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NIDDK Central Repository
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0-.469-.324l-.008-.004A1.8 1.8 0 0 0 5.734 4C4.776 4 4 4.746 4 5.667c0 .92.776 1.666 1.734 1.666.343 0 .662-.095.931-.26-.137.389-.39.804-.81 1.22a.405.405 0 0 0 .011.59c.173.16.447.155.614-.01 1.334-1.329 1.37-2.758.941-3.706a2.5 2.5 0 0 0-.227-.4zM11 7.073c-.136.389-.39.804-.81 1.22a.405.405 0 0 0 .012.59c.172.16.446.155.613-.01 1.334-1.329 1.37-2.758.942-3.706a2.5 2.5 0 0 0-.228-.4 1.7 1.7 0 0 0-.227-.273 1.5 1.5 0 0 0-.469-.324l-.008-.004A1.8 1.8 0 0 0 10.07 4c-.957 0-1.734.746-1.734 1.667 0 .92.777 1.666 1.734 1.666.343 0 .662-.095.931-.26z"></path></svg></div><div><div class="StudyOverview_bold__AxWJY">Citation<a tabindex="0"><svg width="15" height="15" viewBox="0 0 15 15" fill="none" xmlns="http://www.w3.org/2000/svg"><circle cx="7.5" cy="7.5" r="7.5" fill="black"></circle><path d="M6.8437 7.772C6.85303 7.744 6.86236 7.674 6.8717 7.562C6.89036 7.44067 6.8997 7.36133 6.8997 7.324C6.8997 7.25867 6.8857 7.198 6.8577 7.142C6.8297 7.07667 6.77836 7.044 6.7037 7.044C6.61036 7.044 6.48436 7.10933 6.3257 7.24C6.17636 7.36133 6.04103 7.492 5.9197 7.632C5.8077 7.76267 5.74236 7.842 5.7237 7.87C5.67703 7.87 5.63503 7.81867 5.5977 7.716C5.56036 7.61333 5.5417 7.54333 5.5417 7.506C5.5977 7.394 5.70503 7.24933 5.8637 7.072C6.02236 6.89467 6.20436 6.71267 6.4097 6.526C6.61503 6.33933 6.82503 6.18533 7.0397 6.064C7.2637 5.93333 7.46903 5.868 7.6557 5.868C7.92636 5.868 8.1457 5.952 8.3137 6.12C8.49103 6.27867 8.5797 6.51667 8.5797 6.834C8.5797 6.92733 8.56103 7.06733 8.5237 7.254C8.4957 7.44067 8.47236 7.57133 8.4537 7.646L7.9497 10.194C7.94036 10.222 7.92636 10.2967 7.9077 10.418C7.89836 10.53 7.8937 10.6047 7.8937 10.642C7.8937 10.7073 7.9077 10.7727 7.9357 10.838C7.9637 10.9033 8.01036 10.936 8.0757 10.936C8.17836 10.936 8.30436 10.8707 8.4537 10.74C8.60303 10.6093 8.73836 10.4787 8.8597 10.348C8.98103 10.208 9.04636 10.124 9.0557 10.096C9.10236 10.096 9.14436 10.1473 9.1817 10.25C9.21903 10.3527 9.2377 10.4273 9.2377 10.474C9.1817 10.586 9.0697 10.7307 8.9017 10.908C8.74303 11.0853 8.55636 11.2673 8.3417 11.454C8.12703 11.6407 7.9077 11.7993 7.6837 11.93C7.4597 12.0513 7.25436 12.112 7.0677 12.112C6.8437 12.112 6.64303 12.0373 6.4657 11.888C6.2977 11.7293 6.2137 11.4773 6.2137 11.132C6.2137 11.0293 6.2277 10.8847 6.2557 10.698C6.29303 10.502 6.31636 10.376 6.3257 10.32L6.8437 7.772ZM8.2997 2.606C8.53303 2.606 8.72436 2.69 8.8737 2.858C9.02303 3.01667 9.0977 3.21733 9.0977 3.46C9.0977 3.75867 8.99036 4.02933 8.7757 4.272C8.56103 4.50533 8.30903 4.622 8.0197 4.622C7.78636 4.622 7.59503 4.538 7.4457 4.37C7.3057 4.19267 7.2357 3.98733 7.2357 3.754C7.2357 3.45533 7.33836 3.18933 7.5437 2.956C7.75836 2.72267 8.01036 2.606 8.2997 2.606Z" fill="white"></path></svg></a></div><div>Gassman, Jennifer (2020). African American Study of Kidney Disease and Hypertension Study (Clinical Trial)(V8) [Dataset] NIDDK Central Repository. https://doi.org/10.58020/jtkq-h450</div></div></div><div class="StudyOverview_headerItem__s6tLL"><div class="StudyOverview_iconBackground__1EoT_"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" width="20px" height="20px" fill="white" class="bi bi-file-text-fill"><path d="M12 0H4a2 2 0 0 0-2 2v12a2 2 0 0 0 2 2h8a2 2 0 0 0 2-2V2a2 2 0 0 0-2-2M5 4h6a.5.5 0 0 1 0 1H5a.5.5 0 0 1 0-1m-.5 2.5A.5.5 0 0 1 5 6h6a.5.5 0 0 1 0 1H5a.5.5 0 0 1-.5-.5M5 8h6a.5.5 0 0 1 0 1H5a.5.5 0 0 1 0-1m0 2h3a.5.5 0 0 1 0 1H5a.5.5 0 0 1 0-1"></path></svg></div><div><div class="StudyOverview_bold__AxWJY">Data Availability Statement<!-- --> <a tabindex="0"><svg width="15" height="15" viewBox="0 0 15 15" fill="none" xmlns="http://www.w3.org/2000/svg"><circle cx="7.5" cy="7.5" r="7.5" fill="black"></circle><path d="M6.8437 7.772C6.85303 7.744 6.86236 7.674 6.8717 7.562C6.89036 7.44067 6.8997 7.36133 6.8997 7.324C6.8997 7.25867 6.8857 7.198 6.8577 7.142C6.8297 7.07667 6.77836 7.044 6.7037 7.044C6.61036 7.044 6.48436 7.10933 6.3257 7.24C6.17636 7.36133 6.04103 7.492 5.9197 7.632C5.8077 7.76267 5.74236 7.842 5.7237 7.87C5.67703 7.87 5.63503 7.81867 5.5977 7.716C5.56036 7.61333 5.5417 7.54333 5.5417 7.506C5.5977 7.394 5.70503 7.24933 5.8637 7.072C6.02236 6.89467 6.20436 6.71267 6.4097 6.526C6.61503 6.33933 6.82503 6.18533 7.0397 6.064C7.2637 5.93333 7.46903 5.868 7.6557 5.868C7.92636 5.868 8.1457 5.952 8.3137 6.12C8.49103 6.27867 8.5797 6.51667 8.5797 6.834C8.5797 6.92733 8.56103 7.06733 8.5237 7.254C8.4957 7.44067 8.47236 7.57133 8.4537 7.646L7.9497 10.194C7.94036 10.222 7.92636 10.2967 7.9077 10.418C7.89836 10.53 7.8937 10.6047 7.8937 10.642C7.8937 10.7073 7.9077 10.7727 7.9357 10.838C7.9637 10.9033 8.01036 10.936 8.0757 10.936C8.17836 10.936 8.30436 10.8707 8.4537 10.74C8.60303 10.6093 8.73836 10.4787 8.8597 10.348C8.98103 10.208 9.04636 10.124 9.0557 10.096C9.10236 10.096 9.14436 10.1473 9.1817 10.25C9.21903 10.3527 9.2377 10.4273 9.2377 10.474C9.1817 10.586 9.0697 10.7307 8.9017 10.908C8.74303 11.0853 8.55636 11.2673 8.3417 11.454C8.12703 11.6407 7.9077 11.7993 7.6837 11.93C7.4597 12.0513 7.25436 12.112 7.0677 12.112C6.8437 12.112 6.64303 12.0373 6.4657 11.888C6.2977 11.7293 6.2137 11.4773 6.2137 11.132C6.2137 11.0293 6.2277 10.8847 6.2557 10.698C6.29303 10.502 6.31636 10.376 6.3257 10.32L6.8437 7.772ZM8.2997 2.606C8.53303 2.606 8.72436 2.69 8.8737 2.858C9.02303 3.01667 9.0977 3.21733 9.0977 3.46C9.0977 3.75867 8.99036 4.02933 8.7757 4.272C8.56103 4.50533 8.30903 4.622 8.0197 4.622C7.78636 4.622 7.59503 4.538 7.4457 4.37C7.3057 4.19267 7.2357 3.98733 7.2357 3.754C7.2357 3.45533 7.33836 3.18933 7.5437 2.956C7.75836 2.72267 8.01036 2.606 8.2997 2.606Z" fill="white"></path></svg></a></div><div>Data from the African American Study of Kidney Disease and Hypertension Study (Clinical Trial)[(V8) https://doi.org/10.58020/jtkq-h450] reported here are available for request at the NIDDK Central Repository (NIDDK-CR) website, Resources for Research (R4R), https://repository.niddk.nih.gov/.</div></div></div><div class="StudyOverview_headerItem__s6tLL"><div class="StudyOverview_iconBackground__1EoT_"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" width="20px" height="20px" fill="white" class="bi bi-file-earmark-check-fill"><path d="M9.293 0H4a2 2 0 0 0-2 2v12a2 2 0 0 0 2 2h8a2 2 0 0 0 2-2V4.707A1 1 0 0 0 13.707 4L10 .293A1 1 0 0 0 9.293 0M9.5 3.5v-2l3 3h-2a1 1 0 0 1-1-1m1.354 4.354-3 3a.5.5 0 0 1-.708 0l-1.5-1.5a.5.5 0 1 1 .708-.708L7.5 9.793l2.646-2.647a.5.5 0 0 1 .708.708"></path></svg></div><div><div class="StudyOverview_bold__AxWJY">Acknowledgment Statement<!-- --> <a tabindex="0"><svg width="15" height="15" viewBox="0 0 15 15" fill="none" xmlns="http://www.w3.org/2000/svg"><circle cx="7.5" cy="7.5" r="7.5" fill="black"></circle><path d="M6.8437 7.772C6.85303 7.744 6.86236 7.674 6.8717 7.562C6.89036 7.44067 6.8997 7.36133 6.8997 7.324C6.8997 7.25867 6.8857 7.198 6.8577 7.142C6.8297 7.07667 6.77836 7.044 6.7037 7.044C6.61036 7.044 6.48436 7.10933 6.3257 7.24C6.17636 7.36133 6.04103 7.492 5.9197 7.632C5.8077 7.76267 5.74236 7.842 5.7237 7.87C5.67703 7.87 5.63503 7.81867 5.5977 7.716C5.56036 7.61333 5.5417 7.54333 5.5417 7.506C5.5977 7.394 5.70503 7.24933 5.8637 7.072C6.02236 6.89467 6.20436 6.71267 6.4097 6.526C6.61503 6.33933 6.82503 6.18533 7.0397 6.064C7.2637 5.93333 7.46903 5.868 7.6557 5.868C7.92636 5.868 8.1457 5.952 8.3137 6.12C8.49103 6.27867 8.5797 6.51667 8.5797 6.834C8.5797 6.92733 8.56103 7.06733 8.5237 7.254C8.4957 7.44067 8.47236 7.57133 8.4537 7.646L7.9497 10.194C7.94036 10.222 7.92636 10.2967 7.9077 10.418C7.89836 10.53 7.8937 10.6047 7.8937 10.642C7.8937 10.7073 7.9077 10.7727 7.9357 10.838C7.9637 10.9033 8.01036 10.936 8.0757 10.936C8.17836 10.936 8.30436 10.8707 8.4537 10.74C8.60303 10.6093 8.73836 10.4787 8.8597 10.348C8.98103 10.208 9.04636 10.124 9.0557 10.096C9.10236 10.096 9.14436 10.1473 9.1817 10.25C9.21903 10.3527 9.2377 10.4273 9.2377 10.474C9.1817 10.586 9.0697 10.7307 8.9017 10.908C8.74303 11.0853 8.55636 11.2673 8.3417 11.454C8.12703 11.6407 7.9077 11.7993 7.6837 11.93C7.4597 12.0513 7.25436 12.112 7.0677 12.112C6.8437 12.112 6.64303 12.0373 6.4657 11.888C6.2977 11.7293 6.2137 11.4773 6.2137 11.132C6.2137 11.0293 6.2277 10.8847 6.2557 10.698C6.29303 10.502 6.31636 10.376 6.3257 10.32L6.8437 7.772ZM8.2997 2.606C8.53303 2.606 8.72436 2.69 8.8737 2.858C9.02303 3.01667 9.0977 3.21733 9.0977 3.46C9.0977 3.75867 8.99036 4.02933 8.7757 4.272C8.56103 4.50533 8.30903 4.622 8.0197 4.622C7.78636 4.622 7.59503 4.538 7.4457 4.37C7.3057 4.19267 7.2357 3.98733 7.2357 3.754C7.2357 3.45533 7.33836 3.18933 7.5437 2.956C7.75836 2.72267 8.01036 2.606 8.2997 2.606Z" fill="white"></path></svg></a></div><div class="StudyOverview_scrollable__CwSLo">The African American Study of Kidney Disease and Hypertension Study (Clinical Trial) (AASK Trial) was conducted by the AASK Trial Investigators and supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The data and biospecimens from the AASK Trial (https://doi.org/10.58020/jtkq-h450) reported here were supplied by NIDDK Central Repository (NIDDK-CR) and are available for request at https://repository.niddk.nih.gov. This manuscript was not prepared under the auspices of the AASK Trial study and does not necessarily reflect the opinions or views of the AASK Trial study, NIDDK-CR, or NIDDK.</div></div></div></div><div class="StudyOverview_topRightContainer__8bxiG col-lg-3"><div class="StudyOverview_graybox__SoeAQ StudyOverview_pubBox__tK9w9"><div class="StudyOverview_bold__AxWJY">Resource Availability</div><div>Specimens and Study Datasets</div><a href="/user/login/?next=/requests/type/aask-trial" class="StudyOverview_centerButton__vY44L"><button aria-label="Login to Start a Request" class="Button_button__OFOdO Button_auto__peQWd Button_primary__WTwSy a a-primary">Login to Start a Request</button></a></div><div class="StudyOverview_graybox__SoeAQ StudyOverview_pubBox__tK9w9"><div class="StudyOverview_bold__AxWJY">Publications</div><div>Explore publications resulting from the use of study resource</div><a href="/publications?&facets=%5B%7B%22name%22:%22study_acronym_array%22,%22facets%22:%5B%22AASK%20Trial%22%5D%7D%5D">View publications (14)</a></div></div></div><div class="StudyOverview_Row___uK4C row"><div class="StudyOverview_Col__Ho7wa col"><div tabindex="0" id="0" aria-label="Study Overview collapsable section" class=" StudyOverview_accordion__xGdM_ undefined accordion"><div class="undefined Accordion_dataItem__pZkIy accordion-item"><h2 class="undefined Accordion_dataHeader__8IWP_ accordion-header"><button type="button" aria-expanded="true" class="accordion-button"><svg width="18" height="10" viewBox="0 0 22 10" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M1 1.49609L10.8765 8.63072L21 1.49609" stroke="currentColor" stroke-width="2"></path></svg>Study Overview</button></h2><div class="accordion-collapse collapse show"><div class="undefined Accordion_dataBody__qQzXM accordion-body"><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">General Description</div><div><p>The African American Study of Kidney Disease and Hypertension study (AASK Trial) was a multi-center, randomized clinical trial that investigated the effects of blood pressure (BP) control and the use of specific antihypertensive regimens on the progression of chronic kidney disease (CKD). The study was designed to address the high incidence of CKD in African Americans with hypertension. A two by three factorial study design, including two levels of BP control as defined by mean arterial pressure (MAP) and three different anti-hypertensive regimens, was used. Participants were randomized into two levels of BP control groups, either a goal MAP < 92 mmHg or a goal MAP between 102-107 mmHg inclusive.. The antihypertensive drugs used for treatment were amlodipine, a calcium channel blocker; ramipril, an angiotensin-converting enzyme inhibitor; and metoprolol, a β-blocker. The trial was double-blind (drug administration only). The change in glomerular filtration rate (GFR) as determined by iothalamate clearance was measured as the primary outcome to test the regimens’ efficacy in slowing the rate of decline of kidney function.</p> <p>The study showed that the angiotensin-converting enzyme inhibitor ramipril was more effective than the beta blocker metoprolol or the dihydropyridine calcium channel blocker amlodipine in slowing the rate of GFR decline. The results suggest that reduction in blood pressure to levels below those currently advocated for cardiovascular risk reduction does not provide readily identifiable benefits to African Americans with hypertensive nephrosclerosis.</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Objectives</div><div><p>The AASK study aimed to determine the effects of a lower than usual level of blood pressure control and the use of specific antihypertensive regimens on the progression of renal insufficiency that was clinically attributed to the effects of hypertension on the kidney. Two levels of BP control and 3 different antihypertensive regimens were tested for efficacy in slowing the rate of decline of renal function.</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Outcome Measure</div><div><p>The primary outcome measure was change in GFR as determined by iothalamate clearance. Secondary outcome measures included a time-to-event analysis of reduction in GFR by 50% or by 25 ml/min/1.73m2, end-stage renal disease (ESRD), and death to determine the clinical impact of the interventions.</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Eligibility Criteria</div><div><p>The study enrolled African-American men and women between 18 and 70 years of age who presented with hypertension (defined as a sitting diastolic blood pressure of 95 mmHg or more) and reduced renal function (defined as a pre-randomization 125I-iothalamate glomerular filtration rate between 20 65 ml/min/1.73m2).</p> <p>Exclusion criteria are documented in the study protocol.</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Outcome</div><div><p>Results of the AASK study showed that the angiotensin-converting enzyme inhibitor ramipril was was more effective than the beta blocker metoprolol or the dihydropyridine calcium channel blocker amlodipine in slowing the rate of glomerular filtration rate decline in African American patients with mild to moderate renal insufficiency. Notably, there was no significant difference in the rate of decline in kidney function between the 92 mmHg or less and the 102-107 mmHg MAP groups. The study suggests that reduction in blood pressure to levels below those currently advocated for cardiovascular risk reduction does not provide readily identifiable benefits to African Americans with hypertensive nephrosclerosis. While this study provides the basis for the primary use of angiotensin-converting enzyme inhibitors in an African American population, it is undetermined if this represents a class effect for all angiotensin-converting enzyme inhibitors.</p></div></div></div></div></div></div></div></div><div class="StudyOverview_Row___uK4C row"><div class="StudyOverview_Col__Ho7wa StudyOverview_largeCol__J7XDJ col"><div tabindex="0" id="1" aria-label="Study Details collapsable section" class=" StudyOverview_accordion__xGdM_ undefined accordion"><div class="undefined Accordion_dataItem__pZkIy accordion-item"><h2 class="undefined Accordion_dataHeader__8IWP_ accordion-header"><button type="button" aria-expanded="false" class="accordion-button collapsed"><svg width="18" height="10" viewBox="0 0 22 10" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M1 1.49609L10.8765 8.63072L21 1.49609" stroke="currentColor" stroke-width="2"></path></svg>Study Details</button></h2><div class="accordion-collapse collapse"><div class="undefined Accordion_dataBody__qQzXM accordion-body"><div class="StudyOverview_detailsListContainer__vV7es"><div class="StudyOverview_detailsList__jFVUF"><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Research Area</div><div><p>Kidney Disease, Multidisciplinary Research</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Study Type</div><div><p>Interventional</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Study Sites</div><div><p>21</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Study Start Date</div><div><p>1995-02</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Study End Date</div><div><p>2007-06</p></div></div></div><div class="StudyOverview_detailsList__jFVUF"><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Condition</div><div><p>Hypertensive Disorder, Cardiovascular Disorder, Chronic Kidney Disease</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Clinical Trials URL</div><div class="StudyOverview_wordBreak__n5aYp"><p><a href="https://www.clinicaltrials.gov/study/NCT04364139" target="_blank" rel="noopener noreferrer">https://www.clinicaltrials.gov/study/NCT04364139</a></p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Keywords</div><div><p>Kidney Disease, Blood Pressure Control, MAP, Renal Insufficiency, Mean Arterial Pressure, Cardiovascular Disease, Hypertension, Drug Therapy, Chronic Kidney Disease (CKD), Glomerular Filtration Rate (GFR)</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">NIDDK Division</div><div><p>KUH</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Network</div><a href="/network/222" target="_blank" rel="noopener noreferrer">African American Study of Kidney Disease Study Group (AASK)</a></div></div></div></div></div></div></div></div></div><div class="StudyOverview_Row___uK4C row"><div class="StudyOverview_Col__Ho7wa StudyOverview_smallCol__ElwmY col"><div tabindex="0" id="1" aria-label="Study Population collapsable section" class=" StudyOverview_accordion__xGdM_ undefined accordion"><div class="undefined Accordion_dataItem__pZkIy accordion-item"><h2 class="undefined Accordion_dataHeader__8IWP_ accordion-header"><button type="button" aria-expanded="false" class="accordion-button collapsed"><svg width="18" height="10" viewBox="0 0 22 10" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M1 1.49609L10.8765 8.63072L21 1.49609" stroke="currentColor" stroke-width="2"></path></svg>Study Population</button></h2><div class="accordion-collapse collapse"><div class="undefined Accordion_dataBody__qQzXM accordion-body"><div class="StudyOverview_section__kATqU"><div class="HighchartsCharts_Row__Xnc9d row"><div class="HighchartsCharts_Col__tL81L HighchartsCharts_populationContainer__lQh_v col-lg-4"><div class="HighchartsCharts_section__zzKnl HighchartsCharts_centerText__a_y4Q"><div class="HighchartsCharts_studyPopNumber__aGjwH">3,017</div><div class="HighchartsCharts_studyPopDescription__1j5UH">Participants</div><hr/><div class="HighchartsCharts_targetPop__veD08">Target Population</div><div>Adults</div></div></div><div class="HighchartsCharts_Col__tL81L col-lg-4"><div></div></div><div class="HighchartsCharts_Col__tL81L col-lg-4"><div></div></div><div class="HighchartsCharts_Col__tL81L col-lg-4"><div></div></div><div class="HighchartsCharts_Col__tL81L col-lg-4"><div></div></div><div class="HighchartsCharts_Col__tL81L col-lg-4"><div class="HighchartsCharts_noDataContainer__lbToy"><div class="HighchartsCharts_noData__Mrrqb HighchartsCharts_lightBox__jISFO">Location statistics is not available for this study</div></div></div></div></div></div></div></div></div></div></div><div class="StudyOverview_Row___uK4C row"><div class="StudyOverview_Col__Ho7wa col"><div tabindex="0" id="1" aria-label="Public Documents (107) collapsable section" class=" StudyOverview_accordion__xGdM_ undefined accordion"><div class="undefined Accordion_dataItem__pZkIy accordion-item"><h2 class="undefined Accordion_dataHeader__8IWP_ accordion-header"><button type="button" aria-expanded="false" class="accordion-button collapsed"><svg width="18" height="10" viewBox="0 0 22 10" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M1 1.49609L10.8765 8.63072L21 1.49609" stroke="currentColor" stroke-width="2"></path></svg>Public Documents (107)</button></h2><div class="accordion-collapse collapse"><div class="undefined Accordion_dataBody__qQzXM accordion-body"><div><div class="Table_spaceBetween__8htMZ"><button aria-label="Expand All Rows" class="Button_button__OFOdO Button_auto__peQWd Table_expandCollapseBtn__6RnKT Button_primary__WTwSy a a-primary">Expand All Rows</button><div><a href="https://repository.niddk.nih.gov/api/entity/v1/study/documents/download/56" download=""><button aria-label="Download All Public Documents" class="Button_button__OFOdO Button_auto__peQWd Button_primary__WTwSy a a-primary">Download All Public Documents</button></a></div></div><div tabindex="0" class="StudyOverview_tableContainer__8p4vy Table_narrowPadding__nEChe Table_container__Y2W_q Table_offWhite__TTPPQ"><table role="table" class="Table_table__b_0YI table table-sm table-striped table-bordered"><caption class="sr-only">Public Documents Table</caption><thead><tr><th tabindex="0" colSpan="1" style="width:320px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_textHeader__nU1f7">Document Name</div></div></th><th tabindex="0" colSpan="1" style="width:300px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_textHeader__nU1f7">Description</div></div></th><th tabindex="0" colSpan="1" style="width:180px" class=""><div class=""><div class="Table_textHeader__nU1f7">Document Type</div></div></th><th tabindex="0" colSpan="1" style="width:120px" class=""><div class=""><div class="Table_textHeader__nU1f7">File Format</div></div></th><th tabindex="0" colSpan="1" style="width:130px" class=""><div class=""><div class="Table_textHeader__nU1f7">Compliance</div></div></th><th tabindex="0" colSpan="1" style="width:120px" class=""><div class=""><div class="Table_textHeader__nU1f7">Download</div></div></th></tr></thead><tbody><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Codebook/Data Dictionary</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "><span></span></td><td tabindex="0" class=" "><span></span></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Dataset Integrity Check</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "><span></span></td><td tabindex="0" class=" "><span></span></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Data Description</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "><span></span></td><td tabindex="0" class=" "><span></span></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Data Collection Instruments/Forms</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "><span></span></td><td tabindex="0" class=" "><span></span></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Manual of Operations/Procedures</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "><span></span></td><td tabindex="0" class=" "><span></span></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Project Summaries</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "><span></span></td><td tabindex="0" class=" "><span></span></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Roadmap File</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "><span></span></td><td tabindex="0" class=" "><span></span></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Study Protocol</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "><span></span></td><td tabindex="0" class=" "><span></span></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td></tr></tbody></table></div></div></div></div></div></div></div></div><div class="StudyOverview_Row___uK4C row"><div class="StudyOverview_Col__Ho7wa col"><div tabindex="0" id="1" aria-label="Resources Available on Request collapsable section" class=" StudyOverview_accordion__xGdM_ undefined accordion"><div class="undefined Accordion_dataItem__pZkIy accordion-item"><h2 class="undefined Accordion_dataHeader__8IWP_ accordion-header"><button type="button" aria-expanded="false" class="accordion-button collapsed"><svg width="18" height="10" viewBox="0 0 22 10" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M1 1.49609L10.8765 8.63072L21 1.49609" stroke="currentColor" stroke-width="2"></path></svg>Resources Available on Request</button></h2><div class="accordion-collapse collapse"><div class="undefined Accordion_dataBody__qQzXM accordion-body"><div class="StudyOverview_nonPublicDocsHeader__5_TOJ"><div class="StudyOverview_sectionTitle__m4Z_f">Non-Public Documents (6)</div></div><div><div class="Table_spaceBetween__8htMZ"><button aria-label="Expand All Rows" class="Button_button__OFOdO Button_auto__peQWd Table_expandCollapseBtn__6RnKT Button_primary__WTwSy a a-primary">Expand All Rows</button></div><div tabindex="0" class="StudyOverview_tableContainer__8p4vy Table_narrowPadding__nEChe Table_container__Y2W_q Table_offWhite__TTPPQ"><table role="table" class="Table_table__b_0YI table table-sm table-striped table-bordered"><caption class="sr-only">Non-Public Documents Table</caption><thead><tr><th tabindex="0" colSpan="1" style="width:320px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_textHeader__nU1f7">Document Name</div></div></th><th tabindex="0" colSpan="1" style="width:300px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_textHeader__nU1f7">Description</div></div></th><th tabindex="0" colSpan="1" style="width:180px" class=""><div class=""><div class="Table_textHeader__nU1f7">Document Type</div></div></th><th tabindex="0" colSpan="1" style="width:120px" class=""><div class=""><div class="Table_textHeader__nU1f7">File Format</div></div></th></tr></thead><tbody><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Data Description</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "><span></span></td><td tabindex="0" class=" "><span></span></td><td tabindex="0" class=" "></td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Data Collection Instruments/Forms</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "><span></span></td><td tabindex="0" class=" "><span></span></td><td tabindex="0" class=" "></td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Formats/Dataset Instruction</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "><span></span></td><td tabindex="0" class=" "><span></span></td><td tabindex="0" class=" "></td></tr></tbody></table></div></div><div class="StudyOverview_datasetsHeader__eNhSK"><div class="StudyOverview_sectionTitle__m4Z_f">Datasets (75)</div></div><div><div class="Table_spaceBetween__8htMZ"><button aria-label="Expand All Rows" class="Button_button__OFOdO Button_auto__peQWd Table_expandCollapseBtn__6RnKT Button_primary__WTwSy a a-primary">Expand All Rows</button></div><div tabindex="0" class="StudyOverview_tableContainer__8p4vy Table_narrowPadding__nEChe Table_container__Y2W_q Table_offWhite__TTPPQ"><table role="table" class="Table_table__b_0YI table table-sm table-striped table-bordered"><caption class="sr-only">Datasets Table</caption><thead><tr><th tabindex="0" colSpan="1" style="width:320px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_textHeader__nU1f7">Dataset Name</div></div></th><th tabindex="0" colSpan="1" style="width:340px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_textHeader__nU1f7">Description</div></div></th><th tabindex="0" colSpan="1" style="width:120px" class=""><div class=""><div class="Table_textHeader__nU1f7"># of Records</div></div></th><th tabindex="0" colSpan="1" style="width:130px" class=""><div class=""><div class="Table_textHeader__nU1f7"># of Variables</div></div></th><th tabindex="0" colSpan="1" style="width:150px" class=""><div class=""><div class="Table_textHeader__nU1f7">File Format(s)</div></div></th></tr></thead><tbody><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Form_Based_Data</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Analysis_Data</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>APOL1_Data</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td></tr></tbody></table></div></div><div class="StudyOverview_specimensHeader__dogXp"><div class="StudyOverview_sectionTitle__m4Z_f">Specimens (39,449)</div></div><div><div tabindex="0" class="StudyOverview_tableContainer__8p4vy StudyOverview_specimensTable__TCiZc Table_narrowPadding__nEChe Table_container__Y2W_q Table_offWhite__TTPPQ"><table role="table" class="Table_table__b_0YI table table-sm table-striped table-bordered"><caption class="sr-only">Specimens Table</caption><thead><tr><th tabindex="0" colSpan="1" style="width:200px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_textHeader__nU1f7">Specimen</div></div></th><th tabindex="0" colSpan="1" style="width:100px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_textHeader__nU1f7">Count</div></div></th></tr></thead><tbody><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l">Buffy Coat</td><td tabindex="0" class="Table_alignLeft__VdU8l">852</td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l">DNA</td><td tabindex="0" class="Table_alignLeft__VdU8l">7941</td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l">Serum</td><td tabindex="0" class="Table_alignLeft__VdU8l">17760</td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l">Urine</td><td tabindex="0" class="Table_alignLeft__VdU8l">12896</td></tr></tbody></table></div></div></div></div></div></div></div></div></div><footer 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African American Study of Kidney Disease and Hypertension Study (Clinical Trial)(V8) [Dataset] NIDDK Central Repository. https://doi.org/10.58020/jtkq-h450"],"label":"How to cite this dataset"},{"propertyValue":["Data from the African American Study of Kidney Disease and Hypertension Study (Clinical Trial)[(V8) https://doi.org/10.58020/jtkq-h450] reported here are available for request at the NIDDK Central Repository (NIDDK-CR) website, Resources for Research (R4R), https://repository.niddk.nih.gov/."],"label":"Data Availability Statement"},{"propertyValue":["The African American Study of Kidney Disease and Hypertension Study (Clinical Trial) (AASK Trial) was conducted by the AASK Trial Investigators and supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The data and biospecimens from the AASK Trial (https://doi.org/10.58020/jtkq-h450) reported here were supplied by NIDDK Central Repository (NIDDK-CR) and are available for request at https://repository.niddk.nih.gov. This manuscript was not prepared under the auspices of the AASK Trial study and does not necessarily reflect the opinions or views of the AASK Trial study, NIDDK-CR, or NIDDK."],"label":"Acknowledgement Statement"}],"Population":[{"propertyValue":["Adults"],"label":"Target Population"}],"Title":[{"propertyValue":["African American Study of Kidney Disease and Hypertension Study (Clinical Trial)"],"label":"Study Name"},{"propertyValue":["AASK Trial"],"label":"Study Acronym"}],"Hidden":[{"propertyValue":["222"],"label":"Network ID"},{"propertyValue":["Data Available for Request"],"label":"has data"},{"propertyValue":["aask-trial"],"label":"slug"},{"propertyValue":["Specimens Available for Request"],"label":"specimen availability"}],"Representative":[{"propertyValue":["The African American Study of Kidney Disease and Hypertension study (AASK Trial) was a multi-center, randomized clinical trial that investigated the effects of blood pressure (BP) control and the use of specific antihypertensive regimens on the progression of chronic kidney disease (CKD). The study was designed to address the high incidence of CKD in African Americans with hypertension. A two by three factorial study design, including two levels of BP control as defined by mean arterial pressure (MAP) and three different anti-hypertensive regimens, was used. Participants were randomized into two levels of BP control groups, either a goal MAP \u003c 92 mmHg or a goal MAP between 102-107 mmHg inclusive.. The antihypertensive drugs used for treatment were amlodipine, a calcium channel blocker; ramipril, an angiotensin-converting enzyme inhibitor; and metoprolol, a β-blocker. The trial was double-blind (drug administration only). The change in glomerular filtration rate (GFR) as determined by iothalamate clearance was measured as the primary outcome to test the regimens’ efficacy in slowing the rate of decline of kidney function.\r\n \r\nThe study showed that the angiotensin-converting enzyme inhibitor ramipril was more effective than the beta blocker metoprolol or the dihydropyridine calcium channel blocker amlodipine in slowing the rate of GFR decline. The results suggest that reduction in blood pressure to levels below those currently advocated for cardiovascular risk reduction does not provide readily identifiable benefits to African Americans with hypertensive nephrosclerosis."],"label":"General Description"},{"propertyValue":["The AASK study aimed to determine the effects of a lower than usual level of blood pressure control and the use of specific antihypertensive regimens on the progression of renal insufficiency that was clinically attributed to the effects of hypertension on the kidney. Two levels of BP control and 3 different antihypertensive regimens were tested for efficacy in slowing the rate of decline of renal function."],"label":"Objectives"},{"propertyValue":["The primary outcome measure was change in GFR as determined by iothalamate clearance. Secondary outcome measures included a time-to-event analysis of reduction in GFR by 50% or by 25 ml/min/1.73m2, end-stage renal disease (ESRD), and death to determine the clinical impact of the interventions."],"label":"Outcome Measure"},{"propertyValue":["The study enrolled African-American men and women between 18 and 70 years of age who presented with hypertension (defined as a sitting diastolic blood pressure of 95 mmHg or more) and reduced renal function (defined as a pre-randomization 125I-iothalamate glomerular filtration rate between 20 65 ml/min/1.73m2).\r\n \r\nExclusion criteria are documented in the study protocol."],"label":"Eligibility Criteria"},{"propertyValue":["Results of the AASK study showed that the angiotensin-converting enzyme inhibitor ramipril was was more effective than the beta blocker metoprolol or the dihydropyridine calcium channel blocker amlodipine in slowing the rate of glomerular filtration rate decline in African American patients with mild to moderate renal insufficiency. Notably, there was no significant difference in the rate of decline in kidney function between the 92 mmHg or less and the 102-107 mmHg MAP groups. The study suggests that reduction in blood pressure to levels below those currently advocated for cardiovascular risk reduction does not provide readily identifiable benefits to African Americans with hypertensive nephrosclerosis. While this study provides the basis for the primary use of angiotensin-converting enzyme inhibitors in an African American population, it is undetermined if this represents a class effect for all angiotensin-converting enzyme inhibitors."],"label":"Outcome"}],"Detail":[{"propertyValue":["Kidney Disease","Multidisciplinary Research"],"label":"Research Area"},{"propertyValue":["Interventional"],"label":"Study Type"},{"propertyValue":["21"],"label":"Study Sites"},{"propertyValue":["1995-02"],"label":"Study Start Date"},{"propertyValue":["2007-06"],"label":"Study End Date"},{"propertyValue":["Hypertensive Disorder","Cardiovascular Disorder","Chronic Kidney Disease"],"label":"Condition"},{"propertyValue":["https://www.clinicaltrials.gov/study/NCT04364139"],"label":"Clinical Trials URL"},{"propertyValue":["Kidney Disease","Blood Pressure Control","MAP","Renal Insufficiency","Mean Arterial Pressure","Cardiovascular Disease","Hypertension","Drug Therapy","Chronic Kidney Disease (CKD)","Glomerular Filtration Rate (GFR)"],"label":"Keywords"},{"propertyValue":["KUH"],"label":"NIDDK Division"},{"propertyValue":["African American Study of Kidney Disease Study Group (AASK)"],"label":"Network"}]},"pubCount":14,"publicDocs":{"documents":{"Codebook/Data Dictionary":[{"id":101,"filePath":"AASK_Documents/AASK Trial_Data_Dictionary.pdf","title":"AASK Trial Data Dictionary","description":"Data Dictionary used as a collection of metadata - defines the variable contents of each dataset (version: November 2, 2020)","format":"pdf","size":670,"compliance":"Non-Compliant","displayOrder":1010},{"id":110,"filePath":"AASK_Data/Form_Based_Data/Documents/AASK_columns_of_all_csv_files.xls","title":"AASK Trial Form-Based Data Dictionary","description":"Data Dictionary used as a collection of metadata - defines the variable contents of each form-based dataset","format":"xls","size":56,"compliance":"Non-Compliant","displayOrder":1100}],"Dataset Integrity Check":[{"id":1,"filePath":"AASK_Documents/AASK DSIC/AASK_IntegrityCheckMemo_NoFullText_V1.pdf","title":"Dataset Integrity Check - No Full Text (Wright et al., 2002)","description":"Dataset Integrity Check (DSIC) performed to replicate the results for the data in the publication by Wright et al. (2002) in Journal of the American Medical Assocation","format":"pdf","size":87,"compliance":"Non-Compliant","displayOrder":10},{"id":2,"filePath":"AASK_Documents/AASK DSIC/AASK_IntegrityCheckMemo_V1.pdf","title":"Dataset Integrity Check (Wright et al., 2002)","description":"Dataset Integrity Check (DSIC) performed to replicate the results for the data in the publication by Wright et al. (2002) in Journal of the American Medical Assocation","format":"pdf","size":92,"compliance":"Non-Compliant","displayOrder":20},{"id":3,"filePath":"AASK_Documents/AASK DSIC/AASK_Trial_MDRD_Lab_Data_DSICmod.pdf","title":"Dataset Integrity Check (Inker et al., 2012 and 2016 and Levey et al., 2009)","description":"Dataset Integrity Check (DSIC) performed to replicate the results for the data in the publication by Inker et al. (2016) in the American Journal of Kidney Disease, Inker et al. (2012) in the New England Journal of Medicine, and Levey et al. (2009) in Annals of Internal Medicine","format":"pdf","size":249,"compliance":"Non-Compliant","displayOrder":30}],"Data Description":[{"id":4,"filePath":"AASK_Documents/AASK Forms/AASK List of Forms and Data.doc","title":"AASK List of Forms and Data","description":"Provides a description of every form, document, and dataset, including the number of records for each dataset (version: May 23, 1997)","format":"doc","size":79,"compliance":"Non-Compliant","displayOrder":40},{"id":70,"filePath":"AASK_Documents/AASK Forms/archived_formlist_date_sum.xls","title":"Archived Form List and Corresponding Date Variables","description":"Lists each form number, table name, archived table name, version, date field, and any notes","format":"xls","size":47,"compliance":"Non-Compliant","displayOrder":700},{"id":103,"filePath":"AASK_Documents/AASK_V8_Duplicate Files Read Me.xlsx","title":"AASK Trail Duplicate Files Read Me","description":"This ReadMe document contains a listing of files in the AASK Trial 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size, scale, nulls, default value, and form numbers","format":"xls","size":289,"compliance":"Non-Compliant","displayOrder":1120},{"id":113,"filePath":"AASK_Data/Form_Based_Data/Documents/AASK_tables_fields.xls","title":"AASK Trial Form-Based Table Fields","description":"Provides a list of each form-based dataset's table name","format":"xls","size":274,"compliance":"Non-Compliant","displayOrder":1130},{"id":104,"filePath":"AASK_Data/Analysis_Data/AASK_Analysis_20020409/AASK_Trial_Analysis_20020409.rtf","title":"AASK Trial Analysis (2002) Datasets Proc Contents","description":"Contains the SAS Proc Contents output for analysis datasets as of April 9, 2002","format":"rtf","size":367,"compliance":"Non-Compliant","displayOrder":1040},{"id":106,"filePath":"AASK_Data/Analysis_Data/AASK_Analysis_Current/AASK_Trial_Analysis_Current.rtf","title":"AASK Trial Analysis (Current) Datasets Proc Contents","description":"Contains the SAS Proc Contents output for current analysis 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