Gene Ontology Resource

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background-image: linear-gradient(to right, rgba(0, 23, 79, 1), rgba(0, 23, 79, 0.8), rgba(0, 23, 79, 0.5)), url(./assets/gene.jpeg); background-blend-mode: initial; background-size: cover; background-position: top; margin-top: -70px !important; box-shadow: rgba(0, 0, 0, 0.15) 0px 1rem 4rem; ">  <div class="container" style="width: 98%;"> <div class="container" style="width: 98%; padding-top: 50px;"> <p style="color: #f2be54; font-size: 13px; text-align: right; letter-spacing: 0.35rem; padding: 0px; padding-right: 1em; margin-bottom: 10px; /* transform: translateY(-25px); */ transform: translate(50px, -25px); /* background-color: white; */ /* text-shadow: 1px 1px black;*/"> Current release <span id="id_release_date" class="header_stat"></span>: <span id="id_terms" class="header_stat"></span> GO terms | <span id="id_annotations" class="header_stat"></span> annotations<br> <span id="id_geneproducts" class="header_stat"></span> gene products | <span id="id_species" class="header_stat"></span> species <span style="text-align: right; margin-left: 5px;"> (<a href="/stats.html" style="color: cyan;">see statistics</a>) </span> </p> <h1 class="site__title" style=" font-size: 45px; letter-spacing: 0.35rem; text-transform: uppercase; font-weight: 400;">The Gene Ontology Resource</h1> <div class="row"> <div class="col-md-8"> <p class="site__statement" style="font-size: 16px; max-width: 820px; margin-bottom: 0px; text-align: justify;"> The mission of the GO Consortium is to develop a comprehensive, <b>computational model of biological systems</b>, ranging from the molecular to the organism level, across the multiplicity of species in the tree of life. <br> <br> The Gene Ontology (GO) knowledgebase is the world’s largest source of information on the functions of genes. This knowledge is both human-readable and machine-readable, and is a foundation for computational analysis of large-scale molecular biology and genetics experiments in biomedical research. </p> <br> <p> <form action="https://amigo.geneontology.org/amigo/medial_search" class="" method="GET" name="form-search" target="_blank" style="max-width: 810px;"> <div class="center-block" style="padding-bottom: 1em;"> <div class="input-group"> <input id="gsf-query" class="form-control input-lg go-search-bar" style="width: 100%; border-radius:25px 0px 0px 25px;height: 50px; font-size: 16px;" name="q" placeholder="Search GO term or Gene Product in AmiGO ..." title="Hint: add a space after completing a word to narrow the search." type="text"> <span class="input-group-btn"> <button class="btn btn-primary u-no-transform go-search-bar u-anim-zoom-in" type="submit" style="padding-left: 15px; padding-right: 15px; border-radius:0px 25px 25px 0px; height: 50px; background-color: #22612C; border-color: #22612C;" title="Search for GO terms or Gene Products"> <i class="fa-solid fa-search"></i> </button> </span> </div> <div style="color:white; margin-top: 5px; margin-left:10px; font-size: 16px"> <input type="radio" name="searchtype" value="all" checked="checked"> Any   <input type="radio" name="searchtype" value="ontology"> Ontology   <input type="radio" name="searchtype" value="geneproduct"> Gene Product </div> </div> </form> </p> </div> <div class="col-md-4" style="transform: translateY(-15px);"> <h3 style="display: block; margin-left: auto; margin-right: auto; font-size: 24px; letter-spacing: 0.18rem; margin-top: 0px; margin-bottom: 0px; "> <a href="/docs/go-enrichment-analysis/" style="color:white; font-size: 22px;">GO Enrichment Analysis <i class="fa-solid fa-question-circle"></i> </a> </h3> <i style=" width: 100%; display: block; font-size: 14px;">Powered by <a href="https://pantherdb.org" style="color: white" target="blank">PANTHER</a></i> <form action="https://pantherdb.org/webservices/go/overrep.jsp" class="form-inline" role="form" method="POST" target="_blank"> <input name="correction" value="fdr" type="hidden"> <input name="format" value="html" type="hidden"> <input name="resource" value="PANTHER" type="hidden"> <textarea id="landing_gene_input" class="form-control" rows="6" name="input" placeholder="Your gene IDs here..." style="width:100%; resize: none; margin-bottom: 5px; font-size: 14px;"></textarea> <div class="form-group" style="width:100%;margin-bottom: 5px;"> <select id="rte_ontology" class="form-control" name="ontology" style="width:100%"> <option value="biological_process">biological process</option> <option value="molecular_function">molecular function</option> <option value="cellular_component">cellular component</option> </select> </div> <div class="input-group"> <div class="form-group"> <select id="rte_species" class="form-control" name="species" style="width: 100%;"> <option value="HUMAN">Homo sapiens</option> <option value="MOUSE">Mus musculus</option> <option value="RAT">Rattus norvegicus</option> <option value="CHICK">Gallus gallus</option> <option value="DANRE">Danio rerio</option> <option value="DROME">Drosophila melanogaster</option> <option value="CAEEL">Caenorhabditis elegans</option> <option value="YEAST">Saccharomyces cerevisiae</option> <option value="SCHPO">Schizosaccharomyces pombe</option> <option value="DICDI">Dictyostelium discoideum</option> <option value="ARATH">Arabidopsis thaliana</option> <option value="ECOLI">Escherichia coli</option> <option value="EMENI">Emericella nidulans</option> <option value="AMBTC">Amborella trichopoda</option> <option value="ANOCA">Anolis carolinensis</option> <option value="ANOGA">Anopheles gambiae</option> <option value="AQUAE">Aquifex aeolicus</option> <option value="ASHGO">Ashbya gossypii</option> <option value="BACCR">Bacillus cereus</option> <option value="BACSU">Bacillus subtilis</option> <option value="BACTN">Bacteroides thetaiotaomicron</option> <option value="BATDJ">Batrachochytrium dendrobatidis</option> <option value="BOVIN">Bos taurus</option> <option value="BRADI">Brachypodium distachyon</option> <option value="BRADU">Bradyrhizobium diazoefficiens</option> <option value="BRAFL">Branchiostoma floridae</option> <option value="BRARP">Brassica rapa subsp. pekinensis</option> <option value="CAEBR">Caenorhabditis briggsae</option> <option value="CANAL">Candida albicans</option> <option value="CANLF">Canis lupus familiaris</option> <option value="CHLTR">Chlamydia trachomatis</option> <option value="CHLRE">Chlamydomonas reinhardtii</option> <option value="CHLAA">Chloroflexus aurantiacus</option> <option value="CIOIN">Ciona intestinalis</option> <option value="CITSI">Citrus sinensis</option> <option value="CLOBH">Clostridium botulinum</option> <option value="COXBU">Coxiella burnetii</option> <option value="CRYNJ">Cryptococcus neoformans</option> <option value="CUCSA">Cucumis sativus</option> <option value="DAPPU">Daphnia pulex</option> <option value="DEIRA">Deinococcus radiodurans</option> <option value="DICTD">Dictyoglomus turgidum</option> <option value="DICPU">Dictyostelium purpureum</option> <option value="ENTHI">Entamoeba histolytica</option> <option value="HORSE">Equus caballus</option> <option value="ERYGU">Erythranthe guttata</option> <option value="FELCA">Felis catus</option> <option value="FUSNN">Fusobacterium nucleatum</option> <option value="GEOSL">Geobacter sulfurreducens</option> <option value="GIAIC">Giardia intestinalis</option> <option value="GLOVI">Gloeobacter violaceus</option> <option value="SOYBN">Glycine max</option> <option value="GORGO">Gorilla gorilla gorilla</option> <option value="GOSHI">Gossypium hirsutum</option> <option value="HAEIN">Haemophilus influenzae</option> <option value="HALSA">Halobacterium salinarum</option> <option value="HELAN">Helianthus annuus</option> <option value="HELPY">Helicobacter pylori</option> <option value="HORVV">Hordeum vulgare subsp. vulgare</option> <option value="IXOSC">Ixodes scapularis</option> <option value="KORCO">Korarchaeum cryptofilum</option> <option value="LEIMA">Leishmania major</option> <option value="LEPIN">Leptospira interrogans</option> <option value="LISMO">Listeria monocytogenes</option> <option value="MACMU">Macaca mulatta</option> <option value="MEDTR">Medicago truncatula</option> <option value="METJA">Methanocaldococcus jannaschii</option> <option value="METAC">Methanosarcina acetivorans</option> <option value="MONDO">Monodelphis domestica</option> <option value="MONBE">Monosiga brevicollis</option> <option value="MUSAM">Musa acuminata subsp. malaccensis</option> <option value="MYCTU">Mycobacterium tuberculosis</option> <option value="NEIMB">Neisseria meningitidis serogroup b</option> <option value="NEMVE">Nematostella vectensis</option> <option value="ASPFU">Neosartorya fumigata</option> <option value="NEUCR">Neurospora crassa</option> <option value="TOBAC">Nicotiana tabacum</option> <option value="NITMS">Nitrosopumilus maritimus</option> <option value="ORNAN">Ornithorhynchus anatinus</option> <option value="ORYSJ">Oryza sativa</option> <option value="ORYLA">Oryzias latipes</option> <option value="OSTTA">Ostreococcus tauri</option> <option value="PANTR">Pan troglodytes</option> <option value="PARTE">Paramecium tetraurelia</option> <option value="PHANO">Phaeosphaeria nodorum</option> <option value="PHODC">Phoenix dactylifera</option> <option value="PHYPA">Physcomitrella patens</option> <option value="PHYRM">Phytophthora ramorum</option> <option value="PLAF7">Plasmodium falciparum</option> <option value="POPTR">Populus trichocarpa</option> <option value="PRIPA">Pristionchus pacificus</option> <option value="PRUPE">Prunus persica</option> <option value="PSEAE">Pseudomonas aeruginosa</option> <option value="PUCGT">Puccinia graminis</option> <option value="PYRAE">Pyrobaculum aerophilum</option> <option value="RHOBA">Rhodopirellula baltica</option> <option value="RICCO">Ricinus communis</option> <option value="SALTY">Salmonella typhimurium</option> <option value="SCLS1">Sclerotinia sclerotiorum</option> <option value="SETIT">Setaria italica</option> <option value="SHEON">Shewanella oneidensis</option> <option value="SOLLC">Solanum lycopersicum</option> <option value="SORBI">Sorghum bicolor</option> <option value="STAA8">Staphylococcus aureus</option> <option value="STRR6">Streptococcus pneumoniae</option> <option value="STRCO">Streptomyces coelicolor</option> <option value="STRPU">Strongylocentrotus purpuratus</option> <option value="SULSO">Sulfolobus solfataricus</option> <option value="PIG">Sus scrofa</option> <option value="SYNY3">Synechocystis</option> <option value="THAPS">Thalassiosira pseudonana</option> <option value="THECC">Theobroma cacao</option> <option value="THEKO">Thermococcus kodakaraensis</option> <option value="THEYD">Thermodesulfovibrio yellowstonii</option> <option value="THEMA">Thermotoga maritima</option> <option value="TRICA">Tribolium castaneum</option> <option value="TRIVA">Trichomonas vaginalis</option> <option value="TRIAD">Trichoplax adhaerens</option> <option value="WHEAT">Triticum aestivum</option> <option value="TRYB2">Trypanosoma brucei</option> <option value="USTMA">Ustilago maydis</option> <option value="VIBCH">Vibrio cholerae</option> <option value="VITVI">Vitis vinifera</option> <option value="XANCP">Xanthomonas campestris</option> <option value="XENTR">Xenopus tropicalis</option> <option value="YARLI">Yarrowia lipolytica</option> <option value="YERPE">Yersinia pestis</option> <option value="MAIZE">Zea mays</option> <option value="HELRO">helobdella robusta</option> <option value="LEPOC">lepisosteus oculatus</option> <option value="MYCGE">mycoplasma genitalium</option> </select> </div> <span class="input-group-btn"> <button type="button" class="btn btn-primary u-no-transform u-anim-zoom-in" style="background-color: #22612C; border-color: #22612C; margin-left: 4px;" onclick="setExample()" title="Cycle through different Gene Set examples"> Examples </button> <button type="submit" class="btn btn-primary u-no-transform u-anim-move-right" style="background-color: #22612C; border-color: #22612C; margin-left: 4px;" title="Launch GO Enrichment Analysis"> Launch <i class="fa-solid fa-chevron-right u-line-height-single"></i> </button> </span> </div> <div id="input_hint" class="input_hint">Hint: can use UniProt ID/AC, Gene Name, Gene Symbols, MOD IDs</div> </form> </div>  <div style=" border-radius: 35px 10px 35px 10px; padding: 20px; padding-top: 1px; margin-top: 20px; font-size: 16px; color: black; ">  </div> </div> </div> </div> <hr style="margin:0px; padding:0px"> </div> <div class="container" style="margin-right: auto; margin-left: auto; padding-left: 0px; padding-right: 0px; width: 98%; max-width: 1500px;"> <div class="row"> <div class="card col-md-3"> <div class="card__container" style="background-color: rgba(135, 174, 180, 0.3);"> <div onclick="location.href = '/docs/ontology-documentation/'" class="card__picture card__picture__dna--red"> <h4 class="card__heading"><i class="fa-solid fa-share-nodes"></i> Ontology</h4> </div> <p class="card__description"> The network of biological classes describing the current best representation of the “universe” of biology: the molecular functions, cellular locations, and processes gene products may carry out. </p> <div class="card__bottom"> <div> <a href="/docs/ontology-documentation/" class="card__link"> <i class="fa-solid fa-info"></i>   GO Ontology Overview</a> </div> <div> <a href="https://amigo.geneontology.org/amigo/dd_browse" class="card__link" target="blank"> <i class="fa-regular fa-clone"></i>   Browse in AmiGO</a> </div> <div> <a href="/docs/download-ontology/" class="card__link"> <i class="fa-solid fa-download"></i>   Download</a> </div> </div> </div> </div> <div class="card col-md-3"> <div class="card__container" style="background-color: rgba(135, 174, 180, 0.3);"> <div onclick="location.href = '/docs/go-annotations/'" class="card__picture card__picture__standard-annotation"> <h4 class="card__heading"><i class="fa-solid fa-edit"></i> Annotation</h4> </div> <p class="card__description"> Statements, based on specific, traceable scientific evidence, asserting that a specific gene product is a real exemplar of a particular GO class. </p> <div class="card__bottom"> <div> <a href="/docs/go-annotations/" class="card__link"> <i class="fa-solid fa-info"></i>   GO Annotations Overview</a> </div> <div> <a href="https://amigo.geneontology.org/amigo/search/annotation" class="card__link" target="blank"> <i class="fa-regular fa-clone"></i>   Browse in AmiGO</a> </div> <div> <a href="/docs/download-go-annotations/" class="card__link" target="blank"> <i class="fa-solid fa-download"></i>   Download</a> </div> </div> </div> </div> <div class="card col-md-3"> <div class="card__container" style="background-color: rgba(135, 174, 180, 0.3);"> <div onclick="location.href = '/docs/gocam-overview/'" class="card__picture card__picture__gocam"> <h4 class="card__heading"><i class="fa-solid fa-cog"></i> GO-CAM</h4> </div> <p class="card__description"> GO Causal Activity Model (GO-CAM) provides a structured framework to link standard GO annotations into a more complete model of a biological system. </p> <div class="card__bottom"> <div> <a href="/docs/gocam-overview/" class="card__link"> <i class="fa-solid fa-info"></i>   GO-CAM Overview</a> </div> <div> <a href="http://geneontology.org/go-cam" class="card__link"> <i class="fa-regular fa-clone"></i>   Browse GO-CAMs</a> </div> <div> <a href="/docs/download-go-cams/" class="card__link"> <i class="fa-solid fa-download"></i>   Download</a> </div> </div> </div> </div> <div class="card col-md-3"> <div class="card__container" style="background-color: rgba(135, 174, 180, 0.3);"> <div onclick="location.href = '/docs/tools-overview/'" class="card__picture card__picture__dna--green"> <h4 class="card__heading"><i class="fa-solid fa-cog"></i> Tools & Guides</h4> </div> <p class="card__description"> Tools to curate, browse, search, visualize and download both the ontology and annotations. 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