CINXE.COM
Published guidance, NICE advice and quality standards | Guidance | NICE
<!DOCTYPE html><html lang="en-GB" prefix="og: http://ogp.me/ns#"><head><meta charSet="utf-8"/><meta name="twitter:card" content="summary"/><meta name="twitter:site" content="@NICEComms"/><meta name="twitter:creator" content="@NICEComms"/><meta property="og:url" content="https://www.nice.org.uk/guidance/published"/><meta property="og:type" content="website"/><meta property="og:image" content="/open-graph/open-graph-1200x630.png"/><meta property="og:image:alt" content="Logo for NICE (The National Institute for Health and Care Excellence)"/><meta property="og:image:width" content="1200"/><meta property="og:image:height" content="630"/><meta property="og:image" content="/open-graph/open-graph-1200x1200.png"/><meta property="og:image:alt" content="Logo for NICE (The National Institute for Health and Care Excellence)"/><meta property="og:image:width" content="1200"/><meta property="og:image:height" content="1200"/><meta property="og:locale" content="en_GB"/><meta property="og:site_name" content="NICE website: The National Institute for Health and Care Excellence"/><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"/><meta name="application-name" content="NICE"/><meta name="DC:Publisher" content="NICE"/><meta name="DC.Rights.Copyright" content="All content on this site is NICE copyright unless otherwise stated. You can download material for private research, study or in-house use only. Do not distribute or publish any material from this site without first obtaining NICE's permission. Where Crown copyright applies, see the Office of Public Sector Information (formerly HMSO) website for information."/><meta name="DC.Language" content="eng"/><meta name="x-country" content="gb"/><meta name="apple-mobile-web-app-capable" content="yes"/><meta name="apple-mobile-web-app-title" content="NICE"/><meta name="theme-color" content="#004650"/><meta name="msapplication-TileColor" content="#004650"/><meta http-equiv="x-ua-compatible" content="IE=edge; chrome=1"/><link rel="icon" href="/favicon.ico"/><link rel="icon" type="image/png" sizes="16x16" href="/icons/icon-16x16.png"/><link rel="icon" type="image/png" sizes="32x32" href="/icons/icon-32x32.png"/><link rel="apple-touch-icon" sizes="120x120" href="/icons/icon-120x120.png"/><link rel="apple-touch-icon" sizes="152x152" href="/icons/icon-152x152.png"/><link rel="apple-touch-icon" sizes="167x167" href="/icons/icon-167x167.png"/><link rel="apple-touch-icon" sizes="180x180" href="/icons/icon-180x180.png"/><link rel="mask-icon" color="black" href="/icons/safari-pinned-tab.svg"/><link rel="canonical" href="https://www.nice.org.uk/guidance/published"/><title>Published guidance, NICE advice and quality standards | Guidance | NICE</title><meta name="robots" content="index,follow"/><meta name="description" content="Browse the complete list of all our published health and social care guidance, including guidelines, NICE advice and quality standards"/><meta property="og:title" content="Published guidance, NICE advice and quality standards | Guidance | NICE"/><meta property="og:description" content="Browse the complete list of all our published health and social care guidance, including guidelines, NICE advice and quality standards"/><meta name="next-head-count" content="41"/><link rel="preload" href="/_next/static/media/a34f9d1faa5f3315-s.p.woff2" as="font" type="font/woff2" crossorigin="anonymous" data-next-font="size-adjust"/><link rel="preload" href="/_next/static/media/3a8dc5763a8ae4b2-s.p.woff2" as="font" type="font/woff2" crossorigin="anonymous" data-next-font="size-adjust"/><link rel="preload" href="/_next/static/css/8c329cb8c6555bb3.css" as="style"/><link rel="stylesheet" href="/_next/static/css/8c329cb8c6555bb3.css" data-n-g=""/><link rel="preload" href="/_next/static/css/e34a671e3f3c1cf0.css" as="style"/><link rel="stylesheet" href="/_next/static/css/e34a671e3f3c1cf0.css" data-n-p=""/><noscript data-n-css=""></noscript><script defer="" nomodule="" src="/_next/static/chunks/polyfills-c67a75d1b6f99dc8.js"></script><script id="cookieBanner" src="https://cdn.nice.org.uk/cookie-banner/cookie-banner.min.js" defer="" data-nscript="beforeInteractive"></script><script src="/_next/static/chunks/webpack-a8152f522ffbca5f.js" defer=""></script><script src="/_next/static/chunks/framework-ca706bf673a13738.js" defer=""></script><script src="/_next/static/chunks/main-ea26e5a44792708e.js" defer=""></script><script src="/_next/static/chunks/pages/_app-beadde1d6848e8e5.js" defer=""></script><script src="/_next/static/chunks/1664-e3df72ec02461a64.js" defer=""></script><script src="/_next/static/chunks/253-d394043e4327133d.js" defer=""></script><script src="/_next/static/chunks/5663-0fe148b2a1ae1418.js" defer=""></script><script src="/_next/static/chunks/3550-d5f1386f93d425c2.js" defer=""></script><script src="/_next/static/chunks/6606-15d62259b3486e5d.js" defer=""></script><script src="/_next/static/chunks/pages/guidance/published-ee12a053ce5ba499.js" defer=""></script><script src="/_next/static/nPtE9ZhzdAiprqYEkzKqu/_buildManifest.js" defer=""></script><script src="/_next/static/nPtE9ZhzdAiprqYEkzKqu/_ssgManifest.js" defer=""></script></head><body><div id="__next"><div class="__variable_d48d41 __variable_d65c78"><div><span id="scrim" aria-hidden="true"></span><div class="Header_header__xWXlb" data-tracking="Global nav" id="top"><header aria-label="Site header"><ul class="Header_a11yLinks__8L7qW" aria-label="Accessibility links"><li><a href="#content-start" class="SkipLink_link__RWkQR">Skip to content</a></li><li><a href="https://www.nice.org.uk/accessibility" class="SkipLink_link__RWkQR">Accessibility help</a></li></ul><div class="Header_container__ptUfU"><a href="https://www.nice.org.uk/" aria-label="Home" class="Header_home__QrJHW" data-tracking="Logo"><svg viewBox="0 0 4411 512" fill="none" xmlns="http://www.w3.org/2000/svg" class="Header_icon__2lJSt" aria-hidden="true" focusable="false"><path d="M395.255 39.65v434.318h-79.301l-188.91-273.361h-3.237v273.361H32V39.65h80.625l187.439 273.214h3.826V39.65h91.365ZM550.032 39.65h-91.807v434.318h91.807V39.65ZM996.266 191.779h-92.837c-1.765-12.064-5.149-22.657-10.446-32.073-5.296-9.416-11.917-17.361-20.156-24.129-8.239-6.621-17.655-11.77-28.248-15.301-10.741-3.531-22.216-5.297-34.722-5.297-22.511 0-42.078 5.591-58.704 16.626-16.625 11.034-29.572 27.218-38.841 48.404-9.122 21.186-13.83 46.786-13.83 76.947s4.561 56.938 13.83 77.977 22.216 36.929 38.841 47.669c16.626 10.74 36.046 16.037 57.968 16.037 12.359 0 23.688-1.618 34.281-4.855s19.862-7.945 28.101-14.271c8.239-6.327 15.007-13.977 20.45-22.952 5.444-8.975 9.269-19.421 11.329-30.897l92.837.442c-2.354 19.862-8.386 39.135-17.95 57.526-9.563 18.391-22.363 34.869-38.4 49.435-16.036 14.418-35.163 25.894-57.232 34.28-22.069 8.386-47.08 12.653-75.034 12.653-38.694 0-73.269-8.828-103.724-26.336s-54.437-42.961-72.092-76.064c-17.655-33.251-26.483-73.416-26.483-120.644 0-47.227 8.975-87.687 26.777-120.938 17.802-33.25 41.931-58.556 72.533-76.064 30.603-17.508 64.883-26.189 102.989-26.189 25.158 0 48.552 3.532 70.032 10.594 21.628 7.062 40.754 17.36 57.379 30.896 16.626 13.536 30.308 30.014 40.754 49.582 10.593 19.568 17.214 41.784 20.304 66.942M1049.53 473.968V39.65h292.63v75.771h-200.83V218.85h185.82v75.771h-185.82v103.724h201.71v75.623h-293.51ZM1599.34 168.68h-1.62l-89.6-128.882h-19.13v163.751h19.87V74.961h1.47l89.3 128.588h19.13V39.798h-19.42V168.68ZM1726.31 127.779c-2.21 1.177-5.59 2.06-10.3 2.649-4.71.441-10.74 1.177-18.25 2.207-5.73.735-11.32 1.765-17.06 2.942-5.59 1.324-10.74 3.09-15.45 5.591-4.71 2.501-8.39 5.885-11.18 10.299-2.8 4.413-4.12 10.151-4.12 17.213 0 7.945 1.91 14.86 5.59 20.451 3.68 5.591 8.83 9.858 15.15 12.8 6.33 2.943 13.39 4.414 21.19 4.414 7.21 0 13.24-1.03 18.1-3.237 5-2.06 8.97-4.708 11.91-7.798 2.95-3.089 5.15-5.885 6.33-8.533h1.03v16.625h18.83V122.63c0-9.71-1.62-17.508-4.85-23.393-3.24-5.885-7.21-10.152-12.07-13.094-4.85-2.943-9.85-4.856-15-5.738-5.15-.883-9.71-1.472-13.69-1.472-6.18 0-12.5.883-18.83 2.501-6.33 1.619-12.21 4.561-17.51 8.828-5.29 4.12-9.71 10.005-12.8 17.508l17.95 6.327c2.06-4.414 5.74-8.681 10.74-12.653 5.15-3.973 12.21-5.885 21.19-5.885 8.97 0 15.15 2.207 19.42 6.62 4.27 4.414 6.47 10.446 6.47 18.391v.589c0 3.089-1.03 5.149-3.23 6.326l.44.294Zm3.23 31.338c0 5.15-1.32 10.005-3.97 14.566-2.65 4.708-6.47 8.386-11.62 11.329-5.15 2.942-11.48 4.413-18.98 4.413s-13.68-1.618-18.54-5.002c-4.85-3.384-7.35-8.239-7.35-14.86 0-4.855 1.32-8.533 3.82-11.328 2.65-2.796 6.03-4.856 10.3-6.327 4.27-1.471 8.83-2.501 13.68-3.09 2.06-.294 4.71-.588 7.95-1.029 3.23-.442 6.62-.883 10.15-1.472 3.53-.588 6.62-1.177 9.27-2.06 2.65-.735 4.41-1.618 5.29-2.648v17.508ZM1791.19 173.536c0 7.209 1.62 13.094 5 17.802 3.39 4.708 7.51 8.239 12.66 10.446 5.15 2.207 10.3 3.384 15.59 3.384 3.53 0 6.48-.294 8.68-.736 2.21-.441 4.12-1.03 5.3-1.471l-3.83-16.92c-.73.147-1.91.295-3.23.589-1.33.294-3.09.294-5.15.294-2.8 0-5.45-.441-7.8-1.324-2.5-.883-4.56-2.648-6.03-5.297-1.62-2.648-2.36-6.62-2.36-11.917v-71.65h26.19V80.699h-26.19V51.274h-18.83v29.425h-18.54v16.037h18.54v76.8ZM1883.59 80.699h-18.84v122.85h18.84V80.699ZM1874.32 34.648c-3.68 0-6.77 1.324-9.42 3.825-2.65 2.502-3.97 5.591-3.97 8.975 0 3.384 1.32 6.474 3.97 8.975 2.65 2.501 5.74 3.825 9.42 3.825 3.68 0 6.77-1.177 9.41-3.825 2.65-2.648 3.98-5.59 3.98-8.975 0-3.384-1.33-6.473-3.98-8.974-2.64-2.502-5.73-3.826-9.41-3.826ZM1997.17 87.025c-8.39-5.296-18.1-7.945-29.13-7.945-11.04 0-20.75 2.649-29.13 7.945-8.39 5.297-14.86 12.653-19.57 22.216-4.71 9.564-7.06 20.745-7.06 33.545s2.35 23.835 7.06 33.251c4.71 9.563 11.18 16.919 19.57 22.216 8.38 5.296 18.09 7.945 29.13 7.945 11.03 0 20.74-2.649 29.13-7.945 8.38-5.297 14.86-12.653 19.57-22.216 4.7-9.563 7.06-20.598 7.06-33.251 0-12.653-2.36-23.981-7.06-33.545-4.71-9.563-11.19-16.92-19.57-22.216Zm3.68 78.566c-2.65 7.062-6.62 12.653-12.07 17.066-5.44 4.267-12.36 6.474-20.74 6.474-8.39 0-15.3-2.207-20.75-6.474-5.44-4.266-9.41-10.004-12.06-17.066-2.65-7.062-3.97-14.713-3.97-22.805s1.32-15.889 3.97-22.952c2.65-7.062 6.62-12.8 12.06-17.213 5.45-4.414 12.36-6.621 20.75-6.621 8.38 0 15.3 2.207 20.74 6.621 5.45 4.413 9.42 10.151 12.07 17.213 2.64 7.063 3.97 14.713 3.97 22.952 0 8.239-1.33 15.89-3.97 22.805ZM2130.02 84.23c-6.18-3.384-13.53-5.002-21.77-5.002-9.27 0-16.77 1.912-22.66 5.738-5.88 3.825-10.3 8.827-13.09 15.154h-1.62V80.846h-18.24V203.55h18.83v-73.858c0-7.209 1.32-13.241 4.12-18.244 2.65-5.002 6.47-8.827 11.18-11.475 4.71-2.649 10-3.973 16.04-3.973 8.68 0 15.59 2.648 20.59 8.092 5.01 5.444 7.51 12.947 7.51 22.658v76.8h18.83v-77.977c0-10.446-1.77-19.127-5.15-25.895-3.53-6.915-8.24-11.917-14.57-15.3v-.148ZM2256.99 186.924h1.03v16.625h18.84V122.63c0-9.71-1.62-17.508-4.86-23.393-3.24-5.885-7.21-10.152-12.06-13.094-4.86-2.943-9.86-4.856-15.01-5.738-5.15-.883-9.71-1.472-13.68-1.472-6.18 0-12.51.883-18.83 2.501-6.33 1.619-12.22 4.561-17.51 8.828-5.3 4.12-9.71 10.005-12.8 17.508l17.95 6.327c2.06-4.414 5.73-8.681 10.74-12.653 5.15-3.973 12.21-5.885 21.18-5.885 8.98 0 15.16 2.207 19.42 6.62 4.27 4.414 6.48 10.446 6.48 18.391v.589c0 3.089-1.03 5.149-3.24 6.326-2.21 1.177-5.59 2.06-10.3 2.648-4.71.442-10.74 1.177-18.24 2.207-5.74.736-11.33 1.766-17.07 2.943-5.59 1.324-10.74 3.089-15.45 5.591-4.7 2.501-8.38 5.885-11.18 10.298-2.79 4.414-4.12 10.152-4.12 17.214 0 7.945 1.91 14.86 5.59 20.451 3.68 5.591 8.83 9.857 15.16 12.8 6.32 2.942 13.39 4.414 21.18 4.414 7.21 0 13.24-1.03 18.1-3.237 5-2.06 8.97-4.708 11.92-7.798 2.94-3.09 5.15-5.885 6.32-8.533l.44.441Zm-14.71-1.912c-5.15 2.942-11.47 4.413-18.98 4.413-7.5 0-13.68-1.618-18.54-5.002-4.85-3.384-7.35-8.239-7.35-14.86 0-4.855 1.32-8.533 3.82-11.328 2.65-2.796 6.04-4.856 10.3-6.327 4.27-1.471 8.83-2.501 13.69-3.09 2.06-.294 4.7-.588 7.94-1.029 3.24-.442 6.62-.883 10.15-1.472 3.53-.588 6.62-1.177 9.27-2.06 2.65-.735 4.41-1.618 5.3-2.648v17.214c0 5.149-1.33 10.005-3.97 14.566-2.65 4.708-6.48 8.386-11.63 11.328v.295ZM2330.11 39.798h-18.83v163.751h18.83V39.798ZM2450.46 39.798h-19.86v163.751h19.86V39.798ZM2506.37 129.692c0-7.209 1.33-13.241 4.12-18.244 2.65-5.002 6.47-8.827 11.18-11.476 4.71-2.648 10.01-3.972 16.04-3.972 8.68 0 15.59 2.648 20.6 8.092 5 5.444 7.5 12.947 7.5 22.657v76.8h18.83v-77.977c0-10.446-1.76-19.126-5.15-25.894-3.53-6.915-8.24-11.917-14.56-15.301-6.18-3.384-13.54-5.002-21.78-5.002-9.27 0-16.77 1.912-22.65 5.738-5.89 3.825-10.3 8.827-13.1 15.154h-1.62V80.993h-18.24V203.55h18.83v-73.857ZM2700.43 148.23c-5.44-5.444-13.53-9.563-24.57-12.212l-18.24-4.413c-7.21-1.766-12.66-4.12-16.04-6.768-3.38-2.648-5.15-6.474-5.15-11.182 0-5.296 2.5-9.71 7.51-13.094 5-3.384 11.18-5.15 18.68-5.15 5.44 0 10 .883 13.54 2.649 3.53 1.765 6.32 3.972 8.38 6.62 2.06 2.649 3.68 5.444 4.71 8.24l16.92-4.856c-2.94-8.68-7.8-15.742-14.86-21.186-6.92-5.296-16.48-7.945-28.69-7.945-8.68 0-16.33 1.472-23.1 4.561-6.77 3.09-12.21 7.21-16.04 12.506-3.82 5.297-5.88 11.476-5.88 18.391 0 8.533 2.65 15.595 7.94 21.186 5.3 5.591 13.54 9.71 24.72 12.359l20.45 4.855c6.18 1.471 10.74 3.678 13.68 6.473 2.95 2.943 4.42 6.474 4.42 10.741 0 5.296-2.65 9.857-7.8 13.535-5.15 3.678-12.21 5.591-21.04 5.591-7.8 0-13.98-1.618-18.68-5.002-4.71-3.384-7.95-8.239-9.71-14.86l-17.95 4.414c2.2 10.446 7.35 18.391 15.59 23.834 8.24 5.444 18.54 8.092 31.05 8.092 9.56 0 17.95-1.618 25.15-4.855 7.21-3.237 12.8-7.651 16.78-13.094 3.97-5.591 6.03-11.77 6.03-18.832 0-8.534-2.65-15.596-8.09-21.039l.29.441ZM2745.31 173.536c0 7.209 1.62 13.094 5 17.802s7.5 8.239 12.65 10.446c5.15 2.207 10.3 3.384 15.6 3.384 3.53 0 6.47-.294 8.68-.736 2.21-.441 4.12-1.03 5.3-1.471l-3.83-16.92c-.74.147-1.91.295-3.24.589-1.32.294-3.09.294-5.15.294-2.79 0-5.44-.441-7.79-1.324-2.51-.883-4.56-2.648-6.04-5.297-1.61-2.648-2.35-6.62-2.35-11.917v-71.65h26.19V80.699h-26.19V51.274h-18.83v29.425h-18.54v16.037h18.54v76.8ZM2828.43 34.648c-3.67 0-6.76 1.324-9.41 3.825-2.65 2.502-3.97 5.591-3.97 8.975 0 3.384 1.32 6.474 3.97 8.975 2.65 2.501 5.74 3.825 9.41 3.825 3.68 0 6.77-1.177 9.42-3.825 2.65-2.648 3.97-5.59 3.97-8.975 0-3.384-1.32-6.473-3.97-8.974-2.65-2.502-5.74-3.826-9.42-3.826ZM2837.7 80.699h-18.83v122.85h18.83V80.699ZM2880.66 173.536c0 7.209 1.62 13.094 5.01 17.802 3.38 4.708 7.5 8.239 12.65 10.446 5.15 2.207 10.3 3.384 15.59 3.384 3.54 0 6.48-.294 8.68-.736 2.21-.441 4.12-1.03 5.3-1.471l-3.82-16.92c-.74.147-1.92.295-3.24.589-1.33.294-3.09.294-5.15.294-2.8 0-5.44-.441-7.8-1.324-2.5-.883-4.56-2.648-6.03-5.297-1.62-2.648-2.35-6.62-2.35-11.917v-71.65h26.18V80.699h-26.18V51.274h-18.84v29.425h-18.53v16.037h18.53v76.8ZM3030.29 182.805h1.33v20.744h18.83V80.699h-18.83v72.68c0 7.651-1.62 13.977-5.01 18.98-3.38 5.002-7.5 8.68-12.36 11.034-4.85 2.354-9.71 3.678-14.41 3.678-7.8 0-14.28-2.648-19.28-7.945-5-5.296-7.5-12.505-7.5-21.48V80.699h-18.83v77.977c0 10.446 1.76 19.126 5.15 25.894 3.38 6.915 8.09 11.917 14.12 15.301 6.03 3.384 12.8 5.15 20.45 5.15 9.27 0 16.92-2.207 23.1-6.474 6.03-4.267 10.59-9.71 13.39-15.89l-.15.148ZM3093.26 173.536c0 7.209 1.62 13.094 5 17.802 3.39 4.708 7.51 8.239 12.66 10.446 5.15 2.207 10.29 3.384 15.59 3.384 3.53 0 6.47-.294 8.68-.736 2.21-.441 4.12-1.03 5.3-1.471l-3.83-16.92c-.73.147-1.91.295-3.23.589-1.33.294-3.09.294-5.15.294-2.8 0-5.45-.441-7.8-1.324-2.5-.883-4.56-2.648-6.03-5.297-1.62-2.648-2.36-6.62-2.36-11.917v-71.65h26.19V80.699h-26.19V51.274h-18.83v29.425h-18.54v16.037h18.54v76.8ZM3251.13 92.763c-5.15-4.708-10.74-8.239-17.07-10.299-6.33-2.06-12.5-3.236-18.98-3.236-11.03 0-20.74 2.648-28.98 8.092-8.24 5.443-14.71 12.947-19.42 22.51-4.71 9.563-6.92 20.745-6.92 33.251 0 12.505 2.36 23.54 6.92 33.103 4.56 9.563 11.18 16.772 19.71 22.069 8.54 5.297 18.69 7.798 30.6 7.798 8.24 0 15.75-1.324 22.51-3.826 6.63-2.648 12.22-6.179 16.78-10.887 4.56-4.708 7.79-10.152 9.71-16.331l-18.25-5.149c-1.61 4.266-3.82 7.797-6.76 10.74-2.95 2.942-6.48 5.002-10.45 6.326-3.97 1.472-8.53 2.06-13.54 2.06-7.65 0-14.27-1.618-20.01-5.002-5.73-3.384-10.29-8.239-13.53-14.566-2.94-5.738-4.27-12.947-4.56-21.039h89.01v-7.945c0-11.476-1.47-21.186-4.56-28.984-3.09-7.797-7.06-14.124-12.21-18.979v.294Zm-72.09 39.577c.29-5.738 1.61-11.034 4.12-16.184 2.94-5.885 7.06-10.74 12.65-14.418 5.44-3.678 11.92-5.59 19.42-5.59 6.77 0 12.8 1.618 17.8 4.707 5 3.09 8.98 7.504 11.62 12.947 2.8 5.444 4.12 11.623 4.12 18.538h-69.73ZM3414.73 96.736V80.699h-27.51V68.193c0-6.032 1.32-10.74 4.12-13.83s7.21-4.708 13.54-4.708c2.64 0 4.85.294 6.62.736 1.76.441 2.94.883 3.97 1.177l5.44-16.331c-1.47-.589-3.68-1.324-6.62-2.06S3407.52 32 3402.96 32c-5.88 0-11.47 1.177-16.77 3.531-5.3 2.354-9.56 5.885-12.95 10.593-3.23 4.708-5 10.593-5 17.655V80.7h-19.86v16.037h19.86v106.813h18.83V96.736h27.66ZM3534.79 176.037c4.7-9.563 7.06-20.598 7.06-33.251 0-12.653-2.36-23.981-7.06-33.545-4.71-9.563-11.19-16.92-19.57-22.216-8.39-5.296-18.1-7.945-29.13-7.945-11.04 0-20.75 2.649-29.13 7.945-8.39 5.297-14.86 12.653-19.57 22.216-4.71 9.564-7.06 20.745-7.06 33.545s2.35 23.835 7.06 33.251c4.71 9.563 11.18 16.919 19.57 22.216 8.38 5.296 18.09 7.945 29.13 7.945 11.03 0 20.74-2.649 29.13-7.945 8.38-5.297 14.86-12.653 19.57-22.216Zm-15.75-10.446c-2.65 7.062-6.62 12.653-12.06 17.066-5.44 4.267-12.36 6.474-20.75 6.474-8.38 0-15.3-2.207-20.74-6.474-5.44-4.266-9.42-10.004-12.07-17.066-2.64-7.062-3.97-14.713-3.97-22.805s1.33-15.889 3.97-22.952c2.65-7.062 6.63-12.8 12.07-17.213 5.44-4.414 12.36-6.621 20.74-6.621 8.39 0 15.31 2.207 20.75 6.621 5.44 4.413 9.41 10.151 12.06 17.213 2.65 7.063 3.98 14.713 3.98 22.952 0 8.239-1.33 15.89-3.98 22.805ZM3622.03 78.786c-7.35 0-13.98 1.913-19.86 5.738-5.89 3.825-9.86 8.68-12.21 14.86h-1.33V80.846h-18.24v122.703h18.83v-77.682c0-5.591 1.33-10.446 3.98-14.86 2.64-4.267 6.32-7.798 11.03-10.299 4.71-2.501 10-3.678 15.89-3.678 2.5 0 4.85.147 7.21.588 2.35.442 3.68.589 4.41.736V79.228c-1.03 0-2.65-.148-4.71-.295h-5.15l.15-.147ZM1596.1 382.896h-87.24v-72.827h-19.87v163.752h19.87v-73.269h87.24v73.269h19.86V310.069h-19.86v72.827ZM1738.67 362.887c-5.15-4.708-10.74-8.239-17.07-10.299-6.33-2.059-12.51-3.236-18.98-3.236-11.03 0-20.74 2.648-28.98 8.092-8.24 5.443-14.72 12.947-19.42 22.51-4.71 9.563-6.92 20.745-6.92 33.25 0 12.506 2.36 23.541 6.92 33.104 4.56 9.563 11.18 16.772 19.71 22.069 8.53 5.296 18.69 7.798 30.6 7.798 8.24 0 15.75-1.325 22.51-3.826 6.62-2.648 12.22-6.179 16.78-10.887 4.56-4.708 7.79-10.152 9.71-16.331l-18.25-5.15c-1.62 4.267-3.82 7.798-6.76 10.741-2.95 2.942-6.48 5.002-10.45 6.326-3.97 1.471-8.53 2.06-13.54 2.06-7.65 0-14.27-1.618-20.01-5.002-5.73-3.384-10.29-8.239-13.53-14.566-2.94-5.738-4.27-12.947-4.56-21.039h89.01v-7.945c0-11.476-1.47-21.186-4.56-28.984-3.09-7.797-7.06-14.124-12.21-18.979v.294Zm-72.09 39.577c.29-5.738 1.61-11.034 4.11-16.184 2.95-5.885 7.07-10.74 12.66-14.418 5.44-3.678 11.91-5.591 19.42-5.591 6.77 0 12.8 1.619 17.8 4.708 5 3.09 8.98 7.504 11.62 12.947 2.8 5.444 4.12 11.623 4.12 18.538h-69.73ZM1859.75 356.561c-4.85-2.943-9.86-4.855-15.01-5.738s-9.71-1.471-13.68-1.471c-6.18 0-12.5.882-18.83 2.501-6.33 1.618-12.21 4.561-17.51 8.827-5.3 4.12-9.71 10.005-12.8 17.508l17.95 6.327c2.06-4.414 5.74-8.681 10.74-12.653 5.15-3.972 12.21-5.885 21.19-5.885 8.97 0 15.15 2.207 19.42 6.621 4.26 4.413 6.47 10.446 6.47 18.39v.589c0 3.09-1.03 5.149-3.24 6.326-2.2 1.177-5.59 2.06-10.29 2.649-4.71.441-10.75 1.177-18.25 2.207-5.74.735-11.33 1.765-17.07 2.942-5.59 1.324-10.74 3.09-15.44 5.591-4.71 2.501-8.39 5.885-11.19 10.299-2.79 4.413-4.11 10.151-4.11 17.213 0 7.945 1.91 14.86 5.59 20.451 3.67 5.591 8.82 9.858 15.15 12.8 6.33 2.943 13.39 4.414 21.19 4.414 7.21 0 13.24-1.03 18.09-3.237 5.01-2.06 8.98-4.708 11.92-7.798 2.94-3.089 5.15-5.885 6.33-8.533h1.03v16.625h18.83v-80.919c0-9.711-1.62-17.508-4.86-23.393-3.23-5.885-7.21-10.152-12.06-13.095l.44.442Zm-2.06 72.827c0 5.15-1.32 10.005-3.97 14.566-2.65 4.708-6.48 8.386-11.62 11.329-5.15 2.942-11.48 4.413-18.98 4.413-7.51 0-13.69-1.618-18.54-5.002-4.86-3.384-7.36-8.239-7.36-14.86 0-4.855 1.33-8.533 3.83-11.328 2.65-2.796 6.03-4.856 10.3-6.327 4.26-1.471 8.82-2.501 13.68-3.089 2.06-.295 4.71-.589 7.94-1.03 3.24-.442 6.62-.883 10.16-1.472 3.53-.588 6.62-1.177 9.26-2.059 2.65-.736 4.42-1.619 5.3-2.649v17.508ZM1929.93 310.069h-18.83v163.752h18.83V310.069ZM2013.2 456.754c-1.32.294-3.09.294-5.15.294-2.79 0-5.44-.441-7.79-1.324-2.51-.883-4.56-2.648-6.04-5.296-1.61-2.649-2.35-6.621-2.35-11.918v-71.65h26.19v-16.037h-26.19v-29.425h-18.83v29.425h-18.54v16.037h18.54v76.8c0 7.209 1.62 13.094 5 17.802s7.5 8.239 12.65 10.446c5.15 2.207 10.3 3.384 15.6 3.384 3.53 0 6.47-.294 8.68-.736 2.21-.441 4.12-1.03 5.3-1.471l-3.83-16.92c-.74.148-1.91.295-3.24.589ZM2127.67 354.354c-6.33-3.384-13.68-5.002-21.92-5.002-9.71 0-17.36 1.912-23.1 5.591-5.74 3.825-10.15 8.827-12.95 15.154h-1.62v-60.175h-18.83v163.752h18.83v-73.858c0-7.209 1.48-13.241 4.27-18.244 2.8-5.002 6.62-8.827 11.48-11.475 4.85-2.649 10.44-3.973 16.62-3.973 8.83 0 15.89 2.648 20.89 8.092 5.01 5.444 7.51 12.947 7.51 22.658v76.8h18.83v-77.977c0-10.594-1.77-19.274-5.3-26.042-3.53-6.768-8.38-11.917-14.71-15.301ZM2320.99 356.561c-4.85-2.943-9.85-4.855-15-5.738s-9.71-1.471-13.69-1.471c-6.18 0-12.5.882-18.83 2.501-6.32 1.618-12.21 4.561-17.51 8.827-5.29 4.12-9.71 10.005-12.8 17.508l17.95 6.327c2.06-4.414 5.74-8.681 10.74-12.653 5.15-3.972 12.21-5.885 21.19-5.885 8.97 0 15.15 2.207 19.42 6.621 4.27 4.413 6.47 10.446 6.47 18.39v.589c0 3.09-1.03 5.149-3.23 6.326-2.21 1.177-5.59 2.06-10.3 2.649-4.71.441-10.74 1.177-18.25 2.207-5.73.735-11.32 1.765-17.06 2.942-5.59 1.324-10.74 3.09-15.45 5.591-4.71 2.501-8.39 5.885-11.18 10.299-2.8 4.413-4.12 10.151-4.12 17.213 0 7.945 1.91 14.86 5.59 20.451 3.68 5.591 8.83 9.858 15.15 12.8 6.33 2.943 13.39 4.414 21.19 4.414 7.21 0 13.24-1.03 18.1-3.237 5-2.06 8.97-4.708 11.91-7.798 2.95-3.089 5.15-5.885 6.33-8.533h1.03v16.625h18.83v-80.919c0-9.711-1.62-17.508-4.85-23.393-3.24-5.885-7.21-10.152-12.07-13.095l.44.442Zm-2.06 72.827c0 5.15-1.32 10.005-3.97 14.566-2.65 4.708-6.47 8.386-11.62 11.329-5.15 2.942-11.48 4.413-18.98 4.413s-13.68-1.618-18.54-5.002c-4.85-3.384-7.36-8.239-7.36-14.86 0-4.855 1.33-8.533 3.83-11.328 2.65-2.796 6.03-4.856 10.3-6.327 4.27-1.471 8.83-2.501 13.68-3.089 2.06-.295 4.71-.589 7.95-1.03 3.23-.442 6.62-.883 10.15-1.472 3.53-.588 6.62-1.177 9.27-2.059 2.65-.736 4.41-1.619 5.29-2.649v17.508ZM2449.88 354.501c-6.18-3.384-13.54-5.002-21.78-5.002-9.27 0-16.77 1.912-22.66 5.738-5.88 3.825-10.29 8.827-13.09 15.154h-1.62v-19.274h-18.24v122.851h18.83V400.11c0-7.209 1.32-13.241 4.12-18.243 2.65-5.003 6.47-8.828 11.18-11.476 4.71-2.648 10.01-3.973 16.04-3.973 8.68 0 15.59 2.649 20.6 8.092 5 5.444 7.5 12.948 7.5 22.658v76.8h18.83v-77.977c0-10.446-1.76-19.127-5.15-25.894-3.53-6.915-8.24-11.918-14.56-15.302v-.294ZM2588.03 370.538h-1.62c-1.32-2.06-3.38-4.855-5.74-8.239-2.5-3.384-6.03-6.327-10.74-8.975-4.7-2.648-11.03-3.972-18.98-3.972-10.29 0-19.42 2.648-27.36 7.797-7.95 5.15-13.98 12.506-18.54 21.922-4.56 9.416-6.62 20.745-6.62 33.545s2.21 24.276 6.62 33.839c4.41 9.563 10.59 16.92 18.39 22.069 7.8 5.149 16.92 7.798 27.07 7.798 7.95 0 14.27-1.324 18.98-3.973 4.71-2.648 8.39-5.59 10.89-8.974 2.5-3.384 4.56-6.18 5.88-8.387h2.21v18.833h18.24V310.069h-18.83v60.469h.15Zm-3.83 66.354c-2.64 7.062-6.62 12.506-11.91 16.478-5.3 3.972-11.63 5.885-19.28 5.885s-14.41-2.06-19.71-6.326c-5.3-4.12-9.27-9.858-11.92-16.92-2.65-7.062-3.97-15.007-3.97-23.834 0-8.828 1.32-16.479 3.97-23.393 2.65-6.915 6.62-12.506 11.92-16.479 5.3-4.119 11.92-6.179 20.01-6.179 8.09 0 14.12 1.913 19.42 5.738 5.3 3.825 9.12 9.269 11.77 16.184 2.65 6.915 3.97 15.007 3.97 24.129 0 9.121-1.32 17.508-4.12 24.57l-.15.147ZM2748.84 333.904c7.94-5.003 17.06-7.504 26.92-7.504 5.45 0 10.6.736 15.6 2.207 5 1.471 9.56 3.678 13.68 6.621 4.12 2.942 7.65 6.62 10.59 10.887 2.95 4.267 5.01 9.269 6.18 15.007h19.86c-1.47-8.386-4.26-15.89-8.09-22.51-3.97-6.621-8.82-12.212-14.71-16.773-5.88-4.561-12.51-8.092-19.71-10.593-7.21-2.354-15.01-3.531-23.25-3.531-13.98 0-26.34 3.384-37.22 10.299-10.89 6.768-19.42 16.478-25.6 29.131-6.18 12.653-9.42 27.513-9.42 44.726 0 17.214 3.09 32.221 9.42 44.727 6.32 12.506 14.86 22.216 25.6 29.131 10.88 6.768 23.24 10.299 37.22 10.299 8.24 0 16.04-1.177 23.25-3.531a65.066 65.066 0 0 0 19.71-10.446c5.89-4.561 10.74-10.152 14.71-16.773 3.98-6.62 6.62-14.124 8.09-22.51h-19.86c-1.17 5.591-3.23 10.593-6.18 15.007-2.94 4.414-6.47 7.945-10.59 10.887-4.12 2.943-8.68 5.15-13.68 6.621s-10.3 2.207-15.6 2.207c-9.86 0-18.83-2.501-26.92-7.504-8.09-5.002-14.42-12.358-19.13-22.216-4.71-9.857-7.06-21.774-7.06-35.899 0-14.124 2.35-26.188 7.06-35.898 4.71-9.711 11.04-17.067 19.13-22.217v.148ZM2946.58 356.561c-4.86-2.943-9.86-4.855-15.01-5.738s-9.71-1.471-13.68-1.471c-6.18 0-12.51.882-18.84 2.501-6.32 1.618-12.21 4.561-17.5 8.827-5.3 4.12-9.71 10.005-12.8 17.508l17.94 6.327c2.06-4.414 5.74-8.681 10.74-12.653 5.15-3.972 12.22-5.885 21.19-5.885 8.98 0 15.16 2.207 19.42 6.621 4.27 4.413 6.48 10.446 6.48 18.39v.589c0 3.09-1.03 5.149-3.24 6.326-2.21 1.177-5.59 2.06-10.3 2.649-4.71.441-10.74 1.177-18.24 2.207-5.74.735-11.33 1.765-17.07 2.942-5.59 1.324-10.74 3.09-15.45 5.591-4.71 2.501-8.39 5.885-11.18 10.299-2.8 4.413-4.12 10.151-4.12 17.213 0 7.945 1.91 14.86 5.59 20.451 3.68 5.591 8.83 9.858 15.16 12.8 6.32 2.943 13.38 4.414 21.18 4.414 7.21 0 13.24-1.03 18.1-3.237 5-2.06 8.97-4.708 11.91-7.798 2.95-3.089 5.15-5.885 6.33-8.533h1.03v16.625h18.83v-80.919c0-9.711-1.61-17.508-4.85-23.393-3.24-5.885-7.21-10.152-12.07-13.095l.45.442Zm-2.06 72.827c0 5.15-1.33 10.005-3.98 14.566-2.65 4.708-6.47 8.386-11.62 11.329-5.15 2.942-11.48 4.413-18.98 4.413s-13.68-1.618-18.54-5.002c-4.85-3.384-7.35-8.239-7.35-14.86 0-4.855 1.32-8.533 3.82-11.328 2.65-2.796 6.03-4.856 10.3-6.327 4.27-1.471 8.83-2.501 13.68-3.089 2.06-.295 4.71-.589 7.95-1.03 3.23-.442 6.62-.883 10.15-1.472 3.53-.588 6.62-1.177 9.27-2.059 2.65-.736 4.41-1.619 5.3-2.649v17.508ZM3049.56 349.057c-7.35 0-13.97 1.913-19.86 5.738-5.88 3.826-9.86 8.681-12.21 14.86h-1.32v-18.538h-18.25v122.851h18.84v-77.683c0-5.591 1.32-10.446 3.97-14.86 2.65-4.266 6.32-7.797 11.03-10.299 4.71-2.501 10.01-3.678 15.89-3.678 2.5 0 4.86.147 7.21.589 2.36.441 3.68.588 4.41.735v-19.126c-1.03 0-2.64-.147-4.7-.294h-5.15l.14-.295ZM3163.59 362.887c-5.15-4.708-10.74-8.239-17.07-10.299-6.32-2.059-12.5-3.236-18.98-3.236-11.03 0-20.74 2.648-28.98 8.092-8.24 5.443-14.71 12.947-19.42 22.51-4.71 9.563-6.92 20.745-6.92 33.25 0 12.506 2.36 23.541 6.92 33.104 4.56 9.563 11.18 16.772 19.71 22.069 8.54 5.296 18.69 7.798 30.6 7.798 8.24 0 15.75-1.325 22.52-3.826 6.62-2.648 12.21-6.179 16.77-10.887 4.56-4.708 7.8-10.152 9.71-16.331l-18.25-5.15c-1.61 4.267-3.82 7.798-6.76 10.741-2.95 2.942-6.48 5.002-10.45 6.326-3.97 1.471-8.53 2.06-13.54 2.06-7.65 0-14.27-1.618-20-5.002-5.74-3.384-10.3-8.239-13.54-14.566-2.94-5.738-4.27-12.947-4.56-21.039h89.01v-7.945c0-11.476-1.47-21.186-4.56-28.984-3.09-7.797-7.06-14.124-12.21-18.979v.294Zm-72.09 39.577c.29-5.738 1.61-11.034 4.12-16.184 2.94-5.885 7.06-10.74 12.65-14.418 5.44-3.678 11.92-5.591 19.42-5.591 6.77 0 12.8 1.619 17.8 4.708 5 3.09 8.98 7.504 11.62 12.947 2.8 5.444 4.12 11.623 4.12 18.538h-69.73ZM3294.82 400.552h73.86v-17.656h-73.86v-55.319h79.01v-17.508h-98.87v163.752h100.19v-17.656h-80.33v-55.613ZM3480.06 350.97l-29.43 50.17-29.42-50.17h-21.78l38.99 61.352-38.99 61.499h21.78l29.42-47.669 29.43 47.669h21.77l-39.72-61.499 39.72-61.352h-21.77ZM3554.06 372.009c5.45-3.825 11.92-5.738 19.28-5.738 8.38 0 15 2.207 19.86 6.474 5 4.414 8.09 9.269 9.56 14.86h18.83c-1.03-7.651-3.82-14.419-8.24-20.157-4.41-5.738-10.15-10.299-17.06-13.388-6.92-3.237-14.72-4.855-23.4-4.855-11.03 0-20.74 2.648-28.98 8.092-8.24 5.443-14.71 12.947-19.42 22.51-4.56 9.563-6.92 20.598-6.92 33.103 0 12.506 2.21 23.099 6.77 32.662 4.42 9.564 10.89 17.067 19.13 22.511 8.24 5.443 18.24 8.092 29.72 8.092 9.12 0 17.06-1.766 23.83-5.15 6.92-3.384 12.36-7.945 16.48-13.683 4.12-5.737 6.77-12.358 7.95-19.567h-18.84c-1.17 4.413-3.09 8.239-5.88 11.476-2.8 3.236-6.18 5.59-10.15 7.356-3.98 1.765-8.39 2.501-13.39 2.501-7.51 0-13.98-1.913-19.42-5.885-5.59-3.825-9.71-9.416-12.8-16.331-2.94-7.062-4.56-15.301-4.56-24.864 0-9.564 1.47-17.361 4.56-24.276 3.09-6.915 7.35-12.212 12.94-16.037l.15.294ZM3734.88 362.887c-5.15-4.708-10.74-8.239-17.07-10.299-6.33-2.059-12.5-3.236-18.98-3.236-11.03 0-20.74 2.648-28.98 8.092-8.24 5.443-14.71 12.947-19.42 22.51-4.71 9.563-6.92 20.745-6.92 33.25 0 12.506 2.36 23.541 6.92 33.104 4.56 9.563 11.18 16.772 19.71 22.069 8.54 5.296 18.69 7.798 30.6 7.798 8.24 0 15.75-1.325 22.51-3.826 6.63-2.648 12.22-6.179 16.78-10.887 4.56-4.708 7.79-10.152 9.71-16.331l-18.25-5.15c-1.61 4.267-3.82 7.798-6.76 10.741-2.95 2.942-6.48 5.002-10.45 6.326-3.97 1.471-8.53 2.06-13.54 2.06-7.65 0-14.27-1.618-20-5.002-5.74-3.384-10.3-8.239-13.54-14.566-2.94-5.738-4.27-12.947-4.56-21.039h89.01v-7.945c0-11.476-1.47-21.186-4.56-28.984-3.09-7.797-7.06-14.124-12.21-18.979v.294Zm-72.09 39.577c.29-5.738 1.61-11.034 4.12-16.184 2.94-5.885 7.06-10.74 12.65-14.418 5.44-3.678 11.92-5.591 19.42-5.591 6.77 0 12.8 1.619 17.8 4.708 5 3.09 8.98 7.504 11.62 12.947 2.8 5.444 4.12 11.623 4.12 18.538h-69.73ZM3799.17 310.069h-18.83v163.752h18.83V310.069ZM3852.58 310.069h-18.83v163.752h18.83V310.069ZM3972.78 362.887c-5.15-4.708-10.74-8.239-17.06-10.299-6.33-2.059-12.51-3.236-18.98-3.236-11.04 0-20.75 2.648-28.99 8.092-8.24 5.443-14.71 12.947-19.42 22.51-4.71 9.563-6.91 20.745-6.91 33.25 0 12.506 2.35 23.541 6.91 33.104 4.56 9.563 11.18 16.772 19.72 22.069 8.53 5.296 18.68 7.798 30.6 7.798 8.24 0 15.74-1.325 22.51-3.826 6.62-2.648 12.21-6.179 16.77-10.887 4.56-4.708 7.8-10.152 9.71-16.331l-18.24-5.15c-1.62 4.267-3.83 7.798-6.77 10.741-2.94 2.942-6.47 5.002-10.44 6.326-3.98 1.471-8.54 2.06-13.54 2.06-7.65 0-14.27-1.618-20.01-5.002-5.74-3.384-10.3-8.239-13.54-14.566-2.94-5.738-4.26-12.947-4.56-21.039h89.02v-7.945c0-11.476-1.48-21.186-4.57-28.984-3.09-7.797-7.06-14.124-12.21-18.979v.294Zm-72.09 39.577c.3-5.738 1.62-11.034 4.12-16.184 2.94-5.885 7.06-10.74 12.65-14.418 5.45-3.678 11.92-5.591 19.42-5.591 6.77 0 12.8 1.619 17.81 4.708 5 3.09 8.97 7.504 11.62 12.947 2.79 5.444 4.12 11.623 4.12 18.538h-69.74ZM4095.78 354.501c-6.18-3.384-13.54-5.002-21.78-5.002-9.27 0-16.77 1.912-22.65 5.738-5.89 3.825-10.3 8.827-13.1 15.154h-1.62v-19.274h-18.24v122.851h18.83V400.11c0-7.209 1.33-13.241 4.12-18.243 2.65-5.003 6.47-8.828 11.18-11.476 4.71-2.648 10.01-3.973 16.04-3.973 8.68 0 15.6 2.649 20.6 8.092 5 5.444 7.5 12.948 7.5 22.658v76.8h18.83v-77.977c0-10.446-1.76-19.127-5.15-25.894-3.53-6.915-8.24-11.918-14.56-15.302v-.294ZM4180.67 372.009c5.45-3.825 11.92-5.738 19.27-5.738 8.39 0 15.01 2.207 19.87 6.474 5 4.414 8.09 9.269 9.56 14.86h18.83c-1.03-7.651-3.82-14.419-8.24-20.157-4.41-5.738-10.15-10.299-17.06-13.388-6.92-3.237-14.72-4.855-23.4-4.855-11.03 0-20.74 2.648-28.98 8.092-8.24 5.443-14.71 12.947-19.42 22.51-4.56 9.563-6.92 20.598-6.92 33.103 0 12.506 2.21 23.099 6.77 32.662 4.41 9.564 10.89 17.067 19.13 22.511 8.24 5.443 18.24 8.092 29.72 8.092 9.12 0 17.06-1.766 23.83-5.15 6.92-3.384 12.36-7.945 16.48-13.683 4.12-5.737 6.77-12.358 7.95-19.567h-18.84c-1.17 4.413-3.09 8.239-5.88 11.476-2.8 3.236-6.18 5.59-10.15 7.356-3.98 1.765-8.39 2.501-13.39 2.501-7.51 0-13.98-1.913-19.42-5.885-5.59-3.825-9.71-9.416-12.8-16.331-2.95-7.062-4.56-15.301-4.56-24.864 0-9.564 1.47-17.361 4.56-24.276 3.09-6.915 7.35-12.212 12.94-16.037l.15.294ZM4378.12 410.85c0-11.475-1.48-21.186-4.57-28.983-3.08-7.798-7.06-14.125-12.21-18.98-5.15-4.708-10.74-8.239-17.06-10.299-6.33-2.059-12.51-3.236-18.98-3.236-11.04 0-20.75 2.648-28.99 8.092-8.24 5.443-14.71 12.947-19.42 22.51-4.71 9.563-6.91 20.745-6.91 33.25 0 12.506 2.35 23.541 6.91 33.104 4.56 9.563 11.18 16.772 19.72 22.069 8.53 5.296 18.68 7.798 30.6 7.798 8.24 0 15.74-1.325 22.51-3.826 6.62-2.648 12.21-6.179 16.77-10.887 4.56-4.708 7.8-10.152 9.71-16.331l-18.24-5.15c-1.62 4.267-3.83 7.798-6.77 10.741-2.94 2.942-6.47 5.002-10.44 6.326-3.98 1.471-8.54 2.06-13.54 2.06-7.65 0-14.27-1.618-20.01-5.002-5.74-3.384-10.3-8.239-13.53-14.566-2.95-5.738-4.27-12.947-4.57-21.039h89.02v-7.945.294Zm-88.87-8.386c.3-5.738 1.62-11.034 4.12-16.184 2.94-5.885 7.06-10.74 12.65-14.418 5.45-3.678 11.92-5.591 19.42-5.591 6.77 0 12.8 1.619 17.81 4.708 5 3.09 8.97 7.504 11.62 12.947 2.8 5.444 4.12 11.623 4.12 18.538h-69.74Z" fill="currentColor"></path></svg></a><div class="Header_wrapper__8WbBA"><div class="Header_search__NacHH"><form id="global-nav-search-form" role="search" action="/search" class="Search_search__do5Gn"><label class="Search_label___vtvh" for="autocomplete">Search NICE…</label><div class="Autocomplete_ac__CP9eu"><div class="autocomplete__wrapper"><input type="search" id="autocomplete" name="q" class="autocomplete__input autocomplete__input--default" placeholder="Search NICE…" data-hj-allow="" maxLength="512" value=""/></div></div><button class="Search_button__54cGs" type="submit" aria-label="Perform search"><svg width="1em" height="1em" viewBox="0 0 512 512" fill="none" xmlns="http://www.w3.org/2000/svg" class="Search_icon___aEsS" aria-hidden="true" focusable="false"><path d="M83.784 476.472 197.112 363.16c30.144 20.32 65.056 30.528 100.032 30.528 45.904 0 91.776-17.488 126.8-52.528 70.064-70.064 70.064-183.584 0-253.616C388.936 52.504 343.048 35 297.144 35c-45.904 0-91.808 17.504-126.848 52.528-61.696 61.696-68.976 157.12-21.968 226.864L35 427.752l48.784 48.72Zm213.36-137.952c-33.168 0-64.352-12.896-87.792-36.368-48.416-48.448-48.416-127.2 0-175.616 23.44-23.44 54.64-36.352 87.792-36.352s64.336 12.912 87.776 36.368c23.44 23.456 36.384 54.64 36.384 87.792s-12.928 64.352-36.384 87.792c-23.456 23.472-54.624 36.368-87.776 36.368v.016Z" fill="currentColor"></path></svg></button><a href="#content-start" class="SkipLink_link__RWkQR">Skip to content</a></form></div><button class="Header_mobileMenuBtn__pbI_i" id="header-menu-button" type="button" aria-controls="header-menu" aria-expanded="false" aria-haspopup="menu" aria-label="Expand site menu">Menu</button><div class="Header_account___MDc2"><a data-tracking="Sign in" href="https://accounts.nice.org.uk/signin" class="Account_button__YKHtB">Sign in</a></div></div></div><div id="header-menu" class="Nav_wrapper__E2OlM"><nav class="Nav_nav__PR6Nm" aria-label="primary navigation" data-tracking="Primary navigation"><div class="Nav_menuWrapper__mGyWw"><ul class="NavLinks_menuList__Z3HaN" aria-labelledby="header-menu-button"><li data-tracking="Guidance"><a href="https://www.nice.org.uk/guidance" aria-current="true" class="NavLinks_link___hLDV" id="navlink-guidance"><span>Guidance</span></a></li><li data-tracking="Standards and indicators"><a href="https://www.nice.org.uk/standards-and-indicators" class="NavLinks_link___hLDV" id="navlink-standards-and-indicators"><span>Standards and indicators</span></a></li><li data-tracking="Life sciences"><a href="https://www.nice.org.uk/about/what-we-do/life-sciences" class="NavLinks_link___hLDV" id="navlink-life-sciences"><span>Life sciences</span></a></li><li data-tracking="British National Formulary (BNF)"><a href="https://bnf.nice.org.uk/" class="NavLinks_link___hLDV" id="navlink-bnf" aria-label="false"><span>British National Formulary (BNF)</span></a></li><li data-tracking="British National Formulary for Children (BNFC)"><a href="https://bnfc.nice.org.uk/" class="NavLinks_link___hLDV" id="navlink-bnfc" aria-label="false"><span>British National Formulary for Children (BNFC)</span></a></li><li data-tracking="Clinical Knowledge Summaries (CKS)"><a href="https://cks.nice.org.uk/" class="NavLinks_link___hLDV" id="navlink-cks" aria-label="false"><span>Clinical Knowledge Summaries (CKS)</span></a></li><li data-tracking="About"><a href="https://www.nice.org.uk/about" class="NavLinks_link___hLDV" id="navlink-about"><span>About</span></a></li></ul></div></nav></div></header></div></div><main class="Main_main__quUAo Main_withPadding__DVea8"><div class="container" data-component="container"><nav aria-label="Breadcrumbs" role="navigation" data-component="breadcrumbs"><ol class="breadcrumbs"><li class="breadcrumbs__crumb"><a href="/">Home</a></li><li class="breadcrumbs__crumb"><a href="/guidance">NICE guidance</a></li><li class="breadcrumbs__crumb"><span>Published</span></li></ol></nav><script type="application/ld+json">{"@context":"http://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"/","name":"Home"}},{"@type":"ListItem","position":2,"item":{"@id":"/guidance","name":"NICE guidance"}},{"@type":"ListItem","position":3,"item":{"name":"Published"}}]}</script><div class="page-header " data-component="page-header" id="content-start" data-testid="content-start"><h1 class="page-header__heading ">Published: Guidance, quality standards and advice</h1><p class="page-header__lead"><a href="#filters" class="SkipLink_skipLink__25piR">Skip to filters</a><a href="#results" class="SkipLink_skipLink__25piR">Skip to results</a></p></div><nav class="horizontal-nav" aria-label="Stages of guidance development"><ul class="horizontal-nav__list"><li class="horizontal-nav__item" data-component="horizontal-nav"><a class="horizontal-nav__link" aria-current="true" href="/guidance/published">Published</a></li><li class="horizontal-nav__item" data-component="horizontal-nav"><a class="horizontal-nav__link" aria-current="false" href="/guidance/inconsultation?ndt=Guidance&ngt=Technology%20appraisal%20guidance">In consultation</a></li><li class="horizontal-nav__item" data-component="horizontal-nav"><a class="horizontal-nav__link" aria-current="false" href="/guidance/indevelopment?ndt=Guidance&ngt=Technology%20appraisal%20guidance">In development</a></li><li class="horizontal-nav__item" data-component="horizontal-nav"><a class="horizontal-nav__link" aria-current="false" href="/guidance/awaiting-development?ndt=Guidance&ngt=Technology%20appraisal%20guidance">Awaiting development</a></li><li class="horizontal-nav__item" data-component="horizontal-nav"><a class="horizontal-nav__link" aria-current="false" href="/guidance/topic-selection?ndt=Guidance&ngt=Technology%20appraisal%20guidance">Topic selection</a></li></ul></nav><div class="grid grid--loose ProductListPage_sectionWrapper__M4hc9"><section data-g="12 md:4 lg:3" data-component="grid-item" class="ProductListPage_panelWrapper__EL_nO" aria-label="Filter results"><form id="filters" aria-label="Filter results"><div class="filter-panel" data-component="filter-panel"><h2 class="filter-panel__heading"><button aria-expanded="true" aria-controls="filter-panel-body" type="button"><svg width="1em" height="1em" viewBox="0 0 512 512" fill="none" xmlns="http://www.w3.org/2000/svg" class="filter-panel__heading-icon filter-panel__heading-icon--expanded" aria-hidden="true" focusable="false"><path d="M478.152 174c0 10.091-3.525 18.661-10.576 25.712l-186 186c-7.243 7.243-15.909 10.864-26 10.864-10.283 0-18.853-3.621-25.712-10.864l-186-186C36.621 192.853 33 184.283 33 174c0-10.091 3.621-18.757 10.864-26L65 126.576C72.424 119.525 81.09 116 91 116c10.091 0 18.661 3.525 25.712 10.576L255.576 265.44 394.44 126.576c7.051-7.051 15.621-10.576 25.712-10.576 9.909 0 18.576 3.525 26 10.576L467.576 148c7.051 7.424 10.576 16.091 10.576 26Z" fill="currentColor"></path></svg>Filter (2 applied)</button></h2><div id="filter-panel-body" class="filter-panel__body" aria-hidden="false"><a href="#results" class="SkipLink_skipLink__25piR">Skip to results</a><input type="hidden" name="ps" value=""/><input type="hidden" name="s"/><div class="filter-group"><h3 class="filter-group__heading"><span id="group-heading-keyword-or-reference-number">Keyword or reference number<!-- --> </span></h3><fieldset id="group-keyword-or-reference-number" aria-hidden="false" class="filter-group__options"><legend>Keyword or reference number</legend><div class="ph--c pt--c"><div class="input InlineTextFilter_input__bPVn_" data-component="input"><input name="q" class="input__input" id="q" type="text" placeholder="E.g. 'diabetes' or 'NG28'" autoComplete="off" spellcheck="false" value=""/></div><button type="submit" class="btn btn--secondary ml--0" data-component="button--secondary">Apply filter</button></div></fieldset></div><div class="filter-group"><h3 class="filter-group__heading"><span id="group-heading-last-updated-date">Last updated date<!-- --> </span></h3><fieldset id="group-last-updated-date" aria-hidden="false" class="filter-group__options"><legend>Last updated date</legend><div class="ph--c pt--c"><div class="input" data-component="input"><label class="input__label" for="from">From date</label><input name="from" class="input__input" id="from" type="date" pattern="[0-9]{4}-(0[1-9]|1[012])-(0[1-9]|1[0-9]|2[0-9]|3[01])" placeholder="yyyy-mm-dd" min="2000-01-01" max="2024-11-24" value=""/></div><div class="input" data-component="input"><label class="input__label" for="to">To date</label><input name="to" class="input__input" id="to" type="date" pattern="[0-9]{4}-(0[1-9]|1[012])-(0[1-9]|1[0-9]|2[0-9]|3[01])" placeholder="yyyy-mm-dd" min="2000-01-01" max="2024-11-24" value=""/></div><button type="submit" class="btn btn--secondary ml--0" data-component="button--secondary">Apply date filters</button></div></fieldset></div><div class="filter-group"><h3 class="filter-group__heading"><span id="group-heading-nai">Area of interest<!-- --> </span></h3><fieldset id="group-nai" aria-hidden="false" class="filter-group__options"><legend>Area of interest</legend><label for="filter_nai_covid-19" class="filter-option" data-component="filter-option"><input id="filter_nai_covid-19" type="checkbox" name="nai" title="Area of interest - COVID-19 (3)" value="COVID-19"/><span class="filter-option__text">COVID-19 (3)</span></label></fieldset></div><div class="filter-group"><h3 class="filter-group__heading"><span id="group-heading-ndt">Type<!-- --> </span><span class="filter-group__count"><span class="visually-hidden">(</span>1<!-- --> selected<span class="visually-hidden">)</span></span></h3><fieldset id="group-ndt" aria-hidden="false" class="filter-group__options"><legend>Type</legend><label for="filter_ndt_guidance" class="filter-option" data-component="filter-option"><input id="filter_ndt_guidance" type="checkbox" name="ndt" title="Type - Guidance (797)" checked="" value="Guidance"/><span class="filter-option__text">Guidance (797)</span></label></fieldset></div><div class="filter-group"><h3 class="filter-group__heading"><span id="group-heading-ngt">Guidance programme<!-- --> </span><span class="filter-group__count"><span class="visually-hidden">(</span>1<!-- --> selected<span class="visually-hidden">)</span></span></h3><fieldset id="group-ngt" aria-hidden="false" class="filter-group__options"><legend>Guidance programme</legend><label for="filter_ngt_antimicrobial-prescribing-guidelines" class="filter-option" data-component="filter-option"><input id="filter_ngt_antimicrobial-prescribing-guidelines" type="checkbox" name="ngt" title="Guidance programme - Antimicrobial prescribing guidelines (20)" value="Antimicrobial prescribing guidelines"/><span class="filter-option__text">Antimicrobial prescribing guidelines (20)</span></label><label for="filter_ngt_cancer-service-guidelines" class="filter-option" data-component="filter-option"><input id="filter_ngt_cancer-service-guidelines" type="checkbox" name="ngt" title="Guidance programme - Cancer service guidelines (8)" value="Cancer service guidelines"/><span class="filter-option__text">Cancer service guidelines (8)</span></label><label for="filter_ngt_clinical-guidelines" class="filter-option" data-component="filter-option"><input id="filter_ngt_clinical-guidelines" type="checkbox" name="ngt" title="Guidance programme - Clinical guidelines (225)" value="Clinical guidelines"/><span class="filter-option__text">Clinical guidelines (225)</span></label><label for="filter_ngt_covid-19-rapid-guidelines" class="filter-option" data-component="filter-option"><input id="filter_ngt_covid-19-rapid-guidelines" type="checkbox" name="ngt" title="Guidance programme - COVID-19 rapid guidelines (3)" value="COVID-19 rapid guidelines"/><span class="filter-option__text">COVID-19 rapid guidelines (3)</span></label><label for="filter_ngt_diagnostics-guidance" class="filter-option" data-component="filter-option"><input id="filter_ngt_diagnostics-guidance" type="checkbox" name="ngt" title="Guidance programme - Diagnostics guidance (50)" value="Diagnostics guidance"/><span class="filter-option__text">Diagnostics guidance (50)</span></label><label for="filter_ngt_health-technology-evaluations" class="filter-option" data-component="filter-option"><input id="filter_ngt_health-technology-evaluations" type="checkbox" name="ngt" title="Guidance programme - Health technology evaluations (18)" value="Health technology evaluations"/><span class="filter-option__text">Health technology evaluations (18)</span></label><label for="filter_ngt_highly-specialised-technologies-guidance" class="filter-option" data-component="filter-option"><input id="filter_ngt_highly-specialised-technologies-guidance" type="checkbox" name="ngt" title="Guidance programme - Highly specialised technologies guidance (28)" value="Highly specialised technologies guidance"/><span class="filter-option__text">Highly specialised technologies guidance (28)</span></label><label for="filter_ngt_interventional-procedures-guidance" class="filter-option" data-component="filter-option"><input id="filter_ngt_interventional-procedures-guidance" type="checkbox" name="ngt" title="Guidance programme - Interventional procedures guidance (603)" value="Interventional procedures guidance"/><span class="filter-option__text">Interventional procedures guidance (603)</span></label><label for="filter_ngt_medical-technologies-guidance" class="filter-option" data-component="filter-option"><input id="filter_ngt_medical-technologies-guidance" type="checkbox" name="ngt" title="Guidance programme - Medical technologies guidance (67)" value="Medical technologies guidance"/><span class="filter-option__text">Medical technologies guidance (67)</span></label><label for="filter_ngt_medicines-practice-guidelines" class="filter-option" data-component="filter-option"><input id="filter_ngt_medicines-practice-guidelines" type="checkbox" name="ngt" title="Guidance programme - Medicines practice guidelines (5)" value="Medicines practice guidelines"/><span class="filter-option__text">Medicines practice guidelines (5)</span></label><label for="filter_ngt_nice-guidelines" class="filter-option" data-component="filter-option"><input id="filter_ngt_nice-guidelines" type="checkbox" name="ngt" title="Guidance programme - NICE guidelines (341)" value="NICE guidelines"/><span class="filter-option__text">NICE guidelines (341)</span></label><label for="filter_ngt_public-health-guidelines" class="filter-option" data-component="filter-option"><input id="filter_ngt_public-health-guidelines" type="checkbox" name="ngt" title="Guidance programme - Public health guidelines (61)" value="Public health guidelines"/><span class="filter-option__text">Public health guidelines (61)</span></label><label for="filter_ngt_safe-staffing-guidelines" class="filter-option" data-component="filter-option"><input id="filter_ngt_safe-staffing-guidelines" type="checkbox" name="ngt" title="Guidance programme - Safe staffing guidelines (2)" value="Safe staffing guidelines"/><span class="filter-option__text">Safe staffing guidelines (2)</span></label><label for="filter_ngt_social-care-guidelines" class="filter-option" data-component="filter-option"><input id="filter_ngt_social-care-guidelines" type="checkbox" name="ngt" title="Guidance programme - Social care guidelines (71)" value="Social care guidelines"/><span class="filter-option__text">Social care guidelines (71)</span></label><label for="filter_ngt_technology-appraisal-guidance" class="filter-option" data-component="filter-option"><input id="filter_ngt_technology-appraisal-guidance" type="checkbox" name="ngt" title="Guidance programme - Technology appraisal guidance (797)" checked="" value="Technology appraisal guidance"/><span class="filter-option__text">Technology appraisal guidance (797)</span></label></fieldset></div><button type="submit" class="btn filter-panel__submit">Apply filters</button></div></div></form></section><section data-g="12 md:8 lg:9" data-component="grid-item" aria-labelledby="filter-summary"><div class="filter-summary" data-component="filter-summary" id="filter-summary"><div class="filter-summary__count"><h2 class="h5 mv--0">Showing <!-- -->1<!-- --> to <!-- -->10<!-- --> of <!-- -->797</h2></div><div class="filter-summary__sorting"><label class="filter-summary__sort-label" for="sorting-options">Sort by</label><select id="sorting-options" class="filter-summary__select" name="s"><option value="Date" selected="">Date</option><option value="Title">Title</option></select><button type="submit">Apply sorting</button></div><ul class="filter-summary__filters hide-print" aria-label="Active filters"><li class="filter-summary__filter"><span class="tag tag--outline" data-component="tag">Type: Guidance<a class="tag__remove" href="/guidance/published?sp=on&ngt=Technology%20appraisal%20guidance"><span class="visually-hidden">Remove <!-- -->Type: Guidance<!-- --> filter</span></a></span></li><li class="filter-summary__filter"><span class="tag tag--outline" data-component="tag">Guidance programme: Technology appraisal guidance<a class="tag__remove" href="/guidance/published?sp=on&ndt=Guidance"><span class="visually-hidden">Remove <!-- -->Guidance programme: Technology appraisal guidance<!-- --> filter</span></a></span></li></ul></div><div class="ProductListPage_tableWrapper__oCkQq"><table class="table ProductListPage_table__6QiDc" data-component="table" aria-describedby="filter-summary" id="results"><caption class="visually-hidden">Published guidance, NICE advice and quality standards</caption><thead><tr><th scope="col">Title</th><th scope="col">Reference number</th><th scope="col">Published</th><th scope="col">Last updated</th></tr></thead><tbody><tr><td><a href="https://www.nice.org.uk/guidance/ta1017">Pembrolizumab with chemotherapy before surgery (neoadjuvant) then alone after surgery (adjuvant) for treating resectable non-small-cell lung cancer</a></td><td>TA1017</td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-11-20T12:00:00" data-shortdate="20/11/2024"><span>20 November 2024</span></time></td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-11-20T12:00:00" data-shortdate="20/11/2024"><span>20 November 2024</span></time></td></tr><tr><td><a href="https://www.nice.org.uk/guidance/ta1018">Fedratinib for treating disease-related splenomegaly or symptoms in myelofibrosis</a></td><td>TA1018</td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-11-20T12:00:00" data-shortdate="20/11/2024"><span>20 November 2024</span></time></td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-11-20T12:00:00" data-shortdate="20/11/2024"><span>20 November 2024</span></time></td></tr><tr><td><a href="https://www.nice.org.uk/guidance/ta1019">Crovalimab for treating paroxysmal nocturnal haemoglobinuria in people 12 years and over</a></td><td>TA1019</td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-11-20T12:00:00" data-shortdate="20/11/2024"><span>20 November 2024</span></time></td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-11-20T12:00:00" data-shortdate="20/11/2024"><span>20 November 2024</span></time></td></tr><tr><td><a href="https://www.nice.org.uk/guidance/ta1016">Elafibranor for previously treated primary biliary cholangitis</a></td><td>TA1016</td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-11-14T12:00:00" data-shortdate="14/11/2024"><span>14 November 2024</span></time></td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-11-14T12:00:00" data-shortdate="14/11/2024"><span>14 November 2024</span></time></td></tr><tr><td><a href="https://www.nice.org.uk/guidance/ta1014">Alectinib for adjuvant treatment of ALK-positive non-small-cell lung cancer</a></td><td>TA1014</td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-11-13T12:00:00" data-shortdate="13/11/2024"><span>13 November 2024</span></time></td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-11-13T12:00:00" data-shortdate="13/11/2024"><span>13 November 2024</span></time></td></tr><tr><td><a href="https://www.nice.org.uk/guidance/ta1015">Teclistamab for treating relapsed and refractory multiple myeloma after 3 or more treatments</a></td><td>TA1015</td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-11-13T12:00:00" data-shortdate="13/11/2024"><span>13 November 2024</span></time></td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-11-13T12:00:00" data-shortdate="13/11/2024"><span>13 November 2024</span></time></td></tr><tr><td><a href="https://www.nice.org.uk/guidance/ta1012">Avapritinib for treating advanced systemic mastocytosis</a></td><td>TA1012</td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-11-06T12:00:00" data-shortdate="6/11/2024"><span>6 November 2024</span></time></td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-11-06T12:00:00" data-shortdate="6/11/2024"><span>6 November 2024</span></time></td></tr><tr><td><a href="https://www.nice.org.uk/guidance/ta1010">Danicopan with ravulizumab or eculizumab for treating paroxysmal nocturnal haemoglobinuria</a></td><td>TA1010</td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-10-23T12:00:00" data-shortdate="23/10/2024"><span>23 October 2024</span></time></td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-10-23T12:00:00" data-shortdate="23/10/2024"><span>23 October 2024</span></time></td></tr><tr><td><a href="https://www.nice.org.uk/guidance/ta1013">Quizartinib for induction, consolidation and maintenance treatment of newly diagnosed FLT3-ITD-positive acute myeloid leukaemia</a></td><td>TA1013</td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-10-23T12:00:00" data-shortdate="23/10/2024"><span>23 October 2024</span></time></td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-10-23T12:00:00" data-shortdate="23/10/2024"><span>23 October 2024</span></time></td></tr><tr><td><a href="https://www.nice.org.uk/guidance/ta1011">Belzutifan for treating tumours associated with von Hippel-Lindau disease</a></td><td>TA1011</td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-10-16T12:00:00" data-shortdate="16/10/2024"><span>16 October 2024</span></time></td><td><time class="ResponsiveDate_date__R_aFK" dateTime="2024-10-16T12:00:00" data-shortdate="16/10/2024"><span>16 October 2024</span></time></td></tr></tbody></table></div><nav role="navigation" aria-label="Pagination" class="pagination " data-component="pagination"><ol class="pagination__list"><li class="pagination__item pagination__item--current" aria-current="true"><span class="pagination__inactive"><span class="visually-hidden">Current page </span>1</span></li><li class="pagination__item"><a class="pagination__link" aria-label="Go to page 2" href="/guidance/published?ndt=Guidance&ngt=Technology%20appraisal%20guidance&pa=2">2</a></li><li class="pagination__item"><a class="pagination__link" aria-label="Go to page 3" href="/guidance/published?ndt=Guidance&ngt=Technology%20appraisal%20guidance&pa=3">3</a></li><li class="pagination__item"><span class="pagination__inactive">…</span></li><li class="pagination__item"><a class="pagination__link" aria-label="Go to page 80" href="/guidance/published?ndt=Guidance&ngt=Technology%20appraisal%20guidance&pa=80">80</a></li><li class="pagination__item pagination__item--count"><span>Page <strong>1</strong> of <strong>80</strong></span></li><li class="pagination__item pagination__item--bookend"><a class="pagination__link" href="/guidance/published?ndt=Guidance&ngt=Technology%20appraisal%20guidance&pa=2">Next page</a></li></ol></nav><div class="grid grid--middle mt--d"><div data-g="12 sm:6" data-component="grid-item" class="mb--e mb--0-sm"></div><div data-g="12 sm:6" data-component="grid-item" class="text-right"><h3 class="ProductListPage_resultsPerPageHeading__epr_j">Results per page</h3><ol class="list list--piped ProductListPage_resultsPerPageList__lh0dL"><li>10</li><li><a aria-label="Show 25 results per page" href="/guidance/published?ndt=Guidance&ngt=Technology%20appraisal%20guidance&ps=25">25</a></li><li><a aria-label="Show 50 results per page" href="/guidance/published?ndt=Guidance&ngt=Technology%20appraisal%20guidance&ps=50">50</a></li><li><a aria-label="Show All results per page" href="/guidance/published?ndt=Guidance&ngt=Technology%20appraisal%20guidance&ps=9999">All</a></li></ol></div></div></section></div></div><div class="BackToTop_wrapper__lWIkB"><nav aria-labelledby="back-to-top-link" class="BackToTop_nav__PkXNm"><a class="BackToTop_anchor__D_DFc" id="back-to-top-link" href="#top"><div class="container BackToTop_container__eSpc_" data-component="container"><svg width="1em" height="1em" viewBox="0 0 512 512" fill="none" xmlns="http://www.w3.org/2000/svg" class="icon" aria-hidden="true" focusable="false"><path d="M478.152 338.576c0 10.091-3.525 18.661-10.576 25.712l-21.424 21.424c-7.243 7.243-15.909 10.864-26 10.864-10.283 0-18.853-3.621-25.712-10.864L255.576 247.136 116.712 385.712c-6.859 7.243-15.429 10.864-25.712 10.864s-18.853-3.621-25.712-10.864l-21.424-21.424C36.621 357.429 33 348.859 33 338.576c0-10.091 3.621-18.757 10.864-26l186-186c7.051-7.051 15.621-10.576 25.712-10.576 9.909 0 18.576 3.525 26 10.576l185.712 186c7.243 7.243 10.864 15.909 10.864 26Z" fill="currentColor"></path></svg> Back to top</div></a></nav></div></main><noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-M55QTQ" height="0" width="0" style="display:none"></iframe></noscript><footer class="Footer_footer___AIsg" data-tracking="Global footer"><div class="Footer_container__r0Ib_"><a href="https://www.nice.org.uk/" class="Footer_logo__pKuR2" aria-label="Go to NICE home page"><svg width="1em" height="1em" viewBox="0 0 1381 512" fill="none" xmlns="http://www.w3.org/2000/svg" class="icon" aria-hidden="true" focusable="false"><path d="M396.692 37.908v436.036h-79.615L127.42 199.501h-3.25v274.443H32V37.908h80.944l188.181 274.295h3.84V37.908h91.727ZM552.082 37.908h-92.17v436.036h92.17V37.908ZM1000.08 190.639h-93.202c-1.773-12.112-5.17-22.747-10.488-32.2-5.317-9.454-11.964-17.43-20.236-24.225-8.271-6.647-17.725-11.816-28.36-15.361-10.782-3.545-22.304-5.318-34.859-5.318-22.599 0-42.245 5.613-58.936 16.691-16.691 11.078-29.689 27.326-38.995 48.596-9.158 21.27-13.884 46.972-13.884 77.252 0 30.28 4.579 57.163 13.884 78.285 9.306 21.123 22.304 37.075 38.995 47.858 16.691 10.783 36.189 16.1 58.198 16.1 12.407 0 23.781-1.625 34.416-4.874 10.635-3.25 19.94-7.976 28.212-14.328 8.272-6.351 15.066-14.032 20.531-23.042 5.466-9.011 9.306-19.498 11.374-31.019l93.204.443c-2.363 19.941-8.419 39.29-18.02 57.754-9.601 18.463-22.452 35.007-38.552 49.63-16.101 14.475-35.303 25.997-57.459 34.416C863.747 475.716 838.636 480 810.572 480c-38.848 0-73.559-8.863-104.135-26.44-30.575-17.577-54.652-43.131-72.377-76.365-17.725-33.382-26.588-73.707-26.588-121.121 0-47.415 9.011-88.034 26.883-121.417 17.873-33.382 42.097-58.788 72.821-76.365C737.899 40.715 772.315 32 810.572 32c25.258 0 48.744 3.545 70.309 10.635 21.713 7.09 40.915 17.43 57.606 31.019 16.691 13.589 30.428 30.132 40.916 49.778 10.635 19.645 17.281 41.949 20.383 67.207M1053.55 473.944V37.908h293.79v76.07h-201.62v103.839h186.56v76.07h-186.56v104.135h202.51v75.922h-294.68Z" fill="currentColor"></path></svg></a><nav class="Services_wrapper__xryL4" aria-label="Our services"><ul class="Services_list__GzZL_"><li><a href="https://www.nice.org.uk/guidance" class="Services_link__jcE9g">Guidance</a></li><li><a href="https://www.nice.org.uk/standards-and-indicators" class="Services_link__jcE9g">Standards and indicators</a></li><li><a href="https://www.nice.org.uk/about/what-we-do/life-sciences" class="Services_link__jcE9g">Life sciences</a></li><li><a href="https://bnf.nice.org.uk/" class="Services_link__jcE9g">British National Formulary (BNF)</a></li><li><a href="https://bnfc.nice.org.uk/" class="Services_link__jcE9g">British National Formulary for Children (BNFC)</a></li><li><a href="https://cks.nice.org.uk/" class="Services_link__jcE9g">Clinical Knowledge Summaries (CKS)</a></li><li><a href="https://www.nice.org.uk/about/what-we-do/evidence-services/journals-and-databases" class="Services_link__jcE9g">Knowledge resources</a></li></ul></nav><nav class="Pages_wrapper__CzYGw"><ul class="Pages_list__VPm2s"><li><a href="https://www.nice.org.uk/about">About NICE</a></li><li><a href="https://www.nice.org.uk/about/what-we-do/into-practice">Into practice</a></li><li><a href="https://www.nice.org.uk/get-involved">Get involved with NICE</a></li><li><a href="https://www.nice.org.uk/get-involved/jobs">Jobs</a></li><li><a href="https://www.nice.org.uk/news">News</a></li><li><a href="https://www.nice.org.uk/news/nice-newsletters-and-alerts">Newsletters and alerts</a></li><li><a href="https://www.nice.org.uk/get-involved/contact-us">Contact us</a></li><li><a href="https://www.nice.org.uk/forms/leave-feedback">Leave feedback</a></li><li><a href="https://www.nice.org.uk/re-using-our-content">Reusing our content</a></li><li><a href="https://www.nice.org.uk/forms/use-of-nice-content-in-the-uk">NICE UK Open Content Licence</a></li><li><a href="https://www.nice.org.uk/about/what-we-do/nice-syndication-api">Syndicate our content</a></li><li><a href="https://www.nice.org.uk/events">Events</a></li></ul></nav><div class="Social_wrapper__V3V_U"><ul class="Social_list__rfQom" aria-label="NICE on social media"><li><a href="https://en-gb.facebook.com/NationalInstituteforHealthandCareExcellence/"><svg width="1em" height="1em" viewBox="0 0 512 512" fill="none" xmlns="http://www.w3.org/2000/svg" class="icon" aria-hidden="true" focusable="false"><path d="M291.069 178.811H361l-8.168 77.197h-61.778V480h-92.789V256.008H152v-77.197h46.265V132.32c0-32.983 7.802-57.95 23.407-74.897C237.276 40.474 262.949 32 298.689 32h61.778v77.196h-38.646c-7.071 0-12.74.589-17.006 1.766-4.267 1.177-7.351 3.309-9.25 6.394-1.9 3.085-3.124 6.211-3.673 9.377-.549 3.167-.823 7.652-.823 13.457v38.621Z" fill="currentColor"></path></svg>Facebook</a></li><li><a href="https://x.com/NICEcomms"><svg width="1em" height="1em" viewBox="0 0 1200 1227" fill="none" xmlns="http://www.w3.org/2000/svg" class="icon" aria-hidden="true" focusable="false"><path d="M714.163 519.284 1160.89 0h-105.86L667.137 450.887 357.328 0H0l468.492 681.821L0 1226.37h105.866l409.625-476.152 327.181 476.152H1200L714.137 519.284h.026ZM569.165 687.828l-47.468-67.894-377.686-540.24h162.604l304.797 435.991 47.468 67.894 396.2 566.721H892.476L569.165 687.854v-.026Z" fill="currentColor"></path></svg>X</a></li><li><a href="https://www.youtube.com/user/NICEmedia"><svg width="1em" height="1em" viewBox="0 0 512 512" fill="none" xmlns="http://www.w3.org/2000/svg" class="icon" aria-hidden="true" focusable="false"><path d="M209.753 314.5 330.746 252l-120.993-63.25V314.5ZM256 99c27.998 0 55.039.375 81.12 1.125 26.082.75 45.206 1.542 57.372 2.375l18.249 1c.167 0 1.584.125 4.25.375 2.667.25 4.583.5 5.75.75 1.166.25 3.125.625 5.874 1.125 2.75.5 5.125 1.167 7.125 2s4.333 1.917 7 3.25a48.044 48.044 0 0 1 7.749 4.875c2.5 1.917 4.917 4.125 7.25 6.625 1 1 2.291 2.542 3.875 4.625 1.583 2.083 3.999 6.958 7.249 14.625 3.25 7.667 5.458 16.083 6.625 25.25 1.333 10.667 2.375 22.042 3.125 34.125.75 12.083 1.208 21.542 1.375 28.375v44a529.498 529.498 0 0 1-4.5 72.5c-1.167 9.167-3.25 17.458-6.25 24.875-3 7.417-5.666 12.542-7.999 15.375l-3.5 4.25c-2.333 2.5-4.75 4.708-7.25 6.625-2.5 1.917-5.083 3.5-7.749 4.75-2.667 1.25-5 2.292-7 3.125-2 .833-4.375 1.5-7.125 2-2.749.5-4.749.875-5.999 1.125s-3.167.5-5.75.75-3.958.375-4.125.375C370.91 412.417 318.663 414 256 414c-34.498-.333-64.455-.875-89.87-1.625-25.415-.75-42.123-1.375-50.122-1.875l-12.25-1-8.999-1c-6-.833-10.541-1.667-13.624-2.5s-7.333-2.583-12.75-5.25c-5.416-2.667-10.124-6.083-14.124-10.25-1-1-2.291-2.542-3.875-4.625-1.583-2.083-4-6.958-7.25-14.625-3.249-7.667-5.457-16.083-6.624-25.25-1.333-10.667-2.375-22.042-3.125-34.125-.75-12.083-1.208-21.542-1.374-28.375v-44a529.323 529.323 0 0 1 4.5-72.5c1.166-9.167 3.25-17.458 6.249-24.875 3-7.417 5.666-12.542 8-15.375l3.5-4.25c2.332-2.5 4.749-4.708 7.249-6.625A48.018 48.018 0 0 1 69.26 111c2.666-1.333 5-2.417 6.999-3.25 2-.833 4.375-1.5 7.125-2s4.708-.875 5.874-1.125c1.167-.25 3.084-.5 5.75-.75s4.083-.375 4.25-.375C141.09 100.5 193.337 99 256 99Z" fill="currentColor"></path></svg>YouTube</a></li><li><a href="https://www.linkedin.com/company/national-institute-for-health-and-clinical-excellence"><svg width="1em" height="1em" viewBox="0 0 512 512" fill="none" xmlns="http://www.w3.org/2000/svg" class="icon" aria-hidden="true" focusable="false"><path d="M134.024 181.394v289.59H37.565v-289.59h96.459Zm6.138-89.416c.196 14.226-4.725 26.112-14.764 35.658-10.039 9.546-23.243 14.319-39.612 14.319h-.589c-15.975 0-28.835-4.773-38.58-14.319C36.872 118.09 32 106.204 32 91.978c0-14.412 5.02-26.347 15.059-35.806C57.099 46.713 70.204 41.989 86.376 42c16.172.01 29.13 4.735 38.874 14.172 9.745 9.437 14.716 21.372 14.912 35.806Zm340.822 213.035V471H384.82V316.125c0-20.456-3.945-36.483-11.835-48.08-7.889-11.597-20.215-17.395-36.976-17.395-12.276 0-22.555 3.36-30.838 10.08-8.282 6.721-14.469 15.05-18.561 24.989-2.139 5.848-3.209 13.736-3.209 23.663v161.602h-96.164c.393-77.733.59-140.758.59-189.078 0-48.319-.099-77.154-.295-86.503l-.295-14.025h96.164v42.074h-.589c3.896-6.23 7.89-11.685 11.982-16.365 4.092-4.68 9.597-9.748 16.515-15.203 6.919-5.455 15.398-9.693 25.437-12.715 10.039-3.022 21.197-4.533 33.473-4.533 33.326 0 60.121 11.057 80.385 33.171C470.868 229.921 481 262.312 481 304.98l-.016.033Z" fill="currentColor"></path></svg>LinkedIn</a></li></ul></div></div><div class="Legal_wrapper__aXhHi"><div class="Legal_container__5nLdZ"><nav class="Legal_menu__L03tj" aria-label="Legal menu"><ul><li><a href="https://www.nice.org.uk/accessibility">Accessibility</a></li><li><a href="https://www.nice.org.uk/freedom-of-information">Freedom of information</a></li><li><a href="https://www.nice.org.uk/glossary">Glossary</a></li><li><a href="https://www.nice.org.uk/terms-and-conditions">Terms and conditions</a></li><li><a href="https://www.nice.org.uk/privacy-notice">Privacy notice</a></li><li><a href="https://www.nice.org.uk/cookies">Cookies</a></li></ul></nav><p class="Legal_copyright__Vn3GT">©<!-- --> <abbr title="National Institute for Health and Care Excellence">NICE</abbr> <!-- -->2024<!-- -->. All rights reserved. Subject to<!-- --> <a href="https://www.nice.org.uk/terms-and-conditions#notice-of-rights">Notice of rights</a>.</p></div></div></footer></div></div><script id="__NEXT_DATA__" type="application/json">{"props":{"pageProps":{"results":{"debug":null,"failed":false,"errorMessage":null,"parentResultUrl":null,"resultCount":797,"documents":[{"id":"2531155","tagsHigh":null,"guidanceRef":"TA1017","xml":null,"abstract":null,"metaDescription":null,"accredited":false,"alternativePublicationDate":null,"altSourceNames":["Guidance and advice list page published products"],"areaOfInterest":null,"breadcrumbs":null,"childDocumentCount":0,"childDocuments":[],"childDocumentsUrl":null,"clusterId":-2531155,"evidenceTypes":[],"headings":null,"impact":null,"content":null,"contentId":"https://www.nice.org.uk/guidance/ta1017","index":0,"lessSuitableForPrescribing":false,"niceDocType":["Guidance"],"niceGuidanceType":["Technology appraisal guidance"],"niceAdviceType":[],"niceResultType":null,"parentPathTitle":null,"parentPathUrl":null,"parentPathWayUrl":null,"pathAndQuery":"/guidance/ta1017","primaryDrug":null,"publicationDate":"2024-11-20T12:00:00","lastUpdated":"2024-11-20T12:00:00","expectedPublicationDate":null,"consultationEndDate":null,"topicSelectionDecisionDate":null,"consultationType":null,"resourceType":[],"guidanceStatus":["Published"],"publicationType":null,"publisher":null,"resourceCategory":null,"relatedLinks":null,"relatedLinkList":{},"technologyType":null,"topicSelectionDecision":null,"subject":null,"sourceName":"GuidanceAdviceListPagePublishedProducts","sourceUrl":"https://www.nice.org.uk/guidance/ta1017","staticAbstract":null,"subSectionLinks":null,"subSections":[],"summaryUrl":null,"tags":[],"teaser":"TA1017","title":"Pembrolizumab with chemotherapy before surgery (neoadjuvant) then alone after surgery (adjuvant) for treating resectable non-small-cell lung cancer","titleNoHtml":null,"boostValue":100,"score":null,"titleParts":["Pembrolizumab with chemotherapy before surgery (neoadjuvant) then alone after surgery (adjuvant) for treating resectable non-small-cell lung cancer"],"ukmiSummaryUrl":null,"url":"https://www.nice.org.uk/guidance/ta1017","debug":null},{"id":"2531156","tagsHigh":null,"guidanceRef":"TA1018","xml":null,"abstract":null,"metaDescription":null,"accredited":false,"alternativePublicationDate":null,"altSourceNames":["Guidance and advice list page published products"],"areaOfInterest":null,"breadcrumbs":null,"childDocumentCount":0,"childDocuments":[],"childDocumentsUrl":null,"clusterId":-2531156,"evidenceTypes":[],"headings":null,"impact":null,"content":null,"contentId":"https://www.nice.org.uk/guidance/ta1018","index":0,"lessSuitableForPrescribing":false,"niceDocType":["Guidance"],"niceGuidanceType":["Technology appraisal guidance"],"niceAdviceType":[],"niceResultType":null,"parentPathTitle":null,"parentPathUrl":null,"parentPathWayUrl":null,"pathAndQuery":"/guidance/ta1018","primaryDrug":null,"publicationDate":"2024-11-20T12:00:00","lastUpdated":"2024-11-20T12:00:00","expectedPublicationDate":null,"consultationEndDate":null,"topicSelectionDecisionDate":null,"consultationType":null,"resourceType":[],"guidanceStatus":["Published"],"publicationType":null,"publisher":null,"resourceCategory":null,"relatedLinks":null,"relatedLinkList":{},"technologyType":null,"topicSelectionDecision":null,"subject":null,"sourceName":"GuidanceAdviceListPagePublishedProducts","sourceUrl":"https://www.nice.org.uk/guidance/ta1018","staticAbstract":null,"subSectionLinks":null,"subSections":[],"summaryUrl":null,"tags":[],"teaser":"TA1018","title":"Fedratinib for treating disease-related splenomegaly or symptoms in myelofibrosis","titleNoHtml":null,"boostValue":100,"score":null,"titleParts":["Fedratinib for treating disease-related splenomegaly or symptoms in myelofibrosis"],"ukmiSummaryUrl":null,"url":"https://www.nice.org.uk/guidance/ta1018","debug":null},{"id":"2531158","tagsHigh":null,"guidanceRef":"TA1019","xml":null,"abstract":null,"metaDescription":null,"accredited":false,"alternativePublicationDate":null,"altSourceNames":["Guidance and advice list page published products"],"areaOfInterest":null,"breadcrumbs":null,"childDocumentCount":0,"childDocuments":[],"childDocumentsUrl":null,"clusterId":-2531158,"evidenceTypes":[],"headings":null,"impact":null,"content":null,"contentId":"https://www.nice.org.uk/guidance/ta1019","index":0,"lessSuitableForPrescribing":false,"niceDocType":["Guidance"],"niceGuidanceType":["Technology appraisal guidance"],"niceAdviceType":[],"niceResultType":null,"parentPathTitle":null,"parentPathUrl":null,"parentPathWayUrl":null,"pathAndQuery":"/guidance/ta1019","primaryDrug":null,"publicationDate":"2024-11-20T12:00:00","lastUpdated":"2024-11-20T12:00:00","expectedPublicationDate":null,"consultationEndDate":null,"topicSelectionDecisionDate":null,"consultationType":null,"resourceType":[],"guidanceStatus":["Published"],"publicationType":null,"publisher":null,"resourceCategory":null,"relatedLinks":null,"relatedLinkList":{},"technologyType":null,"topicSelectionDecision":null,"subject":null,"sourceName":"GuidanceAdviceListPagePublishedProducts","sourceUrl":"https://www.nice.org.uk/guidance/ta1019","staticAbstract":null,"subSectionLinks":null,"subSections":[],"summaryUrl":null,"tags":[],"teaser":"TA1019","title":"Crovalimab for treating paroxysmal nocturnal haemoglobinuria in people 12 years and over","titleNoHtml":null,"boostValue":100,"score":null,"titleParts":["Crovalimab for treating paroxysmal nocturnal haemoglobinuria in people 12 years and over"],"ukmiSummaryUrl":null,"url":"https://www.nice.org.uk/guidance/ta1019","debug":null},{"id":"2530334","tagsHigh":null,"guidanceRef":"TA1016","xml":null,"abstract":null,"metaDescription":null,"accredited":false,"alternativePublicationDate":null,"altSourceNames":["Guidance and advice list page published products"],"areaOfInterest":null,"breadcrumbs":null,"childDocumentCount":0,"childDocuments":[],"childDocumentsUrl":null,"clusterId":-2530334,"evidenceTypes":[],"headings":null,"impact":null,"content":null,"contentId":"https://www.nice.org.uk/guidance/ta1016","index":0,"lessSuitableForPrescribing":false,"niceDocType":["Guidance"],"niceGuidanceType":["Technology appraisal guidance"],"niceAdviceType":[],"niceResultType":null,"parentPathTitle":null,"parentPathUrl":null,"parentPathWayUrl":null,"pathAndQuery":"/guidance/ta1016","primaryDrug":null,"publicationDate":"2024-11-14T12:00:00","lastUpdated":"2024-11-14T12:00:00","expectedPublicationDate":null,"consultationEndDate":null,"topicSelectionDecisionDate":null,"consultationType":null,"resourceType":[],"guidanceStatus":["Published"],"publicationType":null,"publisher":null,"resourceCategory":null,"relatedLinks":null,"relatedLinkList":{},"technologyType":null,"topicSelectionDecision":null,"subject":null,"sourceName":"GuidanceAdviceListPagePublishedProducts","sourceUrl":"https://www.nice.org.uk/guidance/ta1016","staticAbstract":null,"subSectionLinks":null,"subSections":[],"summaryUrl":null,"tags":[],"teaser":"TA1016","title":"Elafibranor for previously treated primary biliary cholangitis","titleNoHtml":null,"boostValue":100,"score":null,"titleParts":["Elafibranor for previously treated primary biliary cholangitis"],"ukmiSummaryUrl":null,"url":"https://www.nice.org.uk/guidance/ta1016","debug":null},{"id":"2530276","tagsHigh":null,"guidanceRef":"TA1014","xml":null,"abstract":null,"metaDescription":null,"accredited":false,"alternativePublicationDate":null,"altSourceNames":["Guidance and advice list page published products"],"areaOfInterest":null,"breadcrumbs":null,"childDocumentCount":0,"childDocuments":[],"childDocumentsUrl":null,"clusterId":-2530276,"evidenceTypes":[],"headings":null,"impact":null,"content":null,"contentId":"https://www.nice.org.uk/guidance/ta1014","index":0,"lessSuitableForPrescribing":false,"niceDocType":["Guidance"],"niceGuidanceType":["Technology appraisal guidance"],"niceAdviceType":[],"niceResultType":null,"parentPathTitle":null,"parentPathUrl":null,"parentPathWayUrl":null,"pathAndQuery":"/guidance/ta1014","primaryDrug":null,"publicationDate":"2024-11-13T12:00:00","lastUpdated":"2024-11-13T12:00:00","expectedPublicationDate":null,"consultationEndDate":null,"topicSelectionDecisionDate":null,"consultationType":null,"resourceType":[],"guidanceStatus":["Published"],"publicationType":null,"publisher":null,"resourceCategory":null,"relatedLinks":null,"relatedLinkList":{},"technologyType":null,"topicSelectionDecision":null,"subject":null,"sourceName":"GuidanceAdviceListPagePublishedProducts","sourceUrl":"https://www.nice.org.uk/guidance/ta1014","staticAbstract":null,"subSectionLinks":null,"subSections":[],"summaryUrl":null,"tags":[],"teaser":"TA1014","title":"Alectinib for adjuvant treatment of ALK-positive non-small-cell lung cancer","titleNoHtml":null,"boostValue":100,"score":null,"titleParts":["Alectinib for adjuvant treatment of ALK-positive non-small-cell lung cancer"],"ukmiSummaryUrl":null,"url":"https://www.nice.org.uk/guidance/ta1014","debug":null},{"id":"2530277","tagsHigh":null,"guidanceRef":"TA1015","xml":null,"abstract":null,"metaDescription":null,"accredited":false,"alternativePublicationDate":null,"altSourceNames":["Guidance and advice list page published products"],"areaOfInterest":null,"breadcrumbs":null,"childDocumentCount":0,"childDocuments":[],"childDocumentsUrl":null,"clusterId":-2530277,"evidenceTypes":[],"headings":null,"impact":null,"content":null,"contentId":"https://www.nice.org.uk/guidance/ta1015","index":0,"lessSuitableForPrescribing":false,"niceDocType":["Guidance"],"niceGuidanceType":["Technology appraisal guidance"],"niceAdviceType":[],"niceResultType":null,"parentPathTitle":null,"parentPathUrl":null,"parentPathWayUrl":null,"pathAndQuery":"/guidance/ta1015","primaryDrug":null,"publicationDate":"2024-11-13T12:00:00","lastUpdated":"2024-11-13T12:00:00","expectedPublicationDate":null,"consultationEndDate":null,"topicSelectionDecisionDate":null,"consultationType":null,"resourceType":[],"guidanceStatus":["Published"],"publicationType":null,"publisher":null,"resourceCategory":null,"relatedLinks":null,"relatedLinkList":{},"technologyType":null,"topicSelectionDecision":null,"subject":null,"sourceName":"GuidanceAdviceListPagePublishedProducts","sourceUrl":"https://www.nice.org.uk/guidance/ta1015","staticAbstract":null,"subSectionLinks":null,"subSections":[],"summaryUrl":null,"tags":[],"teaser":"TA1015","title":"Teclistamab for treating relapsed and refractory multiple myeloma after 3 or more treatments","titleNoHtml":null,"boostValue":100,"score":null,"titleParts":["Teclistamab for treating relapsed and refractory multiple myeloma after 3 or more treatments"],"ukmiSummaryUrl":null,"url":"https://www.nice.org.uk/guidance/ta1015","debug":null},{"id":"2529799","tagsHigh":null,"guidanceRef":"TA1012","xml":null,"abstract":null,"metaDescription":null,"accredited":false,"alternativePublicationDate":null,"altSourceNames":["Guidance and advice list page published products"],"areaOfInterest":null,"breadcrumbs":null,"childDocumentCount":0,"childDocuments":[],"childDocumentsUrl":null,"clusterId":-2529799,"evidenceTypes":[],"headings":null,"impact":null,"content":null,"contentId":"https://www.nice.org.uk/guidance/ta1012","index":0,"lessSuitableForPrescribing":false,"niceDocType":["Guidance"],"niceGuidanceType":["Technology appraisal guidance"],"niceAdviceType":[],"niceResultType":null,"parentPathTitle":null,"parentPathUrl":null,"parentPathWayUrl":null,"pathAndQuery":"/guidance/ta1012","primaryDrug":null,"publicationDate":"2024-11-06T12:00:00","lastUpdated":"2024-11-06T12:00:00","expectedPublicationDate":null,"consultationEndDate":null,"topicSelectionDecisionDate":null,"consultationType":null,"resourceType":[],"guidanceStatus":["Published"],"publicationType":null,"publisher":null,"resourceCategory":null,"relatedLinks":null,"relatedLinkList":{},"technologyType":null,"topicSelectionDecision":null,"subject":null,"sourceName":"GuidanceAdviceListPagePublishedProducts","sourceUrl":"https://www.nice.org.uk/guidance/ta1012","staticAbstract":null,"subSectionLinks":null,"subSections":[],"summaryUrl":null,"tags":[],"teaser":"TA1012","title":"Avapritinib for treating advanced systemic mastocytosis","titleNoHtml":null,"boostValue":100,"score":null,"titleParts":["Avapritinib for treating advanced systemic mastocytosis"],"ukmiSummaryUrl":null,"url":"https://www.nice.org.uk/guidance/ta1012","debug":null},{"id":"2529606","tagsHigh":null,"guidanceRef":"TA1010","xml":null,"abstract":null,"metaDescription":null,"accredited":false,"alternativePublicationDate":null,"altSourceNames":["Guidance and advice list page published products"],"areaOfInterest":null,"breadcrumbs":null,"childDocumentCount":0,"childDocuments":[],"childDocumentsUrl":null,"clusterId":-2529606,"evidenceTypes":[],"headings":null,"impact":null,"content":null,"contentId":"https://www.nice.org.uk/guidance/ta1010","index":0,"lessSuitableForPrescribing":false,"niceDocType":["Guidance"],"niceGuidanceType":["Technology appraisal guidance"],"niceAdviceType":[],"niceResultType":null,"parentPathTitle":null,"parentPathUrl":null,"parentPathWayUrl":null,"pathAndQuery":"/guidance/ta1010","primaryDrug":null,"publicationDate":"2024-10-23T12:00:00","lastUpdated":"2024-10-23T12:00:00","expectedPublicationDate":null,"consultationEndDate":null,"topicSelectionDecisionDate":null,"consultationType":null,"resourceType":[],"guidanceStatus":["Published"],"publicationType":null,"publisher":null,"resourceCategory":null,"relatedLinks":null,"relatedLinkList":{},"technologyType":null,"topicSelectionDecision":null,"subject":null,"sourceName":"GuidanceAdviceListPagePublishedProducts","sourceUrl":"https://www.nice.org.uk/guidance/ta1010","staticAbstract":null,"subSectionLinks":null,"subSections":[],"summaryUrl":null,"tags":[],"teaser":"TA1010","title":"Danicopan with ravulizumab or eculizumab for treating paroxysmal nocturnal haemoglobinuria","titleNoHtml":null,"boostValue":100,"score":null,"titleParts":["Danicopan with ravulizumab or eculizumab for treating paroxysmal nocturnal haemoglobinuria"],"ukmiSummaryUrl":null,"url":"https://www.nice.org.uk/guidance/ta1010","debug":null},{"id":"2529607","tagsHigh":null,"guidanceRef":"TA1013","xml":null,"abstract":null,"metaDescription":null,"accredited":false,"alternativePublicationDate":null,"altSourceNames":["Guidance and advice list page published products"],"areaOfInterest":null,"breadcrumbs":null,"childDocumentCount":0,"childDocuments":[],"childDocumentsUrl":null,"clusterId":-2529607,"evidenceTypes":[],"headings":null,"impact":null,"content":null,"contentId":"https://www.nice.org.uk/guidance/ta1013","index":0,"lessSuitableForPrescribing":false,"niceDocType":["Guidance"],"niceGuidanceType":["Technology appraisal guidance"],"niceAdviceType":[],"niceResultType":null,"parentPathTitle":null,"parentPathUrl":null,"parentPathWayUrl":null,"pathAndQuery":"/guidance/ta1013","primaryDrug":null,"publicationDate":"2024-10-23T12:00:00","lastUpdated":"2024-10-23T12:00:00","expectedPublicationDate":null,"consultationEndDate":null,"topicSelectionDecisionDate":null,"consultationType":null,"resourceType":[],"guidanceStatus":["Published"],"publicationType":null,"publisher":null,"resourceCategory":null,"relatedLinks":null,"relatedLinkList":{},"technologyType":null,"topicSelectionDecision":null,"subject":null,"sourceName":"GuidanceAdviceListPagePublishedProducts","sourceUrl":"https://www.nice.org.uk/guidance/ta1013","staticAbstract":null,"subSectionLinks":null,"subSections":[],"summaryUrl":null,"tags":[],"teaser":"TA1013","title":"Quizartinib for induction, consolidation and maintenance treatment of newly diagnosed FLT3-ITD-positive acute myeloid leukaemia","titleNoHtml":null,"boostValue":100,"score":null,"titleParts":["Quizartinib for induction, consolidation and maintenance treatment of newly diagnosed FLT3-ITD-positive acute myeloid leukaemia"],"ukmiSummaryUrl":null,"url":"https://www.nice.org.uk/guidance/ta1013","debug":null},{"id":"2529425","tagsHigh":null,"guidanceRef":"TA1011","xml":null,"abstract":null,"metaDescription":null,"accredited":false,"alternativePublicationDate":null,"altSourceNames":["Guidance and advice list page published products"],"areaOfInterest":null,"breadcrumbs":null,"childDocumentCount":0,"childDocuments":[],"childDocumentsUrl":null,"clusterId":-2529425,"evidenceTypes":[],"headings":null,"impact":null,"content":null,"contentId":"https://www.nice.org.uk/guidance/ta1011","index":0,"lessSuitableForPrescribing":false,"niceDocType":["Guidance"],"niceGuidanceType":["Technology appraisal guidance"],"niceAdviceType":[],"niceResultType":null,"parentPathTitle":null,"parentPathUrl":null,"parentPathWayUrl":null,"pathAndQuery":"/guidance/ta1011","primaryDrug":null,"publicationDate":"2024-10-16T12:00:00","lastUpdated":"2024-10-16T12:00:00","expectedPublicationDate":null,"consultationEndDate":null,"topicSelectionDecisionDate":null,"consultationType":null,"resourceType":[],"guidanceStatus":["Published"],"publicationType":null,"publisher":null,"resourceCategory":null,"relatedLinks":null,"relatedLinkList":{},"technologyType":null,"topicSelectionDecision":null,"subject":null,"sourceName":"GuidanceAdviceListPagePublishedProducts","sourceUrl":"https://www.nice.org.uk/guidance/ta1011","staticAbstract":null,"subSectionLinks":null,"subSections":[],"summaryUrl":null,"tags":[],"teaser":"TA1011","title":"Belzutifan for treating tumours associated with von Hippel-Lindau disease","titleNoHtml":null,"boostValue":100,"score":null,"titleParts":["Belzutifan for treating tumours associated with von Hippel-Lindau disease"],"ukmiSummaryUrl":null,"url":"https://www.nice.org.uk/guidance/ta1011","debug":null}],"pagerLinks":{"previous":null,"first":null,"pages":[{"title":"1","url":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?pa=1\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"gst\":[\"Published\"]}]","pa":1,"ps":10,"pt":null,"pbu":null,"q":null,"rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":null,"spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"isCurrent":true},{"title":"2","url":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?pa=2\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"gst\":[\"Published\"]}]","pa":2,"ps":10,"pt":null,"pbu":null,"q":null,"rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":null,"spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"isCurrent":false},{"title":"3","url":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?pa=3\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"gst\":[\"Published\"]}]","pa":3,"ps":10,"pt":null,"pbu":null,"q":null,"rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":null,"spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"isCurrent":false},{"title":"4","url":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?pa=4\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"gst\":[\"Published\"]}]","pa":4,"ps":10,"pt":null,"pbu":null,"q":null,"rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":null,"spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"isCurrent":false},{"title":"5","url":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?pa=5\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"gst\":[\"Published\"]}]","pa":5,"ps":10,"pt":null,"pbu":null,"q":null,"rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":null,"spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"isCurrent":false},{"title":"6","url":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?pa=6\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"gst\":[\"Published\"]}]","pa":6,"ps":10,"pt":null,"pbu":null,"q":null,"rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":null,"spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"isCurrent":false},{"title":"7","url":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?pa=7\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"gst\":[\"Published\"]}]","pa":7,"ps":10,"pt":null,"pbu":null,"q":null,"rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":null,"spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"isCurrent":false}],"next":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?pa=2\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"gst\":[\"Published\"]}]","pa":2,"ps":10,"pt":null,"pbu":null,"q":null,"rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":null,"spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"}},"pageSize":10,"firstResult":1,"lastResult":10,"finalSearchText":"","finalSearchTextNoStopWords":"","originalSearch":null,"navigators":[{"displayName":"Type","shortName":"ndt","modifiers":[{"active":true,"displayName":"Guidance","excluding":false,"navigatorShortName":"ndt","resultCount":797,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026ngt=Technology%20appraisal%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"ngt\":[\"Technology appraisal guidance\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null}]},{"displayName":"Guidance programme","shortName":"ngt","modifiers":[{"active":false,"displayName":"Antimicrobial prescribing guidelines","excluding":false,"navigatorShortName":"ngt","resultCount":20,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance\u0026ngt=Antimicrobial%20prescribing%20guidelines","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"ngt\":[\"Antimicrobial prescribing guidelines\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null},{"active":false,"displayName":"Cancer service guidelines","excluding":false,"navigatorShortName":"ngt","resultCount":8,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance\u0026ngt=Cancer%20service%20guidelines","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"ngt\":[\"Cancer service guidelines\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null},{"active":false,"displayName":"Clinical guidelines","excluding":false,"navigatorShortName":"ngt","resultCount":225,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance\u0026ngt=Clinical%20guidelines","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"ngt\":[\"Clinical guidelines\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null},{"active":false,"displayName":"COVID-19 rapid guidelines","excluding":false,"navigatorShortName":"ngt","resultCount":3,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance\u0026ngt=COVID-19%20rapid%20guidelines","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"ngt\":[\"COVID-19 rapid guidelines\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null},{"active":false,"displayName":"Diagnostics guidance","excluding":false,"navigatorShortName":"ngt","resultCount":50,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance\u0026ngt=Diagnostics%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"ngt\":[\"Diagnostics guidance\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null},{"active":false,"displayName":"Health technology evaluations","excluding":false,"navigatorShortName":"ngt","resultCount":18,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance\u0026ngt=Health%20technology%20evaluations","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"ngt\":[\"Health technology evaluations\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null},{"active":false,"displayName":"Highly specialised technologies guidance","excluding":false,"navigatorShortName":"ngt","resultCount":28,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance\u0026ngt=Highly%20specialised%20technologies%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"ngt\":[\"Highly specialised technologies guidance\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null},{"active":false,"displayName":"Interventional procedures guidance","excluding":false,"navigatorShortName":"ngt","resultCount":603,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance\u0026ngt=Interventional%20procedures%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"ngt\":[\"Interventional procedures guidance\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null},{"active":false,"displayName":"Medical technologies guidance","excluding":false,"navigatorShortName":"ngt","resultCount":67,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance\u0026ngt=Medical%20technologies%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"ngt\":[\"Medical technologies guidance\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null},{"active":false,"displayName":"Medicines practice guidelines","excluding":false,"navigatorShortName":"ngt","resultCount":5,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance\u0026ngt=Medicines%20practice%20guidelines","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"ngt\":[\"Medicines practice guidelines\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null},{"active":false,"displayName":"NICE guidelines","excluding":false,"navigatorShortName":"ngt","resultCount":341,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance\u0026ngt=NICE%20guidelines","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"ngt\":[\"NICE guidelines\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null},{"active":false,"displayName":"Public health guidelines","excluding":false,"navigatorShortName":"ngt","resultCount":61,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance\u0026ngt=Public%20health%20guidelines","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"ngt\":[\"Public health guidelines\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null},{"active":false,"displayName":"Safe staffing guidelines","excluding":false,"navigatorShortName":"ngt","resultCount":2,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance\u0026ngt=Safe%20staffing%20guidelines","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"ngt\":[\"Safe staffing guidelines\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null},{"active":false,"displayName":"Social care guidelines","excluding":false,"navigatorShortName":"ngt","resultCount":71,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance\u0026ngt=Social%20care%20guidelines","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]},{\"ngt\":[\"Social care guidelines\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null},{"active":true,"displayName":"Technology appraisal guidance","excluding":false,"navigatorShortName":"ngt","resultCount":797,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026ndt=Guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"ndt\":[\"Guidance\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null}]},{"displayName":"Status","shortName":"gst","modifiers":[{"active":true,"displayName":"Published","excluding":false,"navigatorShortName":"gst","resultCount":797,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null},{"active":false,"displayName":"In development","excluding":false,"navigatorShortName":"gst","resultCount":303,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026gst=In%20development\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"gst\":[\"In development\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null},{"active":false,"displayName":"Awaiting development","excluding":false,"navigatorShortName":"gst","resultCount":285,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026gst=Awaiting%20development\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"gst\":[\"Awaiting development\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null},{"active":false,"displayName":"In consultation","excluding":false,"navigatorShortName":"gst","resultCount":3,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026gst=In%20consultation\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"gst\":[\"In consultation\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null}]},{"displayName":"Area of interest","shortName":"nai","modifiers":[{"active":false,"displayName":"COVID-19","excluding":false,"navigatorShortName":"nai","resultCount":3,"toggleUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on\u0026nai=COVID-19\u0026ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance","fullUrlWithDefaultRoot":"","m":null,"om":"[{\"gst\":[\"Published\"]},{\"nai\":[\"COVID-19\"]},{\"ndt\":[\"Guidance\"]},{\"ngt\":[\"Technology appraisal guidance\"]}]","pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"},"childNavigators":null}]}],"unfilteredResultsUrl":{"af":null,"am":null,"arms":null,"ci":null,"cid":null,"co":null,"em":null,"fc":null,"fd":null,"from":null,"fs":null,"fullUrl":"/guidance/published?sp=on","fullUrlWithDefaultRoot":"","m":null,"om":null,"pa":null,"ps":null,"pt":null,"pbu":null,"q":"","rf":null,"s":"Date","sa":null,"aggsOnly":null,"sm":null,"sn":null,"sp":"on","spuid":null,"sr":null,"ss":null,"syn":null,"t":null,"td":null,"title":null,"to":null,"report":null,"debug":null,"index":"guidance","route":"/guidance/published"}},"activeModifiers":[{"displayName":"Type: Guidance","toggleUrl":"/guidance/published?sp=on\u0026ngt=Technology%20appraisal%20guidance"},{"displayName":"Guidance programme: Technology appraisal guidance","toggleUrl":"/guidance/published?sp=on\u0026ndt=Guidance"}],"searchUrl":{"route":"/guidance/published","fullUrl":"/guidance/published?ndt=Guidance\u0026ngt=Technology%20appraisal%20guidance","ndt":"Guidance","ngt":"Technology appraisal guidance"}},"__N_SSP":true},"page":"/guidance/published","query":{"ndt":"Guidance","ngt":"Technology appraisal guidance"},"buildId":"nPtE9ZhzdAiprqYEkzKqu","runtimeConfig":{"buildNumber":"10.0.2148+r5C25139","environment":"live","authEnvironment":"live","baseURL":"https://www.nice.org.uk","cookieBannerScriptURL":"https://cdn.nice.org.uk/cookie-banner/cookie-banner.min.js","publicBaseURL":"","search":{"baseURL":"https://search-api.nice.org.uk/api"},"cacheControl":{"defaultCacheHeader":"public, s-max-age=300, max-age=120, stale-while-revalidate=1800"},"jotForm":{"baseURL":"https://nice.jotform.com"},"storyblok":{"accessToken":"rFI0YRpDyqZpxXvUhbJB3gtt","ocelotEndpoint":"https://next-web-api.nice.org.uk/storyblok","enableRootCatchAll":false},"denyRobots":false,"nodeConfigServerKey":"server","nodeConfigPublicKey":"public"},"isFallback":false,"isExperimentalCompile":false,"gssp":true,"scriptLoader":[]}</script></body></html>