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overflow: hidden; text-overflow: ellipsis; -webkit-line-clamp: 3; -webkit-box-orient: vertical; }</style><div class="col-xs-12 clearfix"><div class="u-floatLeft"><h1 class="PageHeader-title u-m0x u-fs30">Biomarkers</h1><div class="u-tcGrayDark">12,221 Followers</div><div class="u-tcGrayDark u-mt2x">Recent papers in <b>Biomarkers</b></div></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline u-displayFlex"><li class="active"><a href="https://www.academia.edu/Documents/in/Biomarkers">Top Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Biomarkers/MostCited">Most Cited Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Biomarkers/MostDownloaded">Most Downloaded Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Biomarkers/MostRecent">Newest Papers</a></li><li><a class="" href="https://www.academia.edu/People/Biomarkers">People</a></li></ul></div><style type="text/css">ul.nav{flex-direction:row}@media(max-width: 567px){ul.nav{flex-direction:column}.TabbedNavigation li{max-width:100%}.TabbedNavigation li.active{background-color:var(--background-grey, #dddde2)}.TabbedNavigation li.active:before,.TabbedNavigation li.active:after{display:none}}</style></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_59714003" data-work_id="59714003" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/59714003/Metabolomic_Characterizations_of_Liver_Injury_Caused_by_Acute_Arsenic_Toxicity_in_Zebrafish">Metabolomic Characterizations of Liver Injury Caused by Acute Arsenic Toxicity in Zebrafish</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Arsenic is one of the most common metalloid contaminants in groundwater and it has both acute and chronic toxicity affecting multiple organs. Details of the mechanism of arsenic toxicity are still lacking and profile studies at metabolic... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_59714003" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Arsenic is one of the most common metalloid contaminants in groundwater and it has both acute and chronic toxicity affecting multiple organs. Details of the mechanism of arsenic toxicity are still lacking and profile studies at metabolic level are very limited. Using gas chromatography coupled with mass spectroscopy (GC/MS), we first generated metabolomic profiles from the livers of arsenic-treated zebrafish and identified 34 significantly altered metabolite peaks as potential markers, including four prominent ones: cholic acid, glycylglycine, glycine and hypotaurine. Combined results from GC/MS, histological examination and pathway analyses suggested a series of alterations, including apoptosis, glycogenolysis, changes in amino acid metabolism and fatty acid composition, accumulation of bile acids and fats, and disturbance in glycolysis related energy metabolism. The alterations in glycolysis partially resemble Warburg effect commonly observed in many cancer cells. However, cellula...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/59714003" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1af435f0f81df6ef8cb68d2c3f1d6da5" rel="nofollow" data-download="{"attachment_id":73494617,"asset_id":59714003,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/73494617/download_file?st=MTczMjQwMjc5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="130286617" href="https://nus.academia.edu/ZhiyuanGong">Zhiyuan Gong</a><script data-card-contents-for-user="130286617" type="text/json">{"id":130286617,"first_name":"Zhiyuan","last_name":"Gong","domain_name":"nus","page_name":"ZhiyuanGong","display_name":"Zhiyuan Gong","profile_url":"https://nus.academia.edu/ZhiyuanGong?f_ri=6970","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_59714003 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="59714003"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 59714003, container: ".js-paper-rank-work_59714003", }); 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Details of the mechanism of arsenic toxicity are still lacking and profile studies at metabolic level are very limited. Using gas chromatography coupled with mass spectroscopy (GC/MS), we first generated metabolomic profiles from the livers of arsenic-treated zebrafish and identified 34 significantly altered metabolite peaks as potential markers, including four prominent ones: cholic acid, glycylglycine, glycine and hypotaurine. Combined results from GC/MS, histological examination and pathway analyses suggested a series of alterations, including apoptosis, glycogenolysis, changes in amino acid metabolism and fatty acid composition, accumulation of bile acids and fats, and disturbance in glycolysis related energy metabolism. The alterations in glycolysis partially resemble Warburg effect commonly observed in many cancer cells. 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Hauser Jens (ed.): L'Art Biotech. Nantes/Trézélan, 2003. The... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_38609668" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Book (in French) published in 2003 at the occasion of the first exhibition staging exclusively biomedia art works at the national art center Le Lieu Unique in Nantes/France. Hauser Jens (ed.): L'Art Biotech. Nantes/Trézélan, 2003. <br /> <br />The publication has not been available anymore since 2008; this PDF is made accessible with the agreement and the kind support of the Filigranes publishing house, until an augmented new edition will be be available. Great thanks to Filigranes and Patrick Le Bescont! <a href="https://www.filigranes.com" rel="nofollow">https://www.filigranes.com</a></div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/38609668" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="16365190beb77ded4a3974e9de5d9fe6" rel="nofollow" data-download="{"attachment_id":58685388,"asset_id":38609668,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/58685388/download_file?st=MTczMjQwMjc5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="12524523" href="https://ku-dk.academia.edu/JensHauser">Jens Hauser</a><script data-card-contents-for-user="12524523" type="text/json">{"id":12524523,"first_name":"Jens","last_name":"Hauser","domain_name":"ku-dk","page_name":"JensHauser","display_name":"Jens Hauser","profile_url":"https://ku-dk.academia.edu/JensHauser?f_ri=6970","photo":"https://0.academia-photos.com/12524523/21715284/21033816/s65_jens.hauser.jpg"}</script></span></span></li><li class="js-paper-rank-work_38609668 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="38609668"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 38609668, container: ".js-paper-rank-work_38609668", }); 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Hauser Jens (ed.): L'Art Biotech. Nantes/Trézélan, 2003. \r\n\r\nThe publication has not been available anymore since 2008; this PDF is made accessible with the agreement and the kind support of the Filigranes publishing house, until an augmented new edition will be be available. Great thanks to Filigranes and Patrick Le Bescont! https://www.filigranes.com\r\n","downloadable_attachments":[{"id":58685388,"asset_id":38609668,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":12524523,"first_name":"Jens","last_name":"Hauser","domain_name":"ku-dk","page_name":"JensHauser","display_name":"Jens Hauser","profile_url":"https://ku-dk.academia.edu/JensHauser?f_ri=6970","photo":"https://0.academia-photos.com/12524523/21715284/21033816/s65_jens.hauser.jpg"}],"research_interests":[{"id":155,"name":"Evolutionary Biology","url":"https://www.academia.edu/Documents/in/Evolutionary_Biology?f_ri=6970","nofollow":false},{"id":803,"name":"Philosophy","url":"https://www.academia.edu/Documents/in/Philosophy?f_ri=6970","nofollow":false},{"id":815,"name":"Epistemology","url":"https://www.academia.edu/Documents/in/Epistemology?f_ri=6970","nofollow":false},{"id":821,"name":"Philosophy of 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var workId = 2980632; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_2980632"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_2980632 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="2980632"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 2980632; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=2980632]").text(description); $(".js-view-count-work_2980632").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_2980632").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="2980632"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">6</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="392" href="https://www.academia.edu/Documents/in/Archaeology">Archaeology</a>, <script data-card-contents-for-ri="392" type="text/json">{"id":392,"name":"Archaeology","url":"https://www.academia.edu/Documents/in/Archaeology?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="67648" href="https://www.academia.edu/Documents/in/GC-MS">GC-MS</a>, <script data-card-contents-for-ri="67648" type="text/json">{"id":67648,"name":"GC-MS","url":"https://www.academia.edu/Documents/in/GC-MS?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="91257" href="https://www.academia.edu/Documents/in/Stable_Isotope">Stable Isotope</a><script data-card-contents-for-ri="91257" type="text/json">{"id":91257,"name":"Stable Isotope","url":"https://www.academia.edu/Documents/in/Stable_Isotope?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=2980632]'), work: {"id":2980632,"title":"Molecular and isotopic archaeology: Top grade tools to investigate organic archaeological materials","created_at":"2013-03-13T21:19:53.208-07:00","url":"https://www.academia.edu/2980632/Molecular_and_isotopic_archaeology_Top_grade_tools_to_investigate_organic_archaeological_materials?f_ri=6970","dom_id":"work_2980632","summary":null,"downloadable_attachments":[{"id":31544224,"asset_id":2980632,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":3477335,"first_name":"Armelle","last_name":"Charrié (-Duhaut)","domain_name":"unistra","page_name":"ArmelleCharriéDuhaut","display_name":"Armelle Charrié (-Duhaut)","profile_url":"https://unistra.academia.edu/ArmelleCharri%C3%A9Duhaut?f_ri=6970","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":392,"name":"Archaeology","url":"https://www.academia.edu/Documents/in/Archaeology?f_ri=6970","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":67648,"name":"GC-MS","url":"https://www.academia.edu/Documents/in/GC-MS?f_ri=6970","nofollow":false},{"id":91257,"name":"Stable Isotope","url":"https://www.academia.edu/Documents/in/Stable_Isotope?f_ri=6970","nofollow":false},{"id":107083,"name":"Method","url":"https://www.academia.edu/Documents/in/Method?f_ri=6970"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_79379629" data-work_id="79379629" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/79379629/Short_term_effects_of_dietary_advanced_glycation_end_products_in_rats">Short-term effects of dietary advanced glycation end products in rats</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Dietary advanced glycation end products (AGE) formed during heating of food have gained interest as potential nutritional toxins with adverse effects on inflammation and glucose metabolism. In the present study, we investigated the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_79379629" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Dietary advanced glycation end products (AGE) formed during heating of food have gained interest as potential nutritional toxins with adverse effects on inflammation and glucose metabolism. In the present study, we investigated the short-term effects of high and low molecular weight (HMW and LMW) dietary AGE on insulin sensitivity, expression of the receptor for AGE (RAGE), the AGE receptor 1 (AGER1) andTNF-α, F2-isoprostaglandins, body composition and food intake. For 2 weeks, thirty-six Sprague–Dawley rats were fed a diet containing 20 % milk powder with different proportions of this being given as heated milk powder (0, 40 or 100 %), either native (HMW) or hydrolysed (LMW). Gene expression ofRAGEandAGER1in whole blood increased in the group receiving a high AGE LMW diet, which also had the highest urinary excretion of the AGE, methylglyoxal-derived hydroimidazolone 1 (MG-H1). Urinary excretion ofNε-carboxymethyl-lysine increased with increasing proportion of heat-treated milk pow...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/79379629" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7304f03ea99f2e3adf03289b5e063808" rel="nofollow" data-download="{"attachment_id":86114868,"asset_id":79379629,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/86114868/download_file?st=MTczMjQwMjc5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39001226" href="https://nocuffs.academia.edu/AndreasMadsen">Andreas Madsen</a><script data-card-contents-for-user="39001226" type="text/json">{"id":39001226,"first_name":"Andreas","last_name":"Madsen","domain_name":"nocuffs","page_name":"AndreasMadsen","display_name":"Andreas Madsen","profile_url":"https://nocuffs.academia.edu/AndreasMadsen?f_ri=6970","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_79379629 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="79379629"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 79379629, container: ".js-paper-rank-work_79379629", }); 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$(".js-view-count[data-work-id=79379629]").text(description); $(".js-view-count-work_79379629").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_79379629").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="79379629"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">19</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="591" href="https://www.academia.edu/Documents/in/Nutrition_and_Dietetics">Nutrition and Dietetics</a>, <script data-card-contents-for-ri="591" type="text/json">{"id":591,"name":"Nutrition and Dietetics","url":"https://www.academia.edu/Documents/in/Nutrition_and_Dietetics?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9478" href="https://www.academia.edu/Documents/in/Diet">Diet</a>, <script data-card-contents-for-ri="9478" type="text/json">{"id":9478,"name":"Diet","url":"https://www.academia.edu/Documents/in/Diet?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="23890" href="https://www.academia.edu/Documents/in/Comparative_Study">Comparative Study</a><script data-card-contents-for-ri="23890" type="text/json">{"id":23890,"name":"Comparative Study","url":"https://www.academia.edu/Documents/in/Comparative_Study?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=79379629]'), work: {"id":79379629,"title":"Short-term effects of dietary advanced glycation end products in rats","created_at":"2022-05-18T06:19:50.955-07:00","url":"https://www.academia.edu/79379629/Short_term_effects_of_dietary_advanced_glycation_end_products_in_rats?f_ri=6970","dom_id":"work_79379629","summary":"Dietary advanced glycation end products (AGE) formed during heating of food have gained interest as potential nutritional toxins with adverse effects on inflammation and glucose metabolism. In the present study, we investigated the short-term effects of high and low molecular weight (HMW and LMW) dietary AGE on insulin sensitivity, expression of the receptor for AGE (RAGE), the AGE receptor 1 (AGER1) andTNF-α, F2-isoprostaglandins, body composition and food intake. For 2 weeks, thirty-six Sprague–Dawley rats were fed a diet containing 20 % milk powder with different proportions of this being given as heated milk powder (0, 40 or 100 %), either native (HMW) or hydrolysed (LMW). Gene expression ofRAGEandAGER1in whole blood increased in the group receiving a high AGE LMW diet, which also had the highest urinary excretion of the AGE, methylglyoxal-derived hydroimidazolone 1 (MG-H1). Urinary excretion ofNε-carboxymethyl-lysine increased with increasing proportion of heat-treated milk pow...","downloadable_attachments":[{"id":86114868,"asset_id":79379629,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39001226,"first_name":"Andreas","last_name":"Madsen","domain_name":"nocuffs","page_name":"AndreasMadsen","display_name":"Andreas Madsen","profile_url":"https://nocuffs.academia.edu/AndreasMadsen?f_ri=6970","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":591,"name":"Nutrition and Dietetics","url":"https://www.academia.edu/Documents/in/Nutrition_and_Dietetics?f_ri=6970","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":9478,"name":"Diet","url":"https://www.academia.edu/Documents/in/Diet?f_ri=6970","nofollow":false},{"id":23890,"name":"Comparative Study","url":"https://www.academia.edu/Documents/in/Comparative_Study?f_ri=6970","nofollow":false},{"id":29980,"name":"Animal Production","url":"https://www.academia.edu/Documents/in/Animal_Production?f_ri=6970"},{"id":60979,"name":"Glycation","url":"https://www.academia.edu/Documents/in/Glycation?f_ri=6970"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine?f_ri=6970"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=6970"},{"id":105510,"name":"Journal Article","url":"https://www.academia.edu/Documents/in/Journal_Article?f_ri=6970"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=6970"},{"id":373650,"name":"Lysine","url":"https://www.academia.edu/Documents/in/Lysine?f_ri=6970"},{"id":474029,"name":"Tumor necrosis factor-alpha","url":"https://www.academia.edu/Documents/in/Tumor_necrosis_factor-alpha?f_ri=6970"},{"id":573653,"name":"Food Sciences","url":"https://www.academia.edu/Documents/in/Food_Sciences?f_ri=6970"},{"id":695018,"name":"Molecular weight","url":"https://www.academia.edu/Documents/in/Molecular_weight?f_ri=6970"},{"id":801409,"name":"Imidazoles","url":"https://www.academia.edu/Documents/in/Imidazoles?f_ri=6970"},{"id":1567539,"name":"Energy Intake","url":"https://www.academia.edu/Documents/in/Energy_Intake?f_ri=6970"},{"id":1885346,"name":"Milk proteins","url":"https://www.academia.edu/Documents/in/Milk_proteins?f_ri=6970"},{"id":2463495,"name":"Random Allocation","url":"https://www.academia.edu/Documents/in/Random_Allocation?f_ri=6970"},{"id":3032547,"name":"proteolysis","url":"https://www.academia.edu/Documents/in/proteolysis?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_73257120" data-work_id="73257120" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/73257120/Analysis_of_blood_based_gene_expression_in_idiopathic_Parkinson_disease">Analysis of blood-based gene expression in idiopathic Parkinson disease</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objective:To examine whether gene expression analysis of a large-scale Parkinson disease (PD) patient cohort produces a robust blood-based PD gene signature compared to previous studies that have used relatively small cohorts (≤220... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_73257120" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objective:To examine whether gene expression analysis of a large-scale Parkinson disease (PD) patient cohort produces a robust blood-based PD gene signature compared to previous studies that have used relatively small cohorts (≤220 samples).Methods:Whole-blood gene expression profiles were collected from a total of 523 individuals. After preprocessing, the data contained 486 gene profiles (n = 205 PD, n = 233 controls, n = 48 other neurodegenerative diseases) that were partitioned into training, validation, and independent test cohorts to identify and validate a gene signature. Batch-effect reduction and cross-validation were performed to ensure signature reliability. Finally, functional and pathway enrichment analyses were applied to the signature to identify PD-associated gene networks.Results:A gene signature of 100 probes that mapped to 87 genes, corresponding to 64 upregulated and 23 downregulated genes differentiating between patients with idiopathic PD and controls, was ident...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73257120" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d300b10b1d78736bdd2a522ce9454313" rel="nofollow" data-download="{"attachment_id":81847780,"asset_id":73257120,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/81847780/download_file?st=MTczMjQwMjc5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="159390476" href="https://independent.academia.edu/ROnShamir">ROn Shamir</a><script data-card-contents-for-user="159390476" type="text/json">{"id":159390476,"first_name":"ROn","last_name":"Shamir","domain_name":"independent","page_name":"ROnShamir","display_name":"ROn Shamir","profile_url":"https://independent.academia.edu/ROnShamir?f_ri=6970","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_73257120 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="73257120"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 73257120, container: ".js-paper-rank-work_73257120", }); 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$(".js-view-count[data-work-id=73257120]").text(description); $(".js-view-count-work_73257120").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_73257120").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="73257120"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">19</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="237" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="623" href="https://www.academia.edu/Documents/in/Neurology">Neurology</a>, <script data-card-contents-for-ri="623" type="text/json">{"id":623,"name":"Neurology","url":"https://www.academia.edu/Documents/in/Neurology?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7710" href="https://www.academia.edu/Documents/in/Biology">Biology</a><script data-card-contents-for-ri="7710" type="text/json">{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=73257120]'), work: {"id":73257120,"title":"Analysis of blood-based gene expression in idiopathic Parkinson disease","created_at":"2022-03-07T09:02:02.516-08:00","url":"https://www.academia.edu/73257120/Analysis_of_blood_based_gene_expression_in_idiopathic_Parkinson_disease?f_ri=6970","dom_id":"work_73257120","summary":"Objective:To examine whether gene expression analysis of a large-scale Parkinson disease (PD) patient cohort produces a robust blood-based PD gene signature compared to previous studies that have used relatively small cohorts (≤220 samples).Methods:Whole-blood gene expression profiles were collected from a total of 523 individuals. After preprocessing, the data contained 486 gene profiles (n = 205 PD, n = 233 controls, n = 48 other neurodegenerative diseases) that were partitioned into training, validation, and independent test cohorts to identify and validate a gene signature. Batch-effect reduction and cross-validation were performed to ensure signature reliability. Finally, functional and pathway enrichment analyses were applied to the signature to identify PD-associated gene networks.Results:A gene signature of 100 probes that mapped to 87 genes, corresponding to 64 upregulated and 23 downregulated genes differentiating between patients with idiopathic PD and controls, was ident...","downloadable_attachments":[{"id":81847780,"asset_id":73257120,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":159390476,"first_name":"ROn","last_name":"Shamir","domain_name":"independent","page_name":"ROnShamir","display_name":"ROn Shamir","profile_url":"https://independent.academia.edu/ROnShamir?f_ri=6970","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=6970","nofollow":false},{"id":623,"name":"Neurology","url":"https://www.academia.edu/Documents/in/Neurology?f_ri=6970","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=6970","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=6970"},{"id":37848,"name":"Neurodegenerative Diseases","url":"https://www.academia.edu/Documents/in/Neurodegenerative_Diseases?f_ri=6970"},{"id":43761,"name":"Transcriptome","url":"https://www.academia.edu/Documents/in/Transcriptome?f_ri=6970"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=6970"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=6970"},{"id":194916,"name":"ROC Curve","url":"https://www.academia.edu/Documents/in/ROC_Curve?f_ri=6970"},{"id":210852,"name":"Gene Regulatory Networks","url":"https://www.academia.edu/Documents/in/Gene_Regulatory_Networks?f_ri=6970"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=6970"},{"id":375301,"name":"Microarray Analysis","url":"https://www.academia.edu/Documents/in/Microarray_Analysis?f_ri=6970"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=6970"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=6970"},{"id":1541077,"name":"Parkinson Disease","url":"https://www.academia.edu/Documents/in/Parkinson_Disease?f_ri=6970"},{"id":1810445,"name":"Gene expression profiling","url":"https://www.academia.edu/Documents/in/Gene_expression_profiling?f_ri=6970"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_51558838" data-work_id="51558838" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/51558838/Predictive_role_of_circulating_endothelial_derived_microparticles_in_cardiovascular_diseases">Predictive role of circulating endothelial-derived microparticles in cardiovascular diseases</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Endothelial-derived microparticles (EMPs) are a novel biological marker of endothelium injury and vasomotion disorders that are involved in pathogenesis of cardiovascular, metabolic, and inflammatory diseases. Circulating levels of EMPs... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_51558838" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Endothelial-derived microparticles (EMPs) are a novel biological marker of endothelium injury and vasomotion disorders that are involved in pathogenesis of cardiovascular, metabolic, and inflammatory diseases. Circulating levels of EMPs are thought to reflect a balance between cell stimulation, proliferation, apoptosis, and cell death. Increased EMPs may be defined in several cardiovascular diseases, such as stable and unstable coronary artery disease, acute and chronic heart failure, hypertension, arrhythmias, thromboembolism, asymptomatic atherosclerosis as well as renal failure, metabolic disorders (including type two diabetes mellitus, abdominal obesity, metabolic syndrome, insulin resistance) and dyslipidemia. This review highlights the controversial opinions regarding impact of circulating EMPs in major cardiovascular and metabolic diseases and summarizes the perspective implementation of the EMPs in risk stratification models.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/51558838" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="72438709" href="https://independent.academia.edu/AlexanderBerezin1">Alexander E Berezin</a><script data-card-contents-for-user="72438709" type="text/json">{"id":72438709,"first_name":"Alexander","last_name":"Berezin","domain_name":"independent","page_name":"AlexanderBerezin1","display_name":"Alexander E Berezin","profile_url":"https://independent.academia.edu/AlexanderBerezin1?f_ri=6970","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_51558838 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="51558838"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 51558838, container: ".js-paper-rank-work_51558838", }); 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Circulating levels of EMPs are thought to reflect a balance between cell stimulation, proliferation, apoptosis, and cell death. Increased EMPs may be defined in several cardiovascular diseases, such as stable and unstable coronary artery disease, acute and chronic heart failure, hypertension, arrhythmias, thromboembolism, asymptomatic atherosclerosis as well as renal failure, metabolic disorders (including type two diabetes mellitus, abdominal obesity, metabolic syndrome, insulin resistance) and dyslipidemia. This review highlights the controversial opinions regarding impact of circulating EMPs in major cardiovascular and metabolic diseases and summarizes the perspective implementation of the EMPs in risk stratification models.","downloadable_attachments":[],"ordered_authors":[{"id":72438709,"first_name":"Alexander","last_name":"Berezin","domain_name":"independent","page_name":"AlexanderBerezin1","display_name":"Alexander E Berezin","profile_url":"https://independent.academia.edu/AlexanderBerezin1?f_ri=6970","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":14034,"name":"Clinical Biochemistry","url":"https://www.academia.edu/Documents/in/Clinical_Biochemistry?f_ri=6970","nofollow":false},{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=6970","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970","nofollow":false},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus?f_ri=6970"},{"id":138877,"name":"Vascular endothelium","url":"https://www.academia.edu/Documents/in/Vascular_endothelium?f_ri=6970"},{"id":559242,"name":"Cardiovascular Diseases","url":"https://www.academia.edu/Documents/in/Cardiovascular_Diseases?f_ri=6970"},{"id":622589,"name":"Risk Assessment","url":"https://www.academia.edu/Documents/in/Risk_Assessment-2?f_ri=6970"},{"id":1106287,"name":"Chronic Kidney Failure","url":"https://www.academia.edu/Documents/in/Chronic_Kidney_Failure?f_ri=6970"},{"id":2922718,"name":"Metabolic Syndrome X","url":"https://www.academia.edu/Documents/in/Metabolic_Syndrome_X?f_ri=6970"},{"id":3789880,"name":"Medical biochemistry and metabolomics","url":"https://www.academia.edu/Documents/in/Medical_biochemistry_and_metabolomics?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_47253673" data-work_id="47253673" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/47253673/Oleuropein_Offers_Cardioprotection_in_Rats_with_Acute_Myocardial_Infarction">Oleuropein Offers Cardioprotection in Rats with Acute Myocardial Infarction</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/47253673" data-share-source="work_strip" 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itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="177877126" href="https://independent.academia.edu/AliAkbarNekooeian">Ali Akbar Nekooeian</a><script data-card-contents-for-user="177877126" type="text/json">{"id":177877126,"first_name":"Ali Akbar","last_name":"Nekooeian","domain_name":"independent","page_name":"AliAkbarNekooeian","display_name":"Ali Akbar Nekooeian","profile_url":"https://independent.academia.edu/AliAkbarNekooeian?f_ri=6970","photo":"https://0.academia-photos.com/177877126/161678592/151409619/s65_ali_akbar.nekooeian.png"}</script></span></span></li><li class="js-paper-rank-work_47253673 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="47253673"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 47253673, container: 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class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/9518864/Selective_binding_and_enrichment_for_low_molecular_weight_biomarker_molecules_in_human_plasma_after_exposure_to_nanoporous_silica_particles">Selective binding and enrichment for low-molecular weight biomarker molecules in human plasma after exposure to nanoporous silica particles</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The present manuscript describes a biomarker capturing strategy based on nanoporous silica particles. The method is shown to enrich the yield of species in the low-molecular weight proteome (LMWP), allowing detection of small peptides in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_9518864" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The present manuscript describes a biomarker capturing strategy based on nanoporous silica particles. The method is shown to enrich the yield of species in the low-molecular weight proteome (LMWP), allowing detection of small peptides in the low-nanomolar range. Plasma samples were exposed to the silica particles, and the captured molecular species were profiled using MALDI-TOF. Mass spectra of the silica-treated human plasma samples showed a significant enrichment in MALDI-TOF protein profiles in the LMWP. Preliminary results indicated good level of reproducibility in plasma profiles with CVs on peak heights ranging from 6.3 to 14.7%. The MALDI-TOF signature changed significantly when the characteristics of the nanoporous silica were altered. The facile sample pretreatment before MS analysis, coupled to the potential for tailoring the surface properties of silica supports, hold promise for improving the recovery of low-abundance serum biomarkers.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/9518864" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="35973508415e555d91355d129d3b3286" rel="nofollow" data-download="{"attachment_id":47746088,"asset_id":9518864,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47746088/download_file?st=MTczMjQwMjc5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="22341917" href="https://independent.academia.edu/FlavianoTesta">Flaviano Testa</a><script data-card-contents-for-user="22341917" type="text/json">{"id":22341917,"first_name":"Flaviano","last_name":"Testa","domain_name":"independent","page_name":"FlavianoTesta","display_name":"Flaviano Testa","profile_url":"https://independent.academia.edu/FlavianoTesta?f_ri=6970","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_9518864 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="9518864"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 9518864, container: ".js-paper-rank-work_9518864", }); 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The method is shown to enrich the yield of species in the low-molecular weight proteome (LMWP), allowing detection of small peptides in the low-nanomolar range. Plasma samples were exposed to the silica particles, and the captured molecular species were profiled using MALDI-TOF. Mass spectra of the silica-treated human plasma samples showed a significant enrichment in MALDI-TOF protein profiles in the LMWP. Preliminary results indicated good level of reproducibility in plasma profiles with CVs on peak heights ranging from 6.3 to 14.7%. The MALDI-TOF signature changed significantly when the characteristics of the nanoporous silica were altered. The facile sample pretreatment before MS analysis, coupled to the potential for tailoring the surface properties of silica supports, hold promise for improving the recovery of low-abundance serum biomarkers.","downloadable_attachments":[{"id":47746088,"asset_id":9518864,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":22341917,"first_name":"Flaviano","last_name":"Testa","domain_name":"independent","page_name":"FlavianoTesta","display_name":"Flaviano Testa","profile_url":"https://independent.academia.edu/FlavianoTesta?f_ri=6970","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry?f_ri=6970","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":9786,"name":"Proteomics","url":"https://www.academia.edu/Documents/in/Proteomics?f_ri=6970","nofollow":false},{"id":17733,"name":"Nanotechnology","url":"https://www.academia.edu/Documents/in/Nanotechnology?f_ri=6970","nofollow":false},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=6970"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970"},{"id":98440,"name":"Silica","url":"https://www.academia.edu/Documents/in/Silica?f_ri=6970"},{"id":111748,"name":"Nanotubes","url":"https://www.academia.edu/Documents/in/Nanotubes?f_ri=6970"},{"id":568482,"name":"Biological 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B-Cell Lymphoma in the Era of the NCCN-IPI</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/77238705" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="24e4fe06942b1718d37454802cae8777" rel="nofollow" data-download="{"attachment_id":84692228,"asset_id":77238705,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_77238705 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="77238705"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 77238705; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=77238705]").text(description); $(".js-view-count-work_77238705").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_77238705").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div 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href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a><script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=77238705]'), work: {"id":77238705,"title":"Independent Prognostic Value of Serum Markers in Diffuse Large B-Cell Lymphoma in the Era of the 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Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged?f_ri=6970"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult?f_ri=6970"},{"id":439237,"name":"Rituximab","url":"https://www.academia.edu/Documents/in/Rituximab?f_ri=6970"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=6970"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=6970"},{"id":541328,"name":"Diffuse Large B-Cell Lymphoma","url":"https://www.academia.edu/Documents/in/Diffuse_Large_B-Cell_Lymphoma?f_ri=6970"},{"id":889702,"name":"Anthracyclines","url":"https://www.academia.edu/Documents/in/Anthracyclines?f_ri=6970"},{"id":3118074,"name":"Neoplasm staging","url":"https://www.academia.edu/Documents/in/Neoplasm_staging?f_ri=6970"},{"id":4073093,"name":"Inflammation Mediators","url":"https://www.academia.edu/Documents/in/Inflammation_Mediators?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_75928780" data-work_id="75928780" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/75928780/European_contribution_to_the_study_of_ROS_A_summary_of_the_findings_and_prospects_for_the_future_from_the_COST_action_BM1203_EU_ROS_">European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_75928780" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associat...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/75928780" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4841cc4d273669b3a87ca16357145f0c" rel="nofollow" data-download="{"attachment_id":83597828,"asset_id":75928780,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/83597828/download_file?st=MTczMjQwMjc5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="36754755" href="https://exeter.academia.edu/PaulWinyard">Paul G Winyard</a><script data-card-contents-for-user="36754755" type="text/json">{"id":36754755,"first_name":"Paul","last_name":"Winyard","domain_name":"exeter","page_name":"PaulWinyard","display_name":"Paul G Winyard","profile_url":"https://exeter.academia.edu/PaulWinyard?f_ri=6970","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_75928780 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="75928780"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 75928780, container: ".js-paper-rank-work_75928780", }); });</script></li><li class="js-percentile-work_75928780 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75928780; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_75928780"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_75928780 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="75928780"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75928780; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75928780]").text(description); $(".js-view-count-work_75928780").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_75928780").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="75928780"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2513" href="https://www.academia.edu/Documents/in/Molecular_Biology">Molecular Biology</a>, <script data-card-contents-for-ri="2513" type="text/json">{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7710" href="https://www.academia.edu/Documents/in/Biology">Biology</a>, <script data-card-contents-for-ri="7710" type="text/json">{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10347" href="https://www.academia.edu/Documents/in/European_Union">European Union</a><script data-card-contents-for-ri="10347" type="text/json">{"id":10347,"name":"European Union","url":"https://www.academia.edu/Documents/in/European_Union?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=75928780]'), work: {"id":75928780,"title":"European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)","created_at":"2022-04-09T10:55:35.939-07:00","url":"https://www.academia.edu/75928780/European_contribution_to_the_study_of_ROS_A_summary_of_the_findings_and_prospects_for_the_future_from_the_COST_action_BM1203_EU_ROS_?f_ri=6970","dom_id":"work_75928780","summary":"The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associat...","downloadable_attachments":[{"id":83597828,"asset_id":75928780,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":36754755,"first_name":"Paul","last_name":"Winyard","domain_name":"exeter","page_name":"PaulWinyard","display_name":"Paul G Winyard","profile_url":"https://exeter.academia.edu/PaulWinyard?f_ri=6970","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology?f_ri=6970","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=6970","nofollow":false},{"id":10347,"name":"European Union","url":"https://www.academia.edu/Documents/in/European_Union?f_ri=6970","nofollow":false},{"id":12054,"name":"International Cooperation","url":"https://www.academia.edu/Documents/in/International_Cooperation?f_ri=6970"},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress?f_ri=6970"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=6970"},{"id":32696,"name":"Scientific Societies","url":"https://www.academia.edu/Documents/in/Scientific_Societies?f_ri=6970"},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=6970"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970"},{"id":82978,"name":"Reactive Oxygen Species","url":"https://www.academia.edu/Documents/in/Reactive_Oxygen_Species?f_ri=6970"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=6970"},{"id":897823,"name":"Elsevier","url":"https://www.academia.edu/Documents/in/Elsevier?f_ri=6970"},{"id":1009236,"name":"Redox","url":"https://www.academia.edu/Documents/in/Redox?f_ri=6970"},{"id":1256747,"name":"Oxidation-Reduction","url":"https://www.academia.edu/Documents/in/Oxidation-Reduction?f_ri=6970"},{"id":4104326,"name":"Redox biology","url":"https://www.academia.edu/Documents/in/Redox_biology?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_61465373" data-work_id="61465373" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/61465373/Salivary_Biomarkers_and_Training_Load_During_Training_and_Competition_in_Paralympic_Swimmers">Salivary Biomarkers and Training Load During Training and Competition in Paralympic Swimmers</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Stress responses in athletes can be attributed to training and competition, where increased physiological and psychological stress may negatively affect performance and recovery. To examine the relationship between training load (TL) and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_61465373" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Stress responses in athletes can be attributed to training and competition, where increased physiological and psychological stress may negatively affect performance and recovery. To examine the relationship between training load (TL) and salivary biomarkers immunoglobulin A (IgA), alpha-amylase (AA), and cortisol across a 16-wk preparation phase and 10-d competition phase in Paralympic swimmers. Four Paralympic swimmers provided biweekly saliva samples during 3 training phases-(1) normal training, (2) intensified training, and (3) taper-as well as daily saliva samples in the 10-d Paralympic competition (2016 Paralympic Games). TL was measured using session rating of perceived exertion. Multilevel analysis identified a significant increase in salivary immunoglobulin A (sIgA: 94.98 [27.69] μg·mL), salivary alpha-amylase (sAA: 45.78 [19.07] μg·mL), and salivary cortisol (7.92 [2.17] nM) during intensified training concurrent with a 38.3% increase in TL. During the taper phase, a 49.5% ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/61465373" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c75d8166827ed1bf25115aeb8cb27b87" rel="nofollow" data-download="{"attachment_id":74487865,"asset_id":61465373,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/74487865/download_file?st=MTczMjQwMjc5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="69986673" href="https://limerick.academia.edu/CiaraOConnor">Ciara O'Connor</a><script data-card-contents-for-user="69986673" type="text/json">{"id":69986673,"first_name":"Ciara","last_name":"O'Connor","domain_name":"limerick","page_name":"CiaraOConnor","display_name":"Ciara O'Connor","profile_url":"https://limerick.academia.edu/CiaraOConnor?f_ri=6970","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_61465373 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="61465373"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 61465373, container: ".js-paper-rank-work_61465373", }); 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To examine the relationship between training load (TL) and salivary biomarkers immunoglobulin A (IgA), alpha-amylase (AA), and cortisol across a 16-wk preparation phase and 10-d competition phase in Paralympic swimmers. Four Paralympic swimmers provided biweekly saliva samples during 3 training phases-(1) normal training, (2) intensified training, and (3) taper-as well as daily saliva samples in the 10-d Paralympic competition (2016 Paralympic Games). TL was measured using session rating of perceived exertion. Multilevel analysis identified a significant increase in salivary immunoglobulin A (sIgA: 94.98 [27.69] μg·mL), salivary alpha-amylase (sAA: 45.78 [19.07] μg·mL), and salivary cortisol (7.92 [2.17] nM) during intensified training concurrent with a 38.3% increase in TL. During the taper phase, a 49.5% ...","downloadable_attachments":[{"id":74487865,"asset_id":61465373,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":69986673,"first_name":"Ciara","last_name":"O'Connor","domain_name":"limerick","page_name":"CiaraOConnor","display_name":"Ciara 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u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13208932" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a464c735aa3f037e29c7d9641fd3aaa1" rel="nofollow" data-download="{"attachment_id":45589784,"asset_id":13208932,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/45589784/download_file?st=MTczMjQwMjc5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase 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href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a>, <script data-card-contents-for-ri="400" type="text/json">{"id":400,"name":"Earth Sciences","url":"https://www.academia.edu/Documents/in/Earth_Sciences?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4580" href="https://www.academia.edu/Documents/in/Organic_Geochemistry">Organic Geochemistry</a>, <script data-card-contents-for-ri="4580" type="text/json">{"id":4580,"name":"Organic Geochemistry","url":"https://www.academia.edu/Documents/in/Organic_Geochemistry?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="5303" href="https://www.academia.edu/Documents/in/Carbon">Carbon</a>, <script data-card-contents-for-ri="5303" type="text/json">{"id":5303,"name":"Carbon","url":"https://www.academia.edu/Documents/in/Carbon?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6970" 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Sediment","url":"https://www.academia.edu/Documents/in/Marine_Sediment?f_ri=6970"},{"id":338534,"name":"Biomarker","url":"https://www.academia.edu/Documents/in/Biomarker?f_ri=6970"},{"id":365220,"name":"Bioindicator","url":"https://www.academia.edu/Documents/in/Bioindicator?f_ri=6970"},{"id":504382,"name":"Source Rocks","url":"https://www.academia.edu/Documents/in/Source_Rocks?f_ri=6970"},{"id":531422,"name":"North Sea","url":"https://www.academia.edu/Documents/in/North_Sea?f_ri=6970"},{"id":965524,"name":"Ternary Plot","url":"https://www.academia.edu/Documents/in/Ternary_Plot?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13876583" data-work_id="13876583" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13876583/Evaluation_of_D_Dimer_CXCL8_Homocysteine_Eosinophil_Cationic_Peptide_25_OH_Vitamin_D_and_immune_modulator_OX_2_Levels_in_Allergic_Patients">Evaluation of D-Dimer, CXCL8, Homocysteine, Eosinophil Cationic Peptide, 25(OH)-Vitamin D and immune modulator OX-2 Levels in Allergic Patients</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Information on sCD200 (OX-2), 25-Hydroxyvitamin-D(25(OH)D), homocysteine (hcy), eosinophil cationic peptid (ECP), d-dimer (DD), CXCL8, fractional exhale nitric oxide concentrations (FeNO) status all together among patients with allergy in... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_13876583" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Information on sCD200 (OX-2), 25-Hydroxyvitamin-D(25(OH)D), homocysteine (hcy), eosinophil cationic peptid (ECP), d-dimer (DD), CXCL8, fractional exhale nitric oxide concentrations (FeNO) status all together among patients with allergy in mediterranean region in comparison of climatic conditions have not been well established yet. Blood samples were taken on May and June during the highest air pollination. Hence, this study was undertaken to compare these serum biomolecules’ levels in allergic patients and matched controls, to evaluate disease characteristics. The study participants (n=129) included 25 healthy individuals (controls) and 104 allergic patients. Consecutive patients with allergic disease (Group II,III,IV,V) above the age of 18 years, managed. In the control group there was a significant positive correlation between ECP and BMI. Positive correlations between ECP, IgE and OX-2 were detected in group IV. For group V patients, positive correlations between age and IgE and ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13876583" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6ff745fa249515f411020ffe8946067c" rel="nofollow" data-download="{"attachment_id":39136789,"asset_id":13876583,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/39136789/download_file?st=MTczMjQwMjc5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="32955270" href="https://independent.academia.edu/OnurSeda">Seda Onur</a><script data-card-contents-for-user="32955270" type="text/json">{"id":32955270,"first_name":"Seda","last_name":"Onur","domain_name":"independent","page_name":"OnurSeda","display_name":"Seda Onur","profile_url":"https://independent.academia.edu/OnurSeda?f_ri=6970","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_13876583 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="13876583"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 13876583, container: ".js-paper-rank-work_13876583", }); 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$(".js-view-count[data-work-id=13876583]").text(description); $(".js-view-count-work_13876583").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_13876583").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="13876583"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9531" href="https://www.academia.edu/Documents/in/Vitamin_D">Vitamin D</a>, <script data-card-contents-for-ri="9531" type="text/json">{"id":9531,"name":"Vitamin D","url":"https://www.academia.edu/Documents/in/Vitamin_D?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9968" href="https://www.academia.edu/Documents/in/Asthma">Asthma</a>, <script data-card-contents-for-ri="9968" type="text/json">{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10966" href="https://www.academia.edu/Documents/in/Turkey">Turkey</a><script data-card-contents-for-ri="10966" type="text/json">{"id":10966,"name":"Turkey","url":"https://www.academia.edu/Documents/in/Turkey?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=13876583]'), work: {"id":13876583,"title":"Evaluation of D-Dimer, CXCL8, Homocysteine, Eosinophil Cationic Peptide, 25(OH)-Vitamin D and immune modulator OX-2 Levels in Allergic Patients","created_at":"2015-07-10T03:29:53.876-07:00","url":"https://www.academia.edu/13876583/Evaluation_of_D_Dimer_CXCL8_Homocysteine_Eosinophil_Cationic_Peptide_25_OH_Vitamin_D_and_immune_modulator_OX_2_Levels_in_Allergic_Patients?f_ri=6970","dom_id":"work_13876583","summary":"Information on sCD200 (OX-2), 25-Hydroxyvitamin-D(25(OH)D), homocysteine (hcy), eosinophil cationic peptid (ECP), d-dimer (DD), CXCL8, fractional exhale nitric oxide concentrations (FeNO) status all together among patients with allergy in mediterranean region in comparison of climatic conditions have not been well established yet. Blood samples were taken on May and June during the highest air pollination. Hence, this study was undertaken to compare these serum biomolecules’ levels in allergic patients and matched controls, to evaluate disease characteristics. The study participants (n=129) included 25 healthy individuals (controls) and 104 allergic patients. Consecutive patients with allergic disease (Group II,III,IV,V) above the age of 18 years, managed. In the control group there was a significant positive correlation between ECP and BMI. Positive correlations between ECP, IgE and OX-2 were detected in group IV. For group V patients, positive correlations between age and IgE and ...","downloadable_attachments":[{"id":39136789,"asset_id":13876583,"asset_type":"Work","always_allow_download":false},{"id":39136793,"asset_id":13876583,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":32955270,"first_name":"Seda","last_name":"Onur","domain_name":"independent","page_name":"OnurSeda","display_name":"Seda Onur","profile_url":"https://independent.academia.edu/OnurSeda?f_ri=6970","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":9531,"name":"Vitamin D","url":"https://www.academia.edu/Documents/in/Vitamin_D?f_ri=6970","nofollow":false},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=6970","nofollow":false},{"id":10966,"name":"Turkey","url":"https://www.academia.edu/Documents/in/Turkey?f_ri=6970","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970"},{"id":93922,"name":"Nitric oxide","url":"https://www.academia.edu/Documents/in/Nitric_oxide?f_ri=6970"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=6970"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=6970"},{"id":192564,"name":"Body Mass Index","url":"https://www.academia.edu/Documents/in/Body_Mass_Index?f_ri=6970"},{"id":195983,"name":"Homocysteine","url":"https://www.academia.edu/Documents/in/Homocysteine?f_ri=6970"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=6970"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged?f_ri=6970"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult?f_ri=6970"},{"id":413192,"name":"Sex Factors","url":"https://www.academia.edu/Documents/in/Sex_Factors?f_ri=6970"},{"id":546419,"name":"Age Factors","url":"https://www.academia.edu/Documents/in/Age_Factors?f_ri=6970"},{"id":1015202,"name":"Hypersensitivity","url":"https://www.academia.edu/Documents/in/Hypersensitivity?f_ri=6970"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21101361" data-work_id="21101361" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21101361/328_Genome_wide_analysis_of_CpG_island_methylation_in_bladder_cancer_identifies_novel_biomarkers_for_diagnosis_and_prediction_of_progression">328 Genome-wide analysis of CpG island methylation in bladder cancer identifies novel biomarkers for diagnosis and prediction of progression</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21101361" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="873d67c2d6473b77669b2d2e225dc992" rel="nofollow" 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type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="16664" href="https://www.academia.edu/Documents/in/Risk_assessment">Risk assessment</a>, <script data-card-contents-for-ri="16664" type="text/json">{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22404" href="https://www.academia.edu/Documents/in/Epigenetics">Epigenetics</a><script data-card-contents-for-ri="22404" type="text/json">{"id":22404,"name":"Epigenetics","url":"https://www.academia.edu/Documents/in/Epigenetics?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21101361]'), work: {"id":21101361,"title":"328 Genome-wide analysis of CpG island methylation in bladder cancer identifies novel biomarkers for diagnosis and prediction of progression","created_at":"2016-01-29T00:27:04.518-08:00","url":"https://www.academia.edu/21101361/328_Genome_wide_analysis_of_CpG_island_methylation_in_bladder_cancer_identifies_novel_biomarkers_for_diagnosis_and_prediction_of_progression?f_ri=6970","dom_id":"work_21101361","summary":null,"downloadable_attachments":[{"id":41714961,"asset_id":21101361,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":5570228,"first_name":"Angela","last_name":"van Tilborg","domain_name":"independent","page_name":"AngelavanTilborg","display_name":"Angela van Tilborg","profile_url":"https://independent.academia.edu/AngelavanTilborg?f_ri=6970","photo":"https://0.academia-photos.com/5570228/2920878/3415870/s65_angela.van_tilborg.jpg"}],"research_interests":[{"id":653,"name":"Urology","url":"https://www.academia.edu/Documents/in/Urology?f_ri=6970","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=6970","nofollow":false},{"id":22404,"name":"Epigenetics","url":"https://www.academia.edu/Documents/in/Epigenetics?f_ri=6970","nofollow":false},{"id":23323,"name":"Transcription Factors","url":"https://www.academia.edu/Documents/in/Transcription_Factors?f_ri=6970"},{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis?f_ri=6970"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=6970"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=6970"},{"id":121665,"name":"DNA methylation","url":"https://www.academia.edu/Documents/in/DNA_methylation?f_ri=6970"},{"id":121667,"name":"CpG islands","url":"https://www.academia.edu/Documents/in/CpG_islands?f_ri=6970"},{"id":157892,"name":"Netherlands","url":"https://www.academia.edu/Documents/in/Netherlands?f_ri=6970"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=6970"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype?f_ri=6970"},{"id":244814,"name":"Clinical 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Assessment","url":"https://www.academia.edu/Documents/in/Risk_Assessment-2?f_ri=6970"},{"id":901876,"name":"Sensitivity and Specificity","url":"https://www.academia.edu/Documents/in/Sensitivity_and_Specificity?f_ri=6970"},{"id":1272981,"name":"Proportional Hazards Models","url":"https://www.academia.edu/Documents/in/Proportional_Hazards_Models?f_ri=6970"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=6970"},{"id":1810445,"name":"Gene expression profiling","url":"https://www.academia.edu/Documents/in/Gene_expression_profiling?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_73760710" data-work_id="73760710" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/73760710/Demonstrating_test_retest_reliability_of_electrophysiological_measures_for_healthy_adults_in_a_multisite_study_of_biomarkers_of_antidepressant_treatment_response">Demonstrating test-retest reliability of electrophysiological measures for healthy adults in a multisite study of biomarkers of antidepressant treatment response</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Growing evidence suggests that loudness dependency of auditory evoked potentials (LDAEP) and resting EEG alpha and theta may be biological markers for predicting response to antidepressants. In spite of this promise, little is known about... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_73760710" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Growing evidence suggests that loudness dependency of auditory evoked potentials (LDAEP) and resting EEG alpha and theta may be biological markers for predicting response to antidepressants. In spite of this promise, little is known about the joint reliability of these markers, and thus their clinical applicability. New standardized procedures were developed to improve the compatibility of data acquired with different EEG platforms, and used to examine test-retest reliability for the three electrophysiological measures selected for a multisite project-Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC). Thirty-nine healthy controls across four clinical research sites were tested in two sessions separated by about 1 week. Resting EEG (eyes-open and eyes-closed conditions) was recorded and LDAEP measured using binaural tones (1000 Hz, 40 ms) at five intensities (60-100 dB SPL). Principal components analysis of current source density waveform...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73760710" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c0e16e2e9772516776fb3878cc569f08" rel="nofollow" data-download="{"attachment_id":82155717,"asset_id":73760710,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/82155717/download_file?st=MTczMjQwMjc5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="5433043" href="https://hms-harvard.academia.edu/ChristianWebb">Christian Webb</a><script data-card-contents-for-user="5433043" type="text/json">{"id":5433043,"first_name":"Christian","last_name":"Webb","domain_name":"hms-harvard","page_name":"ChristianWebb","display_name":"Christian Webb","profile_url":"https://hms-harvard.academia.edu/ChristianWebb?f_ri=6970","photo":"https://0.academia-photos.com/5433043/2386753/13593375/s65_christian.webb.jpg"}</script></span></span></li><li class="js-paper-rank-work_73760710 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="73760710"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 73760710, container: ".js-paper-rank-work_73760710", }); 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$(".js-view-count[data-work-id=73760710]").text(description); $(".js-view-count-work_73760710").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_73760710").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="73760710"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="221" href="https://www.academia.edu/Documents/in/Psychology">Psychology</a>, <script data-card-contents-for-ri="221" type="text/json">{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1026" href="https://www.academia.edu/Documents/in/Psychophysiology">Psychophysiology</a>, <script data-card-contents-for-ri="1026" type="text/json">{"id":1026,"name":"Psychophysiology","url":"https://www.academia.edu/Documents/in/Psychophysiology?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="5069" href="https://www.academia.edu/Documents/in/Principal_Component_Analysis">Principal Component Analysis</a>, <script data-card-contents-for-ri="5069" type="text/json">{"id":5069,"name":"Principal Component Analysis","url":"https://www.academia.edu/Documents/in/Principal_Component_Analysis?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a><script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=73760710]'), work: {"id":73760710,"title":"Demonstrating test-retest reliability of electrophysiological measures for healthy adults in a multisite study of biomarkers of antidepressant treatment response","created_at":"2022-03-14T11:00:28.081-07:00","url":"https://www.academia.edu/73760710/Demonstrating_test_retest_reliability_of_electrophysiological_measures_for_healthy_adults_in_a_multisite_study_of_biomarkers_of_antidepressant_treatment_response?f_ri=6970","dom_id":"work_73760710","summary":"Growing evidence suggests that loudness dependency of auditory evoked potentials (LDAEP) and resting EEG alpha and theta may be biological markers for predicting response to antidepressants. In spite of this promise, little is known about the joint reliability of these markers, and thus their clinical applicability. New standardized procedures were developed to improve the compatibility of data acquired with different EEG platforms, and used to examine test-retest reliability for the three electrophysiological measures selected for a multisite project-Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC). Thirty-nine healthy controls across four clinical research sites were tested in two sessions separated by about 1 week. Resting EEG (eyes-open and eyes-closed conditions) was recorded and LDAEP measured using binaural tones (1000 Hz, 40 ms) at five intensities (60-100 dB SPL). Principal components analysis of current source density waveform...","downloadable_attachments":[{"id":82155717,"asset_id":73760710,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":5433043,"first_name":"Christian","last_name":"Webb","domain_name":"hms-harvard","page_name":"ChristianWebb","display_name":"Christian Webb","profile_url":"https://hms-harvard.academia.edu/ChristianWebb?f_ri=6970","photo":"https://0.academia-photos.com/5433043/2386753/13593375/s65_christian.webb.jpg"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=6970","nofollow":false},{"id":1026,"name":"Psychophysiology","url":"https://www.academia.edu/Documents/in/Psychophysiology?f_ri=6970","nofollow":false},{"id":5069,"name":"Principal Component Analysis","url":"https://www.academia.edu/Documents/in/Principal_Component_Analysis?f_ri=6970","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":10904,"name":"Electroencephalography","url":"https://www.academia.edu/Documents/in/Electroencephalography?f_ri=6970"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=6970"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=6970"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970"},{"id":78467,"name":"Cerebral Cortex","url":"https://www.academia.edu/Documents/in/Cerebral_Cortex?f_ri=6970"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=6970"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=6970"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult?f_ri=6970"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=6970"},{"id":723371,"name":"Auditory Cortex","url":"https://www.academia.edu/Documents/in/Auditory_Cortex?f_ri=6970"},{"id":1275961,"name":"Alpha Rhythm","url":"https://www.academia.edu/Documents/in/Alpha_Rhythm?f_ri=6970"},{"id":1394091,"name":"Theta Rhythm","url":"https://www.academia.edu/Documents/in/Theta_Rhythm?f_ri=6970"},{"id":2428413,"name":"Acoustic Stimulation","url":"https://www.academia.edu/Documents/in/Acoustic_Stimulation?f_ri=6970"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences?f_ri=6970"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=6970"},{"id":3988408,"name":"Antidepressive agents","url":"https://www.academia.edu/Documents/in/Antidepressive_agents?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_66861460" data-work_id="66861460" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/66861460/Effect_of_N_acetyl_cysteine_and_vitamin_C_on_kidney_allograft_function_biomarkers_interleukin_18_and_neutrophil_gelatinase_associated_lipocalin">Effect of N-acetyl cysteine and vitamin C on kidney allograft function biomarkers interleukin-18 and neutrophil gelatinase-associated lipocalin</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">INTRODUCTION Delayed graft function (DGF) is a consequence of ischemia-reperfusion injuries in kidney allografts, for which no definite treatment is available. The neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_66861460" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">INTRODUCTION Delayed graft function (DGF) is a consequence of ischemia-reperfusion injuries in kidney allografts, for which no definite treatment is available. The neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) are introduced as the most promising urine biomarkers to detect DGF. N-acetylcysteine (NAC) and vitamin C, well-known potent antioxidants that scavenge free radicals, may alleviate kidney injury. This study investigated the protective effects of NAC alone and in combination with vitamin C on DGF, by measuring IL-18 and NGAL in living donor kidney transplantations. MATERIALS AND METHODS Patients transplanted between January 2011 and February 2013 were randomly divided into 3 groups to receive routine anti-rejection medication only (n = 32), NAC plus routine immunosuppressive regimen (NAC group; n = 33), and NAC and vitamin C plus routine regimen (NAC and vitamin C group; n = 19). Urine samples were taken 4 hours and 24 hours after transplantation....</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/66861460" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9349cc7f78beb3bc8585d9439cb244cb" rel="nofollow" data-download="{"attachment_id":77893945,"asset_id":66861460,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/77893945/download_file?st=MTczMjQwMjc5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="50823869" href="https://independent.academia.edu/JSalamzadeh">Jamshid Salamzadeh</a><script data-card-contents-for-user="50823869" type="text/json">{"id":50823869,"first_name":"Jamshid","last_name":"Salamzadeh","domain_name":"independent","page_name":"JSalamzadeh","display_name":"Jamshid Salamzadeh","profile_url":"https://independent.academia.edu/JSalamzadeh?f_ri=6970","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_66861460 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="66861460"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 66861460, container: ".js-paper-rank-work_66861460", }); 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$(".js-view-count[data-work-id=66861460]").text(description); $(".js-view-count-work_66861460").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_66861460").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="66861460"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9003" href="https://www.academia.edu/Documents/in/Kidney_transplantation">Kidney transplantation</a>, <script data-card-contents-for-ri="9003" type="text/json">{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="41274" href="https://www.academia.edu/Documents/in/Iran">Iran</a><script data-card-contents-for-ri="41274" type="text/json">{"id":41274,"name":"Iran","url":"https://www.academia.edu/Documents/in/Iran?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=66861460]'), work: {"id":66861460,"title":"Effect of N-acetyl cysteine and vitamin C on kidney allograft function biomarkers interleukin-18 and neutrophil gelatinase-associated lipocalin","created_at":"2022-01-02T08:32:30.757-08:00","url":"https://www.academia.edu/66861460/Effect_of_N_acetyl_cysteine_and_vitamin_C_on_kidney_allograft_function_biomarkers_interleukin_18_and_neutrophil_gelatinase_associated_lipocalin?f_ri=6970","dom_id":"work_66861460","summary":"INTRODUCTION Delayed graft function (DGF) is a consequence of ischemia-reperfusion injuries in kidney allografts, for which no definite treatment is available. The neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18 (IL-18) are introduced as the most promising urine biomarkers to detect DGF. N-acetylcysteine (NAC) and vitamin C, well-known potent antioxidants that scavenge free radicals, may alleviate kidney injury. This study investigated the protective effects of NAC alone and in combination with vitamin C on DGF, by measuring IL-18 and NGAL in living donor kidney transplantations. MATERIALS AND METHODS Patients transplanted between January 2011 and February 2013 were randomly divided into 3 groups to receive routine anti-rejection medication only (n = 32), NAC plus routine immunosuppressive regimen (NAC group; n = 33), and NAC and vitamin C plus routine regimen (NAC and vitamin C group; n = 19). Urine samples were taken 4 hours and 24 hours after transplantation....","downloadable_attachments":[{"id":77893945,"asset_id":66861460,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":50823869,"first_name":"Jamshid","last_name":"Salamzadeh","domain_name":"independent","page_name":"JSalamzadeh","display_name":"Jamshid Salamzadeh","profile_url":"https://independent.academia.edu/JSalamzadeh?f_ri=6970","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":9003,"name":"Kidney transplantation","url":"https://www.academia.edu/Documents/in/Kidney_transplantation?f_ri=6970","nofollow":false},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=6970","nofollow":false},{"id":41274,"name":"Iran","url":"https://www.academia.edu/Documents/in/Iran?f_ri=6970","nofollow":false},{"id":51711,"name":"Antioxidants","url":"https://www.academia.edu/Documents/in/Antioxidants?f_ri=6970"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=6970"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=6970"},{"id":205733,"name":"Allografts","url":"https://www.academia.edu/Documents/in/Allografts?f_ri=6970"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged?f_ri=6970"},{"id":352757,"name":"Ascorbic Acid","url":"https://www.academia.edu/Documents/in/Ascorbic_Acid?f_ri=6970"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult?f_ri=6970"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=6970"},{"id":572282,"name":"Combination drug therapy","url":"https://www.academia.edu/Documents/in/Combination_drug_therapy?f_ri=6970"},{"id":709138,"name":"Acute Phase Proteins","url":"https://www.academia.edu/Documents/in/Acute_Phase_Proteins?f_ri=6970"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay?f_ri=6970"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=6970"},{"id":1663285,"name":"Delayed graft function","url":"https://www.academia.edu/Documents/in/Delayed_graft_function?f_ri=6970"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin?f_ri=6970"},{"id":4061411,"name":"acetylcysteine","url":"https://www.academia.edu/Documents/in/acetylcysteine?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_66762509" data-work_id="66762509" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/66762509/The_glycolyzer_Automated_glycan_annotation_software_for_high_performance_mass_spectrometry_and_its_application_to_ovarian_cancer_glycan_biomarker_discovery">The glycolyzer: Automated glycan annotation software for high performance mass spectrometry and its application to ovarian cancer glycan biomarker discovery</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/66762509" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6ab1e1cc98a898f1b8b19f48c0dcbd14" rel="nofollow" data-download="{"attachment_id":77829164,"asset_id":66762509,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_66762509 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="66762509"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66762509; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66762509]").text(description); $(".js-view-count-work_66762509").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_66762509").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="66762509"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="428" href="https://www.academia.edu/Documents/in/Algorithms">Algorithms</a>, <script data-card-contents-for-ri="428" type="text/json">{"id":428,"name":"Algorithms","url":"https://www.academia.edu/Documents/in/Algorithms?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="5769" href="https://www.academia.edu/Documents/in/Mass_Spectrometry">Mass Spectrometry</a>, <script data-card-contents-for-ri="5769" type="text/json">{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9786" href="https://www.academia.edu/Documents/in/Proteomics">Proteomics</a><script data-card-contents-for-ri="9786" type="text/json">{"id":9786,"name":"Proteomics","url":"https://www.academia.edu/Documents/in/Proteomics?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=66762509]'), work: {"id":66762509,"title":"The glycolyzer: Automated glycan annotation software for high performance mass spectrometry and its application to ovarian cancer glycan biomarker discovery","created_at":"2022-01-01T00:10:45.781-08:00","url":"https://www.academia.edu/66762509/The_glycolyzer_Automated_glycan_annotation_software_for_high_performance_mass_spectrometry_and_its_application_to_ovarian_cancer_glycan_biomarker_discovery?f_ri=6970","dom_id":"work_66762509","summary":null,"downloadable_attachments":[{"id":77829164,"asset_id":66762509,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":20904451,"first_name":"Andres","last_name":"Guerrero","domain_name":"independent","page_name":"AndresGuerrero7","display_name":"Andres Guerrero","profile_url":"https://independent.academia.edu/AndresGuerrero7?f_ri=6970","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":428,"name":"Algorithms","url":"https://www.academia.edu/Documents/in/Algorithms?f_ri=6970","nofollow":false},{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry?f_ri=6970","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":9786,"name":"Proteomics","url":"https://www.academia.edu/Documents/in/Proteomics?f_ri=6970","nofollow":false},{"id":16061,"name":"Polysaccharides","url":"https://www.academia.edu/Documents/in/Polysaccharides?f_ri=6970"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=6970"},{"id":53293,"name":"Software","url":"https://www.academia.edu/Documents/in/Software?f_ri=6970"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970"},{"id":66379,"name":"Automation","url":"https://www.academia.edu/Documents/in/Automation?f_ri=6970"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=6970"},{"id":194916,"name":"ROC Curve","url":"https://www.academia.edu/Documents/in/ROC_Curve?f_ri=6970"},{"id":581652,"name":"Data Processing","url":"https://www.academia.edu/Documents/in/Data_Processing?f_ri=6970"},{"id":1134595,"name":"Glycomics","url":"https://www.academia.edu/Documents/in/Glycomics?f_ri=6970"},{"id":1341074,"name":"Isotope Labeling","url":"https://www.academia.edu/Documents/in/Isotope_Labeling?f_ri=6970"},{"id":3012647,"name":"Glycoproteomics","url":"https://www.academia.edu/Documents/in/Glycoproteomics?f_ri=6970"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=6970"},{"id":3881525,"name":"Ovarian Neoplasms","url":"https://www.academia.edu/Documents/in/Ovarian_Neoplasms?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_66251678" data-work_id="66251678" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/66251678/CHLOROPHYLL_a_FLUORESCENCE_AS_A_BIOMARKER_FOR_RAPID_TOXICITY_ASSESSMENT">CHLOROPHYLL a FLUORESCENCE AS A BIOMARKER FOR RAPID TOXICITY ASSESSMENT</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/66251678" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6707847b3541c21812e00e07151c1bf0" rel="nofollow" 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}); });</script></span><script>$(function() { $(".js-view-count-work_66251678").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="66251678"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2867" href="https://www.academia.edu/Documents/in/Environmental_Toxicology">Environmental Toxicology</a>, <script data-card-contents-for-ri="2867" type="text/json">{"id":2867,"name":"Environmental Toxicology","url":"https://www.academia.edu/Documents/in/Environmental_Toxicology?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="5345" href="https://www.academia.edu/Documents/in/Photosynthesis">Photosynthesis</a>, <script data-card-contents-for-ri="5345" type="text/json">{"id":5345,"name":"Photosynthesis","url":"https://www.academia.edu/Documents/in/Photosynthesis?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7698" href="https://www.academia.edu/Documents/in/Fluorescence">Fluorescence</a><script data-card-contents-for-ri="7698" type="text/json">{"id":7698,"name":"Fluorescence","url":"https://www.academia.edu/Documents/in/Fluorescence?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=66251678]'), work: {"id":66251678,"title":"CHLOROPHYLL a FLUORESCENCE AS A BIOMARKER FOR RAPID TOXICITY ASSESSMENT","created_at":"2021-12-28T12:13:07.814-08:00","url":"https://www.academia.edu/66251678/CHLOROPHYLL_a_FLUORESCENCE_AS_A_BIOMARKER_FOR_RAPID_TOXICITY_ASSESSMENT?f_ri=6970","dom_id":"work_66251678","summary":null,"downloadable_attachments":[{"id":77516556,"asset_id":66251678,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":52166617,"first_name":"Alastair","last_name":"Grant","domain_name":"independent","page_name":"GrantAlastair","display_name":"Alastair Grant","profile_url":"https://independent.academia.edu/GrantAlastair?f_ri=6970","photo":"https://0.academia-photos.com/52166617/24589247/23472147/s65_alastair.grant.jpg"}],"research_interests":[{"id":2867,"name":"Environmental Toxicology","url":"https://www.academia.edu/Documents/in/Environmental_Toxicology?f_ri=6970","nofollow":false},{"id":5345,"name":"Photosynthesis","url":"https://www.academia.edu/Documents/in/Photosynthesis?f_ri=6970","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":7698,"name":"Fluorescence","url":"https://www.academia.edu/Documents/in/Fluorescence?f_ri=6970","nofollow":false},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=6970"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=6970"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=6970"},{"id":58054,"name":"Environmental Sciences","url":"https://www.academia.edu/Documents/in/Environmental_Sciences?f_ri=6970"},{"id":85564,"name":"Chlorophyll","url":"https://www.academia.edu/Documents/in/Chlorophyll?f_ri=6970"},{"id":156160,"name":"Pulse Amplitude Modulation","url":"https://www.academia.edu/Documents/in/Pulse_Amplitude_Modulation?f_ri=6970"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES?f_ri=6970"},{"id":465928,"name":"Chlorophyll a Fluorescence","url":"https://www.academia.edu/Documents/in/Chlorophyll_a_Fluorescence?f_ri=6970"},{"id":666927,"name":"Toxicity Tests","url":"https://www.academia.edu/Documents/in/Toxicity_Tests?f_ri=6970"},{"id":882010,"name":"Environmental Toxicology and Chemistry","url":"https://www.academia.edu/Documents/in/Environmental_Toxicology_and_Chemistry?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_62464008" data-work_id="62464008" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/62464008/Dual_Inhibition_of_MEK_and_PI3K_Akt_Rescues_Cancer_Cachexia_through_Both_Tumor_Extrinsic_and_Intrinsic_Activities">Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through Both Tumor Extrinsic and Intrinsic Activities</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Involuntary weight loss, a part of the cachexia syndrome, is a debilitating co-morbidity of cancer and currently has no treatment options. Results from a recent clinical trial at our institution showed that biliary tract cancer patients... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_62464008" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Involuntary weight loss, a part of the cachexia syndrome, is a debilitating co-morbidity of cancer and currently has no treatment options. Results from a recent clinical trial at our institution showed that biliary tract cancer patients treated with a MEK inhibitor exhibited poor tumor responses, but surprisingly gained weight and increased their skeletal muscle mass. This implied that MEK inhibition might be anti-cachectic. To test this potential effect of MEK inhibition, we utilized the established Colon-26 model of cancer cachexia and the MEK½ inhibitor MEK162. Results showed that MEK inhibition effectively prevented muscle wasting. Importantly, MEK162 retained its ability to spare muscle loss even in mice bearing a Colon-26 clone resistant to the MEK inhibitor, demonstrating that the effects of blocking MEK is at least in part independent of the tumor. Because single agent MEK inhibitors have been limited as a front-line targeted therapy due to compensatory activation of other o...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/62464008" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="082c6330182b7abfaecbdce069052f08" rel="nofollow" data-download="{"attachment_id":75219207,"asset_id":62464008,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/75219207/download_file?st=MTczMjQwMjc5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="44516105" href="https://independent.academia.edu/AltonFarris">Alton Farris</a><script data-card-contents-for-user="44516105" type="text/json">{"id":44516105,"first_name":"Alton","last_name":"Farris","domain_name":"independent","page_name":"AltonFarris","display_name":"Alton Farris","profile_url":"https://independent.academia.edu/AltonFarris?f_ri=6970","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_62464008 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="62464008"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 62464008, container: ".js-paper-rank-work_62464008", }); 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Results from a recent clinical trial at our institution showed that biliary tract cancer patients treated with a MEK inhibitor exhibited poor tumor responses, but surprisingly gained weight and increased their skeletal muscle mass. This implied that MEK inhibition might be anti-cachectic. To test this potential effect of MEK inhibition, we utilized the established Colon-26 model of cancer cachexia and the MEK½ inhibitor MEK162. Results showed that MEK inhibition effectively prevented muscle wasting. Importantly, MEK162 retained its ability to spare muscle loss even in mice bearing a Colon-26 clone resistant to the MEK inhibitor, demonstrating that the effects of blocking MEK is at least in part independent of the tumor. Because single agent MEK inhibitors have been limited as a front-line targeted therapy due to compensatory activation of other o...","downloadable_attachments":[{"id":75219207,"asset_id":62464008,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":44516105,"first_name":"Alton","last_name":"Farris","domain_name":"independent","page_name":"AltonFarris","display_name":"Alton Farris","profile_url":"https://independent.academia.edu/AltonFarris?f_ri=6970","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":38831,"name":"Signal 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href="https://www.academia.edu/57829599/Acquired_temperature_sensitive_paralysis_as_a_biomarker_of_declining_neuronal_function_in_aging_Drosophila">Acquired temperature-sensitive paralysis as a biomarker of declining neuronal function in aging Drosophila</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/57829599" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="d262f8619c44c033ad97c6e969c41503" rel="nofollow" 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Rogina","profile_url":"https://independent.academia.edu/Rogina?f_ri=6970","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=6970","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":9658,"name":"Locomotion","url":"https://www.academia.edu/Documents/in/Locomotion?f_ri=6970","nofollow":false},{"id":47884,"name":"Biological 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href="https://www.academia.edu/43587199/LIVER_FIBROSIS_Causes_Symptoms_Stages_and_Treatment">LIVER FIBROSIS: Causes,Symptoms,Stages and Treatment.</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Liver fibrosis is the excessive accumulation of extracellular matrix proteins, including collagen, that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_43587199" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Liver fibrosis is the excessive accumulation of extracellular matrix proteins, including collagen, that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension and often requires liver transplantation. Knowledge of the cellular and molecular events associated with the formation of liver fibrosis has greatly advanced. Activated hepatic stellate cells, portal fibroblasts, and myofibroblasts of bone marrow origin have been identified as major collagen-producing cells in the injured liver. These cells are activated by fibrogenic cytokines such as TGF-ᵝ1, angiotensin II, and leptin. Reversibility of advanced liver fibrosis in patients has been recently documented, which has encougaged researchers to continue their research for potent and safer antifibrotic drugs. Emerging antifibrotic therapies are aimed at inhibiting the accumulation of fibrogenic cells and/or preventing the deposition of extracellular matrix proteins. Although many therapeutic interventions are effective in experimental models of liver fibrosis, their efficacy and safety in humans are largely unknown.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/43587199" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7fa57d74e07101ad288cb2c08b748770" rel="nofollow" data-download="{"attachment_id":63892351,"asset_id":43587199,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/63892351/download_file?st=MTczMjQwMjc5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="163368031" href="https://independent.academia.edu/dennisiluma">Dennis Iluma</a><script data-card-contents-for-user="163368031" type="text/json">{"id":163368031,"first_name":"Dennis","last_name":"Iluma","domain_name":"independent","page_name":"dennisiluma","display_name":"Dennis Iluma","profile_url":"https://independent.academia.edu/dennisiluma?f_ri=6970","photo":"https://0.academia-photos.com/163368031/45877841/36928888/s65_dennis.iluma.jpg"}</script></span></span></li><li class="js-paper-rank-work_43587199 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="43587199"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 43587199, container: ".js-paper-rank-work_43587199", }); 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Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension and often requires liver transplantation. Knowledge of the cellular and molecular events associated with the formation of liver fibrosis has greatly advanced. Activated hepatic stellate cells, portal fibroblasts, and myofibroblasts of bone marrow origin have been identified as major collagen-producing cells in the injured liver. These cells are activated by fibrogenic cytokines such as TGF-ᵝ1, angiotensin II, and leptin. Reversibility of advanced liver fibrosis in patients has been recently documented, which has encougaged researchers to continue their research for potent and safer antifibrotic drugs. Emerging antifibrotic therapies are aimed at inhibiting the accumulation of fibrogenic cells and/or preventing the deposition of extracellular matrix proteins. 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href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="38831" href="https://www.academia.edu/Documents/in/Signal_Transduction">Signal Transduction</a>, <script data-card-contents-for-ri="38831" type="text/json">{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="96098" 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The purpose of this study was to investigate whether autoan-tibodies against human AQP5 are present in the sera of SS patients.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21852872" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The pathophysiology of exocrine dysfunction observed in Sjögren's syndrome (SS) is not fully understood. The purpose of this study was to investigate whether autoan-tibodies against human AQP5 are present in the sera of SS patients. Frozen sections of mouse submandibular salivary glands, CHO cells over-expressing a human AQP5–GFP fusion protein or GFP, and MDCK cells over-expressing AQP5 were used in the indirect immunofluorescence assay to detect anti-AQP5 autoantibodies in the sera from patients with primary SS. The lysates of HEK-293 cells over-expressing the AQP5–GFP fusion protein or GFP were used for immuno-precipitation. Serum IgG from the SS patients but not from the control subjects stained acinar cells in the mouse salivary glands, the signals of which colocalized with those of AQP5-specific antibodies. Serum IgG from the SS patients also selectively stained AQP5–GFP expressed in CHO cells. However, both the control and SS sera immunoprecipitated the AQP5–GFP, suggesting that autoantibodies against AQP5 were also present in the control sera. The screening of 53 control and 112 SS samples by indirect immunofluorescence assay using the AQP5-expressing MDCK cells revealed the presence of significantly higher levels of anti-AQP5 IgG in the SS samples than in the control samples with sensitivity of 0.73 and a specificity of 0.68. Furthermore, the presence of anti-AQP5 autoantibodies was associated with low resting salivary flow in SS patients. In conclusion, anti-AQP5 autoantibodies were detected in the sera from SS patients, which could be a novel biomarker of SS and provide new insight into the pathogenesis of SS.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21852872" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="321b7a98eaa1972c2b941f8a78c398ab" rel="nofollow" data-download="{"attachment_id":42596566,"asset_id":21852872,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42596566/download_file?st=MTczMjQwMjc5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="4338364" href="https://snu-kr.academia.edu/JehanAlam">Jehan Alam</a><script data-card-contents-for-user="4338364" type="text/json">{"id":4338364,"first_name":"Jehan","last_name":"Alam","domain_name":"snu-kr","page_name":"JehanAlam","display_name":"Jehan Alam","profile_url":"https://snu-kr.academia.edu/JehanAlam?f_ri=6970","photo":"https://0.academia-photos.com/4338364/1743123/12880419/s65_jehan.alam.jpg"}</script></span></span></li><li class="js-paper-rank-work_21852872 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21852872"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21852872, container: ".js-paper-rank-work_21852872", }); 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$(".js-view-count[data-work-id=21852872]").text(description); $(".js-view-count-work_21852872").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_21852872").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="21852872"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">6</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="66880" href="https://www.academia.edu/Documents/in/Aquaporins_AQP_">Aquaporins (AQP)</a>, <script data-card-contents-for-ri="66880" type="text/json">{"id":66880,"name":"Aquaporins (AQP)","url":"https://www.academia.edu/Documents/in/Aquaporins_AQP_?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="431538" href="https://www.academia.edu/Documents/in/Dry_Eyes">Dry Eyes</a>, <script data-card-contents-for-ri="431538" type="text/json">{"id":431538,"name":"Dry Eyes","url":"https://www.academia.edu/Documents/in/Dry_Eyes?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="438955" href="https://www.academia.edu/Documents/in/Sjogren_s_Syndrome">Sjogren´s Syndrome</a><script data-card-contents-for-ri="438955" type="text/json">{"id":438955,"name":"Sjogren´s Syndrome","url":"https://www.academia.edu/Documents/in/Sjogren_s_Syndrome?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21852872]'), work: {"id":21852872,"title":"Detection of autoantibodies against aquaporin-5 in the sera of patients with primary Sjögren's syndrome","created_at":"2016-02-11T18:39:02.173-08:00","url":"https://www.academia.edu/21852872/Detection_of_autoantibodies_against_aquaporin_5_in_the_sera_of_patients_with_primary_Sj%C3%B6grens_syndrome?f_ri=6970","dom_id":"work_21852872","summary":"The pathophysiology of exocrine dysfunction observed in Sjögren's syndrome (SS) is not fully understood. The purpose of this study was to investigate whether autoan-tibodies against human AQP5 are present in the sera of SS patients. Frozen sections of mouse submandibular salivary glands, CHO cells over-expressing a human AQP5–GFP fusion protein or GFP, and MDCK cells over-expressing AQP5 were used in the indirect immunofluorescence assay to detect anti-AQP5 autoantibodies in the sera from patients with primary SS. The lysates of HEK-293 cells over-expressing the AQP5–GFP fusion protein or GFP were used for immuno-precipitation. Serum IgG from the SS patients but not from the control subjects stained acinar cells in the mouse salivary glands, the signals of which colocalized with those of AQP5-specific antibodies. Serum IgG from the SS patients also selectively stained AQP5–GFP expressed in CHO cells. However, both the control and SS sera immunoprecipitated the AQP5–GFP, suggesting that autoantibodies against AQP5 were also present in the control sera. The screening of 53 control and 112 SS samples by indirect immunofluorescence assay using the AQP5-expressing MDCK cells revealed the presence of significantly higher levels of anti-AQP5 IgG in the SS samples than in the control samples with sensitivity of 0.73 and a specificity of 0.68. Furthermore, the presence of anti-AQP5 autoantibodies was associated with low resting salivary flow in SS patients. In conclusion, anti-AQP5 autoantibodies were detected in the sera from SS patients, which could be a novel biomarker of SS and provide new insight into the pathogenesis of SS.","downloadable_attachments":[{"id":42596566,"asset_id":21852872,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":4338364,"first_name":"Jehan","last_name":"Alam","domain_name":"snu-kr","page_name":"JehanAlam","display_name":"Jehan Alam","profile_url":"https://snu-kr.academia.edu/JehanAlam?f_ri=6970","photo":"https://0.academia-photos.com/4338364/1743123/12880419/s65_jehan.alam.jpg"}],"research_interests":[{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":66880,"name":"Aquaporins (AQP)","url":"https://www.academia.edu/Documents/in/Aquaporins_AQP_?f_ri=6970","nofollow":false},{"id":431538,"name":"Dry Eyes","url":"https://www.academia.edu/Documents/in/Dry_Eyes?f_ri=6970","nofollow":false},{"id":438955,"name":"Sjogren´s Syndrome","url":"https://www.academia.edu/Documents/in/Sjogren_s_Syndrome?f_ri=6970","nofollow":false},{"id":1482586,"name":"Autoantibodies","url":"https://www.academia.edu/Documents/in/Autoantibodies?f_ri=6970"},{"id":1669329,"name":"Dry mouth","url":"https://www.academia.edu/Documents/in/Dry_mouth?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18837177" data-work_id="18837177" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18837177/Biomarkers_for_intensive_care_medicine_patients_the_stony_path_into_a_bright_future">Biomarkers for intensive care medicine patients: the (stony) path into a bright future?</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18837177" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="668ca6fc3d2132b1d9e2e119185de487" rel="nofollow" data-download="{"attachment_id":40282625,"asset_id":18837177,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/40282625/download_file?st=MTczMjQwMjc5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38936975" href="https://independent.academia.edu/KhusruAsadullah">Khusru Asadullah</a><script data-card-contents-for-user="38936975" type="text/json">{"id":38936975,"first_name":"Khusru","last_name":"Asadullah","domain_name":"independent","page_name":"KhusruAsadullah","display_name":"Khusru Asadullah","profile_url":"https://independent.academia.edu/KhusruAsadullah?f_ri=6970","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_18837177 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="18837177"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 18837177, container: ".js-paper-rank-work_18837177", }); 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$(".js-view-count[data-work-id=18837177]").text(description); $(".js-view-count-work_18837177").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_18837177").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="18837177"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="33760" href="https://www.academia.edu/Documents/in/Environmental_Biotechnology">Environmental Biotechnology</a>, <script data-card-contents-for-ri="33760" type="text/json">{"id":33760,"name":"Environmental Biotechnology","url":"https://www.academia.edu/Documents/in/Environmental_Biotechnology?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="94234" href="https://www.academia.edu/Documents/in/INTENSIVE_CARE">INTENSIVE CARE</a><script data-card-contents-for-ri="94234" type="text/json">{"id":94234,"name":"INTENSIVE CARE","url":"https://www.academia.edu/Documents/in/INTENSIVE_CARE?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=18837177]'), work: {"id":18837177,"title":"Biomarkers for intensive care medicine patients: the (stony) path into a bright future?","created_at":"2015-11-22T23:00:16.530-08:00","url":"https://www.academia.edu/18837177/Biomarkers_for_intensive_care_medicine_patients_the_stony_path_into_a_bright_future?f_ri=6970","dom_id":"work_18837177","summary":null,"downloadable_attachments":[{"id":40282625,"asset_id":18837177,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38936975,"first_name":"Khusru","last_name":"Asadullah","domain_name":"independent","page_name":"KhusruAsadullah","display_name":"Khusru Asadullah","profile_url":"https://independent.academia.edu/KhusruAsadullah?f_ri=6970","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":33760,"name":"Environmental Biotechnology","url":"https://www.academia.edu/Documents/in/Environmental_Biotechnology?f_ri=6970","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970","nofollow":false},{"id":94234,"name":"INTENSIVE CARE","url":"https://www.academia.edu/Documents/in/INTENSIVE_CARE?f_ri=6970","nofollow":false},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_73198423" data-work_id="73198423" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/73198423/Lipoprotein_a_and_Increased_Cardiovascular_Risk_in_Women">Lipoprotein(a) and Increased Cardiovascular Risk in Women</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Approximately 20% of the population has elevated circulating levels of lipoprotein(a) (Lp[a]), one of the most robust predictors of cardiovascular disease risk. This is particularly true for women. Many female patients with... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_73198423" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Approximately 20% of the population has elevated circulating levels of lipoprotein(a) (Lp[a]), one of the most robust predictors of cardiovascular disease risk. This is particularly true for women. Many female patients with &quot;normal&quot; traditional risk factors or low atherosclerotic cardiovascular disease (ASCVD) risk scores may harbor high risk related to elevated levels of Lp(a). A retrospective, cross-sectional study of consecutive female patients presenting to Heart Centers for Women was performed. Discordance between low-density lipoprotein cholesterol (LDL-C) and Lp(a) was determined. The ASCVD risk and Reynolds Risk Score models A (RRS-A) and B (RRS-B) were calculated, and level of agreement in patients meeting treatment threshold (≥7.5% for ASCVD, ≥10% for RRS-A and RRS-B) were compared. Among 713 women, 290 (41%) had elevated Lp(a); however, LDL-C and Lp(a) were weakly correlated (r = 0.08). Significant discordance was observed between abnormal LDL-C and Lp(a) levels...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/73198423" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9fd89bd9a1b308375fb41934a512d30c" rel="nofollow" data-download="{"attachment_id":81811291,"asset_id":73198423,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/81811291/download_file?st=MTczMjQwMjc5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="206460235" href="https://independent.academia.edu/BraunLynne">Lynne Braun</a><script data-card-contents-for-user="206460235" type="text/json">{"id":206460235,"first_name":"Lynne","last_name":"Braun","domain_name":"independent","page_name":"BraunLynne","display_name":"Lynne Braun","profile_url":"https://independent.academia.edu/BraunLynne?f_ri=6970","photo":"https://0.academia-photos.com/206460235/66858841/55217350/s65_lynne.braun.png"}</script></span></span></li><li class="js-paper-rank-work_73198423 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="73198423"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 73198423, container: ".js-paper-rank-work_73198423", }); });</script></li><li class="js-percentile-work_73198423 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73198423; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_73198423"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_73198423 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="73198423"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73198423; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73198423]").text(description); $(".js-view-count-work_73198423").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_73198423").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="73198423"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="16664" href="https://www.academia.edu/Documents/in/Risk_assessment">Risk assessment</a>, <script data-card-contents-for-ri="16664" type="text/json">{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="33668" href="https://www.academia.edu/Documents/in/Georgia">Georgia</a><script data-card-contents-for-ri="33668" type="text/json">{"id":33668,"name":"Georgia","url":"https://www.academia.edu/Documents/in/Georgia?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=73198423]'), work: {"id":73198423,"title":"Lipoprotein(a) and Increased Cardiovascular Risk in Women","created_at":"2022-03-06T13:33:37.067-08:00","url":"https://www.academia.edu/73198423/Lipoprotein_a_and_Increased_Cardiovascular_Risk_in_Women?f_ri=6970","dom_id":"work_73198423","summary":"Approximately 20% of the population has elevated circulating levels of lipoprotein(a) (Lp[a]), one of the most robust predictors of cardiovascular disease risk. This is particularly true for women. Many female patients with \u0026quot;normal\u0026quot; traditional risk factors or low atherosclerotic cardiovascular disease (ASCVD) risk scores may harbor high risk related to elevated levels of Lp(a). A retrospective, cross-sectional study of consecutive female patients presenting to Heart Centers for Women was performed. Discordance between low-density lipoprotein cholesterol (LDL-C) and Lp(a) was determined. The ASCVD risk and Reynolds Risk Score models A (RRS-A) and B (RRS-B) were calculated, and level of agreement in patients meeting treatment threshold (≥7.5% for ASCVD, ≥10% for RRS-A and RRS-B) were compared. Among 713 women, 290 (41%) had elevated Lp(a); however, LDL-C and Lp(a) were weakly correlated (r = 0.08). Significant discordance was observed between abnormal LDL-C and Lp(a) levels...","downloadable_attachments":[{"id":81811291,"asset_id":73198423,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":206460235,"first_name":"Lynne","last_name":"Braun","domain_name":"independent","page_name":"BraunLynne","display_name":"Lynne Braun","profile_url":"https://independent.academia.edu/BraunLynne?f_ri=6970","photo":"https://0.academia-photos.com/206460235/66858841/55217350/s65_lynne.braun.png"}],"research_interests":[{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":16664,"name":"Risk assessment","url":"https://www.academia.edu/Documents/in/Risk_assessment?f_ri=6970","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=6970","nofollow":false},{"id":33668,"name":"Georgia","url":"https://www.academia.edu/Documents/in/Georgia?f_ri=6970","nofollow":false},{"id":41154,"name":"Chicago","url":"https://www.academia.edu/Documents/in/Chicago?f_ri=6970"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=6970"},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=6970"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=6970"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=6970"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged?f_ri=6970"},{"id":413192,"name":"Sex Factors","url":"https://www.academia.edu/Documents/in/Sex_Factors?f_ri=6970"},{"id":464030,"name":"Clinical Cardiology","url":"https://www.academia.edu/Documents/in/Clinical_Cardiology?f_ri=6970"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=6970"},{"id":559242,"name":"Cardiovascular Diseases","url":"https://www.academia.edu/Documents/in/Cardiovascular_Diseases?f_ri=6970"},{"id":620049,"name":"Risk Factors","url":"https://www.academia.edu/Documents/in/Risk_Factors-1?f_ri=6970"},{"id":622589,"name":"Risk Assessment","url":"https://www.academia.edu/Documents/in/Risk_Assessment-2?f_ri=6970"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies?f_ri=6970"},{"id":1371154,"name":"Lipoprotein a","url":"https://www.academia.edu/Documents/in/Lipoprotein_a?f_ri=6970"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_70709435" data-work_id="70709435" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/70709435/Usefulness_of_genetic_susceptibility_and_biomarkers_for_evaluation_of_environmental_health_risk">Usefulness of genetic susceptibility and biomarkers for evaluation of environmental health risk</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Recent attention is focused on understanding the genetic basis for individual susceptibility to the development of chronic disease. An emphasis is concentrated on establishing an association be-tween inheritance of polymorphic chemical... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_70709435" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Recent attention is focused on understanding the genetic basis for individual susceptibility to the development of chronic disease. An emphasis is concentrated on establishing an association be-tween inheritance of polymorphic chemical metab-olizing genes and development of ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/70709435" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="133890940" href="https://independent.academia.edu/SalamaSalama17">Salama Salama</a><script data-card-contents-for-user="133890940" type="text/json">{"id":133890940,"first_name":"Salama","last_name":"Salama","domain_name":"independent","page_name":"SalamaSalama17","display_name":"Salama Salama","profile_url":"https://independent.academia.edu/SalamaSalama17?f_ri=6970","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_70709435 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="70709435"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 70709435, container: ".js-paper-rank-work_70709435", }); 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$(".js-view-count[data-work-id=70709435]").text(description); $(".js-view-count-work_70709435").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_70709435").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="70709435"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3058" href="https://www.academia.edu/Documents/in/Biostatistics">Biostatistics</a>, <script data-card-contents-for-ri="3058" type="text/json">{"id":3058,"name":"Biostatistics","url":"https://www.academia.edu/Documents/in/Biostatistics?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7403" href="https://www.academia.edu/Documents/in/Environmental_Health">Environmental Health</a>, <script data-card-contents-for-ri="7403" type="text/json">{"id":7403,"name":"Environmental Health","url":"https://www.academia.edu/Documents/in/Environmental_Health?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7710" href="https://www.academia.edu/Documents/in/Biology">Biology</a><script data-card-contents-for-ri="7710" type="text/json">{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=70709435]'), work: {"id":70709435,"title":"Usefulness of genetic susceptibility and biomarkers for evaluation of environmental health risk","created_at":"2022-02-06T07:41:49.682-08:00","url":"https://www.academia.edu/70709435/Usefulness_of_genetic_susceptibility_and_biomarkers_for_evaluation_of_environmental_health_risk?f_ri=6970","dom_id":"work_70709435","summary":"Recent attention is focused on understanding the genetic basis for individual susceptibility to the development of chronic disease. An emphasis is concentrated on establishing an association be-tween inheritance of polymorphic chemical metab-olizing genes and development of ...","downloadable_attachments":[],"ordered_authors":[{"id":133890940,"first_name":"Salama","last_name":"Salama","domain_name":"independent","page_name":"SalamaSalama17","display_name":"Salama Salama","profile_url":"https://independent.academia.edu/SalamaSalama17?f_ri=6970","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":3058,"name":"Biostatistics","url":"https://www.academia.edu/Documents/in/Biostatistics?f_ri=6970","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":7403,"name":"Environmental Health","url":"https://www.academia.edu/Documents/in/Environmental_Health?f_ri=6970","nofollow":false},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=6970","nofollow":false},{"id":8270,"name":"Forecasting","url":"https://www.academia.edu/Documents/in/Forecasting?f_ri=6970"},{"id":21747,"name":"Experimental Design","url":"https://www.academia.edu/Documents/in/Experimental_Design?f_ri=6970"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=6970"},{"id":58054,"name":"Environmental Sciences","url":"https://www.academia.edu/Documents/in/Environmental_Sciences?f_ri=6970"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970"},{"id":437728,"name":"Isoenzymes","url":"https://www.academia.edu/Documents/in/Isoenzymes?f_ri=6970"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers?f_ri=6970"},{"id":577933,"name":"Genetic variation","url":"https://www.academia.edu/Documents/in/Genetic_variation?f_ri=6970"},{"id":686495,"name":"Esterases","url":"https://www.academia.edu/Documents/in/Esterases?f_ri=6970"},{"id":700335,"name":"Glutathione Transferase","url":"https://www.academia.edu/Documents/in/Glutathione_Transferase?f_ri=6970"},{"id":1133132,"name":"Environmental","url":"https://www.academia.edu/Documents/in/Environmental?f_ri=6970"},{"id":1153872,"name":"Genetic Susceptibility","url":"https://www.academia.edu/Documents/in/Genetic_Susceptibility?f_ri=6970"},{"id":1208706,"name":"Environment","url":"https://www.academia.edu/Documents/in/Environment?f_ri=6970"},{"id":2518519,"name":"health status indicators","url":"https://www.academia.edu/Documents/in/health_status_indicators?f_ri=6970"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=6970"},{"id":3840853,"name":"lung neoplasms","url":"https://www.academia.edu/Documents/in/lung_neoplasms?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_64907419" data-work_id="64907419" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/64907419/Human_Health_Effects_from_Cadmium_Exposure_Comparison_Between_Persons_Living_in_Cadmium_Contaminated_and_Non_Contaminated_Areas_in_Northwestern_Thailand">Human Health Effects from Cadmium Exposure: Comparison Between Persons Living in Cadmium-Contaminated and Non-Contaminated Areas in Northwestern Thailand</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Environmental cadmium contamination is present in some rural villages of Mae Sot District, Tak Province, northwestern Thailand. We compared the health of 751 persons aged ≥ 35 years living in 3 contaminated villages with 682 people from 3... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_64907419" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Environmental cadmium contamination is present in some rural villages of Mae Sot District, Tak Province, northwestern Thailand. We compared the health of 751 persons aged ≥ 35 years living in 3 contaminated villages with 682 people from 3 non-contaminated villages with similar socio-demographic and lifestyle characteristics in the same district. All the subjects were screened for urinary cadmium (a biomarker for long-term cadmium exposure), renal function, hypertension, diabetes, hypercholesterolemia, hypertriglyceridemia, urinary tract stone disease and bone mineral density in 2012. The study renal functions included urinary excretion of β2-microglobulin (early tubular effect), total urine protein and glomerular filtration rate (glomerular effects). The geometric mean of urinary cadmium level was significantly higher among persons living in the contaminated areas (2.96 μg/g creatinine) than those in the non-contaminated areas (0.60 μg/g creatinine). Persons living in contaminated a...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/64907419" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="331aa16ecb88dec1744bfab80d7150bf" rel="nofollow" data-download="{"attachment_id":76723418,"asset_id":64907419,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/76723418/download_file?st=MTczMjQwMjc5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38092699" href="https://independent.academia.edu/WitayaSwaddiwudhipong">Witaya Swaddiwudhipong</a><script data-card-contents-for-user="38092699" type="text/json">{"id":38092699,"first_name":"Witaya","last_name":"Swaddiwudhipong","domain_name":"independent","page_name":"WitayaSwaddiwudhipong","display_name":"Witaya Swaddiwudhipong","profile_url":"https://independent.academia.edu/WitayaSwaddiwudhipong?f_ri=6970","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_64907419 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="64907419"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 64907419, container: ".js-paper-rank-work_64907419", }); });</script></li><li class="js-percentile-work_64907419 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 64907419; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_64907419"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_64907419 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="64907419"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 64907419; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=64907419]").text(description); $(".js-view-count-work_64907419").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_64907419").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="64907419"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10096" href="https://www.academia.edu/Documents/in/Thailand">Thailand</a>, <script data-card-contents-for-ri="10096" type="text/json">{"id":10096,"name":"Thailand","url":"https://www.academia.edu/Documents/in/Thailand?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a>, <script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="71399" href="https://www.academia.edu/Documents/in/Hypertension">Hypertension</a><script data-card-contents-for-ri="71399" type="text/json">{"id":71399,"name":"Hypertension","url":"https://www.academia.edu/Documents/in/Hypertension?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=64907419]'), work: {"id":64907419,"title":"Human Health Effects from Cadmium Exposure: Comparison Between Persons Living in Cadmium-Contaminated and Non-Contaminated Areas in Northwestern Thailand","created_at":"2021-12-17T15:05:23.245-08:00","url":"https://www.academia.edu/64907419/Human_Health_Effects_from_Cadmium_Exposure_Comparison_Between_Persons_Living_in_Cadmium_Contaminated_and_Non_Contaminated_Areas_in_Northwestern_Thailand?f_ri=6970","dom_id":"work_64907419","summary":"Environmental cadmium contamination is present in some rural villages of Mae Sot District, Tak Province, northwestern Thailand. We compared the health of 751 persons aged ≥ 35 years living in 3 contaminated villages with 682 people from 3 non-contaminated villages with similar socio-demographic and lifestyle characteristics in the same district. All the subjects were screened for urinary cadmium (a biomarker for long-term cadmium exposure), renal function, hypertension, diabetes, hypercholesterolemia, hypertriglyceridemia, urinary tract stone disease and bone mineral density in 2012. The study renal functions included urinary excretion of β2-microglobulin (early tubular effect), total urine protein and glomerular filtration rate (glomerular effects). The geometric mean of urinary cadmium level was significantly higher among persons living in the contaminated areas (2.96 μg/g creatinine) than those in the non-contaminated areas (0.60 μg/g creatinine). Persons living in contaminated a...","downloadable_attachments":[{"id":76723418,"asset_id":64907419,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38092699,"first_name":"Witaya","last_name":"Swaddiwudhipong","domain_name":"independent","page_name":"WitayaSwaddiwudhipong","display_name":"Witaya Swaddiwudhipong","profile_url":"https://independent.academia.edu/WitayaSwaddiwudhipong?f_ri=6970","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":10096,"name":"Thailand","url":"https://www.academia.edu/Documents/in/Thailand?f_ri=6970","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970","nofollow":false},{"id":71399,"name":"Hypertension","url":"https://www.academia.edu/Documents/in/Hypertension?f_ri=6970","nofollow":false},{"id":71511,"name":"Diabetes mellitus","url":"https://www.academia.edu/Documents/in/Diabetes_mellitus?f_ri=6970"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=6970"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=6970"},{"id":213907,"name":"Cadmium","url":"https://www.academia.edu/Documents/in/Cadmium?f_ri=6970"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=6970"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=6970"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged?f_ri=6970"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult?f_ri=6970"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=6970"},{"id":1312021,"name":"Environmental Exposure","url":"https://www.academia.edu/Documents/in/Environmental_Exposure?f_ri=6970"},{"id":1438730,"name":"Creatinine","url":"https://www.academia.edu/Documents/in/Creatinine?f_ri=6970"},{"id":2366663,"name":"Glomerular Filtration Rate","url":"https://www.academia.edu/Documents/in/Glomerular_Filtration_Rate?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_59117385" data-work_id="59117385" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/59117385/Physical_activity_patterns_and_biomarkers_of_cardiovascular_disease_risk_in_hunter_gatherers">Physical activity patterns and biomarkers of cardiovascular disease risk in hunter-gatherers</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Time spent in moderate-to-vigorous physical activity (MVPA) is a strong predictor of cardiovascular health, yet few humans living in industrialized societies meet current recommendations (150 min/week). Researchers have long suggested... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_59117385" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Time spent in moderate-to-vigorous physical activity (MVPA) is a strong predictor of cardiovascular health, yet few humans living in industrialized societies meet current recommendations (150 min/week). Researchers have long suggested that human physiological requirements for aerobic exercise reflect an evolutionary shift to a hunting and gathering foraging strategy, and a recent transition to more sedentary lifestyles likely represents a mismatch with our past in terms of physical activity. The goal of this study is to explore this mismatch by characterizing MVPA and cardiovascular health in the Hadza, a modern hunting and gathering population living in Northern Tanzania. We measured MVPA using continuous heart rate monitoring in 46 participants recruited from two Hadza camps. As part of a larger survey of health in the Hadza, we measured blood pressure (n = 198) and biomarkers of cardiovascular health (n = 23) including C-reactive protein, cholesterol (Total, HDL, and LDL), and tr...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/59117385" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b36e243658a95bd428ed207323fc6665" rel="nofollow" data-download="{"attachment_id":73204644,"asset_id":59117385,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/73204644/download_file?st=MTczMjQwMjc5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="16613507" href="https://independent.academia.edu/AudaxMabulla">Audax Mabulla</a><script data-card-contents-for-user="16613507" type="text/json">{"id":16613507,"first_name":"Audax","last_name":"Mabulla","domain_name":"independent","page_name":"AudaxMabulla","display_name":"Audax Mabulla","profile_url":"https://independent.academia.edu/AudaxMabulla?f_ri=6970","photo":"https://0.academia-photos.com/16613507/40312446/33058510/s65_audax.mabulla.jpg"}</script></span></span></li><li class="js-paper-rank-work_59117385 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="59117385"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 59117385, container: ".js-paper-rank-work_59117385", }); 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$(".js-view-count[data-work-id=59117385]").text(description); $(".js-view-count-work_59117385").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_59117385").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="59117385"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">20</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="155" href="https://www.academia.edu/Documents/in/Evolutionary_Biology">Evolutionary Biology</a>, <script data-card-contents-for-ri="155" type="text/json">{"id":155,"name":"Evolutionary Biology","url":"https://www.academia.edu/Documents/in/Evolutionary_Biology?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="591" href="https://www.academia.edu/Documents/in/Nutrition_and_Dietetics">Nutrition and Dietetics</a>, <script data-card-contents-for-ri="591" type="text/json">{"id":591,"name":"Nutrition and Dietetics","url":"https://www.academia.edu/Documents/in/Nutrition_and_Dietetics?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="767" href="https://www.academia.edu/Documents/in/Anthropology">Anthropology</a>, <script data-card-contents-for-ri="767" type="text/json">{"id":767,"name":"Anthropology","url":"https://www.academia.edu/Documents/in/Anthropology?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a><script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=59117385]'), work: {"id":59117385,"title":"Physical activity patterns and biomarkers of cardiovascular disease risk in hunter-gatherers","created_at":"2021-10-20T07:07:49.987-07:00","url":"https://www.academia.edu/59117385/Physical_activity_patterns_and_biomarkers_of_cardiovascular_disease_risk_in_hunter_gatherers?f_ri=6970","dom_id":"work_59117385","summary":"Time spent in moderate-to-vigorous physical activity (MVPA) is a strong predictor of cardiovascular health, yet few humans living in industrialized societies meet current recommendations (150 min/week). Researchers have long suggested that human physiological requirements for aerobic exercise reflect an evolutionary shift to a hunting and gathering foraging strategy, and a recent transition to more sedentary lifestyles likely represents a mismatch with our past in terms of physical activity. The goal of this study is to explore this mismatch by characterizing MVPA and cardiovascular health in the Hadza, a modern hunting and gathering population living in Northern Tanzania. We measured MVPA using continuous heart rate monitoring in 46 participants recruited from two Hadza camps. As part of a larger survey of health in the Hadza, we measured blood pressure (n = 198) and biomarkers of cardiovascular health (n = 23) including C-reactive protein, cholesterol (Total, HDL, and LDL), and tr...","downloadable_attachments":[{"id":73204644,"asset_id":59117385,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":16613507,"first_name":"Audax","last_name":"Mabulla","domain_name":"independent","page_name":"AudaxMabulla","display_name":"Audax Mabulla","profile_url":"https://independent.academia.edu/AudaxMabulla?f_ri=6970","photo":"https://0.academia-photos.com/16613507/40312446/33058510/s65_audax.mabulla.jpg"}],"research_interests":[{"id":155,"name":"Evolutionary Biology","url":"https://www.academia.edu/Documents/in/Evolutionary_Biology?f_ri=6970","nofollow":false},{"id":591,"name":"Nutrition and 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href="https://www.academia.edu/55716644/Dual_energy_computed_tomography_as_a_diagnostic_tool_for_gout_during_intercritical_periods">Dual-energy computed tomography as a diagnostic tool for gout during intercritical periods</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/55716644" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4167cd04fa037474754a752a64fba745" rel="nofollow" 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Acid","url":"https://www.academia.edu/Documents/in/Uric_Acid?f_ri=6970"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult?f_ri=6970"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies?f_ri=6970"},{"id":612098,"name":"Gout","url":"https://www.academia.edu/Documents/in/Gout?f_ri=6970"},{"id":670043,"name":"Joints","url":"https://www.academia.edu/Documents/in/Joints?f_ri=6970"},{"id":672296,"name":"Rheumatic diseases","url":"https://www.academia.edu/Documents/in/Rheumatic_diseases?f_ri=6970"},{"id":959921,"name":"X ray Computed Tomography","url":"https://www.academia.edu/Documents/in/X_ray_Computed_Tomography?f_ri=6970"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=6970"},{"id":3609931,"name":"Asymptomatic Diseases.","url":"https://www.academia.edu/Documents/in/Asymptomatic_Diseases?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_53666222" data-work_id="53666222" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/53666222/Increased_galectin_3_may_serve_as_a_serologic_signature_of_pre_rheumatoid_arthritis_while_markers_of_synovitis_and_cartilage_do_not_differ_between_early_undifferentiated_arthritis_subsets">Increased galectin-3 may serve as a serologic signature of pre-rheumatoid arthritis while markers of synovitis and cartilage do not differ between early undifferentiated arthritis subsets</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Undifferentiated arthritis (UA) is a label applied to patients with joint complaints which cannot be classified according to current criteria, which implies a need for precision diagnostic technologies. We studied serum galectin-3, a... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_53666222" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Undifferentiated arthritis (UA) is a label applied to patients with joint complaints which cannot be classified according to current criteria, which implies a need for precision diagnostic technologies. We studied serum galectin-3, a proinflammatory mediator, and seromarkers of structural joint elements in patients with early, UA and their associations with disease profile and biochemical and imaging findings. One hundred and eleven UA patients were followed-up for at least 12 months and reclassified according to appropriate criteria (TUDAR). At baseline, demographics and laboratory and clinical disease measures, as well as wrist magnetic resonance imaging (MRI) synovitis, erosion, and bone marrow edema scorings, were recorded. Galectin-3, the type IIA collagen N-terminal propeptide (PIIANP), which is a marker of regenerative cartilage formation, and hyaluronan (HYA), which is prevalent in synovial tissue swellings, were measured by enzyme-linked immunosorbent assay (ELISA). Receive...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/53666222" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c593680bf8cd8f5b23b3b01b17cfc235" rel="nofollow" data-download="{"attachment_id":70403704,"asset_id":53666222,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/70403704/download_file?st=MTczMjQwMjc5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="40564096" href="https://ku-dk.academia.edu/MereteHetland">Merete Hetland</a><script data-card-contents-for-user="40564096" type="text/json">{"id":40564096,"first_name":"Merete","last_name":"Hetland","domain_name":"ku-dk","page_name":"MereteHetland","display_name":"Merete Hetland","profile_url":"https://ku-dk.academia.edu/MereteHetland?f_ri=6970","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_53666222 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="53666222"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 53666222, container: ".js-paper-rank-work_53666222", }); 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$(".js-view-count[data-work-id=53666222]").text(description); $(".js-view-count-work_53666222").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_53666222").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="53666222"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">17</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="12733" href="https://www.academia.edu/Documents/in/Rheumatoid_Arthritis">Rheumatoid Arthritis</a>, <script data-card-contents-for-ri="12733" type="text/json">{"id":12733,"name":"Rheumatoid Arthritis","url":"https://www.academia.edu/Documents/in/Rheumatoid_Arthritis?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a><script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=53666222]'), work: {"id":53666222,"title":"Increased galectin-3 may serve as a serologic signature of pre-rheumatoid arthritis while markers of synovitis and cartilage do not differ between early undifferentiated arthritis subsets","created_at":"2021-09-28T03:17:44.593-07:00","url":"https://www.academia.edu/53666222/Increased_galectin_3_may_serve_as_a_serologic_signature_of_pre_rheumatoid_arthritis_while_markers_of_synovitis_and_cartilage_do_not_differ_between_early_undifferentiated_arthritis_subsets?f_ri=6970","dom_id":"work_53666222","summary":"Undifferentiated arthritis (UA) is a label applied to patients with joint complaints which cannot be classified according to current criteria, which implies a need for precision diagnostic technologies. We studied serum galectin-3, a proinflammatory mediator, and seromarkers of structural joint elements in patients with early, UA and their associations with disease profile and biochemical and imaging findings. One hundred and eleven UA patients were followed-up for at least 12 months and reclassified according to appropriate criteria (TUDAR). At baseline, demographics and laboratory and clinical disease measures, as well as wrist magnetic resonance imaging (MRI) synovitis, erosion, and bone marrow edema scorings, were recorded. Galectin-3, the type IIA collagen N-terminal propeptide (PIIANP), which is a marker of regenerative cartilage formation, and hyaluronan (HYA), which is prevalent in synovial tissue swellings, were measured by enzyme-linked immunosorbent assay (ELISA). Receive...","downloadable_attachments":[{"id":70403704,"asset_id":53666222,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":40564096,"first_name":"Merete","last_name":"Hetland","domain_name":"ku-dk","page_name":"MereteHetland","display_name":"Merete Hetland","profile_url":"https://ku-dk.academia.edu/MereteHetland?f_ri=6970","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=6970","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":12733,"name":"Rheumatoid Arthritis","url":"https://www.academia.edu/Documents/in/Rheumatoid_Arthritis?f_ri=6970","nofollow":false},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=6970","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970"},{"id":78188,"name":"Cartilage","url":"https://www.academia.edu/Documents/in/Cartilage?f_ri=6970"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=6970"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=6970"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=6970"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=6970"},{"id":216687,"name":"Galectin","url":"https://www.academia.edu/Documents/in/Galectin?f_ri=6970"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=6970"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=6970"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged?f_ri=6970"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult?f_ri=6970"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=6970"},{"id":964185,"name":"Synovitis","url":"https://www.academia.edu/Documents/in/Synovitis?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_50236983" data-work_id="50236983" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/50236983/The_epigenetic_clock_is_correlated_with_physical_and_cognitive_fitness_in_the_Lothian_Birth_Cohort_1936">The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The DNA methylation-based &#39;epigenetic clock&#39; correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_50236983" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The DNA methylation-based &#39;epigenetic clock&#39; correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and four mortality-linked markers of physical and mental fitness: lung function, walking speed, grip strength and cognitive ability. DNA methylation-based age acceleration (residuals of the epigenetic clock estimate regressed on chronological age) were estimated in the Lothian Birth Cohort 1936 at ages 70 (n = 920), 73 (n = 299) and 76 (n = 273) years. General cognitive ability, walking speed, lung function and grip strength were measured concurrently. Cross-sectional correlations between age acceleration and the fitness variables were calculated. Longitudinal change in the epigenetic clock estimates and the fitness variables were assessed via linear mixed models and latent growth curves. Epigenetic age acceleration at age 70 was used as a ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/50236983" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0fbe0b43c39417f7a62f5aa02ed52fad" rel="nofollow" data-download="{"attachment_id":68297857,"asset_id":50236983,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/68297857/download_file?st=MTczMjQwMjc5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="31753110" href="https://ucl.academia.edu/GracielaMuniz">Graciela Muniz</a><script data-card-contents-for-user="31753110" type="text/json">{"id":31753110,"first_name":"Graciela","last_name":"Muniz","domain_name":"ucl","page_name":"GracielaMuniz","display_name":"Graciela Muniz","profile_url":"https://ucl.academia.edu/GracielaMuniz?f_ri=6970","photo":"https://0.academia-photos.com/31753110/33557476/29853517/s65_graciela.muniz.jpg"}</script></span></span></li><li class="js-paper-rank-work_50236983 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="50236983"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 50236983, container: ".js-paper-rank-work_50236983", }); 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$(".js-view-count[data-work-id=50236983]").text(description); $(".js-view-count-work_50236983").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_50236983").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="50236983"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">19</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="892" href="https://www.academia.edu/Documents/in/Statistics">Statistics</a>, <script data-card-contents-for-ri="892" type="text/json">{"id":892,"name":"Statistics","url":"https://www.academia.edu/Documents/in/Statistics?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1085" href="https://www.academia.edu/Documents/in/Epidemiology">Epidemiology</a>, <script data-card-contents-for-ri="1085" type="text/json">{"id":1085,"name":"Epidemiology","url":"https://www.academia.edu/Documents/in/Epidemiology?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4212" href="https://www.academia.edu/Documents/in/Cognition">Cognition</a>, <script data-card-contents-for-ri="4212" type="text/json">{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6791" href="https://www.academia.edu/Documents/in/Aging">Aging</a><script data-card-contents-for-ri="6791" type="text/json">{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=50236983]'), work: {"id":50236983,"title":"The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936","created_at":"2021-07-25T01:43:49.196-07:00","url":"https://www.academia.edu/50236983/The_epigenetic_clock_is_correlated_with_physical_and_cognitive_fitness_in_the_Lothian_Birth_Cohort_1936?f_ri=6970","dom_id":"work_50236983","summary":"The DNA methylation-based \u0026#39;epigenetic clock\u0026#39; correlates strongly with chronological age, but it is currently unclear what drives individual differences. We examine cross-sectional and longitudinal associations between the epigenetic clock and four mortality-linked markers of physical and mental fitness: lung function, walking speed, grip strength and cognitive ability. DNA methylation-based age acceleration (residuals of the epigenetic clock estimate regressed on chronological age) were estimated in the Lothian Birth Cohort 1936 at ages 70 (n = 920), 73 (n = 299) and 76 (n = 273) years. General cognitive ability, walking speed, lung function and grip strength were measured concurrently. Cross-sectional correlations between age acceleration and the fitness variables were calculated. Longitudinal change in the epigenetic clock estimates and the fitness variables were assessed via linear mixed models and latent growth curves. Epigenetic age acceleration at age 70 was used as a ...","downloadable_attachments":[{"id":68297857,"asset_id":50236983,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":31753110,"first_name":"Graciela","last_name":"Muniz","domain_name":"ucl","page_name":"GracielaMuniz","display_name":"Graciela Muniz","profile_url":"https://ucl.academia.edu/GracielaMuniz?f_ri=6970","photo":"https://0.academia-photos.com/31753110/33557476/29853517/s65_graciela.muniz.jpg"}],"research_interests":[{"id":892,"name":"Statistics","url":"https://www.academia.edu/Documents/in/Statistics?f_ri=6970","nofollow":false},{"id":1085,"name":"Epidemiology","url":"https://www.academia.edu/Documents/in/Epidemiology?f_ri=6970","nofollow":false},{"id":4212,"name":"Cognition","url":"https://www.academia.edu/Documents/in/Cognition?f_ri=6970","nofollow":false},{"id":6791,"name":"Aging","url":"https://www.academia.edu/Documents/in/Aging?f_ri=6970","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970"},{"id":28850,"name":"Linear models","url":"https://www.academia.edu/Documents/in/Linear_models?f_ri=6970"},{"id":49066,"name":"Epigenomics","url":"https://www.academia.edu/Documents/in/Epigenomics?f_ri=6970"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970"},{"id":73118,"name":"Walking","url":"https://www.academia.edu/Documents/in/Walking?f_ri=6970"},{"id":81559,"name":"Scotland","url":"https://www.academia.edu/Documents/in/Scotland?f_ri=6970"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=6970"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=6970"},{"id":121665,"name":"DNA methylation","url":"https://www.academia.edu/Documents/in/DNA_methylation?f_ri=6970"},{"id":268784,"name":"Physical Fitness","url":"https://www.academia.edu/Documents/in/Physical_Fitness?f_ri=6970"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=6970"},{"id":330953,"name":"Longitudinal Studies","url":"https://www.academia.edu/Documents/in/Longitudinal_Studies?f_ri=6970"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=6970"},{"id":1034181,"name":"Cross Sectional Studies","url":"https://www.academia.edu/Documents/in/Cross_Sectional_Studies?f_ri=6970"},{"id":3063336,"name":"Respiratory function tests","url":"https://www.academia.edu/Documents/in/Respiratory_function_tests?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_38681038" data-work_id="38681038" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/38681038/Obesity_induced_inflammation_a_complex_condition">Obesity induced inflammation -a complex condition</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The occurrence of overweight and obesity has risen around the world. This rate will increase in the future without appropriate interventions. Obesity is a condition with increased percentage of fat mass. Evidence based studies indicate... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_38681038" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The occurrence of overweight and obesity has risen around the world. This rate will<br />increase in the future without appropriate interventions. Obesity is a condition with increased<br />percentage of fat mass. Evidence based studies indicate that excess adiposity is accompanied<br />with a proinflammatory state. This low grade chronic inflammation could initiate and progress the metabolic disorders such as insulin resistance, type 2 diabetes, endothelial dysfunction, atherosclerosis and several types of cancers.1<br /> There are outstanding differences between<br />obesity induced inflammation and classic inflammation. Classic inflammation originates from<br />the intense immune system response to an insult, results in Basal Metabolic Rate (BMR) increase and usually diminishes over time. In contrast, obesity induced inflammation is chronic,<br />metabolic, moderate, and is associated with a reduced BMR. Some studies suggested the term<br />“metaflammation” for this inflammatory condition</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/38681038" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ad185afd312731617bef940b24782f3c" rel="nofollow" data-download="{"attachment_id":58762336,"asset_id":38681038,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/58762336/download_file?st=MTczMjQwMjc5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="79151202" href="https://independent.academia.edu/OROJ1">Obesity Research – Open Journal</a><script data-card-contents-for-user="79151202" type="text/json">{"id":79151202,"first_name":"Obesity Research","last_name":"– Open Journal","domain_name":"independent","page_name":"OROJ1","display_name":"Obesity Research – Open Journal","profile_url":"https://independent.academia.edu/OROJ1?f_ri=6970","photo":"https://0.academia-photos.com/79151202/19352780/103501756/s65_or.oj.png"}</script></span></span></li><li class="js-paper-rank-work_38681038 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="38681038"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 38681038, container: ".js-paper-rank-work_38681038", }); 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$(".js-view-count[data-work-id=38681038]").text(description); $(".js-view-count-work_38681038").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_38681038").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="38681038"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">4</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="3851" href="https://www.academia.edu/Documents/in/Obesity">Obesity</a>, <script data-card-contents-for-ri="3851" type="text/json">{"id":3851,"name":"Obesity","url":"https://www.academia.edu/Documents/in/Obesity?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="285994" href="https://www.academia.edu/Documents/in/Adipokines">Adipokines</a>, <script data-card-contents-for-ri="285994" type="text/json">{"id":285994,"name":"Adipokines","url":"https://www.academia.edu/Documents/in/Adipokines?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="458895" href="https://www.academia.edu/Documents/in/Dietary">Dietary</a><script data-card-contents-for-ri="458895" type="text/json">{"id":458895,"name":"Dietary","url":"https://www.academia.edu/Documents/in/Dietary?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=38681038]'), work: {"id":38681038,"title":"Obesity induced inflammation -a complex condition","created_at":"2019-04-01T02:26:12.043-07:00","url":"https://www.academia.edu/38681038/Obesity_induced_inflammation_a_complex_condition?f_ri=6970","dom_id":"work_38681038","summary":"The occurrence of overweight and obesity has risen around the world. This rate will\nincrease in the future without appropriate interventions. Obesity is a condition with increased\npercentage of fat mass. Evidence based studies indicate that excess adiposity is accompanied\nwith a proinflammatory state. This low grade chronic inflammation could initiate and progress the metabolic disorders such as insulin resistance, type 2 diabetes, endothelial dysfunction, atherosclerosis and several types of cancers.1\n There are outstanding differences between\nobesity induced inflammation and classic inflammation. Classic inflammation originates from\nthe intense immune system response to an insult, results in Basal Metabolic Rate (BMR) increase and usually diminishes over time. In contrast, obesity induced inflammation is chronic,\nmetabolic, moderate, and is associated with a reduced BMR. Some studies suggested the term\n“metaflammation” for this inflammatory condition","downloadable_attachments":[{"id":58762336,"asset_id":38681038,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":79151202,"first_name":"Obesity Research","last_name":"– Open Journal","domain_name":"independent","page_name":"OROJ1","display_name":"Obesity Research – Open Journal","profile_url":"https://independent.academia.edu/OROJ1?f_ri=6970","photo":"https://0.academia-photos.com/79151202/19352780/103501756/s65_or.oj.png"}],"research_interests":[{"id":3851,"name":"Obesity","url":"https://www.academia.edu/Documents/in/Obesity?f_ri=6970","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":285994,"name":"Adipokines","url":"https://www.academia.edu/Documents/in/Adipokines?f_ri=6970","nofollow":false},{"id":458895,"name":"Dietary","url":"https://www.academia.edu/Documents/in/Dietary?f_ri=6970","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_5045345" data-work_id="5045345" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/5045345/Evidence_for_enhanced_Mediterranean_thermohaline_circulation_during_rapid_climatic_coolings">Evidence for enhanced Mediterranean thermohaline circulation during rapid climatic coolings</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/5045345" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="8a95d3fce09087de64e8e5631cfbfdc3" rel="nofollow" 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window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_5045345"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_5045345 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="5045345"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 5045345; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=5045345]").text(description); $(".js-view-count-work_5045345").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_5045345").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="5045345"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="400" href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a>, <script data-card-contents-for-ri="400" type="text/json">{"id":400,"name":"Earth Sciences","url":"https://www.academia.edu/Documents/in/Earth_Sciences?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4753" href="https://www.academia.edu/Documents/in/Climate_variability">Climate variability</a>, <script data-card-contents-for-ri="4753" type="text/json">{"id":4753,"name":"Climate variability","url":"https://www.academia.edu/Documents/in/Climate_variability?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="31945" href="https://www.academia.edu/Documents/in/Sea_surface_temperature">Sea surface temperature</a><script data-card-contents-for-ri="31945" type="text/json">{"id":31945,"name":"Sea surface temperature","url":"https://www.academia.edu/Documents/in/Sea_surface_temperature?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=5045345]'), work: {"id":5045345,"title":"Evidence for enhanced Mediterranean thermohaline circulation during rapid climatic coolings","created_at":"2013-11-09T18:29:45.346-08:00","url":"https://www.academia.edu/5045345/Evidence_for_enhanced_Mediterranean_thermohaline_circulation_during_rapid_climatic_coolings?f_ri=6970","dom_id":"work_5045345","summary":null,"downloadable_attachments":[{"id":49472677,"asset_id":5045345,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":6723560,"first_name":"Miquel","last_name":"Canals","domain_name":"ub","page_name":"MiquelCanals","display_name":"Miquel Canals","profile_url":"https://ub.academia.edu/MiquelCanals?f_ri=6970","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":400,"name":"Earth Sciences","url":"https://www.academia.edu/Documents/in/Earth_Sciences?f_ri=6970","nofollow":false},{"id":4753,"name":"Climate variability","url":"https://www.academia.edu/Documents/in/Climate_variability?f_ri=6970","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":31945,"name":"Sea surface temperature","url":"https://www.academia.edu/Documents/in/Sea_surface_temperature?f_ri=6970","nofollow":false},{"id":50243,"name":"Mediterranean Sea","url":"https://www.academia.edu/Documents/in/Mediterranean_Sea?f_ri=6970"},{"id":118582,"name":"Physical sciences","url":"https://www.academia.edu/Documents/in/Physical_sciences?f_ri=6970"},{"id":138390,"name":"Thermohaline Circulation","url":"https://www.academia.edu/Documents/in/Thermohaline_Circulation?f_ri=6970"},{"id":174781,"name":"Oscillations","url":"https://www.academia.edu/Documents/in/Oscillations?f_ri=6970"},{"id":241723,"name":"Earth and Planetary Science","url":"https://www.academia.edu/Documents/in/Earth_and_Planetary_Science?f_ri=6970"},{"id":322541,"name":"Deep water","url":"https://www.academia.edu/Documents/in/Deep_water?f_ri=6970"},{"id":970387,"name":"Organic Matter","url":"https://www.academia.edu/Documents/in/Organic_Matter?f_ri=6970"},{"id":1272997,"name":"Western Mediterranean","url":"https://www.academia.edu/Documents/in/Western_Mediterranean?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27799840" data-work_id="27799840" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27799840/Correlation_of_TSLP_IL_33_and_CD4_CD25_FOXP3_T_regulatory_Treg_in_pediatric_asthma">Correlation of TSLP, IL-33, and CD4 + CD25 + FOXP3 + T regulatory (Treg) in pediatric asthma</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Newly discovered cytokines TSLP and IL33 are being studied as important indicators of Th2 inflammation and their effect on Treg cells is likely to modulate immune response. We attempted to study TSLP and IL-33 and then correlated with... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_27799840" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Newly discovered cytokines TSLP and IL33 are being studied as important indicators of Th2 inflammation and their effect on Treg cells is likely to modulate immune response. We attempted to study TSLP and IL-33 and then correlated with Tregs in order to find possible biomarker in these patients. Sixty-five children (37 with asthma only and 28 with asthma and rhinitis) aged 6.4 ± 3.2 years (patient group) and 15 healthy children aged 8.0 ± 2.6 years (control group) were recruited in this study. In vitro analysis of TSLP and IL-33 was done in serum samples of 65 newly diagnosed children for allergic asthma and 15 healthy children using the sandwich ELISA method. The expression of Treg cells (CD4 + CD25 + FOXP3+) was analyzed by flow cytometry. The mean TSLP in the patient group (592 ± 68 pg/ml) was significantly higher than controls (215 ± 45 pg/ml) (p &lt; 0.05). Alternatively, the expression of FOXP3 + T reg cells was significantly lower in the patient group (52 ± 36) compared with t...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/27799840" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5125b5cc260680c275862b74d5d10910" rel="nofollow" data-download="{"attachment_id":48080694,"asset_id":27799840,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48080694/download_file?st=MTczMjQwMjc5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="52047550" href="https://independent.academia.edu/AnilChauhan31">Anil Chauhan</a><script data-card-contents-for-user="52047550" type="text/json">{"id":52047550,"first_name":"Anil","last_name":"Chauhan","domain_name":"independent","page_name":"AnilChauhan31","display_name":"Anil Chauhan","profile_url":"https://independent.academia.edu/AnilChauhan31?f_ri=6970","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_27799840 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="27799840"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 27799840, container: ".js-paper-rank-work_27799840", }); 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$(".js-view-count[data-work-id=27799840]").text(description); $(".js-view-count-work_27799840").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_27799840").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="27799840"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6599" href="https://www.academia.edu/Documents/in/Flow_Cytometry">Flow Cytometry</a>, <script data-card-contents-for-ri="6599" type="text/json">{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9111" href="https://www.academia.edu/Documents/in/Cytokines">Cytokines</a>, <script data-card-contents-for-ri="9111" type="text/json">{"id":9111,"name":"Cytokines","url":"https://www.academia.edu/Documents/in/Cytokines?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9968" href="https://www.academia.edu/Documents/in/Asthma">Asthma</a><script data-card-contents-for-ri="9968" type="text/json">{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=27799840]'), work: {"id":27799840,"title":"Correlation of TSLP, IL-33, and CD4 + CD25 + FOXP3 + T regulatory (Treg) in pediatric asthma","created_at":"2016-08-15T19:21:01.061-07:00","url":"https://www.academia.edu/27799840/Correlation_of_TSLP_IL_33_and_CD4_CD25_FOXP3_T_regulatory_Treg_in_pediatric_asthma?f_ri=6970","dom_id":"work_27799840","summary":"Newly discovered cytokines TSLP and IL33 are being studied as important indicators of Th2 inflammation and their effect on Treg cells is likely to modulate immune response. We attempted to study TSLP and IL-33 and then correlated with Tregs in order to find possible biomarker in these patients. Sixty-five children (37 with asthma only and 28 with asthma and rhinitis) aged 6.4 ± 3.2 years (patient group) and 15 healthy children aged 8.0 ± 2.6 years (control group) were recruited in this study. In vitro analysis of TSLP and IL-33 was done in serum samples of 65 newly diagnosed children for allergic asthma and 15 healthy children using the sandwich ELISA method. The expression of Treg cells (CD4 + CD25 + FOXP3+) was analyzed by flow cytometry. The mean TSLP in the patient group (592 ± 68 pg/ml) was significantly higher than controls (215 ± 45 pg/ml) (p \u0026lt; 0.05). Alternatively, the expression of FOXP3 + T reg cells was significantly lower in the patient group (52 ± 36) compared with t...","downloadable_attachments":[{"id":48080694,"asset_id":27799840,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":52047550,"first_name":"Anil","last_name":"Chauhan","domain_name":"independent","page_name":"AnilChauhan31","display_name":"Anil Chauhan","profile_url":"https://independent.academia.edu/AnilChauhan31?f_ri=6970","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry?f_ri=6970","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":9111,"name":"Cytokines","url":"https://www.academia.edu/Documents/in/Cytokines?f_ri=6970","nofollow":false},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=6970","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=6970"},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=6970"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=6970"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=6970"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=6970"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=6970"},{"id":1272906,"name":"Enzyme Linked Immunosorbent Assay","url":"https://www.academia.edu/Documents/in/Enzyme_Linked_Immunosorbent_Assay?f_ri=6970"},{"id":1799441,"name":"Rhinitis","url":"https://www.academia.edu/Documents/in/Rhinitis?f_ri=6970"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin?f_ri=6970"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=6970"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27469128 coauthored" data-work_id="27469128" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27469128/Artificial_Neural_Networks_in_the_Discrimination_of_Alzheimers_disease_Using_Biomarkers_Data">Artificial Neural Networks in the Discrimination of Alzheimer's disease Using Biomarkers Data</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">— This paper presents the results of a study developing artificial neural network system (ANN) for classification of Alzheimer's disease (AD) and healthy patients. The classification is done using biomarkers, from cerebrospinal fluid:... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_27469128" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">— This paper presents the results of a study developing artificial neural network system (ANN) for classification of Alzheimer's disease (AD) and healthy patients. The classification is done using biomarkers, from cerebrospinal fluid: albumin ratio (CSF/Serum and/or Plasma), Aβ40 (CSF), Aβ42 (CSF), tau-total (CSF) and tau-phospho (CSF). Neural network input parameters are datasets from Alzbiomarkers database. Independent t-test is used to calculate statistical difference between input parameters. Developed neural network was validated with 80 subjects from Alzbiomarkers database. Out of 45 AD subjects, 43 were correctly classified as AD patients, obtaining a sensitivity of 95.5%, and out of 35 healthy subjects 32 were correctly classified obtaining specificity of 91.43%.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/27469128" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b8ded8821d4caa2069721e07d20f2085" rel="nofollow" data-download="{"attachment_id":47726927,"asset_id":27469128,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47726927/download_file?st=MTczMjQwMjc5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38881998" href="https://ibu-ba.academia.edu/AlmirBadnjevic">Almir Badnjevic</a><script data-card-contents-for-user="38881998" type="text/json">{"id":38881998,"first_name":"Almir","last_name":"Badnjevic","domain_name":"ibu-ba","page_name":"AlmirBadnjevic","display_name":"Almir Badnjevic","profile_url":"https://ibu-ba.academia.edu/AlmirBadnjevic?f_ri=6970","photo":"https://0.academia-photos.com/38881998/10766762/17329912/s65_almir.badnjevic.jpg"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-27469128">+1</span><div class="hidden js-additional-users-27469128"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://ibu-ba.academia.edu/LejlaGurbeta">Lejla Gurbeta Pokvić</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-27469128'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-27469128').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_27469128 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="27469128"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 27469128, container: ".js-paper-rank-work_27469128", }); });</script></li><li class="js-percentile-work_27469128 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27469128; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_27469128"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_27469128 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="27469128"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27469128; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27469128]").text(description); $(".js-view-count-work_27469128").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_27469128").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="27469128"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">3</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="3776" href="https://www.academia.edu/Documents/in/Alzheimers_Disease">Alzheimer's Disease</a>, <script data-card-contents-for-ri="3776" type="text/json">{"id":3776,"name":"Alzheimer's Disease","url":"https://www.academia.edu/Documents/in/Alzheimers_Disease?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="54123" href="https://www.academia.edu/Documents/in/Artificial_Neural_Networks">Artificial Neural Networks</a><script data-card-contents-for-ri="54123" type="text/json">{"id":54123,"name":"Artificial Neural Networks","url":"https://www.academia.edu/Documents/in/Artificial_Neural_Networks?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=27469128]'), work: {"id":27469128,"title":"Artificial Neural Networks in the Discrimination of Alzheimer's disease Using Biomarkers Data","created_at":"2016-08-02T07:47:38.382-07:00","url":"https://www.academia.edu/27469128/Artificial_Neural_Networks_in_the_Discrimination_of_Alzheimers_disease_Using_Biomarkers_Data?f_ri=6970","dom_id":"work_27469128","summary":"— This paper presents the results of a study developing artificial neural network system (ANN) for classification of Alzheimer's disease (AD) and healthy patients. The classification is done using biomarkers, from cerebrospinal fluid: albumin ratio (CSF/Serum and/or Plasma), Aβ40 (CSF), Aβ42 (CSF), tau-total (CSF) and tau-phospho (CSF). Neural network input parameters are datasets from Alzbiomarkers database. Independent t-test is used to calculate statistical difference between input parameters. Developed neural network was validated with 80 subjects from Alzbiomarkers database. Out of 45 AD subjects, 43 were correctly classified as AD patients, obtaining a sensitivity of 95.5%, and out of 35 healthy subjects 32 were correctly classified obtaining specificity of 91.43%.","downloadable_attachments":[{"id":47726927,"asset_id":27469128,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38881998,"first_name":"Almir","last_name":"Badnjevic","domain_name":"ibu-ba","page_name":"AlmirBadnjevic","display_name":"Almir Badnjevic","profile_url":"https://ibu-ba.academia.edu/AlmirBadnjevic?f_ri=6970","photo":"https://0.academia-photos.com/38881998/10766762/17329912/s65_almir.badnjevic.jpg"},{"id":40539149,"first_name":"Lejla","last_name":"Gurbeta Pokvić","domain_name":"ibu-ba","page_name":"LejlaGurbeta","display_name":"Lejla Gurbeta Pokvić","profile_url":"https://ibu-ba.academia.edu/LejlaGurbeta?f_ri=6970","photo":"https://0.academia-photos.com/40539149/13713686/19610344/s65_lejla.gurbeta.png"}],"research_interests":[{"id":3776,"name":"Alzheimer's Disease","url":"https://www.academia.edu/Documents/in/Alzheimers_Disease?f_ri=6970","nofollow":false},{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false},{"id":54123,"name":"Artificial Neural Networks","url":"https://www.academia.edu/Documents/in/Artificial_Neural_Networks?f_ri=6970","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_25930184" data-work_id="25930184" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/25930184/Menstrual_Suppression_Iron_Homeostasis_and_Disease_Risk">Menstrual Suppression, Iron Homeostasis, and Disease Risk</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/25930184" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="46f7e245f20f4fc761ef01bcf4d209b5" rel="nofollow" data-download="{"attachment_id":46287495,"asset_id":25930184,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46287495/download_file?st=MTczMjQwMjc5Myw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="49650412" href="https://independent.academia.edu/RalphDepalma">Ralph Depalma</a><script data-card-contents-for-user="49650412" type="text/json">{"id":49650412,"first_name":"Ralph","last_name":"Depalma","domain_name":"independent","page_name":"RalphDepalma","display_name":"Ralph Depalma","profile_url":"https://independent.academia.edu/RalphDepalma?f_ri=6970","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_25930184 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="25930184"><i class="u-m1x fa 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href="https://www.academia.edu/Documents/in/Nursing">Nursing</a>, <script data-card-contents-for-ri="588" type="text/json">{"id":588,"name":"Nursing","url":"https://www.academia.edu/Documents/in/Nursing?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6970" href="https://www.academia.edu/Documents/in/Biomarkers">Biomarkers</a>, <script data-card-contents-for-ri="6970" type="text/json">{"id":6970,"name":"Biomarkers","url":"https://www.academia.edu/Documents/in/Biomarkers?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="55646" href="https://www.academia.edu/Documents/in/Postmenopausal_Women">Postmenopausal Women</a>, <script data-card-contents-for-ri="55646" type="text/json">{"id":55646,"name":"Postmenopausal Women","url":"https://www.academia.edu/Documents/in/Postmenopausal_Women?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="158597" href="https://www.academia.edu/Documents/in/Iron">Iron</a><script data-card-contents-for-ri="158597" type="text/json">{"id":158597,"name":"Iron","url":"https://www.academia.edu/Documents/in/Iron?f_ri=6970","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=25930184]'), work: {"id":25930184,"title":"Menstrual Suppression, Iron Homeostasis, and Disease Risk","created_at":"2016-06-06T11:57:46.042-07:00","url":"https://www.academia.edu/25930184/Menstrual_Suppression_Iron_Homeostasis_and_Disease_Risk?f_ri=6970","dom_id":"work_25930184","summary":null,"downloadable_attachments":[{"id":46287495,"asset_id":25930184,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":49650412,"first_name":"Ralph","last_name":"Depalma","domain_name":"independent","page_name":"RalphDepalma","display_name":"Ralph 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href="https://www.academia.edu/Documents/in/Chemical_Engineering">Chemical Engineering</a>, <script data-card-contents-for-ri="72" type="text/json">{"id":72,"name":"Chemical Engineering","url":"https://www.academia.edu/Documents/in/Chemical_Engineering?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="524" href="https://www.academia.edu/Documents/in/Analytical_Chemistry">Analytical Chemistry</a>, <script data-card-contents-for-ri="524" type="text/json">{"id":524,"name":"Analytical Chemistry","url":"https://www.academia.edu/Documents/in/Analytical_Chemistry?f_ri=6970","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="5769" href="https://www.academia.edu/Documents/in/Mass_Spectrometry">Mass Spectrometry</a>, <script data-card-contents-for-ri="5769" type="text/json">{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry?f_ri=6970","nofollow":false}</script><a 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With Moderate to Severe Benign Prostatic Hyperplasia: 4-Year Data From the CombAT Trial</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/28228361" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2d5eccb0446e1f98d8adb6769faf2606" rel="nofollow" data-download="{"attachment_id":48544260,"asset_id":28228361,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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