2, including an issue in which a file corruption may occur if the system folder that Prism uses as its working directory is write-protected.</p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-10-2-3-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-10-2-2-release-notes" class="link updates-page-template__list-item-title-link">Prism 10.2.2</a></div><div class="updates-page-template__list-item-date">March 26, 2024</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph">This release fixes multiple issues present in Prism version 10.2.0 and 10.2.1, including an update for a broken link to Prism Academy in the Welcome dialog, linear regression fixes, and improvements to data linking on graphs.</p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-10-2-2-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-10-2-1-release-notes" class="link updates-page-template__list-item-title-link">Prism 10.2.1</a></div><div class="updates-page-template__list-item-date">March 06, 2024</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph">This release fixes multiple issues present in Prism version 10.2.0, including a number of crashes related to issues present in the recalculation of nonlinear regression.</p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-10-2-1-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-10-2-0-release-notes" class="link updates-page-template__list-item-title-link">Prism 10.2.0</a></div><div class="updates-page-template__list-item-date">February 08, 2024</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph"><b>What's New in Prism 10.2.0!</b></p><div class="image-caption image-caption--block post-element__image"><picture class="picture"><source media="(max-width: 428px)" srcSet="https://images.ctfassets.net/gyag548snr3z/VeW6Idtozs3wUqGdZ8DuR/962596eb2cc9cc63c3c785b7e97f20b8/Dark_Dialogs.png?w=408 1x, https://images.ctfassets.net/gyag548snr3z/VeW6Idtozs3wUqGdZ8DuR/962596eb2cc9cc63c3c785b7e97f20b8/Dark_Dialogs.png?w=816 2x"/><source media="(min-width: 429px) and (max-width: 639px)" srcSet="https://images.ctfassets.net/gyag548snr3z/VeW6Idtozs3wUqGdZ8DuR/962596eb2cc9cc63c3c785b7e97f20b8/Dark_Dialogs.png?w=619 1x, https://images.ctfassets.net/gyag548snr3z/VeW6Idtozs3wUqGdZ8DuR/962596eb2cc9cc63c3c785b7e97f20b8/Dark_Dialogs.png?w=1238 2x"/><source media="(min-width: 640px) and (max-width: 767px)" srcSet="https://images.ctfassets.net/gyag548snr3z/VeW6Idtozs3wUqGdZ8DuR/962596eb2cc9cc63c3c785b7e97f20b8/Dark_Dialogs.png?w=482 1x, https://images.ctfassets.net/gyag548snr3z/VeW6Idtozs3wUqGdZ8DuR/962596eb2cc9cc63c3c785b7e97f20b8/Dark_Dialogs.png?w=964 2x"/><source media="(min-width: 768px) and (max-width: 1023px)" srcSet="https://images.ctfassets.net/gyag548snr3z/VeW6Idtozs3wUqGdZ8DuR/962596eb2cc9cc63c3c785b7e97f20b8/Dark_Dialogs.png?w=652 1x, https://images.ctfassets.net/gyag548snr3z/VeW6Idtozs3wUqGdZ8DuR/962596eb2cc9cc63c3c785b7e97f20b8/Dark_Dialogs.png?w=1304 2x"/><source media="(min-width: 1025px)" srcSet="https://images.ctfassets.net/gyag548snr3z/VeW6Idtozs3wUqGdZ8DuR/962596eb2cc9cc63c3c785b7e97f20b8/Dark_Dialogs.png?w=770 1x, https://images.ctfassets.net/gyag548snr3z/VeW6Idtozs3wUqGdZ8DuR/962596eb2cc9cc63c3c785b7e97f20b8/Dark_Dialogs.png?w=1540 2x"/><img class="image" alt="" loading="lazy" decoding="async" src="//images.ctfassets.net/gyag548snr3z/VeW6Idtozs3wUqGdZ8DuR/962596eb2cc9cc63c3c785b7e97f20b8/Dark_Dialogs.png"/></picture></div><ul class="ul ul-default post-element__ul"><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-10-2-0-release-notes#RGFyayUyME1vZGUlMjBmb3IlMjBtYWNPUw" class="link">Dark mode for macOS</a>: Prism will now adopt your system settings for Dark Mode with re-designed dialogs, toolbars, and table elements in a stylish dark theme</li><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-10-2-0-release-notes#Q29tcGFjdCUyMExldHRlciUyMERpc3BsYXk" class="link">Compact Letter Display</a>: reduce the clutter on your graphs while presenting your pairwise comparisons from one-way and two-way ANOVA by using letters instead of asterisks to indicate groups with statistically significant differences</li><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-10-2-0-release-notes#UmUtZGVzaWduZWQlMjBDb2xvciUyMFNjaGVtZSUyME1lbnVz" class="link">Re-designed Color Scheme menu</a>: view the colors for each color scheme directly in the menu, quickly access recently used color schemes, and browse your own user-defined color schemes</li><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-10-2-0-release-notes#VXBkYXRlZCUyMFByaXNtJTIwQ2xvdWQlMjBDb250cm9scw" class="link">New Prism Cloud controls</a>: quickly get signed in to your Prism Cloud account and start publishing your work with simplified and more intuitive controls</li></ul><p class="post-element__paragraph"></p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-10-2-0-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-10-1-2-release-notes" class="link updates-page-template__list-item-title-link">Prism 10.1.2</a></div><div class="updates-page-template__list-item-date">December 14, 2023</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph">This Windows-only release of Prism fixes an issue that began occurring after a recent Windows update and resulted in an error when trying to open embedded (OLE) Prism objects in Microsoft Office applications.</p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-10-1-2-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-10-1-1-release-notes" class="link updates-page-template__list-item-title-link">Prism 10.1.1</a></div><div class="updates-page-template__list-item-date">November 28, 2023</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph">This release fixes multiple issues present in version 10.1.0, including a known issue that could lead to data loss within existing Prism files.</p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-10-1-1-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-1010-release-notes" class="link updates-page-template__list-item-title-link">Prism 10.1.0</a></div><div class="updates-page-template__list-item-date">October 19, 2023</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph"><b>New in Prism 10.1.0! </b>Fine-tune the appearance of your Multiple Variables graphs with much-needed improvements to symbol size options; Take control of your data simulation and allow others to reproduce your work with the ability to specify a random seed; Get your work done faster with improvements to both the performance and the accuracy of numerous analyses throughout Prism.</p><p class="post-element__paragraph">Prism 10.1.0 also introduces numerous bug fixes as well as improvements to Prism Cloud. See <a href="https://www.graphpad.com/updates/prism-1010-release-notes" class="link">full release notes</a> for details.</p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-1010-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-1003-release-notes" class="link updates-page-template__list-item-title-link">Prism 10.0.3</a></div><div class="updates-page-template__list-item-date">September 27, 2023</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph">This release improves the overall performance of Prism 10 and generally reduces the size of .prism files compared to earlier versions of Prism 10.</p><p class="post-element__paragraph">This update also fixes a critical issue with macOS 14 Sonoma, and fixes multiple issues present in Prism 10.0.2.</p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-1003-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-1002-release-notes" class="link updates-page-template__list-item-title-link">Prism 10.0.2</a></div><div class="updates-page-template__list-item-date">August 09, 2023</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph">This release fixes multiple issues present in Prism 10.0.1.</p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-1002-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-1001-release-notes" class="link updates-page-template__list-item-title-link">Prism 10.0.1</a></div><div class="updates-page-template__list-item-date">July 27, 2023</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph">This release fixes multiple issues present in Prism 10.0.0.</p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-1001-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-1000-release-notes" class="link updates-page-template__list-item-title-link">Prism 10.0.0</a></div><div class="updates-page-template__list-item-date">July 11, 2023</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph"><i><b>Powerful data analysis. Advanced graph customization. Simplified collaboration </b></i></p><div class="post-element__video"><div class="wistia-video-container"><div class="wistia_embed wistia_async_k3k0jqv88b wistia-block-detail__embed videoFoam=true"></div></div><div class="post-element__video-caption">Powerful data analysis. Advanced graph customization. Simplified collaboration</div></div><p class="post-element__paragraph"><i><b></b></i></p><ul class="ul ul-default post-element__ul"><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-1000-release-notes#QSUyMG1vcmUlMjBvcGVuJTIwZmlsZSUyMGZvcm1hdA" class="link"><b>Break down data silos:</b></a><b> </b>Introducing a more open file format that enables new workflows and integrations</li><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-1000-release-notes#QSUyMHJlc3BvbnNpdmUlMjBQJTIwdmFsdWUlMjBzdW1tYXJ5JTIwbWV0aG9k" class="link"><b>Simplified interpretation of results:</b></a><b> </b>A new responsive “One or None” P value summary style</li><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-1000-release-notes#TmV3JTIwb3B0aW9ucyUyMGZvciUyMHR3by13YXklMjBBTk9WQSUyMG11bHRpcGxlJTIwY29tcGFyaXNvbnM" class="link"><b>More comprehensive analysis:</b></a><b> </b>Default multiple comparison method for two-way ANOVA</li><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-1000-release-notes#TmV3JTIwdG9vbHMlMjBmb3IlMjBncmFwaCUyMGN1c3RvbWl6YXRpb24lMjBhbmQlMjBkYXRhJTIwZXhwbG9yYXRpb24" class="link"><b>Graph Inspector:</b></a><b> </b>A new interactive approach to multiple variable graph customization</li><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-1000-release-notes#QWNjZXNzJTIwbW9yZSUyMGRhdGElMjB0aGFuJTIwZXZlciUyMGJlZm9yZQ" class="link"><b>Expanded data capabilities:</b></a> Faster performance and support for larger data sets</li><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-1000-release-notes#V3JhbmdsZSUyMHlvdXIlMjBkYXRhJTIwd2l0aCUyMGFsbCUyMG5ldyUyMHRvb2xz" class="link"><b>Wrangle your data with new tools:</b></a> New functions, new syntax, new outputs, and much more</li><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-1000-release-notes#QWNjZXNzJTIwbW9yZSUyMHJlc3VsdHMlMjB0aGFuJTIwZXZlciUyMGJlZm9yZQ" class="link"><b>Access more results:</b></a> An all-new analysis constant dialog</li><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-1000-release-notes#UHJpc20lMjBDbG91ZCUyMEJldGE6JTIwQ29sbGFib3JhdGlvbiUyMG1hZGUlMjBzaW1wbGU" class="link"><b>Collaboration simplified:</b></a> Publish, share, and discuss your work with Prism Cloud beta</li><li class="li post-element__list-item"><a href="https://www.graphpad.com/updates/prism-1000-release-notes#RW5oYW5jZWQlMjBGZWF0dXJlcyUyMGFuZCUyMEltcHJvdmVtZW50cw" class="link"><b>And much, much more!</b></a></li></ul><p class="post-element__paragraph"></p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-1000-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-951-release-notes" class="link updates-page-template__list-item-title-link">Prism 9.5.1</a></div><div class="updates-page-template__list-item-date">February 08, 2023</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph">This release fixes multiple issues in Prism 9.5.0.</p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-951-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-950-release-notes" class="link updates-page-template__list-item-title-link">Prism 9.5.0</a></div><div class="updates-page-template__list-item-date">December 07, 2022</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph"><b>A whole new set of color schemes and introducing the Prism Cloud Early Access Program:</b> creating the perfect visualization is important! You've already gone through all the work of generating and analyzing your data, the last thing you want is an uninteresting looking graph. Adding a bit of color is always a great way to highlight your work, so we've added <i>nine</i> new built-in color schemes to choose from to get the look of your graph just the way you want it.</p><p class="post-element__paragraph">Prism 9.5.0 also introduces the Prism Cloud Early Access program, allowing you to sign up to test the newest, easiest way to view, share, and collaborate on your Prism work with other members of your team (even if they don't use Prism!).</p><p class="post-element__paragraph"></p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-950-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-941-release-notes" class="link updates-page-template__list-item-title-link">Prism 9.4.1</a></div><div class="updates-page-template__list-item-date">July 27, 2022</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph">This release fixes multiple issues in Prism 9.4.0.</p><p class="post-element__paragraph"></p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-941-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-940-release-notes" class="link updates-page-template__list-item-title-link">Prism 9.4.0</a></div><div class="updates-page-template__list-item-date">June 08, 2022</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph"><b>Introducing major improvements to Pairwise Comparisons (Stars on Graph):</b> the pairwise comparisons (automatic stars on graph) feature now supports the Multiple t tests (and nonparametric tests) analysis. Additionally, numerous options for customizing the appearance of the pairwise comparisons on the graph have been introduced, including:</p><ul class="ul ul-default post-element__ul"><li class="li post-element__list-item">P value prefixes. Choose from the default "P = " or "p = " prefixes or add your own</li><li class="li post-element__list-item">Improved bracket style options. Choosing between the three different visual styles is now much clearer</li><li class="li post-element__list-item">Separate controls for text and asterisk size. Make your text bigger, make your asterisks smaller, customize as much as you like</li><li class="li post-element__list-item">Controls for specifying the distance between the text/asterisk and the line/bracket.</li></ul><p class="post-element__paragraph">And many more improvements from earlier versions of Prism!</p><p class="post-element__paragraph"></p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-940-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-931-release-notes" class="link updates-page-template__list-item-title-link">Prism 9.3.1</a></div><div class="updates-page-template__list-item-date">December 15, 2021</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph">This release fixes multiple issues in Prism 9.3.0.</p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-931-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div><div class="updates-page-template__list-item"><div class="updates-page-template__list-item-title"><a href="/updates/prism-930-release-notes" class="link updates-page-template__list-item-title-link">Prism 9.3.0</a></div><div class="updates-page-template__list-item-date">November 15, 2021</div><div class="updates-page-template__list-item-description"><p class="post-element__paragraph"><b>Introducing Cox Proportional Hazards Regression:</b> perform survival analysis while including any number of continuous or categorical predictor variables. Other new features include:</p><ul class="ul ul-default post-element__ul"><li class="li post-element__list-item">New Welcome Dialog pages to help you get started. Watch videos in Prism Academy or read through selections from the Prism guides</li><li class="li post-element__list-item">New and updated keyboard shortcuts to improve your workflow efficiency</li><li class="li post-element__list-item">Support for Windows 11 and macOS 12 Monterey</li><li class="li post-element__list-item">And many more enhancements</li></ul><p class="post-element__paragraph"></p></div><div class="updates-page-template__list-item-action"><a href="/updates/prism-930-release-notes" class="link updates-page-template__list-item-action-link">Details ›</a></div></div></div><div class="updates-page-template__pagination"><div class="pagination pagination--center"><button type="button" disabled="" class="link pagination__item pagination__item--active">1</button><button type="button" class="link pagination__item">2</button><button type="button" class="link pagination__item">3</button><button type="button" class="link pagination__item">Next <i class="wrapper-icon 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Fixed the issue when unfrozen graphs generated by 'Principal Component Analysis' or 'Cox proportional hazards regression' analyses appeared empty if previously the results sheet was deleted and 'Undo' operation was performed.","marks":[],"data":{}}]}]},{"nodeType":"list-item","data":{},"content":[{"nodeType":"paragraph","data":{},"content":[{"nodeType":"text","value":"(Windows) Fixed the issue when Wingding symbols were replaced with squares in a text object pasted to graph sheet with a multiple variables graph copied from any other graph.","marks":[],"data":{}}]}]},{"nodeType":"list-item","data":{},"content":[{"nodeType":"paragraph","data":{},"content":[{"nodeType":"text","value":"(Windows) Fixed the issue when the 'Decimals' option for regular axis ticks could not be applied when 'Number Format' was set to 'Antilog' in the 'Format Axes' 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And we've delivered on a lot of these requests. The Format Pairwise Comparisons dialog has been updated and improved to make it easier to get the visual representation of your analysis results that you want, and to customize its appearance even more.","nodeType":"text"}],"nodeType":"paragraph"},{"data":{},"content":[{"data":{},"marks":[{"type":"bold"}],"value":"P value prefixes","nodeType":"text"}],"nodeType":"paragraph"},{"data":{},"content":[{"data":{},"marks":[],"value":"When adding Pairwise Comparisons, one of the first choices to make is whether to show numeric P values or the associated P value summaries (\"ns\" or asterisks that categorize the numeric P values). Choosing to display numeric P values is often more informative that simply including the corresponding summaries. However, simply adding the appropriate number above the bracket on the graph wasn't always very visually appealing. As a result, we added the option to include prefixes in the bracket labels when displaying numeric P values. You can choose from the built-in \"P =\" or \"p =\" prefixes (depending on your style preference), or enter your own custom prefix. Note that Prism will be smart about how it handles the equals sign at the end of a prefix. If the prefix is \"P =\" (for example), and the numeric P value is reported as \"\u003c0.0001\", Prism will automatically drop the equals sign so that the bracket label is displayed as \"P \u003c 0.0001\"","nodeType":"text"}],"nodeType":"paragraph"},{"data":{},"content":[{"data":{},"marks":[{"type":"bold"}],"value":"Clear bracket style options","nodeType":"text"}],"nodeType":"paragraph"},{"data":{},"content":[{"data":{},"marks":[],"value":"In previous versions of Prism, the three bracket styles offered in the Pairwise Comparisons dialog were displayed in a dropdown menu, and not easy to identify. 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In general, we always recommend showing the underlying data (individual data points) when it's possible as this provides a much better depiction of how the data are distributed compared to a bar that ","nodeType":"text"},{"data":{},"marks":[{"type":"italic"}],"value":"only","nodeType":"text"},{"data":{},"marks":[],"value":" displays the mean or median of the underlying data. However, any time bars are used on a graph, it's a good idea to make sure that the baseline for the bars is zero. This ensures that the height of the bar is proportionate to the value that it represents (the mean or median of the underlying data).","nodeType":"text"}],"nodeType":"paragraph"},{"data":{},"content":[{"data":{},"marks":[],"value":"In previous versions of Prism, the default appearance for the \"Scatter plot with bar\" graph type didn't rely on this rule of setting the bar baseline to zero. 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In the biological sciences, the \"event\" being studied is often death (of animals in a given experimental group, of humans with a particular disease process, etc.), giving this analysis its name. For a long time, Prism has offered a very simple form of survival analysis that uses the Kaplan-Meier estimation of survival. However, this technique is limited to creating survival curves for populations that are assumed to be homogeneous, and this method does not incorporate values for predictor variables that may have been collected for the individuals in the study (such as age, race, treatment group, etc.). Although survival curves generated using the Kaplan-Meier method for different groups (i.e. a \"Treatment\" group and a \"Control\" group) can be statistically compared, there's no way to include continuous predictor variables (such as age, blood pressure, weight, etc.) into these estimations.","nodeType":"text"}],"nodeType":"paragraph"},{"data":{},"content":[{"data":{},"marks":[],"value":"Cox proportional hazards regression (or just Cox regression) is an advanced statistical method of survival analysis that allows for the incorporation of any number of predictor variables (both categorical and continuous predictor variables) into the model. Using all of the information collected for all of the individuals (in all of the different possible groups), Cox regression is able to generate survival estimates for any individual or group with any combination of predictor variable values. 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