Biology of Cancer - Cancer Currents Blog

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Topics include cancer metastasis, the tumor microenvironment, and new targets for cancer therapies.</p> </div> </div> <div class="slot-item last-SI"> <div class="dynamic list has-images"> <ul> <div class="views-element-container"><div class="js-view-dom-id-753302376def4f8c655327efc79b0da3289f1f68ba42e6e238071af5a6ec688f"> <div class="item-list"> <ul> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2024/breast-cancer-sensory-nerves-metastasis-genes"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2024-09/Breast%20cancer%20sensory%20neurons-v1-high%20res.png?h=ffccce4d&itok=45h39-jH" width="228" height="171" alt="An illustration of a tumor recruiting a nearby nerve and how that action helps cancer cells leave the tumor." /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2024/breast-cancer-sensory-nerves-metastasis-genes" onclick=""> <span>Breast Cancer May Spread by Recruiting Nearby Sensory Nerves</span> </a> <div class="description"> <div class="date-author"> <time datetime="2024-09-20T12:00:00Z">September 20, 2024</time>, by Sharon Reynolds </div> <p>A new study may provide important new insights into breast cancer metastasis. Blood vessels within tumors release a molecule that draws sensory nerves closer to the tumors, the study shows. This close proximity turns on genes in the cancer cells that drive metastasis.</p> <p><a href="/news-events/cancer-currents-blog/2024/breast-cancer-sensory-nerves-metastasis-genes">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2024/new-cancer-drug-targets-from-proteogenomics-data"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2024-09/CPTAC%20conceptual%203_0.JPG?h=cad18b7d&itok=I-rg0Har" width="228" height="171" alt="A conceptual cartoon meant to represent the translation of proteogenomic data to drug targets." /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2024/new-cancer-drug-targets-from-proteogenomics-data" onclick=""> <span>Study Identifies Hundreds of Potential Targets for Cancer Drugs </span> </a> <div class="description"> <div class="date-author"> <time datetime="2024-09-11T12:00:00Z">September 11, 2024</time>, by Linda Wang </div> <p>Researchers have identified hundreds of promising targets for existing drugs or potential new cancer drugs. The findings relied heavily on proteogenomic data from more than 1,000 tumors representing 10 types of cancer released last year by NCI's CPTAC program.</p> <p><a href="/news-events/cancer-currents-blog/2024/new-cancer-drug-targets-from-proteogenomics-data">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2024/ancient-retrovirus-dna-ltr10-cancer"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2024-09/retrovirus.PNG?h=2470f232&itok=TN8JkYB4" width="228" height="171" alt="Illustration of a retrovirus infecting a host cell. Its viral RNA converts into DNA and becomes part of the host cell's DNA. The cell produces more retroviruses that can go on to infect other cells." /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2024/ancient-retrovirus-dna-ltr10-cancer" onclick=""> <span>DNA from Ancient Viruses Helps Many Cancers Grow</span> </a> <div class="description"> <div class="date-author"> <time datetime="2024-09-06T12:00:00Z">September 6, 2024</time>, by Nadia Jaber </div> <p>DNA fragments from retroviruses that are millions of years old appear to be active in a variety of cancers, a new study found. One virus-derived DNA fragment in particular, known as LTR10, turns on cancer-related genes in multiple types of cancer.</p> <p><a href="/news-events/cancer-currents-blog/2024/ancient-retrovirus-dna-ltr10-cancer">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2024/cancer-treatment-resistance-engineering-evolution"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2024-08/conceptual%20genetic%20engineering.jpg?h=e0dc2787&itok=QBHNI0S8" width="228" height="171" alt="A conceptual image with a small segment of a DNA double helix being removed with tweezers." /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2024/cancer-treatment-resistance-engineering-evolution" onclick=""> <span>To Combat Cancer Treatment Resistance, Researchers Try Leveraging Evolution</span> </a> <div class="description"> <div class="date-author"> <time datetime="2024-08-22T12:00:00Z">August 22, 2024</time>, by Carmen Phillips </div> <p>Scientists have developed a strategy for treating cancer that takes advantage of tumors’ ability to rapidly evolve and turns it against them. It involves intentionally making some tumor cells resistant to a specific treatment from the get-go.</p> <p><a href="/news-events/cancer-currents-blog/2024/cancer-treatment-resistance-engineering-evolution">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2024/pancreatic-cancer-kras-inhibitors-chemotherapy"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2024-08/Chemobag-iStock.jpg?h=0d3b95cb&itok=uk131qqc" width="228" height="171" alt="A chemotherapy bag hanging and a woman receiving treatment sitting in a chair." /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2024/pancreatic-cancer-kras-inhibitors-chemotherapy" onclick=""> <span>Can Chemo Help KRAS Inhibitors Work Better Against Pancreatic Cancer?</span> </a> <div class="description"> <div class="date-author"> <time datetime="2024-08-20T12:00:00Z">August 20, 2024</time>, by Sharon Reynolds </div> <p>Two new studies in mice show that adding chemotherapy to the experimental KRAS inhibitor MRTX1133 greatly reduced tumor growth and spread compared with either treatment alone.</p> <p><a href="/news-events/cancer-currents-blog/2024/pancreatic-cancer-kras-inhibitors-chemotherapy">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2024/jak-inhibitor-improves-cancer-immunotherapy"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2024-08/OCC-Jak-Mechanism-080224.jpg?h=79e9da77&itok=8W1QnDGa" width="228" height="171" alt="An illustration of a cytokine binding to a receptor on the cell surface and how it causes JAK proteins inside the cell to cause gene transcription. " /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2024/jak-inhibitor-improves-cancer-immunotherapy" onclick=""> <span>Drug Combo JAKs Up Immunotherapy in Two Clinical Trials</span> </a> <div class="description"> <div class="date-author"> <time datetime="2024-08-08T12:00:00Z">August 8, 2024</time>, by Nadia Jaber </div> <p>Scientists have been searching for ways to make immune checkpoint inhibitors work for more patients. In two trials, researchers explored a possible role for JAK inhibitors, which dampen chronic inflammation.</p> <p><a href="/news-events/cancer-currents-blog/2024/jak-inhibitor-improves-cancer-immunotherapy">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2024/kidney-cancer-mutational-signatures-geographic-variation"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2024-06/global-kidney-cancer-rates.jpg?h=d56bd17c&itok=4WraXYqI" width="228" height="171" alt="A map of the world showing rates of kidney cancer by country. The highest rates are in Lithuania, Czechia, and Uruguay.." /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2024/kidney-cancer-mutational-signatures-geographic-variation" onclick=""> <span>Tumor Signatures May Help Explain Global Differences in Kidney Cancer Rates</span> </a> <div class="description"> <div class="date-author"> <time datetime="2024-07-01T12:00:00Z">July 1, 2024</time>, by Edward Winstead </div> <p>By analyzing patterns of DNA mutations in kidney cancers from people around the world, researchers have discovered new clues about possible causes of the disease. Identifying these mutational signatures might lead to strategies for preventing kidney cancer.</p> <p><a href="/news-events/cancer-currents-blog/2024/kidney-cancer-mutational-signatures-geographic-variation">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2024/colorectal-cancer-fna-c2-bacteria"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2024-04/CC-Fusobacterium%20Nucleatum-V4.jpg?h=1e6eb8d0&itok=P6YxUdoM" width="228" height="171" alt="A silhouette of a human body showing Fna C2 bacterium in the mouth and a colon tumor." /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2024/colorectal-cancer-fna-c2-bacteria" onclick=""> <span>Scientists Link a Single Type of Bacteria to Colorectal Cancer</span> </a> <div class="description"> <div class="date-author"> <time datetime="2024-04-19T12:00:00Z">April 19, 2024</time>, by Sharon Reynolds </div> <p>NCI-funded researchers have pinpointed a single type of the bacterium F. nucleatum that appears to fuel the development and growth of colorectal cancer. In mice, the bacterium, Fna C2, appeared to cause more adenomas to form in the large intestine and it was often found in human tumor samples.</p> <p><a href="/news-events/cancer-currents-blog/2024/colorectal-cancer-fna-c2-bacteria">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2024/lonsurf-talzenna-cancer-tp53-mutations"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/thumbnail/2024-04/TP53-Factoid_4x3.png?itok=z9i32lgb" width="228" height="171" alt="" /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2024/lonsurf-talzenna-cancer-tp53-mutations" onclick=""> <span>Drug Combination May Have Potential for Cancers with TP53 Mutations</span> </a> <div class="description"> <div class="date-author"> <time datetime="2024-04-04T12:00:00Z">April 4, 2024</time>, by Nadia Jaber </div> <p>Although TP53 mutations help drive the growth of most cancers, there are no FDA-approved therapies that target altered p53 proteins. Now a drug combination has shown promise in mice and is being tested in a clinical trial.</p> <p><a href="/news-events/cancer-currents-blog/2024/lonsurf-talzenna-cancer-tp53-mutations">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2024/stress-cancer-metastasis-nets"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2024-03/NETs%20Max%20Plank.jpg?h=2bfee92b&itok=3CjvYZdU" width="228" height="171" alt="An electron microscope image of a neutrophil ejecting a NET that has captured bacteria" /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2024/stress-cancer-metastasis-nets" onclick=""> <span>Stress-Induced Immune Changes May Help Cancer Spread</span> </a> <div class="description"> <div class="date-author"> <time datetime="2024-04-02T12:00:00Z">April 2, 2024</time>, by Sharon Reynolds </div> <p>Stress-induced hormones called glucocorticoids can cause biological changes—in the form of sticky traps called NETs—that help create hospitable environments for cancer cells to form metastatic tumors, according to new research done largely in mice. </p> <p><a href="/news-events/cancer-currents-blog/2024/stress-cancer-metastasis-nets">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2024/gene-alteration-boosts-t-cell-therapy"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2024-03/CAR-T-cells.jpg?h=4d7c18be&itok=UZPnLhCJ" width="228" height="171" alt="An illustration of CAR t-cells and red blood cells on a red background" /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2024/gene-alteration-boosts-t-cell-therapy" onclick=""> <span>Stealing Strategies from Cancerous T Cells May Boost Immunotherapy</span> </a> <div class="description"> <div class="date-author"> <time datetime="2024-03-20T12:00:00Z">March 20, 2024</time>, by Sharon Reynolds </div> <p>Adding a fusion of parts of two genes helped engineered T cells divide faster, kill more tumor cells, and survive longer in mice without making the T cells behave like cancer cells.</p> <p><a href="/news-events/cancer-currents-blog/2024/gene-alteration-boosts-t-cell-therapy">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2024/radiation-cancer-bambi-immune-response"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2024-02/CC-Tumor%20Resistance.jpg?h=943bd3f8&itok=vQhE46X6" width="228" height="171" alt="An illustration depicting how gene therapy increases the amount of BAMBI in cells." /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2024/radiation-cancer-bambi-immune-response" onclick=""> <span>Manipulating an Immune Cell May Make Radiation Therapy More Effective, Study Suggests</span> </a> <div class="description"> <div class="date-author"> <time datetime="2024-02-12T12:00:00Z">February 12, 2024</time>, by Sharon Reynolds </div> <p>In a new study in mice, researchers showed they could enhance radiation therapy by boosting levels of the BAMBI protein in MDSC immune cells in the tumor microenvironment. After radiation, T cells flooded into the tumor and killed tumors elsewhere in the body.<br /> </p> <p><a href="/news-events/cancer-currents-blog/2024/radiation-cancer-bambi-immune-response">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2023/meningioma-gene-expression-signature"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2023-12/Cancer%20Currents-Meningioma.jpg?h=e591ebc8&itok=bG1mekTt" width="228" height="171" alt="An imaging scan of a brain with a meningioma highlighted in orange." /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2023/meningioma-gene-expression-signature" onclick=""> <span>Genetic Signature May Help Tailor Treatment for Meningioma</span> </a> <div class="description"> <div class="date-author"> <time datetime="2023-12-21T12:00:00Z">December 21, 2023</time>, by Sharon Reynolds </div> <p>The activity of 34 genes can accurately predict the aggressiveness of meningiomas, a new study shows. This gene expression signature may help oncologists select the best treatments for people with this common type of brain cancer than they can with current methods.</p> <p><a href="/news-events/cancer-currents-blog/2023/meningioma-gene-expression-signature">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2023/iga-antibody-inside-cancer-cells"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2023-12/KRAS-targeting%20IgA-d2.png?h=58af2066&itok=AtBHbRJp" width="228" height="171" alt="An illustration showing how IgA antibodies slip inside a cancer cell, latch onto abnormal proteins, and pull them out of the cell. " /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2023/iga-antibody-inside-cancer-cells" onclick=""> <span>Antibody Drug Ejects Problematic Proteins from Cancer Cells</span> </a> <div class="description"> <div class="date-author"> <time datetime="2023-12-13T12:00:00Z">December 13, 2023</time>, by Nadia Jaber </div> <p>Antibodies currently used in many cancer treatments have only been able to reach proteins outside of cancer cells. In a new study in mice, scientists found a way to target cancer-fueling KRAS and IDH1 proteins buried inside cancer cells.</p> <p><a href="/news-events/cancer-currents-blog/2023/iga-antibody-inside-cancer-cells">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2023/cancer-cells-steal-mitochondria-t-cells"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/thumbnail/2023-11/Mitochondrial%20Cancer%20Cell-Cancer%20Currents-Promo%20Image_0.jpg?itok=VTCC7KNd" width="228" height="171" alt="Illustration with T cells transferring mitochondria to cancer cells. The T cells, depicted in blue, contain mitochondria, shown as small pink shapes. A connection is shown between a T cell and a cancer cell, facilitating the transfer of mitochondria. Two cancer cells are depicted in pink, labeled as "Mitochondrial Receiver Cancer Cell" and "Cancer Cell."" /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2023/cancer-cells-steal-mitochondria-t-cells" onclick=""> <span>Molecular Burglary: Cancer Cells Hijack Energy from Immune Cells</span> </a> <div class="description"> <div class="date-author"> <time datetime="2023-11-21T12:00:00Z">November 21, 2023</time>, by Sharon Reynolds </div> <p>A new study shows that, in some tumors, a subset of cancer cells can drain mitochondria, the tiny structures within cells that produce energy, from T cells and use them for their own energy needs.</p> <p><a href="/news-events/cancer-currents-blog/2023/cancer-cells-steal-mitochondria-t-cells">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2023/immunotherapy-mismatch-repair-biomarker"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2023-10/Heterogeneity%20and%20ICIs-high%20res.png?h=a3d3af65&itok=IcDNlnsd" width="228" height="171" alt="A tumor with multicolored cells on the left surrounded by gray immune cells. On the right, a tumor with nearly all yellow cells, surrounded by green immune cells." /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2023/immunotherapy-mismatch-repair-biomarker" onclick=""> <span>A Better Biomarker for Cancer Immunotherapy?</span> </a> <div class="description"> <div class="date-author"> <time datetime="2023-11-03T12:00:00Z">November 3, 2023</time>, by Nadia Jaber </div> <p>A new study, conducted largely in mice, may help explain why a currently used molecular marker—called mismatch repair deficiency—doesn’t always work to predict which patients will respond to immunotherapies called immune checkpoint inhibitors.</p> <p><a href="/news-events/cancer-currents-blog/2023/immunotherapy-mismatch-repair-biomarker">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2023/colorectal-cancer-enlace-hispanic-latino"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2023-10/Reinosa%20ENLACE_1.jpg?h=dbab2b0c&itok=CqV8Pae1" width="228" height="171" alt="A picture of Adan Reinosa in his garage with a piece of a car engine." /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2023/colorectal-cancer-enlace-hispanic-latino" onclick=""> <span>ENLACE Study Explores Colorectal Cancer in Hispanic and Latino People</span> </a> <div class="description"> <div class="date-author"> <time datetime="2023-10-18T12:00:00Z">October 18, 2023</time>, by Edward Winstead </div> <p>The ENLACE study is the first to use cutting-edge technologies to describe the molecular features of colorectal tumors in Hispanic and Latino people. The study’s goals are to improve treatments and increase Hispanic/Latino engagement in cancer research.</p> <p><a href="/news-events/cancer-currents-blog/2023/colorectal-cancer-enlace-hispanic-latino">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2023/oncolytic-virus-blocking-tgf-beta"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2023-10/Modified%20Oncolytic%20Virus-Cancer-Currents-Image_0.png?h=1e1d4eb1&itok=0GpPt7eA" width="228" height="171" alt="Illustration depicting the interaction between a modified oncolytic virus, tumor cells, and cancer-fighting T cells. The virus causes tumor cell rupture and releases TGFβ blockers, which inhibit Treg cells, thereby enhancing the efficacy of T cells in fighting cancer." /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2023/oncolytic-virus-blocking-tgf-beta" onclick=""> <span>Oncolytic Virus Enables the Immune System to Attack Tumors</span> </a> <div class="description"> <div class="date-author"> <time datetime="2023-10-12T12:00:00Z">October 12, 2023</time>, by Shana Spindler </div> <p>A cancer-infecting virus engineered to tamp down a tumor’s ability to suppress the immune system shrank tumors in mice, a new study shows. The modified oncolytic virus worked even better when used along with an immune checkpoint inhibitor.</p> <p><a href="/news-events/cancer-currents-blog/2023/oncolytic-virus-blocking-tgf-beta">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2023/universal-car-t-cell-blood-cancer"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2023-09/AML%20cells%20illustration.jpg?h=0cf3877f&itok=HPmz3AIt" width="228" height="171" alt="An illustration of AML cells floating among other cells" /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2023/universal-car-t-cell-blood-cancer" onclick=""> <span>Researchers Develop a Potential “Universal” CAR T-Cell Therapy for Blood Cancers</span> </a> <div class="description"> <div class="date-author"> <time datetime="2023-09-27T12:00:00Z">September 27, 2023</time>, by Carmen Phillips </div> <p>Researchers have used a form of CRISPR, called base editing, to engineer T cells and hematopoietic stem cells as part of a potential “universal” CAR T-cell therapy for blood cancers. In experiments in mice, the treatment rapidly eliminated tumors, including in mice with acute myeloid leukemia (AML).</p> <p><a href="/news-events/cancer-currents-blog/2023/universal-car-t-cell-blood-cancer">Continue Reading ></a></p> </div> </div> </li> </li> <li> <li class="general-list-item general list-item"> <div class="list-item-image image container"> <a class="item-image image" href="/news-events/cancer-currents-blog/2023/rewiring-cancer-cells-self-destruct"> <img loading="lazy" src="/sites/g/files/xnrzdm211/files/styles/cgov_thumbnail/public/cgov_image/media_image/2023-08/Transcriptional%20Chemical%20Inducer%20of%20Proximity-high%20res.png?h=53000b3c&itok=T0cIN0Tc" width="228" height="171" alt="A red bean shape on DNA labeled "cell death gene" with the words ON and an arrow pointing to a dividing cell. Below, Red and green bean shapes with a squiggly line connecting them and labeled "TCIP1". The word ON and an arrow pointing to a dead cell." /> </a> </div> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2023/rewiring-cancer-cells-self-destruct" onclick=""> <span>New Class of Compounds Rewires Cancer Cells to Self-Destruct</span> </a> <div class="description"> <div class="date-author"> <time datetime="2023-08-29T12:00:00Z">August 29, 2023</time>, by Nadia Jaber </div> <p>Researchers have created a molecule that, in cancer cells, hooks onto the protein BCL6 at one end and another protein that turns genes on at the other end. The result: self-destruct genes are turned up, causing the cancer cells to die.</p> <p><a href="/news-events/cancer-currents-blog/2023/rewiring-cancer-cells-self-destruct">Continue Reading ></a></p> </div> </div> </li> </li> </ul> </div> <div class="blog-pager clearfix"> <a class="older" href="/news-events/cancer-currents-blog?topic=biology&page=1">< Older Posts</a> </div> </div> </div> </ul> </div> </div> </div> </div> <footer class="article-footer"> </footer> </article>  </div> </main> </div>   <div class="cgdpl desktop:grid-col-3"> <div id="nvcgSlListBlogRTRail" class="right-rail"> <div class="slot-item"> <div class="managed list with-date"> <h2 id="Featured+Posts">Featured Posts</h2> <ul> <li class="general-list-item general list-item"> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2024/medical-cannabis-oncologists-patients-communication">Oncologists Struggle to Answer Questions About Medical Cannabis</a> <div class="byline"> <p> October 16, 2024, by Carmen Phillips </p> </div> </div> </li> <li class="general-list-item general list-item"> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2024/mammogram-false-positives-affect-future-screening">Mammogram False Positives Can Affect Future Screening Behavior</a> <div class="byline"> <p> October 4, 2024, by Edward Winstead </p> </div> </div> </li> <li class="general-list-item general list-item"> <div class="title-and-desc title desc container"> <a class="title" href="/news-events/cancer-currents-blog/2024/ancient-retrovirus-dna-ltr10-cancer">DNA From an Ancient Virus Helps Many Cancers Grow</a> <div class="byline"> <p> September 6, 2024, by Nadia Jaber </p> </div> </div> </li> </ul> </div> </div> <div class="slot-item"> <div class="managed list without-date"> <h2 id="Categories">Categories</h2> <ul> <li class="general-list-item general list-item"> <div class="title-and-desc title desc 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href="/news-events/cancer-currents-blog?year=2024&month=04"> April </a> (6) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2024&month=03"> March </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2024&month=02"> February </a> (6) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2024&month=01"> January </a> (6) </li> </ul> <h3> 2023 </h3> <ul class="ui-helper-reset"> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2023&month=12"> December </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2023&month=11"> November </a> (6) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2023&month=10"> October </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2023&month=09"> September </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2023&month=08"> August </a> (6) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2023&month=07"> July </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2023&month=06"> June </a> (8) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2023&month=05"> May </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2023&month=04"> April </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2023&month=03"> March </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2023&month=02"> February </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2023&month=01"> January </a> (6) </li> </ul> <h3> 2022 </h3> <ul class="ui-helper-reset"> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2022&month=12"> December </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2022&month=11"> November </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2022&month=10"> October </a> (5) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2022&month=09"> September </a> (6) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2022&month=08"> August </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2022&month=07"> July </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2022&month=06"> June </a> (8) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2022&month=05"> May </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2022&month=04"> April </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2022&month=03"> March </a> (8) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2022&month=02"> February </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2022&month=01"> January </a> (6) </li> </ul> <h3> 2021 </h3> <ul class="ui-helper-reset"> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2021&month=12"> December </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2021&month=11"> November </a> (4) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2021&month=10"> October </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2021&month=09"> September </a> (9) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2021&month=08"> August </a> (6) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2021&month=07"> July </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2021&month=06"> June </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2021&month=05"> May </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2021&month=04"> April </a> (8) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2021&month=03"> March </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2021&month=02"> February </a> (5) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2021&month=01"> January </a> (6) </li> </ul> <h3> 2020 </h3> <ul class="ui-helper-reset"> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2020&month=12"> December </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2020&month=11"> November </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2020&month=10"> October </a> (8) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2020&month=09"> September </a> (6) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2020&month=08"> August </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2020&month=07"> July </a> (9) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2020&month=06"> June </a> (8) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2020&month=05"> May </a> (8) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2020&month=04"> April </a> (10) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2020&month=03"> March </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2020&month=02"> February </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2020&month=01"> January </a> (7) </li> </ul> <h3> 2019 </h3> <ul class="ui-helper-reset"> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2019&month=12"> December </a> (6) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2019&month=11"> November </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2019&month=10"> October </a> (8) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2019&month=09"> September </a> (8) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2019&month=08"> August </a> (6) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2019&month=07"> July </a> (8) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2019&month=06"> June </a> (6) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2019&month=05"> May </a> (9) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2019&month=04"> April </a> (7) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2019&month=03"> March </a> (10) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2019&month=02"> February </a> (9) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2019&month=01"> January </a> (6) </li> </ul> <h3> 2018 </h3> <ul class="ui-helper-reset"> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2018&month=12"> December </a> (9) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2018&month=11"> November </a> (9) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2018&month=10"> October </a> (9) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2018&month=09"> September </a> (11) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2018&month=08"> August </a> (9) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2018&month=07"> July </a> (9) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2018&month=06"> June </a> (12) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2018&month=05"> May </a> (9) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2018&month=04"> April </a> (10) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2018&month=03"> March </a> (11) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2018&month=02"> February </a> (11) </li> <li class="month"> <a href="/news-events/cancer-currents-blog?year=2018&month=01"> January </a> (10) </li> </ul> </div> </div> </div> </div> </div> </div>  </div> <section class="cgdp-page-options cgdp-page-options--bottom" aria-label="Page options bottom"> <button class="usa-button usa-button--unstyled" onclick="window.print()"> <svg xmlns="http://www.w3.org/2000/svg" height="24" viewBox="0 0 24 24" width="24" class="usa-icon" role="img" aria-hidden="true" focusable="false"> <path d="M0 0h24v24H0z" fill="none"/> <path d="M19 8H5c-1.66 0-3 1.34-3 3v6h4v4h12v-4h4v-6c0-1.66-1.34-3-3-3zm-3 11H8v-5h8v5zm3-7c-.55 0-1-.45-1-1s.45-1 1-1 1 .45 1 1-.45 1-1 1zm-1-9H6v4h12V3z"/> </svg> <span 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