Type I Interferon Signaling Pathways

<!DOCTYPE html> <html lang="en" dir="ltr" prefix="content: http://purl.org/rss/1.0/modules/content/ dc: http://purl.org/dc/terms/ foaf: http://xmlns.com/foaf/0.1/ rdfs: http://www.w3.org/2000/01/rdf-schema# sioc: http://rdfs.org/sioc/ns# sioct: http://rdfs.org/sioc/types# skos: http://www.w3.org/2004/02/skos/core# xsd: http://www.w3.org/2001/XMLSchema#"> <head> <meta charset="UTF-8"><script type="text/javascript">(window.NREUM||(NREUM={})).init={privacy:{cookies_enabled:true},ajax:{deny_list:[]},session_replay:{sampling_rate:10.0,mask_text_selector:"",block_selector:"",mask_input_options:{date:true,text_area:true,week:true,select:true,color:true,range:true,textarea:true,url:true,number:true,search:true,month:true,datetime_local:true,tel:true,text:true,time:true,email:true},enabled:true,error_sampling_rate:100.0},session_trace:{sampling_rate:10.0,mode:"PROBABILISTIC",enabled:true,error_sampling_rate:100.0}};(window.NREUM||(NREUM={})).loader_config={xpid:"UA8FUVBADwsIV1VaAgIH",licenseKey:"76fb58fb05",applicationID:"788348530"};;/*! For license information please see nr-loader-full-1.274.0.min.js.LICENSE.txt */ (()=>{var e,t,r={8122:(e,t,r)=>{"use strict";r.d(t,{a:()=>i});var n=r(944);function i(e,t){try{if(!e||"object"!=typeof e)return(0,n.R)(3);if(!t||"object"!=typeof t)return(0,n.R)(4);const r=Object.create(Object.getPrototypeOf(t),Object.getOwnPropertyDescriptors(t)),o=0===Object.keys(r).length?e:r;for(let a in o)if(void 0!==e[a])try{if(null===e[a]){r[a]=null;continue}Array.isArray(e[a])&&Array.isArray(t[a])?r[a]=Array.from(new Set([...e[a],...t[a]])):"object"==typeof e[a]&&"object"==typeof t[a]?r[a]=i(e[a],t[a]):r[a]=e[a]}catch(e){(0,n.R)(1,e)}return r}catch(e){(0,n.R)(2,e)}}},2555:(e,t,r)=>{"use strict";r.d(t,{Vp:()=>c,fn:()=>s,x1:()=>d});var n=r(384),i=r(8122);const o={beacon:n.NT.beacon,errorBeacon:n.NT.errorBeacon,licenseKey:void 0,applicationID:void 0,sa:void 0,queueTime:void 0,applicationTime:void 0,ttGuid:void 0,user:void 0,account:void 0,product:void 0,extra:void 0,jsAttributes:{},userAttributes:void 0,atts:void 0,transactionName:void 0,tNamePlain:void 0},a={};function s(e){try{const t=c(e);return!!t.licenseKey&&!!t.errorBeacon&&!!t.applicationID}catch(e){return!1}}function c(e){if(!e)throw new Error("All info objects require an agent identifier!");if(!a[e])throw new Error("Info for ".concat(e," was never set"));return a[e]}function d(e,t){if(!e)throw new Error("All info objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.info=a[e])}},9417:(e,t,r)=>{"use strict";r.d(t,{D0:()=>h,gD:()=>p,xN:()=>g});var n=r(993);const i=e=>{if(!e||"string"!=typeof e)return!1;try{document.createDocumentFragment().querySelector(e)}catch{return!1}return!0};var o=r(2614),a=r(944),s=r(384),c=r(8122);const d="[data-nr-mask]",u=()=>{const e={mask_selector:"*",block_selector:"[data-nr-block]",mask_input_options:{color:!1,date:!1,"datetime-local":!1,email:!1,month:!1,number:!1,range:!1,search:!1,tel:!1,text:!1,time:!1,url:!1,week:!1,textarea:!1,select:!1,password:!0}};return{ajax:{deny_list:void 0,block_internal:!0,enabled:!0,harvestTimeSeconds:10,autoStart:!0},distributed_tracing:{enabled:void 0,exclude_newrelic_header:void 0,cors_use_newrelic_header:void 0,cors_use_tracecontext_headers:void 0,allowed_origins:void 0},feature_flags:[],generic_events:{enabled:!0,harvestTimeSeconds:30,autoStart:!0},harvest:{tooManyRequestsDelay:60},jserrors:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},logging:{enabled:!0,harvestTimeSeconds:10,autoStart:!0,level:n.p_.INFO},metrics:{enabled:!0,autoStart:!0},obfuscate:void 0,page_action:{enabled:!0},page_view_event:{enabled:!0,autoStart:!0},page_view_timing:{enabled:!0,harvestTimeSeconds:30,autoStart:!0},performance:{capture_marks:!1,capture_measures:!1},privacy:{cookies_enabled:!0},proxy:{assets:void 0,beacon:void 0},session:{expiresMs:o.wk,inactiveMs:o.BB},session_replay:{autoStart:!0,enabled:!1,harvestTimeSeconds:60,preload:!1,sampling_rate:10,error_sampling_rate:100,collect_fonts:!1,inline_images:!1,fix_stylesheets:!0,mask_all_inputs:!0,get mask_text_selector(){return e.mask_selector},set mask_text_selector(t){i(t)?e.mask_selector="".concat(t,",").concat(d):""===t||null===t?e.mask_selector=d:(0,a.R)(5,t)},get block_class(){return"nr-block"},get ignore_class(){return"nr-ignore"},get mask_text_class(){return"nr-mask"},get block_selector(){return e.block_selector},set block_selector(t){i(t)?e.block_selector+=",".concat(t):""!==t&&(0,a.R)(6,t)},get mask_input_options(){return e.mask_input_options},set mask_input_options(t){t&&"object"==typeof t?e.mask_input_options={...t,password:!0}:(0,a.R)(7,t)}},session_trace:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},soft_navigations:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},spa:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},ssl:void 0,user_actions:{enabled:!0}}},l={},f="All configuration objects require an agent identifier!";function h(e){if(!e)throw new Error(f);if(!l[e])throw new Error("Configuration for ".concat(e," was never set"));return l[e]}function g(e,t){if(!e)throw new Error(f);l[e]=(0,c.a)(t,u());const r=(0,s.nY)(e);r&&(r.init=l[e])}function p(e,t){if(!e)throw new Error(f);var r=h(e);if(r){for(var n=t.split("."),i=0;i<n.length-1;i++)if("object"!=typeof(r=r[n[i]]))return;r=r[n[n.length-1]]}return r}},5603:(e,t,r)=>{"use strict";r.d(t,{a:()=>c,o:()=>s});var n=r(384),i=r(8122);const o={accountID:void 0,trustKey:void 0,agentID:void 0,licenseKey:void 0,applicationID:void 0,xpid:void 0},a={};function s(e){if(!e)throw new Error("All loader-config objects require an agent identifier!");if(!a[e])throw new Error("LoaderConfig for ".concat(e," was never set"));return a[e]}function c(e,t){if(!e)throw new Error("All loader-config objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.loader_config=a[e])}},3371:(e,t,r)=>{"use strict";r.d(t,{V:()=>f,f:()=>l});var n=r(8122),i=r(384),o=r(6154),a=r(9324);let s=0;const c={buildEnv:a.F3,distMethod:a.Xs,version:a.xv,originTime:o.WN},d={customTransaction:void 0,disabled:!1,isolatedBacklog:!1,loaderType:void 0,maxBytes:3e4,onerror:void 0,ptid:void 0,releaseIds:{},appMetadata:{},session:void 0,denyList:void 0,timeKeeper:void 0,obfuscator:void 0},u={};function l(e){if(!e)throw new Error("All runtime objects require an agent identifier!");if(!u[e])throw new Error("Runtime for ".concat(e," was never set"));return u[e]}function f(e,t){if(!e)throw new Error("All runtime objects require an agent identifier!");u[e]={...(0,n.a)(t,d),...c},Object.hasOwnProperty.call(u[e],"harvestCount")||Object.defineProperty(u[e],"harvestCount",{get:()=>++s});const r=(0,i.nY)(e);r&&(r.runtime=u[e])}},9324:(e,t,r)=>{"use strict";r.d(t,{F3:()=>i,Xs:()=>o,Yq:()=>a,xv:()=>n});const n="1.274.0",i="PROD",o="CDN",a="^2.0.0-alpha.17"},6154:(e,t,r)=>{"use strict";r.d(t,{OF:()=>d,RI:()=>i,WN:()=>f,bv:()=>o,gm:()=>a,lR:()=>l,m:()=>c,mw:()=>s,sb:()=>u});var n=r(1863);const i="undefined"!=typeof window&&!!window.document,o="undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self.navigator instanceof WorkerNavigator||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis.navigator instanceof WorkerNavigator),a=i?window:"undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis),s=Boolean("hidden"===a?.document?.visibilityState),c=""+a?.location,d=/iPad|iPhone|iPod/.test(a.navigator?.userAgent),u=d&&"undefined"==typeof SharedWorker,l=(()=>{const e=a.navigator?.userAgent?.match(/Firefox[/\s](\d+\.\d+)/);return Array.isArray(e)&&e.length>=2?+e[1]:0})(),f=Date.now()-(0,n.t)()},7295:(e,t,r)=>{"use strict";r.d(t,{Xv:()=>a,gX:()=>i,iW:()=>o});var n=[];function i(e){if(!e||o(e))return!1;if(0===n.length)return!0;for(var t=0;t<n.length;t++){var r=n[t];if("*"===r.hostname)return!1;if(s(r.hostname,e.hostname)&&c(r.pathname,e.pathname))return!1}return!0}function o(e){return void 0===e.hostname}function a(e){if(n=[],e&&e.length)for(var t=0;t<e.length;t++){let r=e[t];if(!r)continue;0===r.indexOf("http://")?r=r.substring(7):0===r.indexOf("https://")&&(r=r.substring(8));const i=r.indexOf("/");let o,a;i>0?(o=r.substring(0,i),a=r.substring(i)):(o=r,a="");let[s]=o.split(":");n.push({hostname:s,pathname:a})}}function s(e,t){return!(e.length>t.length)&&t.indexOf(e)===t.length-e.length}function c(e,t){return 0===e.indexOf("/")&&(e=e.substring(1)),0===t.indexOf("/")&&(t=t.substring(1)),""===e||e===t}},1687:(e,t,r)=>{"use strict";r.d(t,{Ak:()=>c,Ze:()=>l,x3:()=>d});var n=r(7836),i=r(3606),o=r(860),a=r(2646);const s={};function c(e,t){const r={staged:!1,priority:o.P3[t]||0};u(e),s[e].get(t)||s[e].set(t,r)}function d(e,t){e&&s[e]&&(s[e].get(t)&&s[e].delete(t),h(e,t,!1),s[e].size&&f(e))}function u(e){if(!e)throw new Error("agentIdentifier required");s[e]||(s[e]=new Map)}function l(e="",t="feature",r=!1){if(u(e),!e||!s[e].get(t)||r)return h(e,t);s[e].get(t).staged=!0,f(e)}function f(e){const t=Array.from(s[e]);t.every((([e,t])=>t.staged))&&(t.sort(((e,t)=>e[1].priority-t[1].priority)),t.forEach((([t])=>{s[e].delete(t),h(e,t)})))}function h(e,t,r=!0){const o=e?n.ee.get(e):n.ee,s=i.i.handlers;if(!o.aborted&&o.backlog&&s){if(r){const e=o.backlog[t],r=s[t];if(r){for(let t=0;e&&t<e.length;++t)g(e[t],r);Object.entries(r).forEach((([e,t])=>{Object.values(t||{}).forEach((t=>{t[0]?.on&&t[0]?.context()instanceof a.y&&t[0].on(e,t[1])}))}))}}o.isolatedBacklog||delete s[t],o.backlog[t]=null,o.emit("drain-"+t,[])}}function g(e,t){var r=e[1];Object.values(t[r]||{}).forEach((t=>{var r=e[0];if(t[0]===r){var n=t[1],i=e[3],o=e[2];n.apply(i,o)}}))}},7836:(e,t,r)=>{"use strict";r.d(t,{P:()=>c,ee:()=>d});var n=r(384),i=r(8990),o=r(3371),a=r(2646),s=r(5607);const c="nr@context:".concat(s.W),d=function e(t,r){var n={},s={},u={},l=!1;try{l=16===r.length&&(0,o.f)(r).isolatedBacklog}catch(e){}var f={on:g,addEventListener:g,removeEventListener:function(e,t){var r=n[e];if(!r)return;for(var i=0;i<r.length;i++)r[i]===t&&r.splice(i,1)},emit:function(e,r,n,i,o){!1!==o&&(o=!0);if(d.aborted&&!i)return;t&&o&&t.emit(e,r,n);for(var a=h(n),c=p(e),u=c.length,l=0;l<u;l++)c[l].apply(a,r);var g=v()[s[e]];g&&g.push([f,e,r,a]);return a},get:m,listeners:p,context:h,buffer:function(e,t){const r=v();if(t=t||"feature",f.aborted)return;Object.entries(e||{}).forEach((([e,n])=>{s[n]=t,t in r||(r[t]=[])}))},abort:function(){f._aborted=!0,Object.keys(f.backlog).forEach((e=>{delete f.backlog[e]}))},isBuffering:function(e){return!!v()[s[e]]},debugId:r,backlog:l?{}:t&&"object"==typeof t.backlog?t.backlog:{},isolatedBacklog:l};return Object.defineProperty(f,"aborted",{get:()=>{let e=f._aborted||!1;return e||(t&&(e=t.aborted),e)}}),f;function h(e){return e&&e instanceof a.y?e:e?(0,i.I)(e,c,(()=>new a.y(c))):new a.y(c)}function g(e,t){n[e]=p(e).concat(t)}function p(e){return n[e]||[]}function m(t){return u[t]=u[t]||e(f,t)}function v(){return f.backlog}}(void 0,"globalEE"),u=(0,n.Zm)();u.ee||(u.ee=d)},2646:(e,t,r)=>{"use strict";r.d(t,{y:()=>n});class n{constructor(e){this.contextId=e}}},9908:(e,t,r)=>{"use strict";r.d(t,{d:()=>n,p:()=>i});var n=r(7836).ee.get("handle");function i(e,t,r,i,o){o?(o.buffer([e],i),o.emit(e,t,r)):(n.buffer([e],i),n.emit(e,t,r))}},3606:(e,t,r)=>{"use strict";r.d(t,{i:()=>o});var n=r(9908);o.on=a;var i=o.handlers={};function o(e,t,r,o){a(o||n.d,i,e,t,r)}function a(e,t,r,i,o){o||(o="feature"),e||(e=n.d);var a=t[o]=t[o]||{};(a[r]=a[r]||[]).push([e,i])}},3878:(e,t,r)=>{"use strict";function n(e,t){return{capture:e,passive:!1,signal:t}}function i(e,t,r=!1,i){window.addEventListener(e,t,n(r,i))}function o(e,t,r=!1,i){document.addEventListener(e,t,n(r,i))}r.d(t,{DD:()=>o,jT:()=>n,sp:()=>i})},5607:(e,t,r)=>{"use strict";r.d(t,{W:()=>n});const n=(0,r(9566).bz)()},9566:(e,t,r)=>{"use strict";r.d(t,{LA:()=>s,ZF:()=>c,bz:()=>a,el:()=>d});var n=r(6154);const i="xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx";function o(e,t){return e?15&e[t]:16*Math.random()|0}function a(){const e=n.gm?.crypto||n.gm?.msCrypto;let t,r=0;return e&&e.getRandomValues&&(t=e.getRandomValues(new Uint8Array(30))),i.split("").map((e=>"x"===e?o(t,r++).toString(16):"y"===e?(3&o()|8).toString(16):e)).join("")}function s(e){const t=n.gm?.crypto||n.gm?.msCrypto;let r,i=0;t&&t.getRandomValues&&(r=t.getRandomValues(new Uint8Array(e)));const a=[];for(var s=0;s<e;s++)a.push(o(r,i++).toString(16));return a.join("")}function c(){return s(16)}function d(){return s(32)}},2614:(e,t,r)=>{"use strict";r.d(t,{BB:()=>a,H3:()=>n,g:()=>d,iL:()=>c,tS:()=>s,uh:()=>i,wk:()=>o});const n="NRBA",i="SESSION",o=144e5,a=18e5,s={STARTED:"session-started",PAUSE:"session-pause",RESET:"session-reset",RESUME:"session-resume",UPDATE:"session-update"},c={SAME_TAB:"same-tab",CROSS_TAB:"cross-tab"},d={OFF:0,FULL:1,ERROR:2}},1863:(e,t,r)=>{"use strict";function n(){return Math.floor(performance.now())}r.d(t,{t:()=>n})},7485:(e,t,r)=>{"use strict";r.d(t,{D:()=>i});var n=r(6154);function i(e){if(0===(e||"").indexOf("data:"))return{protocol:"data"};try{const t=new URL(e,location.href),r={port:t.port,hostname:t.hostname,pathname:t.pathname,search:t.search,protocol:t.protocol.slice(0,t.protocol.indexOf(":")),sameOrigin:t.protocol===n.gm?.location?.protocol&&t.host===n.gm?.location?.host};return r.port&&""!==r.port||("http:"===t.protocol&&(r.port="80"),"https:"===t.protocol&&(r.port="443")),r.pathname&&""!==r.pathname?r.pathname.startsWith("/")||(r.pathname="/".concat(r.pathname)):r.pathname="/",r}catch(e){return{}}}},944:(e,t,r)=>{"use strict";function n(e,t){"function"==typeof console.debug&&console.debug("New Relic Warning: https://github.com/newrelic/newrelic-browser-agent/blob/main/docs/warning-codes.md#".concat(e),t)}r.d(t,{R:()=>n})},5284:(e,t,r)=>{"use strict";r.d(t,{t:()=>c,B:()=>s});var n=r(7836),i=r(6154);const o="newrelic";const a=new Set,s={};function c(e,t){const r=n.ee.get(t);s[t]??={},e&&"object"==typeof e&&(a.has(t)||(r.emit("rumresp",[e]),s[t]=e,a.add(t),function(e={}){try{i.gm.dispatchEvent(new CustomEvent(o,{detail:e}))}catch(e){}}({loaded:!0})))}},8990:(e,t,r)=>{"use strict";r.d(t,{I:()=>i});var n=Object.prototype.hasOwnProperty;function i(e,t,r){if(n.call(e,t))return e[t];var i=r();if(Object.defineProperty&&Object.keys)try{return Object.defineProperty(e,t,{value:i,writable:!0,enumerable:!1}),i}catch(e){}return e[t]=i,i}},6389:(e,t,r)=>{"use strict";function n(e,t=500,r={}){const n=r?.leading||!1;let i;return(...r)=>{n&&void 0===i&&(e.apply(this,r),i=setTimeout((()=>{i=clearTimeout(i)}),t)),n||(clearTimeout(i),i=setTimeout((()=>{e.apply(this,r)}),t))}}function i(e){let t=!1;return(...r)=>{t||(t=!0,e.apply(this,r))}}r.d(t,{J:()=>i,s:()=>n})},3304:(e,t,r)=>{"use strict";r.d(t,{A:()=>o});var n=r(7836);const i=()=>{const e=new WeakSet;return(t,r)=>{if("object"==typeof r&&null!==r){if(e.has(r))return;e.add(r)}return r}};function o(e){try{return JSON.stringify(e,i())??""}catch(e){try{n.ee.emit("internal-error",[e])}catch(e){}return""}}},5289:(e,t,r)=>{"use strict";r.d(t,{GG:()=>o,sB:()=>a});var n=r(3878);function i(){return"undefined"==typeof document||"complete"===document.readyState}function o(e,t){if(i())return e();(0,n.sp)("load",e,t)}function a(e){if(i())return e();(0,n.DD)("DOMContentLoaded",e)}},384:(e,t,r)=>{"use strict";r.d(t,{NT:()=>o,US:()=>u,Zm:()=>a,bQ:()=>c,dV:()=>s,nY:()=>d,pV:()=>l});var n=r(6154),i=r(1863);const o={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net"};function a(){return n.gm.NREUM||(n.gm.NREUM={}),void 0===n.gm.newrelic&&(n.gm.newrelic=n.gm.NREUM),n.gm.NREUM}function s(){let e=a();return e.o||(e.o={ST:n.gm.setTimeout,SI:n.gm.setImmediate,CT:n.gm.clearTimeout,XHR:n.gm.XMLHttpRequest,REQ:n.gm.Request,EV:n.gm.Event,PR:n.gm.Promise,MO:n.gm.MutationObserver,FETCH:n.gm.fetch,WS:n.gm.WebSocket}),e}function c(e,t){let r=a();r.initializedAgents??={},t.initializedAt={ms:(0,i.t)(),date:new Date},r.initializedAgents[e]=t}function d(e){let t=a();return t.initializedAgents?.[e]}function u(e,t){a()[e]=t}function l(){return function(){let e=a();const t=e.info||{};e.info={beacon:o.beacon,errorBeacon:o.errorBeacon,...t}}(),function(){let e=a();const t=e.init||{};e.init={...t}}(),s(),function(){let e=a();const t=e.loader_config||{};e.loader_config={...t}}(),a()}},2843:(e,t,r)=>{"use strict";r.d(t,{u:()=>i});var n=r(3878);function i(e,t=!1,r,i){(0,n.DD)("visibilitychange",(function(){if(t)return void("hidden"===document.visibilityState&&e());e(document.visibilityState)}),r,i)}},8139:(e,t,r)=>{"use strict";r.d(t,{u:()=>f});var n=r(7836),i=r(3434),o=r(8990),a=r(6154);const s={},c=a.gm.XMLHttpRequest,d="addEventListener",u="removeEventListener",l="nr@wrapped:".concat(n.P);function f(e){var t=function(e){return(e||n.ee).get("events")}(e);if(s[t.debugId]++)return t;s[t.debugId]=1;var r=(0,i.YM)(t,!0);function f(e){r.inPlace(e,[d,u],"-",g)}function g(e,t){return e[1]}return"getPrototypeOf"in Object&&(a.RI&&h(document,f),h(a.gm,f),h(c.prototype,f)),t.on(d+"-start",(function(e,t){var n=e[1];if(null!==n&&("function"==typeof n||"object"==typeof n)){var i=(0,o.I)(n,l,(function(){var e={object:function(){if("function"!=typeof n.handleEvent)return;return n.handleEvent.apply(n,arguments)},function:n}[typeof n];return e?r(e,"fn-",null,e.name||"anonymous"):n}));this.wrapped=e[1]=i}})),t.on(u+"-start",(function(e){e[1]=this.wrapped||e[1]})),t}function h(e,t,...r){let n=e;for(;"object"==typeof n&&!Object.prototype.hasOwnProperty.call(n,d);)n=Object.getPrototypeOf(n);n&&t(n,...r)}},3434:(e,t,r)=>{"use strict";r.d(t,{YM:()=>c});var n=r(7836),i=r(5607);const o="nr@original:".concat(i.W);var a=Object.prototype.hasOwnProperty,s=!1;function c(e,t){return e||(e=n.ee),r.inPlace=function(e,t,n,i,o){n||(n="");const a="-"===n.charAt(0);for(let s=0;s<t.length;s++){const c=t[s],d=e[c];u(d)||(e[c]=r(d,a?c+n:n,i,c,o))}},r.flag=o,r;function r(t,r,n,s,c){return u(t)?t:(r||(r=""),nrWrapper[o]=t,function(e,t,r){if(Object.defineProperty&&Object.keys)try{return Object.keys(e).forEach((function(r){Object.defineProperty(t,r,{get:function(){return e[r]},set:function(t){return e[r]=t,t}})})),t}catch(e){d([e],r)}for(var n in e)a.call(e,n)&&(t[n]=e[n])}(t,nrWrapper,e),nrWrapper);function nrWrapper(){var o,a,u,l;try{a=this,o=[...arguments],u="function"==typeof n?n(o,a):n||{}}catch(t){d([t,"",[o,a,s],u],e)}i(r+"start",[o,a,s],u,c);try{return l=t.apply(a,o)}catch(e){throw i(r+"err",[o,a,e],u,c),e}finally{i(r+"end",[o,a,l],u,c)}}}function i(r,n,i,o){if(!s||t){var a=s;s=!0;try{e.emit(r,n,i,t,o)}catch(t){d([t,r,n,i],e)}s=a}}}function d(e,t){t||(t=n.ee);try{t.emit("internal-error",e)}catch(e){}}function u(e){return!(e&&"function"==typeof e&&e.apply&&!e[o])}},9300:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.ajax},3333:(e,t,r)=>{"use strict";r.d(t,{TZ:()=>n,Zp:()=>i,mq:()=>s,nf:()=>a,qN:()=>o});const n=r(860).K7.genericEvents,i=["auxclick","click","copy","keydown","paste","scrollend"],o=["focus","blur"],a=4,s=1e3},6774:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.jserrors},993:(e,t,r)=>{"use strict";r.d(t,{ET:()=>o,TZ:()=>a,p_:()=>i});var n=r(860);const i={ERROR:"ERROR",WARN:"WARN",INFO:"INFO",DEBUG:"DEBUG",TRACE:"TRACE"},o="log",a=n.K7.logging},3785:(e,t,r)=>{"use strict";r.d(t,{R:()=>c,b:()=>d});var n=r(9908),i=r(1863),o=r(860),a=r(3969),s=r(993);function c(e,t,r={},c=s.p_.INFO){(0,n.p)(a.xV,["API/logging/".concat(c.toLowerCase(),"/called")],void 0,o.K7.metrics,e),(0,n.p)(s.ET,[(0,i.t)(),t,r,c],void 0,o.K7.logging,e)}function d(e){return"string"==typeof e&&Object.values(s.p_).some((t=>t===e.toUpperCase().trim()))}},3969:(e,t,r)=>{"use strict";r.d(t,{TZ:()=>n,XG:()=>s,rs:()=>i,xV:()=>a,z_:()=>o});const n=r(860).K7.metrics,i="sm",o="cm",a="storeSupportabilityMetrics",s="storeEventMetrics"},6630:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewEvent},782:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewTiming},6344:(e,t,r)=>{"use strict";r.d(t,{BB:()=>u,G4:()=>o,Qb:()=>l,TZ:()=>i,Ug:()=>a,_s:()=>s,bc:()=>d,yP:()=>c});var n=r(2614);const i=r(860).K7.sessionReplay,o={RECORD:"recordReplay",PAUSE:"pauseReplay",REPLAY_RUNNING:"replayRunning",ERROR_DURING_REPLAY:"errorDuringReplay"},a=.12,s={DomContentLoaded:0,Load:1,FullSnapshot:2,IncrementalSnapshot:3,Meta:4,Custom:5},c={[n.g.ERROR]:15e3,[n.g.FULL]:3e5,[n.g.OFF]:0},d={RESET:{message:"Session was reset",sm:"Reset"},IMPORT:{message:"Recorder failed to import",sm:"Import"},TOO_MANY:{message:"429: Too Many Requests",sm:"Too-Many"},TOO_BIG:{message:"Payload was too large",sm:"Too-Big"},CROSS_TAB:{message:"Session Entity was set to OFF on another tab",sm:"Cross-Tab"},ENTITLEMENTS:{message:"Session Replay is not allowed and will not be started",sm:"Entitlement"}},u=5e3,l={API:"api"}},5270:(e,t,r)=>{"use strict";r.d(t,{Aw:()=>c,CT:()=>d,SR:()=>s});var n=r(384),i=r(9417),o=r(7767),a=r(6154);function s(e){return!!(0,n.dV)().o.MO&&(0,o.V)(e)&&!0===(0,i.gD)(e,"session_trace.enabled")}function c(e){return!0===(0,i.gD)(e,"session_replay.preload")&&s(e)}function d(e,t){const r=t.correctAbsoluteTimestamp(e);return{originalTimestamp:e,correctedTimestamp:r,timestampDiff:e-r,originTime:a.WN,correctedOriginTime:t.correctedOriginTime,originTimeDiff:Math.floor(a.WN-t.correctedOriginTime)}}},3738:(e,t,r)=>{"use strict";r.d(t,{He:()=>i,Kp:()=>s,Lc:()=>d,Rz:()=>u,TZ:()=>n,bD:()=>o,d3:()=>a,jx:()=>l,uP:()=>c});const n=r(860).K7.sessionTrace,i="bstResource",o="resource",a="-start",s="-end",c="fn"+a,d="fn"+s,u="pushState",l=1e3},4234:(e,t,r)=>{"use strict";r.d(t,{W:()=>o});var n=r(7836),i=r(1687);class o{constructor(e,t){this.agentIdentifier=e,this.ee=n.ee.get(e),this.featureName=t,this.blocked=!1}deregisterDrain(){(0,i.x3)(this.agentIdentifier,this.featureName)}}},7767:(e,t,r)=>{"use strict";r.d(t,{V:()=>o});var n=r(9417),i=r(6154);const o=e=>i.RI&&!0===(0,n.gD)(e,"privacy.cookies_enabled")},425:(e,t,r)=>{"use strict";r.d(t,{j:()=>P});var n=r(860),i=r(2555),o=r(3371),a=r(9908),s=r(7836),c=r(1687),d=r(5289),u=r(6154),l=r(944),f=r(3969),h=r(384),g=r(6344);const p=["setErrorHandler","finished","addToTrace","addRelease","addPageAction","setCurrentRouteName","setPageViewName","setCustomAttribute","interaction","noticeError","setUserId","setApplicationVersion","start",g.G4.RECORD,g.G4.PAUSE,"log","wrapLogger"],m=["setErrorHandler","finished","addToTrace","addRelease"];var v=r(1863),b=r(2614),y=r(993),R=r(3785),x=r(2646),w=r(3434);function T(e,t,r,n){if("object"!=typeof t||!t||"string"!=typeof r||!r||"function"!=typeof t[r])return(0,l.R)(29);const i=function(e){return(e||s.ee).get("logger")}(e),o=(0,w.YM)(i),a=new x.y(s.P);return a.level=n.level,a.customAttributes=n.customAttributes,o.inPlace(t,[r],"wrap-logger-",a),i}function A(){const e=(0,h.pV)();p.forEach((t=>{e[t]=(...r)=>function(t,...r){let n=[];return Object.values(e.initializedAgents).forEach((e=>{e&&e.api?e.exposed&&e.api[t]&&n.push(e.api[t](...r)):(0,l.R)(38,t)})),n.length>1?n:n[0]}(t,...r)}))}const E={};var S=r(9417),_=r(5603),O=r(5284);const N=e=>{const t=e.startsWith("http");e+="/",r.p=t?e:"https://"+e};let I=!1;function P(e,t={},p,x){let{init:w,info:P,loader_config:j,runtime:C={},exposed:k=!0}=t;C.loaderType=p;const H=(0,h.pV)();P||(w=H.init,P=H.info,j=H.loader_config),(0,S.xN)(e.agentIdentifier,w||{}),(0,_.a)(e.agentIdentifier,j||{}),P.jsAttributes??={},u.bv&&(P.jsAttributes.isWorker=!0),(0,i.x1)(e.agentIdentifier,P);const D=(0,S.D0)(e.agentIdentifier),L=[P.beacon,P.errorBeacon];I||(D.proxy.assets&&(N(D.proxy.assets),L.push(D.proxy.assets)),D.proxy.beacon&&L.push(D.proxy.beacon),A(),(0,h.US)("activatedFeatures",O.B),e.runSoftNavOverSpa&&=!0===D.soft_navigations.enabled&&D.feature_flags.includes("soft_nav")),C.denyList=[...D.ajax.deny_list||[],...D.ajax.block_internal?L:[]],C.ptid=e.agentIdentifier,(0,o.V)(e.agentIdentifier,C),e.ee=s.ee.get(e.agentIdentifier),void 0===e.api&&(e.api=function(e,t,h=!1){t||(0,c.Ak)(e,"api");const p={};var x=s.ee.get(e),w=x.get("tracer");E[e]=b.g.OFF,x.on(g.G4.REPLAY_RUNNING,(t=>{E[e]=t}));var A="api-",S=A+"ixn-";function _(t,r,n,o){const a=(0,i.Vp)(e);return null===r?delete a.jsAttributes[t]:(0,i.x1)(e,{...a,jsAttributes:{...a.jsAttributes,[t]:r}}),I(A,n,!0,o||null===r?"session":void 0)(t,r)}function O(){}p.log=function(e,{customAttributes:t={},level:r=y.p_.INFO}={}){(0,a.p)(f.xV,["API/log/called"],void 0,n.K7.metrics,x),(0,R.R)(x,e,t,r)},p.wrapLogger=(e,t,{customAttributes:r={},level:i=y.p_.INFO}={})=>{(0,a.p)(f.xV,["API/wrapLogger/called"],void 0,n.K7.metrics,x),T(x,e,t,{customAttributes:r,level:i})},m.forEach((e=>{p[e]=I(A,e,!0,"api")})),p.addPageAction=I(A,"addPageAction",!0,n.K7.genericEvents),p.setPageViewName=function(t,r){if("string"==typeof t)return"/"!==t.charAt(0)&&(t="/"+t),(0,o.f)(e).customTransaction=(r||"http://custom.transaction")+t,I(A,"setPageViewName",!0)()},p.setCustomAttribute=function(e,t,r=!1){if("string"==typeof e){if(["string","number","boolean"].includes(typeof t)||null===t)return _(e,t,"setCustomAttribute",r);(0,l.R)(40,typeof t)}else(0,l.R)(39,typeof e)},p.setUserId=function(e){if("string"==typeof e||null===e)return _("enduser.id",e,"setUserId",!0);(0,l.R)(41,typeof e)},p.setApplicationVersion=function(e){if("string"==typeof e||null===e)return _("application.version",e,"setApplicationVersion",!1);(0,l.R)(42,typeof e)},p.start=()=>{try{(0,a.p)(f.xV,["API/start/called"],void 0,n.K7.metrics,x),x.emit("manual-start-all")}catch(e){(0,l.R)(23,e)}},p[g.G4.RECORD]=function(){(0,a.p)(f.xV,["API/recordReplay/called"],void 0,n.K7.metrics,x),(0,a.p)(g.G4.RECORD,[],void 0,n.K7.sessionReplay,x)},p[g.G4.PAUSE]=function(){(0,a.p)(f.xV,["API/pauseReplay/called"],void 0,n.K7.metrics,x),(0,a.p)(g.G4.PAUSE,[],void 0,n.K7.sessionReplay,x)},p.interaction=function(e){return(new O).get("object"==typeof e?e:{})};const N=O.prototype={createTracer:function(e,t){var r={},i=this,o="function"==typeof t;return(0,a.p)(f.xV,["API/createTracer/called"],void 0,n.K7.metrics,x),h||(0,a.p)(S+"tracer",[(0,v.t)(),e,r],i,n.K7.spa,x),function(){if(w.emit((o?"":"no-")+"fn-start",[(0,v.t)(),i,o],r),o)try{return t.apply(this,arguments)}catch(e){const t="string"==typeof e?new Error(e):e;throw w.emit("fn-err",[arguments,this,t],r),t}finally{w.emit("fn-end",[(0,v.t)()],r)}}}};function I(e,t,r,i){return function(){return(0,a.p)(f.xV,["API/"+t+"/called"],void 0,n.K7.metrics,x),i&&(0,a.p)(e+t,[(0,v.t)(),...arguments],r?null:this,i,x),r?void 0:this}}function P(){r.e(891).then(r.bind(r,8778)).then((({setAPI:t})=>{t(e),(0,c.Ze)(e,"api")})).catch((e=>{(0,l.R)(27,e),x.abort()}))}return["actionText","setName","setAttribute","save","ignore","onEnd","getContext","end","get"].forEach((e=>{N[e]=I(S,e,void 0,h?n.K7.softNav:n.K7.spa)})),p.setCurrentRouteName=h?I(S,"routeName",void 0,n.K7.softNav):I(A,"routeName",!0,n.K7.spa),p.noticeError=function(t,r){"string"==typeof t&&(t=new Error(t)),(0,a.p)(f.xV,["API/noticeError/called"],void 0,n.K7.metrics,x),(0,a.p)("err",[t,(0,v.t)(),!1,r,!!E[e]],void 0,n.K7.jserrors,x)},u.RI?(0,d.GG)((()=>P()),!0):P(),p}(e.agentIdentifier,x,e.runSoftNavOverSpa)),void 0===e.exposed&&(e.exposed=k),I=!0}},8374:(e,t,r)=>{r.nc=(()=>{try{return document?.currentScript?.nonce}catch(e){}return""})()},860:(e,t,r)=>{"use strict";r.d(t,{$J:()=>o,K7:()=>n,P3:()=>i});const n={ajax:"ajax",genericEvents:"generic_events",jserrors:"jserrors",logging:"logging",metrics:"metrics",pageAction:"page_action",pageViewEvent:"page_view_event",pageViewTiming:"page_view_timing",sessionReplay:"session_replay",sessionTrace:"session_trace",softNav:"soft_navigations",spa:"spa"},i={[n.pageViewEvent]:1,[n.pageViewTiming]:2,[n.metrics]:3,[n.jserrors]:4,[n.spa]:5,[n.ajax]:6,[n.sessionTrace]:7,[n.softNav]:8,[n.sessionReplay]:9,[n.logging]:10,[n.genericEvents]:11},o={[n.pageViewTiming]:"events",[n.ajax]:"events",[n.spa]:"events",[n.softNav]:"events",[n.metrics]:"jserrors",[n.jserrors]:"jserrors",[n.sessionTrace]:"browser/blobs",[n.sessionReplay]:"browser/blobs",[n.logging]:"browser/logs",[n.genericEvents]:"ins"}}},n={};function i(e){var t=n[e];if(void 0!==t)return t.exports;var o=n[e]={exports:{}};return r[e](o,o.exports,i),o.exports}i.m=r,i.d=(e,t)=>{for(var r in t)i.o(t,r)&&!i.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},i.f={},i.e=e=>Promise.all(Object.keys(i.f).reduce(((t,r)=>(i.f[r](e,t),t)),[])),i.u=e=>({95:"nr-full-compressor",222:"nr-full-recorder",891:"nr-full"}[e]+"-1.274.0.min.js"),i.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),e={},t="NRBA-1.274.0.PROD:",i.l=(r,n,o,a)=>{if(e[r])e[r].push(n);else{var s,c;if(void 0!==o)for(var d=document.getElementsByTagName("script"),u=0;u<d.length;u++){var l=d[u];if(l.getAttribute("src")==r||l.getAttribute("data-webpack")==t+o){s=l;break}}if(!s){c=!0;var f={891:"sha512-Sx2xJQrHp2m/Ngn/ZcfBCUwNr2Xy/C5urYtWpfm3bWpil4spXOQGTtNwIfF5HvPGioGASn9QTyE4Z+zC7r7wcg==",222:"sha512-hMte3OWgwwYeisSiD7WCIx/6tT16zLaPjag9uF4tIZp7ybOvrJKbeyzhe4fz1tDbkdcdOMm8dvgPPLBatSAGeA==",95:"sha512-MPaT9dkHv16XzwEUVZPyqpN1do/Er1XFAZoIAPYWylmv+iGIThqN+GwQq27pUyAX7sNXVJQVZezH96p53Ks3Pg=="};(s=document.createElement("script")).charset="utf-8",s.timeout=120,i.nc&&s.setAttribute("nonce",i.nc),s.setAttribute("data-webpack",t+o),s.src=r,0!==s.src.indexOf(window.location.origin+"/")&&(s.crossOrigin="anonymous"),f[a]&&(s.integrity=f[a])}e[r]=[n];var h=(t,n)=>{s.onerror=s.onload=null,clearTimeout(g);var i=e[r];if(delete e[r],s.parentNode&&s.parentNode.removeChild(s),i&&i.forEach((e=>e(n))),t)return t(n)},g=setTimeout(h.bind(null,void 0,{type:"timeout",target:s}),12e4);s.onerror=h.bind(null,s.onerror),s.onload=h.bind(null,s.onload),c&&document.head.appendChild(s)}},i.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},i.p="https://js-agent.newrelic.com/",(()=>{var e={959:0,85:0};i.f.j=(t,r)=>{var n=i.o(e,t)?e[t]:void 0;if(0!==n)if(n)r.push(n[2]);else{var o=new Promise(((r,i)=>n=e[t]=[r,i]));r.push(n[2]=o);var a=i.p+i.u(t),s=new Error;i.l(a,(r=>{if(i.o(e,t)&&(0!==(n=e[t])&&(e[t]=void 0),n)){var o=r&&("load"===r.type?"missing":r.type),a=r&&r.target&&r.target.src;s.message="Loading chunk "+t+" failed.\n("+o+": "+a+")",s.name="ChunkLoadError",s.type=o,s.request=a,n[1](s)}}),"chunk-"+t,t)}};var t=(t,r)=>{var n,o,[a,s,c]=r,d=0;if(a.some((t=>0!==e[t]))){for(n in s)i.o(s,n)&&(i.m[n]=s[n]);if(c)c(i)}for(t&&t(r);d<a.length;d++)o=a[d],i.o(e,o)&&e[o]&&e[o][0](),e[o]=0},r=self["webpackChunk:NRBA-1.274.0.PROD"]=self["webpackChunk:NRBA-1.274.0.PROD"]||[];r.forEach(t.bind(null,0)),r.push=t.bind(null,r.push.bind(r))})(),(()=>{"use strict";i(8374);var e=i(944),t=i(6344),r=i(9566);class n{agentIdentifier;constructor(e=(0,r.LA)(16)){this.agentIdentifier=e}#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}addPageAction(e,t){return this.#e("addPageAction",e,t)}setPageViewName(e,t){return this.#e("setPageViewName",e,t)}setCustomAttribute(e,t,r){return this.#e("setCustomAttribute",e,t,r)}noticeError(e,t){return this.#e("noticeError",e,t)}setUserId(e){return this.#e("setUserId",e)}setApplicationVersion(e){return this.#e("setApplicationVersion",e)}setErrorHandler(e){return this.#e("setErrorHandler",e)}addRelease(e,t){return this.#e("addRelease",e,t)}log(e,t){return this.#e("log",e,t)}}class o extends n{#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}start(){return this.#e("start")}finished(e){return this.#e("finished",e)}recordReplay(){return this.#e(t.G4.RECORD)}pauseReplay(){return this.#e(t.G4.PAUSE)}addToTrace(e){return this.#e("addToTrace",e)}setCurrentRouteName(e){return this.#e("setCurrentRouteName",e)}interaction(){return this.#e("interaction")}wrapLogger(e,t,r){return this.#e("wrapLogger",e,t,r)}}var a=i(860),s=i(9417);const c=Object.values(a.K7);function d(e){const t={};return c.forEach((r=>{t[r]=function(e,t){return!0===(0,s.gD)(t,"".concat(e,".enabled"))}(r,e)})),t}var u=i(425);var l=i(1687),f=i(4234),h=i(5289),g=i(6154),p=i(5270),m=i(7767),v=i(6389);class b extends f.W{constructor(e,t,r=!0){super(e.agentIdentifier,t),this.auto=r,this.abortHandler=void 0,this.featAggregate=void 0,this.onAggregateImported=void 0,!1===e.init[this.featureName].autoStart&&(this.auto=!1),this.auto?(0,l.Ak)(e.agentIdentifier,t):this.ee.on("manual-start-all",(0,v.J)((()=>{(0,l.Ak)(e.agentIdentifier,this.featureName),this.auto=!0,this.importAggregator(e)})))}importAggregator(t,r={}){if(this.featAggregate||!this.auto)return;let n;this.onAggregateImported=new Promise((e=>{n=e}));const o=async()=>{let o;try{if((0,m.V)(this.agentIdentifier)){const{setupAgentSession:e}=await i.e(891).then(i.bind(i,6526));o=e(t)}}catch(t){(0,e.R)(20,t),this.ee.emit("internal-error",[t]),this.featureName===a.K7.sessionReplay&&this.abortHandler?.()}try{if(t.sharedAggregator)await t.sharedAggregator;else{t.sharedAggregator=i.e(891).then(i.bind(i,9337));const{EventAggregator:e}=await t.sharedAggregator;t.sharedAggregator=new e}if(!this.#t(this.featureName,o))return(0,l.Ze)(this.agentIdentifier,this.featureName),void n(!1);const{lazyFeatureLoader:e}=await i.e(891).then(i.bind(i,6103)),{Aggregate:a}=await e(this.featureName,"aggregate");this.featAggregate=new a(t,r),n(!0)}catch(t){(0,e.R)(34,t),this.abortHandler?.(),(0,l.Ze)(this.agentIdentifier,this.featureName,!0),n(!1),this.ee&&this.ee.abort()}};g.RI?(0,h.GG)((()=>o()),!0):o()}#t(e,t){switch(e){case a.K7.sessionReplay:return(0,p.SR)(this.agentIdentifier)&&!!t;case a.K7.sessionTrace:return!!t;default:return!0}}}var y=i(6630);class R extends b{static featureName=y.T;constructor(e,t=!0){super(e,y.T,t),this.importAggregator(e)}}var x=i(384);var w=i(9908),T=i(2843),A=i(3878),E=i(782),S=i(1863);class _ extends b{static featureName=E.T;constructor(e,t=!0){super(e,E.T,t),g.RI&&((0,T.u)((()=>(0,w.p)("docHidden",[(0,S.t)()],void 0,E.T,this.ee)),!0),(0,A.sp)("pagehide",(()=>(0,w.p)("winPagehide",[(0,S.t)()],void 0,E.T,this.ee))),this.importAggregator(e))}}var O=i(3969);class N extends b{static featureName=O.TZ;constructor(e,t=!0){super(e,O.TZ,t),this.importAggregator(e)}}var I=i(6774),P=i(3304);class j{constructor(e,t,r,n,i){this.name="UncaughtError",this.message="string"==typeof e?e:(0,P.A)(e),this.sourceURL=t,this.line=r,this.column=n,this.__newrelic=i}}function C(e){return D(e)?e:new j(void 0!==e?.message?e.message:e,e?.filename||e?.sourceURL,e?.lineno||e?.line,e?.colno||e?.col,e?.__newrelic)}function k(e){const t="Unhandled Promise Rejection";if(!e?.reason)return;if(D(e.reason))try{return e.reason.message=t+": "+e.reason.message,C(e.reason)}catch(t){return C(e.reason)}const r=C(e.reason);return r.message=t+": "+r?.message,r}function H(e){if(e.error instanceof SyntaxError&&!/:\d+$/.test(e.error.stack?.trim())){const t=new j(e.message,e.filename,e.lineno,e.colno,e.error.__newrelic);return t.name=SyntaxError.name,t}return D(e.error)?e.error:C(e)}function D(e){return e instanceof Error&&!!e.stack}class L extends b{static featureName=I.T;#r=!1;constructor(e,r=!0){super(e,I.T,r);try{this.removeOnAbort=new AbortController}catch(e){}this.ee.on("internal-error",(e=>{this.abortHandler&&(0,w.p)("ierr",[C(e),(0,S.t)(),!0,{},this.#r],void 0,this.featureName,this.ee)})),this.ee.on(t.G4.REPLAY_RUNNING,(e=>{this.#r=e})),g.gm.addEventListener("unhandledrejection",(e=>{this.abortHandler&&(0,w.p)("err",[k(e),(0,S.t)(),!1,{unhandledPromiseRejection:1},this.#r],void 0,this.featureName,this.ee)}),(0,A.jT)(!1,this.removeOnAbort?.signal)),g.gm.addEventListener("error",(e=>{this.abortHandler&&(0,w.p)("err",[H(e),(0,S.t)(),!1,{},this.#r],void 0,this.featureName,this.ee)}),(0,A.jT)(!1,this.removeOnAbort?.signal)),this.abortHandler=this.#n,this.importAggregator(e)}#n(){this.removeOnAbort?.abort(),this.abortHandler=void 0}}var K=i(8990);let M=1;const U="nr@id";function V(e){const t=typeof e;return!e||"object"!==t&&"function"!==t?-1:e===g.gm?0:(0,K.I)(e,U,(function(){return M++}))}function G(e){if("string"==typeof e&&e.length)return e.length;if("object"==typeof e){if("undefined"!=typeof ArrayBuffer&&e instanceof ArrayBuffer&&e.byteLength)return e.byteLength;if("undefined"!=typeof Blob&&e instanceof Blob&&e.size)return e.size;if(!("undefined"!=typeof FormData&&e instanceof FormData))try{return(0,P.A)(e).length}catch(e){return}}}var F=i(8139),B=i(7836),W=i(3434);const z={},q=["open","send"];function Z(t){var r=t||B.ee;const n=function(e){return(e||B.ee).get("xhr")}(r);if(z[n.debugId]++)return n;z[n.debugId]=1,(0,F.u)(r);var i=(0,W.YM)(n),o=g.gm.XMLHttpRequest,a=g.gm.MutationObserver,s=g.gm.Promise,c=g.gm.setInterval,d="readystatechange",u=["onload","onerror","onabort","onloadstart","onloadend","onprogress","ontimeout"],l=[],f=g.gm.XMLHttpRequest=function(t){const r=new o(t),a=n.context(r);try{n.emit("new-xhr",[r],a),r.addEventListener(d,(s=a,function(){var e=this;e.readyState>3&&!s.resolved&&(s.resolved=!0,n.emit("xhr-resolved",[],e)),i.inPlace(e,u,"fn-",y)}),(0,A.jT)(!1))}catch(t){(0,e.R)(15,t);try{n.emit("internal-error",[t])}catch(e){}}var s;return r};function h(e,t){i.inPlace(t,["onreadystatechange"],"fn-",y)}if(function(e,t){for(var r in e)t[r]=e[r]}(o,f),f.prototype=o.prototype,i.inPlace(f.prototype,q,"-xhr-",y),n.on("send-xhr-start",(function(e,t){h(e,t),function(e){l.push(e),a&&(p?p.then(b):c?c(b):(m=-m,v.data=m))}(t)})),n.on("open-xhr-start",h),a){var p=s&&s.resolve();if(!c&&!s){var m=1,v=document.createTextNode(m);new a(b).observe(v,{characterData:!0})}}else r.on("fn-end",(function(e){e[0]&&e[0].type===d||b()}));function b(){for(var e=0;e<l.length;e++)h(0,l[e]);l.length&&(l=[])}function y(e,t){return t}return n}var Y="fetch-",X=Y+"body-",Q=["arrayBuffer","blob","json","text","formData"],J=g.gm.Request,ee=g.gm.Response,te="prototype";const re={};function ne(e){const t=function(e){return(e||B.ee).get("fetch")}(e);if(!(J&&ee&&g.gm.fetch))return t;if(re[t.debugId]++)return t;function r(e,r,n){var i=e[r];"function"==typeof i&&(e[r]=function(){var e,r=[...arguments],o={};t.emit(n+"before-start",[r],o),o[B.P]&&o[B.P].dt&&(e=o[B.P].dt);var a=i.apply(this,r);return t.emit(n+"start",[r,e],a),a.then((function(e){return t.emit(n+"end",[null,e],a),e}),(function(e){throw t.emit(n+"end",[e],a),e}))})}return re[t.debugId]=1,Q.forEach((e=>{r(J[te],e,X),r(ee[te],e,X)})),r(g.gm,"fetch",Y),t.on(Y+"end",(function(e,r){var n=this;if(r){var i=r.headers.get("content-length");null!==i&&(n.rxSize=i),t.emit(Y+"done",[null,r],n)}else t.emit(Y+"done",[e],n)})),t}var ie=i(7485),oe=i(5603);class ae{constructor(e){this.agentIdentifier=e}generateTracePayload(e){if(!this.shouldGenerateTrace(e))return null;var t=(0,oe.o)(this.agentIdentifier);if(!t)return null;var n=(t.accountID||"").toString()||null,i=(t.agentID||"").toString()||null,o=(t.trustKey||"").toString()||null;if(!n||!i)return null;var a=(0,r.ZF)(),s=(0,r.el)(),c=Date.now(),d={spanId:a,traceId:s,timestamp:c};return(e.sameOrigin||this.isAllowedOrigin(e)&&this.useTraceContextHeadersForCors())&&(d.traceContextParentHeader=this.generateTraceContextParentHeader(a,s),d.traceContextStateHeader=this.generateTraceContextStateHeader(a,c,n,i,o)),(e.sameOrigin&&!this.excludeNewrelicHeader()||!e.sameOrigin&&this.isAllowedOrigin(e)&&this.useNewrelicHeaderForCors())&&(d.newrelicHeader=this.generateTraceHeader(a,s,c,n,i,o)),d}generateTraceContextParentHeader(e,t){return"00-"+t+"-"+e+"-01"}generateTraceContextStateHeader(e,t,r,n,i){return i+"@nr=0-1-"+r+"-"+n+"-"+e+"----"+t}generateTraceHeader(e,t,r,n,i,o){if(!("function"==typeof g.gm?.btoa))return null;var a={v:[0,1],d:{ty:"Browser",ac:n,ap:i,id:e,tr:t,ti:r}};return o&&n!==o&&(a.d.tk=o),btoa((0,P.A)(a))}shouldGenerateTrace(e){return this.isDtEnabled()&&this.isAllowedOrigin(e)}isAllowedOrigin(e){var t=!1,r={};if((0,s.gD)(this.agentIdentifier,"distributed_tracing")&&(r=(0,s.D0)(this.agentIdentifier).distributed_tracing),e.sameOrigin)t=!0;else if(r.allowed_origins instanceof Array)for(var n=0;n<r.allowed_origins.length;n++){var i=(0,ie.D)(r.allowed_origins[n]);if(e.hostname===i.hostname&&e.protocol===i.protocol&&e.port===i.port){t=!0;break}}return t}isDtEnabled(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.enabled}excludeNewrelicHeader(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.exclude_newrelic_header}useNewrelicHeaderForCors(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!1!==e.cors_use_newrelic_header}useTraceContextHeadersForCors(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.cors_use_tracecontext_headers}}var se=i(9300),ce=i(7295),de=["load","error","abort","timeout"],ue=de.length,le=(0,x.dV)().o.REQ,fe=(0,x.dV)().o.XHR;class he extends b{static featureName=se.T;constructor(e,t=!0){super(e,se.T,t),this.dt=new ae(e.agentIdentifier),this.handler=(e,t,r,n)=>(0,w.p)(e,t,r,n,this.ee);try{const e={xmlhttprequest:"xhr",fetch:"fetch",beacon:"beacon"};g.gm?.performance?.getEntriesByType("resource").forEach((t=>{if(t.initiatorType in e&&0!==t.responseStatus){const r={status:t.responseStatus},n={rxSize:t.transferSize,duration:Math.floor(t.duration),cbTime:0};ge(r,t.name),this.handler("xhr",[r,n,t.startTime,t.responseEnd,e[t.initiatorType]],void 0,a.K7.ajax)}}))}catch(e){}ne(this.ee),Z(this.ee),function(e,t,r,n){function i(e){var t=this;t.totalCbs=0,t.called=0,t.cbTime=0,t.end=x,t.ended=!1,t.xhrGuids={},t.lastSize=null,t.loadCaptureCalled=!1,t.params=this.params||{},t.metrics=this.metrics||{},e.addEventListener("load",(function(r){T(t,e)}),(0,A.jT)(!1)),g.lR||e.addEventListener("progress",(function(e){t.lastSize=e.loaded}),(0,A.jT)(!1))}function o(e){this.params={method:e[0]},ge(this,e[1]),this.metrics={}}function s(t,r){e.loader_config.xpid&&this.sameOrigin&&r.setRequestHeader("X-NewRelic-ID",e.loader_config.xpid);var i=n.generateTracePayload(this.parsedOrigin);if(i){var o=!1;i.newrelicHeader&&(r.setRequestHeader("newrelic",i.newrelicHeader),o=!0),i.traceContextParentHeader&&(r.setRequestHeader("traceparent",i.traceContextParentHeader),i.traceContextStateHeader&&r.setRequestHeader("tracestate",i.traceContextStateHeader),o=!0),o&&(this.dt=i)}}function c(e,r){var n=this.metrics,i=e[0],o=this;if(n&&i){var a=G(i);a&&(n.txSize=a)}this.startTime=(0,S.t)(),this.body=i,this.listener=function(e){try{"abort"!==e.type||o.loadCaptureCalled||(o.params.aborted=!0),("load"!==e.type||o.called===o.totalCbs&&(o.onloadCalled||"function"!=typeof r.onload)&&"function"==typeof o.end)&&o.end(r)}catch(e){try{t.emit("internal-error",[e])}catch(e){}}};for(var s=0;s<ue;s++)r.addEventListener(de[s],this.listener,(0,A.jT)(!1))}function d(e,t,r){this.cbTime+=e,t?this.onloadCalled=!0:this.called+=1,this.called!==this.totalCbs||!this.onloadCalled&&"function"==typeof r.onload||"function"!=typeof this.end||this.end(r)}function u(e,t){var r=""+V(e)+!!t;this.xhrGuids&&!this.xhrGuids[r]&&(this.xhrGuids[r]=!0,this.totalCbs+=1)}function l(e,t){var r=""+V(e)+!!t;this.xhrGuids&&this.xhrGuids[r]&&(delete this.xhrGuids[r],this.totalCbs-=1)}function f(){this.endTime=(0,S.t)()}function h(e,r){r instanceof fe&&"load"===e[0]&&t.emit("xhr-load-added",[e[1],e[2]],r)}function p(e,r){r instanceof fe&&"load"===e[0]&&t.emit("xhr-load-removed",[e[1],e[2]],r)}function m(e,t,r){t instanceof fe&&("onload"===r&&(this.onload=!0),("load"===(e[0]&&e[0].type)||this.onload)&&(this.xhrCbStart=(0,S.t)()))}function v(e,r){this.xhrCbStart&&t.emit("xhr-cb-time",[(0,S.t)()-this.xhrCbStart,this.onload,r],r)}function b(e){var t,r=e[1]||{};if("string"==typeof e[0]?0===(t=e[0]).length&&g.RI&&(t=""+g.gm.location.href):e[0]&&e[0].url?t=e[0].url:g.gm?.URL&&e[0]&&e[0]instanceof URL?t=e[0].href:"function"==typeof e[0].toString&&(t=e[0].toString()),"string"==typeof t&&0!==t.length){t&&(this.parsedOrigin=(0,ie.D)(t),this.sameOrigin=this.parsedOrigin.sameOrigin);var i=n.generateTracePayload(this.parsedOrigin);if(i&&(i.newrelicHeader||i.traceContextParentHeader))if(e[0]&&e[0].headers)s(e[0].headers,i)&&(this.dt=i);else{var o={};for(var a in r)o[a]=r[a];o.headers=new Headers(r.headers||{}),s(o.headers,i)&&(this.dt=i),e.length>1?e[1]=o:e.push(o)}}function s(e,t){var r=!1;return t.newrelicHeader&&(e.set("newrelic",t.newrelicHeader),r=!0),t.traceContextParentHeader&&(e.set("traceparent",t.traceContextParentHeader),t.traceContextStateHeader&&e.set("tracestate",t.traceContextStateHeader),r=!0),r}}function y(e,t){this.params={},this.metrics={},this.startTime=(0,S.t)(),this.dt=t,e.length>=1&&(this.target=e[0]),e.length>=2&&(this.opts=e[1]);var r,n=this.opts||{},i=this.target;"string"==typeof i?r=i:"object"==typeof i&&i instanceof le?r=i.url:g.gm?.URL&&"object"==typeof i&&i instanceof URL&&(r=i.href),ge(this,r);var o=(""+(i&&i instanceof le&&i.method||n.method||"GET")).toUpperCase();this.params.method=o,this.body=n.body,this.txSize=G(n.body)||0}function R(e,t){if(this.endTime=(0,S.t)(),this.params||(this.params={}),(0,ce.iW)(this.params))return;let n;this.params.status=t?t.status:0,"string"==typeof this.rxSize&&this.rxSize.length>0&&(n=+this.rxSize);const i={txSize:this.txSize,rxSize:n,duration:(0,S.t)()-this.startTime};r("xhr",[this.params,i,this.startTime,this.endTime,"fetch"],this,a.K7.ajax)}function x(e){const t=this.params,n=this.metrics;if(!this.ended){this.ended=!0;for(let t=0;t<ue;t++)e.removeEventListener(de[t],this.listener,!1);t.aborted||(0,ce.iW)(t)||(n.duration=(0,S.t)()-this.startTime,this.loadCazptureCalled||4!==e.readyState?null==t.status&&(t.status=0):T(this,e),n.cbTime=this.cbTime,r("xhr",[t,n,this.startTime,this.endTime,"xhr"],this,a.K7.ajax))}}function T(e,r){e.params.status=r.status;var n=function(e,t){var r=e.responseType;return"json"===r&&null!==t?t:"arraybuffer"===r||"blob"===r||"json"===r?G(e.response):"text"===r||""===r||void 0===r?G(e.responseText):void 0}(r,e.lastSize);if(n&&(e.metrics.rxSize=n),e.sameOrigin){var i=r.getResponseHeader("X-NewRelic-App-Data");i&&((0,w.p)(O.rs,["Ajax/CrossApplicationTracing/Header/Seen"],void 0,a.K7.metrics,t),e.params.cat=i.split(", ").pop())}e.loadCaptureCalled=!0}t.on("new-xhr",i),t.on("open-xhr-start",o),t.on("open-xhr-end",s),t.on("send-xhr-start",c),t.on("xhr-cb-time",d),t.on("xhr-load-added",u),t.on("xhr-load-removed",l),t.on("xhr-resolved",f),t.on("addEventListener-end",h),t.on("removeEventListener-end",p),t.on("fn-end",v),t.on("fetch-before-start",b),t.on("fetch-start",y),t.on("fn-start",m),t.on("fetch-done",R)}(e,this.ee,this.handler,this.dt),this.importAggregator(e)}}function ge(e,t){var r=(0,ie.D)(t),n=e.params||e;n.hostname=r.hostname,n.port=r.port,n.protocol=r.protocol,n.host=r.hostname+":"+r.port,n.pathname=r.pathname,e.parsedOrigin=r,e.sameOrigin=r.sameOrigin}const pe={},me=["pushState","replaceState"];function ve(e){const t=function(e){return(e||B.ee).get("history")}(e);return!g.RI||pe[t.debugId]++||(pe[t.debugId]=1,(0,W.YM)(t).inPlace(window.history,me,"-")),t}var be=i(3738);const{He:ye,bD:Re,d3:xe,Kp:we,TZ:Te,Lc:Ae,uP:Ee,Rz:Se}=be;class _e extends b{static featureName=Te;constructor(e,t=!0){super(e,Te,t);if(!(0,m.V)(this.agentIdentifier))return void this.deregisterDrain();const r=this.ee;let n;ve(r),this.eventsEE=(0,F.u)(r),this.eventsEE.on(Ee,(function(e,t){this.bstStart=(0,S.t)()})),this.eventsEE.on(Ae,(function(e,t){(0,w.p)("bst",[e[0],t,this.bstStart,(0,S.t)()],void 0,a.K7.sessionTrace,r)})),r.on(Se+xe,(function(e){this.time=(0,S.t)(),this.startPath=location.pathname+location.hash})),r.on(Se+we,(function(e){(0,w.p)("bstHist",[location.pathname+location.hash,this.startPath,this.time],void 0,a.K7.sessionTrace,r)}));try{n=new PerformanceObserver((e=>{const t=e.getEntries();(0,w.p)(ye,[t],void 0,a.K7.sessionTrace,r)})),n.observe({type:Re,buffered:!0})}catch(e){}this.importAggregator(e,{resourceObserver:n})}}var Oe=i(2614);class Ne extends b{static featureName=t.TZ;#i;#o;constructor(e,r=!0){let n;super(e,t.TZ,r),this.replayRunning=!1,this.#o=e;try{n=JSON.parse(localStorage.getItem("".concat(Oe.H3,"_").concat(Oe.uh)))}catch(e){}(0,p.SR)(e.agentIdentifier)&&this.ee.on(t.G4.RECORD,(()=>this.#a())),this.#s(n)?(this.#i=n?.sessionReplayMode,this.#c()):this.importAggregator(e),this.ee.on("err",(e=>{this.replayRunning&&(this.errorNoticed=!0,(0,w.p)(t.G4.ERROR_DURING_REPLAY,[e],void 0,this.featureName,this.ee))})),this.ee.on(t.G4.REPLAY_RUNNING,(e=>{this.replayRunning=e}))}#s(e){return e&&(e.sessionReplayMode===Oe.g.FULL||e.sessionReplayMode===Oe.g.ERROR)||(0,p.Aw)(this.agentIdentifier)}#d=!1;async#c(e){if(!this.#d){this.#d=!0;try{const{Recorder:t}=await Promise.all([i.e(891),i.e(222)]).then(i.bind(i,8589));this.recorder??=new t({mode:this.#i,agentIdentifier:this.agentIdentifier,trigger:e,ee:this.ee}),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording}catch(e){}this.importAggregator(this.#o,{recorder:this.recorder,errorNoticed:this.errorNoticed})}}#a(){this.featAggregate?this.featAggregate.mode!==Oe.g.FULL&&this.featAggregate.initializeRecording(Oe.g.FULL,!0):(this.#i=Oe.g.FULL,this.#c(t.Qb.API),this.recorder&&this.recorder.parent.mode!==Oe.g.FULL&&(this.recorder.parent.mode=Oe.g.FULL,this.recorder.stopRecording(),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording))}}var Ie=i(3333);class Pe extends b{static featureName=Ie.TZ;constructor(e,t=!0){super(e,Ie.TZ,t);const r=[e.init.page_action.enabled,e.init.performance.capture_marks,e.init.performance.capture_measures,e.init.user_actions.enabled];g.RI&&e.init.user_actions.enabled&&(Ie.Zp.forEach((e=>(0,A.sp)(e,(e=>(0,w.p)("ua",[e],void 0,this.featureName,this.ee)),!0))),Ie.qN.forEach((e=>(0,A.sp)(e,(e=>(0,w.p)("ua",[e],void 0,this.featureName,this.ee)))))),r.some((e=>e))?this.importAggregator(e):this.deregisterDrain()}}var je=i(993),Ce=i(3785);class ke extends b{static featureName=je.TZ;constructor(e,t=!0){super(e,je.TZ,t);const r=this.ee;this.ee.on("wrap-logger-end",(function([e]){const{level:t,customAttributes:n}=this;(0,Ce.R)(r,e,n,t)})),this.importAggregator(e)}}new class extends o{constructor(t,r){super(r),g.gm?(this.features={},(0,x.bQ)(this.agentIdentifier,this),this.desiredFeatures=new Set(t.features||[]),this.desiredFeatures.add(R),this.runSoftNavOverSpa=[...this.desiredFeatures].some((e=>e.featureName===a.K7.softNav)),(0,u.j)(this,t,t.loaderType||"agent"),this.run()):(0,e.R)(21)}get config(){return{info:this.info,init:this.init,loader_config:this.loader_config,runtime:this.runtime}}run(){try{const t=d(this.agentIdentifier),r=[...this.desiredFeatures];r.sort(((e,t)=>a.P3[e.featureName]-a.P3[t.featureName])),r.forEach((r=>{if(!t[r.featureName]&&r.featureName!==a.K7.pageViewEvent)return;if(this.runSoftNavOverSpa&&r.featureName===a.K7.spa)return;if(!this.runSoftNavOverSpa&&r.featureName===a.K7.softNav)return;const n=function(e){switch(e){case a.K7.ajax:return[a.K7.jserrors];case a.K7.sessionTrace:return[a.K7.ajax,a.K7.pageViewEvent];case a.K7.sessionReplay:return[a.K7.sessionTrace];case a.K7.pageViewTiming:return[a.K7.pageViewEvent];default:return[]}}(r.featureName).filter((e=>!(e in this.features)));n.length>0&&(0,e.R)(36,{targetFeature:r.featureName,missingDependencies:n}),this.features[r.featureName]=new r(this)}))}catch(t){(0,e.R)(22,t);for(const e in this.features)this.features[e].abortHandler?.();const r=(0,x.Zm)();delete r.initializedAgents[this.agentIdentifier]?.api,delete r.initializedAgents[this.agentIdentifier]?.features,delete this.sharedAggregator;return r.ee.get(this.agentIdentifier).abort(),!1}}}({features:[R,_,_e,Ne,he,N,L,Pe,ke],loaderType:"pro"})})()})();</script> <link rel="profile" href="http://www.w3.org/1999/xhtml/vocab" /> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <meta name="keywords" content="" /> <link rel="canonical" href="https://www.rndsystems.com/pathways/type-i-interferon-signaling-pathways" /> <meta http-equiv="content-language" content="en-us" /> <link href="https://www.rndsystems.com/pathways/type-i-interferon-signaling-pathways" rel="alternate" hreflang="x-default" /> <link href="https://www.rndsystems.com/pathways/type-i-interferon-signaling-pathways" rel="alternate" hreflang="en" /> <link href="https://www.rndsystems.com/cn/pathways/type-i-interferon-signaling-pathways" rel="alternate" hreflang="zh-cn" /> <meta name="baidu-site-verification" content="NoHNFT2tiZ" /> <title>Type I Interferon Signaling Pathways</title> <meta name="description" content="View our interactive Type I Interferon Signaling Pathway and see the signaling pathways that are activated by members of either the type II or type III interferon families." /> <script id="json-ld" type="application/ld+json">[{"@context":"http://schema.org","@type":"WebPage","breadcrumb":{"@context":"http://schema.org","@type":"BreadcrumbList","itemListElement":[{"@context":"http://schema.org","@type":"ListItem","position":1,"item":{"@context":"http://schema.org","@type":"Thing","@id":"https://www.rndsystems.com/","name":"Home"}},{"@context":"http://schema.org","@type":"ListItem","position":2,"item":{"@context":"http://schema.org","@type":"Thing","@id":"https://www.rndsystems.com/pathways","name":"Interactive Pathways & Processes"}},{"@context":"http://schema.org","@type":"ListItem","position":3,"item":{"@context":"http://schema.org","@type":"Thing","@id":"https://www.rndsystems.com/pathways/type-i-interferon-signaling-pathways","name":"Type I Interferon Signaling Pathways"}}]},"potentialaction":{"query":""}}]</script> <meta name="generator" content="Drupal 7 (https://www.drupal.org)" /> <link rel="shortlink" href="https://www.rndsystems.com/node/1094696" /> <meta property="og:site_name" content="www.rndsystems.com" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.rndsystems.com/pathways/type-i-interferon-signaling-pathways" /> <meta property="og:title" content="Type I Interferon Signaling Pathways" /> <meta property="og:image" content="https://resources.rndsystems.com/images/Social/2019RnDSystemslogoV.png" /> <style> @import url("https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/themes/base/minified/jquery.ui.core.min.css?snl6xl"); @import url("https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/themes/base/minified/jquery.ui.theme.min.css?snl6xl"); @import url("https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/themes/base/minified/jquery.ui.menu.min.css?snl6xl"); @import url("https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/themes/base/minified/jquery.ui.autocomplete.min.css?snl6xl"); @import url("https://www.rndsystems.com/modules/system/system.base.css?snl6xl"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/css/blueimp-gallery.min.css?snl6xl"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/css/datatables.css?snl6xl"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_quickorder_responsive/css/et_quickorder_responsive.css?snl6xl"); </style> <style> @import url("https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/themes/base/minified/jquery.ui.tooltip.min.css?snl6xl"); </style> <style> @import url("https://www.rndsystems.com/sites/rndsystems.com/modules/colorbox_node/colorbox_node.css?snl6xl"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_bestseller_products/css/styles.css?snl6xl"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_datasheet_page_alert/css/et_datasheet_page_alert.css?snl6xl"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_internationalization/css/et_internationalization.css?snl6xl"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_product_page_promo/css/et_product_page_promo.css?snl6xl"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_recommendation_engine/css/et_recommendation_engine.css?snl6xl"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_recommendation_engine/css/owl.carousel.min.css?snl6xl"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_recommendation_engine/css/owl.theme.default.min.css?snl6xl"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_searchbar_autocomplete/css/et_searchbar_autocomplete.css?snl6xl"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_top_scroll/css/top_scroll.css?snl6xl"); @import url("https://www.rndsystems.com/modules/field/theme/field.css?snl6xl"); @import url("https://www.rndsystems.com/modules/node/node.css?snl6xl"); @import url("https://www.rndsystems.com/sites/all/modules/contrib/views/css/views.css?snl6xl"); </style> <style>.infobox_section{border:thin solid black;padding:10px;margin-bottom:5px;} </style> <style> @import url("https://www.rndsystems.com/sites/all/modules/contrib/userInterface/ckeditor/css/ckeditor.css?snl6xl"); </style> <style> @import url("https://www.rndsystems.com/sites/all/modules/contrib/ctools/css/ctools.css?snl6xl"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_messages/et_messages_admin.css?snl6xl"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_messages/skins/default/et_messages.css?snl6xl"); @import url("https://www.rndsystems.com/sites/rndsystems.com/modules/et_pathways2/css/et_pathways.css?snl6xl"); </style> <style>#ind_pathways_adipokines___insulin_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/adipocytokines-insulin-signaling.png) center center;} #ind_pathways_apoptosis_signaling_pathway > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/apoptosis-signaling-pathways.png) center center;} #ind_pathways_b_cell_development_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/250x109_b-cell-development-pathways_tn_border-2.png) center center;} #ind_pathways_blood_coagulation_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/blood-coagulation-signaling.png) center center;} #ind_pathways_cardiotrophin_1_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/ct1-pathway-tn.jpg) center center;} #ind_pathways_cardiotrophin_like_cytokine_clc_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/clc-pathway-tn.jpg) center center;} #ind_pathways_chemokine_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/chemokine-signaling-pathways-thumb.png) center center;} #ind_pathways_chemokine_superfamily_pathway__human_mouse_ligand_receptor_interactions > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/chemokine-superfamily.png) center center;} #ind_pathways_cntf_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/cntf-pathway-tn.jpg) center center;} #ind_pathways_common_cytokine_receptor_gamma_chain_family_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/common-cytokine-receptor-gamma-chain-family.png) center center;} #ind_pathways_dendritic_cell_lineage_development_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/dendritic-cells-developmental-lineage-pathway_tn.png) center center;} #ind_pathways_fgf_family_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/dv_pathways_fgf-family-signaling-pathways-thumb.png?v=1) center center;} #ind_pathways_iga_producing_b_cells_in_the_intestine > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/iga-producing-b-cells.png) center center;} #ind_pathways_il_1_family_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-1-pathway-700x305.png?v=3) center center;} #ind_pathways_il_10_cytokine_family_signaling_pathway > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-10-thumbnail.png?t=2) center center;} #ind_pathways_il_11_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-11-pathway-tn.jpg?v=2) center center;} #ind_pathways_il_12_family_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-12-signaling-thumb.png) center center;} #ind_pathways_il_15_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-15-signaling-pathways.png) center center;} #ind_pathways_il_15_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-15-singaling-pathways-effects.png) center center;} #ind_pathways_il_17_family_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-17-signaling-pathways.png) center center;} #ind_pathways_il_2_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-2-signaling-pathways.png) center center;} #ind_pathways_il_2_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-2-signaling-pathways-effects.png) center center;} #ind_pathways_il_21_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-21-signaling-pathways.png) center center;} #ind_pathways_il_21_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-21-signaling-pathways-effects.png) center center;} #ind_pathways_il_27_p28_il_30_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-27-pathway-tn.jpg?v=2) center center;} #ind_pathways_il_31_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-31-pathway-tn.jpg?v=2) center center;} #ind_pathways_il_4_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-4-signaling-pathways.png) center center;} #ind_pathways_il_4_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-4-signaling-pathways-effects.png) center center;} #ind_pathways_il_6_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-6-pathway-tn.jpg) center center;} #ind_pathways_il_7_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-7signaling-pathways.png) center center;} #ind_pathways_il_7_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-7-signaling-pathways-effects.png) center center;} #ind_pathways_il_9_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-9-signaling-pathways.png) center center;} #ind_pathways_il_9_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/il-9-signaling-pathways-effects.png) center center;} #ind_pathways_inflammasome_activation_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/inflammasome-activation-pathways.png) center center;} #ind_pathways_innate_lymphoid_cell_differentiation_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/innate-lymphoid-cells-differentiation.jpg) center center;} #ind_pathways_lif_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/lif-pathway-tn.jpg) center center;} #ind_pathways_mdsc_mediated_mechanisms_of_immunosuppression > a:before{background:url(http://resources.rndsystems.com/images/Pathways/Thumbnails/mdsc-pathways-700x305.png) center center;} #ind_pathways_mechanisms_of_regulatory_t_cell_mediated_suppression > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/mechanisms-of-regulatory-t-cell-pathways-250x109-LG.png) center center;} #ind_pathways_mechanisms_of_tumor_associated_macrophage_tam_mediated_immunosuppression > a:before{background:url(https://resources.rndsystems.com/images/Pathways/Thumbnails/tam-pathways-700x269.png) center center;} #ind_pathways_mechanisms_of_tumor_derived_exosome_tex_mediated_immunosuppression > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/tex-pathway-700x269.jpg) center center;} #ind_pathways_natural_killer_cell_receptors__human_target_cell_–_nk_cell_ligand_receptor_interactions > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/250x109_nkcells_tn.png) center center;} #ind_pathways_neuropoietin_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/np-pathway-tn.jpg?v=2) center center;} #ind_pathways_nod_like_receptor_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/nod-like-receptors.png) center center;} #ind_pathways_oncostatin_m_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/osm-pathway-tn.jpg) center center;} #ind_pathways_pathogen_or_damage_activated_c_type_lectin_receptor_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/pathogen-damage-activated-c-type.png) center center;} #ind_pathways_t_cell_co_signaling_pathway__ligand_receptor_interactions > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/t-cell-co-signaling-tn4.png) center center;} #ind_pathways_tgf_beta_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/tgf-beta-signaling-pathways.png) center center;} #ind_pathways_th1_differentiation_pathway > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/th1-differentiation.png) center center;} #ind_pathways_th17_differentiation_pathway > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/th17-differentiation.png) center center;} #ind_pathways_th2_differentiation_pathway > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/th2-differentiation.png) center center;} #ind_pathways_tnf_superfamily_pathway__human_ligand_receptor_interactions___their_associated_functions > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/tnf-superfamily.png) center center;} #ind_pathways_toll_like_receptor_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/toll-like-receptor.png) center center;} #ind_pathways_type_i_interferon_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/interferons-type-1-250x109-tn.png) center center;} #ind_pathways_type_ii_interferon_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/interferons-type-2-250x109-tn.jpg) center center;} #ind_pathways_type_iii_interferon_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/interferons-type-3-250x109-tn.jpg) center center;} #ind_pathways_vegf___vegf_r2_signaling_pathways > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/vegf-vegf-r2-signaling-pathways.png) center center;} #ind_pathways_virus_detection_and_induction_of_antiviral_signaling_pathways_by_rig_i_like_receptors_rlr > a:before{background:url(//resources.rndsystems.com/images/Pathways/Thumbnails/rig-i-like-receptor.png) center center;} .pw-sprite{background-image:url(https://resources.rndsystems.com/images/Pathways/pathway-images/interferons_type_sprite.png);} .el-off1{width:46px;height:45px;background-position:-379px -269px;}.el-off1:hover{width:46px;height:45px;background-position:-225px -269px;}.el-hov1{width:46px;height:45px;background-position:-225px -269px;}.el-gray1{width:46px;height:45px;background-position:-85px -269px;} .el-hov2{color:#005696;border-bottom:dotted 1px;} .el-off3{width:68px;height:194px;background-position:-869px -30px;}.el-off3:hover{width:68px;height:194px;background-position:-698px -30px;}.el-hov3{width:68px;height:194px;background-position:-698px -30px;}.el-gray3{width:68px;height:194px;background-position:-531px -30px;} .el-hov4{color:#005696;border-bottom:dotted 1px;} .el-off5{width:47px;height:147px;background-position:-881px -297px;}.el-off5:hover{width:46px;height:147px;background-position:-713px -297px;}.el-hov5{width:46px;height:147px;background-position:-713px -297px;}.el-gray5{width:47px;height:147px;background-position:-542px -297px;} .el-hov6{color:#005696;border-bottom:dotted 1px;} .el-off7{width:36px;height:36px;background-position:-384px -370px;}.el-off7:hover{width:36px;height:36px;background-position:-230px -372px;}.el-hov7{width:36px;height:36px;background-position:-230px -372px;}.el-gray7{width:36px;height:36px;background-position:-90px -370px;} .el-hov8{color:#005696;border-bottom:dotted 1px;} .el-off9{width:36px;height:36px;background-position:-384px -479px;}.el-off9:hover{width:36px;height:36px;background-position:-231px -479px;}.el-hov9{width:36px;height:36px;background-position:-231px -479px;}.el-gray9{width:36px;height:36px;background-position:-89px -479px;} .el-hov10{color:#005696;border-bottom:dotted 1px;} .el-off11{width:36px;height:36px;background-position:-384px -60px;}.el-off11:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov11{width:36px;height:36px;background-position:-231px -61px;}.el-gray11{width:36px;height:36px;background-position:-90px -60px;} .el-hov12{color:#005696;border-bottom:dotted 1px;} .el-off13{width:36px;height:36px;background-position:-384px -60px;}.el-off13:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov13{width:36px;height:36px;background-position:-231px -61px;}.el-gray13{width:36px;height:36px;background-position:-90px -60px;} .el-hov14{color:#005696;border-bottom:dotted 1px;} .el-off15{width:36px;height:36px;background-position:-384px -60px;}.el-off15:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov15{width:36px;height:36px;background-position:-231px -61px;}.el-gray15{width:36px;height:36px;background-position:-90px -60px;} .el-hov16{color:#005696;border-bottom:dotted 1px;} .el-off17{width:36px;height:36px;background-position:-384px -60px;}.el-off17:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov17{width:36px;height:36px;background-position:-231px -61px;}.el-gray17{width:36px;height:36px;background-position:-90px -60px;} .el-hov18{color:#005696;border-bottom:dotted 1px;} .el-off19{width:56px;height:45px;background-position:-373px -778px;}.el-off19:hover{width:56px;height:45px;background-position:-222px -778px;}.el-hov19{width:56px;height:45px;background-position:-222px -778px;}.el-gray19{width:56px;height:45px;background-position:-83px -778px;} .el-hov20{color:#005696;border-bottom:dotted 1px;} .el-off21{width:66px;height:45px;background-position:-366px -161px;}.el-off21:hover{width:66px;height:45px;background-position:-215px -160px;}.el-hov21{width:66px;height:45px;background-position:-215px -160px;}.el-gray21{width:67px;height:46px;background-position:-74px -157px;} .el-hov22{color:#005696;border-bottom:dotted 1px;} .el-off23{width:36px;height:36px;background-position:-384px -60px;}.el-off23:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov23{width:36px;height:36px;background-position:-231px -61px;}.el-gray23{width:36px;height:36px;background-position:-90px -60px;} .el-hov24{color:#005696;border-bottom:dotted 1px;} .el-off25{width:36px;height:36px;background-position:-384px -60px;}.el-off25:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov25{width:36px;height:36px;background-position:-231px -61px;}.el-gray25{width:36px;height:36px;background-position:-90px -60px;} .el-hov26{color:#005696;border-bottom:dotted 1px;} .el-off27{width:66px;height:45px;background-position:-366px -161px;}.el-off27:hover{width:66px;height:45px;background-position:-215px -160px;}.el-hov27{width:66px;height:45px;background-position:-215px -160px;}.el-gray27{width:67px;height:46px;background-position:-74px -157px;} .el-hov28{color:#005696;border-bottom:dotted 1px;} .el-off29{width:36px;height:36px;background-position:-384px -60px;}.el-off29:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov29{width:36px;height:36px;background-position:-231px -61px;}.el-gray29{width:36px;height:36px;background-position:-90px -60px;} .el-hov30{color:#005696;border-bottom:dotted 1px;} .el-off31{width:36px;height:36px;background-position:-384px -60px;}.el-off31:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov31{width:36px;height:36px;background-position:-231px -61px;}.el-gray31{width:36px;height:36px;background-position:-90px -60px;} .el-hov32{color:#005696;border-bottom:dotted 1px;} .el-off33{width:36px;height:36px;background-position:-384px -60px;}.el-off33:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov33{width:36px;height:36px;background-position:-231px -61px;}.el-gray33{width:36px;height:36px;background-position:-90px -60px;} .el-hov34{color:#005696;border-bottom:dotted 1px;} .el-off35{width:36px;height:36px;background-position:-384px -60px;}.el-off35:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov35{width:36px;height:36px;background-position:-231px -61px;}.el-gray35{width:36px;height:36px;background-position:-90px -60px;} .el-hov36{color:#005696;border-bottom:dotted 1px;} .el-off37{width:36px;height:36px;background-position:-384px -60px;}.el-off37:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov37{width:36px;height:36px;background-position:-231px -61px;}.el-gray37{width:36px;height:36px;background-position:-90px -60px;} .el-hov38{color:#005696;border-bottom:dotted 1px;} .el-off39{width:36px;height:36px;background-position:-384px -60px;}.el-off39:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov39{width:36px;height:36px;background-position:-231px -61px;}.el-gray39{width:36px;height:36px;background-position:-90px -60px;} .el-hov40{color:#005696;border-bottom:dotted 1px;} .el-off41{width:36px;height:36px;background-position:-384px -60px;}.el-off41:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov41{width:36px;height:36px;background-position:-231px -61px;}.el-gray41{width:36px;height:36px;background-position:-90px -60px;} .el-hov42{color:#005696;border-bottom:dotted 1px;} .el-off43{width:36px;height:36px;background-position:-384px -60px;}.el-off43:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov43{width:36px;height:36px;background-position:-231px -61px;}.el-gray43{width:36px;height:36px;background-position:-90px -60px;} .el-hov44{color:#005696;border-bottom:dotted 1px;} .el-off49{width:36px;height:36px;background-position:-384px -60px;}.el-off49:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov49{width:36px;height:36px;background-position:-231px -61px;}.el-gray49{width:36px;height:36px;background-position:-90px -60px;} .el-hov50{color:#005696;border-bottom:dotted 1px;} .el-off51{width:36px;height:36px;background-position:-384px -60px;} .el-hov52{color:#005696;border-bottom:dotted 1px;} .el-off53{width:36px;height:36px;background-position:-384px -60px;}.el-off53:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov53{width:36px;height:36px;background-position:-231px -61px;}.el-gray53{width:36px;height:36px;background-position:-90px -60px;} .el-hov54{color:#005696;border-bottom:dotted 1px;} .el-off55{width:36px;height:36px;background-position:-384px -60px;} .el-hov56{color:#005696;border-bottom:dotted 1px;} .el-off57{width:36px;height:36px;background-position:-384px -60px;}.el-off57:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov57{width:36px;height:36px;background-position:-231px -61px;}.el-gray57{width:36px;height:36px;background-position:-90px -60px;} .el-hov58{color:#005696;border-bottom:dotted 1px;} .el-off59{width:36px;height:36px;background-position:-384px -60px;}.el-off59:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov59{width:36px;height:36px;background-position:-231px -61px;}.el-gray59{width:36px;height:36px;background-position:-90px -60px;} .el-hov60{color:#005696;border-bottom:dotted 1px;} .el-off61{width:36px;height:36px;background-position:-384px -60px;}.el-off61:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov61{width:36px;height:36px;background-position:-231px -61px;}.el-gray61{width:36px;height:36px;background-position:-90px -60px;} .el-hov62{color:#005696;border-bottom:dotted 1px;} .el-off63{width:36px;height:36px;background-position:-384px -60px;}.el-off63:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov63{width:36px;height:36px;background-position:-231px -61px;}.el-gray63{width:36px;height:36px;background-position:-90px -60px;} .el-hov64{color:#005696;border-bottom:dotted 1px;} .el-off65{width:36px;height:36px;background-position:-384px -60px;}.el-off65:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov65{width:36px;height:36px;background-position:-231px -61px;}.el-gray65{width:36px;height:36px;background-position:-90px -60px;} .el-hov66{color:#005696;border-bottom:dotted 1px;} .el-off67{width:36px;height:36px;background-position:-384px -60px;}.el-off67:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov67{width:36px;height:36px;background-position:-231px -61px;}.el-gray67{width:36px;height:36px;background-position:-90px -60px;} .el-hov68{color:#005696;border-bottom:dotted 1px;} .el-off69{width:36px;height:36px;background-position:-384px -60px;}.el-off69:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov69{width:36px;height:36px;background-position:-231px -61px;}.el-gray69{width:36px;height:36px;background-position:-90px -60px;} .el-hov70{color:#005696;border-bottom:dotted 1px;} .el-off71{width:36px;height:36px;background-position:-384px -60px;}.el-off71:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov71{width:36px;height:36px;background-position:-231px -61px;}.el-gray71{width:36px;height:36px;background-position:-90px -60px;} .el-hov72{color:#005696;border-bottom:dotted 1px;} .el-off75{width:36px;height:36px;background-position:-384px -60px;}.el-off75:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov75{width:36px;height:36px;background-position:-231px -61px;}.el-gray75{width:36px;height:36px;background-position:-90px -60px;} .el-hov76{color:#005696;border-bottom:dotted 1px;} .el-off77{width:36px;height:36px;background-position:-384px -60px;}.el-off77:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov77{width:36px;height:36px;background-position:-231px -61px;}.el-gray77{width:36px;height:36px;background-position:-90px -60px;} .el-hov78{color:#005696;border-bottom:dotted 1px;} .el-off79{width:36px;height:36px;background-position:-384px -60px;}.el-off79:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov79{width:36px;height:36px;background-position:-231px -61px;}.el-gray79{width:36px;height:36px;background-position:-90px -60px;} .el-hov80{color:#005696;border-bottom:dotted 1px;} .el-off81{width:36px;height:36px;background-position:-384px -60px;}.el-off81:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov81{width:36px;height:36px;background-position:-231px -61px;}.el-gray81{width:36px;height:36px;background-position:-90px -60px;} .el-hov82{color:#005696;border-bottom:dotted 1px;} .el-off83{width:36px;height:36px;background-position:-384px -60px;}.el-off83:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov83{width:36px;height:36px;background-position:-231px -61px;}.el-gray83{width:36px;height:36px;background-position:-90px -60px;} .el-hov84{color:#005696;border-bottom:dotted 1px;} .el-off85{width:36px;height:36px;background-position:-384px -60px;}.el-off85:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov85{width:36px;height:36px;background-position:-231px -61px;}.el-gray85{width:36px;height:36px;background-position:-90px -60px;} .el-hov86{color:#005696;border-bottom:dotted 1px;} .el-off87{width:36px;height:36px;background-position:-384px -60px;}.el-off87:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov87{width:36px;height:36px;background-position:-231px -61px;}.el-gray87{width:36px;height:36px;background-position:-90px -60px;} .el-hov88{color:#005696;border-bottom:dotted 1px;} .el-off90{width:36px;height:36px;background-position:-384px -60px;}.el-off90:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov90{width:36px;height:36px;background-position:-231px -61px;}.el-gray90{width:36px;height:36px;background-position:-90px -60px;} .el-hov91{color:#005696;border-bottom:dotted 1px;} .el-off92{width:36px;height:36px;background-position:-384px -60px;}.el-off92:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov92{width:36px;height:36px;background-position:-231px -61px;}.el-gray92{width:36px;height:36px;background-position:-90px -60px;} .el-hov93{color:#005696;border-bottom:dotted 1px;} .el-off94{width:36px;height:36px;background-position:-384px -60px;}.el-off94:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov94{width:36px;height:36px;background-position:-231px -61px;}.el-gray94{width:36px;height:36px;background-position:-90px -60px;} .el-hov95{color:#005696;border-bottom:dotted 1px;} .el-off98{width:36px;height:36px;background-position:-384px -60px;}.el-off98:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov98{width:36px;height:36px;background-position:-231px -61px;}.el-gray98{width:36px;height:36px;background-position:-90px -60px;} .el-hov99{color:#005696;border-bottom:dotted 1px;} .el-off100{width:36px;height:36px;background-position:-384px -60px;}.el-off100:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov100{width:36px;height:36px;background-position:-231px -61px;}.el-gray100{width:36px;height:36px;background-position:-90px -60px;} .el-hov101{color:#005696;border-bottom:dotted 1px;} .el-off102{width:36px;height:36px;background-position:-384px -60px;}.el-off102:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov102{width:36px;height:36px;background-position:-231px -61px;}.el-gray102{width:36px;height:36px;background-position:-90px -60px;} .el-hov103{color:#005696;border-bottom:dotted 1px;} .el-off105{width:66px;height:45px;background-position:-366px -161px;}.el-off105:hover{width:66px;height:45px;background-position:-215px -160px;}.el-hov105{width:66px;height:45px;background-position:-215px -160px;}.el-gray105{width:67px;height:46px;background-position:-74px -157px;} .el-hov106{color:#005696;border-bottom:dotted 1px;} .el-off108{width:36px;height:36px;background-position:-384px -60px;}.el-off108:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov108{width:36px;height:36px;background-position:-231px -61px;}.el-gray108{width:36px;height:36px;background-position:-90px -60px;} .el-hov109{color:#005696;border-bottom:dotted 1px;} .el-off110{width:36px;height:36px;background-position:-384px -60px;}.el-off110:hover{width:36px;height:36px;background-position:-231px -61px;}.el-hov110{width:36px;height:36px;background-position:-231px -61px;}.el-gray110{width:36px;height:36px;background-position:-90px -60px;} .el-hov111{color:#005696;border-bottom:dotted 1px;} .el-hov112{color:#005696;border-bottom:dotted 1px;} .el-hov113{color:#005696;border-bottom:dotted 1px;} .el-hov114{color:#005696;border-bottom:dotted 1px;} .el-hov115{color:#005696;border-bottom:dotted 1px;} </style> <style> @import url("https://www.rndsystems.com/system/files/honeypot/honeypot.css?snl6xl"); @import url("https://www.rndsystems.com/sites/all/modules/contrib/webform/css/webform.css?snl6xl"); </style> <link type="text/css" rel="stylesheet" href="https://resources.rndsystems.com/bootstrap/bootstrap.min.css" media="all" /> <style> @import url("https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/css/style.css?snl6xl"); </style>   <script defer="defer" src="https://www.rndsystems.com/sites/rndsystems.com/files/google_tag/language/google_tag.en.script.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/jquery/2.1/jquery.min.js?v=2.1.4"></script> <script>jQuery.migrateMute=true;jQuery.migrateTrace=false;</script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/jquery-migrate/1/jquery-migrate.min.js?v=1"></script> <script src="https://www.rndsystems.com/misc/jquery-extend-3.4.0.js?v=2.1.4"></script> <script src="https://www.rndsystems.com/misc/jquery-html-prefilter-3.5.0-backport.js?v=2.1.4"></script> <script src="https://www.rndsystems.com/misc/jquery.once.js?v=1.2"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/ui/minified/jquery.ui.core.min.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/ui/minified/jquery.ui.widget.min.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/misc/drupal.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/jquery_cookie.js?v=1.2"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/ui/minified/jquery.ui.position.min.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/misc/ui/jquery.ui.position-1.13.0-backport.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/ui/minified/jquery.ui.menu.min.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/ui/minified/jquery.ui.autocomplete.min.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_searchbar/js/searchbar_autocomplete.js?v=1"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/jQuery_cycle2.js?v=2.1.6"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/jquery.blueimp-gallery.min.js?v=2.33.0"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/blueimp_et_handler.js?v=2.33.0"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/jquery_hoverintent.js?v=1.8.1"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/jquery_lazyload.js?v=1.9.1"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/jquery_datatables.js?v=1.9.4"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/jquery_tablesorter.js?v=2"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/underscore.js?v=1.6.0"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/external/jquery.cookie.js?v=67fb34f6a866c40d0570"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/jquery.form/4/jquery.form.min.js?v=4.2.1"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_quickorder_responsive/js/et_quickorder_responsive.js?v=1.0.32"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/ui/minified/jquery.ui.effect.min.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/ui/minified/jquery.ui.effect-highlight.min.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/ui/minified/jquery.ui.tooltip.min.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/misc/form-single-submit.js?v=7.98"></script> <script src="https://www.rndsystems.com/misc/ajax.js?v=7.98"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/js/jquery_update.js?v=0.0.1"></script> <script src="https://resources.rndsystems.com/bootstrap/bootstrap.min.js"></script> <script defer="defer" src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_onecall/js/et_onecall.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/modules/contrib/fields/entityreference/js/entityreference.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_internationalization/js/et_internationalization.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/jQuery_et.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_recommendation_engine/js/et_recommendation_engine.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_recommendation_engine/js/owl.carousel.min.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_top_scroll/js/top_scroll.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/modules/contrib/marketo_ma/js/marketo_ma.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/libraries/colorbox/jquery.colorbox-min.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/libraries/DOMPurify/purify.min.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/modules/contrib/colorbox/js/colorbox.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/modules/contrib/colorbox/js/colorbox_load.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_cookie_policy/js/et_cookie_policy.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_internationalization/js/rnd_distributors.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_search/json_viewer/js/jsonviewer.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_searchbar/js/et_searchbar.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/themes/bootstrap/js/misc/_progress.js?v=7.98"></script> <script src="https://www.rndsystems.com/sites/all/modules/et_commerce/et_atc_blocks/js/et_atc_blocks.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/modules/et_commerce/et_atc_blocks/js/et_atc_cart_summary.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_combined_seo/js/et_combined_seo.js?snl6xl"></script> <script>var dataLayer = dataLayer || []; dataLayer.push({"email": ""});</script> <script>var dataLayer = dataLayer || [] dataLayer.push({"event":"userRole","userRole":"anonymous user"});</script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_messages/et_messages.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/et_pathways2/js/new_pathways.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/modules/contrib/webform/js/webform.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/js/rnd.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/js/et_mobile_theme.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/js/rnd_menu.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/js/jquery.livequery.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/js/jquery.cluetip.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/js/distributors.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/js/et_atc_blocks.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/js/blueimp.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/colorbox_node/colorbox_node.js?snl6xl"></script> <script src="https://www.rndsystems.com/sites/all/themes/bootstrap/js/misc/ajax.js?snl6xl"></script> <script>jQuery.extend(Drupal.settings, {"basePath":"\/","pathPrefix":"","setHasJsCookie":0,"ajaxPageState":{"theme":"RnD_2017","theme_token":"w9lzX_L4P4roogGtDKQo7Ybb-hIIFeqcRaZ47GyA4L8","jquery_version":"2.1","js":{"0":1,"sites\/all\/themes\/bootstrap\/js\/bootstrap.js":1,"public:\/\/google_tag\/language\/google_tag.en.script.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/jquery\/2.1\/jquery.min.js":1,"1":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/jquery-migrate\/1\/jquery-migrate.min.js":1,"misc\/jquery-extend-3.4.0.js":1,"misc\/jquery-html-prefilter-3.5.0-backport.js":1,"misc\/jquery.once.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.core.min.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.widget.min.js":1,"misc\/drupal.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jquery_cookie.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.position.min.js":1,"misc\/ui\/jquery.ui.position-1.13.0-backport.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.menu.min.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.autocomplete.min.js":1,"sites\/all\/modules\/enterprise-tech\/et_searchbar\/js\/searchbar_autocomplete.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jQuery_cycle2.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jquery.blueimp-gallery.min.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/blueimp_et_handler.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jquery_hoverintent.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jquery_lazyload.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jquery_datatables.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jquery_tablesorter.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/underscore.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/external\/jquery.cookie.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/jquery.form\/4\/jquery.form.min.js":1,"sites\/all\/modules\/enterprise-tech\/et_quickorder_responsive\/js\/et_quickorder_responsive.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.effect.min.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.effect-highlight.min.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.tooltip.min.js":1,"misc\/form-single-submit.js":1,"misc\/ajax.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/js\/jquery_update.js":1,"https:\/\/resources.rndsystems.com\/bootstrap\/bootstrap.min.js":1,"sites\/all\/modules\/enterprise-tech\/et_onecall\/js\/et_onecall.js":1,"sites\/all\/modules\/contrib\/fields\/entityreference\/js\/entityreference.js":1,"sites\/all\/modules\/enterprise-tech\/et_internationalization\/js\/et_internationalization.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jQuery_et.js":1,"sites\/all\/modules\/enterprise-tech\/et_recommendation_engine\/js\/et_recommendation_engine.js":1,"sites\/all\/modules\/enterprise-tech\/et_recommendation_engine\/js\/owl.carousel.min.js":1,"sites\/all\/modules\/enterprise-tech\/et_top_scroll\/js\/top_scroll.js":1,"sites\/all\/modules\/contrib\/marketo_ma\/js\/marketo_ma.js":1,"sites\/all\/libraries\/colorbox\/jquery.colorbox-min.js":1,"sites\/all\/libraries\/DOMPurify\/purify.min.js":1,"sites\/all\/modules\/contrib\/colorbox\/js\/colorbox.js":1,"sites\/all\/modules\/contrib\/colorbox\/js\/colorbox_load.js":1,"sites\/all\/modules\/enterprise-tech\/et_cookie_policy\/js\/et_cookie_policy.js":1,"sites\/all\/modules\/enterprise-tech\/et_internationalization\/js\/rnd_distributors.js":1,"sites\/all\/modules\/enterprise-tech\/et_search\/json_viewer\/js\/jsonviewer.js":1,"sites\/all\/modules\/enterprise-tech\/et_searchbar\/js\/et_searchbar.js":1,"sites\/all\/themes\/bootstrap\/js\/misc\/_progress.js":1,"sites\/all\/modules\/et_commerce\/et_atc_blocks\/js\/et_atc_blocks.js":1,"sites\/all\/modules\/et_commerce\/et_atc_blocks\/js\/et_atc_cart_summary.js":1,"sites\/all\/modules\/enterprise-tech\/et_combined_seo\/js\/et_combined_seo.js":1,"2":1,"3":1,"sites\/all\/modules\/enterprise-tech\/et_messages\/et_messages.js":1,"sites\/rndsystems.com\/modules\/et_pathways2\/js\/new_pathways.js":1,"sites\/all\/modules\/contrib\/webform\/js\/webform.js":1,"sites\/rndsystems.com\/themes\/RnD_2017\/js\/rnd.js":1,"sites\/rndsystems.com\/themes\/RnD_2017\/js\/et_mobile_theme.js":1,"sites\/rndsystems.com\/themes\/RnD_2017\/js\/rnd_menu.js":1,"sites\/rndsystems.com\/themes\/RnD_2017\/js\/jquery.livequery.js":1,"sites\/rndsystems.com\/themes\/RnD_2017\/js\/jquery.cluetip.js":1,"sites\/rndsystems.com\/themes\/RnD_2017\/js\/distributors.js":1,"sites\/rndsystems.com\/themes\/RnD_2017\/js\/et_atc_blocks.js":1,"sites\/rndsystems.com\/themes\/RnD_2017\/js\/blueimp.js":1,"sites\/rndsystems.com\/modules\/colorbox_node\/colorbox_node.js":1,"sites\/all\/themes\/bootstrap\/js\/misc\/ajax.js":1},"css":{"misc\/ui\/jquery.ui.core.css":1,"misc\/ui\/jquery.ui.theme.css":1,"misc\/ui\/jquery.ui.menu.css":1,"misc\/ui\/jquery.ui.autocomplete.css":1,"modules\/system\/system.base.css":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/css\/blueimp-gallery.min.css":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/css\/datatables.css":1,"sites\/all\/modules\/enterprise-tech\/et_quickorder_responsive\/css\/et_quickorder_responsive.css":1,"misc\/ui\/jquery.ui.tooltip.css":1,"sites\/rndsystems.com\/modules\/colorbox_node\/colorbox_node.css":1,"sites\/all\/modules\/enterprise-tech\/et_bestseller_products\/css\/styles.css":1,"sites\/all\/modules\/enterprise-tech\/et_datasheet_page_alert\/css\/et_datasheet_page_alert.css":1,"sites\/all\/modules\/enterprise-tech\/et_internationalization\/css\/et_internationalization.css":1,"sites\/all\/modules\/enterprise-tech\/et_product_page_promo\/css\/et_product_page_promo.css":1,"sites\/all\/modules\/enterprise-tech\/et_recommendation_engine\/css\/et_recommendation_engine.css":1,"sites\/all\/modules\/enterprise-tech\/et_recommendation_engine\/css\/owl.carousel.min.css":1,"sites\/all\/modules\/enterprise-tech\/et_recommendation_engine\/css\/owl.theme.default.min.css":1,"sites\/all\/modules\/enterprise-tech\/et_searchbar_autocomplete\/css\/et_searchbar_autocomplete.css":1,"sites\/all\/modules\/enterprise-tech\/et_top_scroll\/css\/top_scroll.css":1,"modules\/field\/theme\/field.css":1,"modules\/node\/node.css":1,"sites\/all\/modules\/contrib\/views\/css\/views.css":1,"0":1,"sites\/all\/modules\/contrib\/userInterface\/ckeditor\/css\/ckeditor.css":1,"sites\/all\/modules\/contrib\/ctools\/css\/ctools.css":1,"sites\/all\/modules\/enterprise-tech\/et_messages\/et_messages_admin.css":1,"sites\/all\/modules\/enterprise-tech\/et_messages\/skins\/default\/et_messages.css":1,"sites\/rndsystems.com\/modules\/et_pathways2\/css\/et_pathways.css":1,"sites\/rndsystems.com\/modules\/et_pathways2\/css\/et_pathways2.css":1,"1":1,"2":1,"3":1,"4":1,"5":1,"6":1,"7":1,"8":1,"9":1,"10":1,"11":1,"12":1,"13":1,"14":1,"15":1,"16":1,"17":1,"18":1,"19":1,"20":1,"21":1,"22":1,"23":1,"24":1,"25":1,"26":1,"27":1,"28":1,"29":1,"30":1,"31":1,"32":1,"33":1,"34":1,"35":1,"36":1,"37":1,"38":1,"39":1,"40":1,"41":1,"42":1,"43":1,"44":1,"45":1,"46":1,"47":1,"48":1,"49":1,"50":1,"51":1,"52":1,"53":1,"54":1,"55":1,"56":1,"57":1,"58":1,"59":1,"60":1,"61":1,"62":1,"63":1,"64":1,"65":1,"66":1,"67":1,"68":1,"69":1,"70":1,"71":1,"72":1,"73":1,"74":1,"75":1,"76":1,"77":1,"78":1,"79":1,"80":1,"81":1,"82":1,"83":1,"84":1,"85":1,"86":1,"87":1,"88":1,"89":1,"90":1,"91":1,"92":1,"93":1,"94":1,"95":1,"96":1,"97":1,"98":1,"99":1,"100":1,"101":1,"102":1,"103":1,"104":1,"105":1,"106":1,"107":1,"108":1,"109":1,"110":1,"111":1,"112":1,"113":1,"114":1,"115":1,"116":1,"117":1,"118":1,"119":1,"120":1,"121":1,"122":1,"123":1,"124":1,"125":1,"126":1,"127":1,"128":1,"129":1,"130":1,"131":1,"132":1,"133":1,"134":1,"135":1,"136":1,"137":1,"138":1,"139":1,"140":1,"141":1,"142":1,"143":1,"144":1,"145":1,"146":1,"147":1,"148":1,"149":1,"150":1,"151":1,"152":1,"153":1,"154":1,"155":1,"156":1,"157":1,"158":1,"159":1,"160":1,"161":1,"162":1,"private:\/\/honeypot\/honeypot.css":1,"sites\/all\/modules\/contrib\/webform\/css\/webform.css":1,"https:\/\/resources.rndsystems.com\/bootstrap\/drupal-bootstrap.min.css":1,"https:\/\/resources.rndsystems.com\/bootstrap\/bootstrap.min.css":1,"sites\/rndsystems.com\/themes\/RnD_2017\/css\/style.css":1}},"colorbox":{"transition":"elastic","speed":"350","opacity":"0.85","slideshow":false,"slideshowAuto":true,"slideshowSpeed":"2500","slideshowStart":"start slideshow","slideshowStop":"stop slideshow","current":"{current} of {total}","previous":"\u00ab Prev","next":"Next \u00bb","close":"Close","overlayClose":true,"returnFocus":true,"maxWidth":"98%","maxHeight":"98%","initialWidth":"300","initialHeight":"250","fixed":true,"scrolling":false,"mobiledetect":true,"mobiledevicewidth":"480px","file_public_path":"\/sites\/rndsystems.com\/files","specificPagesDefaultValue":"admin*\nimagebrowser*\nimg_assist*\nimce*\nnode\/add\/*\nnode\/*\/edit\nprint\/*\nprintpdf\/*\nsystem\/ajax\nsystem\/ajax\/*"},"country_name":"United States","et_internationalization":{"social":" \u003Ctable\u003E\n \u003Ctr\u003E\n \u003Ctd\u003E\u003Ca href=\u0022http:\/\/www.facebook.com\/RnDSystems\u0022 target=\u0022_blank\u0022\u003E\u003Cdiv class=\u0022fp_social_facebook\u0022\u003E\u003C\/div\u003E\u003C\/a\u003E\u003C\/td\u003E\n \u003Ctd\u003E\u003Ca href=\u0022http:\/\/www.facebook.com\/RnDSystems\u0022 target=\u0022_blank\u0022\u003EFind us on Facebook\u003C\/div\u003E\u003C\/a\u003E\u003C\/td\u003E\n \u003C\/tr\u003E\n \u003Ctr\u003E\n \u003Ctd\u003E\u003Ca href=\u0022http:\/\/www.twitter.com\/RnDSystems\u0022 target=\u0022_blank\u0022\u003E\u003Cdiv class=\u0022fp_social_twitter social\u0022\u003E\u003C\/div\u003E\u003C\/a\u003E\u003C\/td\u003E\n \u003Ctd\u003E\u003Ca href=\u0022http:\/\/www.twitter.com\/RnDSystems\u0022 target=\u0022_blank\u0022\u003E\u003Cdiv class=\u0022social_text\u0022\u003EFollow us on Twitter\u003C\/div\u003E\u003C\/a\u003E\u003C\/td\u003E\n \u003C\/tr\u003E\n \u003Ctr\u003E\n \u003Ctd\u003E\u003Ca href=\u0022https:\/\/www.youtube.com\/user\/RnDSystems\u0022 target=\u0022_blank\u0022\u003E\u003Cdiv class=\u0022fp_social_youtube social\u0022\u003E\u003C\/div\u003E\u003C\/a\u003E\u003C\/td\u003E\n \u003Ctd\u003E\u003Ca href=\u0022https:\/\/www.youtube.com\/user\/RnDSystems\u0022 target=\u0022_blank\u0022\u003E\u003Cdiv class=\u0022social_text\u0022\u003EWatch us on YouTube\u003C\/div\u003E\u003C\/a\u003E\u003C\/td\u003E\n \u003C\/tr\u003E\n \u003Ctr\u003E\n \u003Ctd\u003E\u003Ca href=\u0022http:\/\/www.linkedin.com\/company\/r\u0026amp;d-systems\u0022 target=\u0022_blank\u0022\u003E\u003Cdiv class=\u0022fp_social_linkedin social\u0022\u003E\u003C\/div\u003E\u003C\/a\u003E\u003C\/td\u003E\n \u003Ctd\u003E\u003Ca href=\u0022http:\/\/www.linkedin.com\/company\/r\u0026amp;d-systems\u0022 target=\u0022_blank\u0022\u003E\u003Cdiv class=\u0022social_text\u0022\u003EConnect with us on LinkedIn\u003C\/div\u003E\u003C\/a\u003E\u003C\/td\u003E\n \u003C\/tr\u003E\n \u003C\/table\u003E","distphone":"(65) 62720788"},"et_onecall":{"active":"true"},"et_searchbar":{"min_chars":"2"},"etMessages":{"position":"center","vertical":"0","horizontal":"10","fixed":1,"width":"400px","autoclose":0,"opendelay":"0.3","disable_autoclose":0,"show_countdown":1,"hover_autoclose":1,"popin":{"effect":"fadeIn","duration":"slow"},"popout":{"effect":"fadeIn","duration":"slow"}},"urlIsAjaxTrusted":{"\/pathways\/type-i-interferon-signaling-pathways":true},"et_quickorder_responsive":{"enabled":false,"show_cart":"0","display_price":"0","isDistributor":false},"colorbox_node":{"width":"600px","height":"600px"},"bootstrap":{"anchorsFix":"0","anchorsSmoothScrolling":"0","formHasError":1,"popoverEnabled":1,"popoverOptions":{"animation":1,"html":0,"placement":"right","selector":"","trigger":"click","triggerAutoclose":1,"title":"","content":"","delay":0,"container":"body"},"tooltipEnabled":1,"tooltipOptions":{"animation":1,"html":0,"placement":"auto left","selector":"","trigger":"hover focus","delay":0,"container":"body"}}});</script>                <link rel="apple-touch-icon" sizes="180x180" href="https://resources.rndsystems.com/images/favicons/apple-touch-icon.png"> <link rel="icon" type="image/png" sizes="32x32" href="https://resources.rndsystems.com/images/favicons/favicon32x32.png"> <link rel="icon" type="image/png" sizes="16x16" href="https://resources.rndsystems.com/images/favicons/favicon16x16.png"> <link rel="manifest" href="https://resources.rndsystems.com/images/favicons/site.webmanifest"> <link rel="shortcut icon" href="https://resources.rndsystems.com/images/favicons/favicon.ico"> <meta name="apple-mobile-web-app-title" content="R&D Systems"> <meta name="application-name" content="R&D Systems"> <meta name="msapplication-TileColor" content="#ffffff"> <meta name="msapplication-config" content="https://resources.rndsystems.com/images/favicons/browserconfig.xml"> <meta name="theme-color" content="#ffffff"> </head> <body class="html not-front not-logged-in no-sidebars page-node page-node- page-node-1094696 node-type-pathways i18n-en">     <div id="skip-link"> <a href="#main-content" class="element-invisible element-focusable">Skip to main content</a> </div> <div class="region region-page-top"> <noscript aria-hidden="true"><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5JK4G7" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> </div> <header id="header" role="banner">   <div id="bb_container"> <div id="brands_bar"> <div class="region region-brands-bar"> <section id="block-bt-brands-bar-bt-brands-bar" class="block block-bt-brands-bar clearfix"> <li class="bb_biotechne"><a href="https://www.bio-techne.com" rel="noopener noreferrer" target="_blank" aria-label="Bio-Techne"></a></li><li class="bb_rndsystems active"><a href="https://www.rndsystems.com" rel="noopener noreferrer" target="_self" aria-label="R&D Systems"></a></li><li class="bb_novusbio"><a href="https://www.novusbio.com" rel="noopener noreferrer" target="_blank" aria-label="Novus Biologicals"></a></li><li class="bb_tocris"><a href="https://www.tocris.com" rel="noopener noreferrer" target="_blank" aria-label="Tocris Bioscience"></a></li><li class="bb_proteinsimple"><a href="https://www.bio-techne.com/brands/proteinsimple" rel="noopener noreferrer" target="_blank" aria-label="ProteinSimple"></a></li><li class="bb_biospacific"><a href="https://www.biospacific.com" rel="noopener noreferrer" target="_blank" aria-label="BiosPacific"></a></li><li class="bb_cliniqa"><a href="https://www.cliniqa.com" rel="noopener noreferrer" target="_blank" aria-label="Cliniqa"></a></li><li class="bb_acd"><a href="https://acdbio.com/ " rel="noopener noreferrer" target="_blank" aria-label="ACD"></a></li><li class="bb_rndheme"><a href="https://www.rndheme.com" rel="noopener noreferrer" target="_blank" aria-label="R&D Heme"></a></li> </section> </div> </div> </div> <div id="hd_container"> <div id="logo_block"> <section id="block-logo-block-logo" class="block block-logo-block clearfix"> <a href="/" title="RnD Systems" class="active"></a> </section> </div> <div id="search_bar"> <div class="region region-search-bar"> <section id="block-et-searchbar-et-searchbar-bar" class="block block-et-searchbar clearfix"> <form name="et_searchbar" method="GET" action="/search" class="search_form"><div class="et_searchbar"> <input autocomplete="off" name="keywords" type="text" class="et_searchbar_wide et_searchbar_default" value="" placeholder="Search keyword, molecule name, target, catalog number, or product type" data-default="" spellcheck="false"/><input type="submit" value="" class="search_btn fp_mag_glass_wideSearch"></div></form> </section> </div> </div> <div id="cart_menu_mobile" class="atc_cart_summary_icon"></div> <div id="account_menu_mobile"></div> <div id="account_menu"> <div class="region region-account-menu"> <section id="block-et-internationalization-country-dropdown" class="block block-et-internationalization clearfix"> <div id="internationalization_country_select"> <div class="internationalization_drop"></div> </div> </section> <section id="block-et-internationalization-sign-in" class="block block-et-internationalization clearfix"> <div id="sign_in"><a href="/user/login" rel="nofollow"><noscript>Account</noscript></a></div> </section> <section id="block-et-cookie-policy-cookie-policy" class="block block-et-cookie-policy clearfix"> <div></div> </section> <section id="block-et-atc-blocks-et-atc-cart-summary" class="block block-et-atc-blocks clearfix"> <ul class="menu nav"> <li class="first last leaf active"><div class="atc_blocks_items_in_cart" style="display:none;"></div></li> </ul> </section> </div> </div> </div> <div id="mm_container"> <div id="main_menu_mobile"></div> <nav id="main_menu"> <div class="region region-main-menu"> <section id="block-menu-menu-master-menu" class="block block-menu clearfix"> <ul class="menu nav"><li class="first expanded dropdown"><a href="/products" id="menu-master-menu-116406" data-target="#">Products <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu"><li class="first expanded dropdown"><span id="menu-master-menu-116611" data-target="#" class="nolink" tabindex="0">Products by Category <span class="caret"></span></span><div class="menu_toggle"></div><ul class="third-level-menu"><li class="first leaf"><a href="/products/proteins" id="menu-master-menu-121156">Recombinant Proteins</a></li> <li class="leaf"><a href="/products/good-manufacturing-practices-gmp-grade-proteins" id="menu-master-menu-116631">GMP Proteins</a></li> <li class="leaf"><a href="/products/antibodies" id="menu-master-menu-120916">Antibodies</a></li> <li class="leaf"><a href="/products/elisas" id="menu-master-menu-120906">ELISAs</a></li> <li class="leaf"><a href="/products/cometassay" id="menu-master-menu-120986">CometAssay</a></li> <li class="leaf"><a href="/products/luminex-assays-and-high-performance-assays" id="menu-master-menu-121061">Luminex Assays</a></li> <li class="leaf"><a href="/products/luminex-instrumentation" id="menu-master-menu-120461">Luminex Instruments</a></li> <li class="leaf"><a href="/products/cell-culture" id="menu-master-menu-121146">Cell Culture</a></li> <li class="leaf"><a href="/products/stem-cell-products" id="menu-master-menu-122806">Stem Cell Products</a></li> <li class="leaf"><a href="/products/small-molecules-peptides" id="menu-master-menu-116706">Small Molecules & Peptides</a></li> <li class="leaf"><a href="/products/enzymes" id="menu-master-menu-121116">Enzymes</a></li> <li class="leaf"><a href="/products/elispot-kits-fluorospot-kits" id="menu-master-menu-116731">ELISpots</a></li> <li class="leaf"><a href="/products/cdna-clones" id="menu-master-menu-116736">cDNA Clones</a></li> <li class="leaf"><a href="/products/flow-cytometry-workflow-solutions" id="menu-master-menu-120941">Flow Cytometry Workflow Solutions</a></li> <li class="last leaf"><a href="/products/proteome-profiler-antibody-arrays" id="menu-master-menu-116746">Proteome Profiler Antibody Arrays</a></li> </ul></li> <li class="expanded dropdown"><span id="menu-master-menu-116616" data-target="#" class="nolink" tabindex="0">Products by Research Area <span class="caret"></span></span><div class="menu_toggle"></div><ul class="third-level-menu"><li class="first leaf"><a href="/products/cell-therapy" id="menu-master-menu-116751">Cell Therapy</a></li> <li class="leaf"><a href="/products/immunotherapy" id="menu-master-menu-116761">Immunotherapy</a></li> <li class="leaf"><a href="/research-area/cancer" id="menu-master-menu-116771">Cancer</a></li> <li class="leaf"><a href="/research-area/immunology" id="menu-master-menu-116781">Immunology</a></li> <li class="leaf"><a href="/research-area/neuroscience" id="menu-master-menu-116791">Neuroscience</a></li> <li class="leaf"><a href="/products/cell-proliferation-viability-apoptosis" id="menu-master-menu-116821">Apoptosis and Cell Viability</a></li> <li class="leaf"><a href="/products/activity-assays-reagents" id="menu-master-menu-116831">Biological Activity Assays</a></li> <li class="leaf"><a href="/research-area/glycobiology" id="menu-master-menu-116836">Glycobiology</a></li> <li class="leaf"><a href="/research-area/cardiovascular-biology" id="menu-master-menu-116851">Cardiovascular Biology</a></li> <li class="last leaf"><a href="/products/ubiquitin-related-products" id="menu-master-menu-122741">Ubiquitin</a></li> </ul></li> <li class="last leaf menu-background two-column menu_products_image"><div class="menu_image_mask"><img loading="lazy" src="https://resources.rndsystems.com/images/navigation/products05-2017b.jpg" alt="Our Products" /></div><span class="btn nolink" tabindex="0">Our Products</span></li></ul></li> <li class="expanded dropdown"><a href="/services" id="menu-master-menu-116401" data-target="#">Services <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu short"><li class="first leaf"><a href="/services" id="menu-master-menu-121056">All Custom Services</a></li> <li class="leaf"><a href="/services/protein-services" id="menu-master-menu-120591">Custom Protein Services</a></li> <li class="leaf"><a href="/services/luminex-assays-custom-development-services" id="menu-master-menu-122756">Luminex Custom Services</a></li> <li class="leaf"><a href="/services/custom-antibody-services" id="menu-master-menu-120551">Custom Antibody Services</a></li> <li class="leaf"><a href="/services/assay-production-custom-development-services" id="menu-master-menu-116866">Assay Custom Services</a></li> <li class="leaf"><a href="/services/custom-services-cell-gene-therapies" id="menu-master-menu-121151">Custom Services for Cell & Gene Therapies</a></li> <li class="leaf"><a href="/services/genome-engineering" id="menu-master-menu-122691">Genome Engineering Services</a></li> <li class="leaf"><a href="/services/bioactivity-testing-services" id="menu-master-menu-116911">Bioactivity Testing Services</a></li> <li class="leaf"><a href="/services/custom-chemistry" id="menu-master-menu-116901">Chemistry Services</a></li> <li class="leaf"><a href="/services/bulk-quote-request" id="menu-master-menu-116916">Bulk/Custom Formulation</a></li> <li class="leaf"><a href="/services/custom-cdna-cloning" id="menu-master-menu-116926">Custom cDNA Cloning</a></li> <li class="leaf menu-background one-column menu_services_image"><div class="menu_image_mask"><img loading="lazy" src="https://resources.rndsystems.com/images/navigation/services12-15.jpg" alt="Expedite Your Research" /></div><h4>Expedite Your Research</h4><a href="/services" class="btn">Expedite Your Research</a></li><li class="last leaf"><a href="/services/gmp-antibody-services" id="menu-master-menu-122711">Good Manufacturing Practice (GMP) Antibody Services</a></li> </ul></li> <li class="expanded dropdown"><a href="/pathways" id="menu-master-menu-116411" data-target="#">Pathways <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu short"><li class="first leaf"><a href="/pathways/cancer" id="menu-master-menu-116556">Cancer</a></li> <li class="leaf"><a href="/pathways/cardiovascular-biology" id="menu-master-menu-116561">Cardiovascular Biology</a></li> <li class="leaf"><a href="/pathways/developmental-biology" id="menu-master-menu-116566">Development</a></li> <li class="leaf"><a href="/pathways/glycobiology" id="menu-master-menu-116571">Glycobiology</a></li> <li class="leaf"><a href="/pathways/immunology" id="menu-master-menu-116576">Immunology</a></li> <li class="leaf"><a href="/pathways/neuroscience" id="menu-master-menu-116581">Neuroscience</a></li> <li class="leaf"><a href="/pathways/proteases" id="menu-master-menu-116586">Proteases & Other Enzymes</a></li> <li class="leaf"><a href="/pathways/signal-transduction" id="menu-master-menu-116591">Signal Transduction</a></li> <li class="leaf"><a href="/pathways/stem-cells" id="menu-master-menu-116596">Stem Cell</a></li> <li class="leaf"><a href="/pathways/ubiquitin-related-modifiers-and-pathways" id="menu-master-menu-116601">Ubiquitin, Related Modifiers, & Pathways</a></li> <li class="leaf"><a href="/pathways" id="menu-master-menu-116606">View All Pathways</a></li> <li class="last leaf menu-background one-column menu_pathways_image"><div class="menu_image_mask"><img loading="lazy" src="https://resources.rndsystems.com/images/navigation/pathwaysXX.jpg" alt="Explore Our Interactive Pathways" /></div><h4>Award-Winning Interactive Pathways</h4><a href="/pathways" class="btn">Explore Our Interactive Pathways</a></li></ul></li> <li class="expanded dropdown"><a href="/resources" id="menu-master-menu-116416" data-target="#">Resources <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu short"><li class="first leaf"><a href="/research-area" id="menu-master-menu-117016">Research Areas</a></li> <li class="leaf"><a href="/resources/protocols-troubleshooting-guides" id="menu-master-menu-117026">Protocols/Troubleshooting Guides/Videos</a></li> <li class="leaf"><a href="/resources/technical-information" id="menu-master-menu-117036">Technical Information</a></li> <li class="leaf"><a href="/resources/articles" id="menu-master-menu-117046">Articles</a></li> <li class="leaf"><a href="/resources/faqs" id="menu-master-menu-117056">Help & FAQs</a></li> <li class="leaf"><a href="/resources/literature" id="menu-master-menu-117071">Literature</a></li> <li class="leaf"><a href="/literature-request" id="menu-master-menu-117081">Request Literature</a></li> <li class="leaf"><a href="/resources/calculators" id="menu-master-menu-117091">Calculators</a></li> <li class="leaf"><a href="/resources/posters" id="menu-master-menu-117096">Posters</a></li> <li class="leaf"><a href="/blog" id="menu-master-menu-117106">Blog</a></li> <li class="leaf"><a href="/promotions" id="menu-master-menu-117121">Promotions</a></li> <li class="leaf"><a href="/grants-scholarships/bio-techne-travel-grants" id="menu-master-menu-117126">Travel Grants</a></li> <li class="leaf menu-background one-column menu_resources_image"><div class="menu_image_mask"><img loading="lazy" src="https://resources.rndsystems.com/images/navigation/resources-2017.jpg" alt="Request Literature" /></div><h4>Posters, Brochures, Whitepapers & Reference Guides</h4><a href="/literature-request" class="btn">Request Literature</a></li><li class="leaf"><a href="/resources/cell-markers" id="menu-master-menu-120471">Cell Markers</a></li> <li class="last leaf"><a href="https://www.rndsystems.com/products/promotions/get-your-new-lab-and-running" id="menu-master-menu-121241">New Lab Program</a></li> </ul></li> <li class="expanded dropdown"><a href="/quality" id="menu-master-menu-116421" data-target="#">R&D Systems Quality <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu short"><li class="first leaf"><a href="/quality" title="" id="menu-master-menu-116936">Quality Philosophy</a></li> <li class="leaf"><a href="/quality/people" title="" id="menu-master-menu-116946">People</a></li> <li class="leaf"><a href="/quality/place" title="" id="menu-master-menu-116956">Place</a></li> <li class="leaf"><a href="/quality/performance" title="" id="menu-master-menu-116966">Performance</a></li> <li class="leaf"><a href="/quality/product-development" title="" id="menu-master-menu-116976">Product Development</a></li> <li class="leaf"><a href="/quality/customer-satisfaction" title="" id="menu-master-menu-116986">Customer Satisfaction</a></li> <li class="leaf"><a href="/quality/rnd-systems-quality-advantage" title="" id="menu-master-menu-117001">The R&D Systems Quality Advantage</a></li> <li class="leaf"><a href="/quality/documents-certifications-and-faqs" title="" id="menu-master-menu-117006">Documents, Certifications, & FAQs</a></li> <li class="last leaf menu-background one-column menu_quality_image"><div class="menu_image_mask"><img loading="lazy" src="https://resources.rndsystems.com/images/menu-backgrounds/scientists.jpg" alt="R&D Systems Quality" /></div><h4>Experts in Reagent Quality</h4><span class="btn nolink" tabindex="0">R&D Systems Quality</span></li></ul></li> <li class="expanded dropdown"><a href="/about-us" id="menu-master-menu-116436" data-target="#">About Us <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu short"><li class="first leaf"><a href="https://www.bio-techne.com/about/careers" id="menu-master-menu-116481">Careers</a></li> <li class="leaf"><a href="https://www.bio-techne.com/brands" target="_blank" id="menu-master-menu-116491">Bio-Techne Brands</a></li> <li class="leaf"><a href="https://investors.bio-techne.com/" target="_blank" id="menu-master-menu-116501">Investor Relations</a></li> <li class="last leaf menu-background one-column menu_about_image"><div class="menu_image_mask"><img loading="lazy" src="https://resources.rndsystems.com/images/navigation/aboutUsXX02.jpg" alt="Join Us" /></div><h4>Our People are Our Greatest Asset</h4><a href="/about-us/career-opportunities" class="btn">Join Us</a></li></ul></li> <li class="last leaf"><a href="/support/contact-us" id="menu-master-menu-116471">Contact Us</a></li> </ul> </section> </div> </nav> </div> </header> <div class="breadcrumbs_wrapper"> <div class="breadcrumbs_container"> <div class="breadcrumb"><a href="/">Home</a> <span class="breadcrumb_separator">/</span> <a href="/pathways">Interactive Pathways & Processes</a> <span class="breadcrumb_separator">/</span> Type I Interferon Signaling Pathways</div> </div> </div> <div class="main-container container"> <section> <a id="main-content"></a> <div class="row pw_content"> <div id="pw_menu" class="pw_left col-xs-12 col-sm-4 col-md-3"> <div class="mobile_facet_wrapper"> <div class="search_mobile_buttons"> <div class="pw_toggle btn btn-tertiary"> Back to Pathways </div> </div> <div class="pw_menu_block"> <div class="et-pathways-topics pathway_menu_items"> <div class="pathways-block"> <h5 class="pathways-title"> <a href="/pathways">Interactive Pathways & Processes</a></h5> <ul class="pathways-ul" data-count="10" id="menuPathways"> <li class="pathways-li "> <form id="pathways_cancer_pathways" action="/pathways/cancer" method="post"> <a href="/pathways/cancer" data-form="pathways_cancer_pathways" class="pathway_link"> <span class="icon-"> Cancer Pathways </span> </a> <input type="hidden" name="pw_parent" value="Cancer"> </form> </li> <li class="pathways-li "> <form id="pathways_cardiovascular_biology_pathways" action="/pathways/cardiovascular-biology" method="post"> <a href="/pathways/cardiovascular-biology" data-form="pathways_cardiovascular_biology_pathways" class="pathway_link"> <span class="icon-"> Cardiovascular Biology Pathways </span> </a> <input type="hidden" name="pw_parent" value="cardiovascular"> </form> </li> <li class="pathways-li "> <form id="pathways_development_pathways" action="/pathways/developmental-biology" method="post"> <a href="/pathways/developmental-biology" data-form="pathways_development_pathways" class="pathway_link"> <span class="icon-"> Development Pathways </span> </a> <input type="hidden" name="pw_parent" value="developmental-biology"> </form> </li> <li class="pathways-li "> <form id="pathways_glycobiology_pathways" action="/pathways/glycobiology" method="post"> <a href="/pathways/glycobiology" data-form="pathways_glycobiology_pathways" class="pathway_link"> <span class="icon-"> Glycobiology Pathways </span> </a> <input type="hidden" name="pw_parent" value="Glycobiology"> </form> </li> <li class="pathways-li active"> <form id="pathways_immunology_pathways" action="/pathways/immunology" method="post"> <a href="/pathways/immunology" data-form="pathways_immunology_pathways" class="pathway_link"> <span class="icon-"> Immunology Pathways </span> </a> <input type="hidden" name="pw_parent" value="Immunology"> </form> <ul> <form id="pathways_adipokines__insulin_signaling_pathways" action="/pathways/adipokines-insulin-signaling-pathways" method="post"> <li class=""> <a href="/pathways/adipokines-insulin-signaling-pathways" class="pathway_link" data-form="pathways_adipokines__insulin_signaling_pathways"> Adipokines & Insulin Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_apoptosis_signaling_pathway" action="/pathways/apoptosis-signaling-pathway" method="post"> <li class=""> <a href="/pathways/apoptosis-signaling-pathway" class="pathway_link" data-form="pathways_apoptosis_signaling_pathway"> Apoptosis Signaling Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_b_cell_development_pathways" action="/pathways/b-cell-development-pathways" method="post"> <li class=""> <a href="/pathways/b-cell-development-pathways" class="pathway_link" data-form="pathways_b_cell_development_pathways"> B Cell Development Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_blood_coagulation_signaling_pathways" action="/pathways/blood-coagulation-signaling-pathways" method="post"> <li class=""> <a href="/pathways/blood-coagulation-signaling-pathways" class="pathway_link" data-form="pathways_blood_coagulation_signaling_pathways"> Blood Coagulation Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_cardiotrophin-1_signaling_pathways" action="/pathways/cardiotrophin-signaling-pathways" method="post"> <li class=""> <a href="/pathways/cardiotrophin-signaling-pathways" class="pathway_link" data-form="pathways_cardiotrophin-1_signaling_pathways"> Cardiotrophin-1 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_cardiotrophin-like_cytokine_clc_signaling_pathways" action="/pathways/cardiotrophin-cytokine-clc-signaling-pathways" method="post"> <li class=""> <a href="/pathways/cardiotrophin-cytokine-clc-signaling-pathways" class="pathway_link" data-form="pathways_cardiotrophin-like_cytokine_clc_signaling_pathways"> Cardiotrophin-like Cytokine CLC Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_chemokine_signaling_pathways" action="/pathways/chemokine-signaling-pathways" method="post"> <li class=""> <a href="/pathways/chemokine-signaling-pathways" class="pathway_link" data-form="pathways_chemokine_signaling_pathways"> Chemokine Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_chemokine_superfamily_pathway__human_mouse_ligand-receptor_interactions" action="/pathways/chemokine-superfamily-pathway-human-mouse-lig-recept-interactions" method="post"> <li class=""> <a href="/pathways/chemokine-superfamily-pathway-human-mouse-lig-recept-interactions" class="pathway_link" data-form="pathways_chemokine_superfamily_pathway__human_mouse_ligand-receptor_interactions"> Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_cntf_signaling_pathways" action="/pathways/cntf-signaling-pathways" method="post"> <li class=""> <a href="/pathways/cntf-signaling-pathways" class="pathway_link" data-form="pathways_cntf_signaling_pathways"> CNTF Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_common_cytokine_receptor_gamma-chain_family_signaling_pathways" action="/pathways/common-cytokine-receptor-gamma-chain-family-signaling-pathways" method="post"> <li class=""> <a href="/pathways/common-cytokine-receptor-gamma-chain-family-signaling-pathways" class="pathway_link" data-form="pathways_common_cytokine_receptor_gamma-chain_family_signaling_pathways"> Common Cytokine Receptor Gamma-Chain Family Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_dendritic_cell_lineage_development_pathways" action="/pathways/dendritic-cell-lineage-development-pathways" method="post"> <li class=""> <a href="/pathways/dendritic-cell-lineage-development-pathways" class="pathway_link" data-form="pathways_dendritic_cell_lineage_development_pathways"> Dendritic Cell Lineage Development Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_fgf_family_signaling_pathways" action="/pathways/fgf-signaling-pathways" method="post"> <li class=""> <a href="/pathways/fgf-signaling-pathways" class="pathway_link" data-form="pathways_fgf_family_signaling_pathways"> FGF Family Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_iga-producing_b_cells_in_the_intestine" action="/pathways/iga-producing-b-cells-in-the-intestine" method="post"> <li class=""> <a href="/pathways/iga-producing-b-cells-in-the-intestine" class="pathway_link" data-form="pathways_iga-producing_b_cells_in_the_intestine"> IgA-Producing B Cells in the Intestine </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-1_family_signaling_pathways" action="/pathways/il-1-family-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-1-family-signaling-pathways" class="pathway_link" data-form="pathways_il-1_family_signaling_pathways"> IL-1 Family Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-10_cytokine_family_signaling_pathway" action="/pathways/il-10-cytokine-family-signaling-pathway" method="post"> <li class=""> <a href="/pathways/il-10-cytokine-family-signaling-pathway" class="pathway_link" data-form="pathways_il-10_cytokine_family_signaling_pathway"> IL-10 Cytokine Family Signaling Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-11_signaling_pathways" action="/pathways/il-11-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-11-signaling-pathways" class="pathway_link" data-form="pathways_il-11_signaling_pathways"> IL-11 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-12_family_signaling_pathways" action="/pathways/il-12-family-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-12-family-signaling-pathways" class="pathway_link" data-form="pathways_il-12_family_signaling_pathways"> IL-12 Family Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-15_signaling_pathways" action="/pathways/il15-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il15-signaling-pathways" class="pathway_link" data-form="pathways_il-15_signaling_pathways"> IL-15 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-15_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-15-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-15-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-15_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-17_family_signaling_pathways" action="/pathways/il17-family-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il17-family-signaling-pathways" class="pathway_link" data-form="pathways_il-17_family_signaling_pathways"> IL-17 Family Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-2_signaling_pathways" action="/pathways/il2-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il2-signaling-pathways" class="pathway_link" data-form="pathways_il-2_signaling_pathways"> IL-2 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-2_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-2-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-2-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-2_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-2 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-21_signaling_pathways" action="/pathways/il21-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il21-signaling-pathways" class="pathway_link" data-form="pathways_il-21_signaling_pathways"> IL-21 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-21_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-21-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-21-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-21_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-27_p28_il-30_signaling_pathways" action="/pathways/il-27-p28il-30-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-27-p28il-30-signaling-pathways" class="pathway_link" data-form="pathways_il-27_p28_il-30_signaling_pathways"> IL-27 p28/IL-30 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-31_signaling_pathways" action="/pathways/il-31-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-31-signaling-pathways" class="pathway_link" data-form="pathways_il-31_signaling_pathways"> IL-31 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-4_signaling_pathways" action="/pathways/il4-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il4-signaling-pathways" class="pathway_link" data-form="pathways_il-4_signaling_pathways"> IL-4 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-4_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-4-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-4-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-4_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-6_signaling_pathways" action="/pathways/il-6-family-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-6-family-signaling-pathways" class="pathway_link" data-form="pathways_il-6_signaling_pathways"> IL-6 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-7_signaling_pathways" action="/pathways/il7-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il7-signaling-pathways" class="pathway_link" data-form="pathways_il-7_signaling_pathways"> IL-7 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-7_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-7-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-7-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-7_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-7 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-9_signaling_pathways" action="/pathways/il9-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il9-signaling-pathways" class="pathway_link" data-form="pathways_il-9_signaling_pathways"> IL-9 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-9_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-9-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-9-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-9_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_inflammasome_activation_pathways" action="/pathways/inflammasome-activation-pathways" method="post"> <li class=""> <a href="/pathways/inflammasome-activation-pathways" class="pathway_link" data-form="pathways_inflammasome_activation_pathways"> Inflammasome Activation Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_innate_lymphoid_cell_differentiation_pathways" action="/pathways/innate-lymphoid-cell-differentiation-pathways" method="post"> <li class=""> <a href="/pathways/innate-lymphoid-cell-differentiation-pathways" class="pathway_link" data-form="pathways_innate_lymphoid_cell_differentiation_pathways"> Innate Lymphoid Cell Differentiation Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_lif_signaling_pathways" action="/pathways/lif-signaling-pathways" method="post"> <li class=""> <a href="/pathways/lif-signaling-pathways" class="pathway_link" data-form="pathways_lif_signaling_pathways"> LIF Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mdsc-mediated_mechanisms_of_immunosuppression" action="/pathways/mdsc-mediated-mechanisms-of-immunosuppression" method="post"> <li class=""> <a href="/pathways/mdsc-mediated-mechanisms-of-immunosuppression" class="pathway_link" data-form="pathways_mdsc-mediated_mechanisms_of_immunosuppression"> MDSC-Mediated Mechanisms of Immunosuppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mechanisms_of_regulatory_t_cell-mediated_suppression" action="/pathways/mechanisms-of-regulatory-t-cell-mediated-suppression" method="post"> <li class=""> <a href="/pathways/mechanisms-of-regulatory-t-cell-mediated-suppression" class="pathway_link" data-form="pathways_mechanisms_of_regulatory_t_cell-mediated_suppression"> Mechanisms of Regulatory T Cell-Mediated Suppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mechanisms_of_tumor-associated_macrophage_tam-mediated_immunosuppression" action="/pathways/tumor-associated-macrophage-tam" method="post"> <li class=""> <a href="/pathways/tumor-associated-macrophage-tam" class="pathway_link" data-form="pathways_mechanisms_of_tumor-associated_macrophage_tam-mediated_immunosuppression"> Mechanisms of Tumor-Associated Macrophage TAM-Mediated Immunosuppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mechanisms_of_tumor-derived_exosome_tex-mediated_immunosuppression" action="/pathways/mechanisms-tumor-derived-exosome-tex-mediated-immunosuppression" method="post"> <li class=""> <a href="/pathways/mechanisms-tumor-derived-exosome-tex-mediated-immunosuppression" class="pathway_link" data-form="pathways_mechanisms_of_tumor-derived_exosome_tex-mediated_immunosuppression"> Mechanisms of Tumor-derived Exosome TEX-mediated Immunosuppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_natural_killer_cell_receptors__human_target_cell_–_nk_cell_ligand-receptor_interactions" action="/pathways/natural-killer-cell-receptors-human-target-cell-nk-cell-ligand-receptor-interactions-pathway" method="post"> <li class=""> <a href="/pathways/natural-killer-cell-receptors-human-target-cell-nk-cell-ligand-receptor-interactions-pathway" class="pathway_link" data-form="pathways_natural_killer_cell_receptors__human_target_cell_–_nk_cell_ligand-receptor_interactions"> Natural Killer Cell Receptors: Human Target Cell – NK Cell Ligand-Receptor Interactions </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_neuropoietin_signaling_pathways" action="/pathways/neuropoietin-signaling-pathways" method="post"> <li class=""> <a href="/pathways/neuropoietin-signaling-pathways" class="pathway_link" data-form="pathways_neuropoietin_signaling_pathways"> Neuropoietin Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_nod-like_receptor_signaling_pathways" action="/pathways/nod-like-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/nod-like-receptor-signaling-pathways" class="pathway_link" data-form="pathways_nod-like_receptor_signaling_pathways"> NOD-like Receptor Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_oncostatin_m_signaling_pathways" action="/pathways/oncostatin-m-signaling-pathways" method="post"> <li class=""> <a href="/pathways/oncostatin-m-signaling-pathways" class="pathway_link" data-form="pathways_oncostatin_m_signaling_pathways"> Oncostatin M Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_pathogen_or_damage-activated_c-type_lectin_receptor_signaling_pathways" action="/pathways/pathogen-damage-activated-c-type-lectin-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/pathogen-damage-activated-c-type-lectin-receptor-signaling-pathways" class="pathway_link" data-form="pathways_pathogen_or_damage-activated_c-type_lectin_receptor_signaling_pathways"> Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_t_cell_co-signaling_pathway__ligand-receptor_interactions" action="/pathways/t-cell-co-signaling-pathway-lig-recept-interactions" method="post"> <li class=""> <a href="/pathways/t-cell-co-signaling-pathway-lig-recept-interactions" class="pathway_link" data-form="pathways_t_cell_co-signaling_pathway__ligand-receptor_interactions"> T Cell Co-Signaling Pathway: Ligand-Receptor Interactions </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_tgf-beta_signaling_pathways" action="/pathways/tgf-beta-signaling-pathways" method="post"> <li class=""> <a href="/pathways/tgf-beta-signaling-pathways" class="pathway_link" data-form="pathways_tgf-beta_signaling_pathways"> TGF-beta Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_th1_differentiation_pathway" action="/pathways/th1-differentiation-pathway" method="post"> <li class=""> <a href="/pathways/th1-differentiation-pathway" class="pathway_link" data-form="pathways_th1_differentiation_pathway"> Th1 Differentiation Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_th17_differentiation_pathway" action="/pathways/th17-differentiation-pathway" method="post"> <li class=""> <a href="/pathways/th17-differentiation-pathway" class="pathway_link" data-form="pathways_th17_differentiation_pathway"> Th17 Differentiation Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_th2_differentiation_pathway" action="/pathways/th2-differentiation-pathway" method="post"> <li class=""> <a href="/pathways/th2-differentiation-pathway" class="pathway_link" data-form="pathways_th2_differentiation_pathway"> Th2 Differentiation Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_tnf_superfamily_pathway__human_ligand-receptor_interactions__their_associated_functions" action="/pathways/tnf-superfamily-pathway-human-lig-recept-interactions-their-associated-functions" method="post"> <li class=""> <a href="/pathways/tnf-superfamily-pathway-human-lig-recept-interactions-their-associated-functions" class="pathway_link" data-form="pathways_tnf_superfamily_pathway__human_ligand-receptor_interactions__their_associated_functions"> TNF Superfamily Pathway: Human Ligand-Receptor Interactions & their Associated Functions </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_toll-like_receptor_signaling_pathways" action="/pathways/toll-like-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/toll-like-receptor-signaling-pathways" class="pathway_link" data-form="pathways_toll-like_receptor_signaling_pathways"> Toll-Like Receptor Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_type_i_interferon_signaling_pathways" action="/pathways/type-i-interferon-signaling-pathways" method="post"> <li class="active"> <a href="/pathways/type-i-interferon-signaling-pathways" class="pathway_link" data-form="pathways_type_i_interferon_signaling_pathways"> Type I Interferon Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_type_ii_interferon_signaling_pathways" action="/pathways/type-ii-interferon-signaling-pathways" method="post"> <li class=""> <a href="/pathways/type-ii-interferon-signaling-pathways" class="pathway_link" data-form="pathways_type_ii_interferon_signaling_pathways"> Type II Interferon Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_type_iii_interferon_signaling_pathways" action="/pathways/type-iii-interferon-signaling-pathways" method="post"> <li class=""> <a href="/pathways/type-iii-interferon-signaling-pathways" class="pathway_link" data-form="pathways_type_iii_interferon_signaling_pathways"> Type III Interferon Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_vegf_-_vegf_r2_signaling_pathways" action="/pathways/vegf-vegf-r2-signaling-pathways" method="post"> <li class=""> <a href="/pathways/vegf-vegf-r2-signaling-pathways" class="pathway_link" data-form="pathways_vegf_-_vegf_r2_signaling_pathways"> VEGF - VEGF R2 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_virus_detection_and_induction_of_antiviral_signaling_pathways_by_rig-i-like_receptors_rlr" action="/pathways/rig-i-like-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/rig-i-like-receptor-signaling-pathways" class="pathway_link" data-form="pathways_virus_detection_and_induction_of_antiviral_signaling_pathways_by_rig-i-like_receptors_rlr"> Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors RLR </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> </ul> </li> <li class="pathways-li "> <form id="pathways_neuroscience_pathways" action="/pathways/neuroscience" method="post"> <a href="/pathways/neuroscience" data-form="pathways_neuroscience_pathways" class="pathway_link"> <span class="icon-"> Neuroscience Pathways </span> </a> <input type="hidden" name="pw_parent" value="Neuroscience"> </form> </li> <li class="pathways-li "> <form id="pathways_proteases__other_enzymes_pathways" action="/pathways/proteases" method="post"> <a href="/pathways/proteases" data-form="pathways_proteases__other_enzymes_pathways" class="pathway_link"> <span class="icon-"> Proteases & Other Enzymes Pathways </span> </a> <input type="hidden" name="pw_parent" value="proteases"> </form> </li> <li class="pathways-li "> <form id="pathways_signal_transduction_pathways" action="/pathways/signal-transduction" method="post"> <a href="/pathways/signal-transduction" data-form="pathways_signal_transduction_pathways" class="pathway_link"> <span class="icon-"> Signal Transduction Pathways </span> </a> <input type="hidden" name="pw_parent" value="signal-transduction"> </form> </li> <li class="pathways-li "> <form id="pathways_stem_cell_pathways" action="/pathways/stem-cells" method="post"> <a href="/pathways/stem-cells" data-form="pathways_stem_cell_pathways" class="pathway_link"> <span class="icon-"> Stem Cell Pathways </span> </a> <input type="hidden" name="pw_parent" value="stem-cells"> </form> </li> <li class="pathways-li "> <form id="pathways_ubiquitin_related_modifiers__pathways" action="/pathways/ubiquitin-related-modifiers-and-pathways" method="post"> <a href="/pathways/ubiquitin-related-modifiers-and-pathways" data-form="pathways_ubiquitin_related_modifiers__pathways" class="pathway_link"> <span class="icon-"> Ubiquitin, Related Modifiers, & Pathways </span> </a> <input type="hidden" name="pw_parent" value="ubiquitin-related-modifiers-and-pathways"> </form> </li> </ul> </div> </div> </div> </div> </div> <div class="pw_right col-xs-12 col-sm-8 col-md-9"> <div class="search_mobile_buttons"> <div class="pw_menu_toggle btn btn-tertiary">Show Categories</div> </div> <div class="pw_header"> <h1>Type I Interferon Signaling Pathways</h1> <p id="pw-intro-txt">Click on the links shown in the Explore Pathways box below to see the signaling pathways that are activated by members of either the type II or type III interferon families.<br></p> <div id="pw-con" data-mapname="" data-primary_segment=""> <div id="pw-main-nav-wrapper"> <div class="row"> <div id="pw-button-nav-top" class="col-xs-12 col-sm-12"> <div class="row"> <div id="pw-button-nav"> <div class="dropdown col-xs-12 col-sm-6 col-md-4"> <button class="btn-pw" type="button" data-toggle="dropup">Explore Pathways<span class="caret"></span></button> <ul id="pathwaynav" class="dropdown-content"><li class="pw_sm_btn-active"><a href="/pathways/type-i-interferon-signaling-pathways"><span>Type I Interferons</span></a></li> <li class="pw_rdblue_sm pw_sm_btn"><a href="/pathways/type-ii-interferon-signaling-pathways"><span>Type II Interferons</span></a></li> <li class="pw_rdblue_sm pw_sm_btn"><a href="/pathways/type-iii-interferon-signaling-pathways"><span>Type III Interferons</span></a></li> </ul> </div> </div> <div class="col-xs-12 col-sm-6 col-md-5" > <div id="pw-nav-subtitle"> Type I Interferon Signaling Pathways </div> </div> <div id="pw-print-button-col" class="col-xs-12 col-sm-6 col-md-3" > <a href="#print-copy-form" id="btn-get-print-copy" class="btn btn-primary"><img class="btn-icon" src="https://resources.rndsystems.com/images/Pathways/icons/icon-image.svg"/> Get Print Copy</a> </div> </div> </div> </div> </div> <div id="pw-map"> <div id="pw-maps"> <div id="el1_gry" class="type_i_ifn_signaling pw-sprite el-gray1 pw-gray" style="top:31px;left:349px;"> </div> <div id="el1_off" data-id="1" data-set="TypeIIFN1" data-type="" class="type_i_ifn_signaling pw-sprite el-off1" style="top:31px;left:349px;"> </div> <div id="el1_ct" class="pw-tooltip" data-id="1"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-alpha">IFN-alpha</a><br> <a target="_blank" href="/target/ifn-alpha 1">IFN-alpha 1</a><br> <a target="_blank" href="/target/ifn-alpha 2">IFN-alpha 2</a><br> <a target="_blank" href="/target/ifn-alpha 4">IFN-alpha 4</a><br> <a target="_blank" href="/target/ifn-alpha 11">IFN-alpha 11</a><br> <a target="_blank" href="/target/ifn-alpha 13">IFN-alpha 13</a><br> <a target="_blank" href="/target/ifn-alpha A">IFN-alpha A</a><br> <a target="_blank" href="/target/ifn-alpha B2">IFN-alpha B2</a><br> <a target="_blank" href="/target/ifn-alpha C">IFN-alpha C</a><br> <a target="_blank" href="/target/ifn-alpha D">IFN-alpha D</a><br> <a target="_blank" href="/target/ifn-alpha F">IFN-alpha F</a><br> <a target="_blank" href="/target/ifn-alpha G">IFN-alpha G </a><br> <a target="_blank" href="/target/ifn-alpha H2">IFN-alpha H2</a><br> <a target="_blank" href="/target/ifn-alpha I">IFN-alpha I</a><br> <a target="_blank" href="/target/ifn-alpha J1">IFN-alpha J1</a><br> <a target="_blank" href="/target/ifn-alpha K">IFN-alpha K</a><br> <a target="_blank" href="/target/ifn-alpha WA">IFN-alpha WA</a><br> <a target="_blank" href="/target/ifn-beta">IFN-beta</a><br> <a target="_blank" href="/target/ifn-epsilon">IFN-epsilon</a><br> <a target="_blank" href="/product_results.aspx?m=3660&k=">IFN-kappa</a><br> <a target="_blank" href="/target/ifn-omega">IFN-omega</a><br> <a target="_blank" href="/target/limitin-ifn-zeta">Limitin/IFN-zeta</a><br> </div> </div> <div id="el2_gry" class="type_i_ifn_signaling pw-label el-gray2 pw-gray" style="top:25px;left:382px;"> Type I IFN </div> <div id="el2_off" data-id="2" data-set="TypeIIFN1" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off2" style="top:25px;left:382px;"> Type I IFN</div> <div id="el2_ct" class="pw-tooltip" data-id="2"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-alpha">IFN-alpha</a><br> <a target="_blank" href="/target/ifn-alpha 1">IFN-alpha 1</a><br> <a target="_blank" href="/target/ifn-alpha 2">IFN-alpha 2</a><br> <a target="_blank" href="/target/ifn-alpha 4">IFN-alpha 4</a><br> <a target="_blank" href="/target/ifn-alpha 11">IFN-alpha 11</a><br> <a target="_blank" href="/target/ifn-alpha 13">IFN-alpha 13</a><br> <a target="_blank" href="/target/ifn-alpha A">IFN-alpha A</a><br> <a target="_blank" href="/target/ifn-alpha B2">IFN-alpha B2</a><br> <a target="_blank" href="/target/ifn-alpha C">IFN-alpha C</a><br> <a target="_blank" href="/target/ifn-alpha D">IFN-alpha D</a><br> <a target="_blank" href="/target/ifn-alpha F">IFN-alpha F</a><br> <a target="_blank" href="/target/ifn-alpha G">IFN-alpha G </a><br> <a target="_blank" href="/target/ifn-alpha H2">IFN-alpha H2</a><br> <a target="_blank" href="/target/ifn-alpha I">IFN-alpha I</a><br> <a target="_blank" href="/target/ifn-alpha J1">IFN-alpha J1</a><br> <a target="_blank" href="/target/ifn-alpha K">IFN-alpha K</a><br> <a target="_blank" href="/target/ifn-alpha WA">IFN-alpha WA</a><br> <a target="_blank" href="/target/ifn-beta">IFN-beta</a><br> <a target="_blank" href="/target/ifn-epsilon">IFN-epsilon</a><br> <a target="_blank" href="/product_results.aspx?m=3660&k=">IFN-kappa</a><br> <a target="_blank" href="/target/ifn-omega">IFN-omega</a><br> <a target="_blank" href="/target/limitin-ifn-zeta">Limitin/IFN-zeta</a><br> </div> </div> <div id="el3_gry" class="type_i_ifn_signaling pw-sprite el-gray3 pw-gray" style="top:-6px;left:328px;"> </div> <div id="el3_off" data-id="3" data-set="IFN-alphabetaR12" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off3" style="top:-6px;left:328px;"> </div> <div id="el3_ct" class="pw-tooltip" data-id="3"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-alpha-beta-r1">IFN-alpha/beta R1</a><br> </div> </div> <div id="el4_gry" class="type_i_ifn_signaling pw-label el-gray4 pw-gray" style="top:72px;left:230px;"> IFN-alpha/beta R1 </div> <div id="el4_off" data-id="4" data-set="IFN-alphabetaR12" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off4" style="top:72px;left:230px;"> IFN-alpha/beta R1</div> <div id="el4_ct" class="pw-tooltip" data-id="4"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-alpha-beta-r1">IFN-alpha/beta R1</a><br> </div> </div> <div id="el5_gry" class="type_i_ifn_signaling pw-sprite el-gray5 pw-gray" style="top:37px;left:369px;"> </div> <div id="el5_off" data-id="5" data-set="IFN-alphabetaR23" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off5" style="top:37px;left:369px;"> </div> <div id="el5_ct" class="pw-tooltip" data-id="5"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-alpha-beta-r2">IFN-alpha/beta R2</a><br> </div> </div> <div id="el6_gry" class="type_i_ifn_signaling pw-label el-gray6 pw-gray" style="top:72px;left:411px;"> IFN-alpha/beta R2 </div> <div id="el6_off" data-id="6" data-set="IFN-alphabetaR23" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off6" style="top:72px;left:411px;"> IFN-alpha/beta R2</div> <div id="el6_ct" class="pw-tooltip" data-id="6"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ifn-alpha-beta-r2">IFN-alpha/beta R2</a><br> </div> </div> <div id="el7_gry" class="type_i_ifn_signaling pw-sprite el-gray7 pw-gray" style="top:149px;left:318px;"> </div> <div id="el7_off" data-id="7" data-set="Tyk24" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off7" style="top:149px;left:318px;"> </div> <div id="el7_ct" class="pw-tooltip" data-id="7"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/tyk2">Tyk2</a><br> </div> </div> <div id="el8_gry" class="type_i_ifn_signaling pw-label el-gray8 pw-gray" style="top:162px;left:292px;"> Tyk2 </div> <div id="el8_off" data-id="8" data-set="Tyk24" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off8" style="top:162px;left:292px;"> Tyk2</div> <div id="el8_ct" class="pw-tooltip" data-id="8"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/tyk2">Tyk2</a><br> </div> </div> <div id="el9_gry" class="type_i_ifn_signaling pw-sprite el-gray9 pw-gray" style="top:149px;left:391px;"> </div> <div id="el9_off" data-id="9" data-set="Jak15" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off9" style="top:149px;left:391px;"> </div> <div id="el9_ct" class="pw-tooltip" data-id="9"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak1">Jak1</a><br> </div> </div> <div id="el10_gry" class="type_i_ifn_signaling pw-label el-gray10 pw-gray" style="top:155px;left:426px;"> Jak1 </div> <div id="el10_off" data-id="10" data-set="Jak15" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off10" style="top:155px;left:426px;"> Jak1</div> <div id="el10_ct" class="pw-tooltip" data-id="10"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/jak1">Jak1</a><br> </div> </div> <div id="el11_gry" class="type_i_ifn_signaling pw-sprite el-gray11 pw-gray" style="top:237px;left:173px;"> </div> <div id="el11_off" data-id="11" data-set="IRS126" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off11" style="top:237px;left:173px;"> </div> <div id="el11_ct" class="pw-tooltip" data-id="11"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/irs1">IRS1</a><br><a target="_blank" href="/target/irs2">IRS2</a><br> </div> </div> <div id="el12_gry" class="type_i_ifn_signaling pw-label el-gray12 pw-gray" style="top:245px;left:136px;"> IRS1/2 </div> <div id="el12_off" data-id="12" data-set="IRS126" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off12" style="top:245px;left:136px;"> IRS1/2</div> <div id="el12_ct" class="pw-tooltip" data-id="12"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/irs1">IRS1</a><br><a target="_blank" href="/target/irs2">IRS2</a><br> </div> </div> <div id="el13_gry" class="type_i_ifn_signaling pw-sprite el-gray13 pw-gray" style="top:258px;left:173px;"> </div> <div id="el13_off" data-id="13" data-set="PI3-K7" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off13" style="top:258px;left:173px;"> </div> <div id="el13_ct" class="pw-tooltip" data-id="13"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/pi-3-kinase-p85-alpha">PI 3-Kinase p85 alpha</a><br><a target="_blank" href="/target/pi-3-kinase-p110-beta">PI 3-Kinase p110 beta</a><br><a target="_blank" href="/target/pi-3-kinase-p110-gamma">PI 3-Kinase p110 gamma</a><br><a target="_blank" href="/target/pi-3-kinase-p110-delta">PI 3-Kinase p110 delta</a><br><a target="_blank" href="/target/pi-3-kinase-p85-beta">PI 3-Kinase p85 beta</a><br><a target="_blank" href="/search?keywords=pi3k">All PI 3-K Products</a><br> </div> </div> <div id="el14_gry" class="type_i_ifn_signaling pw-label el-gray14 pw-gray" style="top:271px;left:139px;"> PI 3-K </div> <div id="el14_off" data-id="14" data-set="PI3-K7" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off14" style="top:271px;left:139px;"> PI 3-K</div> <div id="el14_ct" class="pw-tooltip" data-id="14"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/pi-3-kinase-p85-alpha">PI 3-Kinase p85 alpha</a><br><a target="_blank" href="/target/pi-3-kinase-p110-beta">PI 3-Kinase p110 beta</a><br><a target="_blank" href="/target/pi-3-kinase-p110-gamma">PI 3-Kinase p110 gamma</a><br><a target="_blank" href="/target/pi-3-kinase-p110-delta">PI 3-Kinase p110 delta</a><br><a target="_blank" href="/target/pi-3-kinase-p85-beta">PI 3-Kinase p85 beta</a><br><a target="_blank" href="/search?keywords=pi3k">All PI 3-K Products</a><br> </div> </div> <div id="el15_gry" class="type_i_ifn_signaling pw-sprite el-gray15 pw-gray" style="top:310px;left:175px;"> </div> <div id="el15_off" data-id="15" data-set="Akt8" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off15" style="top:310px;left:175px;"> </div> <div id="el15_ct" class="pw-tooltip" data-id="15"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/akt">Akt</a><br><a target="_blank" href="/target/akt1">Akt1</a><br><a target="_blank" href="/target/akt2">Akt2</a><br><a target="_blank" href="/target/akt3">Akt3</a><br> </div> </div> <div id="el16_gry" class="type_i_ifn_signaling pw-label el-gray16 pw-gray" style="top:319px;left:183px;"> Akt </div> <div id="el16_off" data-id="16" data-set="Akt8" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off16" style="top:319px;left:183px;"> Akt</div> <div id="el16_ct" class="pw-tooltip" data-id="16"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/akt">Akt</a><br><a target="_blank" href="/target/akt1">Akt1</a><br><a target="_blank" href="/target/akt2">Akt2</a><br><a target="_blank" href="/target/akt3">Akt3</a><br> </div> </div> <div id="el17_gry" class="type_i_ifn_signaling pw-sprite el-gray17 pw-gray" style="top:361px;left:137px;"> </div> <div id="el17_off" data-id="17" data-set="IKK-beta9" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off17" style="top:361px;left:137px;"> </div> <div id="el17_ct" class="pw-tooltip" data-id="17"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ikk-beta">IKK beta</a><br> </div> </div> <div id="el18_gry" class="type_i_ifn_signaling pw-label el-gray18 pw-gray" style="top:371px;left:122px;"> IKK-beta </div> <div id="el18_off" data-id="18" data-set="IKK-beta9" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off18" style="top:371px;left:122px;"> IKK-beta</div> <div id="el18_ct" class="pw-tooltip" data-id="18"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ikk-beta">IKK beta</a><br> </div> </div> <div id="el19_gry" class="type_i_ifn_signaling pw-sprite el-gray19 pw-gray" style="top:333px;left:42px;"> </div> <div id="el19_off" data-id="19" data-set="Proteasome13" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off19" style="top:333px;left:42px;"> </div> <div id="el19_ct" class="pw-tooltip" data-id="19"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/26s-proteasome">26S Proteasome</a><br><a target="_blank" href="/target/19s-proteasome">19S Proteasome</a><br><a target="_blank" href="/target/20s-proteasome">20S Proteasome</a><br><a target="_blank" href="/target/proteasome-inhibitors">proteasome inhibitors</a><br><a target="_blank" href="/target/proteasome-substrates">proteasome substrates</a><br> </div> </div> <div id="el20_gry" class="type_i_ifn_signaling pw-label el-gray20 pw-gray" style="top:346px;left:97px;"> I kappa B </div> <div id="el20_off" data-id="20" data-set="IkappaB10" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off20" style="top:346px;left:97px;"> I kappa B</div> <div id="el20_ct" class="pw-tooltip" data-id="20"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ikb-alpha">IkB-alpha</a><br><a target="_blank" href="/target/ikb-beta">IkB-beta</a><br><a target="_blank" href="/target/ikb-epsilon">IkB-epsilon</a><br><a target="_blank" href="/target/nfkb-ikb-inhibitors">NFkB/IkB Inhibitors</a><br><a target="_blank" href="/target/nfkb-ikb-activators">NFkB/IkB Activators</a><br> </div> </div> <div id="el21_gry" class="type_i_ifn_signaling pw-sprite el-gray21 pw-gray" style="top:402px;left:19px;"> </div> <div id="el21_off" data-id="21" data-set="NF-kappaB11" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off21" style="top:402px;left:19px;"> </div> <div id="el21_ct" class="pw-tooltip" data-id="21"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/nfkb1">NFkB1</a><br><a target="_blank" href="/target/nfkb2">NFkB2</a><br><a target="_blank" href="/target/rela-nfkb-p65">RelA/NFkB p65</a><br><a target="_blank" href="/target/relb">RelB</a><br><a target="_blank" href="/target/c-rel">c-Rel</a><br><a target="_blank" href="/target/nfkb-ikb-inhibitors">NFkB/IkB Inhibitors</a><br><a target="_blank" href="/target/nfkb-ikb-activators">NFkB/IkB Activators</a><br> </div> </div> <div id="el22_gry" class="type_i_ifn_signaling pw-label el-gray22 pw-gray" style="top:417px;left:15px;"> NF-kappa B </div> <div id="el22_off" data-id="22" data-set="NF-kappaB11" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off22" style="top:417px;left:15px;"> NF-kappa B</div> <div id="el22_ct" class="pw-tooltip" data-id="22"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/nfkb1">NFkB1</a><br><a target="_blank" href="/target/nfkb2">NFkB2</a><br><a target="_blank" href="/target/rela-nfkb-p65">RelA/NFkB p65</a><br><a target="_blank" href="/target/relb">RelB</a><br><a target="_blank" href="/target/c-rel">c-Rel</a><br><a target="_blank" href="/target/nfkb-ikb-inhibitors">NFkB/IkB Inhibitors</a><br><a target="_blank" href="/target/nfkb-ikb-activators">NFkB/IkB Activators</a><br> </div> </div> <div id="el23_gry" class="type_i_ifn_signaling pw-sprite el-gray23 pw-gray" style="top:392px;left:36px;"> </div> <div id="el23_off" data-id="23" data-set="IkappaB12" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off23" style="top:392px;left:36px;"> </div> <div id="el23_ct" class="pw-tooltip" data-id="23"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ikb-alpha">IkB-alpha</a><br><a target="_blank" href="/target/ikb-beta">IkB-beta</a><br><a target="_blank" href="/target/ikb-epsilon">IkB-epsilon</a><br><a target="_blank" href="/target/nfkb-ikb-inhibitors">NFkB/IkB Inhibitors</a><br><a target="_blank" href="/target/nfkb-ikb-activators">NFkB/IkB Activators</a><br> </div> </div> <div id="el24_gry" class="type_i_ifn_signaling pw-label el-gray24 pw-gray" style="top:400px;left:2px;"> I kappa B </div> <div id="el24_off" data-id="24" data-set="IkappaB12" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off24" style="top:400px;left:2px;"> I kappa B</div> <div id="el24_ct" class="pw-tooltip" data-id="24"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ikb-alpha">IkB-alpha</a><br><a target="_blank" href="/target/ikb-beta">IkB-beta</a><br><a target="_blank" href="/target/ikb-epsilon">IkB-epsilon</a><br><a target="_blank" href="/target/nfkb-ikb-inhibitors">NFkB/IkB Inhibitors</a><br><a target="_blank" href="/target/nfkb-ikb-activators">NFkB/IkB Activators</a><br> </div> </div> <div id="el25_gry" class="type_i_ifn_signaling pw-sprite el-gray25 pw-gray" style="top:337px;left:68px;"> </div> <div id="el25_off" data-id="25" data-set="IkappaB10" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off25" style="top:337px;left:68px;"> </div> <div id="el25_ct" class="pw-tooltip" data-id="25"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ikb-alpha">IkB-alpha</a><br><a target="_blank" href="/target/ikb-beta">IkB-beta</a><br><a target="_blank" href="/target/ikb-epsilon">IkB-epsilon</a><br><a target="_blank" href="/target/nfkb-ikb-inhibitors">NFkB/IkB Inhibitors</a><br><a target="_blank" href="/target/nfkb-ikb-activators">NFkB/IkB Activators</a><br> </div> </div> <div id="el26_gry" class="type_i_ifn_signaling pw-label el-gray26 pw-gray" style="top:322px;left:20px;"> Proteasome </div> <div id="el26_off" data-id="26" data-set="Proteasome13" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off26" style="top:322px;left:20px;"> Proteasome</div> <div id="el26_ct" class="pw-tooltip" data-id="26"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/26s-proteasome">26S Proteasome</a><br><a target="_blank" href="/target/19s-proteasome">19S Proteasome</a><br><a target="_blank" href="/target/20s-proteasome">20S Proteasome</a><br><a target="_blank" href="/target/proteasome-inhibitors">proteasome inhibitors</a><br><a target="_blank" href="/target/proteasome-substrates">proteasome substrates</a><br> </div> </div> <div id="el27_gry" class="type_i_ifn_signaling pw-sprite el-gray27 pw-gray" style="top:794px;left:59px;"> </div> <div id="el27_off" data-id="27" data-set="NF-kappaB14" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off27" style="top:794px;left:59px;"> </div> <div id="el27_ct" class="pw-tooltip" data-id="27"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/nfkb1">NFkB1</a><br><a target="_blank" href="/target/nfkb2">NFkB2</a><br><a target="_blank" href="/target/rela-nfkb-p65">RelA/NFkB p65</a><br><a target="_blank" href="/target/relb">RelB</a><br><a target="_blank" href="/target/c-rel">c-Rel</a><br><a target="_blank" href="/target/nfkb-ikb-inhibitors">NFkB/IkB Inhibitors</a><br><a target="_blank" href="/target/nfkb-ikb-activators">NFkB/IkB Activators</a><br> </div> </div> <div id="el28_gry" class="type_i_ifn_signaling pw-label el-gray28 pw-gray" style="top:788px;left:57px;"> NF-kappa B </div> <div id="el28_off" data-id="28" data-set="NF-kappaB14" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off28" style="top:788px;left:57px;"> NF-kappa B</div> <div id="el28_ct" class="pw-tooltip" data-id="28"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/nfkb1">NFkB1</a><br><a target="_blank" href="/target/nfkb2">NFkB2</a><br><a target="_blank" href="/target/rela-nfkb-p65">RelA/NFkB p65</a><br><a target="_blank" href="/target/relb">RelB</a><br><a target="_blank" href="/target/c-rel">c-Rel</a><br><a target="_blank" href="/target/nfkb-ikb-inhibitors">NFkB/IkB Inhibitors</a><br><a target="_blank" href="/target/nfkb-ikb-activators">NFkB/IkB Activators</a><br> </div> </div> <div id="el29_gry" class="type_i_ifn_signaling pw-sprite el-gray29 pw-gray" style="top:360px;left:196px;"> </div> <div id="el29_off" data-id="29" data-set="TSC1215" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off29" style="top:360px;left:196px;"> </div> <div id="el29_ct" class="pw-tooltip" data-id="29"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/tsc1">TSC1</a><br><a target="_blank" href="/target/tsc2">TSC2</a><br> </div> </div> <div id="el30_gry" class="type_i_ifn_signaling pw-label el-gray30 pw-gray" style="top:373px;left:208px;"> TSC1/2 </div> <div id="el30_off" data-id="30" data-set="TSC1215" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off30" style="top:373px;left:208px;"> TSC1/2</div> <div id="el30_ct" class="pw-tooltip" data-id="30"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/tsc1">TSC1</a><br><a target="_blank" href="/target/tsc2">TSC2</a><br> </div> </div> <div id="el31_gry" class="type_i_ifn_signaling pw-sprite el-gray31 pw-gray" style="top:411px;left:195px;"> </div> <div id="el31_off" data-id="31" data-set="mTOR16" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off31" style="top:411px;left:195px;"> </div> <div id="el31_ct" class="pw-tooltip" data-id="31"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/tor">TOR</a><br> </div> </div> <div id="el32_gry" class="type_i_ifn_signaling pw-label el-gray32 pw-gray" style="top:421px;left:197px;"> mTOR </div> <div id="el32_off" data-id="32" data-set="mTOR16" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off32" style="top:421px;left:197px;"> mTOR</div> <div id="el32_ct" class="pw-tooltip" data-id="32"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/tor">TOR</a><br> </div> </div> <div id="el33_gry" class="type_i_ifn_signaling pw-sprite el-gray33 pw-gray" style="top:463px;left:117px;"> </div> <div id="el33_off" data-id="33" data-set="FourEBP117" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off33" style="top:463px;left:117px;"> </div> <div id="el33_ct" class="pw-tooltip" data-id="33"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/4ebp1">4EBP1</a><br> </div> </div> <div id="el34_gry" class="type_i_ifn_signaling pw-label el-gray34 pw-gray" style="top:475px;left:82px;"> 4EBP1 </div> <div id="el34_off" data-id="34" data-set="FourEBP117" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off34" style="top:475px;left:82px;"> 4EBP1</div> <div id="el34_ct" class="pw-tooltip" data-id="34"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/4ebp1">4EBP1</a><br> </div> </div> <div id="el35_gry" class="type_i_ifn_signaling pw-sprite el-gray35 pw-gray" style="top:484px;left:117px;"> </div> <div id="el35_off" data-id="35" data-set="eIF4E18" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off35" style="top:484px;left:117px;"> </div> <div id="el35_ct" class="pw-tooltip" data-id="35"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/eif4e">eIF4E</a><br> </div> </div> <div id="el36_gry" class="type_i_ifn_signaling pw-label el-gray36 pw-gray" style="top:493px;left:84px;"> eIF4E </div> <div id="el36_off" data-id="36" data-set="eIF4E18" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off36" style="top:493px;left:84px;"> eIF4E</div> <div id="el36_ct" class="pw-tooltip" data-id="36"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/eif4e">eIF4E</a><br> </div> </div> <div id="el37_gry" class="type_i_ifn_signaling pw-sprite el-gray37 pw-gray" style="top:536px;left:93px;"> </div> <div id="el37_off" data-id="37" data-set="eIF4E19" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off37" style="top:536px;left:93px;"> </div> <div id="el37_ct" class="pw-tooltip" data-id="37"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/eif4e">eIF4E</a><br> </div> </div> <div id="el38_gry" class="type_i_ifn_signaling pw-label el-gray38 pw-gray" style="top:568px;left:91px;"> eIF4E </div> <div id="el38_off" data-id="38" data-set="eIF4E19" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off38" style="top:568px;left:91px;"> eIF4E</div> <div id="el38_ct" class="pw-tooltip" data-id="38"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/eif4e">eIF4E</a><br> </div> </div> <div id="el39_gry" class="type_i_ifn_signaling pw-sprite el-gray39 pw-gray" style="top:535px;left:142px;"> </div> <div id="el39_off" data-id="39" data-set="fourEBP120" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off39" style="top:535px;left:142px;"> </div> <div id="el39_ct" class="pw-tooltip" data-id="39"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/4ebp1">4EBP1</a><br> </div> </div> <div id="el40_gry" class="type_i_ifn_signaling pw-label el-gray40 pw-gray" style="top:568px;left:136px;"> 4EBP1 </div> <div id="el40_off" data-id="40" data-set="fourEBP120" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off40" style="top:568px;left:136px;"> 4EBP1</div> <div id="el40_ct" class="pw-tooltip" data-id="40"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/4ebp1">4EBP1</a><br> </div> </div> <div id="el41_gry" class="type_i_ifn_signaling pw-sprite el-gray41 pw-gray" style="top:465px;left:197px;"> </div> <div id="el41_off" data-id="41" data-set="p70S6Kinase21" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off41" style="top:465px;left:197px;"> </div> <div id="el41_ct" class="pw-tooltip" data-id="41"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/p70-s6-kinase">p70 S6 Kinase</a> </div> </div> <div id="el42_gry" class="type_i_ifn_signaling pw-label el-gray42 pw-gray" style="top:478px;left:193px;"> p70 S6 Kinase </div> <div id="el42_off" data-id="42" data-set="p70S6Kinase21" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off42" style="top:478px;left:193px;"> p70 S6 Kinase</div> <div id="el42_ct" class="pw-tooltip" data-id="42"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/p70-s6-kinase">p70 S6 Kinase</a> </div> </div> <div id="el43_gry" class="type_i_ifn_signaling pw-sprite el-gray43 pw-gray" style="top:514px;left:198px;"> </div> <div id="el43_off" data-id="43" data-set="RPS622" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off43" style="top:514px;left:198px;"> </div> <div id="el43_ct" class="pw-tooltip" data-id="43"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ribosomal-protein-s6-rps6">Ribosomal Protein S6</a><br> </div> </div> <div id="el44_gry" class="type_i_ifn_signaling pw-label el-gray44 pw-gray" style="top:530px;left:226px;"> RPS6 </div> <div id="el44_off" data-id="44" data-set="RPS622" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off44" style="top:530px;left:226px;"> RPS6</div> <div id="el44_ct" class="pw-tooltip" data-id="44"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/ribosomal-protein-s6-rps6">Ribosomal Protein S6</a><br> </div> </div> <div id="el45_gry" class="type_i_ifn_signaling pw-label2 el-gray45 pw-gray" style="top:619px;left:94px;"> mRNA Translation </div> <div id="el45_off" data-id="45" data-set="mRNATranslation" data-type="" class="type_i_ifn_signaling pw-label2 el-off45" style="top:619px;left:94px;"> mRNA Translation</div> <div id="el45_ct" class="pw-tooltip" data-id="45"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el46_gry" class="type_i_ifn_signaling pw-label2 el-gray46 pw-gray" style="top:644px;left:96px;"> <h2 class="pw_txtBox">Protein Synthesis</h2> </div> <div id="el46_off" data-id="46" data-set="ProteinSynthesis" data-type="" class="type_i_ifn_signaling pw-label2 el-off46" style="top:644px;left:96px;"> <h2 class="pw_txtBox">Protein Synthesis</h2></div> <div id="el46_ct" class="pw-tooltip" data-id="46"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el47_gry" class="type_i_ifn_signaling pw-label2 el-gray47 pw-gray" style="top:872px;left:59px;"> Survival Signals </div> <div id="el47_off" data-id="47" data-set="SurvivalSignals" data-type="" class="type_i_ifn_signaling pw-label2 el-off47" style="top:872px;left:59px;"> Survival Signals</div> <div id="el47_ct" class="pw-tooltip" data-id="47"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el48_gry" class="type_i_ifn_signaling pw-label2 pw-center el-gray48 pw-gray" style="top:889px;left:18px;"> Expression of Antigen<br>Processing/Presentation Signals </div> <div id="el48_off" data-id="48" data-set="ExpressionofAntigenProcessingPresentationSignals" data-type="" class="type_i_ifn_signaling pw-label2 pw-center el-off48" style="top:889px;left:18px;"> Expression of Antigen<br>Processing/Presentation Signals</div> <div id="el48_ct" class="pw-tooltip" data-id="48"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el49_gry" class="type_i_ifn_signaling pw-sprite el-gray49 pw-gray" style="top:292px;left:315px;"> </div> <div id="el49_off" data-id="49" data-set="Vav27" data-type="" class="type_i_ifn_signaling pw-sprite el-off49" style="top:292px;left:315px;"> </div> <div id="el49_ct" class="pw-tooltip" data-id="49"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/vav-1">Vav-1</a><br> </div> </div> <div id="el50_gry" class="type_i_ifn_signaling pw-label el-gray50 pw-gray" style="top:303px;left:324px;"> Vav </div> <div id="el50_off" data-id="50" data-set="Vav27" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off50" style="top:303px;left:324px;"> Vav</div> <div id="el50_ct" class="pw-tooltip" data-id="50"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/vav-1">Vav-1</a><br> </div> </div> <div id="el51_gry" class="type_i_ifn_signaling pw-sprite pw-sprite-inactive el-gray51 pw-gray" style="top:294px;left:400px;"> </div> <div id="el51_off" data-id="51" data-set="GEFs28" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite pw-sprite-inactive el-off51" style="top:294px;left:400px;"> </div> <div id="el51_ct" class="pw-tooltip" data-id="51"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el52_gry" class="type_i_ifn_signaling pw-label el-gray52 pw-gray" style="top:304px;left:399px;"> GEFs </div> <div id="el52_off" data-id="52" data-set="GEFs28" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off52" style="top:304px;left:399px;"> GEFs</div> <div id="el52_ct" class="pw-tooltip" data-id="52"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el53_gry" class="type_i_ifn_signaling pw-sprite el-gray53 pw-gray" style="top:362px;left:357px;"> </div> <div id="el53_off" data-id="53" data-set="Rac129" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off53" style="top:362px;left:357px;"> </div> <div id="el53_ct" class="pw-tooltip" data-id="53"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/rac1">Rac1</a><br> </div> </div> <div id="el54_gry" class="type_i_ifn_signaling pw-label el-gray54 pw-gray" style="top:371px;left:360px;"> Rac1 </div> <div id="el54_off" data-id="54" data-set="Rac129" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off54" style="top:371px;left:360px;"> Rac1</div> <div id="el54_ct" class="pw-tooltip" data-id="54"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/rac1">Rac1</a><br> </div> </div> <div id="el55_gry" class="type_i_ifn_signaling pw-sprite pw-sprite-inactive el-gray55 pw-gray" style="top:429px;left:322px;"> </div> <div id="el55_off" data-id="55" data-set="MAPKKK30" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite pw-sprite-inactive el-off55" style="top:429px;left:322px;"> </div> <div id="el55_ct" class="pw-tooltip" data-id="55"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el56_gry" class="type_i_ifn_signaling pw-label el-gray56 pw-gray" style="top:439px;left:315px;"> MAPKKK </div> <div id="el56_off" data-id="56" data-set="MAPKKK30" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off56" style="top:439px;left:315px;"> MAPKKK</div> <div id="el56_ct" class="pw-tooltip" data-id="56"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el57_gry" class="type_i_ifn_signaling pw-sprite el-gray57 pw-gray" style="top:481px;left:298px;"> </div> <div id="el57_off" data-id="57" data-set="MKK331" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off57" style="top:481px;left:298px;"> </div> <div id="el57_ct" class="pw-tooltip" data-id="57"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/mkk3">MKK3</a><br> </div> </div> <div id="el58_gry" class="type_i_ifn_signaling pw-label el-gray58 pw-gray" style="top:495px;left:294px;"> MKK3 </div> <div id="el58_off" data-id="58" data-set="MKK331" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off58" style="top:495px;left:294px;"> MKK3</div> <div id="el58_ct" class="pw-tooltip" data-id="58"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/mkk3">MKK3</a><br> </div> </div> <div id="el59_gry" class="type_i_ifn_signaling pw-sprite el-gray59 pw-gray" style="top:484px;left:349px;"> </div> <div id="el59_off" data-id="59" data-set="MKK632" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off59" style="top:484px;left:349px;"> </div> <div id="el59_ct" class="pw-tooltip" data-id="59"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/mkk6">MKK6</a><br> </div> </div> <div id="el60_gry" class="type_i_ifn_signaling pw-label el-gray60 pw-gray" style="top:495px;left:353px;"> MKK6 </div> <div id="el60_off" data-id="60" data-set="MKK632" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off60" style="top:495px;left:353px;"> MKK6</div> <div id="el60_ct" class="pw-tooltip" data-id="60"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/mkk6">MKK6</a><br> </div> </div> <div id="el61_gry" class="type_i_ifn_signaling pw-sprite el-gray61 pw-gray" style="top:538px;left:324px;"> </div> <div id="el61_off" data-id="61" data-set="p3833" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off61" style="top:538px;left:324px;"> </div> <div id="el61_ct" class="pw-tooltip" data-id="61"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/p38">p38</a><br><a target="_blank" href="/target/p38 alpha">p38 alpha</a><br><a target="_blank" href="/target/p38 beta">p38 beta</a><br><a target="_blank" href="/target/p38 gamma">p38 gamma</a><br><a target="_blank" href="/target/p38 delta">p38 delta</a><br><a target="_blank" href="/target/p38 Inhibitors">p38 Inhibitors</a><br> </div> </div> <div id="el62_gry" class="type_i_ifn_signaling pw-label el-gray62 pw-gray" style="top:550px;left:327px;"> p38 </div> <div id="el62_off" data-id="62" data-set="p3833" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off62" style="top:550px;left:327px;"> p38</div> <div id="el62_ct" class="pw-tooltip" data-id="62"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/p38">p38</a><br><a target="_blank" href="/target/p38 alpha">p38 alpha</a><br><a target="_blank" href="/target/p38 beta">p38 beta</a><br><a target="_blank" href="/target/p38 gamma">p38 gamma</a><br><a target="_blank" href="/target/p38 delta">p38 delta</a><br><a target="_blank" href="/target/p38 Inhibitors">p38 Inhibitors</a><br> </div> </div> <div id="el63_gry" class="type_i_ifn_signaling pw-sprite el-gray63 pw-gray" style="top:590px;left:280px;"> </div> <div id="el63_off" data-id="63" data-set="MNK1234" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off63" style="top:590px;left:280px;"> </div> <div id="el63_ct" class="pw-tooltip" data-id="63"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/mnk-inhibitors">MNK Inhibitors</a> </div> </div> <div id="el64_gry" class="type_i_ifn_signaling pw-label el-gray64 pw-gray" style="top:622px;left:273px;"> MNK1/2 </div> <div id="el64_off" data-id="64" data-set="MNK1234" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off64" style="top:622px;left:273px;"> MNK1/2</div> <div id="el64_ct" class="pw-tooltip" data-id="64"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/mnk-inhibitors">MNK Inhibitors</a> </div> </div> <div id="el65_gry" class="type_i_ifn_signaling pw-sprite el-gray65 pw-gray" style="top:590px;left:371px;"> </div> <div id="el65_off" data-id="65" data-set="MAPKAPK2335" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off65" style="top:590px;left:371px;"> </div> <div id="el65_ct" class="pw-tooltip" data-id="65"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/mapkapk2">MAPKAPK2</a> </div> </div> <div id="el66_gry" class="type_i_ifn_signaling pw-label el-gray66 pw-gray" style="top:621px;left:354px;"> MAPKAPK2/3 </div> <div id="el66_off" data-id="66" data-set="MAPKAPK2335" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off66" style="top:621px;left:354px;"> MAPKAPK2/3</div> <div id="el66_ct" class="pw-tooltip" data-id="66"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/mapkapk2">MAPKAPK2</a> </div> </div> <div id="el67_gry" class="type_i_ifn_signaling pw-sprite el-gray67 pw-gray" style="top:753px;left:280px;"> </div> <div id="el67_off" data-id="67" data-set="MSK1236" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off67" style="top:753px;left:280px;"> </div> <div id="el67_ct" class="pw-tooltip" data-id="67"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/msk1">MSK1</a><br><a target="_blank" href="/target/msk2">MSK2</a><br> </div> </div> <div id="el68_gry" class="type_i_ifn_signaling pw-label el-gray68 pw-gray" style="top:763px;left:273px;"> MSK1/2 </div> <div id="el68_off" data-id="68" data-set="MSK1236" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off68" style="top:763px;left:273px;"> MSK1/2</div> <div id="el68_ct" class="pw-tooltip" data-id="68"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/msk1">MSK1</a><br><a target="_blank" href="/target/msk2">MSK2</a><br> </div> </div> <div id="el69_gry" class="type_i_ifn_signaling pw-sprite el-gray69 pw-gray" style="top:814px;left:273px;"> </div> <div id="el69_off" data-id="69" data-set="CREB37" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off69" style="top:814px;left:273px;"> </div> <div id="el69_ct" class="pw-tooltip" data-id="69"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/creb">CREB</a><br> </div> </div> <div id="el70_gry" class="type_i_ifn_signaling pw-label el-gray70 pw-gray" style="top:817px;left:246px;"> CREB </div> <div id="el70_off" data-id="70" data-set="CREB37" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off70" style="top:817px;left:246px;"> CREB</div> <div id="el70_ct" class="pw-tooltip" data-id="70"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/creb">CREB</a><br> </div> </div> <div id="el71_gry" class="type_i_ifn_signaling pw-sprite el-gray71 pw-gray" style="top:815px;left:291px;"> </div> <div id="el71_off" data-id="71" data-set="HistoneH338" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off71" style="top:815px;left:291px;"> </div> <div id="el71_ct" class="pw-tooltip" data-id="71"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/histone-h3">Histone H3</a><br> </div> </div> <div id="el72_gry" class="type_i_ifn_signaling pw-label el-gray72 pw-gray" style="top:809px;left:317px;"> Histone H3 </div> <div id="el72_off" data-id="72" data-set="HistoneH338" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off72" style="top:809px;left:317px;"> Histone H3</div> <div id="el72_ct" class="pw-tooltip" data-id="72"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/histone-h3">Histone H3</a><br> </div> </div> <div id="el73_gry" class="type_i_ifn_signaling pw-label2 el-gray73 pw-gray" style="top:545px;left:391px;"> <h2 class="pw_txtBox">Growth<br>Inhibition</h2> </div> <div id="el73_off" data-id="73" data-set="GrowthInhibition" data-type="" class="type_i_ifn_signaling pw-label2 el-off73" style="top:545px;left:391px;"> <h2 class="pw_txtBox">Growth<br>Inhibition</h2></div> <div id="el73_ct" class="pw-tooltip" data-id="73"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el74_gry" class="type_i_ifn_signaling pw-label2 el-gray74 pw-gray" style="top:886px;left:235px;"> Chromatin Remodeling </div> <div id="el74_off" data-id="74" data-set="ChromatinRemodeling" data-type="" class="type_i_ifn_signaling pw-label2 el-off74" style="top:886px;left:235px;"> Chromatin Remodeling</div> <div id="el74_ct" class="pw-tooltip" data-id="74"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el75_gry" class="type_i_ifn_signaling pw-sprite el-gray75 pw-gray" style="top:279px;left:438px;"> </div> <div id="el75_off" data-id="75" data-set="STAT141" data-type="" class="type_i_ifn_signaling pw-sprite el-off75" style="top:279px;left:438px;"> </div> <div id="el75_ct" class="pw-tooltip" data-id="75"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br><a target="_blank" href="/target/stat2">STAT2</a><br> </div> </div> <div id="el76_gry" class="type_i_ifn_signaling pw-label el-gray76 pw-gray" style="top:288px;left:451px;"> STAT1 </div> <div id="el76_off" data-id="76" data-set="STAT141" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off76" style="top:288px;left:451px;"> STAT1</div> <div id="el76_ct" class="pw-tooltip" data-id="76"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br><a target="_blank" href="/target/stat2">STAT2</a><br> </div> </div> <div id="el77_gry" class="type_i_ifn_signaling pw-sprite el-gray77 pw-gray" style="top:417px;left:440px;"> </div> <div id="el77_off" data-id="77" data-set="STAT142" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off77" style="top:417px;left:440px;"> </div> <div id="el77_ct" class="pw-tooltip" data-id="77"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el78_gry" class="type_i_ifn_signaling pw-label el-gray78 pw-gray" style="top:429px;left:424px;"> STAT1 </div> <div id="el78_off" data-id="78" data-set="STAT142" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off78" style="top:429px;left:424px;"> STAT1</div> <div id="el78_ct" class="pw-tooltip" data-id="78"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el79_gry" class="type_i_ifn_signaling pw-sprite el-gray79 pw-gray" style="top:417px;left:461px;"> </div> <div id="el79_off" data-id="79" data-set="STAT243" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off79" style="top:417px;left:461px;"> </div> <div id="el79_ct" class="pw-tooltip" data-id="79"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat2">STAT2</a><br> </div> </div> <div id="el80_gry" class="type_i_ifn_signaling pw-label el-gray80 pw-gray" style="top:429px;left:474px;"> STAT2 </div> <div id="el80_off" data-id="80" data-set="STAT243" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off80" style="top:429px;left:474px;"> STAT2</div> <div id="el80_ct" class="pw-tooltip" data-id="80"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat2">STAT2</a><br> </div> </div> <div id="el81_gry" class="type_i_ifn_signaling pw-sprite el-gray81 pw-gray" style="top:462px;left:488px;"> </div> <div id="el81_off" data-id="81" data-set="IRF944" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off81" style="top:462px;left:488px;"> </div> <div id="el81_ct" class="pw-tooltip" data-id="81"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/irf9">IRF9</a><br> </div> </div> <div id="el82_gry" class="type_i_ifn_signaling pw-label el-gray82 pw-gray" style="top:473px;left:497px;"> IRF9 </div> <div id="el82_off" data-id="82" data-set="IRF944" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off82" style="top:473px;left:497px;"> IRF9</div> <div id="el82_ct" class="pw-tooltip" data-id="82"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/irf9">IRF9</a><br> </div> </div> <div id="el83_gry" class="type_i_ifn_signaling pw-sprite el-gray83 pw-gray" style="top:560px;left:485px;"> </div> <div id="el83_off" data-id="83" data-set="STAT145" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off83" style="top:560px;left:485px;"> </div> <div id="el83_ct" class="pw-tooltip" data-id="83"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el84_gry" class="type_i_ifn_signaling pw-label el-gray84 pw-gray" style="top:593px;left:470px;"> STAT1 </div> <div id="el84_off" data-id="84" data-set="STAT145" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off84" style="top:593px;left:470px;"> STAT1</div> <div id="el84_ct" class="pw-tooltip" data-id="84"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el85_gry" class="type_i_ifn_signaling pw-sprite el-gray85 pw-gray" style="top:562px;left:505px;"> </div> <div id="el85_off" data-id="85" data-set="STAT246" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off85" style="top:562px;left:505px;"> </div> <div id="el85_ct" class="pw-tooltip" data-id="85"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat2">STAT2</a><br> </div> </div> <div id="el86_gry" class="type_i_ifn_signaling pw-label el-gray86 pw-gray" style="top:593px;left:519px;"> STAT2 </div> <div id="el86_off" data-id="86" data-set="STAT246" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off86" style="top:593px;left:519px;"> STAT2</div> <div id="el86_ct" class="pw-tooltip" data-id="86"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat2">STAT2</a><br> </div> </div> <div id="el87_gry" class="type_i_ifn_signaling pw-sprite el-gray87 pw-gray" style="top:544px;left:494px;"> </div> <div id="el87_off" data-id="87" data-set="IRF947" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off87" style="top:544px;left:494px;"> </div> <div id="el87_ct" class="pw-tooltip" data-id="87"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/irf9">IRF9</a><br> </div> </div> <div id="el88_gry" class="type_i_ifn_signaling pw-label el-gray88 pw-gray" style="top:550px;left:471px;"> IRF9 </div> <div id="el88_off" data-id="88" data-set="IRF947" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off88" style="top:550px;left:471px;"> IRF9</div> <div id="el88_ct" class="pw-tooltip" data-id="88"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/irf9">IRF9</a><br> </div> </div> <div id="el89_gry" class="type_i_ifn_signaling pw-label2 el-gray89 pw-gray" style="top:566px;left:552px;"> ISGF3 </div> <div id="el89_off" data-id="89" data-set="ISGF3" data-type="" class="type_i_ifn_signaling pw-label2 el-off89" style="top:566px;left:552px;"> ISGF3</div> <div id="el89_ct" class="pw-tooltip" data-id="89"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el90_gry" class="type_i_ifn_signaling pw-sprite el-gray90 pw-gray" style="top:802px;left:457px;"> </div> <div id="el90_off" data-id="90" data-set="STAT149" data-type="" class="type_i_ifn_signaling pw-sprite el-off90" style="top:802px;left:457px;"> </div> <div id="el90_ct" class="pw-tooltip" data-id="90"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el91_gry" class="type_i_ifn_signaling pw-label el-gray91 pw-gray" style="top:811px;left:420px;"> STAT1 </div> <div id="el91_off" data-id="91" data-set="STAT149" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off91" style="top:811px;left:420px;"> STAT1</div> <div id="el91_ct" class="pw-tooltip" data-id="91"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el92_gry" class="type_i_ifn_signaling pw-sprite el-gray92 pw-gray" style="top:803px;left:475px;"> </div> <div id="el92_off" data-id="92" data-set="STAT250" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off92" style="top:803px;left:475px;"> </div> <div id="el92_ct" class="pw-tooltip" data-id="92"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat2">STAT2</a><br> </div> </div> <div id="el93_gry" class="type_i_ifn_signaling pw-label el-gray93 pw-gray" style="top:797px;left:505px;"> STAT2 </div> <div id="el93_off" data-id="93" data-set="STAT250" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off93" style="top:797px;left:505px;"> STAT2</div> <div id="el93_ct" class="pw-tooltip" data-id="93"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat2">STAT2</a><br> </div> </div> <div id="el94_gry" class="type_i_ifn_signaling pw-sprite el-gray94 pw-gray" style="top:787px;left:463px;"> </div> <div id="el94_off" data-id="94" data-set="IRF951" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off94" style="top:787px;left:463px;"> </div> <div id="el94_ct" class="pw-tooltip" data-id="94"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/irf9">IRF9</a><br> </div> </div> <div id="el95_gry" class="type_i_ifn_signaling pw-label el-gray95 pw-gray" style="top:791px;left:453px;"> IRF9 </div> <div id="el95_off" data-id="95" data-set="IRF951" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off95" style="top:791px;left:453px;"> IRF9</div> <div id="el95_ct" class="pw-tooltip" data-id="95"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/irf9">IRF9</a><br> </div> </div> <div id="el96_gry" class="type_i_ifn_signaling pw-label2 el-gray96 pw-gray" style="top:876px;left:426px;"> IFN-Stimulated Genes </div> <div id="el96_off" data-id="96" data-set="IFN-StimulatedGenes" data-type="" class="type_i_ifn_signaling pw-label2 el-off96" style="top:876px;left:426px;"> IFN-Stimulated Genes</div> <div id="el96_ct" class="pw-tooltip" data-id="96"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el97_gry" class="type_i_ifn_signaling pw-label2 el-gray97 pw-gray" style="top:896px;left:426px;"> Anti-Viral Response </div> <div id="el97_off" data-id="97" data-set="Anti-ViralResponse" data-type="" class="type_i_ifn_signaling pw-label2 el-off97" style="top:896px;left:426px;"> Anti-Viral Response</div> <div id="el97_ct" class="pw-tooltip" data-id="97"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el98_gry" class="type_i_ifn_signaling pw-sprite el-gray98 pw-gray" style="top:449px;left:564px;"> </div> <div id="el98_off" data-id="98" data-set="STAT154" data-type="" class="type_i_ifn_signaling pw-sprite el-off98" style="top:449px;left:564px;"> </div> <div id="el98_ct" class="pw-tooltip" data-id="98"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el99_gry" class="type_i_ifn_signaling pw-label el-gray99 pw-gray" style="top:462px;left:549px;"> STAT1 </div> <div id="el99_off" data-id="99" data-set="STAT154" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off99" style="top:462px;left:549px;"> STAT1</div> <div id="el99_ct" class="pw-tooltip" data-id="99"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el100_gry" class="type_i_ifn_signaling pw-sprite el-gray100 pw-gray" style="top:451px;left:587px;"> </div> <div id="el100_off" data-id="100" data-set="STAT155" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off100" style="top:451px;left:587px;"> </div> <div id="el100_ct" class="pw-tooltip" data-id="100"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el101_gry" class="type_i_ifn_signaling pw-label el-gray101 pw-gray" style="top:462px;left:596px;"> STAT1 </div> <div id="el101_off" data-id="101" data-set="STAT155" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off101" style="top:462px;left:596px;"> STAT1</div> <div id="el101_ct" class="pw-tooltip" data-id="101"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br> </div> </div> <div id="el102_gry" class="type_i_ifn_signaling pw-sprite el-gray102 pw-gray" style="top:240px;left:501px;"> </div> <div id="el102_off" data-id="102" data-set="STAT356" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off102" style="top:240px;left:501px;"> </div> <div id="el102_ct" class="pw-tooltip" data-id="102"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat3">STAT3</a><br><a target="_blank" href="/target/stat4">STAT4</a><br><a target="_blank" href="/target/stat5a">STAT5a</a><br><a target="_blank" href="/target/stat5b">STAT5b</a><br><a target="_blank" href="/target/stat6">STAT6</a><br> </div> </div> <div id="el103_gry" class="type_i_ifn_signaling pw-label el-gray103 pw-gray" style="top:268px;left:512px;"> STAT3 </div> <div id="el103_off" data-id="103" data-set="STAT356" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off103" style="top:268px;left:512px;"> STAT3</div> <div id="el103_ct" class="pw-tooltip" data-id="103"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat3">STAT3</a><br><a target="_blank" href="/target/stat4">STAT4</a><br><a target="_blank" href="/target/stat5a">STAT5a</a><br><a target="_blank" href="/target/stat5b">STAT5b</a><br><a target="_blank" href="/target/stat6">STAT6</a><br> </div> </div> <div id="el104_gry" class="type_i_ifn_signaling pw-label2 el-gray104 pw-gray" style="top:277px;left:573px;"> Homo-/<br>Heterodimers </div> <div id="el104_off" data-id="104" data-set="Homo-Heterodimers" data-type="" class="type_i_ifn_signaling pw-label2 el-off104" style="top:277px;left:573px;"> Homo-/<br>Heterodimers</div> <div id="el104_ct" class="pw-tooltip" data-id="104"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el105_gry" class="type_i_ifn_signaling pw-sprite el-gray105 pw-gray" style="top:826px;left:634px;"> </div> <div id="el105_off" data-id="105" data-set="STATDimerorCrkL-STAT558" data-type="" class="type_i_ifn_signaling pw-sprite el-off105" style="top:826px;left:634px;"> </div> <div id="el105_ct" class="pw-tooltip" data-id="105"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/crkl">CrkL</a><br><a target="_blank" href="/target/stat1">STAT1</a><br><a target="_blank" href="/target/stat3">STAT3</a><br><a target="_blank" href="/target/stat4">STAT4</a><br><a target="_blank" href="/target/stat5a">STAT5a</a><br><a target="_blank" href="/target/stat5b">STAT5b</a><br><a target="_blank" href="/target/stat6">STAT6</a><br> </div> </div> <div id="el106_gry" class="type_i_ifn_signaling pw-label pw-center el-gray106 pw-gray" style="top:802px;left:632px;"> STAT Dimer<br>or CrkL-STAT5 </div> <div id="el106_off" data-id="106" data-set="STATDimerorCrkL-STAT558" data-type="No Products Click" class="type_i_ifn_signaling pw-label pw-center el-off106" style="top:802px;left:632px;"> STAT Dimer<br>or CrkL-STAT5 </div> <div id="el106_ct" class="pw-tooltip" data-id="106"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/crkl">CrkL</a><br><a target="_blank" href="/target/stat1">STAT1</a><br><a target="_blank" href="/target/stat3">STAT3</a><br><a target="_blank" href="/target/stat4">STAT4</a><br><a target="_blank" href="/target/stat5a">STAT5a</a><br><a target="_blank" href="/target/stat5b">STAT5b</a><br><a target="_blank" href="/target/stat6">STAT6</a><br> </div> </div> <div id="el107_gry" class="type_i_ifn_signaling pw-label2 pw-center el-gray107 pw-gray" style="top:903px;left:621px;"> Regulation of the<br>Inflammatory Response </div> <div id="el107_off" data-id="107" data-set="RegulationoftheInflammatoryResponse" data-type="" class="type_i_ifn_signaling pw-label2 pw-center el-off107" style="top:903px;left:621px;"> Regulation of the<br>Inflammatory Response</div> <div id="el107_ct" class="pw-tooltip" data-id="107"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el108_gry" class="type_i_ifn_signaling pw-sprite el-gray108 pw-gray" style="top:195px;left:586px;"> </div> <div id="el108_off" data-id="108" data-set="crklsprite" data-type="" class="type_i_ifn_signaling pw-sprite el-off108" style="top:195px;left:586px;"> </div> <div id="el108_ct" class="pw-tooltip" data-id="108"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/crkl">CrkL</a> </div> </div> <div id="el109_gry" class="type_i_ifn_signaling pw-label el-gray109 pw-gray" style="top:204px;left:625px;"> CrkL </div> <div id="el109_off" data-id="109" data-set="crklsprite" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off109" style="top:204px;left:625px;"> CrkL</div> <div id="el109_ct" class="pw-tooltip" data-id="109"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/crkl">CrkL</a> </div> </div> <div id="el110_gry" class="type_i_ifn_signaling pw-sprite el-gray110 pw-gray" style="top:215px;left:587px;"> </div> <div id="el110_off" data-id="110" data-set="STAT5" data-type="No Products Click" class="type_i_ifn_signaling pw-sprite el-off110" style="top:215px;left:587px;"> </div> <div id="el110_ct" class="pw-tooltip" data-id="110"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat5a">STAT5a</a><br> <a target="_blank" href="/target/stat5b">STAT5b</a> </div> </div> <div id="el111_gry" class="type_i_ifn_signaling pw-label el-gray111 pw-gray" style="top:225px;left:626px;"> STAT5 </div> <div id="el111_off" data-id="111" data-set="STAT5" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off111" style="top:225px;left:626px;"> STAT5</div> <div id="el111_ct" class="pw-tooltip" data-id="111"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat5a">STAT5a</a><br> <a target="_blank" href="/target/stat5b">STAT5b</a> </div> </div> <div id="el112_gry" class="type_i_ifn_signaling pw-label el-gray112 pw-gray" style="top:304px;left:451px;"> STAT2 </div> <div id="el112_off" data-id="112" data-set="STAT141" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off112" style="top:304px;left:451px;"> STAT2</div> <div id="el112_ct" class="pw-tooltip" data-id="112"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat1">STAT1</a><br><a target="_blank" href="/target/stat2">STAT2</a><br> </div> </div> <div id="el113_gry" class="type_i_ifn_signaling pw-label el-gray113 pw-gray" style="top:282px;left:512px;"> STAT4 </div> <div id="el113_off" data-id="113" data-set="STAT356" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off113" style="top:282px;left:512px;"> STAT4</div> <div id="el113_ct" class="pw-tooltip" data-id="113"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat3">STAT3</a><br><a target="_blank" href="/target/stat4">STAT4</a><br><a target="_blank" href="/target/stat5a">STAT5a</a><br><a target="_blank" href="/target/stat5b">STAT5b</a><br><a target="_blank" href="/target/stat6">STAT6</a><br> </div> </div> <div id="el114_gry" class="type_i_ifn_signaling pw-label el-gray114 pw-gray" style="top:301px;left:512px;"> STAT5 </div> <div id="el114_off" data-id="114" data-set="STAT356" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off114" style="top:301px;left:512px;"> STAT5</div> <div id="el114_ct" class="pw-tooltip" data-id="114"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat3">STAT3</a><br><a target="_blank" href="/target/stat4">STAT4</a><br><a target="_blank" href="/target/stat5a">STAT5a</a><br><a target="_blank" href="/target/stat5b">STAT5b</a><br><a target="_blank" href="/target/stat6">STAT6</a><br> </div> </div> <div id="el115_gry" class="type_i_ifn_signaling pw-label el-gray115 pw-gray" style="top:318px;left:512px;"> STAT6 </div> <div id="el115_off" data-id="115" data-set="STAT356" data-type="No Products Click" class="type_i_ifn_signaling pw-label el-off115" style="top:318px;left:512px;"> STAT6</div> <div id="el115_ct" class="pw-tooltip" data-id="115"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a target="_blank" href="/target/stat3">STAT3</a><br><a target="_blank" href="/target/stat4">STAT4</a><br><a target="_blank" href="/target/stat5a">STAT5a</a><br><a target="_blank" href="/target/stat5b">STAT5b</a><br><a target="_blank" href="/target/stat6">STAT6</a><br> </div> </div> <div id="el116_gry" class="type_i_ifn_signaling pw-label2 el-gray116 pw-gray" style="top:837px;left:465px;"> <h2 class="pw_txtBox">ISRE</h2> </div> <div id="el116_off" data-id="116" data-set="isre" data-type="" class="type_i_ifn_signaling pw-label2 el-off116" style="top:837px;left:465px;"> <h2 class="pw_txtBox">ISRE</h2></div> <div id="el116_ct" class="pw-tooltip" data-id="116"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el117_gry" class="type_i_ifn_signaling pw-label2 el-gray117 pw-gray" style="top:862px;left:652px;"> <h2 class="pw_txtBox">GAS</h2> </div> <div id="el117_off" data-id="117" data-set="isre" data-type="" class="type_i_ifn_signaling pw-label2 el-off117" style="top:862px;left:652px;"> <h2 class="pw_txtBox">GAS</h2></div> <div id="el117_ct" class="pw-tooltip" data-id="117"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> </div> <div id="pw-img"> <img id="cont-img" src="https://resources.rndsystems.com/images/Pathways/pathway-images/interferons_type_1_bg.png?t=2" alt="Type I Interferon Signaling Pathways" style="height:1022px"> </div> </div> <div id="pathway-description"><p><div class="row"> <div class="col-md-4 col-xs-12"> <div class="featured-box"> <h2>Featured Literature</h2> <img id="gray" src="//resources.rndsystems.com/images/site/rnd-significant-events-history-virology-poster-thumb.jpg" alt="Significant Events in the History of Virology" width="100%"> <h3>Significant Events in the History of Virology</h3> <a href="/resources/posters/significant-events-history-virology" class="btn btn-senary" target="_blank">View Poster</a> </div> </div> <div class="col-md-4 col-xs-12"> <div class="featured-box"> <h2>Featured Products</h2> <img src="//resources.rndsystems.com/images/site/rnd-interferons-anti-viral-small-molecules-broc-thumb.jpg" alt="Interferons and Anti-Viral Small Molecules" width="100%"> <h3>Interferons and Anti-Viral Small Molecules</h3> <a href="/resources/literature/interferons-anti-viral-small-molecules" class="btn btn-senary" target="_blank">View Brochure</a> </div> </div> <div style="clear:both"> </div> </div> <h2>Overview of Type I Interferon Signaling Pathways</h2> <style type="text/css"> .container_16 {padding:0px !important;} .main.grid_16, .grid_16.base_rnd_css {width:1170px !important;} #pw-nav-con { width: 750px; height: inherit !important; background: none; } #pw-nav-con H2 { margin: 7px 0 5px 16px; padding: 5px 0; font-size: 19px; font-weight: inherit; width: 730px; border: none; } #pw-nav-con ul { margin: 0; padding: 0; height: 40px; } .pw-blu-btn { width: inherit; float: left; margin-left: 15px;} #pw-nav-con .pw-blu-btn a { background: #005F9E; border-top: 1px solid #005f9f;} #pw-nav-con .pw-blu-btn-active { border-top: none;} #pw-nav-con .pw-drk-blu-btn, #pw-nav-con li a /*request print button*/ { display: initial; padding: 5px 10px; font-weight: bold; background: #ffffff; border: 1px solid #005f9f; color: #090909; border-radius: 4px;} #pw-nav-con .pw-blu-btn-active { margin-left: 15px; float: left;} .related-information { background: #efefef; border: 1px solid #cccccc; position: relative; top: -54px;} .featured-links { display: block; text-decoration: none;} </style> <p>Type I IFNs are produced following recognition of microbial products by cell surface and intracellular pattern recognition receptors. The type I interferon (IFN) family consists of multiple IFN-alpha subtypes, IFN-beta, IFN-delta, IFN-epsilon, IFN-kappa, IFN-tau, IFN-omega, and IFN-zeta/Limitin. IFN-alpha, IFN-beta, IFN-epsilon, IFN-kappa, and IFN-omega are all found in humans, while IFN-delta, IFN-tau, and IFN-zeta have only been described in pigs, cattle, and mice, respectively. No human homologues of these three type I interferon subclasses have been identified. All type I interferons have significant structural homology and bind to a common heterodimeric receptor consisting of the IFN-alpha/beta RI and IFN-alpha/beta R2 subunits, which are expressed on most cell types. Receptor engagement activates the IFN-alpha/beta R1-associated Tyk2 protein tyrosine kinase and the IFN-alpha/beta R2-associated Jak1 protein tyrosine kinase. These kinases subsequently regulate the phosphorylation and activation of different STAT proteins. Activated STAT proteins homo- or heterodimerize and translocate to the nucleus, where they promote the expression of numerous target genes. In addition, type I IFNs activate the MAPK, PI 3-K-Akt, and NF-kappa B signaling pathways. One transcriptional complex that is formed following stimulation by type I IFNs is the IFN-stimulated gene factor 3 (ISGF3) complex. This complex consists of phosphorylated STAT1, STAT2, and IRF9 and binds to IFN-stimulated response elements (ISREs) found in the promoters of numerous IFN-stimulated genes (ISGs). Other STAT homo- or heterodimers induced by type I IFNs bind to regulatory sequences in the promoters of target genes known as IFN-gamma-activated sequence (GAS) sites. Binding of STAT proteins to either ISREs or GAS sites regulates the expression of several hundred ISGs, which mediate the anti-viral, anti-proliferative, and apoptotic effects of type I IFNs.</p> <p>To learn more, please visit our <a href="/research-area/interferons">Interferons Research Area page</a></p> <p> </p> <h2>Immunoassays for Type 1 IFN Research</h2> <p>See how <a href="https://www.bio-techne.com/methods/immunoassays/type1-interferon-immunoassays" target="_blank">R&D Systems Type 1 IFN ELISA kits</a> compare to the competition. Find out how you can move seamlessly from one immunoassay platform to the next as your needs change.</p> <p><a href="https://www.bio-techne.com/methods/immunoassays/type1-interferon-immunoassays">See the Type 1 IFN ELISA Linearity and Recovery Data</a></p>  </p></div> <div id="print-copy-form" class="accordion-wrapper"> <h3 class="builder-header builder-bead-type ui-accordion-header ui-helper-reset ui-state-default ui-corner-all ui-accordion-icons" data-toggle="collapse" data-target="#collapsePathwayRequest" aria-expanded="false" id="pathwayRequestAccordionHeader"> <span class="ui-accordion-header-icon" id="accordionArrow"></span> Get Print Copy of this Pathway </h3> <div class="collapse" id="collapsePathwayRequest"> <div id="pathwayRequestWebformWrapper"> <form class="webform-client-form webform-client-form-27981" action="/pathways/type-i-interferon-signaling-pathways" method="post" id="webform-client-form-27981" accept-charset="UTF-8"><div><div class="form-item webform-component webform-component-textfield webform-component--first-name form-group form-item form-item-submitted-first-name form-type-textfield form-group"> <label class="control-label" for="edit-submitted-first-name">First Name <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-first-name" name="submitted[first_name]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-textfield webform-component--last-name form-group form-item form-item-submitted-last-name form-type-textfield form-group"> <label class="control-label" for="edit-submitted-last-name">Last Name <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-last-name" name="submitted[last_name]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-email webform-component--email-address form-group form-item form-item-submitted-email-address form-type-webform-email form-group"> <label class="control-label" for="edit-submitted-email-address">Email Address <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="email form-control form-text form-email required" type="email" id="edit-submitted-email-address" name="submitted[email_address]" size="60" /></div><div class="form-item webform-component webform-component-textfield webform-component--institution form-group form-item form-item-submitted-institution form-type-textfield form-group"> <label class="control-label" for="edit-submitted-institution">Institution <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-institution" name="submitted[institution]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-textfield webform-component--job-title form-group form-item form-item-submitted-job-title form-type-textfield form-group"> <label class="control-label" for="edit-submitted-job-title">Job Title</label> <input class="form-control form-text" type="text" id="edit-submitted-job-title" name="submitted[job_title]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-textfield webform-component--department form-group form-item form-item-submitted-department form-type-textfield form-group"> <label class="control-label" for="edit-submitted-department">Department</label> <input class="form-control form-text" type="text" id="edit-submitted-department" name="submitted[department]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-textfield webform-component--address-1 form-group form-item form-item-submitted-address-1 form-type-textfield form-group"> <label class="control-label" for="edit-submitted-address-1">Address 1 <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-address-1" name="submitted[address_1]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-textfield webform-component--address-2 form-group form-item form-item-submitted-address-2 form-type-textfield form-group"> <label class="control-label" for="edit-submitted-address-2">Address 2</label> <input class="form-control form-text" type="text" id="edit-submitted-address-2" name="submitted[address_2]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-textfield webform-component--city form-group form-item form-item-submitted-city form-type-textfield form-group"> <label class="control-label" for="edit-submitted-city">City <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-city" name="submitted[city]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-select webform-component--state form-group form-item form-item-submitted-state form-type-select form-group"> <label class="control-label" for="edit-submitted-state">State</label> <div class="select_wrapper"><select class="form-control form-select" id="edit-submitted-state" name="submitted[state]"><option value="" selected="selected">- None -</option><option value="AL">Alabama</option><option value="AK">Alaska</option><option value="AS">American Samoa</option><option value="AZ">Arizona</option><option value="AR">Arkansas</option><option value="CA">California</option><option value="CO">Colorado</option><option value="CT">Connecticut</option><option value="DE">Delaware</option><option value="DC">District of Columbia</option><option value="FL">Florida</option><option value="GA">Georgia</option><option value="GU">Guam</option><option value="HI">Hawaii</option><option value="ID">Idaho</option><option value="IL">Illinois</option><option value="IN">Indiana</option><option value="IA">Iowa</option><option value="KS">Kansas</option><option value="KY">Kentucky</option><option value="LA">Louisiana</option><option value="ME">Maine</option><option value="MH">Marshall Islands</option><option value="MD">Maryland</option><option value="MA">Massachusetts</option><option value="MI">Michigan</option><option value="MN">Minnesota</option><option value="MS">Mississippi</option><option value="MO">Missouri</option><option value="MT">Montana</option><option value="NE">Nebraska</option><option value="NV">Nevada</option><option value="NH">New Hampshire</option><option value="NJ">New Jersey</option><option value="NM">New Mexico</option><option value="NY">New York</option><option value="NC">North Carolina</option><option value="ND">North Dakota</option><option value="MP">Northern Marianas Islands</option><option value="OH">Ohio</option><option value="OK">Oklahoma</option><option value="OR">Oregon</option><option value="PW">Palau</option><option value="PA">Pennsylvania</option><option value="PR">Puerto Rico</option><option value="RI">Rhode Island</option><option value="SC">South Carolina</option><option value="SD">South Dakota</option><option value="TN">Tennessee</option><option value="TX">Texas</option><option value="UT">Utah</option><option value="VT">Vermont</option><option value="VI">Virgin Islands</option><option value="VA">Virginia</option><option value="WA">Washington</option><option value="WV">West Virginia</option><option value="WI">Wisconsin</option><option value="WY">Wyoming</option></select></div></div><div class="form-item webform-component webform-component-textfield webform-component--postal-code form-group form-item form-item-submitted-postal-code form-type-textfield form-group"> <label class="control-label" for="edit-submitted-postal-code">Postal Code <span class="form-required" title="This field is required.">*</span></label> <input required="required" class="form-control form-text required" type="text" id="edit-submitted-postal-code" name="submitted[postal_code]" value="" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-select webform-component--country form-group form-item form-item-submitted-country form-type-select form-group"> <label class="control-label" for="edit-submitted-country">Country</label> <div class="select_wrapper"><select class="form-control form-select" id="edit-submitted-country" name="submitted[country]"><option value="" selected="selected">- None -</option><option value="AL">Albania</option><option value="DZ">Algeria</option><option value="AD">Andorra</option><option value="AO">Angola</option><option value="AG">Antigua and Barbuda</option><option value="AR">Argentina</option><option value="AM">Armenia</option><option value="AW">Aruba</option><option value="AU">Australia</option><option value="AT">Austria</option><option value="AZ">Azerbaijan</option><option value="BS">Bahamas</option><option value="BH">Bahrain</option><option value="BD">Bangladesh</option><option value="BB">Barbados</option><option value="BE">Belgium</option><option value="BZ">Belize</option><option value="BJ">Benin</option><option value="BM">Bermuda</option><option value="BO">Bolivia</option><option value="BA">Bosnia and Herzegovina</option><option value="BW">Botswana</option><option value="BR">Brazil</option><option value="BN">Brunei</option><option value="BG">Bulgaria</option><option value="BF">Burkina Faso</option><option value="BI">Burundi</option><option value="KH">Cambodia</option><option value="CM">Cameroon</option><option value="CA">Canada</option><option value="KY">Cayman Islands</option><option value="CF">Central African Republic</option><option value="TD">Chad</option><option value="CL">Chile</option><option value="CN">China</option><option value="CO">Colombia</option><option value="CR">Costa Rica</option><option value="HR">Croatia</option><option value="CY">Cyprus</option><option value="CZ">Czech Republic</option><option value="DK">Denmark</option><option value="DJ">Djibouti</option><option value="DM">Dominica</option><option value="DO">Dominican Republic</option><option value="EC">Ecuador</option><option value="EG">Egypt</option><option value="SV">El Salvador</option><option value="GQ">Equatorial Guinea</option><option value="ER">Eritrea</option><option value="EE">Estonia</option><option value="ET">Ethiopia</option><option value="FK">Falkland Islands</option><option value="FJ">Fiji</option><option value="FI">Finland</option><option value="FR">France</option><option value="PF">French Polynesia</option><option value="GA">Gabon</option><option value="GM">Gambia</option><option value="GE">Georgia</option><option value="DE">Germany</option><option value="GH">Ghana</option><option value="GI">Gibraltar</option><option value="GR">Greece</option><option value="GD">Grenada</option><option value="GP">Guadeloupe</option><option value="GU">Guam</option><option value="GT">Guatemala</option><option value="GN">Guinea</option><option value="GW">Guinea-Bissau</option><option value="GY">Guyana</option><option value="HT">Haiti</option><option value="HN">Honduras</option><option value="HK">Hong Kong S.A.R., China</option><option value="HU">Hungary</option><option value="IS">Iceland</option><option value="IN">India</option><option value="ID">Indonesia</option><option value="IQ">Iraq</option><option value="IE">Ireland</option><option value="IL">Israel</option><option value="IT">Italy</option><option value="CI">Ivory Coast</option><option value="JM">Jamaica</option><option value="JP">Japan</option><option value="JO">Jordan</option><option value="KZ">Kazakhstan</option><option value="KE">Kenya</option><option value="KW">Kuwait</option><option value="KG">Kyrgyzstan</option><option value="LV">Latvia</option><option value="LB">Lebanon</option><option value="LS">Lesotho</option><option value="LR">Liberia</option><option value="LI">Liechtenstein</option><option value="LT">Lithuania</option><option value="LU">Luxembourg</option><option value="MK">Macedonia</option><option value="MG">Madagascar</option><option value="MW">Malawi</option><option value="MY">Malaysia</option><option value="ML">Mali</option><option value="MT">Malta</option><option value="MH">Marshall Islands</option><option value="MR">Mauritania</option><option value="MX">Mexico</option><option value="MD">Moldova</option><option value="MC">Monaco</option><option value="MN">Mongolia</option><option value="ME">Montenegro</option><option value="MA">Morocco</option><option value="MZ">Mozambique</option><option value="MM">Myanmar</option><option value="NA">Namibia</option><option value="NP">Nepal</option><option value="NL">Netherlands</option><option value="AN">Netherlands Antilles</option><option value="NC">New Caledonia</option><option value="NZ">New Zealand</option><option value="NI">Nicaragua</option><option value="NE">Niger</option><option value="NG">Nigeria</option><option value="MP">Northern Mariana Islands</option><option value="NO">Norway</option><option value="OM">Oman</option><option value="PK">Pakistan</option><option value="PW">Palau</option><option value="PA">Panama</option><option value="PG">Papua New Guinea</option><option value="PY">Paraguay</option><option value="PE">Peru</option><option value="PH">Philippines</option><option value="PL">Poland</option><option value="PT">Portugal</option><option value="PR">Puerto Rico</option><option value="QA">Qatar</option><option value="RO">Romania</option><option value="RW">Rwanda</option><option value="KN">Saint Kitts and Nevis</option><option value="LC">Saint Lucia</option><option value="MF">Saint Martin (French part)</option><option value="WS">Samoa</option><option value="SA">Saudi Arabia</option><option value="SN">Senegal</option><option value="RS">Serbia</option><option value="SL">Sierra Leone</option><option value="SG">Singapore</option><option value="SK">Slovakia</option><option value="SI">Slovenia</option><option value="SB">Solomon Islands</option><option value="ZA">South Africa</option><option value="KR">South Korea</option><option value="ES">Spain</option><option value="LK">Sri Lanka</option><option value="SR">Suriname</option><option value="SZ">Swaziland</option><option value="SE">Sweden</option><option value="CH">Switzerland</option><option value="TW">Taiwan, China</option><option value="TZ">Tanzania</option><option value="TH">Thailand</option><option value="TG">Togo</option><option value="TT">Trinidad and Tobago</option><option value="TN">Tunisia</option><option value="TR">Turkey</option><option value="UG">Uganda</option><option value="UA">Ukraine</option><option value="AE">United Arab Emirates</option><option value="GB">United Kingdom</option><option value="US">United States</option><option value="UY">Uruguay</option><option value="UZ">Uzbekistan</option><option value="VA">Vatican</option><option value="VE">Venezuela</option><option value="VN">Vietnam</option><option value="YE">Yemen</option><option value="ZM">Zambia</option><option value="ZW">Zimbabwe</option></select></div></div><div class="form-item webform-component webform-component-textfield webform-component--pathway form-group form-item form-item-submitted-pathway form-type-textfield form-group"> <label class="control-label" for="edit-submitted-pathway">Pathway</label> <input readonly="readonly" class="form-control form-text" type="text" id="edit-submitted-pathway" name="submitted[pathway]" value="Type I Interferon Signaling Pathways" size="60" maxlength="128" /></div><div class="form-item webform-component webform-component-checkboxes webform-component--may-we-contact-you form-group form-item form-item-submitted-may-we-contact-you form-type-checkboxes form-group"> <label class="control-label" for="edit-submitted-may-we-contact-you">May we contact you?</label> <div id="edit-submitted-may-we-contact-you" class="form-checkboxes"><div class="form-item form-item-submitted-may-we-contact-you-by-checking-this-box form-type-checkbox checkbox"> <label class="control-label" for="edit-submitted-may-we-contact-you-1"><input type="checkbox" id="edit-submitted-may-we-contact-you-1" name="submitted[may_we_contact_you][By checking this box]" value="By checking this box" class="form-checkbox" />By checking this box, I agree to receive relevant marketing communications regarding products, industry news, literature, and events from Bio-Techne and its brands: R&D Systems, Novus Biologicals, Tocris Bioscience, ProteinSimple and Advanced Cell Diagnostics. I understand that I can change my preferences at any time. I further understand that any data provided to Bio-Techne and its brands will be stored, used, and deleted consistent with Bio-Techne’s <a href="/legal-information#privacy" target="_blank">Privacy Notice</a>.</label> </div></div></div><input type="hidden" name="details[sid]" /> <input type="hidden" name="details[page_num]" value="1" /> <input type="hidden" name="details[page_count]" value="1" /> <input type="hidden" name="details[finished]" value="0" /> <input type="hidden" name="form_build_id" value="form-YZaqcsRn4sL3RmX730eiBKt2kPfyD3CUQFG3i4Jw3_Q" /> <input type="hidden" name="form_id" value="webform_client_form_27981" /> <input type="hidden" name="honeypot_time" value="1732697870|1u4qyvfX6leS-kvSPOTxNsSJjKsmqgp7KyFFGh5Q0Vs" /> <div class="et_hnypt-textfield"><div class="form-item form-item-et-hnypt form-type-textfield form-group"> <label class="control-label" for="edit-et-hnypt">Leave this field blank</label> <input autocomplete="off" class="form-control form-text" type="text" id="edit-et-hnypt" name="et_hnypt" value="" size="20" maxlength="128" /></div></div><div class="form-actions"><button class="webform-submit button-primary btn btn-primary form-submit" type="submit" name="op" value="Submit">Submit</button> </div></div></form> </div> </div> </div> <div id="pw-fullimage-con" itemscope="" itemtype="http://schema.org/ImageObject"> <h3 itemprop="name"> <a class="ds-image overview-images" href=" //resources.rndsystems.com/images/Pathways/full-pathway-image/770x1040-interferon-type-1-pathways-googleimage.png" data-toggle="lightbox" onclick="event.preventDefault();" data-title="View Type I Interferon Signaling Pathways Image" title="View Type I Interferon Signaling Pathways Image"> View Type I Interferon Signaling Pathways Image </a> </h3> <a class="ds-image overview-images" href=" //resources.rndsystems.com/images/Pathways/full-pathway-image/770x1040-interferon-type-1-pathways-googleimage.png" data-toggle="lightbox" data-gallery="overview-images" onclick="event.preventDefault();" data-title="Type I Interferon Signaling Pathways" data-footer="Type I Interferon Signaling Pathways" > <img src=" //resources.rndsystems.com/images/Pathways/full-pathway-image/770x1040-interferon-type-1-pathways-googleimage.png" itemprop="contentUrl" alt="Type I Interferon Signaling Pathways" title="Type I Interferon Signaling Pathways"> </a> </div> <div id="relatedinfo"></div> <div id="pw-preload"> <img src="https://resources.rndsystems.com/images/Pathways/pathway-images/interferons_type_1_bg.png?t=2" alt="Type I Interferon Signaling Pathways background image 1"> </div> </div> </div> </div> </div> <script> (function ($) { /* Get Print Copy Button Trigger Form Accordion */ $('#btn-get-print-copy').click(function() { console.log("buttonclick"); $('#collapsePathwayRequest').collapse('show'); }) })(jQuery); </script> </section> </div> <footer id="footer_wrapper" class="container-fluid"> <div id="footer_wrapper_container" class="row"> <div id="footer" class="container"> <div id="footer_container" class="row"> <nav class="footer_column footer_column_1 col-xs-12 col-sm-3"> <div class="region region-footer-column-1"> <section id="block-menu-menu-footer-popular-searches" class="block block-menu clearfix"> <h2 class="block-title">Popular Products</h2> <ul class="menu nav"><li class="first leaf"><a href="/search?category=Proteins%20and%20Enzymes" title="" id="menu-footer-popular-searches-28211">Bioactive Proteins</a></li> <li class="leaf"><a href="/search?category=Luminex%20Assays" title="" id="menu-footer-popular-searches-28216">Luminex Assays</a></li> <li class="leaf"><a href="/search?category=ELISAs" title="" id="menu-footer-popular-searches-28221">ELISA Kits</a></li> <li class="leaf"><a href="/search?category=Small%20Molecules" title="" id="menu-footer-popular-searches-28226">Small Molecules</a></li> <li class="last leaf"><a href="/search?category=Primary%20Antibodies" title="" id="menu-footer-popular-searches-28231">Primary Antibodies</a></li> </ul> </section> </div> </nav> <nav class="footer_column footer_column_2 col-xs-12 col-sm-3"> <div class="region region-footer-column-2"> <section id="block-menu-menu-footer-company-information" class="block block-menu clearfix"> <h2 class="block-title">Company Information</h2> <ul class="menu nav"><li class="first leaf"><a href="/about-us" title="" id="menu-footer-company-information-63901">About Us</a></li> <li class="leaf"><a href="https://www.bio-techne.com/about/careers" id="menu-footer-company-information-63911">Careers</a></li> <li class="leaf"><a href="/quality" title="" id="menu-footer-company-information-63916">R&D Systems Quality</a></li> <li class="last leaf"><a href="https://www.bio-techne.com/brands" id="menu-footer-company-information-24546">Bio-Techne Brands</a></li> </ul> </section> </div> </nav> <nav class="footer_column footer_column_3 col-xs-12 col-sm-3"> <div class="region region-footer-column-3"> <section id="block-menu-menu-footer-support" class="block block-menu clearfix"> <h2 class="block-title">Support</h2> <ul class="menu nav"><li class="first leaf"><a href="/support/contact-us" title="" id="menu-footer-support-32351">Contact Us</a></li> <li class="leaf"><a href="/resources/customer-service-ordering-info" id="menu-footer-support-63931">Ordering R&D Systems Products</a></li> <li class="leaf"><a href="/distributors" title="" id="menu-footer-support-32366">Distributors</a></li> <li class="leaf"><a href="/resources/protocols-troubleshooting-guides" title="" id="menu-footer-support-32371">Protocols</a></li> <li class="last leaf"><a href="/resources/faqs" title="" id="menu-footer-support-24551">FAQs</a></li> </ul> </section> </div> </nav> <div class="footer_column footer_column_4 col-xs-12 col-sm-3"> <div class="region region-footer-column-4"> <section id="block-block-16" class="block block-block clearfix"> <h2 class="block-title">Stay Connected</h2> <p>Get the latest news, product updates, and promotions:</p> <p><a href="/subscribe" rel="nofollow" class="btn btn-primary" title="Subscribe" target="_blank">Subscribe</a></p> <p>Follow R&D Systems:</p> <p> <a class="social_link" href="https://www.facebook.com/RnDSystems" target="_blank" title="R&D Systems on Facebook"><span class="icon-facebook-square"></span></a> <a class="social_link" href="https://x.com/RnDSystems" target="_blank" title="R&D Systems on Twitter"><span class="icon-twitter-square"></span></a> <a class="social_link" href="https://www.youtube.com/user/RnDSystems" target="_blank" title="R&D Systems on YouTube"><span class="icon-youtube-square"></span></a> <a class="social_link" href="https://www.linkedin.com/company/r&d-systems" target="_blank" title="R&D Systems on Linkedin"><span class="icon-linkedin-square"></span></a> </p> </section> </div> </div> </div> </div> </div> </footer> <div id="copyright_wrapper" class="container-fluid"> <div id="copyright_wrapper_container" class="row"> <div id="copyright" class="container"> <div id="copyright_container" class="row"> <div id="copyright_content" class="col-xs-12"> <p> <div class="region region-copyright"> <section id="block-block-21" class="block block-block clearfix"> <div class="copy_left"> <a href="/legal-information" title="Legal Information">Legal</a> | <a href="/legal-information#Terms" title="Terms & Conditions">Terms & Conditions</a> | <a href="/legal-information#privacy" title="Privacy and Cookie Policy">Privacy and Cookie Policy</a> | <a href="/sitemap" title="Sitemap">Sitemap</a> </div> <div class="copy_right">© Copyright 2024 R&D Systems, Inc. All Rights Reserved.</div> </section> </div> </p> </div> </div> </div> </div> </div> <script>var _hmt = _hmt || []; (function() { var hm = document.createElement("script"); hm.async = true; hm.defer = true; hm.src = "//hm.baidu.com/hm.js?9d5a20d7ef7a7e9d0ba4232fd45e5d3f"; var s = document.getElementsByTagName("script")[0]; s.parentNode.insertBefore(hm, s); })();</script> <script src="https://www.rndsystems.com/sites/all/themes/bootstrap/js/bootstrap.js?snl6xl"></script> <script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"76fb58fb05","applicationID":"788348530,30870807","transactionName":"YFdbZBFZXxdWAhAMVlkdeFMXUV4KGA8LAVxoQlhXBmdHDVIW","queueTime":27,"applicationTime":650,"atts":"TBBYEllDTBk=","errorBeacon":"bam.nr-data.net","agent":""}</script></body> </html>

CINXE.COM

Type I Interferon Signaling Pathways