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property="dc:title" content="Perera, Rushika, PhD" class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-picture field-type-image field-label-hidden"><div class="field-items"><div class="field-item even"><img typeof="foaf:Image" src="https://anatomy.ucsf.edu/sites/g/files/tkssra5891/f/styles/large/public/f_perera.jpg?itok=ePGTfCAB" width="220" height="220" alt="" /></div></div></div><div class="field field-name-field-title field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even">Associate Professor & Vice Chair, Department of Anatomy<br /> <br /> </div></div></div><div class="field field-name-field-research-overview field-type-text-with-summary field-label-above"><div class="field-label">Research Overview<span class="colon">:</span> </div><div class="field-items"><div class="field-item even"><p>Perera lab聽focuses on understanding how scavenging pathways such as autophagy and the lysosome - a degradative organelle - enables metabolic and cellular adaptation to stress and contributes to aggressive features of disease. Beyond mediating degradation of diverse macromolecules, the lysosome also plays an important role in signal transduction, cellular quality control, metabolism and detoxification.聽The lab has a particular interest in how the lysosome contributes to cancer pathogenesis with a current focus on studying pancreatic ductal adenocarcinoma (PDA). The lab prior studies have identified novel mechanisms mediating constitutive activation of the MiT/TFE family of transcription factors which regulate autophagy and lysosome biogenesis in PDA聽and in normal physiological contexts. Perera lab has聽also discovered new roles for autophagy and the lysosome in facilitating immune evasion and enhanced metabolic fitness of PDA cells. The lab聽ongoing research leverages their combined experience in cellular trafficking, autophagy and lysosome function combined with in vitro and in vivo model systems, organelle isolation and mass spectrometry-based proteomics to determine critical roles of the lysosome in cancer progression and metastasis, tumor heterogeneity, stress adaptation and drug resistance.</p> <p>聽<a href="http://www.rushikapereralab.com/">Visit the Perera Lab</a></p> </div></div></div><div class="field field-name-field-contact-info field-type-text-long field-label-above"><div class="field-label">Contact Info<span class="colon">:</span> </div><div class="field-items"><div class="field-item even"><a href="/cdn-cgi/l/email-protection#7a080f091213111b540a1f081f081b3a0f19091c541f1e0f"><span class="__cf_email__" data-cfemail="8efcfbfde6e7e5efa0feebfcebfcefcefbedfde8a0ebeafb">[email protected]</span></a><br /> 513 Parnassus Ave, Room HSW 1321, Box 0452<br /> San Francisco, CA 94143<br /> 415-502-0706<br /> <br /> </div></div></div><div class="field field-name-field-ucsf-profile field-type-link-field field-label-hidden"><div class="field-items"><div class="field-item even"><a href="https://profiles.ucsf.edu/rushika.perera#toc-id1" target="_blank">UCSF Profile</a></div></div></div> </div> </div> </div> </div> </div> </div> </div> <div id="sidebar" class="column"> </div> </div></div> <div id="footer"> <div class="section"> <div class="footer-bottom"> <nav aria-label="Footer Navigation" class="footer--navigation"> <ul> <li><a href="https://anatomy.ucsf.edu/department-administration">Contact Us</a></li> <li><a href="https://www.ucsf.edu/accessibility-resources">Accessibility</a></li> <li><a href="https://www.ucsf.edu/website-privacy-policy">Privacy Policy</a></li> <li><a href="https://websites.ucsf.edu/website-terms-use">Terms of Use </a></li> <li><a href="https://websites.ucsf.edu/azlist">A-Z Website List</a></li> </ul> </nav> <div class="footer--copyright"> <p>© 2024 The Regents of the University of California</p> </div> </div> </div> </div> </div> </div> <script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script><script type="text/javascript"> /*<![CDATA[*/ (function() { var sz = document.createElement('script'); sz.type = 'text/javascript'; sz.async = true; sz.src = '//siteimproveanalytics.com/js/siteanalyze_8343.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(sz, s); })(); /*]]>*/ </script> </body> </html>