Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains

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new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="rFAzfWZhmdhUw895D9mCnkWXe2ZOSCpWe0bLN41t3X8MLCGYMcppSpZIozaNLKOt"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="rFAzfWZhmdhUw895D9mCnkWXe2ZOSCpWe0bLN41t3X8MLCGYMcppSpZIozaNLKOt"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="rFAzfWZhmdhUw895D9mCnkWXe2ZOSCpWe0bLN41t3X8MLCGYMcppSpZIozaNLKOt"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="rFAzfWZhmdhUw895D9mCnkWXe2ZOSCpWe0bLN41t3X8MLCGYMcppSpZIozaNLKOt"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="10330134"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" 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data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="rFAzfWZhmdhUw895D9mCnkWXe2ZOSCpWe0bLN41t3X8MLCGYMcppSpZIozaNLKOt"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio" id="collections-action-dialog-new" class="collections-new" name="collections" value="new" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio" id="collections-action-dialog-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="collections_button" data-ga-action="click" data-ga-label="add"> Add </button><button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="collections_button" data-ga-action="click" data-ga-label="cancel"> Cancel </button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" 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journal Molecular and cellular biology" data-pinger-ignore> Mol Cell Biol </button><div id="full-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal Molecular and cellular biology"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Mol+Cell+Biol%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22Mol+Cell+Biol%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=Mol Cell Biol" data-ga-category="search" data-ga-action="journal_link" data-ga-label="Mol Cell Biol"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Mol+Cell+Biol%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" 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Iwama</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Hematology/Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Pan+J&cauthor_id=10330134" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="J Pan">J Pan</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Zhang+P&cauthor_id=10330134" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="P Zhang">P Zhang</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Reith+W&cauthor_id=10330134" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="W Reith">W Reith</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Mach+B&cauthor_id=10330134" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="B Mach">B Mach</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Tenen+DG&cauthor_id=10330134" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="D G Tenen">D G Tenen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sun+Z&cauthor_id=10330134" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Z Sun">Z Sun</a></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" 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class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">A Iwama</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> Mol Cell Biol<span class="citation-separator">.</span> </span> <span class="date"> <span class="citation-year">1999 Jun</span><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" aria-controls="full-article-details" aria-expanded="false" data-fetch-url="/10330134/long-authors/" data-id-prefix=""> <span class="title">Show details</span> </button> <div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"> <button class="trigger usa-button" title="Change format" data-ga-category="display_options" 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title="Hematology/Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Pan+J&cauthor_id=10330134" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="J Pan">J Pan</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Zhang+P&cauthor_id=10330134" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="P Zhang">P Zhang</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Reith+W&cauthor_id=10330134" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="W Reith">W Reith</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Mach+B&cauthor_id=10330134" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="B Mach">B Mach</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Tenen+DG&cauthor_id=10330134" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="D G Tenen">D G Tenen</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sun+Z&cauthor_id=10330134" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Z Sun">Z Sun</a></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Hematology/Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">10330134</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC104353&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC104353/" data-ga-category="full_text" data-ga-action="PMCID" > PMC104353 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1128/MCB.19.6.3940&id_type=DOI" href="https://doi.org/10.1128/mcb.19.6.3940" data-ga-category="full_text" data-ga-action="DOI" > 10.1128/MCB.19.6.3940 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/10330134/citations/" data-citation-style="nlm" data-pubmed-format-link="/10330134/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> Interleukin-5 (IL-5) plays a central role in the differentiation, proliferation, and functional activation of eosinophils. The specific action of IL-5 on eosinophils and hematopoietically related basophils is regulated by the restricted expression of IL-5 receptor alpha (IL-5Ralpha), a subunit of high-affinity IL-5R, on these cells. We have previously identified an enhancer-like cis element in the IL-5Ralpha promoter that is important for both full promoter function and lineage-specific activity. Here, we demonstrate by yeast one-hybrid screening that RFX2 protein specifically binds to this cis element. RFX2 belongs to the RFX DNA-binding protein family, the biological role of which remains obscure. Using an electrophoretic mobility shift assay, we further show that RFX1, RFX2, and RFX3 homodimers and heterodimers specifically bind to the cis element of the IL-5Ralpha promoter. The mRNA expression of RFX1, RFX2, and RFX3 was detected ubiquitously, but in transient-transfection assays, multimerized RFX binding sites in front of a basal promoter efficiently functioned in a tissue- and lineage-specific manner. To further investigate RFX functions on transcription, full-length and deletion mutants of RFX1 were targeted to DNA through fusion to the GAL4 DNA binding domain. Tissue- and lineage-specific transcriptional activation with the full-length RFX1 fusion plasmid on a reporter controlled by GAL4 binding sites was observed. Distinct activation and repression domains within the RFX1 protein were further mapped. Our findings suggest that RFX proteins are transcription factors that contribute to the activity and lineage specificity of the IL-5Ralpha promoter by directly binding to a target cis element and cooperating with other tissue- and lineage-specific cofactors. </p> </div> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" data-ga-category="literature_resources" data-ga-action="disclaimer_link" data-ga-label="under_abstract">PubMed Disclaimer</a> </p> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="fig-1"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/a04db3615be3/mb0691615001.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="408" data-image-height="583" data-image-alt="FIG. 1" data-pmc-id="PMC104353" data-figure-id="F1"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/1150cce81fbe/mb0691615001.gif" alt="FIG. 1" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="408"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="583"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG. 1 </p> </strong> <div class="figure-caption-contents"><p> Binding of RFX2 to the… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG. 1 </p> </strong> <div class="figure-caption-contents"><p> Binding of RFX2 to the <i> cis </i> element of the IL-5Rα promoter in yeast.… </p></div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG. 1 </strong> <div class="figure-caption-contents">Binding of RFX2 to the <i>cis</i> element of the IL-5Rα promoter in yeast. (A) Schematic representation of RFX1 to -5 (7, 28) and three RFX2 clones isolated from yeast one-hybrid screening. The DNA binding domain (DBD), dimerization domain (DIM), conserved regions A, B, and C, and estrogen receptor (ER) regions rich in proline (P), glutamine (Q), or acidic amino acids (DE) are indicated (7, 28). (B) Reporter yeast strains grown on Sabouraud dextrose plates without histidine and with 5 mM 3-amino-1,2,4-triazole at 30°C for 3 days. The reporter strain carrying pHISi-1-IL-5Rα was transformed with pVP16-RFX2 clone 1 (section 1), pVP16 (section 4), and pGAD53m (section 5). At the same time, negative-control reporter strains carrying pHISi-1-C/EBPα (section 2), pHISi-1-p53 (section 3), and pHISi-1 (section 6) were transformed with pVP16-RFX2 clone 1. (C) Binding of RFX2 to the <i>cis</i> element of the IL-5Rα promoter detected by liquid β-galactosidase assay. Bars depict β-galactosidase (β-Gal) reporter gene activity in yeast extracts from the reporter strains. The reporter strain carrying pLacZi-IL-5Rα was transformed with pVP16-RFX2 clone 1, pVP16, and pGAD53m. Negative-control reporter strains carrying pLacZi-C/EBPα, pLacZi-p53, and pLacZi were also transformed with pVP16-RFX2 clone 1. The results are shown as the means ± the standard deviations for three transformants.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="1" data-label-slug="fig-2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/95983ba92162/mb069161502a.jpg" itemprop="contentUrl" aria-describedby="figure-caption-1" role="button" data-image-width="400" data-image-height="202" data-image-alt="FIG. 2" data-pmc-id="PMC104353" data-figure-id="F2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-1" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/711387c556e2/mb069161502a.gif" alt="FIG. 2" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="400"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="202"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG. 2 </p> </strong> <div class="figure-caption-contents"><p> Binding of in vitro-synthesized RFX1,… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG. 2 </p> </strong> <div class="figure-caption-contents"><p> Binding of in vitro-synthesized RFX1, RFX2, and RFX3 to the <i> cis </i> element of… </p></div> </div> <figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG. 2 </strong> <div class="figure-caption-contents">Binding of in vitro-synthesized RFX1, RFX2, and RFX3 to the <i>cis</i> element of the IL-5Rα promoter in EMSA. (A) The probe used in the gel shift assay is the <i>cis</i> element of the IL-5Rα promoter, bp −440 to −411 (37), containing a centrally located RFX binding site (8). The boxes enclose nucleotides that match the consensus sequence. R, Y, and N represent a purine, a pyrimidine, and any nucleotide, respectively. The mutant competitor was designed to contain mutations (in lowercase) of three of the six G residues on which DNA methylation interfered with nuclear factor binding in our previous study (arrows) (38). (B through F) RFX1 (B), RFX2 (C), and RFX3 (D) were individually synthesized in vitro, and RFX1 was cosynthesized with HA-tagged RFX-2 (E) or RFX3 (F); RFX-DNA complexes were analyzed by EMSA. For comparison, RFX-DNA complexes formed with AML14 nuclear extracts (NE) were loaded in the first lanes. The legends above the autoradiographs indicate the source of the in vitro translated protein, competitor, and antibody used. Antibodies 1, 2, 3, H, and p denote antibodies against RFX1, RFX2, RFX3, and HA and preimmune serum, respectively. Positions of free DNA probe (Free), RFX1 homodimers (1/1), RFX2 homodimers (2/2), RFX3 homodimers (3/3), RFX1-RFX2 heterodimers (1/2), RFX1-RFX3 heterodimers (1/3), all supershifted complexes (*), and complexes supershifted by the RFX1 antiserum (S1), the RFX3 antiserum (S3), or the RFX2 antiserum and anti-HA antibody (S2) are indicated.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="2" data-label-slug="fig-2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/d59f0e66f9a2/mb069161502b.jpg" itemprop="contentUrl" aria-describedby="figure-caption-2" role="button" data-image-width="580" data-image-height="720" data-image-alt="FIG. 2" data-pmc-id="PMC104353" data-figure-id="F2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-2" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/711387c556e2/mb069161502a.gif" alt="FIG. 2" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="580"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="720"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG. 2 </p> </strong> <div class="figure-caption-contents"><p> Binding of in vitro-synthesized RFX1,… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG. 2 </p> </strong> <div class="figure-caption-contents"><p> Binding of in vitro-synthesized RFX1, RFX2, and RFX3 to the <i> cis </i> element of… </p></div> </div> <figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG. 2 </strong> <div class="figure-caption-contents">Binding of in vitro-synthesized RFX1, RFX2, and RFX3 to the <i>cis</i> element of the IL-5Rα promoter in EMSA. (A) The probe used in the gel shift assay is the <i>cis</i> element of the IL-5Rα promoter, bp −440 to −411 (37), containing a centrally located RFX binding site (8). The boxes enclose nucleotides that match the consensus sequence. R, Y, and N represent a purine, a pyrimidine, and any nucleotide, respectively. The mutant competitor was designed to contain mutations (in lowercase) of three of the six G residues on which DNA methylation interfered with nuclear factor binding in our previous study (arrows) (38). (B through F) RFX1 (B), RFX2 (C), and RFX3 (D) were individually synthesized in vitro, and RFX1 was cosynthesized with HA-tagged RFX-2 (E) or RFX3 (F); RFX-DNA complexes were analyzed by EMSA. For comparison, RFX-DNA complexes formed with AML14 nuclear extracts (NE) were loaded in the first lanes. The legends above the autoradiographs indicate the source of the in vitro translated protein, competitor, and antibody used. Antibodies 1, 2, 3, H, and p denote antibodies against RFX1, RFX2, RFX3, and HA and preimmune serum, respectively. Positions of free DNA probe (Free), RFX1 homodimers (1/1), RFX2 homodimers (2/2), RFX3 homodimers (3/3), RFX1-RFX2 heterodimers (1/2), RFX1-RFX3 heterodimers (1/3), all supershifted complexes (*), and complexes supershifted by the RFX1 antiserum (S1), the RFX3 antiserum (S3), or the RFX2 antiserum and anti-HA antibody (S2) are indicated.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="3" data-label-slug="fig-3"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/48a1f3c910e3/mb0691615003.jpg" itemprop="contentUrl" aria-describedby="figure-caption-3" role="button" data-image-width="400" data-image-height="390" data-image-alt="FIG. 3" data-pmc-id="PMC104353" data-figure-id="F3"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-3" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/5b89eed48428/mb0691615003.gif" alt="FIG. 3" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="400"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="390"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG. 3 </p> </strong> <div class="figure-caption-contents"><p> Binding of native RFX protein… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG. 3 </p> </strong> <div class="figure-caption-contents"><p> Binding of native RFX protein complexes in a myeloid nuclear extract to the… </p></div> </div> <figcaption id="figure-caption-3" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG. 3 </strong> <div class="figure-caption-contents">Binding of native RFX protein complexes in a myeloid nuclear extract to the <i>cis</i> element of the IL-5Rα promoter in EMSA. RFX-DNA complexes were formed by using an AML14 nuclear extract and were detected by EMSA. The probe and competitors were the same as for Fig. 2. The legends above the autoradiograph indicate the source of competitor and antibody used. Abbreviations are defined in the legend to Fig. 2.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="4" data-label-slug="fig-4"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/f78659dd008b/mb069161504a.jpg" itemprop="contentUrl" aria-describedby="figure-caption-4" role="button" data-image-width="518" data-image-height="594" data-image-alt="FIG. 4" data-pmc-id="PMC104353" data-figure-id="F4"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-4" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/23466b05860a/mb069161504a.gif" alt="FIG. 4" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="518"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="594"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG. 4 </p> </strong> <div class="figure-caption-contents"><p> Expression of RFX1, RFX2, and… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG. 4 </p> </strong> <div class="figure-caption-contents"><p> Expression of RFX1, RFX2, and RFX3 in human cells. (A) Northern blot analysis… </p></div> </div> <figcaption id="figure-caption-4" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG. 4 </strong> <div class="figure-caption-contents">Expression of RFX1, RFX2, and RFX3 in human cells. (A) Northern blot analysis of the mRNA of RFX1, RFX2, and RFX3 in human hematopoietic cells. Total RNAs from human cell lines (15 μg) and primary eosinophils (2 μg) were loaded and probed with cDNA fragments specific for human RFX1, RFX2, RFX3, or GAPDH. (B) Relative expression levels of RFX1, RFX2, and RFX3 in human cell lines and primary eosinophils. The levels of RFX mRNAs in each cell line were normalized to the levels of GAPDH mRNA and then measured relative to the levels in HL-60 cells. Evaluation of mRNA levels are consistent for each gene but cannot be compared among genes. (C) Binding of native RFX complexes in nuclear extracts from various human cell lines to the <i>cis</i> element of the IL-5Rα promoter in EMSA. RFX-DNA complexes were formed in crude nuclear extracts and were detected by EMSA. The probe and competitors were the same as for Fig. 2. Positions of RFX1 homodimers (1/1), homodimers of RFX2 or RFX3 (Homo), heterodimers of RFX1 and RFX2 or RFX3 (Hetero), and complexes supershifted by RFX1 antiserum (S1) are indicated. Free, free DNA probe.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="5" data-label-slug="fig-4"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/6351394376a0/mb069161504c.jpg" itemprop="contentUrl" aria-describedby="figure-caption-5" role="button" data-image-width="400" data-image-height="367" data-image-alt="FIG. 4" data-pmc-id="PMC104353" data-figure-id="F4"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-5" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/23466b05860a/mb069161504a.gif" alt="FIG. 4" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="400"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="367"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG. 4 </p> </strong> <div class="figure-caption-contents"><p> Expression of RFX1, RFX2, and… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG. 4 </p> </strong> <div class="figure-caption-contents"><p> Expression of RFX1, RFX2, and RFX3 in human cells. (A) Northern blot analysis… </p></div> </div> <figcaption id="figure-caption-5" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG. 4 </strong> <div class="figure-caption-contents">Expression of RFX1, RFX2, and RFX3 in human cells. (A) Northern blot analysis of the mRNA of RFX1, RFX2, and RFX3 in human hematopoietic cells. Total RNAs from human cell lines (15 μg) and primary eosinophils (2 μg) were loaded and probed with cDNA fragments specific for human RFX1, RFX2, RFX3, or GAPDH. (B) Relative expression levels of RFX1, RFX2, and RFX3 in human cell lines and primary eosinophils. The levels of RFX mRNAs in each cell line were normalized to the levels of GAPDH mRNA and then measured relative to the levels in HL-60 cells. Evaluation of mRNA levels are consistent for each gene but cannot be compared among genes. (C) Binding of native RFX complexes in nuclear extracts from various human cell lines to the <i>cis</i> element of the IL-5Rα promoter in EMSA. RFX-DNA complexes were formed in crude nuclear extracts and were detected by EMSA. The probe and competitors were the same as for Fig. 2. Positions of RFX1 homodimers (1/1), homodimers of RFX2 or RFX3 (Homo), heterodimers of RFX1 and RFX2 or RFX3 (Hetero), and complexes supershifted by RFX1 antiserum (S1) are indicated. Free, free DNA probe.</div> </figcaption> </figure> <figure class="figure-item tail" itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="6" data-label-slug="fig-5"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/c6e86e36ff4f/mb0691615005.jpg" itemprop="contentUrl" aria-describedby="figure-caption-6" role="button" data-image-width="400" data-image-height="404" data-image-alt="FIG. 5" data-pmc-id="PMC104353" data-figure-id="F5"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-6" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/824f11c47320/mb0691615005.gif" alt="FIG. 5" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="400"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="404"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG. 5 </p> </strong> <div class="figure-caption-contents"><p> Tissue- and lineage-specific enhancer activity… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG. 5 </p> </strong> <div class="figure-caption-contents"><p> Tissue- and lineage-specific enhancer activity of multimerized RFX binding sites. Trimerized RFX binding… </p></div> </div> <figcaption id="figure-caption-6" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG. 5 </strong> <div class="figure-caption-contents">Tissue- and lineage-specific enhancer activity of multimerized RFX binding sites. Trimerized RFX binding sites from the IL-5Rα promoter (bp −434 to −417), containing either wild-type or mutant sequences, were subcloned into the pT81-luc vectors in front of basal thymidine kinase promoters. The reporter plasmids and the parent pT81-luc were transiently transfected into various hematopoietic and nonhematopoietic cell lines. The minimum promoter activity of pT81-luc was approximately 300 RLU, while the background luciferase activity was below 100 RLU in all cells analyzed.</div> </figcaption> </figure> <figure class="figure-item tail" itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="7" data-label-slug="fig-6"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/c3d4d4ecd58d/mb0691615006.jpg" itemprop="contentUrl" aria-describedby="figure-caption-7" role="button" data-image-width="559" data-image-height="816" data-image-alt="FIG. 6" data-pmc-id="PMC104353" data-figure-id="F6"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-7" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/f1c9a614f3b9/mb0691615006.gif" alt="FIG. 6" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="559"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="816"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG. 6 </p> </strong> <div class="figure-caption-contents"><p> Tissue- and lineage-specific transactivation by… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG. 6 </p> </strong> <div class="figure-caption-contents"><p> Tissue- and lineage-specific transactivation by GAL4-RFX1 fusion proteins. (A) Schematic representation of RFX1… </p></div> </div> <figcaption id="figure-caption-7" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG. 6 </strong> <div class="figure-caption-contents">Tissue- and lineage-specific transactivation by GAL4-RFX1 fusion proteins. (A) Schematic representation of RFX1 and its 5′ deletions fused to the GAL4 DNA binding domain (DBD). The numbers correspond to amino acid residues of each domain and the deletion sites (dashed lines). DE, acidic amino acids; DIM, dimerization domain. (B) A reporter plasmid containing multimerized GAL4 binding sites (pHDGAL4 luciferase) or its parent pHD luciferase plasmid was transiently cotransfected with either pcDNA3 containing the GAL4 DNA binding domain only (GAL4) or full-length RFX1 fused to the GAL4 DNA binding domain (GAL4-RFX1Full) into various cell lines. The lowest luciferase activity was obtained in HepG2 (2,360 RLU), while the background luciferase activity was below 100 RLU in all cells analyzed. (C) Mapping of RFX1 regions that activate transcription. A series of 5′ deletion mutants of RFX1 fused to the GAL4 DNA binding domain were cotransfected with the reporter plasmid into U937 and HeLa cells. The minimum promoter activity of pHD luciferase plasmid was 6,053 RLU in U937 cells and 1,556 RLU in HeLa cells, while the background luciferase activity was 42 RLU in U937 cells and 85 RLU in HeLa cells.</div> </figcaption> </figure> <figure class="figure-item tail" itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="8" data-label-slug="fig-7"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/108a270e89e3/mb0691615007.jpg" itemprop="contentUrl" aria-describedby="figure-caption-8" role="button" data-image-width="552" data-image-height="567" data-image-alt="FIG. 7" data-pmc-id="PMC104353" data-figure-id="F7"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-8" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e560/104353/d46524f39357/mb0691615007.gif" alt="FIG. 7" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="552"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="567"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> FIG. 7 </p> </strong> <div class="figure-caption-contents"><p> Localization of the activation and… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> FIG. 7 </p> </strong> <div class="figure-caption-contents"><p> Localization of the activation and inhibitory domains of RFX1. (A) Schematic representation of… </p></div> </div> <figcaption id="figure-caption-8" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> FIG. 7 </strong> <div class="figure-caption-contents">Localization of the activation and inhibitory domains of RFX1. (A) Schematic representation of RFX1 and its 3′ deletions fused to the GAL4 DNA binding domain (DBD). Numbers correspond to amino acid residues of each domain; DIM, dimerization domain; DE, acidic amino acids. (B) A series of 3′ deletion mutants of RFX1 fused to the GAL4 DNA binding domain were cotransfected with the reporter plasmid into U937 and HeLa cells. The minimum promoter activity of pHD luciferase plasmid was 6,053 RLU in U937 cells and 1,556 RLU in HeLa cells, while the background luciferase activity was 42 RLU in U937 cells and 85 RLU in HeLa cells.</div> </figcaption> </figure> </div> <div class="see-all actions-bar"> <button class="show-more" aria-controls="slides-container" data-ga-category="figure" data-ga-action="show_all"> All figures (9) </button> </div>  <div class="pswp figures-dialog" id="figures-dialog" tabindex="-1" role="dialog" aria-hidden="true" data-image-gallery-uid="article-figures" aria-label="Figures Dialog">  <div class="pswp__bg"></div>  <div class="pswp__scroll-wrap">  <div class="pswp__container"> <div class="pswp__item"></div> <div class="pswp__item"></div> <div class="pswp__item"></div> </div>  <div class="pswp__ui pswp__ui--hidden"> <div class="pswp__top-bar">  <div class="pswp__counter"></div> <button class="pswp__button pswp__button--close" title="Close (Esc)"></button> <button class="pswp__button pswp__button--share" title="Share"></button> <button class="pswp__button pswp__button--fs" title="Toggle fullscreen"></button> <button class="pswp__button pswp__button--zoom" title="Zoom in/out"></button>   <div class="pswp__preloader"> <div class="pswp__preloader__icn"> <div class="pswp__preloader__cut"> <div class="pswp__preloader__donut"></div> </div> </div> </div> </div> <div class="pswp__share-modal pswp__share-modal--hidden pswp__single-tap"> <div class="pswp__share-tooltip"></div> </div> <button class="pswp__button pswp__button--arrow--left" title="Previous (arrow left)"> </button> <button class="pswp__button pswp__button--arrow--right" title="Next (arrow right)"> </button> <div class="pswp__caption"> <div class="pswp__caption__center"></div> </div> </div> </div> </div> <div class="figure-dialog-caption"> <div class="figure-caption-link-container"> <a class="figure-caption-link" href="#">See this image and copyright information in PMC</a> </div> <div class="figure-caption-center" data-expand-title="click to show full caption" data-collapse-title="click to hide full caption"> </div> <button class="figure-caption-toggle-btn" aria-label="show full caption" data-expand-text="show full caption" data-collapse-text="hide full caption">  </button> </div> </div> <div class="similar-articles" id="similar"> <h2 class="title"> Similar articles </h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/11682486/" ref="article_id=11682486&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="11682486" data-ga-label=""> Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Morotomi-Yano K, Yano K, Saito H, Sun Z, Iwama A, Miki Y.</span> <span class="docsum-authors short-authors">Morotomi-Yano K, et al.</span> <span class="docsum-journal-citation full-journal-citation">J Biol Chem. 2002 Jan 4;277(1):836-42. doi: 10.1074/jbc.M108638200. 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data-href="/?term=%22Blotting%2C+Northern%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Blotting, Northern"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Blotting, Northern"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Blotting%2C+Northern" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Blotting, Northern"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Blotting, Northern"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Blotting, Northern"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Cells, Cultured" tabindex="0" aria-controls="keyword-actions-mesh-terms-2" aria-expanded="false" data-pinger-ignore> Cells, Cultured </button><div id="keyword-actions-mesh-terms-2" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Cells, Cultured"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Cells%2C+Cultured%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Cells%2C+Cultured%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Cells, Cultured"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Cells, Cultured"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Cells%2C+Cultured" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Cells, Cultured"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Cells, Cultured"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Cells, Cultured"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword DNA-Binding Proteins / genetics*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-3" aria-expanded="false" data-pinger-ignore> DNA-Binding Proteins / genetics* </button><div id="keyword-actions-mesh-terms-major-3" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword DNA-Binding Proteins / genetics*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22DNA-Binding+Proteins%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22DNA-Binding+Proteins%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="DNA-Binding Proteins/genetics"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="DNA-Binding Proteins / genetics*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=DNA-Binding+Proteins" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="DNA-Binding Proteins / genetics*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""DNA-Binding Proteins/genetics"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""DNA-Binding Proteins/genetics"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Electrophoresis, Polyacrylamide Gel" tabindex="0" aria-controls="keyword-actions-mesh-terms-4" aria-expanded="false" data-pinger-ignore> Electrophoresis, Polyacrylamide Gel </button><div id="keyword-actions-mesh-terms-4" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Electrophoresis, Polyacrylamide Gel"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Electrophoresis%2C+Polyacrylamide+Gel%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Electrophoresis%2C+Polyacrylamide+Gel%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Electrophoresis, Polyacrylamide Gel"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Electrophoresis, Polyacrylamide Gel"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Electrophoresis%2C+Polyacrylamide+Gel" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Electrophoresis, Polyacrylamide Gel"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Electrophoresis, Polyacrylamide Gel"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Electrophoresis, Polyacrylamide Gel"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Gene Deletion" tabindex="0" aria-controls="keyword-actions-mesh-terms-5" aria-expanded="false" data-pinger-ignore> Gene Deletion </button><div id="keyword-actions-mesh-terms-5" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Gene Deletion"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Gene+Deletion%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Gene+Deletion%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Gene Deletion"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Gene Deletion"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Gene+Deletion" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Gene Deletion"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Gene Deletion"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Gene Deletion"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Genes, Reporter" tabindex="0" aria-controls="keyword-actions-mesh-terms-6" aria-expanded="false" data-pinger-ignore> Genes, Reporter </button><div id="keyword-actions-mesh-terms-6" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Genes, Reporter"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Genes%2C+Reporter%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Genes%2C+Reporter%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Genes, Reporter"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Genes, Reporter"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Genes%2C+Reporter" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Genes, Reporter"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Genes, Reporter"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Genes, Reporter"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword HL-60 Cells" tabindex="0" aria-controls="keyword-actions-mesh-terms-7" aria-expanded="false" data-pinger-ignore> HL-60 Cells </button><div id="keyword-actions-mesh-terms-7" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword HL-60 Cells"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22HL-60+Cells%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22HL-60+Cells%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="HL-60 Cells"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="HL-60 Cells"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=HL-60+Cells" data-ga-category="search_mesh" 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href="/?term=%22HeLa+Cells%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22HeLa+Cells%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="HeLa Cells"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="HeLa Cells"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=HeLa+Cells" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="HeLa Cells"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""HeLa Cells"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""HeLa Cells"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Humans" tabindex="0" aria-controls="keyword-actions-mesh-terms-9" aria-expanded="false" data-pinger-ignore> Humans </button><div id="keyword-actions-mesh-terms-9" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Humans"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Humans"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Humans"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Humans" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Humans"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Humans"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Humans"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Models, Genetic" tabindex="0" aria-controls="keyword-actions-mesh-terms-10" aria-expanded="false" data-pinger-ignore> Models, Genetic </button><div id="keyword-actions-mesh-terms-10" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Models, Genetic"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Models%2C+Genetic%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Models%2C+Genetic%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Models, Genetic"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Models, Genetic"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Models%2C+Genetic" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Models, Genetic"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Models, Genetic"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Models, Genetic"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Multigene Family*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-11" aria-expanded="false" data-pinger-ignore> Multigene Family* </button><div id="keyword-actions-mesh-terms-major-11" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Multigene Family*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Multigene+Family%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Multigene+Family%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Multigene Family"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Multigene Family*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Multigene+Family" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Multigene Family*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Multigene Family"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Multigene Family"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Plasmids" tabindex="0" aria-controls="keyword-actions-mesh-terms-12" aria-expanded="false" data-pinger-ignore> Plasmids </button><div id="keyword-actions-mesh-terms-12" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Plasmids"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Plasmids%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Plasmids%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Plasmids"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Plasmids"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Plasmids" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Plasmids"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Plasmids"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Plasmids"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Point Mutation" tabindex="0" aria-controls="keyword-actions-mesh-terms-13" aria-expanded="false" data-pinger-ignore> Point Mutation </button><div id="keyword-actions-mesh-terms-13" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Point Mutation"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Point+Mutation%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Point+Mutation%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Point Mutation"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Point Mutation"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Point+Mutation" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Point Mutation"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Point Mutation"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Point Mutation"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Promoter Regions, Genetic*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-14" aria-expanded="false" data-pinger-ignore> Promoter Regions, Genetic* </button><div id="keyword-actions-mesh-terms-major-14" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Promoter Regions, Genetic*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Promoter+Regions%2C+Genetic%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Promoter+Regions%2C+Genetic%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Promoter Regions, Genetic"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Promoter Regions, Genetic*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Promoter+Regions%2C+Genetic" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Promoter Regions, Genetic*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Promoter Regions, Genetic"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Promoter Regions, Genetic"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Protein Binding" tabindex="0" aria-controls="keyword-actions-mesh-terms-15" aria-expanded="false" data-pinger-ignore> Protein Binding </button><div id="keyword-actions-mesh-terms-15" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Protein Binding"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Protein+Binding%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Protein+Binding%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Protein Binding"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Protein Binding"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Protein+Binding" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Protein Binding"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Protein Binding"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Protein Binding"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Receptors, Interleukin / genetics*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-16" aria-expanded="false" data-pinger-ignore> Receptors, Interleukin / genetics* </button><div id="keyword-actions-mesh-terms-major-16" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Receptors, Interleukin / genetics*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Receptors%2C+Interleukin%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Receptors%2C+Interleukin%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Receptors, Interleukin/genetics"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Receptors, Interleukin / genetics*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Receptors%2C+Interleukin" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Receptors, Interleukin / genetics*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Receptors, Interleukin/genetics"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Receptors, Interleukin/genetics"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Receptors, Interleukin-5" tabindex="0" aria-controls="keyword-actions-mesh-terms-17" aria-expanded="false" data-pinger-ignore> Receptors, Interleukin-5 </button><div id="keyword-actions-mesh-terms-17" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Receptors, Interleukin-5"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Receptors%2C+Interleukin-5%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Receptors%2C+Interleukin-5%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Receptors, Interleukin-5"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Receptors, Interleukin-5"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Receptors%2C+Interleukin-5" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Receptors, Interleukin-5"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Receptors, Interleukin-5"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Receptors, Interleukin-5"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div 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dropdown-block-link" href="/?term=%22Repressor+Proteins%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Repressor+Proteins%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Repressor Proteins"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Repressor Proteins"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Repressor+Proteins" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Repressor Proteins"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Repressor Proteins"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Repressor Proteins"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Sequence Homology, Nucleic Acid" tabindex="0" aria-controls="keyword-actions-mesh-terms-21" aria-expanded="false" data-pinger-ignore> Sequence Homology, Nucleic Acid </button><div id="keyword-actions-mesh-terms-21" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Sequence Homology, Nucleic Acid"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Sequence+Homology%2C+Nucleic+Acid%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Sequence+Homology%2C+Nucleic+Acid%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Sequence Homology, Nucleic Acid"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Sequence Homology, Nucleic Acid"> 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genetics*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Transcription Factors/genetics"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Transcription Factors/genetics"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="substances" class="substances keywords-section"> <h2 class="title"> Substances </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword DNA-Binding Proteins" tabindex="0" aria-controls="keyword-actions-substances-0" aria-expanded="false" data-pinger-ignore> DNA-Binding Proteins </button><div id="keyword-actions-substances-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword DNA-Binding Proteins"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22DNA-Binding+Proteins%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22DNA-Binding+Proteins%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="DNA-Binding Proteins"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="DNA-Binding Proteins"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22DNA-Binding+Proteins%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="DNA-Binding Proteins"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""DNA-Binding Proteins"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""DNA-Binding Proteins"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword RFX1 protein, human" tabindex="0" aria-controls="keyword-actions-substances-1" aria-expanded="false" data-pinger-ignore> RFX1 protein, human </button><div id="keyword-actions-substances-1" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword RFX1 protein, human"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22RFX1+protein%2C+human%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22RFX1+protein%2C+human%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="RFX1 protein, human"[nm]" data-ga-category="search" 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ref="linksrc=add_to_search_link" role="button" data-search-term=""RFX2 protein, human"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""RFX2 protein, human"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword RFX3 protein, human" tabindex="0" aria-controls="keyword-actions-substances-3" aria-expanded="false" data-pinger-ignore> RFX3 protein, human </button><div id="keyword-actions-substances-3" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword RFX3 protein, human"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22RFX3+protein%2C+human%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22RFX3+protein%2C+human%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="RFX3 protein, human"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="RFX3 protein, human"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22RFX3+protein%2C+human%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="RFX3 protein, human"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""RFX3 protein, human"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""RFX3 protein, human"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Receptors, Interleukin" tabindex="0" aria-controls="keyword-actions-substances-4" aria-expanded="false" data-pinger-ignore> Receptors, Interleukin </button><div id="keyword-actions-substances-4" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Receptors, Interleukin"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Receptors%2C+Interleukin%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Receptors%2C+Interleukin%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Receptors, Interleukin"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Receptors, Interleukin"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Receptors%2C+Interleukin%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Receptors, Interleukin"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Receptors, Interleukin"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Receptors, Interleukin"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Receptors, Interleukin-5" tabindex="0" aria-controls="keyword-actions-substances-5" aria-expanded="false" data-pinger-ignore> Receptors, Interleukin-5 </button><div id="keyword-actions-substances-5" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Receptors, Interleukin-5"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Receptors%2C+Interleukin-5%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Receptors%2C+Interleukin-5%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Receptors, Interleukin-5"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Receptors, Interleukin-5"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Receptors%2C+Interleukin-5%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Receptors, Interleukin-5"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Receptors, Interleukin-5"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Receptors, Interleukin-5"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Regulatory Factor X Transcription Factors" tabindex="0" aria-controls="keyword-actions-substances-6" aria-expanded="false" data-pinger-ignore> Regulatory Factor X Transcription Factors </button><div id="keyword-actions-substances-6" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Regulatory Factor X Transcription Factors"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Regulatory+Factor+X+Transcription+Factors%22%5Bnm%5D&sort=date&sort_order=desc" 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Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains - PubMed