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<!DOCTYPE html> <html lang="en" dir="ltr" xmlns="http://www.w3.org/1999/xhtml" xmlns:mml="http://www.w3.org/1998/Math/MathML"> <head prefix="og: http://ogp.me/ns# article: http://ogp.me/ns/article# book: http://ogp.me/ns/book#" >  <link rel="dns-prefetch" href="//d33xdlntwy0kbs.cloudfront.net" /> <link rel="dns-prefetch" href="//cdn.jsdelivr.net" /> <link rel="dns-prefetch" href="//www.google.com" /> <link rel="dns-prefetch" href="//scholar.google.com" /> <link rel="dns-prefetch" href="//www.googletagmanager.com" /> <link rel="dns-prefetch" href="//rum-static.pingdom.net" /> <meta http-equiv="Content-Type" content="text/html; charset=utf-8" /> <link rel="shortcut icon" href="https://www.medrxiv.org/sites/default/files/images/favicon.ico" type="image/vnd.microsoft.icon" /> <meta name="viewport" content="width=device-width, initial-scale=1" /> <meta name="type" content="article" /> <meta name="category" content="article" /> <meta name="HW.identifier" content="/medrxiv/early/2024/11/07/2024.11.06.24316844.atom" /> <meta name="HW.pisa" content="medrxiv;2024.11.06.24316844v1" /> <meta name="DC.Format" content="text/html" /> <meta name="DC.Language" content="en" /> <meta name="DC.Title" content="Assessing infant risk of cerebral palsy with video-based motion tracking" /> <meta name="DC.Identifier" content="10.1101/2024.11.06.24316844" /> <meta name="DC.Date" content="2024-11-07" /> <meta name="DC.Publisher" content="Cold Spring Harbor Laboratory Press" /> <meta name="DC.Rights" content="© 2024, Posted by Cold Spring Harbor Laboratory. This pre-print is available under a Creative Commons License (Attribution-NonCommercial-NoDerivs 4.0 International), CC BY-NC-ND 4.0, as described at http://creativecommons.org/licenses/by-nc-nd/4.0/" /> <meta name="DC.AccessRights" content="restricted" /> <meta name="DC.Description" content="Cerebral Palsy (CP) is a common (about 1 in 500 children) health condition caused by abnormal brain development that affects the ability to control movement. Early risk assessment happens through the General Movements Assessment (GMA), a test administered by trained clinicians at 3-4 months of age that has high predictive value for CP. With recent improvements in video-based motion tracking, automated risk assessment for CP based on the GMA is being explored. However, studies generally have used small datasets or were limited in terms of methodological rigor. Here we acquired a large dataset (1060 infants) of videos from a clinical population with elevated CP risk. In a preregistered pipeline using a lock-box set that was not used before algorithm submission we find that our machine learning predictions are highly predictive of the clinician-assessed GMA (AUC=0.79). Given its low cost, our video-based approach may be useful for clinical screening applications, particularly in low-resource settings. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This work was funded by NIH-NICHD and the clinical early detection trial data collection was supported in part by the Cerebral Palsy Foundation ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Ethics committee/IRB of The University of Pennsylvania (Penn) gave ethical approval for this work I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All data that is consented for sharing (movement features and trained model) are available online at the OSF pre-registration site (<https://osf.io/sd6fa>) <https://osf.io/sd6fa> <https://doi.org/10.5281/zenodo.14042732>" /> <meta name="DC.Contributor" content="Melanie Segado" /> <meta name="DC.Contributor" content="Laura Prosser" /> <meta name="DC.Contributor" content="Andrea F. Duncan" /> <meta name="DC.Contributor" content="Michelle J. Johnson" /> <meta name="DC.Contributor" content="Konrad P. Kording" /> <meta name="article:published_time" content="2024-11-07" /> <meta name="citation_title" content="Assessing infant risk of cerebral palsy with video-based motion tracking" /> <meta name="citation_abstract" lang="en" content="<p>Cerebral Palsy (CP) is a common (about 1 in 500 children) health condition caused by abnormal brain development that affects the ability to control movement. Early risk assessment happens through the General Movements Assessment (GMA), a test administered by trained clinicians at 3-4 months of age that has high predictive value for CP. With recent improvements in video-based motion tracking, automated risk assessment for CP based on the GMA is being explored. However, studies generally have used small datasets or were limited in terms of methodological rigor. Here we acquired a large dataset (1060 infants) of videos from a clinical population with elevated CP risk. In a preregistered pipeline using a lock-box set that was not used before algorithm submission we find that our machine learning predictions are highly predictive of the clinician-assessed GMA (AUC=0.79). Given its low cost, our video-based approach may be useful for clinical screening applications, particularly in low-resource settings.</p>" /> <meta name="citation_journal_title" content="medRxiv" /> <meta name="citation_publisher" content="Cold Spring Harbor Laboratory Press" /> <meta name="citation_publication_date" content="2024/01/01" /> <meta name="citation_mjid" content="medrxiv;2024.11.06.24316844v1" /> <meta name="citation_id" content="2024.11.06.24316844v1" /> <meta name="citation_public_url" content="https://www.medrxiv.org/content/10.1101/2024.11.06.24316844v1" /> <meta name="citation_abstract_html_url" content="https://www.medrxiv.org/content/10.1101/2024.11.06.24316844v1.abstract" /> <meta name="citation_full_html_url" content="https://www.medrxiv.org/content/10.1101/2024.11.06.24316844v1.full" /> <meta name="citation_pdf_url" content="https://www.medrxiv.org/content/medrxiv/early/2024/11/07/2024.11.06.24316844.full.pdf" /> <meta name="citation_doi" content="10.1101/2024.11.06.24316844" /> <meta name="citation_num_pages" content="16" /> <meta name="citation_article_type" content="Article" /> <meta name="citation_firstpage" content="2024.11.06.24316844" /> <meta name="citation_author" content="Melanie Segado" /> <meta name="citation_author_institution" content="Department of Bioengineering, University of Pennsylvania" /> <meta name="citation_author_institution" content="Department of Neuroscience, University of Pennsylvania" /> <meta name="citation_author_institution" content="Division of Rehabilitation Medicine, The Children’s Hospital of Philadelphia" /> <meta name="citation_author_orcid" content="http://orcid.org/0000-0001-7862-6749" /> <meta name="citation_author" content="Laura Prosser" /> <meta name="citation_author_institution" content="Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania" /> <meta name="citation_author_institution" content="Division of Rehabilitation Medicine, The Children’s Hospital of Philadelphia" /> <meta name="citation_author_email" content="prosserl@chop.edu" /> <meta name="citation_author" content="Andrea F. Duncan" /> <meta name="citation_author_institution" content="Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania" /> <meta name="citation_author_institution" content="Division of Neonatology and Department of Pediatrics, Children’s Hospital of Philadelphia" /> <meta name="citation_author" content="Michelle J. Johnson" /> <meta name="citation_author_institution" content="Department of Bioengineering, University of Pennsylvania" /> <meta name="citation_author_institution" content="Department of Physical Medicine and Rehabilitation, University of Pennsylvania" /> <meta name="citation_author_institution" content="Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania" /> <meta name="citation_author_institution" content="Rehabilitation Robotics Lab, Perelman School of Medicine, University of Pennsylvania" /> <meta name="citation_author_orcid" content="http://orcid.org/0000-0002-7964-0304" /> <meta name="citation_author" content="Konrad P. Kording" /> <meta name="citation_author_institution" content="Department of Bioengineering, University of Pennsylvania" /> <meta name="citation_author_institution" content="Department of Neuroscience, University of Pennsylvania" /> <meta name="citation_author_orcid" content="http://orcid.org/0000-0001-8408-4499" /> <meta name="citation_reference" content="Sarah McIntyre, Goldsmith S, Webb A, et al. Global prevalence of cerebral palsy: A systematic analysis. Dev Med Child Neurol. 2022;64(12):1494–1506. doi:10.1111/dmcn.15346" /> <meta name="citation_reference" content="Novak I, Morgan C, Adde L, et al. Early, Accurate Diagnosis and Early Intervention in Cerebral Palsy: Advances in Diagnosis and Treatment. JAMA Pediatr. 2017;171(9):897–907. doi:10.1001/jamapediatrics.2017.1689" /> <meta name="citation_reference" content="Herskind A, Greisen G, Nielsen JB. Early identification and intervention in cerebral palsy. Dev Med Child Neurol. 2015;57(1):29–36. doi:10.1111/dmcn.12531" /> <meta name="citation_reference" content="Einspieler C, Prechtl HFR. Prechtl’s assessment of general movements: A diagnostic tool for the functional assessment of the young nervous system. Ment Retard Dev Disabil Res Rev. 2005;11(1):61–67. doi:10.1002/mrdd.20051" /> <meta name="citation_reference" content="Chambers C, Seethapathi N, Saluja R, et al. Computer Vision to Automatically Assess Infant Neuromotor Risk. IEEE Trans Neural Syst Rehabil Eng. 2020;28(11):2431–2442. doi:10.1109/TNSRE.2020.3029121" /> <meta name="citation_reference" content="Gao Q, Yao S, Tian Y, et al. Automating General Movements Assessment with quantitative deep learning to facilitate early screening of cerebral palsy. Nat Commun. 2023;14(1):8294. doi:10.1038/s41467-023-44141-x" /> <meta name="citation_reference" content="Adde L, Brown A, Broeck C van den, et al. In-Motion-App for remote General Movement Assessment: a multi-site observational study. BMJ Open. 2021;11(3):e042147. doi:10.1136/bmjopen-2020-042147" /> <meta name="citation_reference" content="Hashimoto Y, Furui A, Shimatani K, et al. Automated Classification of General Movements in Infants Using a Two-stream Spatiotemporal Fusion Network. Published online July 4, 2022. Accessed September 27, 2023. http://arxiv.org/abs/2207.03344" /> <meta name="citation_reference" content="Groos D, Adde L, Aubert S, et al. Development and Validation of a Deep Learning Method to Predict Cerebral Palsy From Spontaneous Movements in Infants at High Risk. JAMA Netw Open. 2022;5(7):e2221325. doi:10.1001/jamanetworkopen.2022.21325" /> <meta name="citation_reference" content="Irshad MT, Nisar MA, Gouverneur P, Rapp M, Grzegorzek M. AI Approaches towards Prechtl’s Assessment of General Movements: A Systematic Literature Review. Sensors. 2020;20(18):5321. doi:10.3390/s20185321" /> <meta name="citation_reference" content="Kwong AKL, Doyle LW, Olsen JE, et al. Parent-recorded videos of infant spontaneous movement: Comparisons at 3–4 months and relationships with 2-year developmental outcomes in extremely preterm, extremely low birthweight and term-born infants. Paediatr Perinat Epidemiol. 2022;36(5):673–682. doi:10.1111/ppe.12867" /> <meta name="citation_reference" content="Morais R, Le V, Morgan C, et al. Robust and Interpretable General Movement Assessment Using Fidgety Movement Detection. IEEE J Biomed Health Inform. Published online 2023:1–12. doi:10.1109/JBHI.2023.3299236" /> <meta name="citation_reference" content="Nguyen-Thai B, Le V, Morgan C, Badawi N, Tran T, Venkatesh S. A Spatio-temporal Attention-based Model for Infant Movement Assessment from Videos. IEEE J Biomed Health Inform. 2021;25(10):3911–3920. doi:10.1109/JBHI.2021.3077957" /> <meta name="citation_reference" content="Passmore E, Kwong AL, Greenstein S, et al. Automated identification of abnormal infant movements from smart phone videos. PLOS Digit Health. 2024;3(2):e0000432. doi:10.1371/journal.pdig.0000432" /> <meta name="citation_reference" content="Redd CB, Karunanithi M, Boyd RN, Barber LA. Technology-assisted quantification of movement to predict infants at high risk of motor disability: A systematic review. Res Dev Disabil. 2021;118:104071. doi:10.1016/j.ridd.2021.104071" /> <meta name="citation_reference" content="Silva N, Zhang D, Kulvicius T, et al. The future of General Movement Assessment: The role of computer vision and machine learning – A scoping review. Res Dev Disabil. 2021;110:103854. doi:10.1016/j.ridd.2021.103854" /> <meta name="citation_reference" content="Spittle AJ, Olsen J, Kwong A, et al. The Baby Moves prospective cohort study protocol: using a smartphone application with the General Movements Assessment to predict neurodevelopmental outcomes at age 2 years for extremely preterm or extremely low birthweight infants. BMJ Open. 2016;6(10):e013446. doi:10.1136/bmjopen-2016-013446" /> <meta name="citation_reference" content="Xu Y, Zhang J, Zhang Q, Tao D. ViTPose++: Vision Transformer for Generic Body Pose Estimation. Published online December 14, 2023. doi:10.48550/arXiv.2212.04246" /> <meta name="citation_reference" content="Liu W, Bao Q, Sun Y, Mei T. Recent Advances of Monocular 2D and 3D Human Pose Estimation: A Deep Learning Perspective. ACM Comput Surv. 2022;55(4):80:1-80:41. doi:10.1145/3524497" /> <meta name="citation_reference" content="Wei K, Kording KP. Behavioral tracking gets real. Nat Neurosci. 2018;21(9):1146–1147. doi:10.1038/s41593-018-0215-0" /> <meta name="citation_reference" content="Seethapathi N, Wang S, Saluja R, Blohm G, Kording KP. Movement science needs different pose tracking algorithms. Published online July 23, 2019. doi:10.48550/arXiv.1907.10226" /> <meta name="citation_reference" content="Hesse N, Bodensteiner C, Arens M, Hofmann UG, Weinberger R, Schroeder AS. Computer Vision for Medical Infant Motion Analysis: State of the Art and RGB-D Data Set. In: Computer Vision - ECCV 2018 Workshops. Springer International Publishing; 2018." /> <meta name="citation_reference" content="Ostadabbas S. Fine-tuned Domain-adapted Infant Pose (FiDIP). Published online August 17, 2023. Accessed September 6, 2023. https://github.com/ostadabbas/Infant-Pose-Estimation" /> <meta name="citation_reference" content="MMPose Contributors. OpenMMLab Pose Estimation Toolbox and Benchmark. Published online August 2020. https://github.com/open-mmlab/mmpose" /> <meta name="citation_reference" content="MMDetection Contributors. OpenMMLab Detection Toolbox and Benchmark. Published online August 2018. https://github.com/open-mmlab/mmdetection" /> <meta name="citation_reference" content="Ihlen EAF, Støen R, Boswell L, et al. Machine Learning of Infant Spontaneous Movements for the Early Prediction of Cerebral Palsy: A Multi-Site Cohort Study. J Clin Med. 2020;9(1):5. doi:10.3390/jcm9010005" /> <meta name="citation_reference" content="Powell M, Hosseini M, Collins J, et al. I Tried a Bunch of Things: The Dangers of Unexpected Overfitting in Classification. Published online February 14, 2020:078816. doi:10.1101/078816" /> <meta name="citation_reference" content="Hosseini M, Powell M, Collins J, et al. I tried a bunch of things: The dangers of unexpected overfitting in classification of brain data. Neurosci Biobehav Rev. 2020;119:456–467. doi:10.1016/j.neubiorev.2020.09.036" /> <meta name="citation_reference" content="Lyu C, Zhang W, Huang H, et al. RTMDet: An Empirical Study of Designing Real-Time Object Detectors. Published online 2022. https://arxiv.org/abs/2212.07784" /> <meta name="citation_reference" content="Lin TY, Maire M, Belongie S, et al. Microsoft COCO: Common Objects in Context. Published online February 20, 2015. doi:10.48550/arXiv.1405.0312" /> <meta name="citation_reference" content="Cao Z, Hidalgo G, Simon T, Wei SE, Sheikh Y. OpenPose: Realtime Multi-Person 2D Pose Estimation Using Part Affinity Fields. IEEE Trans Pattern Anal Mach Intell. 2021;43(1):172–186. doi:10.1109/TPAMI.2019.2929257" /> <meta name="citation_reference" content="Wang W, Xie E, Li X, et al. PVT v2: Improved baselines with Pyramid Vision Transformer. Comput Vis Media. 2022;8(3):415–424. doi:10.1007/s41095-022-0274-8" /> <meta name="citation_reference" content="Mathis A, Mamidanna P, Cury KM, et al. DeepLabCut: markerless pose estimation of user-defined body parts with deep learning. Nat Neurosci. 2018;21(9):1281–1289. doi:10.1038/s41593-018-0209-y" /> <meta name="citation_reference" content="Pereira TD, Tabris N, Matsliah A, et al. SLEAP: A deep learning system for multi-animal pose tracking. Nat Methods. 2022;19(4):486–495." /> <meta name="citation_reference" content="Toshev A, Szegedy C. DeepPose: Human Pose Estimation via Deep Neural Networks. In: 2014 IEEE Conference on Computer Vision and Pattern Recognition.; 2014:1653–1660. doi:10.1109/CVPR.2014.214" /> <meta name="citation_reference" content="Melanie Segado MJKK Claire Chambers, Nidhi Seethapathi, Rachit Saluja, Laura Prosser. Infant Movement Assessment: Update. Published online 2024. https://github.com/quietscientist/Infant_movement_assessment" /> <meta name="citation_reference" content="Segado M. Update: Predicting clinical assessments of infants’ risk of neuromotor disease from 2-dimensional videos. Published online September 2023. doi:10.17605/OSF.IO/SD6FA" /> <meta name="citation_reference" content="Chambers C. Predicting clinical assessments of infants’ risk of neuromotor disease from 2-dimensional videos. Published online November 2018. doi:10.17605/OSF.IO/HV7TM" /> <meta name="citation_reference" content="Ferrari F, Cioni G, Einspieler C, et al. Cramped Synchronized General Movements in Preterm Infants as an Early Marker for Cerebral Palsy. Arch Pediatr Adolesc Med. 2002;156(5):460–467. doi:10.1001/archpedi.156.5.460" /> <meta name="citation_reference" content="Einspieler C, Yang H, Bartl-Pokorny KD, et al. Are sporadic fidgety movements as clinically relevant as is their absence? Early Hum Dev. 2015;91(4):247–252. doi:10.1016/j.earlhumdev.2015.02.003" /> <meta name="citation_reference" content="Feurer M, Eggensperger K, Falkner S, Lindauer M, Hutter F. Auto-Sklearn 2.0: Hands-free AutoML via Meta-Learning. Published online October 4, 2022. doi:10.48550/arXiv.2007.04074" /> <meta name="citation_reference" content="citation_title=Advances in Neural Information Processing Systems;citation_volume=28;citation_year=2015" /> <meta name="citation_reference" content="Pedregosa F, Varoquaux G, Gramfort A, et al. Scikit-learn: Machine Learning in Python. J Mach Learn Res. 2011;12:2825–2830." /> <meta name="twitter:title" content="Assessing infant risk of cerebral palsy with video-based motion tracking" /> <meta name="twitter:site" content="@medrxivpreprint" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:image" content="https://www.medrxiv.org/sites/default/files/images/medrxiv_logo_homepage7-5-small-test-up.png" /> <meta name="twitter:description" content="Cerebral Palsy (CP) is a common (about 1 in 500 children) health condition caused by abnormal brain development that affects the ability to control movement. Early risk assessment happens through the General Movements Assessment (GMA), a test administered by trained clinicians at 3-4 months of age that has high predictive value for CP. With recent improvements in video-based motion tracking, automated risk assessment for CP based on the GMA is being explored. However, studies generally have used small datasets or were limited in terms of methodological rigor. Here we acquired a large dataset (1060 infants) of videos from a clinical population with elevated CP risk. In a preregistered pipeline using a lock-box set that was not used before algorithm submission we find that our machine learning predictions are highly predictive of the clinician-assessed GMA (AUC=0.79). Given its low cost, our video-based approach may be useful for clinical screening applications, particularly in low-resource settings. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This work was funded by NIH-NICHD and the clinical early detection trial data collection was supported in part by the Cerebral Palsy Foundation ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Ethics committee/IRB of The University of Pennsylvania (Penn) gave ethical approval for this work I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All data that is consented for sharing (movement features and trained model) are available online at the OSF pre-registration site (<https://osf.io/sd6fa>) <https://osf.io/sd6fa> <https://doi.org/10.5281/zenodo.14042732>" /> <meta name="og-title" property="og:title" content="Assessing infant risk of cerebral palsy with video-based motion tracking" /> <meta name="og-url" property="og:url" content="https://www.medrxiv.org/content/10.1101/2024.11.06.24316844v1" /> <meta name="og-site-name" property="og:site_name" content="medRxiv" /> <meta name="og-description" property="og:description" content="Cerebral Palsy (CP) is a common (about 1 in 500 children) health condition caused by abnormal brain development that affects the ability to control movement. Early risk assessment happens through the General Movements Assessment (GMA), a test administered by trained clinicians at 3-4 months of age that has high predictive value for CP. With recent improvements in video-based motion tracking, automated risk assessment for CP based on the GMA is being explored. However, studies generally have used small datasets or were limited in terms of methodological rigor. Here we acquired a large dataset (1060 infants) of videos from a clinical population with elevated CP risk. In a preregistered pipeline using a lock-box set that was not used before algorithm submission we find that our machine learning predictions are highly predictive of the clinician-assessed GMA (AUC=0.79). Given its low cost, our video-based approach may be useful for clinical screening applications, particularly in low-resource settings. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This work was funded by NIH-NICHD and the clinical early detection trial data collection was supported in part by the Cerebral Palsy Foundation ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Ethics committee/IRB of The University of Pennsylvania (Penn) gave ethical approval for this work I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All data that is consented for sharing (movement features and trained model) are available online at the OSF pre-registration site (<https://osf.io/sd6fa>) <https://osf.io/sd6fa> <https://doi.org/10.5281/zenodo.14042732>" /> <meta name="og-type" property="og:type" content="article" /> <meta name="og-image" property="og:image" content="https://www.medrxiv.org/sites/default/files/images/medrxiv_logo_homepage7-5-small-test-up.png" /> <meta name="citation_date" content="2024-11-07" /> <link rel="alternate" type="text/plain" title="Full Text (Plain)" href="/content/10.1101/2024.11.06.24316844v1.full.txt" /> <link rel="alternate" type="application/vnd.ms-powerpoint" title="Powerpoint" href="/content/10.1101/2024.11.06.24316844v1.ppt" /> <link rel="alternate" type="application/pdf" title="Full Text (PDF)" href="/content/10.1101/2024.11.06.24316844v1.full.pdf" /> <meta name="description" content="medRxiv - The Preprint Server for Health Sciences" /> <meta name="generator" content="Drupal 7 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class="highwire-article-citation highwire-citation-type-highwire-article node895565" data-node-nid="895565" id="node-895565--21314513859" data-pisa="medrxiv;2024.11.06.24316844v1" data-pisa-master="medrxiv;2024.11.06.24316844" data-apath="/medrxiv/early/2024/11/07/2024.11.06.24316844.atom" data-hw-author-tooltip-instance=""><div class="highwire-cite highwire-cite-highwire-article highwire-citation-medrxiv-article-top clearfix has-author-tooltip" > <h1 class="highwire-cite-title" id="page-title">Assessing infant risk of cerebral palsy with video-based motion tracking</h1> <div class="highwire-cite-authors" ><span class="highwire-citation-authors"><span class="highwire-citation-author first hw-author-orcid-logo-wrapper" data-delta="0"><a href="http://orcid.org/0000-0001-7862-6749" target="_blank" class="hw-author-orcid-logo link-icon-only link-icon"><span class="hw-icon-orcid hw-icon-color-orcid"></span> <span class="title element-invisible">View ORCID Profile</span></a><span class="nlm-given-names">Melanie</span> <span class="nlm-surname">Segado</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Laura</span> <span class="nlm-surname">Prosser</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Andrea F.</span> <span class="nlm-surname">Duncan</span></span>, <span class="highwire-citation-author hw-author-orcid-logo-wrapper" data-delta="3"><a href="http://orcid.org/0000-0002-7964-0304" target="_blank" class="hw-author-orcid-logo link-icon-only link-icon"><span class="hw-icon-orcid hw-icon-color-orcid"></span> <span class="title element-invisible">View ORCID Profile</span></a><span class="nlm-given-names">Michelle J.</span> <span class="nlm-surname">Johnson</span></span>, <span class="highwire-citation-author hw-author-orcid-logo-wrapper" data-delta="4"><a href="http://orcid.org/0000-0001-8408-4499" target="_blank" class="hw-author-orcid-logo link-icon-only link-icon"><span class="hw-icon-orcid hw-icon-color-orcid"></span> <span class="title element-invisible">View ORCID Profile</span></a><span class="nlm-given-names">Konrad P.</span> <span class="nlm-surname">Kording</span></span></span></div> <div class="highwire-cite-metadata" ><span class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">doi:</span> https://doi.org/10.1101/2024.11.06.24316844 </span></div> </div> <div id="hw-article-author-popups-node-895565--21314513859" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Melanie Segado </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>1</span><span class='nlm-institution'>Department of Bioengineering, University of Pennsylvania</span>, Philadelphia, PA, <span class='nlm-country'>United States</span></div><div class='author-affiliation'><span class='nlm-sup'>2</span><span class='nlm-institution'>Department of Neuroscience, University of Pennsylvania</span>, Philadelphia, PA, <span class='nlm-country'>United State</span></div><div class='author-affiliation'><span class='nlm-sup'>5</span><span class='nlm-institution'>Division of Rehabilitation Medicine, The Children’s Hospital of Philadelphia</span>, Philadelphia, PA, <span class='nlm-country'>USA</span></div>PhD</span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Melanie%2BSegado%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Segado%20M&link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AMelanie%2BSegado%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-7862-6749" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Melanie Segado</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">Laura Prosser </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>4</span><span class='nlm-institution'>Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania</span>, Philadelphia, PA, <span class='nlm-country'>USA</span></div><div class='author-affiliation'><span class='nlm-sup'>5</span><span class='nlm-institution'>Division of Rehabilitation Medicine, The Children’s Hospital of Philadelphia</span>, Philadelphia, PA, <span class='nlm-country'>USA</span></div>PT, PhD</span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Laura%2BProsser%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Prosser%20L&link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3ALaura%2BProsser%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-corresp-email-link last"><span>For correspondence: <a href="mailto:prosserl@chop.edu" class="" data-icon-position="" data-hide-link-title="0">prosserl@chop.edu</a></span></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">Andrea F. Duncan </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>4</span><span class='nlm-institution'>Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania</span>, Philadelphia, PA, <span class='nlm-country'>USA</span></div><div class='author-affiliation'><span class='nlm-sup'>6</span><span class='nlm-institution'>Division of Neonatology and Department of Pediatrics, Children’s Hospital of Philadelphia</span></div>MD, MS</span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Andrea%2BF.%2BDuncan%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Duncan%20AF&link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AAndrea%2BF.%2BDuncan%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">Michelle J. Johnson </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>1</span><span class='nlm-institution'>Department of Bioengineering, University of Pennsylvania</span>, Philadelphia, PA, <span class='nlm-country'>United States</span></div><div class='author-affiliation'><span class='nlm-sup'>7</span><span class='nlm-institution'>Department of Physical Medicine and Rehabilitation, University of Pennsylvania</span>, Philadelphia, PA, <span class='nlm-country'>USA</span></div><div class='author-affiliation'><span class='nlm-sup'>8</span><span class='nlm-institution'>Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania</span>, Philadelphia, PA, <span class='nlm-country'>USA</span></div><div class='author-affiliation'><span class='nlm-sup'>9</span><span class='nlm-institution'>Rehabilitation Robotics Lab, Perelman School of Medicine, University of Pennsylvania</span>, Philadelphia, PA, <span class='nlm-country'>USA</span></div>PhD</span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Michelle%2BJ.%2BJohnson%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Johnson%20MJ&link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AMichelle%2BJ.%2BJohnson%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-7964-0304" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Michelle J. Johnson</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">Konrad P. Kording </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>1</span><span class='nlm-institution'>Department of Bioengineering, University of Pennsylvania</span>, Philadelphia, PA, <span class='nlm-country'>United States</span></div><div class='author-affiliation'><span class='nlm-sup'>2</span><span class='nlm-institution'>Department of Neuroscience, University of Pennsylvania</span>, Philadelphia, PA, <span class='nlm-country'>United State</span></div>PhD</span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Konrad%2BP.%2BKording%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kording%20KP&link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AKonrad%2BP.%2BKording%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0001-8408-4499" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Konrad P. Kording</a></li></ul></div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-panel-tabs pane-panels-ajax-tab-tabs" > <div class="pane-content"> <div class="item-list"><ul class="tabs inline panels-ajax-tab"><li class="first"><a href="/content/10.1101/2024.11.06.24316844v1" class="panels-ajax-tab-tab" data-panel-name="biorxiv_tab_art" data-target-id="highwire_article_tabs" data-entity-context="node:895565" data-trigger="" data-url-enabled="1">Abstract</a><a href="/panels_ajax_tab/biorxiv_tab_art/node:895565/1" rel="nofollow" style="display:none" class="js-crawler-link"></a></li><li><a href="/content/10.1101/2024.11.06.24316844v1.full-text" class="panels-ajax-tab-tab" data-panel-name="article_tab_full_text" data-target-id="highwire_article_tabs" data-entity-context="node:895565" data-trigger="full-text" data-url-enabled="1">Full Text</a><a href="/panels_ajax_tab/article_tab_full_text/node:895565/1" rel="nofollow" style="display:none" class="js-crawler-link"></a></li><li><a href="/content/10.1101/2024.11.06.24316844v1.article-info" class="panels-ajax-tab-tab" data-panel-name="biorxiv_tab_info" data-target-id="highwire_article_tabs" data-entity-context="node:895565" data-trigger="article-info" data-url-enabled="1">Info/History</a><a href="/panels_ajax_tab/biorxiv_tab_info/node:895565/1" rel="nofollow" style="display:none" class="js-crawler-link"></a></li><li><a href="/content/10.1101/2024.11.06.24316844v1.article-metrics" class="panels-ajax-tab-tab" data-panel-name="article_tab_metrics" data-target-id="highwire_article_tabs" data-entity-context="node:895565" data-trigger="article-metrics" data-url-enabled="1">Metrics</a><a href="/panels_ajax_tab/article_tab_metrics/node:895565/1" rel="nofollow" style="display:none" class="js-crawler-link"></a></li><li><a href="/content/10.1101/2024.11.06.24316844v1.external-links" class="panels-ajax-tab-tab" data-panel-name="article_tab_data_code" data-target-id="highwire_article_tabs" data-entity-context="node:895565" data-trigger="external-links" data-url-enabled="1">Data/Code</a><a href="/panels_ajax_tab/article_tab_data_code/node:895565/1" rel="nofollow" style="display:none" class="js-crawler-link"></a></li><li class="last"><a href="/content/10.1101/2024.11.06.24316844v1.full.pdf+html" class="panels-ajax-tab-tab" data-panel-name="biorxiv_tab_pdf" data-target-id="highwire_article_tabs" data-entity-context="node:895565" data-trigger="full.pdf+html" data-url-enabled="1"><i class="icon-file-alt"></i> Preview PDF</a><a href="/panels_ajax_tab/biorxiv_tab_pdf/node:895565/1" rel="nofollow" style="display:none" class="js-crawler-link"></a></li></ul></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-panel-tabs-container" > <div class="pane-content"> <div data-panels-ajax-tab-preloaded="biorxiv_tab_art" id="panels-ajax-tab-container-highwire_article_tabs" class="panels-ajax-tab-container"><div class="panels-ajax-tab-loading" style ="display:none"><img class="loading" src="https://www.medrxiv.org/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif" alt="Loading" title="Loading" /></div><div class="panels-ajax-tab-wrap-biorxiv_tab_art"><div class="panel-display panel-1col clearfix" > <div class="panel-panel panel-col"> <div><div class="panel-pane pane-highwire-markup" > <div class="pane-content"> <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" data-highwire-cite-ref-tooltip-instance="highwire_reflinks_tooltip" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article abstract-view "><span class="highwire-journal-article-marker-start"></span><div class="section abstract" id="abstract-1"><h2 class="">Abstract</h2><p id="p-2">Cerebral Palsy (CP) is a common (about 1 in 500 children) health condition caused by abnormal brain development that affects the ability to control movement. Early risk assessment happens through the General Movements Assessment (GMA), a test administered by trained clinicians at 3-4 months of age that has high predictive value for CP. With recent improvements in video-based motion tracking, automated risk assessment for CP based on the GMA is being explored. However, studies generally have used small datasets or were limited in terms of methodological rigor. Here we acquired a large dataset (1060 infants) of videos from a clinical population with elevated CP risk. In a preregistered pipeline using a lock-box set that was not used before algorithm submission we find that our machine learning predictions are highly predictive of the clinician-assessed GMA (AUC=0.79). Given its low cost, our video-based approach may be useful for clinical screening applications, particularly in low-resource settings.</p></div><h3>Competing Interest Statement</h3><p id="p-3">The authors have declared no competing interest.</p><h3>Funding Statement</h3><p id="p-4">This work was funded by NIH-NICHD and the clinical early detection trial data collection was supported in part by the Cerebral Palsy Foundation</p><h3>Author Declarations</h3><p id="p-5">I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.</p><p id="p-6">Yes</p><p id="p-7">The details of the IRB/oversight body that provided approval or exemption for the research described are given below:</p><p id="p-8">Ethics committee/IRB of The University of Pennsylvania (Penn) gave ethical approval for this work</p><p id="p-9">I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.</p><p id="p-10">Yes</p><p id="p-11">I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).</p><p id="p-12">Yes</p><p id="p-13">I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.</p><p id="p-14">Yes</p><div class="section data-availability" id="sec-12"><h2 class="">Data Availability</h2><p id="p-45">All data that is consented for sharing (movement features and trained model) are available online at the OSF pre-registration site (<a href="https://osf.io/sd6fa">https://osf.io/sd6fa</a>)</p><p id="p-46"> <a href="https://osf.io/sd6fa">https://osf.io/sd6fa</a> </p><p id="p-47"> <a href="https://doi.org/10.5281/zenodo.14042732">https://doi.org/10.5281/zenodo.14042732</a> 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class="highwire-cite-metadata-journal highwire-cite-metadata">medRxiv </span><span class="highwire-cite-metadata-pages highwire-cite-metadata">2024.11.06.24316844; </span><span class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="doi_label">doi:</span> https://doi.org/10.1101/2024.11.06.24316844 </span></div> </div> </div> </div> <div class="highwire-citation-formats"> <h2>Citation Manager Formats</h2> <div class="highwire-citation-formats-links"> <span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.spage&rft.epage&rft.atitle=Assessing%20infant%20risk%20of%20cerebral%20palsy%20with%20video-based%20motion%20tracking&rft.volume&rft.issue&rft.date=2024-01-01%2000%3A00%3A00&rft.stitle&rft.jtitle=medRxiv&rft.au=Segado%2C+Melanie&rft.au=Prosser%2C+Laura&rft.au=Duncan%2C+Andrea+F.&rft.au=Johnson%2C+Michelle+J.&rft.au=Kording%2C+Konrad+P."></span><ul class="hw-citation-links inline button button-alt button-grid clearfix"><li 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