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class="Container_root__5fKNx"><header class="SectionTitleContainer_root__XGH__ text-dark-grey" data-testid="sectionTitleContainer"><div class="Markdown_root__pKQ5I" data-testid="root"><h2 style="text-align:center" class="SectionWrapperWithTitle_title__pmQu0 text-center" data-sb-field-path=".title">Recent News</h2></div></header><div class="" data-testid="root"><div class="Grid_grid__UAr5E" style="grid-template-columns:repeat(auto-fill, minmax(max(250px, 22%), 1fr))" data-testid="grid"><div class="Grid_gridItemWrapper__3STn4" data-testid="gridItemWrapper"><a class="group flex min-h-[250px] lg:min-h-[300px] p-[30px] hover:bg-primary bg-light-grey transition-colors duration-200 ease-linear" data-sb-link-ignore="false" href="/newsroom/newsreleases/2024/takeda-announces-strong-first-half-fy2024-results-and-raises-full-year-outlook/"><article class="flex flex-col justify-between w-full"><div class="MarkdownRedesign_root__YCuOn" data-testid="root"><h3 class="!my-6 !text-[16px] !font-semibold 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24.5H25.8047ZM18.6797 31.625C18.9023 31.625 19.125 31.5508 19.2734 31.4023C19.4219 31.2539 19.5703 31.0312 19.5703 30.7344V27.7656C19.5703 27.543 19.4219 27.3203 19.2734 27.1719C19.125 27.0234 18.9023 26.875 18.6797 26.875H15.7109C15.4141 26.875 15.1914 27.0234 15.043 27.1719C14.8945 27.3203 14.8203 27.543 14.8203 27.7656V30.7344C14.8203 31.0312 14.8945 31.2539 15.043 31.4023C15.1914 31.5508 15.4141 31.625 15.7109 31.625H18.6797ZM11.5547 31.625C11.7773 31.625 12 31.5508 12.1484 31.4023C12.2969 31.2539 12.4453 31.0312 12.4453 30.7344V27.7656C12.4453 27.543 12.2969 27.3203 12.1484 27.1719C12 27.0234 11.7773 26.875 11.5547 26.875H8.58594C8.28906 26.875 8.06641 27.0234 7.91797 27.1719C7.76953 27.3203 7.69531 27.543 7.69531 27.7656V30.7344C7.69531 31.0312 7.76953 31.2539 7.91797 31.4023C8.06641 31.5508 8.28906 31.625 8.58594 31.625H11.5547ZM25.8047 31.625C26.0273 31.625 26.25 31.5508 26.3984 31.4023C26.5469 31.2539 26.6953 31.0312 26.6953 30.7344V27.7656C26.6953 27.543 26.5469 27.3203 26.3984 27.1719C26.25 27.0234 26.0273 26.875 25.8047 26.875H22.8359C22.5391 26.875 22.3164 27.0234 22.168 27.1719C22.0195 27.3203 21.9453 27.543 21.9453 27.7656V30.7344C21.9453 31.0312 22.0195 31.2539 22.168 31.4023C22.3164 31.5508 22.5391 31.625 22.8359 31.625H25.8047Z" fill="currentColor"></path></svg><span class="text-[14px] ">October 31, 2024</span></div></article></a></div><div class="Grid_gridItemWrapper__3STn4" data-testid="gridItemWrapper"><a class="group flex min-h-[250px] lg:min-h-[300px] p-[30px] hover:bg-primary bg-light-grey transition-colors duration-200 ease-linear" data-sb-link-ignore="false" href="/newsroom/newsreleases/2024/notice-of-the-revised-forecast-of-consolidated-financials-for-fy2024-ifrs/"><article class="flex flex-col justify-between w-full"><div class="MarkdownRedesign_root__YCuOn" data-testid="root"><h3 class="!my-6 !text-[16px] !font-semibold group-hover:text-white text-primary !leading-tight line-clamp-4 hover:text-primary cursor-pointer">Notice of the Revised Forecast of Consolidated Financials for FY2024 (IFRS)</h3></div><div class="flex items-center mt-[8px] shrink-0 group-hover:text-white"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" fill="currentColor" viewBox="0 0 34 39" class="mr-[16px] w-[16px] h-[16px]" role="img" aria-hidden="false" data-testid="icon-dotcom/Calendar"><title>Calendar</title><path d="M30.2578 5.5C31.2227 5.5 32.0391 5.87109 32.7812 6.53906C33.4492 7.28125 33.8203 8.09766 33.8203 9.0625V35.1875C33.8203 36.2266 33.4492 37.043 32.7812 37.7109C32.0391 38.4531 31.2227 38.75 30.2578 38.75H4.13281C3.09375 38.75 2.27734 38.4531 1.60938 37.7109C0.867188 37.043 0.570312 36.2266 0.570312 35.1875V9.0625C0.570312 8.09766 0.867188 7.28125 1.60938 6.53906C2.27734 5.87109 3.09375 5.5 4.13281 5.5H7.69531V1.64062C7.69531 1.41797 7.76953 1.19531 7.91797 1.04688C8.06641 0.898438 8.28906 0.75 8.58594 0.75H9.17969C9.40234 0.75 9.625 0.898438 9.77344 1.04688C9.92188 1.19531 10.0703 1.41797 10.0703 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20.6406V23.6094C7.69531 23.9062 7.76953 24.1289 7.91797 24.2773C8.06641 24.4258 8.28906 24.5 8.58594 24.5H11.5547ZM18.6797 24.5C18.9023 24.5 19.125 24.4258 19.2734 24.2773C19.4219 24.1289 19.5703 23.9062 19.5703 23.6094V20.6406C19.5703 20.418 19.4219 20.1953 19.2734 20.0469C19.125 19.8984 18.9023 19.75 18.6797 19.75H15.7109C15.4141 19.75 15.1914 19.8984 15.043 20.0469C14.8945 20.1953 14.8203 20.418 14.8203 20.6406V23.6094C14.8203 23.9062 14.8945 24.1289 15.043 24.2773C15.1914 24.4258 15.4141 24.5 15.7109 24.5H18.6797ZM25.8047 24.5C26.0273 24.5 26.25 24.4258 26.3984 24.2773C26.5469 24.1289 26.6953 23.9062 26.6953 23.6094V20.6406C26.6953 20.418 26.5469 20.1953 26.3984 20.0469C26.25 19.8984 26.0273 19.75 25.8047 19.75H22.8359C22.5391 19.75 22.3164 19.8984 22.168 20.0469C22.0195 20.1953 21.9453 20.418 21.9453 20.6406V23.6094C21.9453 23.9062 22.0195 24.1289 22.168 24.2773C22.3164 24.4258 22.5391 24.5 22.8359 24.5H25.8047ZM18.6797 31.625C18.9023 31.625 19.125 31.5508 19.2734 31.4023C19.4219 31.2539 19.5703 31.0312 19.5703 30.7344V27.7656C19.5703 27.543 19.4219 27.3203 19.2734 27.1719C19.125 27.0234 18.9023 26.875 18.6797 26.875H15.7109C15.4141 26.875 15.1914 27.0234 15.043 27.1719C14.8945 27.3203 14.8203 27.543 14.8203 27.7656V30.7344C14.8203 31.0312 14.8945 31.2539 15.043 31.4023C15.1914 31.5508 15.4141 31.625 15.7109 31.625H18.6797ZM11.5547 31.625C11.7773 31.625 12 31.5508 12.1484 31.4023C12.2969 31.2539 12.4453 31.0312 12.4453 30.7344V27.7656C12.4453 27.543 12.2969 27.3203 12.1484 27.1719C12 27.0234 11.7773 26.875 11.5547 26.875H8.58594C8.28906 26.875 8.06641 27.0234 7.91797 27.1719C7.76953 27.3203 7.69531 27.543 7.69531 27.7656V30.7344C7.69531 31.0312 7.76953 31.2539 7.91797 31.4023C8.06641 31.5508 8.28906 31.625 8.58594 31.625H11.5547ZM25.8047 31.625C26.0273 31.625 26.25 31.5508 26.3984 31.4023C26.5469 31.2539 26.6953 31.0312 26.6953 30.7344V27.7656C26.6953 27.543 26.5469 27.3203 26.3984 27.1719C26.25 27.0234 26.0273 26.875 25.8047 26.875H22.8359C22.5391 26.875 22.3164 27.0234 22.168 27.1719C22.0195 27.3203 21.9453 27.543 21.9453 27.7656V30.7344C21.9453 31.0312 22.0195 31.2539 22.168 31.4023C22.3164 31.5508 22.5391 31.625 22.8359 31.625H25.8047Z" fill="currentColor"></path></svg><span class="text-[14px] ">October 31, 2024</span></div></article></a></div><div class="Grid_gridItemWrapper__3STn4" data-testid="gridItemWrapper"><a class="group flex min-h-[250px] lg:min-h-[300px] p-[30px] hover:bg-primary bg-light-grey transition-colors duration-200 ease-linear" data-sb-link-ignore="false" href="/newsroom/newsreleases/2024/first-half-fiscal-year-2024/"><article class="flex flex-col justify-between w-full"><div class="MarkdownRedesign_root__YCuOn" data-testid="root"><h3 class="!my-6 !text-[16px] !font-semibold group-hover:text-white text-primary !leading-tight line-clamp-4 hover:text-primary cursor-pointer">Takeda to Hold Earnings Call for Fiscal Year 2024 1st Half on October 31</h3></div><div class="flex items-center mt-[8px] shrink-0 group-hover:text-white"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" fill="currentColor" viewBox="0 0 34 39" class="mr-[16px] w-[16px] h-[16px]" role="img" aria-hidden="false" data-testid="icon-dotcom/Calendar"><title>Calendar</title><path d="M30.2578 5.5C31.2227 5.5 32.0391 5.87109 32.7812 6.53906C33.4492 7.28125 33.8203 8.09766 33.8203 9.0625V35.1875C33.8203 36.2266 33.4492 37.043 32.7812 37.7109C32.0391 38.4531 31.2227 38.75 30.2578 38.75H4.13281C3.09375 38.75 2.27734 38.4531 1.60938 37.7109C0.867188 37.043 0.570312 36.2266 0.570312 35.1875V9.0625C0.570312 8.09766 0.867188 7.28125 1.60938 6.53906C2.27734 5.87109 3.09375 5.5 4.13281 5.5H7.69531V1.64062C7.69531 1.41797 7.76953 1.19531 7.91797 1.04688C8.06641 0.898438 8.28906 0.75 8.58594 0.75H9.17969C9.40234 0.75 9.625 0.898438 9.77344 1.04688C9.92188 1.19531 10.0703 1.41797 10.0703 1.64062V5.5H24.3203V1.64062C24.3203 1.41797 24.3945 1.19531 24.543 1.04688C24.6914 0.898438 24.9141 0.75 25.2109 0.75H25.8047C26.0273 0.75 26.25 0.898438 26.3984 1.04688C26.5469 1.19531 26.6953 1.41797 26.6953 1.64062V5.5H30.2578ZM4.13281 7.875C3.76172 7.875 3.46484 8.02344 3.24219 8.24609C3.01953 8.46875 2.94531 8.76562 2.94531 9.0625V12.625H31.4453V9.0625C31.4453 8.76562 31.2969 8.46875 31.0742 8.24609C30.8516 8.02344 30.5547 7.875 30.2578 7.875H4.13281ZM30.2578 36.375C30.5547 36.375 30.8516 36.3008 31.0742 36.0781C31.2969 35.8555 31.4453 35.5586 31.4453 35.1875V15H2.94531V35.1875C2.94531 35.5586 3.01953 35.8555 3.24219 36.0781C3.46484 36.3008 3.76172 36.375 4.13281 36.375H30.2578ZM11.5547 24.5C11.7773 24.5 12 24.4258 12.1484 24.2773C12.2969 24.1289 12.4453 23.9062 12.4453 23.6094V20.6406C12.4453 20.418 12.2969 20.1953 12.1484 20.0469C12 19.8984 11.7773 19.75 11.5547 19.75H8.58594C8.28906 19.75 8.06641 19.8984 7.91797 20.0469C7.76953 20.1953 7.69531 20.418 7.69531 20.6406V23.6094C7.69531 23.9062 7.76953 24.1289 7.91797 24.2773C8.06641 24.4258 8.28906 24.5 8.58594 24.5H11.5547ZM18.6797 24.5C18.9023 24.5 19.125 24.4258 19.2734 24.2773C19.4219 24.1289 19.5703 23.9062 19.5703 23.6094V20.6406C19.5703 20.418 19.4219 20.1953 19.2734 20.0469C19.125 19.8984 18.9023 19.75 18.6797 19.75H15.7109C15.4141 19.75 15.1914 19.8984 15.043 20.0469C14.8945 20.1953 14.8203 20.418 14.8203 20.6406V23.6094C14.8203 23.9062 14.8945 24.1289 15.043 24.2773C15.1914 24.4258 15.4141 24.5 15.7109 24.5H18.6797ZM25.8047 24.5C26.0273 24.5 26.25 24.4258 26.3984 24.2773C26.5469 24.1289 26.6953 23.9062 26.6953 23.6094V20.6406C26.6953 20.418 26.5469 20.1953 26.3984 20.0469C26.25 19.8984 26.0273 19.75 25.8047 19.75H22.8359C22.5391 19.75 22.3164 19.8984 22.168 20.0469C22.0195 20.1953 21.9453 20.418 21.9453 20.6406V23.6094C21.9453 23.9062 22.0195 24.1289 22.168 24.2773C22.3164 24.4258 22.5391 24.5 22.8359 24.5H25.8047ZM18.6797 31.625C18.9023 31.625 19.125 31.5508 19.2734 31.4023C19.4219 31.2539 19.5703 31.0312 19.5703 30.7344V27.7656C19.5703 27.543 19.4219 27.3203 19.2734 27.1719C19.125 27.0234 18.9023 26.875 18.6797 26.875H15.7109C15.4141 26.875 15.1914 27.0234 15.043 27.1719C14.8945 27.3203 14.8203 27.543 14.8203 27.7656V30.7344C14.8203 31.0312 14.8945 31.2539 15.043 31.4023C15.1914 31.5508 15.4141 31.625 15.7109 31.625H18.6797ZM11.5547 31.625C11.7773 31.625 12 31.5508 12.1484 31.4023C12.2969 31.2539 12.4453 31.0312 12.4453 30.7344V27.7656C12.4453 27.543 12.2969 27.3203 12.1484 27.1719C12 27.0234 11.7773 26.875 11.5547 26.875H8.58594C8.28906 26.875 8.06641 27.0234 7.91797 27.1719C7.76953 27.3203 7.69531 27.543 7.69531 27.7656V30.7344C7.69531 31.0312 7.76953 31.2539 7.91797 31.4023C8.06641 31.5508 8.28906 31.625 8.58594 31.625H11.5547ZM25.8047 31.625C26.0273 31.625 26.25 31.5508 26.3984 31.4023C26.5469 31.2539 26.6953 31.0312 26.6953 30.7344V27.7656C26.6953 27.543 26.5469 27.3203 26.3984 27.1719C26.25 27.0234 26.0273 26.875 25.8047 26.875H22.8359C22.5391 26.875 22.3164 27.0234 22.168 27.1719C22.0195 27.3203 21.9453 27.543 21.9453 27.7656V30.7344C21.9453 31.0312 22.0195 31.2539 22.168 31.4023C22.3164 31.5508 22.5391 31.625 22.8359 31.625H25.8047Z" fill="currentColor"></path></svg><span class="text-[14px] ">October 17, 2024</span></div></article></a></div><div class="Grid_gridItemWrapper__3STn4" data-testid="gridItemWrapper"><a class="group flex min-h-[250px] lg:min-h-[300px] p-[30px] hover:bg-primary bg-light-grey transition-colors duration-200 ease-linear" data-sb-link-ignore="false" href="/newsroom/newsreleases/2024/takeda-receives-approval-for-fruzaqla-in-japan-for-the-treatment-of-unresectable-advanced-or-recurrent-colorectal-cancer/"><article class="flex flex-col justify-between w-full"><div class="MarkdownRedesign_root__YCuOn" data-testid="root"><h3 class="!my-6 !text-[16px] !font-semibold group-hover:text-white text-primary !leading-tight line-clamp-4 hover:text-primary cursor-pointer">Takeda Receives Approval for FRUZAQLA (fruquintinib) in Japan for the Treatment of Unresectable Advanced or Recurrent Colorectal Cancer</h3></div><div class="flex items-center mt-[8px] shrink-0 group-hover:text-white"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" fill="currentColor" viewBox="0 0 34 39" class="mr-[16px] w-[16px] h-[16px]" role="img" aria-hidden="false" data-testid="icon-dotcom/Calendar"><title>Calendar</title><path d="M30.2578 5.5C31.2227 5.5 32.0391 5.87109 32.7812 6.53906C33.4492 7.28125 33.8203 8.09766 33.8203 9.0625V35.1875C33.8203 36.2266 33.4492 37.043 32.7812 37.7109C32.0391 38.4531 31.2227 38.75 30.2578 38.75H4.13281C3.09375 38.75 2.27734 38.4531 1.60938 37.7109C0.867188 37.043 0.570312 36.2266 0.570312 35.1875V9.0625C0.570312 8.09766 0.867188 7.28125 1.60938 6.53906C2.27734 5.87109 3.09375 5.5 4.13281 5.5H7.69531V1.64062C7.69531 1.41797 7.76953 1.19531 7.91797 1.04688C8.06641 0.898438 8.28906 0.75 8.58594 0.75H9.17969C9.40234 0.75 9.625 0.898438 9.77344 1.04688C9.92188 1.19531 10.0703 1.41797 10.0703 1.64062V5.5H24.3203V1.64062C24.3203 1.41797 24.3945 1.19531 24.543 1.04688C24.6914 0.898438 24.9141 0.75 25.2109 0.75H25.8047C26.0273 0.75 26.25 0.898438 26.3984 1.04688C26.5469 1.19531 26.6953 1.41797 26.6953 1.64062V5.5H30.2578ZM4.13281 7.875C3.76172 7.875 3.46484 8.02344 3.24219 8.24609C3.01953 8.46875 2.94531 8.76562 2.94531 9.0625V12.625H31.4453V9.0625C31.4453 8.76562 31.2969 8.46875 31.0742 8.24609C30.8516 8.02344 30.5547 7.875 30.2578 7.875H4.13281ZM30.2578 36.375C30.5547 36.375 30.8516 36.3008 31.0742 36.0781C31.2969 35.8555 31.4453 35.5586 31.4453 35.1875V15H2.94531V35.1875C2.94531 35.5586 3.01953 35.8555 3.24219 36.0781C3.46484 36.3008 3.76172 36.375 4.13281 36.375H30.2578ZM11.5547 24.5C11.7773 24.5 12 24.4258 12.1484 24.2773C12.2969 24.1289 12.4453 23.9062 12.4453 23.6094V20.6406C12.4453 20.418 12.2969 20.1953 12.1484 20.0469C12 19.8984 11.7773 19.75 11.5547 19.75H8.58594C8.28906 19.75 8.06641 19.8984 7.91797 20.0469C7.76953 20.1953 7.69531 20.418 7.69531 20.6406V23.6094C7.69531 23.9062 7.76953 24.1289 7.91797 24.2773C8.06641 24.4258 8.28906 24.5 8.58594 24.5H11.5547ZM18.6797 24.5C18.9023 24.5 19.125 24.4258 19.2734 24.2773C19.4219 24.1289 19.5703 23.9062 19.5703 23.6094V20.6406C19.5703 20.418 19.4219 20.1953 19.2734 20.0469C19.125 19.8984 18.9023 19.75 18.6797 19.75H15.7109C15.4141 19.75 15.1914 19.8984 15.043 20.0469C14.8945 20.1953 14.8203 20.418 14.8203 20.6406V23.6094C14.8203 23.9062 14.8945 24.1289 15.043 24.2773C15.1914 24.4258 15.4141 24.5 15.7109 24.5H18.6797ZM25.8047 24.5C26.0273 24.5 26.25 24.4258 26.3984 24.2773C26.5469 24.1289 26.6953 23.9062 26.6953 23.6094V20.6406C26.6953 20.418 26.5469 20.1953 26.3984 20.0469C26.25 19.8984 26.0273 19.75 25.8047 19.75H22.8359C22.5391 19.75 22.3164 19.8984 22.168 20.0469C22.0195 20.1953 21.9453 20.418 21.9453 20.6406V23.6094C21.9453 23.9062 22.0195 24.1289 22.168 24.2773C22.3164 24.4258 22.5391 24.5 22.8359 24.5H25.8047ZM18.6797 31.625C18.9023 31.625 19.125 31.5508 19.2734 31.4023C19.4219 31.2539 19.5703 31.0312 19.5703 30.7344V27.7656C19.5703 27.543 19.4219 27.3203 19.2734 27.1719C19.125 27.0234 18.9023 26.875 18.6797 26.875H15.7109C15.4141 26.875 15.1914 27.0234 15.043 27.1719C14.8945 27.3203 14.8203 27.543 14.8203 27.7656V30.7344C14.8203 31.0312 14.8945 31.2539 15.043 31.4023C15.1914 31.5508 15.4141 31.625 15.7109 31.625H18.6797ZM11.5547 31.625C11.7773 31.625 12 31.5508 12.1484 31.4023C12.2969 31.2539 12.4453 31.0312 12.4453 30.7344V27.7656C12.4453 27.543 12.2969 27.3203 12.1484 27.1719C12 27.0234 11.7773 26.875 11.5547 26.875H8.58594C8.28906 26.875 8.06641 27.0234 7.91797 27.1719C7.76953 27.3203 7.69531 27.543 7.69531 27.7656V30.7344C7.69531 31.0312 7.76953 31.2539 7.91797 31.4023C8.06641 31.5508 8.28906 31.625 8.58594 31.625H11.5547ZM25.8047 31.625C26.0273 31.625 26.25 31.5508 26.3984 31.4023C26.5469 31.2539 26.6953 31.0312 26.6953 30.7344V27.7656C26.6953 27.543 26.5469 27.3203 26.3984 27.1719C26.25 27.0234 26.0273 26.875 25.8047 26.875H22.8359C22.5391 26.875 22.3164 27.0234 22.168 27.1719C22.0195 27.3203 21.9453 27.543 21.9453 27.7656V30.7344C21.9453 31.0312 22.0195 31.2539 22.168 31.4023C22.3164 31.5508 22.5391 31.625 22.8359 31.625H25.8047Z" fill="currentColor"></path></svg><span class="text-[14px] ">September 24, 2024</span></div></article></a></div></div></div><div class="flex justify-center align-middle mt-[40px]"><a href="/newsroom/press-releases" class="Link_link___T3Ow">View All</a></div></div></section><section data-section-position="2" data-sb-field-path="sections.2" data-section-name="" data-exclude-from-nav="false" class="global-pt global-pb global-mt global-mb bg-white flex flex-col justify-center border-none"><div class="Container_root__5fKNx"><div class="flex w-full max-w-screen-xl"><div class="w-1/1"><p class="TextBody_subtitle__oHV1Y text-dark-grey" data-sb-field-path=".subtitle">We exist to create better health for people and a brighter future for the world. While the science and technology we advance are constantly evolving, our ambition remains. We move science forward, so we can transform more lives.</p><div class="MarkdownRedesign_root__YCuOn" data-testid="root"><div class="TextBody_markdownText__NAlzY text-dark-grey" data-sb-field-path=".text"></div></div></div></div></div></section><section data-section-position="3" data-sb-field-path="sections.3" data-section-name="## Better Health, Brighter Future " data-exclude-from-nav="false" class="global-pt global-pb global-mt global-mb bg-white"><div class="Container_root__5fKNx"><header class="SectionTitleContainer_root__XGH__ text-dark-grey" data-testid="sectionTitleContainer"><div class="Markdown_root__pKQ5I" data-testid="root"><h2 id="Better_Health_Brighter_Future" class="SectionWrapperWithTitle_title__pmQu0 text-center" data-sb-field-path=".title">Better Health, Brighter Future</h2></div></header><div data-sb-field-path=".cards" class="" data-testid="root"><div class="Grid_grid__UAr5E" style="grid-template-columns:repeat(auto-fill, minmax(max(250px, 30%), 1fr))" data-testid="grid"><div class="Grid_gridItemWrapper__3STn4 last:!border-b-0" data-testid="gridItemWrapper"><div data-sb-field-path=".0" class="group h-full flex flex-col bg-light-grey"><a class="block" data-sb-link-ignore="false" href="/careers/"><div data-sb-field-path=".image"><span class="ImageBlock_root__p_rMO ImageBlock_rootFill__ts5qS ImageBlock_rootLimitWidth__EMprg ImageBlock_rootGlobalBorderRadius__HvsBo !h-[230px]" data-testid="root" style="aspect-ratio:885 / 395"><img alt="two women in a laboratory" __metadata="[object Object]" loading="lazy" decoding="async" data-nimg="fill" class="ImageBlock_image__sHiB_ w-full" style="position:absolute;height:100%;width:100%;left:0;top:0;right:0;bottom:0;object-fit:cover;color:transparent;aspect-ratio:885 / 395;background-size:cover;background-position:50% 50%;background-repeat:no-repeat;background-image:url("data:image/svg+xml;charset=utf-8,%3Csvg xmlns='http://www.w3.org/2000/svg' %3E%3Cfilter id='b' color-interpolation-filters='sRGB'%3E%3CfeGaussianBlur stdDeviation='20'/%3E%3CfeColorMatrix values='1 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 100 -1' result='s'/%3E%3CfeFlood x='0' y='0' width='100%25' height='100%25'/%3E%3CfeComposite operator='out' in='s'/%3E%3CfeComposite in2='SourceGraphic'/%3E%3CfeGaussianBlur stdDeviation='20'/%3E%3C/filter%3E%3Cimage width='100%25' height='100%25' x='0' y='0' preserveAspectRatio='xMidYMid slice' style='filter: url(%23b);' href='data:image/webp;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAECAMAAACA5l7/AAAARVBMVEXY2NnV1NShp6RsZWKxqqTKxsq0srHFwsHi4eLNzM3t7e2omI+Sm5zg2NiValbOyMJdTUZ8QyLItqyufWi9rqVCnZm4moP9O2iWAAAAL0lEQVQI1wXBhwEAIAgDsCoo4N7/n2oClnHg3swFRJtNVuMI0X49klaPoMEEDhY/IJkBTu1/RuYAAAAASUVORK5CYII='/%3E%3C/svg%3E")" sizes="(max-width: 572px) 100vw, (max-width: 885px) 50vw, (max-width: 2000px) 33vw, 25vw" srcSet="https://assets-dam.takeda.com/image/upload/c_lfill,w_128/q_auto:eco/f_auto/v1/legacy-dotcom/siteassets/system/careers/careers-banner 128w, https://assets-dam.takeda.com/image/upload/c_lfill,w_256/q_auto:eco/f_auto/v1/legacy-dotcom/siteassets/system/careers/careers-banner 256w, https://assets-dam.takeda.com/image/upload/c_lfill,w_384/q_auto:eco/f_auto/v1/legacy-dotcom/siteassets/system/careers/careers-banner 384w, https://assets-dam.takeda.com/image/upload/c_lfill,w_480/q_auto:eco/f_auto/v1/legacy-dotcom/siteassets/system/careers/careers-banner 480w, https://assets-dam.takeda.com/image/upload/c_lfill,w_640/q_auto:eco/f_auto/v1/legacy-dotcom/siteassets/system/careers/careers-banner 640w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1080/q_auto:eco/f_auto/v1/legacy-dotcom/siteassets/system/careers/careers-banner 1080w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1200/q_auto:eco/f_auto/v1/legacy-dotcom/siteassets/system/careers/careers-banner 1200w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/q_auto:eco/f_auto/v1/legacy-dotcom/siteassets/system/careers/careers-banner 1920w" 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data-sb-link-ignore="false" data-sb-field-path=".callToAction" href="/careers/"><div class="MarkdownRedesign_root__YCuOn" data-testid="root"><strong class="text-cta">FIND OUT MORE</strong></div></a></div></div></div><div class="Grid_gridItemWrapper__3STn4 last:!border-b-0" data-testid="gridItemWrapper"><div data-sb-field-path=".1" class="group h-full flex flex-col bg-light-grey"><a class="block" data-sb-link-ignore="false" href="/investors/overview/"><div data-sb-field-path=".image"><span class="ImageBlock_root__p_rMO ImageBlock_rootFill__ts5qS ImageBlock_rootLimitWidth__EMprg ImageBlock_rootGlobalBorderRadius__HvsBo !h-[230px]" data-testid="root" style="aspect-ratio:6000 / 4000"><img alt="People shaking hands in office" __metadata="[object Object]" loading="lazy" decoding="async" data-nimg="fill" class="ImageBlock_image__sHiB_ w-full" style="position:absolute;height:100%;width:100%;left:0;top:0;right:0;bottom:0;object-fit:cover;color:transparent;aspect-ratio:6000 / 4000;background-size:cover;background-position:50% 50%;background-repeat:no-repeat;background-image:url("data:image/svg+xml;charset=utf-8,%3Csvg xmlns='http://www.w3.org/2000/svg' %3E%3Cfilter id='b' color-interpolation-filters='sRGB'%3E%3CfeGaussianBlur stdDeviation='20'/%3E%3CfeColorMatrix values='1 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 100 -1' result='s'/%3E%3CfeFlood x='0' y='0' width='100%25' height='100%25'/%3E%3CfeComposite operator='out' in='s'/%3E%3CfeComposite in2='SourceGraphic'/%3E%3CfeGaussianBlur stdDeviation='20'/%3E%3C/filter%3E%3Cimage width='100%25' height='100%25' x='0' y='0' preserveAspectRatio='xMidYMid slice' style='filter: url(%23b);' href='data:image/webp;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAHCAMAAAAGcixRAAAAdVBMVEW9wsCyopYkQFmNnp+kqK3AyMJiaXDS1tO5t7CKgX/FysWlrq+AjpBRY3FFWGSVnqCKkpVqb3SWh4R+c3KFhomOlpZ1amquuLMXMEfOqpp1jZ03Vm6ZnaGZnZx0eHvQzslBSlaKiounnJTMz9B/YVq5qaS4uLnN2xGSAAAASUlEQVQI1wXBBQKAIAAEsJNGUsDu/P8T3dD2nANSlg+dqurUyPcpGFUFfcqUgcnSuGUtBMfsm2vV4rAAIU7dex2DweACY8wsnv6XMwPm7/VdSgAAAABJRU5ErkJggg=='/%3E%3C/svg%3E")" sizes="(max-width: 572px) 100vw, (max-width: 885px) 50vw, (max-width: 2000px) 33vw, 25vw" srcSet="https://assets-dam.takeda.com/image/upload/c_lfill,w_128/q_auto:eco/f_auto/v1/Global/Investor/Investors 128w, https://assets-dam.takeda.com/image/upload/c_lfill,w_256/q_auto:eco/f_auto/v1/Global/Investor/Investors 256w, https://assets-dam.takeda.com/image/upload/c_lfill,w_384/q_auto:eco/f_auto/v1/Global/Investor/Investors 384w, https://assets-dam.takeda.com/image/upload/c_lfill,w_480/q_auto:eco/f_auto/v1/Global/Investor/Investors 480w, 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class="MarkdownRedesign_root__YCuOn" data-testid="root"><span class="line-clamp-3 text-text-color" data-sb-field-path=".description">Discover our balanced, diverse portfolio and strategy for sustainable, patient-centered and resilient growth.</span></div></div><a class="block mt-[1.25rem] w-fit after:mt-0.5 after:content-[''] after:block after:w-full after:h-[3px] after:bg-primary after:group-hover:bg-primary-active" data-sb-link-ignore="false" data-sb-field-path=".callToAction" href="/investors/overview/"><div class="MarkdownRedesign_root__YCuOn" data-testid="root"><strong class="text-cta">FIND OUT MORE</strong></div></a></div></div></div><div class="Grid_gridItemWrapper__3STn4 last:!border-b-0" data-testid="gridItemWrapper"><div data-sb-field-path=".2" class="group h-full flex flex-col bg-light-grey"><a class="block" data-sb-link-ignore="false" href="/science/research-and-development/"><div data-sb-field-path=".image"><span class="ImageBlock_root__p_rMO ImageBlock_rootFill__ts5qS ImageBlock_rootLimitWidth__EMprg ImageBlock_rootGlobalBorderRadius__HvsBo !h-[230px]" data-testid="root" style="aspect-ratio:2000 / 862"><img alt="man in labcoat" __metadata="[object Object]" loading="lazy" decoding="async" data-nimg="fill" class="ImageBlock_image__sHiB_ w-full" style="position:absolute;height:100%;width:100%;left:0;top:0;right:0;bottom:0;object-fit:cover;color:transparent;aspect-ratio:2000 / 862;background-size:cover;background-position:50% 50%;background-repeat:no-repeat;background-image:url("data:image/svg+xml;charset=utf-8,%3Csvg xmlns='http://www.w3.org/2000/svg' %3E%3Cfilter id='b' color-interpolation-filters='sRGB'%3E%3CfeGaussianBlur stdDeviation='20'/%3E%3CfeColorMatrix values='1 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 100 -1' result='s'/%3E%3CfeFlood x='0' y='0' width='100%25' height='100%25'/%3E%3CfeComposite operator='out' in='s'/%3E%3CfeComposite in2='SourceGraphic'/%3E%3CfeGaussianBlur stdDeviation='20'/%3E%3C/filter%3E%3Cimage width='100%25' height='100%25' x='0' y='0' preserveAspectRatio='xMidYMid slice' style='filter: url(%23b);' href='data:image/webp;base64,iVBORw0KGgoAAAANSUhEUgAAAAoAAAAEBAMAAABFFrP+AAAAJ1BMVEXS2uDY3uPP1925v8PAx9Gwra7JycjBwsW6mou/q6SnhHSjgXOvp6A/xFyBAAAAIElEQVQI12NQYBCyCWZgEhTMbmdgEhDIXM6gxCDgagIAKOgDtd/2M8kAAAAASUVORK5CYII='/%3E%3C/svg%3E")" sizes="(max-width: 572px) 100vw, (max-width: 885px) 50vw, (max-width: 2000px) 33vw, 25vw" srcSet="https://assets-dam.takeda.com/image/upload/c_lfill,w_128/q_auto:eco/f_auto/v1/Global/Research%20and%20Development/R_D_home_cf7hxl 128w, https://assets-dam.takeda.com/image/upload/c_lfill,w_256/q_auto:eco/f_auto/v1/Global/Research%20and%20Development/R_D_home_cf7hxl 256w, https://assets-dam.takeda.com/image/upload/c_lfill,w_384/q_auto:eco/f_auto/v1/Global/Research%20and%20Development/R_D_home_cf7hxl 384w, https://assets-dam.takeda.com/image/upload/c_lfill,w_480/q_auto:eco/f_auto/v1/Global/Research%20and%20Development/R_D_home_cf7hxl 480w, https://assets-dam.takeda.com/image/upload/c_lfill,w_640/q_auto:eco/f_auto/v1/Global/Research%20and%20Development/R_D_home_cf7hxl 640w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1080/q_auto:eco/f_auto/v1/Global/Research%20and%20Development/R_D_home_cf7hxl 1080w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1200/q_auto:eco/f_auto/v1/Global/Research%20and%20Development/R_D_home_cf7hxl 1200w, https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/q_auto:eco/f_auto/v1/Global/Research%20and%20Development/R_D_home_cf7hxl 1920w" src="https://assets-dam.takeda.com/image/upload/c_lfill,w_1920/q_auto:eco/f_auto/v1/Global/Research%20and%20Development/R_D_home_cf7hxl"/></span></div></a><div class="flex justify-between flex-col h-full px-6 pt-[2.125rem] pb-[2.935rem]"><div><a class="block" data-sb-link-ignore="false" href="/science/research-and-development/"><div class="MarkdownRedesign_root__YCuOn" data-testid="root"><h3 id="R_D-.2-2" class="line-clamp-3 !mb-[1.25rem] font-medium text-text-color group-hover:text-primary-active" data-sb-field-path=".title">R&D</h3></div></a><div class="MarkdownRedesign_root__YCuOn" data-testid="root"><span class="line-clamp-3 text-text-color" data-sb-field-path=".description">Fueled by our inherent curiosity, we translate science into highly innovative, life-transforming medicines.</span></div></div><a class="block mt-[1.25rem] w-fit after:mt-0.5 after:content-[''] after:block after:w-full after:h-[3px] after:bg-primary after:group-hover:bg-primary-active" data-sb-link-ignore="false" data-sb-field-path=".callToAction" href="/science/research-and-development/"><div class="MarkdownRedesign_root__YCuOn" data-testid="root"><strong class="text-cta">FIND OUT MORE</strong></div></a></div></div></div></div></div></div></section><section data-section-position="4" data-sb-field-path="sections.4" data-section-name="## Our Areas of Focus " data-exclude-from-nav="false" class="global-pt global-pb global-mt global-mb bg-white"><div class="Container_root__5fKNx"><header class="SectionTitleContainer_root__XGH__ text-dark-grey" data-testid="sectionTitleContainer"><div class="Markdown_root__pKQ5I" data-testid="root"><h2 id="Our_Areas_of_Focus" class="SectionWrapperWithTitle_title__pmQu0 text-center !mb-16" data-sb-field-path=".title">Our Areas of Focus</h2></div></header><div data-sb-field-path=".items" class="" data-testid="root"><div class="Grid_grid__UAr5E !gap-x-0 !gap-y-0 max-sm:!gap-y-0 !grid-cols-1 sm:!grid-cols-2 lg:!grid-cols-3 QuickLinksSectionRedesign_adaptiveBorders__mVr2N" style="grid-template-columns:repeat(auto-fill, minmax(max(250px, 30%), 1fr))" data-testid="grid"><div class="Grid_gridItemWrapper__3STn4" data-testid="gridItemWrapper"><a class="group flex flex-col items-center h-full px-6 cursor-pointer py-7" data-sb-link-ignore="false" data-sb-field-path=".0" href="/science/areas-of-focus/gastroenterology/"><div class="box-content flex-shrink-0 w-[62px] h-[62px] mb-[35px]"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" fill="currentColor" width="62" height="62" viewBox="0 0 62 62" class="w-full h-full object-cover text-primary" role="img" aria-hidden="true" __metadata="[object Object]" type="Icon" data-sb-field-path=".media.0" data-testid="icon-dotcom/DigestiveTractCircle"><path d="M61.0078 31.3242C61.0078 20.0614 54.8334 9.7479 44.892 4.42407C44.8692 4.40888 44.8465 4.41647 44.8237 4.40129C44.7401 4.36331 44.6566 4.34812 44.5731 4.32534C44.4743 4.29496 44.3756 4.26458 44.2693 4.26458C44.2465 4.26458 44.2313 4.24939 44.2085 4.24939C44.1478 4.24939 44.0946 4.27977 44.0338 4.28737C43.9275 4.30256 43.8212 4.31015 43.7225 4.34812C43.6389 4.3785 43.5706 4.42407 43.4946 4.46964C43.4111 4.51521 43.3275 4.56077 43.2592 4.62912C43.1832 4.69748 43.1301 4.77342 43.0693 4.85696C43.0313 4.91013 42.9782 4.9481 42.9402 5.00886C42.9326 5.03164 42.9326 5.05442 42.925 5.06961C42.887 5.15315 42.8643 5.25188 42.8415 5.34302C42.8187 5.43415 42.7883 5.52529 42.7883 5.61643C42.7883 5.63921 42.7731 5.66199 42.7731 5.68478V14.7907C42.7731 15.9755 41.8086 16.94 40.6238 16.94H20.574C17.802 16.94 15.5464 19.1956 15.5464 21.9676C15.5464 24.7397 17.802 26.9953 20.574 26.9953H40.6314C41.8162 26.9953 42.7807 27.9598 42.7807 29.1446C42.7807 30.3293 41.8162 31.2938 40.6314 31.2938H20.574C17.802 31.2938 15.5464 33.5494 15.5464 36.3215C15.5464 39.0935 17.802 41.3491 20.574 41.3491H40.6314C41.8162 41.3491 42.7807 42.3136 42.7807 43.4984C42.7807 44.6832 41.8162 45.6477 40.6314 45.6477H34.1001C31.328 45.6477 29.0724 47.9033 29.0724 50.6753V56.0751C29.0724 56.8725 29.718 57.5181 30.5154 57.5181C31.3128 57.5181 31.9584 56.8725 31.9584 56.0751V50.6753C31.9584 49.4906 32.9229 48.526 34.1077 48.526H40.639C43.4111 48.526 45.6667 46.2704 45.6667 43.4984C45.6667 40.7264 43.4111 38.4708 40.639 38.4708H20.574C19.3893 38.4708 18.4248 37.5062 18.4248 36.3215C18.4248 35.1367 19.3893 34.1722 20.574 34.1722H40.6314C43.4035 34.1722 45.6591 31.9166 45.6591 29.1446C45.6591 26.3725 43.4035 24.1169 40.6314 24.1169H20.574C19.3893 24.1169 18.4248 23.1524 18.4248 21.9676C18.4248 20.7829 19.3893 19.8184 20.574 19.8184H40.6314C43.4035 19.8184 45.6591 17.5628 45.6591 14.7907V8.23657C53.4056 13.3174 58.1295 21.9525 58.1295 31.3242C58.1295 46.5514 45.735 58.9459 30.5078 58.9459C15.2806 58.9459 2.88617 46.559 2.88617 31.3242C2.88617 16.0894 15.2806 3.70258 30.5078 3.70258C33.5684 3.70258 36.5759 4.19623 39.4467 5.18353C40.1986 5.44175 41.0188 5.03923 41.277 4.28737C41.5352 3.5355 41.1327 2.71528 40.3808 2.45706C37.2139 1.37103 33.8874 0.824219 30.5078 0.824219C13.6933 0.824219 0.0078125 14.5097 0.0078125 31.3242C0.0078125 48.1387 13.6933 61.8242 30.5078 61.8242C47.3223 61.8242 61.0078 48.1387 61.0078 31.3242Z"></path></svg></div><div class="mb-3"><div class="MarkdownRedesign_root__YCuOn" data-testid="root"><h3 id="Gastrointestinal_and_Inflammation-sections.4-1d896b09-b0fd-4773-b127-c63c24fa9d1a" class="text-center text-xl font-medium text-dark-grey group-hover:text-primary-active transition-colors !mb-0" data-sb-field-path=".linkLabel">Gastrointestinal and Inflammation</h3></div></div><p class="mb-16 text-body-block text-center text-dark-grey" data-sb-field-path=".description">Understanding and addressing life-limiting gastrointestinal and inflammatory diseases</p><div class="flex items-center justify-end w-full mt-auto"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" fill="currentColor" width="24" height="24" viewBox="0 0 24 24" class="w-[32px] h-[32px] text-primary group-hover:text-primary-active" role="img" aria-hidden="false" data-testid="icon-ChevronDefaultRight"><title>Go to Gastrointestinal and Inflammation page</title><path d="M9.707 18.707l6-6c0.391-0.391 0.391-1.024 0-1.414l-6-6c-0.391-0.391-1.024-0.391-1.414 0s-0.391 1.024 0 1.414l5.293 5.293-5.293 5.293c-0.391 0.391-0.391 1.024 0 1.414s1.024 0.391 1.414 0z"></path></svg></div></a></div><div class="Grid_gridItemWrapper__3STn4" data-testid="gridItemWrapper"><a 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45.8497 34.3055 44.9951C34.38 44.9724 34.4544 44.9649 34.5214 44.9346C36.6572 44.3221 38.8229 43.1424 40.8843 41.0477L40.8992 41.0326C42.9458 38.9454 44.1365 36.7751 44.7468 34.567C44.7617 34.5367 44.7617 34.4989 44.7691 34.4687C46.0492 29.7348 44.6947 24.8421 43.4444 20.3578L43.4295 20.3199C42.5067 17.0002 41.6286 13.8619 41.6732 10.8295C41.6807 10.217 41.7402 9.64224 41.8221 9.06752L53.5805 21.0157C51.4075 21.356 49.2269 21.061 47.1134 20.5922C46.3543 20.4258 45.6026 20.9174 45.4389 21.6887C45.3347 22.1802 45.491 22.6718 45.8185 23.0045C46.0045 23.1936 46.2427 23.3297 46.518 23.3902C49.6362 24.0708 53.0894 24.4564 56.5499 23.2011C56.7434 23.1784 56.9146 23.1104 57.0858 23.0045C58.7677 22.3088 60.4421 21.2123 62.0794 19.5486C62.6301 18.989 62.6301 18.0816 62.0794 17.522" fill="currentColor"></path></svg></div><div class="mb-3"><div class="MarkdownRedesign_root__YCuOn" data-testid="root"><h3 id="Rare_Diseases-sections.4-61d60e37-c92b-4b7e-bd44-beac7ec66a54" class="text-center text-xl font-medium text-dark-grey group-hover:text-primary-active transition-colors !mb-0" data-sb-field-path=".linkLabel">Rare Diseases</h3></div></div><p class="mb-16 text-body-block text-center text-dark-grey" data-sb-field-path=".description">Working to transform treatments in immunology, hematology, metabolic and lysosomal storage disorders</p><div class="flex items-center justify-end w-full mt-auto"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" fill="currentColor" width="24" height="24" viewBox="0 0 24 24" class="w-[32px] h-[32px] text-primary group-hover:text-primary-active" role="img" aria-hidden="false" data-testid="icon-ChevronDefaultRight"><title>Go to Rare Diseases page</title><path d="M9.707 18.707l6-6c0.391-0.391 0.391-1.024 0-1.414l-6-6c-0.391-0.391-1.024-0.391-1.414 0s-0.391 1.024 0 1.414l5.293 5.293-5.293 5.293c-0.391 0.391-0.391 1.024 0 1.414s1.024 0.391 1.414 0z"></path></svg></div></a></div><div class="Grid_gridItemWrapper__3STn4" data-testid="gridItemWrapper"><a 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data-sb-field-path=".linkLabel">Plasma-Derived Therapies</h3></div></div><p class="mb-16 text-body-block text-center text-dark-grey" data-sb-field-path=".description">Improving the lives of patients with rare and complex chronic diseases through innovation in plasma</p><div class="flex items-center justify-end w-full mt-auto"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" fill="currentColor" width="24" height="24" viewBox="0 0 24 24" class="w-[32px] h-[32px] text-primary group-hover:text-primary-active" role="img" aria-hidden="false" data-testid="icon-ChevronDefaultRight"><title>Go to Plasma-Derived Therapies page</title><path d="M9.707 18.707l6-6c0.391-0.391 0.391-1.024 0-1.414l-6-6c-0.391-0.391-1.024-0.391-1.414 0s-0.391 1.024 0 1.414l5.293 5.293-5.293 5.293c-0.391 0.391-0.391 1.024 0 1.414s1.024 0.391 1.414 0z"></path></svg></div></a></div><div class="Grid_gridItemWrapper__3STn4" data-testid="gridItemWrapper"><a class="group flex flex-col items-center h-full px-6 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class="mb-3"><div class="MarkdownRedesign_root__YCuOn" data-testid="root"><h3 id="Oncology-sections.4-6af17d41-70ef-45d3-a41c-57ef7450ad37" class="text-center text-xl font-medium text-dark-grey group-hover:text-primary-active transition-colors !mb-0" data-sb-field-path=".linkLabel">Oncology</h3></div></div><p class="mb-16 text-body-block text-center text-dark-grey" data-sb-field-path=".description">Aspiring to cure cancer, with inspiration from patients and innovation from everywhere</p><div class="flex items-center justify-end w-full mt-auto"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" fill="currentColor" width="24" height="24" viewBox="0 0 24 24" class="w-[32px] h-[32px] text-primary group-hover:text-primary-active" role="img" aria-hidden="false" data-testid="icon-ChevronDefaultRight"><title>Go to Oncology page</title><path d="M9.707 18.707l6-6c0.391-0.391 0.391-1.024 0-1.414l-6-6c-0.391-0.391-1.024-0.391-1.414 0s-0.391 1.024 0 1.414l5.293 5.293-5.293 5.293c-0.391 0.391-0.391 1.024 0 1.414s1.024 0.391 1.414 0z"></path></svg></div></a></div><div class="Grid_gridItemWrapper__3STn4" data-testid="gridItemWrapper"><a class="group flex flex-col items-center h-full px-6 cursor-pointer py-7" data-sb-link-ignore="false" data-sb-field-path=".4" href="/science/areas-of-focus/neuroscience/"><div class="box-content flex-shrink-0 w-[62px] h-[62px] mb-[35px]"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" fill="currentColor" width="63" height="57" viewBox="0 0 63 57" class="w-full h-full object-cover text-primary" role="img" aria-hidden="true" __metadata="[object Object]" type="Icon" data-sb-field-path=".media.0" data-testid="icon-dotcom/Brain"><path d="M48.0868 22.0508C49.1952 21.0606 49.8541 19.6991 49.9393 18.2215C50.1098 15.1659 47.7613 12.5357 44.6997 12.3577C43.8858 12.3113 43.196 12.9302 43.1495 13.7425C43.103 14.5547 43.723 15.2432 44.5369 15.2896C45.9786 15.367 47.0947 16.6125 47.0094 18.0513C46.9707 18.7476 46.6607 19.3897 46.1336 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the U.S***. \n*\t***Geographical Expansion with Approvals of ADZYNMA® in EU and FRUZAQLA® in Japan ***\n*\t***Late-Stage Pipeline Advances with the Start of Phase 3 Trial of TAK-861 in Narcolepsy Type 1***\n*\t***Company will Hold R\u0026D Day for Investors and Media on December 12 (Eastern) / 13 (Japan) ***\n\n\n**OSAKA, Japan, October 31, 2024** – Takeda ([TSE:4502/NYSE:TAK](https://www.takeda.com/investors/stock-information/)) today announced earnings results for the first half of fiscal year 2024 (six months ended September 30, 2024), with continued momentum in its Growth \u0026 Launch Products driving growth. The company has upgraded its full year forecasts and Management Guidance to reflect stronger than anticipated first-half performance (including milder than anticipated generic erosion of VYVANSE® in the U.S.) and revised foreign exchange assumptions.\n\nThe strong performance of Takeda’s Growth and Launch Product portfolio, which grew 18.7% at CER and represented 47% of total revenue, reinforces the company’s confidence in returning to sustainable revenue and profit growth. \n\nThe initiation of TAK-861’s Phase 3 trial in August for narcolepsy type 1 demonstrates Takeda’s strength in advancing its promising late-stage pipeline to develop life-transforming treatments. More details on the company’s R\u0026D strategy and pipeline updates, including commercial prospects, will be presented at Takeda’s R\u0026D Day taking place on December 12 (EST) / 13 (JST), 2024. \n\n**Takeda chief executive officer, Christophe Weber, commented:**\n\n“In the first half of fiscal year 2024, we made further progress in advancing our pipeline, including the initiation of our TAK-861 Phase 3 trial for narcolepsy type 1. Our late-stage programs continue to advance, with several in Phase 3 development this fiscal year, and have the potential to transform the lives of patients around the world.\n\n“Our commercial execution has positioned us for sustainable growth despite a dynamic and competitive environment. Bolstered by the continued strong performance of our Growth \u0026 Launch Products, including a return to double-digit growth of ENTYVIO®, lifecycle management approvals and successful launches of new products such as FRUZAQLA® in our oncology portfolio, our business and long-term outlook remains strong.”\n\n**Takeda chief financial officer, Milano Furuta, commented:**\n\n“We are upgrading our FY2024 full year outlook, reflecting stronger than anticipated first half performance as well as updated foreign exchange assumptions for the year. Full year guidance reflects our intention to increase R\u0026D investment in the second half to support our late-stage pipeline. \n\n“We remain confident in delivering sustainable growth with our Growth \u0026 Launch Products and promising late-stage pipeline. Implementation of our multi-year program to improve our efficiency through organizational agility, procurement savings and data, digital and technology is progressing as planned. We continue to drive these initiatives to improve our Core Operating Profit Margin from FY2025 towards our low-to-mid 30s% target.”","visibleInListings":true,"title":"Takeda Announces Strong First Half FY2024 Results and Raises Full Year Outlook","slug":"/newsroom/newsreleases/2024/takeda-announces-strong-first-half-fy2024-results-and-raises-full-year-outlook","description":"Takeda announced strong earnings results for the first half of fiscal year 2024, with continued momentum in its Growth \u0026 Launch Products and advancements in its promising late-stage pipeline.","taxonomies":[{"__i18n_lang":"en","displayName":"Press Releases","language":"en","__metadata":{"key":"Taxonomy9451","modelName":"Taxonomy","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"Wr0KFDIza4E2fCgbz82Z9F","createdAt":"2022-12-08T10:11:40Z","updatedAt":"2024-07-18T14:23:21Z"},"type":"Taxonomy"}],"language":"en","__metadata":{"key":"Article9454","modelName":"Article","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"5e24bb86-b942-41c5-9c76-d6eaadfb03da","createdAt":"2024-10-29T06:49:23Z","updatedAt":"2024-10-31T06:00:05Z"},"type":"Article","featuredImg":{"created_by":{"id":"5c035dcf12017bdefe1298466d0c2f","type":"user"},"url":"http://assets-dam.takeda.com/image/upload/v1683892920/Global/OG%20Logo.jpg","metadata":{"epzciwdjuelllku8ngpo":["0001"]},"type":"cloudinary.asset","bytes":185717,"_version":1,"uploaded_by":{"id":"5c035dcf12017bdefe1298466d0c2f","type":"user"},"format":"jpg","version":1683892920,"created_at":"2023-05-12T12:02:00Z","height":627,"secure_url":"https://assets-dam.takeda.com/image/upload/v1683892920/Global/OG%20Logo.jpg","resource_type":"image","public_id":"Global/OG Logo","width":1200,"access_mode":"public","__metadata":{"key":"jdDRKJnyuW8qunA0HPL3m","modelName":"cloudinary.asset","projectId":"djvoabi3","source":"sourcebit-source-sanity"}}},{"publishDate":"2024-10-31T06:00:00.000Z","taxonomies":[{"displayName":"Press Releases","language":"en","__i18n_lang":"en","__metadata":{"key":"Taxonomy9452","modelName":"Taxonomy","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"Wr0KFDIza4E2fCgbz82Z9F","createdAt":"2022-12-08T10:11:40Z","updatedAt":"2024-07-18T14:23:21Z"},"type":"Taxonomy"}],"language":"en","title":"Notice of the Revised Forecast of Consolidated Financials for FY2024 (IFRS)","content":"**OSAKA, Japan, October 31, 2024** – Takeda ([TSE:4502/NYSE:TAK](/investors/overview/)) today announced the revised forecast of the full year consolidated financials for the fiscal year ending March 31, 2025 (FY2024), as below.\n\n1. Revised Forecast for Full Year Consolidated Financials for the Fiscal Year Ending March 31, 2025","slug":"/newsroom/newsreleases/2024/notice-of-the-revised-forecast-of-consolidated-financials-for-fy2024-ifrs","visibleInListings":true,"description":"OSAKA, Japan, October 31, 2024 – Takeda (TSE:4502/NYSE:TAK) today announced the revised forecast of the full year consolidated financials for the fiscal year ending March 31, 2025 (FY2024), as below.","__i18n_lang":"ja","__metadata":{"key":"Article9457","modelName":"Article","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"fd1fd28d-228d-4c5e-8bef-165faf94b23d","createdAt":"2024-10-29T00:07:43Z","updatedAt":"2024-10-31T06:00:22Z"},"type":"Article","featuredImg":{"created_by":{"id":"5c035dcf12017bdefe1298466d0c2f","type":"user"},"url":"http://assets-dam.takeda.com/image/upload/v1683892920/Global/OG%20Logo.jpg","metadata":{"epzciwdjuelllku8ngpo":["0001"]},"type":"cloudinary.asset","bytes":185717,"_version":1,"uploaded_by":{"id":"5c035dcf12017bdefe1298466d0c2f","type":"user"},"format":"jpg","version":1683892920,"created_at":"2023-05-12T12:02:00Z","height":627,"secure_url":"https://assets-dam.takeda.com/image/upload/v1683892920/Global/OG%20Logo.jpg","resource_type":"image","public_id":"Global/OG Logo","width":1200,"access_mode":"public","__metadata":{"key":"jdDRKJnyuW8qunA0HPL3m","modelName":"cloudinary.asset","projectId":"djvoabi3","source":"sourcebit-source-sanity"}}},{"language":"en","slug":"/newsroom/newsreleases/2024/first-half-fiscal-year-2024","description":"Takeda today announced that it will host its earnings call on Thursday, October 31, 2024, to present its 1st half financial results for fiscal year 2024.","title":" Takeda to Hold Earnings Call for Fiscal Year 2024 1st Half on October 31","publishDate":"2024-10-17T15:12:00.000Z","content":"**OSAKA, Japan, and CAMBRIDGE, Massachusetts, October 17, 2024** – Takeda ([TSE:4502/NYSE:TAK](https://www.takeda.com/investors/)) today announced that it will host its earnings call on Thursday, October 31, 2024, to present its 1st half results for fiscal year 2024. Details below:\n\n**Date/Time**: Thursday, October 31, 19:00-20:15 (JST) / 10:00-11:15 (GMT) / 06:00-07:15 (EDT)\n\n**Participants (planned):**\n\n* Christophe Weber, President and Chief Executive Officer\n* Milano Furuta, Chief Financial Officer\n* Andy Plump, President, Research \u0026 Development\n* Other executive leadership\n\n**Content:** Presentation, Q\u0026A session - presented in English and Japanese with simultaneous interpretation.\n\n**Webinar platform and registration**: The call will be held using the Zoom platform and Zoom simultaneous interpretation function. Kindly pre-register from the below link:\n\n[https://zoom.us/webinar/register/WN_PwdLT0NuTrWeZn-HsRIcaw](https://zoom.us/webinar/register/WN_PwdLT0NuTrWeZn-HsRIcaw)\n\nIf you wish to ask questions during the Q\u0026A session, please join from the above link.\n\n**Presentation material:** Presentation material will become available on [Takeda’s website](https://www.takeda.com/investors/financial-results/quarterly-results/) at 15:00 (JST) / 6:00 (GMT) / 2:00 (EDT) on Thursday, October 31st.\n\n**On-demand Replay:** An on-demand replay will be made available on [Takeda’s website](https://www.takeda.com/investors/financial-results/quarterly-results/) after the conclusion of the event.\n\n**Notes:** For optimal performance of simultaneous interpretation and raise-hand functions, please upgrade your Zoom application to the latest version [here](https://zoom.us/support/download).\n\n## About Takeda\n\nTakeda is focused on creating better health for people and a brighter future for the world. We aim to discover and deliver life-transforming treatments in our core therapeutic and business areas, including gastrointestinal and inflammation, rare diseases, plasma-derived therapies, oncology, neuroscience and vaccines. Together with our partners, we aim to improve the patient experience and advance a new frontier of treatment options through our dynamic and diverse pipeline. As a leading values-based, R\u0026D-driven biopharmaceutical company headquartered in Japan, we are guided by our commitment to patients, our people and the planet. Our employees in approximately 80 countries and regions are driven by our purpose and are grounded in the values that have defined us for more than two centuries. For more information, visit [www.takeda.com](http://www.takeda.com/).\n\n### Media Contacts:\n\nU.S., Japanese and International Media\n\nBrendan Jennings\n\n[brendan.jennings@takeda.com](mailto:brendan.jennings@takeda.com)\n\n\n## Important Notice\n\nFor the purposes of this notice, “press release” means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited (“Takeda”) regarding this press release. This press release (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this press release. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This press release is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws.\nThe companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, “Takeda” is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.\nThe product names appearing in this document are trademarks or registered trademarks owned by Takeda, or their respective owners.\n\n## Forward-Looking Statements\n\nThis press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda’s future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”, “aims”, “intends”, “ensures”, “will”, “may”, “should”, “would”, “could”, “anticipates”, “estimates”, “projects”, “forecasts”, “outlook” or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda’s global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic; the success of our environmental sustainability efforts, in enabling us to reduce our greenhouse gas emissions or meet our other environmental goals; the extent to which our efforts to increase efficiency, productivity or cost-savings, such as the integration of digital technologies, including artificial intelligence, in our business or other initiatives to restructure our operations will lead to the expected benefits; and other factors identified in Takeda’s most recent Annual Report on Form 20-F and Takeda’s other reports filed with the U.S. Securities and Exchange Commission, available on Takeda’s website at: [https://www.takeda.com/investors/sec-filings-and-security-reports/](https://www.takeda.com/investors/sec-filings-and-security-reports/)or at [www.sec.gov](http://www.sec.gov/). Takeda does not undertake to update any of the forward-looking statements contained in this press release or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this press release may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda’s future results.\n\n\n\n\n\n\n\n\n\n\n","taxonomies":[{"displayName":"Press Releases","language":"en","__i18n_lang":"en","__metadata":{"key":"Taxonomy9453","modelName":"Taxonomy","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"Wr0KFDIza4E2fCgbz82Z9F","createdAt":"2022-12-08T10:11:40Z","updatedAt":"2024-07-18T14:23:21Z"},"type":"Taxonomy"}],"visibleInListings":true,"__metadata":{"key":"Article9456","modelName":"Article","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"7d507252-1384-4cc8-9a98-332abae3659b","createdAt":"2024-10-11T15:10:18Z","updatedAt":"2024-10-17T13:02:33Z"},"type":"Article","featuredImg":{"created_by":{"id":"5c035dcf12017bdefe1298466d0c2f","type":"user"},"url":"http://assets-dam.takeda.com/image/upload/v1683892920/Global/OG%20Logo.jpg","metadata":{"epzciwdjuelllku8ngpo":["0001"]},"type":"cloudinary.asset","bytes":185717,"_version":1,"uploaded_by":{"id":"5c035dcf12017bdefe1298466d0c2f","type":"user"},"format":"jpg","version":1683892920,"created_at":"2023-05-12T12:02:00Z","height":627,"secure_url":"https://assets-dam.takeda.com/image/upload/v1683892920/Global/OG%20Logo.jpg","resource_type":"image","public_id":"Global/OG Logo","width":1200,"access_mode":"public","__metadata":{"key":"jdDRKJnyuW8qunA0HPL3m","modelName":"cloudinary.asset","projectId":"djvoabi3","source":"sourcebit-source-sanity"}}},{"publishDate":"2024-09-24T07:01:00.000Z","title":"Takeda Receives Approval for FRUZAQLA (fruquintinib) in Japan for the Treatment of Unresectable Advanced or Recurrent Colorectal Cancer","taxonomies":[{"language":"en","__i18n_lang":"en","displayName":"Press Releases","__metadata":{"key":"Taxonomy9455","modelName":"Taxonomy","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"Wr0KFDIza4E2fCgbz82Z9F","createdAt":"2022-12-08T10:11:40Z","updatedAt":"2024-07-18T14:23:21Z"},"type":"Taxonomy"}],"slug":"/newsroom/newsreleases/2024/takeda-receives-approval-for-fruzaqla-in-japan-for-the-treatment-of-unresectable-advanced-or-recurrent-colorectal-cancer","description":"Takeda announces Japanese Ministry of Health approval for FRUZAQLA (fruquintinib) to treat unresectable advanced or recurrent colorectal cancer, based on positive Phase 3 FRESCO-2 trial results.","content":"* ***Approval Based on Results from Positive, Global, Phase 3 FRESCO-2 Trial***\n\n* ***FRUZAQLA (fruquintinib) is the First Novel Targeted Therapy in Japan for Metastatic Colorectal Cancer (mCRC) Regardless of Biomarker Status in Over a Decade***\n\n**OSAKA, Japan and CAMBRIDGE, Massachusetts, September 24, 2024** – Takeda ([TSE:4502/NYSE:TAK](https://cts.businesswire.com/ct/CT?id=smartlink\\\u0026url=https%3A%2F%2Fwww.takeda.com%2Finvestors%2F\\\u0026esheet=52286207\\\u0026newsitemid=20200915005224\\\u0026lan=en-US\\\u0026anchor=TSE%3A4502%2FNYSE%3ATAK\\\u0026index=2\\\u0026md5=b7076f2bbb02ad331cdf76657f8aa07f)) today announced that it has received approval from the Japanese Ministry of Health, Labour and Welfare to manufacture and market FRUZAQLA Capsules 1mg/5mg (generic name: fruquintinib), a selective oral inhibitor of vascular endothelial growth factor receptor (VEGFR) -1, -2 and -3, for the treatment of advanced or recurrent colorectal cancer (CRC) that is neither curable nor resectable and that has progressed after chemotherapy.\n\nThe approval is based primarily on the results of the FRESCO-2 trial, a global Phase 3 clinical trial conducted in the United States, Europe, Japan and Australia. The trial compared FRUZAQLA plus best supportive care (BSC) with placebo plus BSC in patients with previously treated metastatic colorectal cancer (mCRC). The FRESCO-2 trial met all primary and key secondary efficacy endpoints and demonstrated consistent benefits in patients who received FRUZAQLA, regardless of the types of therapy the patients had previously received. FRUZAQLA demonstrated a manageable safety profile in the FRESCO-2 trial, with the incidence of adverse events leading to discontinuation being 21% in the placebo plus BSC arm compared to 20% in the FRUZAQLA plus BSC arm.\u003csup\u003e1\u003c/sup\u003e The data from the FRESCO-2 trial were [published](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736\$23\$00772-9/abstract) in The Lancet in June 2023.\n\nDr. Takayuki Yoshino, deputy director of hospital, head, Division for the Promotion of Drug and Diagnostic Development, and chief, Department of Gastrointestinal Oncology at the National Cancer Center Hospital East, who served on the FRESCO-2 study Steering Committee, said, “Although the mortality rate of colorectal cancer has been going down in recent years due to early screening and advances in treatment, the 5-year survival rate for metastatic colorectal cancer remains low and new treatment options are much in need. The approval of FRUZAQLA in Japan offers new hope for patients and families of patients with metastatic colorectal cancer, as well as for healthcare personnel involved in colorectal cancer treatment. I feel that it is of great clinical significance.”\n\n“For more than a decade, Takeda has been a leader in advancing the treatment of metastatic colorectal cancer in Japan. With this approval of FRUZAQLA, we are able to further support patients living with this debilitating disease,” said Teresa Bitetti, president of the Global Oncology Business Unit at Takeda. “FRUZAQLA is now approved in the U.S., European Union, Japan and a number of other countries around the world, and we remain committed to bringing this treatment to additional patients with metastatic colorectal cancer around the world who urgently need new therapeutic options.”\n\n## About FRUZAQLA (fruquintinib)\n\nFRUZAQLA is a selective oral inhibitor of all three VEGF receptors (-1, -2 and -3). VEGFR inhibitors play a pivotal role in blocking tumor angiogenesis. FRUZAQLA was designed to have enhanced selectivity that limits off-target kinase activity, allowing for drug exposure achieving sustained target inhibition and flexibility for potential use as part of combination therapy.\n\nTakeda has the exclusive worldwide license to further develop, commercialize, and manufacture fruquintinib outside of mainland China, Hong Kong and Macau. FRUZAQLA was approved by the U.S. Food and Drug Administration (FDA) in November 2023 and by the European Commission (EC) in June 2024. Fruquintinib is developed and marketed in China by HUTCHMED. Fruquintinib was approved for marketing by the China National Medical Products Administration (NMPA) in September 2018 and commercially launched in China in November 2018 under the brand name ELUNATE®.\n\n## JAPAN IMPORTANT SAFETY INFORMATION\n\nPlease consult the FRUZAQLA (fruquintinib) Japan package insert (J-PI) before prescribing.\n\n**WARNING:** FRUZAQLA should be administered only to patients for whom the use of FRUZAQLA is considered appropriate under the supervision of a physician with sufficient knowledge of and experience in cancer chemotherapy at a medical institution where adequate emergency care can be provided. Prior to treatment initiation, the efficacy and risks should be fully explained to the patient and/or his/her family and informed consent should be obtained; Severe gastrointestinal hemorrhage, including fatal cases, has been reported. Patients should be carefully monitored, and if any abnormalities are observed, administration of FRUZAQLA should be withheld and appropriate measures should be taken. If severe hemorrhage occurs, FRUZAQLA should not be re-administered; Gastrointestinal perforation has been reported with some fatal cases. Patients should be carefully monitored, and if any abnormalities are observed, administration of FRUZAQLA should be withheld and appropriate measures should be taken. If gastrointestinal perforation occurs, FRUZAQLA should not be re-administered.\n\n**CONTRAINDICATIONS:** Patients with a history of hypersensitivity to any of the ingredients of FRUZAQLA.\n\n**IMPORTANT PRECAUTIONS:** Hypertension, including hypertensive crisis, may occur. Blood pressure should be measured prior to the initiation of FRUZAQLA treatment and periodically during this treatment; Proteinuria may occur. Urinary protein should be monitored prior to the initiation of FRUZAQLA treatment and periodically during this treatment; If a surgical procedure is to be performed, patients are recommended to withhold FRUZAQLA before the surgery because wound healing may be delayed. Treatment resumption after the surgical procedure should be determined depending on the patient's condition upon confirmation of adequate wound healing.\n\n**PRECAUTIONS CONCERNING PATIENTS WITH SPECIFIC BACKGROUNDS: Patients with hypertension:** Hypertension may worsen; **Patients with bleeding diathesis or abnormal coagulation system:** Hemorrhagic events may occur; **Patients with hemorrhage such as gastrointestinal hemorrhage:** Hemorrhage may be enhanced; **Patients with a complication of intra-abdominal inflammation in the gastrointestinal tract, etc.:** Gastrointestinal perforation may occur; **Patients with current or a history of thromboembolism:** Transient ischaemic attack, thrombotic microangiopathy, pulmonary embolism, portal vein thrombosis, deep vein thrombosis, etc. may occur; **Patients with severe hepatic impairment (Child-Pugh Class C):** Since FRUZAQLA is metabolized mainly in the liver, blood concentrations may be increased. There have been no clinical studies conducted in patients with severe hepatic impairment; **Patients with Reproductive Potential:** Women of childbearing potential should be advised to use adequate contraception during treatment with FRUZAQLA and for 2 weeks after the last dose; **Pregnant Women:** FRUZAQLA can be administered to women who are or may be pregnant only if the expected therapeutic benefits outweigh the possible risks associated with this treatment. In a rat embryo-fetal toxicity study, fetal abnormalities and teratogenic effects consisting of fetal external, visceral, and skeletal malformations and visceral and skeletal variations were observed at exposure levels approximately 0.05 times the exposure level (AUC) of FRUZAQLA at the maximum clinical dose (5 mg/day); **Breast-feeding Women:** It is advisable not to breastfeed. FRUZAQLA may pass into breast milk, and infants may experience serious adverse reactions if they are ingested through breast milk; **Pediatric Use:** There have been no clinical studies conducted in pediatric patients.\n\n## ADVERSE REACTIONS:\n\nAny of the adverse reactions listed below may occur. Patients should be closely monitored, and if any such abnormalities are observed, appropriate measures should be taken, including treatment discontinuation. Clinically Significant Adverse Reactions are follows.\n\n**Hypertension:** Hypertension or hypertensive crisis may occur. If an increase in blood pressure is observed, appropriate treatment such as antihypertensive drug administration should be given as necessary, and if necessary, the dose of fruquintinib should be reduced, or fruquintinib administration should be interrupted. If severe or persistent hypertension, or hypertension that cannot be controlled by routine antihypertensive therapy occurs or if a hypertensive crisis occurs, fruquintinib administration should be discontinued; **Skin disorder:** Skin disorder including palmar-plantar erythrodysesthesia syndrome and rash may occur; **Hemorrhage:** Hemorrhage including epistaxis, hematuria, gastrointestinal hemorrhage and hemoptysis may occur. Fatal outcomes have been reported; **Gastrointestinal perforation:** Fatal outcomes have been reported; **Arterial thromboembolic events:** Arterial thromboembolic events including transient ischemic attack and thrombotic microangiopathy may occur; **Venous thromboembolism events:** Venous thromboembolism such as pulmonary embolism, portal vein thrombosis, and deep vein thrombosis may occur; **Posterior reversible encephalopathy syndrome:** If headaches, convulsions, lethargy, confusion, changes in mental function, blindness or other visual disturbances, or neurological impairment are observed, fruquintinib administration should be discontinued, and appropriate measures should be taken, including blood pressure control; **Arterial dissection:** Arterial dissection including aortic dissection may occur.\n\n**For US Prescribing Information:** \u003chttps://www.fruzaqla.com/sites/default/files/resources/fruzaqla-prescribing-information.pdf\u003e\n\n**For European Union Summary of Product Characteristics:** \u003chttps://www.ema.europa.eu/en/medicines/human/EPAR/fruzaqla\u003e\n\n## About the Phase 3 FRESCO-2 Trial\n\nThe FRESCO-2 study is a multi-regional clinical trial conducted in the U.S., Europe, Japan and Australia investigating FRUZAQLA plus BSC vs placebo plus BSC in patients with previously treated mCRC ([NCT04322539](https://clinicaltrials.gov/study/NCT04322539)). The study met all of its primary and key secondary endpoints, demonstrating that treatment with FRUZAQLA resulted in statistically significant and clinically meaningful improvement in overall survival and progression-free survival. The safety profile of FRUZAQLA in FRESCO-2 was consistent with previously reported fruquintinib monotherapy studies. Results from the study were [presented](https://oncologypro.esmo.org/meeting-resources/esmo-congress-2022/fresco-2-a-global-phase-iii-multiregional-clinical-trial-mrct-evaluating-the-efficacy-and-safety-of-fruquintinib-in-patients-with-refractory-met) at ESMO in September 2022 and subsequently [published](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736\$23\$00772-9/abstract) in *The Lancet* in June 2023.\u003csup\u003e2,1\u003c/sup\u003e\n\n## Takeda’s Commitment to Colorectal Cancer in Japan\n\nCRC is the most prevalent type of cancer in Japan, with an estimated 161,000 new cases and 54,000 deaths in 2023, according to the National Cancer Center’s statistics.\u003csup\u003e3\u003c/sup\u003e While early-stage CRC can be surgically resected, mCRC remains an area of high unmet need with patients awaiting new treatment options, given its poor prognosis and limited treatment options.\u003csup\u003e4-8 \u003c/sup\u003eFor over a decade, we have contributed to the treatment of patients with late-stage CRC who have limited treatment options and to the advancement of personalized treatment through the provision of innovative medicines and the generation of relevant evidence. Moving forward, we will continue our work to treat patients with CRC and address their unmet needs.\n\n## About Takeda\n\nTakeda is focused on creating better health for people and a brighter future for the world. We aim to discover and deliver life-transforming treatments in our core therapeutic and business areas, including gastrointestinal and inflammation, rare diseases, plasma-derived therapies, oncology, neuroscience and vaccines. Together with our partners, we aim to improve the patient experience and advance a new frontier of treatment options through our dynamic and diverse pipeline. As a leading values-based, R\\\u0026D-driven biopharmaceutical company headquartered in Japan, we are guided by our commitment to patients, our people and the planet. Our employees in approximately 80 countries and regions are driven by our purpose and are grounded in the values that have defined us for more than two centuries. For more information, visit [www.takeda.com](http://www.takeda.com).\n\n## Media Contacts:\n\n**Japanese Media**\n\nAkiko Manome\n\n\u003cakiko.manome@takeda.com\u003e\n\n**U.S. and International Media**\n\nEmma Nash\n\n\u003cemma.nash@takeda.com\u003e\n\n## Important Notice\n\nFor the purposes of this notice, “press release” means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited (“Takeda”) regarding this release. This press release (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this press release. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This press release is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws.\n\nThe companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, “Takeda” is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.\n\n## Forward-Looking Statements\n\nThis press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda’s future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”, “aims”, “intends”, “ensures”, “will”, “may”, “should”, “would”, “could”, “anticipates”, “estimates”, “projects” or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda’s global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations, including global health care reforms; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic, on Takeda and its customers and suppliers, including foreign governments in countries in which Takeda operates, or on other facets of its business; the timing and impact of post-merger integration efforts with acquired companies; the ability to divest assets that are not core to Takeda’s operations and the timing of any such divestment(s); and other factors identified in Takeda’s most recent Annual Report on Form 20-F and Takeda’s other reports filed with the U.S. Securities and Exchange Commission, available on Takeda’s website at: \u003chttps://www.takeda.com/investors/sec-filings-and-security-reports/\u003e or at [www.sec.gov](http://www.sec.gov). Takeda does not undertake to update any of the forward-looking statements contained in this press release or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this press release may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda’s future results.\n\n## Medical Information\n\nThis press release contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.\n\n## References:\n\n1. Dasari NA, et al. Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study. Lancet. 2023;402(10395):41-53. doi:10.1016/S0140-6736(23)00772-9.\n2. Dasari NA, et al. LBA25 – FRESCO-2: A global phase 3 multiregional clinical trial (MRCT) evaluating the efficacy and safety of fruquintinib in patients with refractory metastatic colorectal cancer. Ann Oncol. 2022 Sep;33(suppl\\_7): S808-S869. Doi:10.1016/annonc/annonc1089.\n3. Foundation for Promotion of Cancer Research. Cancer Statistics In Japan. Tokyo, Foundation for Promotion of Cancer Research; 2023.\n4. Bando H, et al. Therapeutic landscape and future direction of metastatic colorectal cancer. Nat Rev Gastroenterol Hepatol 2023; 20(5)306-322. doi:10.1038/s41575-022-00736-1.\n5. D'Haene N, et al. Clinical application of targeted next-generation sequencing for colorectal cancer patients: a multicentric Belgian experience. Oncotarget. 2018;9(29):20761-20768. Published 2018 Apr 17. doi:10.18632/oncotarget.25099.\n6. Venderbosch, et al. Mismatch repair status and braf mutation status in metastatic colorectal cancer patients: A pooled analysis of the Cairo, Cairo2, coin, and Focus Studies. Clinical Cancer Res.,2014; 20(20):5322–5330. doi:10.1158/1078-0432.ccr-14-0332.\n7. Koopman, M., et al. Deficient mismatch repair system in patients with sporadic advanced colorectal cancer. Br J Cancer. 209;100(2), 266–273. doi:10.1038/sj.bjc.6604867.\n8. Ahcene Djaballah S, et al. HER2 in Colorectal Cancer: The Long and Winding Road From Negative Predictive Factor to Positive Actionable Target.Am Soc Clin Oncol Educ Book. 2022;42:1-14. doi:10.1200/EDBK\\_351354.\n\n","visibleInListings":true,"language":"en","__metadata":{"key":"Article9458","modelName":"Article","projectId":"djvoabi3","source":"sourcebit-source-sanity","id":"uoqN7NEmDNzkGmZZxRQfWu","createdAt":"2024-09-11T00:49:39Z","updatedAt":"2024-09-24T14:36:58Z"},"type":"Article","featuredImg":{"created_by":{"id":"5c035dcf12017bdefe1298466d0c2f","type":"user"},"url":"http://assets-dam.takeda.com/image/upload/v1683892920/Global/OG%20Logo.jpg","metadata":{"epzciwdjuelllku8ngpo":["0001"]},"type":"cloudinary.asset","bytes":185717,"_version":1,"uploaded_by":{"id":"5c035dcf12017bdefe1298466d0c2f","type":"user"},"format":"jpg","version":1683892920,"created_at":"2023-05-12T12:02:00Z","height":627,"secure_url":"https://assets-dam.takeda.com/image/upload/v1683892920/Global/OG%20Logo.jpg","resource_type":"image","public_id":"Global/OG Logo","width":1200,"access_mode":"public","__metadata":{"key":"jdDRKJnyuW8qunA0HPL3m","modelName":"cloudinary.asset","projectId":"djvoabi3","source":"sourcebit-source-sanity"}}}]},{"subtitle":"We exist to create better health for people and a brighter future for the world. 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