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data-node="5df7a79c323fc"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-divider fl-node-5df7a79c323fe" data-node="5df7a79c323fe"> <div class="fl-module-content fl-node-content">  <div class="divider "></div> </div> </div> </div> </div> </div> </div> </div> </div> </header> <div id="fl-main-content" class="fl-page-content" itemprop="mainContentOfPage" role="main"> <div class="fl-content-full container"> <div class="row"> <div class="fl-content col-md-12"> <article class="fl-post post-12043 page type-page status-publish has-post-thumbnail hentry" id="fl-post-12043" itemscope="itemscope" itemtype="https://schema.org/CreativeWork"> <div class="fl-post-content clearfix" itemprop="text"> <div class="fl-builder-content fl-builder-content-12043 fl-builder-content-primary fl-builder-global-templates-locked" data-post-id="12043"><div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-6180060ce59ba fl-row-default-height fl-row-align-center" data-node="6180060ce59ba"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-6180060ce6d93" data-node="6180060ce6d93"> <div class="fl-col fl-node-6180060ce6e38 fl-col-bg-color fl-col-small" data-node="6180060ce6e38"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-link fl-node-618006c57caa4" data-node="618006c57caa4"> <div class="fl-module-content fl-node-content"> <a href="https://worldadc-europe.com/whats-on/day-one/" id="ee-link-618006c57caa4"> <div class="eehw-link"> <div class="link-url"> <h2>Day One</h2> </div> <div class="link-date"> <p>Tuesday 4th March, 2025</p> </div> </div> </a> </div> </div> </div> </div> <div class="fl-col fl-node-6180060ce6e3c fl-col-bg-color fl-col-small" data-node="6180060ce6e3c"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-link fl-node-6180072ec7343" data-node="6180072ec7343"> <div class="fl-module-content fl-node-content"> <a href="https://worldadc-europe.com/whats-on/day-two/" id="ee-link-6180072ec7343"> <div class="eehw-link"> <div class="link-url"> <h2>Day Two</h2> </div> <div class="link-date"> <p>Wednesday 5th March, 2025</p> </div> </div> </a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-j0b6sncv2t1r fl-row-default-height fl-row-align-center" data-node="j0b6sncv2t1r"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-kdrmwo8l4y27" data-node="kdrmwo8l4y27"> <div class="fl-col fl-node-by9wrg47ojul fl-col-bg-color" data-node="by9wrg47ojul"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-wket6s7iojun" data-node="wket6s7iojun"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 7:30 am </span> Check In, Morning Coffee & Light Refreshments </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 8:20 am </span> Chair’s Opening Remarks </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23871" class="view-speaker" speaker-id="23871"><span>Robert Lutz</span></a></em> Chief Scientific Officer, Iksuda Therapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> <center><span style="font-size: 20px;"><span style="color: #990582;">Evaluating Novel ADC Formats & Payloads in the Clinic – How Do They Perform Against Classical ADCs?</span></center> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 8:30 am </span> Investigating the Clinical Performance of Zelenectide Pevedotin & BT5528 to Understand Class Effect Differences of Bicycle Toxin Conjugates Against Classical ADC Formats </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23898" class="view-speaker" speaker-id="23898"><span>Gavin Bennett</span></a></em> Senior Director, Drug Development, Bicycle Therapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Laying out the emerging safety profiles of zelenectide pevedotin and BT5528, and comparing toxicity characterisation against classical ADC formats</p> <p>• Delving into BT5528 clinical toxicity profile against EphA2 in contrast to ADCs against the same target</p> <p>• Rationalising preclinical and clinical differences with PKPD analysis and understanding the advantages of BTCs design and performance</p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 9:00 am </span> Versatile & Robust Chemical Site-Specific Conjugation Platform: AJICAP® Technology </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23899" class="view-speaker" speaker-id="23899"><span>Tomohiro Fujii</span></a></em> ADC Researcher, Ajinomoto Bio-Pharma Services </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• AJICAP® Conjugation: Examining how site-specific technologies are being employed in many of the next-generation ADCs due to the enhancement of clinically relevant biological properties observed in various preclinical studies</p> <p>• AJICAP® Linker: Demonstrating a novel hydrophilic linker technology that enables the versatile synthesis of homogenous DAR = 1, 2, 4, 8, and higher</p> <p>• Showcasing bispecific and trispecific antibodies produced by a fully chemical conjugation technology</p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 9:30 am </span> Detailing Clinical Development of OncoFAP: a Small Molecule Conjugate Targeting Fibroblast Activation Protein in Solid Tumours </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23900" class="view-speaker" speaker-id="23900"><span>Andrea Galbiati</span></a></em> Group Leader, Philochem </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Exploring ongoing OncoFAP tumour target activity in first-in-human imaging studies in solid tumours</p> <p>• Assessing OncoFAP anti-tumour response as a monotherapy and in combination with immunotherapies</p> <p>• Contrasting anti-cancer properties of small-molecule conjugates against antibody-drug conjugates</p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 10:00 am </span> Morning Break & Networking </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> </div> </div> </div> <div class="fl-module fl-module-tabs fl-node-ubx5fyle9dz3" data-node="ubx5fyle9dz3"> <div class="fl-module-content fl-node-content"> <div class="fl-tabs fl-tabs-vertical fl-clearfix"> <div class="fl-tabs-labels fl-clearfix" role="tablist"> <a href="#" class="fl-tabs-label fl-tab-active" id="fl-tabs-ubx5fyle9dz3-label-0" data-index="0" aria-selected="true" aria-controls="fl-tabs-ubx5fyle9dz3-panel-0" aria-expanded="true" role="tab" tabindex="0"> <span style="font-size: 18px; color: #ac7194;"><strong>Discovery</strong></span> </a> <a href="#" class="fl-tabs-label" id="fl-tabs-ubx5fyle9dz3-label-1" data-index="1" aria-selected="false" aria-controls="fl-tabs-ubx5fyle9dz3-panel-1" aria-expanded="false" role="tab" tabindex="0"> <span style="font-size: 18px; color: #2B2A87;"><strong>Preclinical & Translational</strong></span> </a> <a href="#" class="fl-tabs-label" id="fl-tabs-ubx5fyle9dz3-label-2" data-index="2" aria-selected="false" aria-controls="fl-tabs-ubx5fyle9dz3-panel-2" aria-expanded="false" role="tab" tabindex="0"> <span style="font-size: 18px; color: #E31E26;"><strong>Clinical Lessons</strong></span> </a> <a href="#" class="fl-tabs-label" id="fl-tabs-ubx5fyle9dz3-label-3" data-index="3" aria-selected="false" aria-controls="fl-tabs-ubx5fyle9dz3-panel-3" aria-expanded="false" role="tab" tabindex="0"> <span style="font-size: 18px; color: #973E97;"><strong>Process & Analytical Development</strong></span> </a> <a href="#" class="fl-tabs-label" id="fl-tabs-ubx5fyle9dz3-label-4" data-index="4" aria-selected="false" aria-controls="fl-tabs-ubx5fyle9dz3-panel-4" aria-expanded="false" role="tab" tabindex="0"> <span style="font-size: 18px; color: #656568;"><strong>Manufacturing & Supply Chain</strong></span> </a> </div> <div class="fl-tabs-panels fl-clearfix"> <div class="fl-tabs-panel"> <div class="fl-tabs-label fl-tabs-panel-label fl-tab-active" data-index="0" tabindex="0"> <span><span style="font-size: 18px; color: #ac7194;"><strong>Discovery</strong></span></span> <i class="fas"></i> </div> <div class="fl-tabs-panel-content fl-clearfix fl-tab-active" id="fl-tabs-ubx5fyle9dz3-panel-0" data-index="0" aria-labelledby="fl-tabs-ubx5fyle9dz3-label-0" role="tabpanel" aria-live="polite"> <p style="text-align: center;"><span style="font-size: 18px; color: #ac7194;"><strong>Discovery</strong></span></p> <p style="text-align: center;"><strong>Chair</strong>: <em><strong>Lenka Sadilkova</strong>, Director, Non-Clinical Projects, <strong>Mablink</strong><br /> <strong>Bioscience, an Eli Lilly Subsidiary</strong></em></p> <p style="text-align: center;"><span style="color: #a91970;"><a style="color: #a91970;" href="https://worldadc-europe.com/whats-on/full-event-guide/"><em>Download the Full Event Guide for full details</em></a></span></p> <hr /> <p style="text-align: center;"><span style="color: #ac7294;"><strong>Showcasing Challenges & Opportunities in Novel Conjugate Design & Development</strong></span></p> <hr /> <p><span style="color: #ac7194;"><strong>11.00 am</strong></span><strong> Bispecific & Biparatopic Antibody Drug Conjugates: Evaluating Strategies & Challenges</strong></p> <p>• Exploring BpAbs and BpADCs MoA beyond classical antibodies<br /> such as enhanced avidity binding, locking receptor conformation, faster internalisation and payload delivery to low cancer cell populations<br /> • Engaging multiple antigens and cells simultaneously by bispecific ADCs to elicit synergistic effects such as killing a broader spectrum of tumour cells and promoting payload uptake<br /> • Discussing BpADCs and BsADCs design and formats, target and linkerpayload selections, clinical status and limitations</p> <p><span style="color: #ac7194;"><strong>Alain Beck</strong>, Senior Director, Biologics CMC Developability,<strong> Pierre Fabre</strong></span></p> <hr /> <p><strong><span style="color: #ac7194;">11.30 am<span style="color: #000000;"> Showcasing Enhanced Tumour Penetration & Activity of Antibody Fragment Conjugates Using Novel Site-Specific Conjugation<br /> </span></span></strong></p> <p>• Introducing novel site-specific conjugation technology allowing one-step conjugation and simplification of in-process testing<br /> • Applying one-step conjugation to antibody variable region to develop fragment-drug conjugates<br /> • Assessing increased tumour penetration and activity properties of fragment conjugates against HER2 and EGFR/cMET</p> <p><span style="color: #ac7194;"><strong>NingNing Ma</strong>, Professor, <strong>Shenyang Pharmaceutical University</strong></span></p> <hr /> <p><strong><span style="color: #ac7194;">12.00 pm</span> Roundtable Session: ADCs vs Novel Conjugates – What are the Pros & Cons of Novel Payload & Targeting Moiety Development?</strong></p> <p>• What progress has been made and what is yet to be demonstrated across DACs, ISACs, and other non-cytotoxic payloads?<br /> • Debating the advantages and disadvantages of novel targeting moiety conjugate development<br /> • What are the bottlenecks preventing novel conjugates matching classical ADCs?</p> <hr /> <p><span style="color: #f9af1f;"><strong><span style="color: #f9af1f;">12.30 pm Lunch & Learn Sessions Presented by </span></strong></span></p> <p><img decoding="async" class="aligncenter" src="https://encrypted-tbn0.gstatic.com/images?q=tbn:ANd9GcTyLOffT9OU0YkN_J_HK_HnW3Dfwajxjb6gpQ&s" alt="Merck KGaA Logo Purple transparent PNG - StickPNG" width="159" height="89" /></p> <hr /> <p style="text-align: center;"><span style="color: #ac7294;"><strong>Innovating Linker Chemistry to Widen Applications & Maximise Tumour Payload Delivery</strong></span></p> <hr /> <p><strong><span style="color: #ac7194;">1.30 pm</span> Leveraging Glycan Linker Chemistry & Site-Specific Conjugation to Improve ADC Performance</strong></p> <p>• Understanding the current limitations of linker chemistry on ADC properties<br /> • Considering the biophysical characterisation of ADCs with different linker design and conjugation site<br /> • Discussing how glycan site-specific conjugation can improve the performance of ADCs</p> <p><span style="color: #ac7194;"><strong>David Huang</strong>, Head, Medicinal Chemistry, <strong>OBI Pharma</strong></span></p> <hr /> <p><strong><span style="color: #ac7194;">2.00 pm</span> Linker-Payload Design & ADC Human MTD: Progressing from Chemistry to the Clinic</strong></p> <p>• Evaluating T-moiety linkers for hydrophobic payloads e.g. exatecan to overcome resistance and expand the therapeutic window of ADCs<br /> • Explaining implications of liker chemistry in preclinical in vivo efficacy and safety<br /> • Contextualising impact on human MTD from ongoing clinical studies</p> <p><span style="color: #ac7194;"><strong>Xiaona Jing</strong>, Senior Vice President, Global Product Development & Partnering, <strong>Multitude Therapeutics</strong></span></p> </div> </div> <div class="fl-tabs-panel"> <div class="fl-tabs-label fl-tabs-panel-label" data-index="1" tabindex="0"> <span><span style="font-size: 18px; color: #2B2A87;"><strong>Preclinical & Translational</strong></span></span> <i class="fas fa-plus"></i> </div> <div class="fl-tabs-panel-content fl-clearfix" id="fl-tabs-ubx5fyle9dz3-panel-1" data-index="1" aria-hidden="true" aria-labelledby="fl-tabs-ubx5fyle9dz3-label-1" role="tabpanel" aria-live="polite"> <p style="text-align: center;"><span style="font-size: 18px; color: #2b2a87;"><strong>Preclinical & Translational</strong></span></p> <p style="text-align: center;"><strong>Chair:</strong><em><strong> Rakesh Dixit</strong>, President & Chief Executive Officer,<strong> Bionavigen Oncology</strong></em></p> <p style="text-align: center;"><span style="color: #a91970;"><a style="color: #a91970;" href="https://worldadc-europe.com/whats-on/full-event-guide/"><em>Download the Full Event Guide for full details</em></a></span></p> <hr /> <p style="text-align: center;"><span style="font-size: 18px; color: #2b2a87;"><strong>Assessing ADC Non-Clinical PK/PD to Characterise ADC Mechanism & Predict Clinical Activity</strong></span></p> <hr /> <p><strong><span style="color: #2b2a87;">11.00 am</span> Showcasing Design & Translational Development of<br /> Anti-PDL1 ADC with Enhanced Internalisation Properties</strong></p> <p>• Explaining biology and preclinical development of anti-PDL1 ADC<br /> • Engineering ADC properties for increased ADC internalisation paired with payload sensitive to immune cells<br /> • Evaluating emerging clinical performance from dose escalation studies</p> <p><strong><span style="color: #2b2a87;">Garrett Cornelison</span></strong><span style="color: #2b2a87;">, Senior Principal </span><span style="color: #2b2a87;">Scientist,</span><strong><span style="color: #2b2a87;"> Pfizer</span></strong></p> <hr /> <p><strong><span style="color: #2b2a87;">11.30 am</span> Exploring Preclinical Characterisation of pH Dependent AnticMET ADC MYTX-011 Designed for Enhanced Tumour Delivery</strong></p> <p>• Outlining rationale and engineering of MYTX-011, a cMET targeting ADC<br /> • Assessing comprehensive preclinical <em>in vitro</em> and <em>in vivo </em>characterisation in various animal models<br /> • Evaluating MYTX-011 PK data and safety in non-human primates</p> <p><span style="color: #2b2a87;"><strong>Nimish Gera</strong>, Vice President, Biologics, <strong>Mythic Therapeutics</strong></span></p> <hr /> <p><strong><span style="color: #2b2a87;">12.00 pm</span> Roundtable Session: Debating Strategy & Characterisation to Best Predict ADC Performance in the Clinic</strong></p> <p>• Breaking down translational considerations to derive ADC tolerability and therapeutic index in the clinic<br /> • Balancing ADC efficacy and safety to widen the therapeutic index<br /> • Gleaning comprehensive insights from <em>in vivo</em> and <em>in vitro</em> investigation to best predict clinical toxicities</p> <hr /> <p><span style="color: #f9af1f;"><strong>12.30 pm Lunch & Learn Sessions Presented by </strong></span></p> <p><img decoding="async" class="aligncenter" src="https://encrypted-tbn0.gstatic.com/images?q=tbn:ANd9GcTyLOffT9OU0YkN_J_HK_HnW3Dfwajxjb6gpQ&s" alt="Merck KGaA Logo Purple transparent PNG - StickPNG" width="159" height="89" /></p> <hr /> <p style="text-align: center;"><span style="color: #2b2a87;"><strong>Diving into Translational Development of Novel ADC Linker-Payload Designs</strong></span></p> <hr /> <p><strong><span style="color: #2b2a87;">1.30 pm</span> Evaluating Comprehensive Preclinical Development of IKS04: the First Anti-CA242 Ultra-Low DAR ADC Against Solid Tumours</strong></p> <p>• Introducing IKS04 ultra-low DAR approach co-dosed with antibodies<br /> • Applying concepts of increased tumour penetration to highly potent PBDnprodrug payloads<br /> • Reviewing the preclinical profile of IKS04 targeting GI solid tumours and highlighting future plans for clinical investigation</p> <p><strong><span style="color: #2b2a87;">Jutta Deckert, Vice President, Research & Development, Iksuda Therapeutics</span></strong></p> <hr /> <p><strong><span style="color: #2b2a87;">2.00 pm</span> Broad-Spectrum Efficacy of CEACAM6-Targeted ADC with BET Protein Degrader in Colorectal, Lung & Breast Cancer Models</strong></p> <p>• Developing a novel ADC targeting CEACAM6 for delivery of a BET protein degrader<br /> • Demonstrating potent and broadspectrum efficacy in CRC, BC, and LC models<br /> • Discussing the effects of combination therapy with immune checkpoint inhibitors</p> <p><strong><span style="color: #2b2a87;">Hiroyuki Kogai</span></strong><span style="color: #2b2a87;">, Scientist,</span><strong><span style="color: #2b2a87;"> Eisai</span></strong></p> </div> </div> <div class="fl-tabs-panel"> <div class="fl-tabs-label fl-tabs-panel-label" data-index="2" tabindex="0"> <span><span style="font-size: 18px; color: #E31E26;"><strong>Clinical Lessons</strong></span></span> <i class="fas fa-plus"></i> </div> <div class="fl-tabs-panel-content fl-clearfix" id="fl-tabs-ubx5fyle9dz3-panel-2" data-index="2" aria-hidden="true" aria-labelledby="fl-tabs-ubx5fyle9dz3-label-2" role="tabpanel" aria-live="polite"> <p style="text-align: center;"><span style="font-size: 18px; color: #e31e26;"><strong><span style="color: #e31e26;">Clinical Lessons</span></strong></span></p> <p style="text-align: center;"><strong>Chair: <em>Gilles Gallant</em></strong><em>, Chief Development Officer, <strong>Mythic Therapeutics</strong></em></p> <p style="text-align: center;"><span style="color: #a91970;"><a style="color: #a91970;" href="https://worldadc-europe.com/whats-on/full-event-guide/"><em>Download the Full Event Guide for full details</em></a></span></p> <hr /> <p style="text-align: center;"><span style="font-size: 18px; color: #e31e26;"><strong><span style="color: #e31e26;">Assessing Clinically Effective ADCs - What are the Lessons Learnt for the Future?</span></strong></span></p> <hr /> <p><span style="color: #e31e26;"><strong>11.00 am</strong></span> <strong>Assessing Dose Escalation & Emerging Clinical Data of AGX101 Targeting TM4SF1 & Tumour Vasculature</strong></p> <p>• Outlining initial dose escalation results of AGX101<br /> • Investigating different mechanisms of action and emerging efficacy and safety across different dose levels<br /> • Relating target biology to the clinic and validating TM4SF1 as a drug target against tumour vasculature</p> <p><span style="color: #e31e26;"><strong>Paul Jaminet</strong>, Chief Executive Officer, <strong>Angiex</strong></span></p> <hr /> <p><span style="color: #e31e26;"><strong>11.30 am</strong></span> Applying Learnings From Clinical Development of SQ3370 to Optimise Development of Novel Tumour-Targeted Therapies</p> <p>• Discussing safety and efficacy results from the phase 2 clinical programme of SQ3370<br /> • Reviewing learnings from the clinical study and how they have informed design principles going forward<br /> • Highlighting data from Shasqi’s lead asset targeting CEACAM5</p> <p><span style="color: #e31e26;"><strong>Travis Biechele</strong>, Vice President, Research, <strong>Shasqi</strong></span></p> <hr /> <p><strong><span style="color: #e31e26;">12.00 pm</span> Roundtable Session Delving into Biomarker-Based & Precision Medicine ADC Development Approaches</strong></p> <p>• Exploring the need for precision medicine ADC development in an<br /> increasingly saturated target market<br /> • Navigating challenges with clinical recruitment cut-offs to select patients to benefit from specific ADCs<br /> • Evaluating diagnostic methods and technologies to narrow ADC patient populations</p> <hr /> <p><span style="color: #f9af1f;"><strong>12.30 pm Lunch & Learn Sessions Presented by </strong></span></p> <p><img decoding="async" class="aligncenter" src="https://encrypted-tbn0.gstatic.com/images?q=tbn:ANd9GcTyLOffT9OU0YkN_J_HK_HnW3Dfwajxjb6gpQ&s" alt="Merck KGaA Logo Purple transparent PNG - StickPNG" width="159" height="89" /></p> <hr /> <p style="text-align: center;"><span style="font-size: 18px; color: #e31e26;"><strong><span style="color: #e31e26;">Showcasing & Contextualising Cutting-Edge ADC Clinical<br /> Performance & Trial Design</span></strong></span></p> <hr /> <p><strong><span style="color: #e31e26;">1.30 pm</span> Felmetatug Vedotin is a B7H4-Targeted Vedotin ADC with Immunomodulatory Activity & Combines with an Anti-PD1 in Preclinical Models</strong></p> <p>• Felmetatug vedotin is a B7-H4-targeted ADC using the clinically validated vedotin payload/linker system<br /> • B7H4V induces immunogenic cell death and combines with anti-PD1 in preclinical models demonstrating improved anti-tumour effect<br /> • In a Phase 1 study, FV has shown promising activity and a manageable safety profile in heavily pretreated patients, unselected for target expression</p> <p><strong><span style="color: #e31e26;">Paromita Raha</span></strong><span style="color: #e31e26;">, Principal Scientist, </span><strong><span style="color: #e31e26;">Pfizer</span></strong></p> <hr /> <p><strong><span style="color: #e31e26;">2.00 pm</span> Cross Border Mindset as a Key Success Factor for Rapid & High- Quality Clinical Development of ADCs</strong></p> <p>• What is different in the development of an ADC as opposed to other molecules, and why does it matter?<br /> • Evaluating cross-border mindset and partnerships as key tools to accelerate clinical development of ADCs<br /> • Exploring case studies of ADC clinical development</p> <p><span style="color: #e31e26;"><strong>Maria Dahl</strong>, Chief Operating Officer & Head, Europe, <strong>Innovent Biologics</strong></span></p> </div> </div> <div class="fl-tabs-panel"> <div class="fl-tabs-label fl-tabs-panel-label" data-index="3" tabindex="0"> <span><span style="font-size: 18px; color: #973E97;"><strong>Process & Analytical Development</strong></span></span> <i class="fas fa-plus"></i> </div> <div class="fl-tabs-panel-content fl-clearfix" id="fl-tabs-ubx5fyle9dz3-panel-3" data-index="3" aria-hidden="true" aria-labelledby="fl-tabs-ubx5fyle9dz3-label-3" role="tabpanel" aria-live="polite"> <p style="text-align: center;"><span style="font-size: 18px; color: #973e97;"><strong>Proc<span style="color: #973e97;">es</span>s & Analytical Development</strong></span></p> <p style="text-align: center;"><strong>Chair: <em>Paul Wolstenholme-Hogg</em></strong><em>, </em><em>Vice President, Medicinal Chemistry, </em><strong><em>ADC Therapeutics</em></strong></p> <p style="text-align: center;"><span style="color: #a91970;"><a style="color: #a91970;" href="https://worldadc-europe.com/whats-on/full-event-guide/"><em>Download the Full Event Guide for full details</em></a></span></p> <hr /> <p style="text-align: center;"><span style="font-size: 18px; color: #973e97;"><strong>Navigating Development & Validation of Biological Assays to Assess ADC Properties</strong></span></p> <hr /> <p><strong><span style="color: #973e97;">11.00 am</span> Detailing Bioassay Development & Applications in ADC Characterisation </strong><strong>& Lot Release</strong></p> <p>• Exploring bioassays in place to support ongoing ADC development and characterisation<br /> • Looking to the future – how much more can bioassays be used for ADC analysis?<br /> • Explaining how bioassays fit into lotrelease and process</p> <p><span style="color: #973e97;"><strong>Uchechukwu Okorji-Obike</strong>, Senior Scientist, Bioassay Development, <strong>AstraZeneca</strong></span></p> <hr /> <p><strong><span style="color: #973e97;">11.30 am</span> Intact Mass Analysis to Investigate <em>In Vitro</em> &<em> In Vivo</em> ADC Properties ease</strong></p> <p>• Leveraging hybrid immunocapture and HR-MS methods to assess ADC properties<br /> • Investigating applications for in vivo DAR determination<br /> • Investigating ADC stability characterisation</p> <p><strong><span style="color: #973e97;">Federico Riccardi Sirtori</span></strong><span style="color: #973e97;">, Director & </span><span style="color: #973e97;">Head, NBE-DMPK Innovative Bioanalytics, </span><strong><span style="color: #973e97;">Merck KGaA</span></strong></p> <hr /> <p><strong><span style="color: #973e97;">12.00 pm</span></strong> <strong>Roundtable Session: Discussing the Unique Challenges of ADC Cell-Based Assay Development Across Molecule Complexity & MoA</strong></p> <p>• Outlining the unique challenges facing ADC potency assay development<br /> • What are the regulatory expectations for ADC cell-based assays, and what guidance could be made clearer?<br /> • Exploring opportunities for standardised cell-based assay approaches</p> <hr /> <p><span style="color: #f9af1f;"><strong>12.30 pm Lunch & Learn Sessions Presented by </strong></span></p> <p><img decoding="async" class="aligncenter" src="https://encrypted-tbn0.gstatic.com/images?q=tbn:ANd9GcTyLOffT9OU0YkN_J_HK_HnW3Dfwajxjb6gpQ&s" alt="Merck KGaA Logo Purple transparent PNG - StickPNG" width="159" height="89" /></p> <hr /> <p style="text-align: center;"><span style="font-size: 18px; color: #973e97;"><strong>Controlling ADC Process Through In-Depth Knowledge of Process Analytical Technologies</strong></span></p> <hr /> <p><span style="color: #973e97;"><strong>1.30 pm</strong></span> <strong>Risk Evaluation of Nitrosamine Impurities in Drug-Linker Intermediates Used to Generate ADCs</strong></p> <p>• Providing a science-based, holistic approach to evaluating the risks of nitrosamine presence in drug-linker as intermediates towards ADC drug substances<br /> • Demonstrating that chemically synthesised fragments of ADCs are<br /> unlikely to lead to nitrosamine presence in the final drug product<br /> • Proposing a simplified abbreviated workflow for quality risk management of nitrosamines in drug-linkers</p> <p><strong><span style="color: #973e97;">Osama Chahrour</span></strong><span style="color: #973e97;">, Principal Scientist, </span><span style="color: #973e97;">Chemical Development, </span><strong><span style="color: #973e97;">AstraZeneca</span></strong></p> <hr /> <p><span style="color: #973e97;"><strong>2.00 pm</strong></span> <strong>Roundtable Discusson: Brainstorming Novel Conjugation </strong><strong>Methods to Improve ADC Product Quality & Yield</strong></p> <p>• Discussing the challenges in achieving desired product quality and yield in ADC synthesis and conjugation<br /> • Exploring the benefits of site-specific conjugation technologies in ADC process optimisation– what has been demonstrated to simplify process testing so far?<br /> • Debating the top considerations from ADC process development impacting process robustness and product quality control</p> </div> </div> <div class="fl-tabs-panel"> <div class="fl-tabs-label fl-tabs-panel-label" data-index="4" tabindex="0"> <span><span style="font-size: 18px; color: #656568;"><strong>Manufacturing & Supply Chain</strong></span></span> <i class="fas fa-plus"></i> </div> <div class="fl-tabs-panel-content fl-clearfix" id="fl-tabs-ubx5fyle9dz3-panel-4" data-index="4" aria-hidden="true" aria-labelledby="fl-tabs-ubx5fyle9dz3-label-4" role="tabpanel" aria-live="polite"> <p style="text-align: center;"><span style="font-size: 18px; color: #656568;"><strong>Manufacturing & Supply Chain</strong></span></p> <p style="text-align: center;"><strong>Chair: <em>Ying Buechler</em></strong><em>, Chief </em><em>Technology Officer,</em><strong><em> Ambrx, a Johnson & Johnson Company</em></strong></p> <p style="text-align: center;"><span style="color: #a91970;"><a style="color: #a91970;" href="https://worldadc-europe.com/whats-on/full-event-guide/"><em>Download the Full Event Guide for full details</em></a></span></p> <hr /> <p style="text-align: center;"><span style="font-size: 18px; color: #656568;"><strong>Maintaining & Upgrading ADC Manufacturing Under Accelerated Clinical Timelines</strong></span></p> <hr /> <p><span style="color: #656568;"><strong>11.00 am</strong></span> <strong>Managing CMC Challenges & Capabilities Across Complex ADC Supply Chain</strong></p> <p>• Evaluating challenges and opportunities in ADC development and CMC<br /> • Exploring CMC strategy across ADC components: drug-linker, mAbs, DS and DP<br /> • Highlighting strategies for effective ADC manufacturing supply chain</p> <p><span style="color: #656568;"><strong>Francois D’Hooge</strong>, Senior Manager, CMC Management,<strong> Daiichi Sankyo<br /> Meike Roskamp</strong>, Director, Bioconjugation, <strong>Daiichi Sankyo</strong></span></p> <hr /> <p><strong><span style="color: #656568;">11.30 am</span> Roundtable Discussion: Assessing Bottlenecks & Opportunities to Streamline ADC Clinical Supply Under Accelerated Manufacturing Timelines</strong></p> <p>• Assessing rate-limiting hurdles in ADC development and manufacturing under accelerated IND and BLA submission timelines<br /> • Utilising real-time experimental data to take on calculated risk and parallel development<br /> • Optimising end-to-end internal alignment to ensure ADC supply chain efficiency</p> <hr /> <p><span style="color: #973e97;"><strong><span style="color: #656568;">12.00 pm</span><span style="color: #973e97;"> </span><span style="color: #000000;">Session Presented by</span><br /> </strong></span></p> <p><img loading="lazy" decoding="async" class="aligncenter" src="https://www.cambridgesciencepark.co.uk/media/uploads/files/veranova-logo-tm_rgb.jpg" alt="Spotlight - Veranova" width="242" height="50" /></p> <hr /> <p><span style="color: #f9af1f;"><strong>12.30 pm Lunch & Learn Sessions Presented by </strong></span></p> <p><img decoding="async" class="aligncenter" src="https://encrypted-tbn0.gstatic.com/images?q=tbn:ANd9GcTyLOffT9OU0YkN_J_HK_HnW3Dfwajxjb6gpQ&s" alt="Merck KGaA Logo Purple transparent PNG - StickPNG" width="159" height="89" /></p> <hr /> <p style="text-align: center;"><span style="font-size: 18px; color: #656568;"><strong>Exploring ADC Best Practices & Strategy for Safe Manufacturing at Scale</strong></span></p> <hr /> <p><strong><span style="color: #656568;">1.30 pm</span> Integrating Highly Potent Drug Safety Into ADC Development & Manufacturing</strong></p> <p>• Integrating HPAPI Occupational Health and Safety within ADC manufacturing projects – getting the strategic decisions right<br /> • Exploring ADC component hazard assessments (occupational toxicology) and risk assessments across targeting moieties and payloads<br /> • Covering API Containment and Control in all ADC working environments</p> <p><span style="color: #656568;"><strong>Justin Mason-Home</strong>, Director,<strong> HPAPI Project Services Limited</strong></span></p> <hr /> <p><strong><span style="color: #656568;">2.00 pm <span style="color: #000000;">Roundtable Discussion: Breaking Down the Top Opportunities to Overcome ADC Manufacturing & Supply Chain Bottlenecks</span></span></strong></p> <p>Join this closing roundtable session with leaders in ADC CMC field to break down the key learnings from the two days presentations and discussion. With your fellow speakers and attendees, discuss,<br /> debate and evaluate the opportunities and challenges in ADC manufacturing timelines, navigating supply with multiple outsourcing partners, technology transfer and scale-up, and more.</p> </div> </div> </div> </div> </div> </div> <div class="fl-module fl-module-ee-agenda fl-node-ige1ahrjvkoq" data-node="ige1ahrjvkoq"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 3:00 pm </span> Afternoon Break & Networking </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> <center><span style="font-size: 20px;"><span style="color: #990582;">Leveraging Biomarkers & Diagnostic Tools to Inform Patient Selection Strategies for Precision Medicine ADC Development</span></center> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 3:30 pm </span> Targeted Cancer Therapy for Patients With 17p Deletion </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23961" class="view-speaker" speaker-id="23961"><span>Andreas Pahl</span></a></em> Chief Executive Officer, Heidelberg Pharma </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• Breaking down clinical profile and new phase II escalation data of HDP-101 targeting BCMA in myeloma patients</p> <p>• Laying out retrospective analysis and investigation in deletion models of 17p deletion as a biomarker and patient selection tool for amanitin payload ADCs</p> <p>• Discussing future directions for clinical development and potential for patient selection investigation for precision medicine ADC development</p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 4:00 pm </span> Panel Discussion: Evaluating the Need for Biomarker & Patient Selection Tools in an Increasingly Busy ADC Field: What are the Predictions for Future ADC Precision Medicine Approaches? </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23962" class="view-speaker" speaker-id="23962"><span>Rakesh Dixit</span></a></em> President & Chief Executive Officer, Bionavigen Oncology </li> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23963" class="view-speaker" speaker-id="23963"><span>Sharsti Sandall</span></a></em> Senior Director, Research, ADC Programs, Pfizer </li> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23964" class="view-speaker" speaker-id="23964"><span>Heidi Wang</span></a></em> Chief Executive Officer, OBI Pharma </li> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23873" class="view-speaker" speaker-id="23873"><span>Joseph Woolery</span></a></em> Vice President, Clinical Development, Zymeworks </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p>• What is the current need and appetite for ADC biomarker development and patient selection strategies heading into 2025?</p> <p>• Discussing the different methodologies across machine learning and digital pathology to quantify IHC derived ADC target expression</p> <p>• Addressing the challenges and opportunities of biomarker analysis to select patient populations to benefit from specific ADCs</p> <p>• Summarising future predictions for precision medicine ADC development</p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 4:30 pm </span> Chair’s Closing Remarks </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://worldadc-europe.com/speakers/#speaker23871" class="view-speaker" speaker-id="23871"><span>Robert Lutz</span></a></em> Chief Scientific Officer, Iksuda Therapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 4:30 pm </span> End of Scientific Programme Day Two </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> </div> </div> </div> </div> </div> </div> <div class="fl-col-group fl-node-x9sou2r6efyl" data-node="x9sou2r6efyl"> <div class="fl-col fl-node-pw4bdoc6fq9n fl-col-bg-color" data-node="pw4bdoc6fq9n"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-button fl-node-elqh0mbzjy1f" data-node="elqh0mbzjy1f"> <div class="fl-module-content fl-node-content"> <div class="fl-button-wrap fl-button-width-custom fl-button-left fl-button-has-icon"> <a href="https://worldadc-europe.com/whats-on/full-event-guide/" target="_self" class="fl-button fl-button-icon-animation"> <span 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content.css('background-image','url('+imageSrc[screenSize]+')');row.data('current-image-loaded',screenSize);},_scrollParallaxBackgrounds:function(){$('.fl-row-bg-parallax').each(FLBuilderLayout._scrollParallaxBackground);},_scrollParallaxBackground:function(){var win=$(window),row=$(this),content=row.find('> .fl-row-content-wrap'),speed=row.data('parallax-speed'),offset=content.offset(),yPos=-((win.scrollTop()-offset.top)/ speed),initialOffset=(row.data('parallax-offset')!=null)?row.data('parallax-offset'):0,totalOffset=yPos-initialOffset;content.css('background-position','center '+totalOffset+'px');},_initBgVideos:function(){$('.fl-bg-video').each(FLBuilderLayout._initBgVideo);},_initBgVideo:function(){var wrap=$(this),width=wrap.data('width'),height=wrap.data('height'),mp4=wrap.data('mp4'),youtube=wrap.data('youtube'),vimeo=wrap.data('vimeo'),mp4Type=wrap.data('mp4-type'),webm=wrap.data('webm'),webmType=wrap.data('webm-type'),fallback=wrap.data('fallback'),loaded=wrap.data('loaded'),videoMobile=wrap.data('video-mobile'),fallbackTag='',videoTag=null,mp4Tag=null,webmTag=null;if(loaded){return;} videoTag=$('<video autoplay loop muted playsinline></video>');if('undefined'!=typeof fallback&&''!=fallback){videoTag.attr('poster','data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7') videoTag.css({backgroundImage:'url("'+fallback+'")',backgroundColor:'transparent',backgroundRepeat:'no-repeat',backgroundSize:'cover',backgroundPosition:'center center',})} if('undefined'!=typeof mp4&&''!=mp4){mp4Tag=$('<source />');mp4Tag.attr('src',mp4);mp4Tag.attr('type',mp4Type);videoTag.append(mp4Tag);} if('undefined'!=typeof webm&&''!=webm){webmTag=$('<source 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Vimeo!=='undefined'&&videoId){player=new Vimeo.Player(videoPlayer[0],{id:videoId,loop:true,title:false,portrait:false,background:true,autopause:false,muted:true});playerWrap.data('VMPlayer',player);if("no"===enableAudio){player.setVolume(0);} else if("yes"===enableAudio){if(ua.indexOf("Safari")>-1||ua.indexOf("Chrome")>-1||ua.indexOf("Firefox")>-1){player.setVolume(0);audioButton.show();} else{player.setVolume(1);}} player.play().catch(function(error){FLBuilderLayout._onErrorYoutubeVimeo(playerWrap)});if(audioButton.length>0){audioButton.on('click',{button:audioButton,player:player},FLBuilderLayout._toggleBgVideoAudio);}}},_toggleBgVideoAudio:function(e){var player=e.data.player,control=e.data.button.find('.fl-audio-control');if(control.hasClass('fa-volume-off')){control.removeClass('fa-volume-off').addClass('fa-volume-up');e.data.button.find('.fa-times').hide();if('function'===typeof player.unMute){player.unMute();} else{player.setVolume(1);}} else{control.removeClass('fa-volume-up').addClass('fa-volume-off');e.data.button.find('.fa-times').show();if('function'===typeof player.unMute){player.mute();} else{player.setVolume(0);}}},_videoBgSourceError:function(e){var source=$(e.target),wrap=source.closest('.fl-bg-video'),vid=wrap.find('video'),fallback=wrap.data('fallback'),fallbackTag='';source.remove();if(vid.find('source').length){return;}else if(''!==fallback){fallbackTag=$('<div></div>');fallbackTag.addClass('fl-bg-video-fallback');fallbackTag.css('background-image','url('+fallback+')');wrap.append(fallbackTag);vid.remove();}},_resizeBgVideos:function(){$('.fl-bg-video').each(function(){FLBuilderLayout._resizeBgVideo.apply(this);if($(this).parent().find('img').length>0){$(this).parent().imagesLoaded($.proxy(FLBuilderLayout._resizeBgVideo,this));}});},_resizeBgVideo:function(){if(0===$(this).find('video').length&&0===$(this).find('iframe').length){return;} var 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if(iframe.length){if(typeof wrap.data('youtube')!=='undefined'){FLBuilderLayout._resizeYoutubeBgVideo.apply(this);}}},_resizeOnLoadedMeta:function(){var video=$(this),wrapHeight=video.parent().outerHeight(),wrapWidth=video.parent().outerWidth(),vidWidth=video[0].videoWidth,vidHeight=video[0].videoHeight,newHeight=Math.round(vidHeight*wrapWidth/vidWidth),newWidth=wrapWidth,newLeft=0,newTop=0;if(newHeight<wrapHeight){newHeight=wrapHeight;newWidth=Math.round(vidWidth*wrapHeight/vidHeight);newLeft=-((newWidth-wrapWidth)/2);} else{newTop=-((newHeight-wrapHeight)/2);} video.parent().data('width',vidWidth);video.parent().data('height',vidHeight);video.css({'left':newLeft+'px','top':newTop+'px','width':newWidth+'px','height':newHeight+'px'});},_resizeYoutubeBgVideo:function(){var 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node.waypoint({offset:offset,handler:FLBuilderLayout._doModuleAnimation});});}},_doModuleAnimation:function(){var module='undefined'==typeof this.element?$(this):$(this.element),delay=parseFloat(module.data('animation-delay')),duration=parseFloat(module.data('animation-duration'));if(!isNaN(duration)){module.css('animation-duration',duration+'s');} if(!isNaN(delay)&&delay>0){setTimeout(function(){module.addClass('fl-animated');},delay*1000);}else{setTimeout(function(){module.addClass('fl-animated');},1);}},_initHash:function(){var hash=window.location.hash.replace('#','').split('/').shift(),element=null,tabs=null,responsiveLabel=null,tabIndex=null,label=null;if(''!==hash){try{element=$('#'+hash);if(element.length>0){if(element.hasClass('fl-accordion-item')){setTimeout(function(){element.find('.fl-accordion-button').trigger('click');},100);} 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element=$('#'+id);if(element.length>0){flNode=element.hasClass('fl-row')||element.hasClass('fl-col')||element.hasClass('fl-module');if(!element.hasClass('fl-no-scroll')&&(link.hasClass('fl-scroll-link')||flNode)){$(link).on('click',FLBuilderLayout._scrollToElementOnLinkClick);} if(element.hasClass('fl-accordion-item')){$(link).on('click',FLBuilderLayout._scrollToAccordionOnLinkClick);} if(element.hasClass('fl-tabs-panel')){$(link).on('click',FLBuilderLayout._scrollToTabOnLinkClick);}}} catch(e){}}}},_scrollToElementOnLinkClick:function(e,callback){var element=$('#'+$(this).attr('href').split('#').pop());FLBuilderLayout._scrollToElement(element,callback);e.preventDefault();},_scrollToElement:function(element,callback){var config=FLBuilderLayoutConfig.anchorLinkAnimations,dest=0,win=$(window),doc=$(document);if(element.length>0){if('fixed'===element.css('position')||'fixed'===element.parent().css('position')){dest=element.position().top;} else 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element=$('#'+$(this).attr('href').split('#').pop()),tabs=null,label=null,responsiveLabel=null;if(element.length>0){tabs=element.closest('.fl-tabs');responsiveLabel=element.find('.fl-tabs-panel-label');tabIndex=responsiveLabel.data('index');label=tabs.find('.fl-tabs-labels .fl-tabs-label[data-index='+tabIndex+']');if(responsiveLabel.is(':visible')){var callback=function(){if(element){responsiveLabel.trigger($.Event('click',{which:1}));}};FLBuilderLayout._scrollToElementOnLinkClick.call(this,e,callback);} else{label[0].click();FLBuilderLayout._scrollToElement(element);} e.preventDefault();}},_initForms:function(){if(!FLBuilderLayout._hasPlaceholderSupport){$('.fl-form-field input').each(FLBuilderLayout._initFormFieldPlaceholderFallback);} $('.fl-form-field input').on('focus',FLBuilderLayout._clearFormFieldError);},_hasPlaceholderSupport:function(){var input=document.createElement('input');return'undefined'!=input.placeholder;},_initFormFieldPlaceholderFallback:function(){var 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.fl-tabs-label').on('keypress',$.proxy(this._responsiveLabelClick,this));win.on('resize',$.proxy(this._setupTabs,this));if($(this.nodeClass+' .fl-tabs-vertical').length>0){this._resize();win.off('resize'+this.nodeClass);win.on('resize'+this.nodeClass,$.proxy(this._resize,this));} FLBuilderLayout.preloadAudio(this.nodeClass+' .fl-tabs-panel-content');this._setupTabs();},_labelClick:function(e){var label=$(e.target).closest('.fl-tabs-label'),index=label.data('index'),wrap=label.closest('.fl-tabs'),allIcons=wrap.find('.fl-tabs-panels .fl-tabs-label .fas'),icon=wrap.find('.fl-tabs-panels .fl-tabs-label[data-index="'+index+'"] .fas');if(!this._validClick(e)){return;} allIcons.addClass('fa-plus');icon.removeClass('fa-plus');wrap.find('.fl-tabs-labels:first > .fl-tab-active').removeClass('fl-tab-active').attr('aria-selected','false').attr('aria-expanded','false');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > .fl-tab-active').removeClass('fl-tab-active');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > .fl-tabs-panel-content').attr('aria-hidden','true').css('display','');wrap.find('.fl-tabs-labels:first > .fl-tabs-label[data-index="'+index+'"]').addClass('fl-tab-active').attr('aria-selected','true').attr('aria-expanded','true');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > .fl-tabs-panel-label[data-index="'+index+'"]').addClass('fl-tab-active');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > 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.fas'),icon=label.find('.fas');if(!this._validClick(e)){return;} if(label.hasClass('fl-tab-active')||wrap.hasClass('fl-tabs-animation')){return;} allIcons.addClass('fa-plus');icon.removeClass('fa-plus');wrap.addClass('fl-tabs-animation');activeContent.slideUp('normal');content.slideDown('normal',function(){wrap.find('.fl-tab-active').removeClass('fl-tab-active').attr('aria-hidden','true');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > .fl-tabs-panel-content').attr('aria-hidden','true');wrap.find('.fl-tabs-label[data-index="'+index+'"]').addClass('fl-tab-active').attr('aria-hidden','false');wrap.find('.fl-tabs-panels:first > .fl-tabs-panel > .fl-tabs-panel-content[data-index="'+index+'"]').attr('aria-hidden','false');content.addClass('fl-tab-active');wrap.removeClass('fl-tabs-animation');FLBuilderLayout.refreshGalleries(content);FLBuilderLayout.refreshGridLayout(content);FLBuilderLayout.reloadSlider(content);FLBuilderLayout.resizeAudio(content);FLBuilderLayout.reloadGoogleMap(wrap.find('.fl-tabs-panel-content[data-index="'+index+'"]'));if(label.offset().top<$(window).scrollTop()+100){$('html, body').animate({scrollTop:label.offset().top-100},500,'swing');}});},_resize:function(){$(this.nodeClass+' .fl-tabs-vertical').each($.proxy(this._resizeVertical,this));},_resizeVertical:function(e){var wrap=$(this.nodeClass+' .fl-tabs-vertical'),labels=wrap.find('.fl-tabs-labels'),panels=wrap.find('.fl-tabs-panels');panels.css('min-height',labels.height()+'px');},_validClick:function(e){return(e.which==1||e.which==13||e.which==32)?true:false;},_setupTabs:function(){index=this.activeTab-1;if(index<0){index=0;} var winWidth=$(window).width(),activeTabContent=$(this.nodeClass+' .fl-tabs-panel-content.fl-tab-active'),activeTabPanel=activeTabContent.parent(),activeTabLabelIcon=activeTabPanel.find('i'),smallBreakPoint=FLBuilderLayoutConfig.breakpoints.small,mediumBreakPoint=FLBuilderLayoutConfig.breakpoints.medium;if(winWidth<=smallBreakPoint&&'close-all'==this.tabsOnMobile){activeTabContent.hide();activeTabLabelIcon.addClass('fa-plus');activeTabPanel.find('.fl-tab-active').removeClass('fl-tab-active').attr('aria-hidden','true');}else if(winWidth>=smallBreakPoint){activeTabContent.show();activeTabLabelIcon.removeClass('fa-plus');}},};})(jQuery);;(function($){$(function(){new FLBuilderTabs({id:'ubx5fyle9dz3',tabsOnMobile:'open-active',activeTab:'1',});});})(jQuery);;(function($){FLBuilderMenu=function(settings){this.nodeId=settings.id;this.nodeClass='.fl-node-'+settings.id;this.wrapperClass=this.nodeClass+' .fl-menu';this.type=settings.type;this.mobileToggle=settings.mobile;this.mobileBelowRow=settings.mobileBelowRow;this.mobileFlyout=settings.mobileFlyout;this.breakPoints=settings.breakPoints;this.mobileBreakpoint=settings.mobileBreakpoint;this.currentBrowserWidth=$(window).width();this.postId=settings.postId;this.mobileStacked=settings.mobileStacked;this._initMenu();$(window).on('resize',$.proxy(function(e){var width=$(window).width();if(width!=this.currentBrowserWidth){this.currentBrowserWidth=width;this._initMenu();this._clickOrHover();} this._resizeFlyoutMenuPanel();},this));$(window).on('scroll',$.proxy(function(e){this._resizeFlyoutMenuPanel();},this));$('body').on('click',$.proxy(function(e){if('undefined'!==typeof FLBuilderConfig){return;} var activeMobileMenu=$(this.wrapperClass+' .fl-menu-mobile-toggle.fl-active');if(activeMobileMenu.length&&('expanded'!==this.mobileToggle)){$(activeMobileMenu).trigger('click');} $(this.wrapperClass).find('.fl-has-submenu').removeClass('focus');$(this.wrapperClass).find('.fl-has-submenu .sub-menu').removeClass('focus');},this));$(this.wrapperClass+' ul.menu > li:last-child').on('focusout',$.proxy(function(e){if($(this.wrapperClass).find('.fl-menu-mobile-toggle').hasClass('fl-active')&&('expanded'!==this.mobileToggle)){if(!$(e.relatedTarget).parent().hasClass('menu-item')){$(this.wrapperClass).find('.fl-menu-mobile-toggle').trigger('click');}}},this));};FLBuilderMenu.prototype={nodeClass:'',wrapperClass:'',type:'',breakPoints:{},$submenus:null,_isMobile:function(){return this.currentBrowserWidth<=this.breakPoints.small?true:false;},_isMedium:function(){return this.currentBrowserWidth<=this.breakPoints.medium?true:false;},_isLarge:function(){return this.currentBrowserWidth<=this.breakPoints.large?true:false;},_isMenuToggle:function(){if(('always'==this.mobileBreakpoint||(this._isMobile()&&'mobile'==this.mobileBreakpoint)||(this._isMedium()&&'medium-mobile'==this.mobileBreakpoint)||(this._isLarge()&&'large-mobile'==this.mobileBreakpoint))&&($(this.wrapperClass).find('.fl-menu-mobile-toggle').is(':visible')||'expanded'==this.mobileToggle)){return true;} return false;},_initMenu:function(){this._setupSubmenu();this._menuOnFocus();this._menuOnEscape();this._submenuOnClick();if($(this.nodeClass).length&&this.type=='horizontal'){this._initMegaMenus();} if(this._isMenuToggle()||this.type=='accordion'){$(this.wrapperClass).off('mouseenter mouseleave');this._menuOnClick();this._clickOrHover();}else{$(this.wrapperClass).off('click');this._submenuOnRight();this._submenuRowZindexFix();} if(this.mobileToggle!='expanded'){this._toggleForMobile();} if($(this.wrapperClass).find('.fl-menu-search-item').length){this._toggleMenuSearch();} if($(this.wrapperClass).find('.fl-menu-cart-item').length){this._wooUpdateParams();}},_setupSubmenu:function(){$(this.wrapperClass+' ul.sub-menu').each(function(){$(this).closest('li').attr('aria-haspopup','true');});},_menuOnFocus:function(){var cKey=0,isShifted=false;$(this.nodeClass).off('keydown').on('keydown','a',function(e){cKey=e.which;isShifted=e.shiftKey;});$(this.nodeClass).off('focus').on('focus','a',$.proxy(function(e){var $menuItem=$(e.target).parents('.menu-item').first(),$parents=$(e.target).parentsUntil(this.wrapperClass);$('.fl-menu .focus').removeClass('focus');$parents.addClass('focus') if(!$menuItem.closest('.fl-has-submenu').hasClass('escaped')){$menuItem.addClass('focus')} else{$menuItem.closest('.fl-has-submenu').removeClass('focus escaped')}},this)).on('focusout','a',$.proxy(function(e){var el=$(e.target).parent(),$megaMenu=el.closest('.mega-menu'),$megaLastItem=$megaMenu.find('> .sub-menu > .menu-item:last-child'),$lastItem=el.parents('.fl-has-submenu:last').find('.menu-item:last'),isLastChild=!$megaMenu.length&&el.is($lastItem);if($megaMenu.length){isLastChild=el.is($megaLastItem)||el.is($megaLastItem.find('.menu-item:last-child'));} if(isLastChild&&cKey===9&&isShifted){isLastChild=false;cKey=0;isShifted=false;} else if(cKey===27){isLastChild=false;} if(isLastChild){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_menuOnEscape:function(){$('body').off('keydown').on('keydown',$.proxy(function(e){if(e.which!==27){return;} if($(e.target).closest('.menu-item').length){var activeSubmenu=null,menuItem=$(e.target).closest('.menu-item'),type=menuItem.closest('.fl-menu-accordion').length?'accordion':'horizontal';if('horizontal'===type){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('focus')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.parent().addClass('escaped');activeSubmenu.parent().find('a:first').focus();} else{if(menuItem.hasClass('fl-has-submenu')&&'accordion'===type&&menuItem.hasClass('fl-active')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.slideUp(400,function(){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('fl-active')){activeSubmenu.parent().last().find('a:first').focus();} else{menuItem.removeClass('focus');menuItem.parents('.menu-item').first().find('a:first').focus();} activeSubmenu.parent().last().removeClass('fl-active');});}} else{$('.fl-menu').find('li.menu-item.focus').last().removeClass('focus');}},this));},_menuOnClick:function(){$(this.wrapperClass).off().on('click','.fl-has-submenu-container',$.proxy(function(e){var $link=$(e.target).parents('.fl-has-submenu').first(),$subMenu=$link.children('.sub-menu').first(),$href=$link.children('.fl-has-submenu-container').first().find('> a').attr('href'),$subMenuParents=$(e.target).parents('.sub-menu'),$activeParents=$(e.target).parents('.fl-has-submenu.fl-active');if(!$subMenu.is(':visible')||$(e.target).hasClass('fl-menu-toggle')||($subMenu.is(':visible')&&(typeof $href==='undefined'||$href=='#'))){e.preventDefault();} else{e.stopPropagation();window.location.href=$href;return;} if($(this.wrapperClass).hasClass('fl-menu-accordion-collapse')){if(!$link.parents('.menu-item').hasClass('fl-active')){$('.menu .fl-active',this.wrapperClass).not($link).removeClass('fl-active');} else if($link.parents('.menu-item').hasClass('fl-active')&&$link.parent('.sub-menu').length){$('.menu .fl-active',this.wrapperClass).not($link).not($activeParents).removeClass('fl-active');} $('.sub-menu',this.wrapperClass).not($subMenu).not($subMenuParents).slideUp('normal');} if(!this.mobileStacked&&'horizontal'==this.type&&'expanded'==this.mobileToggle){$(this.wrapperClass).find('.fl-active').not($link).not($activeParents).removeClass('fl-active');} else{$subMenu.slideToggle();} $link.toggleClass('fl-active');e.stopPropagation();},this));},_submenuOnClick:function(){$(this.wrapperClass+' .sub-menu').off().on('click','a',$.proxy(function(e){if($(e.target).parent().hasClass('focus')){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_clickOrHover:function(){this.$submenus=this.$submenus||$(this.wrapperClass).find('.sub-menu');var $wrapper=$(this.wrapperClass),$menu=$wrapper.find('.menu');$li=$wrapper.find('.fl-has-submenu');if(this._isMenuToggle()){$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').fadeOut();}});}else{$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').css({'display':'','opacity':''});}});}},_submenuOnRight:function(){$(this.wrapperClass).on('mouseenter focus','.fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} var $link=$(e.currentTarget),$parent=$link.parent(),$subMenu=$link.find('.sub-menu'),subMenuWidth=$subMenu.width(),subMenuPos=0,bodyWidth=$('body').width();if($link.closest('.fl-menu-submenu-right').length!==0){$link.addClass('fl-menu-submenu-right');}else if($('body').hasClass('rtl')){subMenuPos=$parent.is('.sub-menu')?$parent.offset().left-subMenuWidth:$link.offset().left-$link.width()-subMenuWidth;if(subMenuPos<=0){$link.addClass('fl-menu-submenu-right');}}else{subMenuPos=$parent.is('.sub-menu')?$parent.offset().left+$parent.width()+subMenuWidth:$link.offset().left+$link.width()+subMenuWidth;if(subMenuPos>bodyWidth){$link.addClass('fl-menu-submenu-right');}}},this)).on('mouseleave','.fl-has-submenu',$.proxy(function(e){$(e.currentTarget).removeClass('fl-menu-submenu-right');},this));},_submenuRowZindexFix:function(e){$(this.wrapperClass).on('mouseenter','ul.menu > .fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} $(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','10');},this)).on('mouseleave','ul.menu > .fl-has-submenu',$.proxy(function(e){$(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','');},this));},_toggleForMobile:function(){var $wrapper=null,$menu=null,self=this;if(this._isMenuToggle()){if(this._isMobileBelowRowEnabled()){this._placeMobileMenuBelowRow();$wrapper=$(this.wrapperClass);$menu=$(this.nodeClass+'-clone');$menu.find('ul.menu').show();} else{$wrapper=$(this.wrapperClass);$menu=$wrapper.find('.menu');} if(!$wrapper.find('.fl-menu-mobile-toggle').hasClass('fl-active')&&!self.mobileFlyout){$menu.css({display:'none'});} if(self.mobileFlyout){this._initFlyoutMenu();} $wrapper.on('click','.fl-menu-mobile-toggle',function(e){$(this).toggleClass('fl-active');if(self.mobileFlyout){self._toggleFlyoutMenu();} else{var targetMenu=null;if(self.mobileBelowRow){targetMenu=$(this).closest('.fl-col').next('.fl-menu-mobile-clone');}else{targetMenu=$(this).closest('.fl-menu').find('ul.menu');} if(targetMenu.length){$menu=$(targetMenu);} $menu.slideToggle();} e.stopPropagation();});$menu.off().on('click','.menu-item > a[href*="#"]:not([href="#"])',function(e){var $href=$(this).attr('href'),$targetID=$href.split('#')[1],element=$('#'+$targetID);if($('body').find(element).length>0){$(this).toggleClass('fl-active');FLBuilderLayout._scrollToElement(element);if(!self._isMenuToggle()){$menu.slideToggle();}}});} else{if(this._isMobileBelowRowEnabled()){this._removeMenuFromBelowRow();} $wrapper=$(this.wrapperClass),$menu=$wrapper.find('ul.menu');$wrapper.find('.fl-menu-mobile-toggle').removeClass('fl-active');$menu.css({display:''});if(!this._isMobileBelowRowEnabled()){$menu.off('click','.menu-item > a[href*="#"]:not([href="#"])');} if(this.mobileFlyout&&$wrapper.find('.fl-menu-mobile-flyout').length>0){$('body').css('margin','');$('.fl-builder-ui-pinned-content-transform').css('transform','');$menu.unwrap();$wrapper.find('.fl-menu-mobile-close').remove();$wrapper.find('.fl-menu-mobile-opacity').remove();}}},_initMegaMenus:function(){var module=$(this.nodeClass),rowContent=module.closest('.fl-row-content'),rowWidth=rowContent.width(),megas=module.find('.mega-menu'),disabled=module.find('.mega-menu-disabled'),isToggle=this._isMenuToggle();if(isToggle){megas.removeClass('mega-menu').addClass('mega-menu-disabled');module.find('li.mega-menu-disabled > ul.sub-menu').css('width','');rowContent.css('position','');}else{disabled.removeClass('mega-menu-disabled').addClass('mega-menu');module.find('li.mega-menu > ul.sub-menu').css('width',rowWidth+'px');rowContent.css('position','relative');}},_isMobileBelowRowEnabled:function(){return this.mobileBelowRow&&$(this.nodeClass).closest('.fl-col').length;},_placeMobileMenuBelowRow:function(){if($(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=null,col=module.closest('.fl-col');if(module.length<1){return;} clone=(module.length>1)?$(module[0]).clone():module.clone();module.find('ul.menu').remove();clone.addClass((this.nodeClass+'-clone').replace('.',''));clone.addClass('fl-menu-mobile-clone');clone.find('.fl-menu-mobile-toggle').remove();col.after(clone);if(module.hasClass('fl-animation')){clone.removeClass('fl-animation');} this._menuOnClick();},_removeMenuFromBelowRow:function(){if(!$(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=$(this.nodeClass+'-clone'),menu=clone.find('ul.menu');module.find('.fl-menu-mobile-toggle').after(menu);clone.remove();menu.find('a').each(FLBuilderLayout._initAnchorLink);},_initFlyoutMenu:function(){var win=$(window),wrapper=$(this.wrapperClass),menu=wrapper.find('ul.menu'),button=wrapper.find('.fl-menu-mobile-toggle');if(0===wrapper.find('.fl-menu-mobile-flyout').length){menu.wrap('<div class="fl-menu-mobile-flyout"></div>');} if(0===wrapper.find('.fl-menu-mobile-close').length){close=window.fl_responsive_close||'Close' wrapper.find('.fl-menu-mobile-flyout').prepend('<button class="fl-menu-mobile-close" aria-label="'+close+'"><i class="fas fa-times" aria-hidden="true"></i></button>');} if(wrapper.hasClass('fl-menu-responsive-flyout-push-opacity')&&0===wrapper.find('.fl-menu-mobile-opacity').length){wrapper.append('<div class="fl-menu-mobile-opacity"></div>');} wrapper.on('click','.fl-menu-mobile-opacity, .fl-menu-mobile-close',function(e){button.trigger('click');e.stopPropagation();});if('undefined'!==typeof FLBuilder){FLBuilder.addHook('restartEditingSession',function(){$('.fl-builder-ui-pinned-content-transform').css('transform','');if(button.hasClass('fl-active')){button.trigger('click');}});}},_toggleFlyoutMenu:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),position=wrapper.hasClass('fl-flyout-right')?'right':'left',pushMenu=wrapper.hasClass('fl-menu-responsive-flyout-push')||wrapper.hasClass('fl-menu-responsive-flyout-push-opacity'),opacity=wrapper.find('.fl-menu-mobile-opacity'),marginPos={},posAttr={},fixedPos={},winHeight=$(window).height(),fixedHeader=$('header, header > div');this._resizeFlyoutMenuPanel();if($('.fl-builder-ui-pinned-content-transform').length>0&&!$('body').hasClass('fl-builder-edit')){$('.fl-builder-ui-pinned-content-transform').css('transform','none');} if(pushMenu){marginPos['margin-'+position]=button.hasClass('fl-active')?'250px':'0px';$('body').animate(marginPos,200);if(fixedHeader.length>0){fixedPos[position]=button.hasClass('fl-active')?'250px':'0px';fixedHeader.each(function(){if('fixed'==$(this).css('position')){$(this).css({'-webkit-transition':'none','-o-transition':'none','transition':'none'});$(this).animate(fixedPos,200);}});}} if(opacity.length>0&&button.hasClass('fl-active')){opacity.show();} else{opacity.hide();}},_resizeFlyoutMenuPanel:function(){const wrapper=$(this.wrapperClass);const wrapFlyout=wrapper.find('.fl-menu-mobile-flyout');if(wrapFlyout.length>0){wrapFlyout.css(this._getFlyoutMenuPanelPosition());}},_getFlyoutMenuPanelPosition:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),side=wrapper.hasClass('fl-flyout-right')?'right':'left',winHeight=$(window).outerHeight(),winTop=$(window).scrollTop(),adminBarHeight=$('#wpadminbar').length?$('#wpadminbar').height():0,flyoutPosition={};flyoutPosition[side]='-267px';if(!button.hasClass('fl-active')){return flyoutPosition;} flyoutPosition[side]='0px';flyoutPosition['height']=winHeight+'px';flyoutPosition['top']='0px';if(adminBarHeight>0){const diff=adminBarHeight-winTop;flyoutPosition['top']=diff<=0?'0px':(diff)+'px';} return flyoutPosition;},_toggleMenuSearch:function(){var wrapper=$(this.wrapperClass).find('.fl-menu-search-item'),button=wrapper.find('a.fl-button'),form=wrapper.find('.fl-search-form-input-wrap'),self=this;button.on('click',function(e){e.preventDefault();if(form.is(':visible')){form.stop().fadeOut(200);} else{form.stop().fadeIn(200);$('body').on('click.fl-menu-search',$.proxy(self._hideMenuSearch,self));form.find('.fl-search-text').focus();}});},_hideMenuSearch:function(e){var form=$(this.wrapperClass).find('.fl-search-form-input-wrap');if(e!==undefined){if($(e.target).closest('.fl-menu-search-item').length>0){return;}} form.stop().fadeOut(200);$('body').off('click.fl-menu-search');},_wooUpdateParams:function(){if('undefined'!==typeof wc_cart_fragments_params){wc_cart_fragments_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;} if('undefined'!==typeof wc_add_to_cart_params){wc_add_to_cart_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;}},};})(jQuery);;(function($){$(function(){new FLBuilderMenu({id:'5ba0ab906f568',type:'horizontal',mobile:'text',mobileBelowRow:true,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'medium-mobile',postId:'198',mobileStacked:true,});});})(jQuery);;jQuery(function($){$(function(){$('.fl-node-5ba0ae36c560f .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;jQuery(function($){$(function(){$('.fl-node-5df7a79c323db .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;(function($){$(function(){new FLBuilderMenu({id:'5df7a7db5b61b',type:'accordion',mobile:'hamburger',mobileBelowRow:false,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'always',postId:'198',mobileStacked:true,});});})(jQuery);;;var FLBuilderCountdown;var FLBuilderCountdownIntervals=FLBuilderCountdownIntervals||[];(function($){FLBuilderCountdown=function(settings){this.nodeID=settings.id;this.nodeClass='.fl-node-'+settings.id;this.wrapperClass=this.nodeClass+' .fl-countdown';this.dateWrapper=this.nodeClass+' .fl-countdown-days';this.dateLabel=$(this.dateWrapper+' .fl-countdown-unit-label').data('label');this.hoursWrapper=this.nodeClass+' .fl-countdown-hours';this.hoursLabel=$(this.hoursWrapper+' .fl-countdown-unit-label').data('label');this.minutesWrapper=this.nodeClass+' .fl-countdown-minutes';this.minutesLabel=$(this.minutesWrapper+' .fl-countdown-unit-label').data('label');this.secondsWrapper=this.nodeClass+' .fl-countdown-seconds';this.secondsLabel=$(this.secondsWrapper+' .fl-countdown-unit-label').data('label');this.timestamp=settings.time;this.type=settings.type;this.redirect=settings.redirect;this.redirect_url=settings.redirect_url;this._initCountdown();};FLBuilderCountdown.prototype={nodeClass:'',wrapperClass:'',countdown:'',dateWrapper:'',dateLabel:'',hoursWrapper:'',hoursLabel:'',minutesWrapper:'',minutesLabel:'',secondsWrapper:'',secondsLabel:'',timestamp:'',_getTimeRemaining:function(endtime){var t=Date.parse(endtime)-Date.parse(new Date());var seconds=Math.floor((t/1000)%60);var minutes=Math.floor((t/1000/60)%60);var hours=Math.floor((t/(1000*60*60))%24);var days=Math.floor(t/(1000*60*60*24));return{'total':t,'days':(days<10)?('0'+days):days,'hours':('0'+hours).slice(-2),'minutes':('0'+minutes).slice(-2),'seconds':('0'+seconds).slice(-2)};},_setTimeRemaining:function(shouldRedirect){var t=this._getTimeRemaining(this.timestamp),wrappers={days:$(this.dateWrapper),hours:$(this.hoursWrapper),minutes:$(this.minutesWrapper),seconds:$(this.secondsWrapper),},labels={days:this.dateLabel,hours:this.hoursLabel,minutes:this.minutesLabel,seconds:this.secondsLabel,},redirect=shouldRedirect&&'disabled'!==this.redirect||false,url=this.redirect_url||'';if('undefined'!==typeof FLBuilder){redirect=false;} if(t.total<=0){clearInterval(FLBuilderCountdownIntervals[this.nodeID]);$.each(wrappers,function(type,element){element.find('.fl-countdown-unit-number').html('00');});if(!!redirect&&0<url.length){setTimeout(()=>{window.location.href=url;},1000);}}else{$.each(wrappers,function(type,element){element.find('.fl-countdown-unit-number').html(t[type]);var $el=element.find('.fl-countdown-unit-label');var label=parseInt(t[type])!=1?labels[type].plural:labels[type].singular;$el.html(label);});}},_setCircleCount:function(){var t=this._getTimeRemaining(this.timestamp),max={days:365,hours:24,minutes:60,seconds:60},circles={days:$(this.dateWrapper).find('svg'),hours:$(this.hoursWrapper).find('svg'),minutes:$(this.minutesWrapper).find('svg'),seconds:$(this.secondsWrapper).find('svg'),} $.each(circles,function(type,element){var $circle=element.find('.fl-number'),r=$circle.attr('r'),circle=Math.PI*(r*2),val=t[type],total=max[type],stroke=(1-(val / total))*circle;$circle.css({strokeDashoffset:stroke});});},_initCountdown:function(){var self=this;if(0===$(this.wrapperClass).length){return;} clearInterval(FLBuilderCountdownIntervals[this.nodeID]);FLBuilderCountdownIntervals[this.nodeID]=setInterval(function(){self._setTimeRemaining(true);if(self.type=='circle'){self._setCircleCount();}},1000);this._setTimeRemaining('always'===self.redirect);if(this.type=='circle'){this._setCircleCount();}},};})(jQuery);;(function($){$(function(){new FLBuilderCountdown({id:'zij0kf1ax2wn',time:'2024-11-22T23:59:00+00:00',type:'circle',redirect:'disabled',redirect_url:'',});});})(jQuery);;;(function($){$(function(){new FLBuilderCountdown({id:'pou3ks5vc0wl',time:'2024-11-22T23:59:00+00:00',type:'circle',redirect:'disabled',redirect_url:'',});});})(jQuery);(function($){FLThemeBuilderHeaderLayout={win:null,body:null,header:null,overlay:false,hasAdminBar:false,stickyOn:'',breakpointWidth:0,init:function(){var editing=$('html.fl-builder-edit').length,header=$('.fl-builder-content[data-type=header]'),menuModule=header.find('.fl-module-menu'),breakpoint=null;if(!editing&&header.length){header.imagesLoaded($.proxy(function(){this.win=$(window);this.body=$('body');this.header=header.eq(0);this.overlay=!!Number(header.attr('data-overlay'));this.hasAdminBar=!!$('body.admin-bar').length;this.stickyOn=this.header.data('sticky-on');breakpoint=this.header.data('sticky-breakpoint');if(''==this.stickyOn){if(typeof FLBuilderLayoutConfig.breakpoints[breakpoint]!==undefined){this.breakpointWidth=FLBuilderLayoutConfig.breakpoints[breakpoint];} else{this.breakpointWidth=FLBuilderLayoutConfig.breakpoints.medium;}} if(Number(header.attr('data-sticky'))){this.header.data('original-top',this.header.offset().top);this.win.on('resize',$.throttle(500,$.proxy(this._initSticky,this)));this._initSticky();}},this));}},_initSticky:function(e){var header=$('.fl-builder-content[data-type=header]'),windowSize=this.win.width(),makeSticky=false;makeSticky=this._makeWindowSticky(windowSize);if(makeSticky||(this.breakpointWidth>0&&windowSize>=this.breakpointWidth)){this.win.on('scroll.fl-theme-builder-header-sticky',$.proxy(this._doSticky,this));if(e&&'resize'===e.type){if(this.header.hasClass('fl-theme-builder-header-sticky')){this._doSticky(e);} this._adjustStickyHeaderWidth();} if(Number(header.attr('data-shrink'))){this.header.data('original-height',this.header.outerHeight());this.win.on('resize',$.throttle(500,$.proxy(this._initShrink,this)));this._initShrink();} this._initFlyoutMenuFix(e);}else{this.win.off('scroll.fl-theme-builder-header-sticky');this.win.off('resize.fl-theme-builder-header-sticky');this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');}},_makeWindowSticky:function(windowSize){var makeSticky=false;switch(this.stickyOn){case'xl':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['large'];break;case'':case'desktop':makeSticky=windowSize>=FLBuilderLayoutConfig.breakpoints['medium'];break;case'desktop-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small'];break;case'large':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['medium']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'large-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'medium':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']&&windowSize>FLBuilderLayoutConfig.breakpoints['small']);break;case'medium-mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']);break;case'mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['small']);break;case'all':makeSticky=true;break;} return makeSticky;},_doSticky:function(e){var winTop=Math.floor(this.win.scrollTop()),headerTop=Math.floor(this.header.data('original-top')),hasStickyClass=this.header.hasClass('fl-theme-builder-header-sticky'),hasScrolledClass=this.header.hasClass('fl-theme-builder-header-scrolled'),beforeHeader=this.header.prevAll('.fl-builder-content'),bodyTopPadding=parseInt(jQuery('body').css('padding-top')),winBarHeight=$('#wpadminbar').length?$('#wpadminbar').outerHeight():0,headerHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(this.hasAdminBar&&this.win.width()>600){winTop+=Math.floor(winBarHeight);} if(winTop>headerTop){if(!hasStickyClass){if(e&&('scroll'===e.type||'smartscroll'===e.type)){this.header.addClass('fl-theme-builder-header-sticky');if(this.overlay&&beforeHeader.length){this.header.css('top',winBarHeight);}} if(!this.overlay){this._adjustHeaderHeight();}}} else if(hasStickyClass){this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');} this._adjustStickyHeaderWidth();if(winTop>headerTop){if(!hasScrolledClass){this.header.addClass('fl-theme-builder-header-scrolled');}}else if(hasScrolledClass){this.header.removeClass('fl-theme-builder-header-scrolled');} this._flyoutMenuFix(e);},_initFlyoutMenuFix:function(e){var header=this.header,menuModule=header.closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),isPushMenu=menuModule.hasClass('fl-menu-responsive-flyout-push')||menuModule.hasClass('fl-menu-responsive-flyout-push-opacity'),isOverlay=menuModule.hasClass('fl-menu-responsive-flyout-overlay'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',flyoutParent=header.parent().is('header')?header.parent().parent():header.parent();isFullWidth=this.win.width()===header.width(),flyoutLayout='',activePos=250,headerPos=0;if(!flyoutMenu.length){return;} if(this.win.width()>header.parent().width()){headerPos=(this.win.width()-header.width())/ 2;} if(isOverlay){activePos=headerPos;} else 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menuModule.on('click','.fl-menu-mobile-toggle',$.proxy(function(event){if(menuModule.find('.fl-menu-mobile-toggle.fl-active').length){$('html').addClass('fl-theme-builder-flyout-menu-active');event.stopImmediatePropagation();} else{$('html').removeClass('fl-theme-builder-flyout-menu-active');} this._flyoutMenuFix(event);},this));},_flyoutMenuFix:function(e){var header=this.header,menuModule=$(e.target).closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',menuOpacity=menuModule.find('.fl-menu-mobile-opacity'),isScroll='undefined'!==typeof e&&'scroll'===e.handleObj.type,activePos='undefined'!==typeof flyoutMenu.data('activePos')?flyoutMenu.data('activePos'):0,headerPos=(this.win.width()-header.width())/ 2,inactivePos=headerPos>0?activePos+4:254;if(!flyoutMenu.length){return;} if(this.overlay){return;} if($('.fl-theme-builder-flyout-menu-active').length){if(isScroll&&!flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.addClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-header-sticky')){if(!isScroll){setTimeout($.proxy(function(){flyoutMenu.css(flyoutPos,'-'+activePos+'px');},this),1);} else{flyoutMenu.css(flyoutPos,'-'+activePos+'px');}} else{flyoutMenu.css(flyoutPos,'0px');}} else{if(flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.removeClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-flyout-menu-overlay')&&headerPos>0&&headerPos<250){if(header.hasClass('fl-theme-builder-header-sticky')){inactivePos=headerPos+254;} else{inactivePos=254;}} if(e&&e.type==='resize'){inactivePos=headerPos+254;} flyoutMenu.css(flyoutPos,'-'+inactivePos+'px');} if(e&&menuModule.is('.fl-menu-responsive-flyout-overlay')&&$.infinitescroll){e.stopImmediatePropagation();} if(menuOpacity.length){if(header.hasClass('fl-theme-builder-header-sticky')){if('0px'===menuOpacity.css('left')){menuOpacity.css('left','-'+headerPos+'px');}} else{menuOpacity.css('left','');}}},_adjustStickyHeaderWidth:function(){if($('body').hasClass('fl-fixed-width')){var parentWidth=this.header.parent().width();if(this.win.width()>=992){this.header.css({'margin':'0 auto','max-width':parentWidth,});} else{this.header.css({'margin':'','max-width':'',});}}},_adjustHeaderHeight:function(){var beforeHeader=this.header.prevAll('.fl-builder-content'),beforeHeaderHeight=0,beforeHeaderFix=0,headerHeight=Math.floor(this.header.outerHeight()),bodyTopPadding=parseInt($('body').css('padding-top')),wpAdminBarHeight=0,totalHeaderHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(beforeHeader.length){$.each(beforeHeader,function(){beforeHeaderHeight+=Math.floor($(this).outerHeight());});beforeHeaderFix=2;} 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-'+totalHeaderHeight+'px)'});}},_initShrink:function(e){if(this.win.width()>=this.breakpointWidth){this.win.on('scroll.fl-theme-builder-header-shrink',$.proxy(this._doShrink,this));this._setImageMaxHeight();if(this.win.scrollTop()>0){this._doShrink();}}else{this.header.parent().css('padding-top','0');this.win.off('scroll.fl-theme-builder-header-shrink');this._removeShrink();this._removeImageMaxHeight();}},_doShrink:function(e){var winTop=this.win.scrollTop(),headerTop=this.header.data('original-top'),headerHeight=this.header.data('original-height'),shrinkImageHeight=this.header.data('shrink-image-height'),windowSize=this.win.width(),makeSticky=this._makeWindowSticky(windowSize),hasClass=this.header.hasClass('fl-theme-builder-header-shrink');if(this.hasAdminBar){winTop+=32;} if(makeSticky&&(winTop>headerTop+headerHeight)){if(!hasClass){this.header.addClass('fl-theme-builder-header-shrink');this.header.find('img').each(function(i){var image=$(this),maxMegaMenu=image.closest('.max-mega-menu').length,imageInLightbox=image.closest('.fl-button-lightbox-content').length,imageInNavMenu=image.closest('li.menu-item').length;if(!(imageInLightbox||imageInNavMenu||maxMegaMenu)){image.css('max-height',shrinkImageHeight);}});this.header.find('.fl-row-content-wrap').each(function(){var row=$(this);if(parseInt(row.css('padding-bottom'))>5){row.addClass('fl-theme-builder-header-shrink-row-bottom');} if(parseInt(row.css('padding-top'))>5){row.addClass('fl-theme-builder-header-shrink-row-top');}});this.header.find('.fl-module-content').each(function(){var module=$(this);if(parseInt(module.css('margin-bottom'))>5){module.addClass('fl-theme-builder-header-shrink-module-bottom');} if(parseInt(module.css('margin-top'))>5){module.addClass('fl-theme-builder-header-shrink-module-top');}});}}else if(hasClass){this.header.find('img').css('max-height','');this._removeShrink();} 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