CINXE.COM

<!DOCTYPE html><html lang="en"><head><script src="https://www.googletagmanager.com/gtag/js?id=G-5JMGYPWJRR" async></script><script>//- global rcsb-config object var RC = { googleAnalyticsTrackingId: 'UA-3923365-3' , instance: 'production' , isProductionServer: true , dataUrl: 'https://data.rcsb.org/' , searchUrl: 'https://search.rcsb.org/rcsbsearch/v2/' , alignmentHost: 'https://alignment.rcsb.org' , alignmentUrl: 'https://alignment.rcsb.org/api/v1/' , fileStorageUrl: 'https://user-upload.rcsb.org/v1/' , fileStoragePutEndpoint: 'putMultipart' , fileStorageGetEndpoint: 'download' , sequenceCoordinatesUrl: 'https://1d-coordinates.rcsb.org/' , internalAnalyticsOriginHeaderKey: 'Rcsb-Analytics-Traffic-Origin' , internalAnalyticsOriginHeaderValue: 'internal' , internalAnalyticsStageHeaderKey: 'Rcsb-Analytics-Traffic-Stage' , internalAnalyticsStageHeaderValue: 'production' , MOLSTAR_IMG_URL: 'https://cdn.rcsb.org/images/structures/' }; </script><script src="/search/search-data?ts=5801809"></script><script src="/js/search/react-search.js?ts=5801809"></script><script>!function(){if("performance"in window==0&&(window.performance={}),Date.now=Date.now||function(){return(new Date).getTime()},"now"in window.performance==0){var n=Date.now();performance.timing&&performance.timing.navigationStart&&(n=performance.timing.navigationStart),window.performance.now=function(){return Date.now()-n}}}();(function(){var h="undefined"!=typeof window&&window===this?this:"undefined"!=typeof global&&null!=global?global:this,k="function"==typeof Object.defineProperties?Object.defineProperty:function(a,b,c){a!=Array.prototype&&a!=Object.prototype&&(a[b]=c.value)};function l(){l=function(){};h.Symbol||(h.Symbol=m)}var n=0;function m(a){return"jscomp_symbol_"+(a||"")+n++} function p(){l();var a=h.Symbol.iterator;a||(a=h.Symbol.iterator=h.Symbol("iterator"));"function"!=typeof Array.prototype[a]&&k(Array.prototype,a,{configurable:!0,writable:!0,value:function(){return q(this)}});p=function(){}}function q(a){var b=0;return r(function(){return b<a.length?{done:!1,value:a[b++]}:{done:!0}})}function r(a){p();a={next:a};a[h.Symbol.iterator]=function(){return this};return a}function t(a){p();var b=a[Symbol.iterator];return b?b.call(a):q(a)} function u(a){if(!(a instanceof Array)){a=t(a);for(var b,c=[];!(b=a.next()).done;)c.push(b.value);a=c}return a}var v=0;function w(a,b){var c=XMLHttpRequest.prototype.send,d=v++;XMLHttpRequest.prototype.send=function(f){for(var e=[],g=0;g<arguments.length;++g)e[g-0]=arguments[g];var E=this;a(d);this.addEventListener("readystatechange",function(){4===E.readyState&&b(d)});return c.apply(this,e)}} function x(a,b){var c=fetch;fetch=function(d){for(var f=[],e=0;e<arguments.length;++e)f[e-0]=arguments[e];return new Promise(function(d,e){var g=v++;a(g);c.apply(null,[].concat(u(f))).then(function(a){b(g);d(a)},function(a){b(a);e(a)})})}}var y="img script iframe link audio video source".split(" ");function z(a,b){a=t(a);for(var c=a.next();!c.done;c=a.next())if(c=c.value,b.includes(c.nodeName.toLowerCase())||z(c.children,b))return!0;return!1} function A(a){var b=new MutationObserver(function(c){c=t(c);for(var b=c.next();!b.done;b=c.next())b=b.value,"childList"==b.type&&z(b.addedNodes,y)?a(b):"attributes"==b.type&&y.includes(b.target.tagName.toLowerCase())&&a(b)});b.observe(document,{attributes:!0,childList:!0,subtree:!0,attributeFilter:["href","src"]});return b} function B(a,b){if(2<a.length)return performance.now();var c=[];b=t(b);for(var d=b.next();!d.done;d=b.next())d=d.value,c.push({timestamp:d.start,type:"requestStart"}),c.push({timestamp:d.end,type:"requestEnd"});b=t(a);for(d=b.next();!d.done;d=b.next())c.push({timestamp:d.value,type:"requestStart"});c.sort(function(a,b){return a.timestamp-b.timestamp});a=a.length;for(b=c.length-1;0<=b;b--)switch(d=c[b],d.type){case "requestStart":a--;break;case "requestEnd":a++;if(2<a)return d.timestamp;break;default:throw Error("Internal Error: This should never happen"); }return 0}function C(a){a=a?a:{};this.w=!!a.useMutationObserver;this.u=a.minValue||null;a=window.__tti&&window.__tti.e;var b=window.__tti&&window.__tti.o;this.a=a?a.map(function(a){return{start:a.startTime,end:a.startTime+a.duration}}):[];b&&b.disconnect();this.b=[];this.f=new Map;this.j=null;this.v=-Infinity;this.i=!1;this.h=this.c=this.s=null;w(this.m.bind(this),this.l.bind(this));x(this.m.bind(this),this.l.bind(this));D(this);this.w&&(this.h=A(this.B.bind(this)))} C.prototype.getFirstConsistentlyInteractive=function(){var a=this;return new Promise(function(b){a.s=b;"complete"==document.readyState?F(a):window.addEventListener("load",function(){F(a)})})};function F(a){a.i=!0;var b=0<a.a.length?a.a[a.a.length-1].end:0,c=B(a.g,a.b);G(a,Math.max(c+5E3,b))} function G(a,b){!a.i||a.v>b||(clearTimeout(a.j),a.j=setTimeout(function(){var b=performance.timing.navigationStart,d=B(a.g,a.b),b=(window.a&&window.a.A?1E3*window.a.A().C-b:0)||performance.timing.domContentLoadedEventEnd-b;if(a.u)var f=a.u;else performance.timing.domContentLoadedEventEnd?(f=performance.timing,f=f.domContentLoadedEventEnd-f.navigationStart):f=null;var e=performance.now();null===f&&G(a,Math.max(d+5E3,e+1E3));var g=a.a;5E3>e-d?d=null:(d=g.length?g[g.length-1].end:b,d=5E3>e-d?null:Math.max(d, f));d&&(a.s(d),clearTimeout(a.j),a.i=!1,a.c&&a.c.disconnect(),a.h&&a.h.disconnect());G(a,performance.now()+1E3)},b-performance.now()),a.v=b)} function D(a){a.c=new PerformanceObserver(function(b){b=t(b.getEntries());for(var c=b.next();!c.done;c=b.next())if(c=c.value,"resource"===c.entryType&&(a.b.push({start:c.fetchStart,end:c.responseEnd}),G(a,B(a.g,a.b)+5E3)),"longtask"===c.entryType){var d=c.startTime+c.duration;a.a.push({start:c.startTime,end:d});G(a,d+5E3)}});a.c.observe({entryTypes:["longtask","resource"]})}C.prototype.m=function(a){this.f.set(a,performance.now())};C.prototype.l=function(a){this.f.delete(a)}; C.prototype.B=function(){G(this,performance.now()+5E3)};h.Object.defineProperties(C.prototype,{g:{configurable:!0,enumerable:!0,get:function(){return[].concat(u(this.f.values()))}}});var H={getFirstConsistentlyInteractive:function(a){a=a?a:{};return"PerformanceLongTaskTiming"in window?(new C(a)).getFirstConsistentlyInteractive():Promise.resolve(null)}}; "undefined"!=typeof module&&module.exports?module.exports=H:"function"===typeof define&&define.amd?define("ttiPolyfill",[],function(){return H}):window.ttiPolyfill=H;})();function gtag(){dataLayer.push(arguments)}var logger=function(){"use strict";function n(n){if(n=JSON.stringify(n),"sendBeacon"in navigator)navigator.sendBeacon(t,n);else{var e=new XMLHttpRequest;e.open("POST",t,!1),e.setRequestHeader("Content-Type","text/plain;charset=UTF-8"),e.send(n)}}function e(e,t,i){if(!RC.isProductionServer)switch(e){case"error":case"warn":case"info":i?console[e](t,i):console[e](t);break;default:console.log(t,i)}"error"!==e&&"warn"!==e||(r.push({level:e,msg:t||"",info:Object.assign({},i,{path:window.location.pathname,userAgent:navigator.userAgent})}),r.length>=o&&n(r.splice(0,o)))}var t="/analytics",o=10,r=[];return window.addEventListener("unload",function(){n(r)},!1),{stack:Function.prototype.bind.call(function(n){n&&e("error",n.name+': "'+n.message+'"',{type:n.name,description:n.message,trace:n.stack})}),error:Function.prototype.bind.call(function(n,t){e("error",n,t)}),warn:Function.prototype.bind.call(function(n,t){e("warn",n,t)}),info:Function.prototype.bind.call(function(n,t){e("info",n,t)}),verbose:Function.prototype.bind.call(function(n,t){e("verbose",n,t)}),debug:Function.prototype.bind.call(function(n,t){e("debug",n,t)}),silly:Function.prototype.bind.call(function(n,t){e("silly",n,t)})}}();window.dataLayer=window.dataLayer||[],gtag("js",new Date),gtag("config","G-5JMGYPWJRR"),window.addEventListener("error",function(n){logger.stack(n.error)}),window.addEventListener("unhandledrejection",function(n){n&&n.reason&&logger.error('Unhandled promise rejection: "'+n.reason.message+'"',{type:"PromiseRejection",description:n.reason.message,trace:n.reason.stack})});var gtagFirstMeaningfulPaint=function(){var n=!1;return function(){n?logger.warn('Timing for "firstMeaningfulPaint" already sent'):(console.log("firstMeaningfulPaint",Math.round(performance.now())),n=!0)}}();!function(){"use strict";var n=0;if("PerformanceObserver"in window&&"PerformancePaintTiming"in window){new PerformanceObserver(function(e){e.getEntries().forEach(function(e){if(0===n){e.startTime,e.duration}})}).observe({entryTypes:["paint"]});var e=window.__tti={e:[]};e.o=new PerformanceObserver(function(n){e.e=e.e.concat(n.getEntries())}),e.o.observe({entryTypes:["longtask"]}),ttiPolyfill.getFirstConsistentlyInteractive({}).then(function(n){});new PerformanceObserver(function(n){n.getEntries().forEach(function(n){var e=n.attribution[0]||{},t={containerType:e.containerType,containerName:e.containerName,containerId:e.containerId,containerSrc:e.containerSrc,frameOrigin:n.name,durationMs:n.duration,startTimeMs:n.startTime};n.duration>500&&logger.warn("Long running task, duration "+n.duration.toFixed(2)+"ms.",t)})}).observe({entryTypes:["longtask"]})}var t=performance.now();window.addEventListener("visibilitychange",function(){document.hidden?t=performance.now():n+=performance.now()-t}),window.addEventListener("load",function(){performance.now()}),window.addEventListener("DOMContentLoaded",function(){performance.now()})}();</script><title>Group Summary Pages</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta property="og:title" content="Group Summary Pages"><meta property="og:description" content="As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists."><meta property="og:image" content="https://cdn.rcsb.org/rcsb-pdb/v2/common/images/rcsb_logo2.png"><meta name="twitter:card" content="summary_large_image"><meta name="twitter:title" content="Group Summary Pages"><meta name="twitter:description" content="As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists."><meta name="twitter:image" content="https://cdn.rcsb.org/rcsb-pdb/v2/common/images/rcsb_logo2.png"><meta name="description" content="As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists."><meta name="author" content="RCSB Protein Data Bank"><meta name="email" content="info@rcsb.org"><meta name="Charset" content="UTF-8"><meta name="Distribution" content="Global"><meta name="Rating" content="General"><meta http-equiv="content-language" content="en-US"><meta name="viewport" content="width=device-width, initial-scale=1"><meta name="theme-color" content="#5e94c3"><meta class="elastic" name="release_date" content="release.date:undef"><link rel="manifest" href="/manifest.json"><link rel="apple-touch-icon" href="/img/rcsb-apple-touch-icon.jpg"><link rel="stylesheet" href="https://cdn.rcsb.org/javascript/bootstrap/latest/css/bootstrap.min.css"><link rel="stylesheet" href="https://cdn.rcsb.org/javascript/fontawesome/latest/css/font-awesome.min.css"><link rel="stylesheet" href="/build/css/main.css"><link rel="stylesheet" href="/css/search.css?ts=5801809"><script>window.addEventListener('load', function () { // load the JIRA feedback button only after everything else has been loaded var script = document.createElement("script"); script.src = "/js/jira-fdbck.js"; script.type = "text/javascript"; document.getElementsByTagName("head")[0].appendChild(script); var link = document.createElement("link"); link.rel = "stylesheet"; link.href = "https://cdn.rcsb.org/jira-feedback/css/jira-fdbck.css"; document.getElementsByTagName("head")[0].appendChild(link); // load the ekko-lightbox css only after everything else has been loaded var link = document.createElement("link"); link.rel = "stylesheet"; link.href = "/css/ekko-lightbox.css"; document.getElementsByTagName("head")[0].appendChild(link); }); </script><script src="https://cdn.rcsb.org/javascript/jquery/jquery-3.3.1.min.js"></script><script src="https://cdn.rcsb.org/javascript/bootstrap/latest/js/bootstrap.min.js"></script><script src="/js/ekko-lightbox.min.js" defer></script><script>$(document).delegate('*[data-toggle="lightbox"]',"click",function(t){t.preventDefault(),$(this).ekkoLightbox()});$(function(){$(".nav>.dropdown").on("mouseenter",function(o){$(this).addClass("open")}),$(".nav>.dropdown").on("mouseleave",function(o){$(".dropdown").removeClass("open")}),$('[data-toggle="tooltip"]').tooltip()});</script></head><body><div data-elastic-exclude><div data-elastic-exclude><nav class="navbar navbar-inverse navbar-fixed-top hidden-print" id="nav" role="navigation"><div class="hide hidden-print" id="UnsupportedBrowser" style="width: 100%; border-bottom: 2px solid #FFA500; background-color: #FFFFFF; color: #000000; display: inline-block; font-size: .9em; line-height: 2em; text-align: center; font-weight: bold; font-style: italic;"><span class="label label-warning" style="font-size: 100%;">Warning</span> You are using a web browser that we do not support. Our website will not work properly. Please update to a newer version or download a new web browser, such as Chrome or Firefox.</div><div class="container"><div class="row pull-right"><div class="col-sm-12"><div class="input-group"> <a class="button btn btn-sm basic navbar-buttons" href="/help">Help</a><div class="button btn btn-sm basic jira-fdbck-btn navbar-buttons" id="feedbackLink-ContactUs">Contact us</div><div class="navbar-buttons hidden-xs mypdb-style" id="mypdb-menu-container"></div></div></div></div><div class="navbar-header"><button class="navbar-toggle pull-left" type="button" data-toggle="collapse" data-target="#navbar-collapse-RCSB"><span class="sr-only">Toggle navigation</span><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button><a class="navbar-brand" href="/">RCSB PDB</a></div><div class="collapse navbar-collapse" id="navbar-collapse-RCSB" style="max-height: 420px;"><ul class="nav navbar-nav pull-left"><li class="dropdown" id="headnav_deposit"><a class="dropdown-toggle" href="#" data-toggle="dropdown" aria-expanded="false">Deposit <b class="caret"></b></a><div class="dropdown-menu multi-column" id="DepositDropdownNav"><div class="row"><div class="col-xs-12 col-sm-12 col-md-2"><ul class="dropdown-menu" id="head-deposit_prepare"><h4>Prepare Data</h4><li> <a href="https://www.wwpdb.org/deposition/preparing-pdbx-mmcif-files" rel="noopener" target="_blank">PDBx/mmCIF file</a></li><li> <a href="https://pdb-extract.wwpdb.org/" rel="noopener" target="_blank">pdb_extract</a></li><li> <a href="http://sf-tool.wwpdb.org/" rel="noopener" target="_blank">SF-Tool</a></li><li> <a href="http://ligand-expo.rcsb.org/" rel="noopener" target="_blank">Ligand Expo</a></li><li> <a href="https://sw-tools.rcsb.org/apps/MAXIT/index.html" rel="noopener" target="_blank">MAXIT</a></li></ul></div><div class="col-xs-12 col-sm-12 col-md-3"><ul class="dropdown-menu" id="head-deposit_validate"><h4>Validate Data</h4><li> <a href="https://validate-rcsb.wwpdb.org" rel="noopener" target="_blank">Validation Server</a></li><li> <a href="http://www.wwpdb.org/validation/onedep-validation-web-service-interface" rel="noopener" target="_blank">Validation API</a></li><li> <a href="http://www.wwpdb.org/documentation/journals" rel="noopener" target="_blank">Information for Journals</a></li><li> <a href="http://www.wwpdb.org/task/validation-task-forces.php" rel="noopener" target="_blank">Validation Task Forces</a></li></ul></div><div class="col-xs-12 col-sm-12 col-md-3"><ul class="dropdown-menu" id="head-deposit_deposit-data"><h4>Deposit Data</h4><li style="word-break: normal"> <a href="https://deposit.wwpdb.org/deposition/" rel="noopener" target="_blank" style="word-break: normal">wwPDB OneDep System</a></li><li style="word-break: normal"> <a href="https://data.pdb-ihm.org/" rel="noopener" target="_blank" style="word-break: normal">PDB-IHM</a></li></ul></div><div class="col-xs-12 col-sm-12 col-md-3"><ul class="dropdown-menu" id="head-deposit_deposit-help"><h4>Help and Resources</h4><li> <a href="http://www.wwpdb.org/deposition/faq" rel="noopener" target="_blank">Deposit FAQ</a></li><li> <a href="http://www.wwpdb.org/validation/2017/FAQs" rel="noopener" target="_blank">Validation FAQ</a></li><li> <a href="http://www.wwpdb.org/deposition/tutorial" rel="noopener" target="_blank">Tutorials</a></li><li> <a href="http://www.wwpdb.org/documentation/policy" rel="noopener" target="_blank">Annotation Policies</a></li><li> <a href="http://www.wwpdb.org/documentation/procedure" rel="noopener" target="_blank">Processing Procedures</a></li><li> <a href="https://mmcif.wwpdb.org/" rel="noopener" target="_blank">PDBx/mmCIF Dictionary</a></li><li> <a href="https://mmcif.wwpdb.org/docs/user-guide/guide.html" rel="noopener" target="_blank">PDBx/mmCIF User Guide</a></li><li> <a href="https://www.wwpdb.org/data/ccd" rel="noopener" target="_blank">Chemical Component Dictionary</a></li><li> <a href="https://www.wwpdb.org/data/bird" rel="noopener" target="_blank">Biologically Interesting Molecule Reference Dictionary (BIRD)</a></li><li> <a href="https://biosync.sbkb.org/" rel="noopener" target="_blank">BioSync/Beamlines/Facilities</a></li><li> <a href="https://sw-tools.rcsb.org/" rel="noopener" target="_blank">Related Tools</a></li></ul></div></div></div></li><li class="dropdown" id="headnav_search"><a class="dropdown-toggle" href="#" data-toggle="dropdown">Search <b class="caret"></b></a><ul class="dropdown-menu"><li><a href="/search/advanced" rel="noopener">Advanced Search</a></li><li><a href="/search/advanced/sequence" rel="noopener">Sequence Similarity Search</a></li><li><a href="/search/advanced/structure" rel="noopener">Structure Similarity Search</a></li><li><a href="/search/advanced/chemical" rel="noopener">Chemical Similarity Search</a></li><li><a href="/chemical-sketch" rel="noopener">Chemical Sketch Tool</a></li><li><a href="/search/browse/atc" rel="noopener">Browse by Annotations</a></li><li><a href="/search?query=%7B%22parameters%22%3A%7B%22attribute%22%3A%22rcsb_accession_info.initial_release_date%22%2C%22operator%22%3A%22range%22%2C%22value%22%3A%7B%22from%22%3A%22now-1w%22%2C%22include_lower%22%3Afalse%2C%22to%22%3A%22now%22%2C%22include_upper%22%3Atrue%7D%7D%7D" rel="noopener">New Entries</a></li><li><a href="/pages/unreleased" rel="noopener">Unreleased Entries</a></li><li><a href="/stats" rel="noopener">PDB Statistics</a></li></ul></li><li class="dropdown" id="headnav_visualize"><a class="dropdown-toggle" href="#" data-toggle="dropdown">Visualize <b class="caret"></b></a><ul class="dropdown-menu"> <li><a href="/3d-view" rel="noopener">Mol* (MolStar)</a></li><li><a href="/docs/sequence-viewers/sequence-annotations-viewer" rel="noopener">Sequence Annotations Viewer</a></li><li><a href="/docs/sequence-viewers/genome-view" rel="noopener">Genome View</a></li></ul></li><li class="dropdown" id="headnav_analyze"><a class="dropdown-toggle" href="#" data-toggle="dropdown">Analyze <b class="caret"></b></a><ul class="dropdown-menu"><li><a href="/alignment" rel="noopener">Pairwise Structure Alignment</a></li><li><a href="/docs/general-help/symmetry-resources-in-the-pdb" rel="noopener">Symmetry Resources in the PDB</a></li><li><a href="https://www.wwpdb.org/validation/validation-reports" rel="noopener" target="_blank">Structure Quality </a></li><li><a href="/docs/grouping-structures/overview-grouping-structures" rel="noopener">Grouping Structures</a></li><li><a href="https://cdn.rcsb.org/rcsb-pdb/pdb50mesh/index.html" rel="noopener" target="_blank">PDB Citation MeSH Network Explorer </a></li><li><a href="/stats" rel="noopener">PDB Statistics</a></li><li><a href="https://www.eppic-web.org" rel="noopener" target="_blank">EPPIC Biological Assemblies </a></li><li class="extraList">External Data and Resources </li><li class="extraMargin"><a href="/docs/general-help/data-from-external-resources-integrated-into-rcsb-pdb" rel="noopener">Integrated Resources </a></li><li class="extraMargin"><a href="/docs/additional-resources/databases-and-knowledgebases" rel="noopener">Additional Resources </a></li></ul></li><li class="dropdown hidden-xs hidden-sm" id="headnav_download"><a class="dropdown-toggle" href="#" data-toggle="dropdown">Download <b class="caret"></b></a><ul class="dropdown-menu"> <li><a href="/downloads" rel="noopener">Coordinates and Experimental Data</a></li><li><a href="/downloads/fasta" rel="noopener">Sequences</a></li><li><a href="/downloads/ligands" rel="noopener">Ligands</a></li><li><a href="/docs/programmatic-access/file-download-services" rel="noopener">File Download Services</a></li><li><a href="/docs/programmatic-access/web-apis-overview" rel="noopener">Web APIs</a></li></ul></li><li class="dropdown" id="headnav_learn"><a class="dropdown-toggle" href="#" data-toggle="dropdown">Learn <b class="caret"></b></a><ul class="dropdown-menu"><h4><a href="http://pdb101.rcsb.org" target="_blank" rel="noopener"><img class="image_submenu" src="https://cdn.rcsb.org/rcsb-pdb/v2/home/images/menuImgs/pdb101Logo.png"></a></h4><li><a href="https://pdb101.rcsb.org/train/training-events" rel="noopener" target="_blank">Training Courses </a></li><li><a href="https://pdb101.rcsb.org/learn/guide-to-understanding-pdb-data/introduction" rel="noopener" target="_blank">Guide to PDB Data </a></li><li><a href="https://pdb101.rcsb.org/motm/motm-by-date" rel="noopener" target="_blank">Molecule of the Month </a></li><li><a href="https://pdb101.rcsb.org/learn/paper-models" rel="noopener" target="_blank">Educational Resources </a></li><li><a href="https://pdb101.rcsb.org/teach/overview" rel="noopener" target="_blank">Curricula </a></li><li><a href="https://pdb101.rcsb.org/browse" rel="noopener" target="_blank">Browse </a></li><li><a href="https://pdb101.rcsb.org/news/2023" rel="noopener" target="_blank">News </a></li><li class="extraList">SciArt Galleries </li><li class="extraMargin"><a href="https://pdb101.rcsb.org/sci-art/geis-archive/gallery-by-name" rel="noopener" target="blank">Irving Geis </a></li><li class="extraMargin"><a href="https://pdb101.rcsb.org/sci-art/goodsell-gallery" rel="noopener" target="blank">David Goodsell </a></li></ul></li><li class="dropdown" id="headnav_more"><a class="dropdown-toggle" href="#" data-toggle="dropdown">About <b class="caret"></b></a><ul class="dropdown-menu"><li><a href="/pages/contactus" rel="noopener">Contact Us</a></li><li><a href="/pages/about-us/index" rel="noopener">About RCSB PDB</a></li><li><a href="/pages/about-us/mission" rel="noopener">Vision and Mission</a></li><li><a href="/pages/policies" rel="noopener">Citation, Usage, Privacy Policies, Logo</a></li><li><a href="/pages/news" rel="noopener">News</a></li><li><a href="/pages/about-us/history" rel="noopener">PDB History</a></li><li><a href="/pages/pdb50" rel="noopener">PDB50</a></li><li><a href="/pages/about-us/pdb-user-community" rel="noopener">User Community</a></li><li><a href="/pages/publications" rel="noopener">Publications</a></li><li><a href="/pages/advisory-committee" rel="noopener">RCSB PDB Advisory Committee</a></li><li><a href="/pages/team" rel="noopener">Team Members</a></li><li><a href="/pages/about-us/deia" rel="noopener">Diversity, Equity, Inclusion, and Access</a></li><li><a href="https://status.rcsb.org/" rel="noopener" target="_blank">Service Status </a></li></ul></li><li class="nodropdown"><a class="dropdown-toggle" href="/pages/jobs">Careers</a></li><li class="nodropdown"><a class="dropdown-toggle" href="/news/feature/5e74d55d2d410731e9944f52">COVID-19</a></li><li class="dropdown visible-xs"><div id="socialmedia_section_mobile"><ul class="fa-ul hidden-print"><li><a href="https://www.facebook.com/RCSBPDB" target="_blank" rel="noopener" title="Facebook" data-placement="top" data-toggle="tooltip"><i class="fa fa-facebook-square fa-lg"></i></a></li><li><a href="https://twitter.com/buildmodels" target="_blank" rel="noopener" title="Twitter" data-placement="top" data-toggle="tooltip"><i class="fa fa-twitter fa-lg"></i></a></li><li><a href="https://www.youtube.com/user/RCSBProteinDataBank" target="_blank" rel="noopener" title="YouTube" data-placement="top" data-toggle="tooltip"><i class="fa fa-youtube-play fa-lg"></i></a></li><li><a href="https://github.com/rcsb" target="_blank" rel="noopener" title="Github" data-placement="top" data-toggle="tooltip"><i class="fa fa-github fa-lg"></i></a></li><li><a href="https://www.linkedin.com/company/rcsb-protein-data-bank" target="_blank" rel="noopener" title="LinkedIn" data-placement="top" data-toggle="tooltip"><i class="fa fa-linkedin fa-lg"></i></a></li></ul></div></li></ul></div></div></nav></div><style>#PDBmembers li {margin-right: 15px; } </style><div data-elastic-exclude><div id="header"><div class="container"><div class="row" style="margin-bottom: 0px;"><div class="col-md-6 col-lg-5 hidden-sm hidden-xs" id="logo_container" style="padding-bottom: 15px;"><table class="header-left"><tr><td><a href="/"><img id="rcsblogo" src="https://cdn.rcsb.org/rcsb-pdb/v2/common/images/rcsb_logo.png" alt="RCSB PDB"></a></td><td><table id="header-counts"><tr><td><div class="results-content-type-sm experimental"><span class="fa fa-flask" data-toggle="tooltip" data-placement="right" data-original-title="Experimental PDB Structure"></span></div></td><td><a href="/search?request=%7B%22query%22%3A%7B%22type%22%3A%22group%22%2C%22nodes%22%3A%5B%7B%22type%22%3A%22group%22%2C%22nodes%22%3A%5B%7B%22type%22%3A%22group%22%2C%22nodes%22%3A%5B%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22text%22%2C%22parameters%22%3A%7B%22attribute%22%3A%22rcsb_entry_info.structure_determination_methodology%22%2C%22operator%22%3A%22exact_match%22%2C%22value%22%3A%22experimental%22%7D%7D%5D%2C%22logical_operator%22%3A%22and%22%7D%5D%2C%22logical_operator%22%3A%22and%22%2C%22label%22%3A%22text%22%7D%5D%2C%22logical_operator%22%3A%22and%22%7D%2C%22return_type%22%3A%22entry%22%2C%22request_options%22%3A%7B%22scoring_strategy%22%3A%22combined%22%2C%22results_content_type%22%3A%5B%22experimental%22%5D%7D%7D" style="font-weight: bold; font-size: 110%">232,059</a><span> Structures from the PDB</span></td></tr><tr><td><div class="results-content-type-sm computational"><span class="fa fa-desktop" data-toggle="tooltip" data-placement="right" data-original-title="Computed Structure Model"></span></div></td><td><a href="/search?request=%7B%22query%22%3A%7B%22type%22%3A%22group%22%2C%22nodes%22%3A%5B%7B%22type%22%3A%22group%22%2C%22nodes%22%3A%5B%7B%22type%22%3A%22group%22%2C%22nodes%22%3A%5B%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22text%22%2C%22parameters%22%3A%7B%22attribute%22%3A%22rcsb_entry_info.structure_determination_methodology%22%2C%22operator%22%3A%22exact_match%22%2C%22value%22%3A%22computational%22%7D%7D%5D%2C%22logical_operator%22%3A%22and%22%7D%5D%2C%22logical_operator%22%3A%22and%22%2C%22label%22%3A%22text%22%7D%5D%2C%22logical_operator%22%3A%22and%22%7D%2C%22return_type%22%3A%22entry%22%2C%22request_options%22%3A%7B%22scoring_strategy%22%3A%22combined%22%2C%22results_content_type%22%3A%5B%22computational%22%5D%7D%7D" style="font-weight: bold; font-size: 110%">1,068,577</a><span> Computed Structure Models (CSM)</span></td></tr></table></td></tr></table></div><div class="col-sm-12 col-md-6 col-lg-7 hidden-print" id="search-bar-container"></div></div></div><div class="logos_bcg"><div class="container"><ul class="hidden-xs hidden-print" id="PDBmembers"><li><span data-toggle="tooltip" data-placement="right" data-original-title="PDB-101: Training and outreach portal of RCSB PDB"><a href="https://pdb101.rcsb.org/"><img id="pdb101logo" src="https://cdn.rcsb.org/rcsb-pdb/v2/common/images/pdb101-truncated.png" alt="PDB-101"></a></span></li><li><span data-toggle="tooltip" data-placement="right" data-original-title="wwPDB: Worldwide Protein Data Bank"><a href="https://www.wwpdb.org/" target="_blank" rel="noopener"><img id="wwpdblogo" src="https://cdn.rcsb.org/rcsb-pdb/v2/common/images/wwpdb-truncated.png" alt="wwPDB"></a></span></li><li><span data-toggle="tooltip" data-placement="right" data-original-title="EMDataResource: 3DEM resources"><a href="https://www.emdataresource.org" target="_blank" rel="noopener"><img id="emdatabanklogo" src="https://cdn.rcsb.org/rcsb-pdb/v2/common/images/emdb-truncated.png" alt="EMDataResource"></a></span></li><li><span data-toggle="tooltip" data-placement="right" data-original-title="NAKB: Nucleic Acid Knowledgebase"><a href="https://nakb.org/" target="_blank" rel="noopener"><img id="nakblogo" src="https://cdn.rcsb.org/rcsb-pdb/v2/common/images/nakb-logo.png" alt="NAKB: Nucleic Acid Knowledgebase"></a></span></li><li><span data-toggle="tooltip" data-placement="right" data-original-title="wwPDB Foundation: Donate to support wwPDB outreach activities"><a href="https://foundation.wwpdb.org/" target="_blank" rel="noopener"><img id="wwpdbfoundationlogo" src="https://cdn.rcsb.org/rcsb-pdb/v2/common/images/foundation-truncated.png" alt="wwPDB Foundation"></a></span></li><li><span data-toggle="tooltip" data-placement="right" data-original-title="PDB-IHM: System for Archiving Integrative Structures"><a href="https://pdb-ihm.org/" target="_blank" rel="noopener"><img id="pdbdevlogo" src="https://cdn.rcsb.org/rcsb-pdb/v2/common/images/pdb-ihm-logo.png" alt="PDB-IHM Logo"></a></span></li></ul><div id="socialmedia_section"><ul class="fa-ul hidden-print"><li><a href="https://www.facebook.com/RCSBPDB" target="_blank" rel="noopener" title="Facebook" data-placement="top" data-toggle="tooltip"><i class="fa fa-facebook-square fa-lg"></i></a></li><li><a href="https://twitter.com/buildmodels" target="_blank" rel="noopener" title="Twitter" data-placement="top" data-toggle="tooltip"><i class="fa fa-twitter fa-lg"></i></a></li><li><a href="https://www.youtube.com/user/RCSBProteinDataBank" target="_blank" rel="noopener" title="YouTube" data-placement="top" data-toggle="tooltip"><i class="fa fa-youtube-play fa-lg"></i></a></li><li><a href="https://github.com/rcsb" target="_blank" rel="noopener" title="Github" data-placement="top" data-toggle="tooltip"><i class="fa fa-github fa-lg"></i></a></li><li><a href="https://www.linkedin.com/company/rcsb-protein-data-bank" target="_blank" rel="noopener" title="LinkedIn" data-placement="top" data-toggle="tooltip"><i class="fa fa-linkedin fa-lg"></i></a></li></ul></div></div></div></div></div><div class="container" id="maincontentcontainer"><style>p {font-size: 16px} ul li {font-size: 16px} div#docs-container { margin: 0; } span.glyphicon-new-window { font-size: 10px; } div .main-heading h1{ margin-top: 0; } div#helpmenu .small-menu { text-align: right; white-space: nowrap; /* Prevent text wrapping */ } div#helpmenu .small-menu p{ font-size: 15px; } div#helpmenu .small-menu a{ color: #325880; } div#helpmenu .divider { color: #5E5D5D; padding: 0 8px; } /* menu */ div#menu { border-bottom: 1px solid #ddd; } div#menu a { text-decoration: none; } div#menu-header { border-top: 1px solid #ddd; padding: 4px; } div.group { background-color: #f9f9f9; cursor: pointer; border-top: 1px solid #ddd; padding: 4px 0; } div.group table, div.group td:first-child, div.item table, div.item td:first-child { width: 100%; } div.item td { color: #337ab7; border-top: 1px solid #ddd; padding: 4px; } span.glyphicon-triangle-top, span.glyphicon-triangle-bottom { font-size: 8px; color: #666; } span.glyphicon-chevron-right { font-size: 10px; color: #337ab7; } /* add media query for mobile view */ @media (max-width: 768px) { /* optionally hide toggle icons on mobile */ span.glyphicon-triangle-top, span.glyphicon-triangle-bottom { display: none; } } /* item */ h5.menu-path { color: #666; } /* note: css defined here needs to be in sync with CMS Editor - TODO create a shared file on the CDN? */ a.content-anchor { display: block; position: relative; visibility: hidden; top: -60px; } table.content-resources { width: 100%; border-collapse: collapse; } table.content-resources td { border: 1px solid #ddd; vertical-align: top; padding: 5px; } td.content-img-caption { font-size: 16px; font-style: italic; padding: 5px 0; } img.content-img-border { border: 1px solid #ccc; } div.item-info { font-style: italic; font-size: 16px; color: #888; } div.ekko-lightbox div.modal-dialog { width: auto; max-width: 1170px; } </style><script>// groupMap passed from routes/docs.js var groupMap = {"5fca9f91eb210c2c564f0d7c":{"_id":"5fca9f91eb210c2c564f0d7c","depth":0,"name":"General Help","parent_id":"5fd18dfceb210c2c5634aead","type":"group","_ids":["5fc537b03fb4b83beba83b23","5fc51a863fb4b83beb6e959f","63002035b05c2fccc1804d67","62d9b56b35ec5bb4ddb19a42","6003401bcff89d5fc8f8a3f3","6140b307ef055f03d1f222d2","60b686d701b8e50720f2ca63","6018251aecb9a74be53123a7","5fce4e38eb210c2c56790636","5fce5135eb210c2c567d7ab2","600756cec5ab5836659ab2e5","60ebb04e0882a5597783cc03","6080bf66ec901916050494bd","6005be80cff89d5fc8f8a3f5","5ff90b5af32c497fd6f7bf62","67224602e095838a1ce7d99f"],"show":true},"5fbe8e183fb4b83beb4d0e39":{"_id":"5fbe8e183fb4b83beb4d0e39","depth":0,"name":"Search and Browse","parent_id":"5fd18dfceb210c2c5634aead","type":"group","_ids":["60006df7ae9f8477226a6c82","5ffde6ee3a38a923c3516cf2","60083954244a4309df45ad46","602c55d11a359e6e2d4a6ea7","6000bab4d3c1ff0cf1f44f48"],"show":true},"60083954244a4309df45ad46":{"_id":"60083954244a4309df45ad46","depth":1,"name":"Advanced Search","parent_id":"5fbe8e183fb4b83beb4d0e39","type":"group","_ids":["5ffde93f3a38a923c3516cf3","5fbecb613fb4b83bebb5e353","600b08bec5ab5836659ab2e9","5ffde9d03a38a923c3516cf5","5ffdeaf53a38a923c3516cf6","5ffe9c743a38a923c3516cfb","600b3277c5ab5836659ab2ea","5ffe9da13a38a923c3516cfc","602c2b653fed9e549afd7917","600061f0ae9f8477226a6c81"]},"602c55d11a359e6e2d4a6ea7":{"_id":"602c55d11a359e6e2d4a6ea7","depth":1,"name":"Browse Options","parent_id":"5fbe8e183fb4b83beb4d0e39","type":"group","_ids":["602c53f43fed9e549afd7918","602c56893fed9e549afd791a","602c56b23fed9e549afd791b","646f8b661d621d75127a7a53","602c57773fed9e549afd791f","602c59ab3fed9e549afd7922","65d93e6f72841524659883e1","61410115ef055f03d1f222d3","602c59da3fed9e549afd7923","602c59f53fed9e549afd7924","602c57cf3fed9e549afd7921","6080adaaec901916050494bc","602c57ae3fed9e549afd7920","602c5a1e3fed9e549afd7925","602c57133fed9e549afd791d","602c57603fed9e549afd791e","6141014def055f03d1f222d4","602c56f13fed9e549afd791c"]},"618271c92a7d828464a7d146":{"_id":"618271c92a7d828464a7d146","depth":0,"name":"Exploring a 3D Structure","parent_id":"5fd18dfceb210c2c5634aead","type":"group","_ids":["618274c904fb9835c6ae189a","618271f904fb9835c6ae1892","6182729704fb9835c6ae1893","618272c004fb9835c6ae1894","618272e004fb9835c6ae1895","618272fb04fb9835c6ae1896","6182730904fb9835c6ae1897","6182731a04fb9835c6ae1898","6182732a04fb9835c6ae1899"],"show":true},"5fd3e3a6eb210c2c5632d098":{"_id":"5fd3e3a6eb210c2c5632d098","depth":0,"name":"3D Viewers","parent_id":"5fd18dfceb210c2c5634aead","type":"group","_ids":["5f98cc9614cc37a34de620ea","60075352c5ab5836659ab2e3","65a4b499c76ca3abcc925d0d"],"show":true},"5f98cc9614cc37a34de620ea":{"_id":"5f98cc9614cc37a34de620ea","depth":1,"name":"Mol*","parent_id":"5fd3e3a6eb210c2c5632d098","type":"group","_ids":["5ee0fc4d25aa7b208a9fe39e","5ee107b225aa7b208a9fe3a1","5ee10ad725aa7b208a9fe3a2","5ee1046625aa7b208a9fe3a0","5ee1192f25aa7b208a9fe3a3","5ee13ac17f50f44e6aa4fb1f","5ee231607f50f44e6aa4fb20","5ee253237f50f44e6aa4fb22"]},"6256b2b3b4396e45e97bf3de":{"_id":"6256b2b3b4396e45e97bf3de","depth":0,"name":"Grouping Structures","parent_id":"5fd18dfceb210c2c5634aead","type":"group","_ids":["62fbafaf3b6e49562fa5c055","6081c10aec901916050494be","6256b3269c3931864b07285b","6256b35e9c3931864b07285c","6364336066d6046810db7f11"],"show":true,"open":true},"5fd3e3f4eb210c2c56332c65":{"_id":"5fd3e3f4eb210c2c56332c65","depth":0,"name":"Sequence Viewers","parent_id":"5fd18dfceb210c2c5634aead","type":"group","_ids":["60103d1ab1afe64903398251","60342ff52087e87def0d0b09","5fc7f2843fb4b83beb6a7a3d","60182dc1ecb9a74be53123aa"],"show":true},"60132e62aeeea33d3f095fa8":{"_id":"60132e62aeeea33d3f095fa8","depth":0,"name":"Tools","parent_id":"5fd18dfceb210c2c5634aead","type":"group","_ids":["60132e6a610d04019e01d4c2"],"show":true},"600217ee5b6ad53203751b79":{"_id":"600217ee5b6ad53203751b79","depth":0,"name":"Programmatic Access","parent_id":"5fd18dfceb210c2c5634aead","type":"group","_ids":["602d94713fed9e549afd7926","60398336fec59804432bfc37","60183326ecb9a74be53123ab","610337d7ef055f03d1f222b9","60033e6ccff89d5fc8f8a3f2"],"show":true},"601024f3244a4309df5d6630":{"_id":"601024f3244a4309df5d6630","depth":0,"name":"Additional Resources","parent_id":"5fd18dfceb210c2c5634aead","type":"group","_ids":["6010260ee244795fc6dcb836","6010260ee244795fc6dcb839","6010260ee244795fc6dcb838","63ee50cac031758bf1c30ff4","60135c8f236b8b22a9824a4a","6010260ee244795fc6dcb83a","6010260ee244795fc6dcb83d","6010260ee244795fc6dcb83c","60102b1ab1afe6490339824f","6168521eef055f03d1f2231b","6010260ee244795fc6dcb83e","63dc03c2c031758bf1c30ff0","6317770e831916e52206a1ea","6010260ee244795fc6dcb837"],"show":true}} //log(groupMap, 'groupMap') // open/close group function toggle(_id) { var group = groupMap[_id] , _ids = group._ids // list of child _ids of this group , open = (group.open) ? true : false if (open) { closeGroup(group) // close group and all descendants } else { for (var i = 0, n = _ids.length; i < n; i++) $('#' + _ids[i]).removeClass('hidden').addClass('show') group.open = true $('#glyph' + _id).removeClass('glyphicon-triangle-bottom').addClass('glyphicon-triangle-top') } } // recursive function to close all descendants of a group function closeGroup(group) { if (group.open) { var _ids = group._ids // list of child _ids of this group for (var i = 0, n = _ids.length; i < n; i++) { var _id = _ids[i] $('#' + _id).removeClass('show').addClass('hidden') if (groupMap[_id]) closeGroup(groupMap[_id]) // recursive call } group.open = false $('#glyph' + group._id).removeClass('glyphicon-triangle-top').addClass('glyphicon-triangle-bottom') } } // log obj or primitive function log(o, s) { if (!s) s = typeof s if (typeof o === 'object') console.log(s + '=' + JSON.stringify(o, null, 2)) else console.log(s + '=' + o) } // function to close all open groups for mobile view function closeAllGroups() { for (var id in groupMap) { var group = groupMap[id]; if (group.open) { closeGroup(group); // Close the group if it's open } } } // function to check the screen size and close groups on mobile function handleResize() { var isMobileView = window.innerWidth <= 768; // mobile view threshold if (isMobileView) { closeAllGroups(); // close all groups if in mobile view } } // call handleResize on initial load and on window resize window.onload = handleResize; window.onresize = handleResize; </script><div id="docs-container"><div class="row"><div class="col-sm-9 main-heading"><h1>RCSB PDB Help</h1></div><div id="helpmenu"><div class="col-sm-3 small-menu"><p><i class="fa fa-home" aria-hidden="true"></i>&nbsp<a href="/help">Help Topics</a><span class="divider">| </span><i class="fa fa-question-circle" aria-hidden="true"></i>&nbsp<a href="/docs/general-help/website-faq">FAQs</a><span class="divider">| </span><i class="fa fa-book" aria-hidden="true"></i>&nbsp<a href="/docs/general-help/glossary">Glossary</a></p></div></div></div><div class="row"><div class="col-lg-3 col-md-4 col-sm-12 hidden-print"><div data-elastic-exclude><div id="menu"><div id="menu-header">Documentation</div><div class="group show" id="5fca9f91eb210c2c564f0d7c" onclick="toggle("5fca9f91eb210c2c564f0d7c")"><table><tr><td style="padding-left: 4px">General Help</td><td><span class="glyphicon glyphicon-triangle-bottom" id="glyph5fca9f91eb210c2c564f0d7c"></span></td></tr></table></div><div class="item hidden" id="5fc537b03fb4b83beba83b23"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/general-help/organization-of-3d-structures-in-the-protein-data-bank">Organization of 3D Structures in the Protein Data Bank</a></td></tr></table></div><div class="item hidden" id="5fc51a863fb4b83beb6e959f"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/general-help/identifiers-in-pdb">Identifiers in PDB</a></td></tr></table></div><div class="item hidden" id="63002035b05c2fccc1804d67"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/general-help/assessing-the-quality-of-3d-structures">Assessing the Quality of 3D Structures</a></td></tr></table></div><div class="item hidden" id="62d9b56b35ec5bb4ddb19a42"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/general-help/computed-structure-models-and-rcsborg">Computed Structure Models and RCSB.org</a></td></tr></table></div><div class="item hidden" id="6003401bcff89d5fc8f8a3f3"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/general-help/data-from-external-resources-integrated-into-rcsb-pdb">Data From External Resources Integrated Into RCSB PDB</a></td></tr></table></div><div class="item hidden" id="6140b307ef055f03d1f222d2"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/general-help/symmetry-resources-in-the-pdb">Symmetry Resources in the PDB</a></td></tr></table></div><div class="item hidden" id="60b686d701b8e50720f2ca63"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/general-help/ligand-structure-quality-in-pdb-structures">Ligand Structure Quality in PDB Structures</a></td></tr></table></div><div class="item hidden" id="6018251aecb9a74be53123a7"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/general-help/web-services-overview">Web Services Overview</a></td></tr></table></div><div class="item hidden" id="5fce4e38eb210c2c56790636"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/general-help/x-ray-electron-density-maps">X-ray Electron Density Maps</a></td></tr></table></div><div class="item hidden" id="5fce5135eb210c2c567d7ab2"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/general-help/structures-without-legacy-pdb-format-files">Structures Without Legacy PDB Format Files</a></td></tr></table></div><div class="item hidden" id="600756cec5ab5836659ab2e5"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/general-help/deposition-resources">Deposition Resources</a></td></tr></table></div><div class="item hidden" id="60ebb04e0882a5597783cc03"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/general-help/software-supporters">Software Supporters</a></td></tr></table></div><div class="item hidden" id="6080bf66ec901916050494bd"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/general-help/membrane-protein-resources">Membrane Protein Resources</a></td></tr></table></div><div class="item hidden" id="6005be80cff89d5fc8f8a3f5"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/general-help/website-faq">Website FAQ</a></td></tr></table></div><div class="item hidden" id="5ff90b5af32c497fd6f7bf62"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/general-help/glossary">Glossary</a></td></tr></table></div><div class="item hidden" id="67224602e095838a1ce7d99f"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/general-help/help-topics-home">Help Topics Home</a></td></tr></table></div><div class="group show" id="5fbe8e183fb4b83beb4d0e39" onclick="toggle("5fbe8e183fb4b83beb4d0e39")"><table><tr><td style="padding-left: 4px">Search and Browse</td><td><span class="glyphicon glyphicon-triangle-bottom" id="glyph5fbe8e183fb4b83beb4d0e39"></span></td></tr></table></div><div class="item hidden" id="60006df7ae9f8477226a6c82"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/search-and-browse/overview-search-and-browse">Overview: Search and Browse</a></td></tr></table></div><div class="item hidden" id="5ffde6ee3a38a923c3516cf2"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/search-and-browse/basic-search">Basic Search</a></td></tr></table></div><div class="group hidden" id="60083954244a4309df45ad46" onclick="toggle("60083954244a4309df45ad46")"><table><tr><td style="padding-left: 24px">Advanced Search</td><td><span class="glyphicon glyphicon-triangle-bottom" id="glyph60083954244a4309df45ad46"></span></td></tr></table></div><div class="item hidden" id="5ffde93f3a38a923c3516cf3"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/advanced-search/overview-advanced-search">Overview: Advanced Search</a></td></tr></table></div><div class="item hidden" id="5fbecb613fb4b83bebb5e353"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/advanced-search/attribute-search">Attribute Search</a></td></tr></table></div><div class="item hidden" id="600b08bec5ab5836659ab2e9"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/advanced-search/attribute-details">Attribute Details</a></td></tr></table></div><div class="item hidden" id="5ffde9d03a38a923c3516cf5"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/advanced-search/sequence-similarity-search">Sequence Similarity Search</a></td></tr></table></div><div class="item hidden" id="5ffdeaf53a38a923c3516cf6"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/advanced-search/sequence-motif-search">Sequence Motif Search</a></td></tr></table></div><div class="item hidden" id="5ffe9c743a38a923c3516cfb"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/advanced-search/structure-similarity-search">Structure Similarity Search</a></td></tr></table></div><div class="item hidden" id="600b3277c5ab5836659ab2ea"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/advanced-search/structure-motif-search">Structure Motif Search</a></td></tr></table></div><div class="item hidden" id="5ffe9da13a38a923c3516cfc"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/advanced-search/chemical-similarity-search">Chemical Similarity Search</a></td></tr></table></div><div class="item hidden" id="602c2b653fed9e549afd7917"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/advanced-search/chemical-sketch-tool">Chemical Sketch Tool</a></td></tr></table></div><div class="item hidden" id="600061f0ae9f8477226a6c81"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/advanced-search/search-examples">Search Examples</a></td></tr></table></div><div class="group hidden" id="602c55d11a359e6e2d4a6ea7" onclick="toggle("602c55d11a359e6e2d4a6ea7")"><table><tr><td style="padding-left: 24px">Browse Options</td><td><span class="glyphicon glyphicon-triangle-bottom" id="glyph602c55d11a359e6e2d4a6ea7"></span></td></tr></table></div><div class="item hidden" id="602c53f43fed9e549afd7918"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/overview-browse">Overview: Browse</a></td></tr></table></div><div class="item hidden" id="602c56893fed9e549afd791a"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/atc">ATC</a></td></tr></table></div><div class="item hidden" id="602c56b23fed9e549afd791b"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/biological-process">Biological Process</a></td></tr></table></div><div class="item hidden" id="646f8b661d621d75127a7a53"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/card">CARD</a></td></tr></table></div><div class="item hidden" id="602c57773fed9e549afd791f"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/cath">CATH</a></td></tr></table></div><div class="item hidden" id="602c59ab3fed9e549afd7922"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/cellular-component">Cellular Component</a></td></tr></table></div><div class="item hidden" id="65d93e6f72841524659883e1"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/disease-ontology">Disease Ontology</a></td></tr></table></div><div class="item hidden" id="61410115ef055f03d1f222d3"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/ecod">ECOD</a></td></tr></table></div><div class="item hidden" id="602c59da3fed9e549afd7923"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/enzyme-classification">Enzyme Classification</a></td></tr></table></div><div class="item hidden" id="602c59f53fed9e549afd7924"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/genome-location">Genome Location</a></td></tr></table></div><div class="item hidden" id="602c57cf3fed9e549afd7921"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/mesh">MeSH</a></td></tr></table></div><div class="item hidden" id="6080adaaec901916050494bc"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/membrane-protein-opm">Membrane Protein (OPM)</a></td></tr></table></div><div class="item hidden" id="602c57ae3fed9e549afd7920"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/molecular-function">Molecular Function</a></td></tr></table></div><div class="item hidden" id="602c5a1e3fed9e549afd7925"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/membrane-protein-mpstruc">Membrane Protein (mpstruc)</a></td></tr></table></div><div class="item hidden" id="602c57133fed9e549afd791d"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/protein-symmetry">Protein Symmetry</a></td></tr></table></div><div class="item hidden" id="602c57603fed9e549afd791e"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/scop-e">SCOP-e</a></td></tr></table></div><div class="item hidden" id="6141014def055f03d1f222d4"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/scop2">SCOP2</a></td></tr></table></div><div class="item hidden" id="602c56f13fed9e549afd791c"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/search-and-browse/browse-options/source-organism">Source Organism</a></td></tr></table></div><div class="item hidden" id="6000bab4d3c1ff0cf1f44f48"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/search-and-browse/mypdb">MyPDB</a></td></tr></table></div><div class="group show" id="618271c92a7d828464a7d146" onclick="toggle("618271c92a7d828464a7d146")"><table><tr><td style="padding-left: 4px">Exploring a 3D Structure</td><td><span class="glyphicon glyphicon-triangle-bottom" id="glyph618271c92a7d828464a7d146"></span></td></tr></table></div><div class="item hidden" id="618274c904fb9835c6ae189a"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/overview">Overview</a></td></tr></table></div><div class="item hidden" id="618271f904fb9835c6ae1892"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/structure-summary-page">Structure Summary Page</a></td></tr></table></div><div class="item hidden" id="6182729704fb9835c6ae1893"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/structure">Structure</a></td></tr></table></div><div class="item hidden" id="618272c004fb9835c6ae1894"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/annotations">Annotations</a></td></tr></table></div><div class="item hidden" id="618272e004fb9835c6ae1895"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/experiment">Experiment</a></td></tr></table></div><div class="item hidden" id="618272fb04fb9835c6ae1896"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/sequence">Sequence</a></td></tr></table></div><div class="item hidden" id="6182730904fb9835c6ae1897"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/genome">Genome</a></td></tr></table></div><div class="item hidden" id="6182731a04fb9835c6ae1898"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/ligands">Ligands</a></td></tr></table></div><div class="item hidden" id="6182732a04fb9835c6ae1899"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/exploring-a-3d-structure/versions">Versions</a></td></tr></table></div><div class="group show" id="5fd3e3a6eb210c2c5632d098" onclick="toggle("5fd3e3a6eb210c2c5632d098")"><table><tr><td style="padding-left: 4px">3D Viewers</td><td><span class="glyphicon glyphicon-triangle-bottom" id="glyph5fd3e3a6eb210c2c5632d098"></span></td></tr></table></div><div class="group hidden" id="5f98cc9614cc37a34de620ea" onclick="toggle("5f98cc9614cc37a34de620ea")"><table><tr><td style="padding-left: 24px">Mol*</td><td><span class="glyphicon glyphicon-triangle-bottom" id="glyph5f98cc9614cc37a34de620ea"></span></td></tr></table></div><div class="item hidden" id="5ee0fc4d25aa7b208a9fe39e"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/3d-viewers/mol*/getting-started">Getting Started</a></td></tr></table></div><div class="item hidden" id="5ee107b225aa7b208a9fe3a1"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/3d-viewers/mol*/maneuvering-in-mol*">Maneuvering in Mol*</a></td></tr></table></div><div class="item hidden" id="5ee10ad725aa7b208a9fe3a2"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/3d-viewers/mol*/making-selections">Making Selections</a></td></tr></table></div><div class="item hidden" id="5ee1046625aa7b208a9fe3a0"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/3d-viewers/mol*/navigating-by-sequence">Navigating by Sequence</a></td></tr></table></div><div class="item hidden" id="5ee1192f25aa7b208a9fe3a3"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/3d-viewers/mol*/managing-the-display">Managing the Display</a></td></tr></table></div><div class="item hidden" id="5ee13ac17f50f44e6aa4fb1f"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/3d-viewers/mol*/common-actions">Common Actions</a></td></tr></table></div><div class="item hidden" id="5ee231607f50f44e6aa4fb20"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/3d-viewers/mol*/faqs-scenarios">FAQs/Scenarios</a></td></tr></table></div><div class="item hidden" id="5ee253237f50f44e6aa4fb22"><table><tr><td class="title" style="padding-left: 44px"><a href="/docs/3d-viewers/mol*/mol*-cheat-sheet">Mol* Cheat Sheet</a></td></tr></table></div><div class="item hidden" id="60075352c5ab5836659ab2e3"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/3d-viewers/jmol">Jmol</a></td></tr></table></div><div class="item hidden" id="65a4b499c76ca3abcc925d0d"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/3d-viewers/ngl-to-mol*-ui-migration-guide">NGL to Mol* UI Migration Guide</a></td></tr></table></div><div class="group show" id="6256b2b3b4396e45e97bf3de" onclick="toggle("6256b2b3b4396e45e97bf3de")"><table><tr><td style="padding-left: 4px">Grouping Structures</td><td><span class="glyphicon glyphicon-triangle-top" id="glyph6256b2b3b4396e45e97bf3de"></span></td></tr></table></div><div class="item show" id="62fbafaf3b6e49562fa5c055"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/grouping-structures/overview-grouping-structures">Overview: Grouping Structures</a></td></tr></table></div><div class="item show" id="6081c10aec901916050494be"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/grouping-structures/sequence-based-clustering">Sequence-based Clustering</a></td></tr></table></div><div class="item show" id="6256b3269c3931864b07285b"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/grouping-structures/grouping-search-results">Grouping Search Results</a></td></tr></table></div><div class="item show" id="6256b35e9c3931864b07285c"><table><tr><td class="title" style="padding-left: 24px"><a class="docs-index-link" href="/docs/grouping-structures/group-summary-pages">Group Summary Pages</a></td><td><span class="glyphicon glyphicon-chevron-right"></span></td></tr></table></div><div class="item show" id="6364336066d6046810db7f11"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/grouping-structures/explore-sequence-alignments-in-3d">Explore Sequence Alignments in 3D</a></td></tr></table></div><div class="group show" id="5fd3e3f4eb210c2c56332c65" onclick="toggle("5fd3e3f4eb210c2c56332c65")"><table><tr><td style="padding-left: 4px">Sequence Viewers</td><td><span class="glyphicon glyphicon-triangle-bottom" id="glyph5fd3e3f4eb210c2c56332c65"></span></td></tr></table></div><div class="item hidden" id="60103d1ab1afe64903398251"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/sequence-viewers/sequence-annotations-viewer">Sequence Annotations Viewer</a></td></tr></table></div><div class="item hidden" id="60342ff52087e87def0d0b09"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/sequence-viewers/sequence-annotations-in-3d">Sequence Annotations in 3D</a></td></tr></table></div><div class="item hidden" id="5fc7f2843fb4b83beb6a7a3d"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/sequence-viewers/genome-view">Genome View</a></td></tr></table></div><div class="item hidden" id="60182dc1ecb9a74be53123aa"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/sequence-viewers/protein-sequence-alignment-view">Protein Sequence Alignment View</a></td></tr></table></div><div class="group show" id="60132e62aeeea33d3f095fa8" onclick="toggle("60132e62aeeea33d3f095fa8")"><table><tr><td style="padding-left: 4px">Tools</td><td><span class="glyphicon glyphicon-triangle-bottom" id="glyph60132e62aeeea33d3f095fa8"></span></td></tr></table></div><div class="item hidden" id="60132e6a610d04019e01d4c2"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/tools/pairwise-structure-alignment">Pairwise Structure Alignment</a></td></tr></table></div><div class="group show" id="600217ee5b6ad53203751b79" onclick="toggle("600217ee5b6ad53203751b79")"><table><tr><td style="padding-left: 4px">Programmatic Access</td><td><span class="glyphicon glyphicon-triangle-bottom" id="glyph600217ee5b6ad53203751b79"></span></td></tr></table></div><div class="item hidden" id="602d94713fed9e549afd7926"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/programmatic-access/file-download-services">File Download Services</a></td></tr></table></div><div class="item hidden" id="60398336fec59804432bfc37"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/programmatic-access/web-apis-overview">Web APIs Overview</a></td></tr></table></div><div class="item hidden" id="60183326ecb9a74be53123ab"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/programmatic-access/batch-downloads-with-shell-script">Batch Downloads with Shell Script</a></td></tr></table></div><div class="item hidden" id="610337d7ef055f03d1f222b9"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/programmatic-access/migrating-from-legacy-apis">Migrating from Legacy APIs</a></td></tr></table></div><div class="item hidden" id="60033e6ccff89d5fc8f8a3f2"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/programmatic-access/access-to-legacy-theoretical-models">Access to Legacy Theoretical Models</a></td></tr></table></div><div class="group show" id="601024f3244a4309df5d6630" onclick="toggle("601024f3244a4309df5d6630")"><table><tr><td style="padding-left: 4px">Additional Resources</td><td><span class="glyphicon glyphicon-triangle-bottom" id="glyph601024f3244a4309df5d6630"></span></td></tr></table></div><div class="item hidden" id="6010260ee244795fc6dcb836"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/additional-resources/3d-printing">3D Printing</a></td></tr></table></div><div class="item hidden" id="6010260ee244795fc6dcb839"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/additional-resources/databases-and-knowledgebases">Databases and Knowledgebases</a></td></tr></table></div><div class="item hidden" id="6010260ee244795fc6dcb838"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/additional-resources/crystallography-software">Crystallography Software</a></td></tr></table></div><div class="item hidden" id="63ee50cac031758bf1c30ff4"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/additional-resources/electron-microscopy-software">Electron Microscopy Software</a></td></tr></table></div><div class="item hidden" id="60135c8f236b8b22a9824a4a"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/additional-resources/modeling-and-simulation-software">Modeling and Simulation Software</a></td></tr></table></div><div class="item hidden" id="6010260ee244795fc6dcb83a"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/additional-resources/file-readers">File Readers</a></td></tr></table></div><div class="item hidden" id="6010260ee244795fc6dcb83d"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/additional-resources/nmr-software">NMR Software</a></td></tr></table></div><div class="item hidden" id="6010260ee244795fc6dcb83c"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/additional-resources/molecular-graphics-software">Molecular Graphics Software</a></td></tr></table></div><div class="item hidden" id="60102b1ab1afe6490339824f"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/additional-resources/sequence-analysis">Sequence Analysis</a></td></tr></table></div><div class="item hidden" id="6168521eef055f03d1f2231b"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/additional-resources/sars-cov-2-and-covid-19">SARS-CoV-2 and COVID-19</a></td></tr></table></div><div class="item hidden" id="6010260ee244795fc6dcb83e"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/additional-resources/structure-classification-and-analysis">Structure Classification and Analysis</a></td></tr></table></div><div class="item hidden" id="63dc03c2c031758bf1c30ff0"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/additional-resources/data-management-standards-and-best-practices">Data Management Standards and Best Practices</a></td></tr></table></div><div class="item hidden" id="6317770e831916e52206a1ea"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/additional-resources/structure-prediction">Structure Prediction</a></td></tr></table></div><div class="item hidden" id="6010260ee244795fc6dcb837"><table><tr><td class="title" style="padding-left: 24px"><a href="/docs/additional-resources/structure-validation-and-quality">Structure Validation and Quality</a></td></tr></table></div></div></div></div><div class="col-lg-9 col-md-8 col-sm-12 content-item"><div data-elastic-include><h5 class="menu-path">Grouping Structures</h5><h1>Group Summary Pages</h1><div><div style="padding-left:20px;">● <a href="#introduction">Introduction</a></div> <div style="padding-left:40px;">○ <a href="#what-is-a-group-summary-page">What is a Group Summary Page?</a></div> <div style="padding-left:40px;">○ <a href="#why-use-the-group-summary-page">Why use the Group Summary Page?</a></div> <div style="padding-left:20px;">● <a href="#documentation">Documentation</a></div> <div style="padding-left:40px;">○ <a href="#types-of-group-summary-pages">Types of Group Summary Pages</a></div> <div style="padding-left:40px;">○ <a href="#accessing-group-summary-pages">Accessing Group Summary Pages</a></div> <div style="padding-left:40px;">○ <a href="#exploring-group-summary-pages">Exploring Group Summary Pages</a></div> <div style="padding-left:60px;">■ <a href="#structure-groups">Structure Groups</a></div> <div style="padding-left:80px;">□ <a href="#summary-page-grouped-by-pdb-deposit-group-id-">Summary page grouped by PDB Deposit Group ID </a></div> <div style="padding-left:100px;">◆ <a href="#what-is-on-the-page">What is on the page?</a></div> <div style="padding-left:100px;">◆ <a href="#navigating-the-page">Navigating the page</a></div> <div style="padding-left:60px;">■ <a href="#polymer-entity-groups">Polymer Entity Groups</a></div> <div style="padding-left:80px;">□ <a href="#summary-page-grouped-by-uniprot-accession">Summary page grouped by UniProt Accession</a></div> <div style="padding-left:100px;">◆ <a href="#what-is-on-the-group-summary-tab">What is on the Group Summary Tab?</a></div> <div style="padding-left:100px;">◆ <a href="#navigating-the-page">Navigating the page</a></div> <div style="padding-left:100px;">◆ <a href="#what-is-on-the-group-sequence-tab">What is on the Group Sequence Tab?</a></div> <div style="padding-left:80px;">□ <a href="#summary-page-grouped-by-sequence-identity-clusters">Summary page grouped by Sequence Identity Clusters</a></div> <div style="padding-left:100px;">◆ <a href="#what-is-on-the-sequence-cluster-group-summary-page">What is on the Sequence Cluster Group Summary Page?</a></div> <div style="padding-left:100px;">◆ <a href="#navigating-the-page">Navigating the page</a></div> <div style="padding-left:100px;">◆ <a href="#what-is-on-the-group-sequence-tab">What is on the Group Sequence Tab?</a></div> <div style="padding-left:20px;">● <a href="#example-to-explore">Example to explore</a></div> <div style="padding-left:20px;">● <a href="#references">References</a></div> <a class="content-anchor" id="introduction"></a> <h2>Introduction</h2> <p>In the Protein Data Bank (PDB), a large number of proteins have many structural entries in the archive. This redundancy of biomolecular structures in the archive provides opportunities to explore the range of biological properties, interactions, and functions of these proteins. In most cases these structures provide snap-shots of the protein in a variety of contexts - e.g., in different pH, temperature, or other environments and in the presence of one or more ions, ligands, cofactors, substrates, and/or other biomolecules (proteins, peptides, nucleic acids, carbohydrates, lipids). Grouping structures in different ways can allow users to appreciate the range of interactions and functions of a specific biological macromolecule. Several approaches have been used to organize and group polymer sequences, structures, and assemblies in the PDB archive to simplify and/or expedite analysis, and examine ranges, patterns, and trends in structure-function relationships.</p> <a class="content-anchor" id="what-is-a-group-summary-page"></a> <h3>What is a Group Summary Page?</h3> <p>The Group Summary Pages (GSPs) provide overviews of key features, properties, sequence alignments, and annotations of any predetermined or custom group of structures. This is in contrast to the <a href="/docs/exploring-a-3d-structure/structure-summary-page" target="_blank">Structure Summary Pages</a> (SSPs) that provide a quick overview of key details of a single structure in the PDB. Each group summary page also provides access to amino acid sequence information of all members of the group, ranges of amino acid sequences that are included in each member of the group, as well as structural and functional annotations of the sequence drawn from a variety of experimental and bioinformatics data resources.</p> <a class="content-anchor" id="why-use-the-group-summary-page"></a> <h3>Why use the Group Summary Page?</h3> <p>The Group Summary Pages provides easy access to groups of structures in the archive (organized by specific attributes and features) to explore patterns, trends, and ranges of conformational flexibility of all or parts of the proteins and relationships that may not be obvious in structures coming from individual experiments. This page also provides the opportunity to further refine group membership based on a variety of criteria including experimental features, source organism, protein domain classification, and protein function.</p> <a class="content-anchor" id="documentation"></a> <h2>Documentation</h2> <a class="content-anchor" id="types-of-group-summary-pages"></a> <h3>Types of Group Summary Pages</h3> <p>Group summary pages are available for predetermined groups, and may be created for custom groups of structures and/or sequences in the PDB archive.</p> <ul style="list-style-type:disc;"> <li>Predetermined groups in the PDB archive include groups of structures that share a specific identifier or property. For example:</li> <ul style="list-style-type:disc;"> <li>PDB Deposit Group ID based groups of structure (e.g., G_1002057). Membership in these groups is determined by the authors submitting these structures and frequently represents a single protein target bound to a series of ligands, drugs, and/or drug candidates. Other criteria may also be used for deciding on group membership. </li> <li>UniProt based groups including all polymer sequences in the PDB archive with the same UniProt Accession (e.g., P07550)</li> <li>Sequence cluster based groups including all polymer sequences in the PDB archive that belong to a specific sequence cluster. These groups are computed following each weekly update of the archive and may change from week to week. Learn more about sequence clusters in the PDB. </li> </ul> <li>Custom groups can be formed by combining specific search/browse criteria with relevant predetermined groups. For example: </li> <ul style="list-style-type:disc;"> <li>Grouping search results of any simple or complex query or browse exploration of the archive may be grouped by structures (using PDB Deposit Group IDs) or sequences (using UniProt Accession or sequence clusters). </li> </ul> </ul> <div style="height: 20px;"></div><a class="content-anchor" id="accessing-group-summary-pages"></a> <h3>Accessing Group Summary Pages</h3> <p>The group summary pages can be accessed in a few different ways:</p> <ul style="list-style-type:disc;"> <li>By grouping Search/Browse Results </li> <ul style="list-style-type:disc;"> <li>The results returned from a simple or composite search or browse explorations may either be listed completely or grouped by specific criteria and either only representatives are shown or lists of groups are shown with links to Custom Group Summary pages. Learn <a href="/docs/grouping-structures/grouping-search-results" target="_blank">more about options for viewing and grouping search results</a>. </li> </ul> <li>From Structure Summary pages </li> <ul style="list-style-type:disc;"> <li>You can explore the group members of a whole group using links placed on the Structure Summary page. Links to predetermined groups that are displayed on the page and marked by a box including an icon with a stack of papers (indicating a group of structures). Clicking on these icons (see Figures 1 and 2) will open the corresponding Group Summary pages</li> </ul> </ul> <div style="height: 20px;"></div><div style="width:80%"><table><tr><td><a href="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig1-20231213.png" data-toggle="lightbox" data-title="Figure 1: Click to view group of structures with a specific PDB Deposit Group ID, as marked in the header section of the Structure Summary page."><img class="img-responsive content-img-border" src="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig1-20231213.png" alt="Figure 1: Click to view group of structures with a specific PDB Deposit Group ID, as marked in the header section of the Structure Summary page."> </a></td></tr><tr><td class="content-img-caption" style="width:1170px;">Figure 1: Click to view group of structures with a specific PDB Deposit Group ID, as marked in the header section of the Structure Summary page.</td></tr></table></div><div style="height: 20px;"></div><div style="width:80%"><table><tr><td><a href="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig2.png" data-toggle="lightbox" data-title="Figure 2: In the Macromolecules section of the Structure Summary page (e.g., PDB ID 5qif), click to view groups with a specific UniProt Accessions for protein macromolecule entities, and links to pre-computed sequence clusters (e.g., at 30%, 50%, 70%, 90%, 95%, and 100%) that include the specific PDB entry. "><img class="img-responsive content-img-border" src="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig2.png" alt="Figure 2: In the Macromolecules section of the Structure Summary page (e.g., PDB ID 5qif), click to view groups with a specific UniProt Accessions for protein macromolecule entities, and links to pre-computed sequence clusters (e.g., at 30%, 50%, 70%, 90%, 95%, and 100%) that include the specific PDB entry. "> </a></td></tr><tr><td class="content-img-caption" style="width:1170px;">Figure 2: In the Macromolecules section of the Structure Summary page (e.g., PDB ID 5qif), click to view groups with a specific UniProt Accessions for protein macromolecule entities, and links to pre-computed sequence clusters (e.g., at 30%, 50%, 70%, 90%, 95%, and 100%) that include the specific PDB entry. </td></tr></table></div><div style="height: 20px;"></div><ul style="list-style-type:disc;"> <li>From Non-redundant Protein Sequence Statistics tables </li> <ul style="list-style-type:disc;"> <li>Search capabilities are available from the tabular view for statistics that summarize <a href="/stats/nr/cluster-ids-30" target="_blank">unique protein clusters in the PDB archive</a> and <a href="/stats/growth/nr/cluster-ids-30" target="_blank">growth in these clusters</a>. </li> <ul style="list-style-type:disc;"> <li>Select the sequence identity cluster of interest and option to view annual or cumulative growth in the corresponding level of sequence identity. </li> <li>Click on the statistics table at the bottom of the page to view the corresponding grouped polymer entities.</li> </ul> <li>New statistics are added to summarize <a href="/stats/nr/matching-uniprot" target="_blank">unique UniProtKB entries with known 3D structure </a>from the PDB archive and <a href="/stats/growth/nr/matching-uniprot" target="_blank">growth in UniProtKB entries</a>. </li> <ul style="list-style-type:disc;"> <li>Select the year of interest to view annual or cumulative growth of structures of polymer entities that map to a known UniProt Accession. </li> <li>Click on the statistics table at the bottom of the page to view the corresponding grouped polymer entities.</li> </ul> </ul> </ul> <div style="height: 20px;"></div><a class="content-anchor" id="exploring-group-summary-pages"></a> <h3>Exploring Group Summary Pages</h3> <p>Currently available Group Summary Pages are of the following type:</p> <ul style="list-style-type:disc;"> <li><b>Structure Groups</b>, which presents summaries of the contents and properties of the structures along with a few functional annotations mapped to these structures. </li> <li><b>Polymer entity Groups</b>, which present summaries of the contents and properties of the structure, a few functional annotations mapped to these polymers, and a variety of views of multiple sequence alignments of polymer sequences in the groups.</li> </ul> <div style="height: 20px;"></div><a class="content-anchor" id="structure-groups"></a> <h4>Structure Groups</h4> <a class="content-anchor" id="summary-page-grouped-by-pdb-deposit-group-id-"></a> <h5>Summary page grouped by PDB Deposit Group ID</h5> <p>This type of Group Summary Page summarizes information about structures entering the PDB archive via the GroupDep system and are assigned PDB Deposit Group Dep IDs. Typically members of these groups are the same protein, with different bound ligands. <br /><br />The contents and navigation of the Structure Group Summary page is explained with an example - a large-scale fragment screening against the SARS-CoV-2 main protease, one of the proteases essential for viral replication - PDB Deposit Group ID <a href="/groups/summary/entry/G_1002151" target="_blank">G_1002151</a>.</p> <a class="content-anchor" id="what-is-on-the-page"></a> <h6>What is on the page?</h6> <ul style="list-style-type:disc;"> <li>The top of the page (Figure 3) displays information about the group, a description of what is included in the group (provided by the authors), a place to browse through the images of structures in the group (on the left), and links to explore members in the group.</li> </ul> <div style="height: 20px;"></div><div style="width:80%"><table><tr><td><a href="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig3-20231213.png" data-toggle="lightbox" data-title="Figure 3: Top portion of the Group Summary page based on a PDB Deposition Group ID showing grouping criteria, description of what is included in the group, and links to explore group members. "><img class="img-responsive content-img-border" src="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig3-20231213.png" alt="Figure 3: Top portion of the Group Summary page based on a PDB Deposition Group ID showing grouping criteria, description of what is included in the group, and links to explore group members. "> </a></td></tr><tr><td class="content-img-caption" style="width:1170px;">Figure 3: Top portion of the Group Summary page based on a PDB Deposition Group ID showing grouping criteria, description of what is included in the group, and links to explore group members. </td></tr></table></div><div style="height: 20px;"></div><ul style="list-style-type:disc;"> <li>Scroll down on the page to see a variety of other information, including:</li> <ul style="list-style-type:disc;"> <li>Experimental features of structures in this group are summarized by a histogram showing method of structure determination and where appropriate, resolution of structures in the group.</li> <li>Properties and annotations about the structures in this group are summarized in a series of histograms showing the distribution of source organism, key domains, and functional annotations for members of the group.</li> <li>Small molecules associated with members of the group are listed as two histograms (see Figure 4) - one showing all the small molecules in these structures (including solvent molecules, buffer components, crystallization agents etc.) and another showing only ligands of interest. Learn <a href="/docs/general-help/ligand-structure-quality-in-pdb-structures" target="_blank">more about Ligands of Interest </a>here.</li> </ul> </ul> <div style="height: 20px;"></div><div style="width:80%"><table><tr><td><a href="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig4.png" data-toggle="lightbox" data-title="Figure 4: Group Summary page bottom showing histograms of number of entries with various small molecules (including Ligands of Interest). "><img class="img-responsive content-img-border" src="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig4.png" alt="Figure 4: Group Summary page bottom showing histograms of number of entries with various small molecules (including Ligands of Interest). "> </a></td></tr><tr><td class="content-img-caption" style="width:1170px;">Figure 4: Group Summary page bottom showing histograms of number of entries with various small molecules (including Ligands of Interest). </td></tr></table></div><div style="height: 20px;"></div><a class="content-anchor" id="navigating-the-page"></a> <h6>Navigating the page</h6> <ul style="list-style-type:disc;"> <li>By default, upto 10 rows of functional annotations and 20 rows of ligands are shown on the Group summary page. Additional annotations/ligands are listed below the histogram. Clicking on the + sign can add rows to the histogram and the - sign can be used to show fewer rows till the default limits are reached (see Figure 4). </li> <li>The histograms displayed on the Group Summary page are interactive and can be used to refine membership of the group. </li> <ul style="list-style-type:disc;"> <li>Clicking on a single blue bar in the histogram will refine the Group Summary Page. Members that do not match the criteria specified by this bar will be filtered out from this and all other histograms on the page, and shown in gray. </li> <li>For example, clicking on the ligand of interest with chemical component ID 6SU in the above small molecule histogram limits the group to include only (Figure 5).</li> <li>Clicking on a blue bar while holding the “shift” key will invoke search, showing all group members in the PDB archive that match the current condition. So clicking on the 6SU blue bar will yield the search result shown in Figure 6.</li> </ul> </ul> <div style="height: 20px;"></div><div style="width:80%"><table><tr><td><a href="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig5.png" data-toggle="lightbox" data-title="Figure 5: Updated histograms on Group Summary Page. Click on a blue bar to launch a search."><img class="img-responsive content-img-border" src="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig5.png" alt="Figure 5: Updated histograms on Group Summary Page. Click on a blue bar to launch a search."> </a></td></tr><tr><td class="content-img-caption" style="width:1170px;">Figure 5: Updated histograms on Group Summary Page. Click on a blue bar to launch a search.</td></tr></table></div><div style="height: 20px;"></div><div style="width:80%"><table><tr><td><a href="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig6-20231213.png" data-toggle="lightbox" data-title="Figure 6: Results of Search launched by clicking on a blue bar shown in Figure 5."><img class="img-responsive content-img-border" src="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig6-20231213.png" alt="Figure 6: Results of Search launched by clicking on a blue bar shown in Figure 5."> </a></td></tr><tr><td class="content-img-caption" style="width:1170px;">Figure 6: Results of Search launched by clicking on a blue bar shown in Figure 5.</td></tr></table></div><div style="height: 20px;"></div><a class="content-anchor" id="polymer-entity-groups"></a> <h4>Polymer Entity Groups</h4> <p>This type of Group Summary Page summarizes information about polymer entities in the group and also presents a <i>Group Sequence</i> view for exploration of sequence alignments, positional features of the group members, and locations of ligand interactions, where appropriate.</p> <a class="content-anchor" id="summary-page-grouped-by-uniprot-accession"></a> <h5>Summary page grouped by UniProt Accession</h5> <p>A majority of PDB structures contain proteins whose sequences and annotations are archived in UniProtKB/SwissProt. Often, PDB structures include partial sequences, stably folded domains, and may include modifications such as engineered mutations or sequence artifacts to facilitate expression or crystallization. The UniProt Group Summary Page provides a comprehensive overview on the relationship between the parts of protein sequence included in the PDB and UniProt data. This can be useful in assessing the availability and extent of 3D structural coverage of the protein of interest and identifying modifications in the sequence.<br /><br />The contents and navigation of the UniProt Group Summary page is explained with an example - all <a href="/groups/summary/polymer_entity/P0DTD1" target="_blank">polymer entities that map to UniProtKB accession P0DTD1 </a>- the Replicase polyprotein 1ab.</p> <a class="content-anchor" id="what-is-on-the-group-summary-tab"></a> <h6>What is on the Group Summary Tab?</h6> <ul style="list-style-type:disc;"> <li>The top of the page (Figure 7) displays information about the Group - the UniProt Accession, protein name and description, options to browse through the images of structures in the group (on the left), and links to explore members in the group in one of the following ways:</li> <ul style="list-style-type:disc;"> <li>View the sequence and structure alignment of group members (Sequence Alignments in 3D). Learn more about this feature. </li> <li>View the structure summary page for a selected structure</li> <li>View the 3D structure of the selected structure in Mol*.</li> </ul> </ul> <div style="height: 20px;"></div><div style="width:90%"><table><tr><td><a href="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig7-20231213.png" data-toggle="lightbox" data-title="Figure 7: Top portion of the Group Summary page based on UniProt Accession showing grouping criteria, description of what is included in the group, and links to explore group members individually and also align and compare group members. "><img class="img-responsive content-img-border" src="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig7-20231213.png" alt="Figure 7: Top portion of the Group Summary page based on UniProt Accession showing grouping criteria, description of what is included in the group, and links to explore group members individually and also align and compare group members. "> </a></td></tr><tr><td class="content-img-caption" style="width:1170px;">Figure 7: Top portion of the Group Summary page based on UniProt Accession showing grouping criteria, description of what is included in the group, and links to explore group members individually and also align and compare group members. </td></tr></table></div><div style="height: 20px;"></div><ul style="list-style-type:disc;"> <li>Scroll down on the page to see a variety of other information, including:</li> <ul style="list-style-type:disc;"> <li>A histogram showing the release dates of structures with member polymer entities. </li> <li>Experimental features of structures in this group are summarized by a histogram showing method of structure determination and where appropriate, resolution of structures in the group.</li> <li>Properties and annotations about the structures in this group are summarized in a series of histograms showing the distribution of source organism, key domains, and functional annotations for members of the group.</li> </ul> </ul> <div style="height: 20px;"></div><a class="content-anchor" id="navigating-the-page"></a> <h6>Navigating the page</h6> <ul style="list-style-type:disc;"> <li>The histograms displayed on the Group Summary page are interactive and can be used to refine membership of the group</li> <li>Polymer entities with specific features can be selected by clicking on the corresponding histogram. All other members of the group are filtered out and shown in gray. </li> <li>The "Explore in 3D: Sequence Alignment" link (below the structure image panel on the page) shows sequence and structure alignment of members belonging to the UniProt group. Learn <a href="/docs/grouping-structures/explore-sequence-alignments-in-3d" target="_blank">more about the sequence alignment in 3D</a>.</li> </ul> <div style="height: 20px;"></div><a class="content-anchor" id="what-is-on-the-group-sequence-tab"></a> <h6>What is on the Group Sequence Tab?</h6> <p>The Group Sequence page shows a summary of the contents of the group and type of grouping. If the grouping was done by UniProt identifiers, an additional link to view the sequence alignment in 3D for the group members is listed here. Learn <a href="/docs/grouping-structures/explore-sequence-alignments-in-3d" target="_blank">more about the sequence alignment in 3D</a>.</p> <div style="width:40%"><table><tr><td><a href="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig8-jan24.png" data-toggle="lightbox" data-title="Figure 8: Summary of Grouping at the top of the Sequence Tab of the Group summary page for a case where the polymer entity grouping was done by A. sequence identity, and B. UniProt accession."><img class="img-responsive" src="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig8-jan24.png" alt="Figure 8: Summary of Grouping at the top of the Sequence Tab of the Group summary page for a case where the polymer entity grouping was done by A. sequence identity, and B. UniProt accession."> </a></td></tr><tr><td class="content-img-caption" style="width:1100px;">Figure 8: Summary of Grouping at the top of the Sequence Tab of the Group summary page for a case where the polymer entity grouping was done by A. sequence identity, and B. UniProt accession.</td></tr></table></div><div style="height: 20px;"></div><p>Following the summary, there are 3 tabs with multiple sequence alignment of all members of the group, mapping of structural features from various resources on the UniProt sequence, and a mapping of the binding sites on the UniProt sequence.</p> <table><tr><td><a href="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig9-jan24.png" data-toggle="lightbox" data-title="Figure 9: Tabs to explore the group members in the Sequence Tab of the Group Summary page."><img class="img-responsive content-img-border" src="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig9-jan24.png" alt="Figure 9: Tabs to explore the group members in the Sequence Tab of the Group Summary page."> </a></td></tr><tr><td class="content-img-caption" style="width:1170px;">Figure 9: Tabs to explore the group members in the Sequence Tab of the Group Summary page.</td></tr></table><div style="height: 20px;"></div><ul style="list-style-type:disc;"> <li>The <i>Sequence Alignments</i> tab</li> <ul style="list-style-type:disc;"> <li>This tab depicts the sequence information from the UniProtKB and 3D structures from the PDB (Figure 10).</li> <li>Tracks grouped by the orange vertical bar describe regions or sites of interest in the sequence annotated by UniProt.</li> <li>PDB entity tracks, color-coded by the blue vertical bar, show structurally determined regions of PDB sequences and how these regions map to the UniProt sequence. Note that polymer entities present in different PDB structures map to different regions of the UniProt polyprotein sequence. </li> </ul> </ul> <div style="height: 20px;"></div><div style="width:80%"><table><tr><td><a href="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig10-jan24.png" data-toggle="lightbox" data-title="Figure 10: Sequence Alignment of polymer entities in specific PDB entries, mapped to a specific UniProt sequence, and showing functional regions and annotations. "><img class="img-responsive content-img-border" src="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig10-jan24.png" alt="Figure 10: Sequence Alignment of polymer entities in specific PDB entries, mapped to a specific UniProt sequence, and showing functional regions and annotations. "> </a></td></tr><tr><td class="content-img-caption" style="width:1104px;">Figure 10: Sequence Alignment of polymer entities in specific PDB entries, mapped to a specific UniProt sequence, and showing functional regions and annotations. </td></tr></table></div><div style="height: 20px;"></div><ul style="list-style-type:disc;"> <li>The <i>Structural Features</i> Tab</li> <ul style="list-style-type:disc;"> <li>This tab summarizes positional annotations for structural features such as structural domains from CATH, SCOP and PFAM (Figure 11).</li> <li>Tracks grouped by the blue vertical bar present secondary structural features derived from the PDB entries, while those grouped by an orange vertical bar represent annotations from non-PDB data resources. </li> </ul> </ul> <div style="height: 20px;"></div><div style="width:80%"><table><tr><td><a href="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig11-jan24.png" data-toggle="lightbox" data-title="Figure 11: Annotations of the UniProt sequence based on PDB and other data resources. "><img class="img-responsive content-img-border" src="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig11-jan24.png" alt="Figure 11: Annotations of the UniProt sequence based on PDB and other data resources. "> </a></td></tr><tr><td class="content-img-caption" style="width:1170px;">Figure 11: Annotations of the UniProt sequence based on PDB and other data resources. </td></tr></table></div><div style="height: 20px;"></div><ul style="list-style-type:disc;"> <li>The <i>Binding Sites </i>tab</li> <ul style="list-style-type:disc;"> <li>This tab summarizes the location specific ligand binding to the protein sequence (Figure 12).</li> <li>The Global Bindings track displays the aggregation of all protein-ligand binding sites for all group members.</li> </ul> </ul> <div style="height: 20px;"></div><div style="width:80%"><table><tr><td><a href="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig12-jan24.png" data-toggle="lightbox" data-title="Figure 12: Individual and Global ligands binding sites mapped to the UniProt sequence. "><img class="img-responsive content-img-border" src="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig12-jan24.png" alt="Figure 12: Individual and Global ligands binding sites mapped to the UniProt sequence. "> </a></td></tr><tr><td class="content-img-caption" style="width:1170px;">Figure 12: Individual and Global ligands binding sites mapped to the UniProt sequence. </td></tr></table></div><div style="height: 20px;"></div><a class="content-anchor" id="summary-page-grouped-by-sequence-identity-clusters"></a> <h5>Summary page grouped by Sequence Identity Clusters</h5> <p>The redundancy in PDB can help with ex<a href="/docs/grouping-structures/sequence-based-clustering" target="_blank"></a>ploring the functions of a protein in different contexts. Each week all protein sequences in the PDB archive are grouped at different levels of sequence identity (e.g., 100%, 95%, 90%, 70%, 50% and 30%) to yield sequence clusters. Learn more about Sequence Clusters here. The <i>Sequence Cluster Group Summary Page</i> provides an overview of closely related sequences in the PDB. Exploring these groups of structures can inform users about the structure-functional range of proteins in these groups. <br /><br />The contents and navigation of the Sequence Cluster Group Summary page is explained with an example of Ephrin type-A receptor 2 (PDB ID <a href="/structure/1MQB" target="_blank">1mqb</a>) and selecting the 50% sequence cluster.</p> <a class="content-anchor" id="what-is-on-the-sequence-cluster-group-summary-page"></a> <h6>What is on the Sequence Cluster Group Summary Page?</h6> <ul style="list-style-type:disc;"> <li>The top of the page (Figure 13) displays information about the group criteria, list of group members, options to browse through the images of structures in the group (on the left), and links to explore members in the group.</li> </ul> <div style="height: 20px;"></div><div style="width:80%"><table><tr><td><a href="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig13-jan24.png" data-toggle="lightbox" data-title="Figure 13: Top portion of the Group Summary page based on sequence clusters showing grouping criteria, list of group members, and links to explore them."><img class="img-responsive content-img-border" src="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig13-jan24.png" alt="Figure 13: Top portion of the Group Summary page based on sequence clusters showing grouping criteria, list of group members, and links to explore them."> </a></td></tr><tr><td class="content-img-caption" style="width:1170px;">Figure 13: Top portion of the Group Summary page based on sequence clusters showing grouping criteria, list of group members, and links to explore them.</td></tr></table></div><div style="height: 20px;"></div><ul style="list-style-type:disc;"> <li>Scroll down on the page to see a variety of other information, including:</li> <ul style="list-style-type:disc;"> <li>A histogram showing the release dates of structures with member polymer entities. </li> <li>Experimental features of structures in this group are summarized by a histogram showing method of structure determination and where appropriate, resolution of structures in the group.</li> <li>Properties and annotations about the structures in this group are summarized in a series of histograms showing the distribution of source organism, key domains, and functional annotations for members of the group.</li> </ul> </ul> <div style="height: 20px;"></div><a class="content-anchor" id="navigating-the-page"></a> <h6>Navigating the page</h6> <ul style="list-style-type:disc;"> <li>The histograms displayed on the Group Summary page are interactive and can be used to refine membership of the group</li> <li>Polymer entities with specific features can be selected by clicking on the corresponding histogram. All other members of the group are filtered out and shown in gray. </li> </ul> <div style="height: 20px;"></div><a class="content-anchor" id="what-is-on-the-group-sequence-tab"></a> <h6>What is on the Group Sequence Tab?</h6> <p>The Group Sequence page shows 3 tabs with multiple sequence alignment of all members of the group, mapping of structural features from various resources on the UniProt sequence, and a mapping of the binding sites on the UniProt sequence.</p> <ul style="list-style-type:disc;"> <li>The <i>Alignments</i> tab</li> <ul style="list-style-type:disc;"> <li>This tab depicts sequence identity groups (Figure 14) and displays sequence alignment for group members using the interactive Protein Feature View tool.</li> </ul> </ul> <div style="height: 20px;"></div><div style="width:80%"><table><tr><td><a href="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig14-jan24.png" data-toggle="lightbox" data-title="Figure 14: Multiple Sequence Alignment of polymer entities mapped to the consensus sequence of the sequence cluster. The top red boxes denotes the consensus sequence; the 'Sequence Variation" row presents the conservation of amino acid sequence at any given position; and the rows of purple and gray text shows the amino acid sequences."><img class="img-responsive content-img-border" src="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig14-jan24.png" alt="Figure 14: Multiple Sequence Alignment of polymer entities mapped to the consensus sequence of the sequence cluster. The top red boxes denotes the consensus sequence; the 'Sequence Variation" row presents the conservation of amino acid sequence at any given position; and the rows of purple and gray text shows the amino acid sequences."> </a></td></tr><tr><td class="content-img-caption" style="width:1170px;">Figure 14: Multiple Sequence Alignment of polymer entities mapped to the consensus sequence of the sequence cluster. The top red boxes denotes the consensus sequence; the "Sequence Variation" row presents the conservation of amino acid sequence at any given position; and the rows of purple and gray text shows the amino acid sequences.</td></tr></table></div><div style="height: 20px;"></div><ul style="list-style-type:disc;"> <li>The multiple sequence alignment is generated using Clustal Omega, a general purpose multiple sequence alignment program (<a href="https://doi.org/10.1002/pro.3290" target="_blank">Seivers and Higgings 2017</a>). The alignment view initially captures the full length of the protein sequence. When you sufficiently zoom in, you see the polymer composition of aligned regions. A dash (-) symbol represents a gap in the alignment.</li> <li>The Consensus Sequence is shown in the first row of the alignment and shows the most frequent residues found at each position in the sequence alignment. It serves as a simplified representation for a set of sequences.</li> <li>The Conservation row highlights highly conserved and less conserved amino acid positions based on the relative frequency of occurring residues. In protein families highly conserved residues are more likely to have a functional role. This track has a frequency-based coloring scheme going from dark to light blue, with darker blue color representing higher conservation. </li> <li>Even in very close homologous, sequence substitutions can occur at any given alignment position. Point the mouse cursor to any position on the Consensus Sequence track. A tooltip will show the occurrences of all amino acids in the aligned position and their relative frequencies. </li> <li>Note: Multiple sequence alignments are precomputed for full groups. When a group subset is displayed, the original full group alignment is filtered and only the subset sequences are included. If a gap was present in the original alignment it will remain present in the subgroup.</li> </ul> <div style="height: 20px;"></div><ul style="list-style-type:disc;"> <li>The <i>Structural Features</i> tab </li> <ul style="list-style-type:disc;"> <li>This tab summarizes positional annotations for structural features on the consensus sequence (Figure 15), such as structural domains or secondary structure assignments. </li> <li>Color gradient indicates the frequency with which a given feature occurs at a given position. More intense colors indicate a higher frequency. Hover over any track at any position to see how often this feature occurs.</li> </ul> </ul> <div style="height: 20px;"></div><div style="width:80%"><table><tr><td><a href="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig15-jan24.png" data-toggle="lightbox" data-title="Figure 15: Annotations derived from various sources on the consensus sequence of the cluster."><img class="img-responsive content-img-border" src="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig15-jan24.png" alt="Figure 15: Annotations derived from various sources on the consensus sequence of the cluster."> </a></td></tr><tr><td class="content-img-caption" style="width:1170px;">Figure 15: Annotations derived from various sources on the consensus sequence of the cluster.</td></tr></table></div><div style="height: 20px;"></div><ul style="list-style-type:disc;"> <li>The <i>Binding Sites</i> tab </li> <ul style="list-style-type:disc;"> <li>This tab collects positional features for residues that interact with ligands.</li> <li>The <b>Global Bindings track </b>displays the aggregation of all protein-ligand binding sites for all group members. Each position in the alignment displays the number of times an aligned residue has been observed to interact with a ligand (Figure 16). The remaining tracks show the protein-ligand binding site frequencies for specific compounds. Thus, each position displays the fraction between the observed residue-ligand interactions and the total number of interactions between the ligand and group members. </li> </ul> </ul> <div style="height: 20px;"></div><div style="width:80%"><table><tr><td><a href="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig16-jan24.png" data-toggle="lightbox" data-title="Figure 16: Individual and Global ligands binding sites mapped to the cluster consensus sequence. "><img class="img-responsive content-img-border" src="https://cdn.rcsb.org/rcsb-pdb/content/6256b35e9c3931864b07285c/gs-fig16-jan24.png" alt="Figure 16: Individual and Global ligands binding sites mapped to the cluster consensus sequence. "> </a></td></tr><tr><td class="content-img-caption" style="width:1170px;">Figure 16: Individual and Global ligands binding sites mapped to the cluster consensus sequence. </td></tr></table></div><div style="height: 20px;"></div><a class="content-anchor" id="example-to-explore"></a> <h2>Example to explore</h2> <p>Query the PDB archive for all <a href="/search?request=%7B%22query%22%3A%7B%22type%22%3A%22group%22%2C%22nodes%22%3A%5B%7B%22type%22%3A%22group%22%2C%22nodes%22%3A%5B%7B%22type%22%3A%22group%22%2C%22nodes%22%3A%5B%7B%22type%22%3A%22group%22%2C%22nodes%22%3A%5B%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22text%22%2C%22parameters%22%3A%7B%22attribute%22%3A%22rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession%22%2C%22operator%22%3A%22in%22%2C%22value%22%3A%5B%22P0DTD1%22%5D%7D%7D%2C%7B%22type%22%3A%22terminal%22%2C%22service%22%3A%22text%22%2C%22parameters%22%3A%7B%22attribute%22%3A%22rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name%22%2C%22operator%22%3A%22exact_match%22%2C%22value%22%3A%22UniProt%22%7D%7D%5D%2C%22logical_operator%22%3A%22and%22%2C%22label%22%3A%22nested-attribute%22%7D%5D%2C%22logical_operator%22%3A%22and%22%7D%5D%2C%22logical_operator%22%3A%22and%22%2C%22label%22%3A%22text%22%7D%5D%2C%22logical_operator%22%3A%22and%22%7D%2C%22return_type%22%3A%22entry%22%2C%22request_options%22%3A%7B%22paginate%22%3A%7B%22start%22%3A0%2C%22rows%22%3A25%7D%2C%22scoring_strategy%22%3A%22combined%22%2C%22sort%22%3A%5B%7B%22sort_by%22%3A%22score%22%2C%22direction%22%3A%22desc%22%7D%5D%7D%2C%22request_info%22%3A%7B%22query_id%22%3A%2287c745a7f5150f31adce73c4ae62545d%22%7D%7D" target="_blank">polymer entities that map to UniProtKB Accession P0DTD1</a> (Replicase polyprotein 1ab polyprotein in SARS-CoV-2). Change the Return type to Polymer Entities, group the results at 30% sequence identity cluster and examine the resulting groups.</p> <ul style="list-style-type:disc;"> <li>What do these groups represent? </li> <li>What can you learn about these groups of polymer entities?</li> </ul> <div style="height: 20px;"></div><a class="content-anchor" id="references"></a> <h2>References</h2> <ul style="list-style-type:disc;"> <li>Sievers F, Higgins DG. Clustal Omega for making accurate alignments of many protein sequences. Protein Sci. 2018;27(1):135-145. doi:<a href="https://doi.org/10.1002/pro.3290" target="_blank">10.1002/pro.3290</a></li> </ul> <div style="height: 20px;"></div></div></div><br><hr><div class="item-info"><div>Please report any encountered broken links to <a href='mailto:info@rcsb.org'>info@rcsb.org</a></div><div>Last updated: 1/4/2024</div></div></div></div></div></div><div data-elastic-exclude><div class="hidden-print" id="footer_main"><div class="container" style="padding:0"><div class="row"><div class="col-md-6 col-sm-12" style="padding-left:0"> <div class="row"><div class="col-sm-4"><ul><li><span class="row_header">About</span></li><li><a href="/pages/about-us/index">About Us</a></li><li><a href="/pages/policies#References">Citing Us</a></li><li><a href="/pages/publications">Publications</a></li><li><a href="/pages/team">Team</a></li><li><a href="/pages/jobs">Careers</a></li><li><a href="/pages/policies">Usage & Privacy</a></li></ul></div><div class="col-sm-4" style="padding-left:0"><ul><li><span class="row_header">Support</span></li><li><a href="/pages/contactus">Contact Us</a></li><li><a href="/help">Help</a></li><li><a href="/docs/general-help/website-faq">Website FAQ</a></li><li><a href="/docs/general-help/glossary">Glossary</a></li><li><a href="https://status.rcsb.org/" target="_blank">Service Status</a></li></ul></div><div class="col-md-4 hidden-sm"></div></div></div><div class="col-md-6 col-sm-12" style="padding-left:5px"> <div class="row"><div class="col-sm-4"><p class="row_header">RCSB PDB is hosted by</p><div class="footerLogos"><hr><a href="https://radcollaboratory.rutgers.edu/"><img class="Rutgerslogo" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/rad-sm.png" alt="The Rutgers Artificial Intelligence and Data Science Collaboratory logo"></a><hr><a href="https://ucsd.edu/"><img class="UCSDlogo" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/Logo_UCSD-navy.png" alt="Uiversity of California San Diego logo"></a><a href="https://www.sdsc.edu/"><img class="SDSClogo" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/Logo_SDSC-black.png" alt="San Diego Supercomputer Center logo"></a><hr><a href="https://www.ucsf.edu/"><img class="UCSFlogo" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/Logo_UCSF.png" alt="University of California San Francisco Logo"></a></div></div><div class="col-sm-4"><p class="row_header">RCSB PDB is a member of the</p><div class="footerLogos"><span id="pdbmembers_footer"><hr><a href="https://www.wwpdb.org" target="_blank" rel="noopener"><img class="wwpdblogo" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/Logo_wwpdb.png" alt="wwPDB"></a><hr><a href="https://www.emdataresource.org" target="_blank" rel="noopener"><img id="emdatabanklogo_footer" src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/EMDataResourcelogo.png" alt="EMDataResource"></a></span></div></div><div class="col-sm-4"><ul><li><span class="row_header">RCSB Partners</span></li><li><a href="https://nakb.org/" target="_blank" rel="noopener">Nucleic Acid Knowledgebase</a></li></ul><ul><li><span class="row_header"><a href="https://www.wwpdb.org/" target="_blank" rel="noopener" style="text-decoration: none; color: black">wwPDB Partners</a></span></li><li><a href="/">RCSB PDB</a></li><li><a href="https://www.ebi.ac.uk/pdbe/" target="_blank" rel="noopener">PDBe</a></li><li><a href="https://www.pdbj.org/" target="_blank" rel="noopener">PDBj</a></li><li><a href="https://bmrb.io/" target="_blank" rel="noopener">BMRB</a></li><li><a href="https://emdb-empiar.org/" target="_blank" rel="noopener">EMDB</a></li></ul></div></div></div></div></div></div><div id="footer_grant"><div class="container"><div class="row"><p>RCSB PDB Core Operations are funded by the <a href="http://www.nsf.gov/" target="_blank" rel="noopener">U.S. National Science Foundation</a> (DBI-2321666), the <a href="http://science.energy.gov/" target="_blank" rel="noopener">US Department of Energy</a> (DE-SC0019749), and the <a href="http://www.cancer.gov/" target="_blank" rel="noopener">National Cancer Institute</a>, <a href="http://www.niaid.nih.gov/" target="_blank" rel="noopener">National Institute of Allergy and Infectious Diseases</a>, and <a href="http://www.nigms.nih.gov/" target="_blank" rel="noopener">National Institute of General Medical Sciences</a> of the <a href="http://www.nih.gov/" target="_blank" rel="noopener">National Institutes of Health</a> under grant R01GM157729.</p></div></div></div><div id="jira-fdbck"></div></div></div></body></html>