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James, PhD Accurate Lung Shunt Fraction (LSF) is essential for safe Yttrium-90 (Y90) radioembolization (TARE) treatment of Hepatocellular Carcinoma (HCC) in patients with ascites. 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James, PhD Accurate Lung Shunt Fraction (LSF) is essential for safe Yttrium-90 (Y90) radioembolization (TARE) treatment of Hepatocellular Carcinoma (HCC) in patients with ascites. 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format-standard has-post-thumbnail hentry category-home-articles category-v8n1"> <header class="entry-header clearfix"> <h1 class="entry-title">A Cases Series of Discrepancies in Lung Shunt Fraction Calculation Between 2D Planar and 3D Single Photon Emission Computed Tomography Imaging for Y-90 Radioembolization in Hepatocellular Carcinoma Patients with Ascites</h1> </header> <div class="entry-thumbnail"> <img width="777" height="437" src="https://medimagingcasereports.com/wp-content/uploads/sites/8/2024/08/Figure-1-777x437.jpg" class="attachment-content-single wp-post-image" alt="Figure 1"/></div> <p class="entry-meta"> </p> <div class="entry-content clearfix"> <div class="italics"><i> Paula Gamero Kubota, MD, Robert Wagner, MD, Christopher Molvar, MD, James Halama, PhD and Judy R. James, PhD</i></div> <div class="italics"></div> <div class="italics"></div> <div></div> <div></div> <div> <p><strong>Abstract</strong></p> <p style="text-align: justify;">Accurate lung shunt fraction (LSF) is essential for safe Yttrium-90 (Y-90) transarterial radioembolization (TARE) treatment of hepatocellular carcinoma (HCC) in patients with ascites. However, traditional 2D imaging might be inaccurate for LSF calculation in this population. This study compared 2D planar imaging with 3D single photon emission computed tomography (SPECT) for LSF calculation in HCC patients with ascites undergoing TARE. Significant discrepancies were found between 2D and 3D SPECT LSF measurements, suggesting potential overestimation with 2D imaging. 3D SPECT offers a more precise method for LSF calculation in HCC patients with ascites, potentially leading to safer and more effective TARE treatment with higher Y-90 doses.</p> <p><strong>Published on:</strong> August 09, 2024<br/> <strong>doi:</strong> <a href="https://doi.org/10.17756/micr.2024-105" onclick="__gaTracker('send', 'event', 'outbound-article', 'https://doi.org/10.17756/micr.2024-105', '10.17756/micr.2024-105');">10.17756/micr.2024-105</a></p> <p><strong>Citation: </strong> Kubota PG, Wagner R, Molvar C, Halama J, James JR. 2024. A Cases Series of Discrepancies in Lung Shunt Fraction Calculation Between 2D Planar and 3D Single Photon Emission Computed Tomography Imaging for Y-90 Radioembolization in Hepatocellular Carcinoma Patients with Ascites. <i>J Med Imaging Case Rep</i> 8(1): 18-22.</p> <div> <div class="pdfdownloadlink"><img class="alignleft size-full wp-image-507" style="margin: 4px -5px 4px 5px;" src="http://jnanoworld.com/wp-content/uploads/2017/04/pdf-icon-24-e1509106685135-1.png" alt="" width="16" height="16"/><div class="sdm_download_link"><a href="https://medimagingcasereports.com/?smd_process_download=1&download_id=2064" class="sdm_download green" title="micr-105-judy-r-james.pdf" target="_self">PDF (Download Full text)</a></div></div> <div> <p><div class="sdm_download_count"><span class="sdm_count_number"><strong>106</strong></span><br/><span class="sdm_count_string"> Downloads</span></div><span class="postviews_eachpost"><div class="post-views post-2062 entry-meta"> <span 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