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style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Dr Kishori Apte</h3></div><div class="js-work-strip profile--work_container" data-work-id="121682112"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682112/_i_Cassia_auriculata_i_Aspects_of_Safety_Pharmacology_and_Drug_Interaction"><img alt="Research paper thumbnail of <i>Cassia auriculata</i>: Aspects of Safety Pharmacology and Drug Interaction" class="work-thumbnail" src="https://attachments.academia-assets.com/116504656/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682112/_i_Cassia_auriculata_i_Aspects_of_Safety_Pharmacology_and_Drug_Interaction"><i>Cassia auriculata</i>: Aspects of Safety Pharmacology and Drug Interaction</a></div><div class="wp-workCard_item"><span>Evidence-based Complementary and Alternative Medicine</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried ou...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-based supercritical extract of Cassia auriculata for 12 weeks. Our studies indicate that both these extracts are pharmacologically safe and did not show any significant adverse reactions at the tested doses. The traditional hydro-alcoholic extract did not show any significant effect on pharmacokinetics; however, the technology-based supercritical extract caused a significant reduction in absorption of metformin. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682111"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682111/Synthesis_Biological_Activity_Molecular_Modelling_Studies_and_3D_QSARInvestigations_of_N_2_aryl_substituted_aryl_4_oxo_1_3_thiazolidin_3_yl_pyridine_4_carboxamides"><img alt="Research paper thumbnail of Synthesis, Biological Activity, Molecular Modelling Studies and 3D-QSARInvestigations of N-[2-(aryl/substituted aryl)-4-oxo-1, 3-thiazolidin-3-yl]pyridine-4-carboxamides" class="work-thumbnail" src="https://attachments.academia-assets.com/116504655/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682111/Synthesis_Biological_Activity_Molecular_Modelling_Studies_and_3D_QSARInvestigations_of_N_2_aryl_substituted_aryl_4_oxo_1_3_thiazolidin_3_yl_pyridine_4_carboxamides">Synthesis, Biological Activity, Molecular Modelling Studies and 3D-QSARInvestigations of N-[2-(aryl/substituted aryl)-4-oxo-1, 3-thiazolidin-3-yl]pyridine-4-carboxamides</a></div><div class="wp-workCard_item"><span>The open conference proceedings journal</span><span>, Dec 13, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the present research work new 4-thiazolidinones possessing dual cyclooxygenase/lipoxygenase in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the present research work new 4-thiazolidinones possessing dual cyclooxygenase/lipoxygenase inhibition were synthesized. Sixteen N-[2-(aryl/substitutedaryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide derivatives(5a-q) differing by the phenyl group substitution were synthesized by sonication. Compounds N-[2-(4-chlorophenyl)-4-oxo-1, 3thiazolidin-3-yl] pyridine-4-carboxamide (5d) and N-[2-(4-nitrophenyl)-4-oxo-1, 3-thiazolidin-3-yl] pyridine-4-carboxamide (5f) showed promising anti-inflammatory activity investigated by the carrageenan induced edema model in rats. Compound 5f, was the most active in the series with low ulcerogenic index and good safety profile with highest in vitro inhibition of COX-1/COX-2 (89.28; 52.80%, p<0.01) with 27.36% inhibition of 15-LOX. Compounds 5d and 5f, at the dose of 100mg/kg p.o. were also effective in lowering the elevated levels of AST, ALT and ALP in serum and also lowered the elevated levels of MPO in edematous tissue comparable to standard anti-inflammatory drug, Indomethacin. The Autodock investigation of the synthesized compounds within the COX and LOX enzymes predicted fairly good correlation between the anti-inflammatory activities (IC 50) and their binding affinities. The 3D-QSAR studies (V-Life Molecular Design Software) of the synthesized 4-thiazolidinones for their anti-inflammatory activity by the developed kNN, PLRS and MLR models suggested that presence of electron withdrawing functional groups like-NO 2,-Cl on the phenyl ring were favourable for activity. The results of the present study may help to identify the relative positions and ranges of important electrostatic and steric fields at various positions around the pharmacophore that could be useful in the design of new molecules with improved anti-inflammatory activity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b2a75ba61809fbee969072fcd0124a5e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504655,"asset_id":121682111,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504655/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682111"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682111"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682111; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682111]").text(description); $(".js-view-count[data-work-id=121682111]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121682111; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121682111']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682110"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682110/Medicinal_Plants_as_Potential_Source_of_Anticancer_Agents_A_Review"><img alt="Research paper thumbnail of Medicinal Plants as Potential Source of Anticancer Agents: A Review" class="work-thumbnail" src="https://attachments.academia-assets.com/116504625/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682110/Medicinal_Plants_as_Potential_Source_of_Anticancer_Agents_A_Review">Medicinal Plants as Potential Source of Anticancer Agents: A Review</a></div><div class="wp-workCard_item"><span>Journal of Pharmacognosy and Phytochemistry</span><span>, Mar 1, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cancer is a major public health burden in both developed and developing countries. Anticancer act...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cancer is a major public health burden in both developed and developing countries. Anticancer activity is the effect of natural and synthetic or biological and chemical agents to reverse, suppress or prevent carcinogenic progression. Several synthetic agents are used to cure the disease but they have their toxicity and hence the research is going on to investigate the plant derived chemotherapeutic agents. Therefore an attempt has been made to review some medicinal plants having anticancer properties. In this review, anticancer medicinal plants of Indian origin belonging to various families are reported along with detailed information. All these plants are potential candidates for advanced studies since they are showing good anticancer activity. The present paper is a comprehensive review of different literature sources. It will be helpful to explore the medicinal value of the plants against the cancer and for the new drug discovery from them for the researchers and scientists around the world.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e23eea209ce3db4d330b96743bd01077" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504625,"asset_id":121682110,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504625/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682110"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682110"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682110; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682109"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682109/Haematological_Profile_in_Chronically_Undernourished_Thrifty_Rats_at_28_Days_of_Age"><img alt="Research paper thumbnail of Haematological Profile in Chronically Undernourished Thrifty Rats at 28 Days of Age" class="work-thumbnail" src="https://attachments.academia-assets.com/116504623/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682109/Haematological_Profile_in_Chronically_Undernourished_Thrifty_Rats_at_28_Days_of_Age">Haematological Profile in Chronically Undernourished Thrifty Rats at 28 Days of Age</a></div><div class="wp-workCard_item"><span>International journal of scientific research</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Foetal programming due to undernutrition is a known risk factor for the worldwide epidemic of Typ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Foetal programming due to undernutrition is a known risk factor for the worldwide epidemic of Type 2 diabetes and cardiovascular disease.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b339345e74e31d048b0273d6c5a943b4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504623,"asset_id":121682109,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504623/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682109"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682109"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682109; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682108"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/121682108/The_study_of_antifertility_effect_of_seeds_of_Crotalaria_juncea_Linn"><img alt="Research paper thumbnail of The study of antifertility effect of seeds of Crotalaria juncea Linn" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/121682108/The_study_of_antifertility_effect_of_seeds_of_Crotalaria_juncea_Linn">The study of antifertility effect of seeds of Crotalaria juncea Linn</a></div><div class="wp-workCard_item"><span>Shodhganga</span><span>, 1991</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682108"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682108"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682108; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682108]").text(description); $(".js-view-count[data-work-id=121682108]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121682108; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121682108']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=121682108]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121682108,"title":"The study of antifertility effect of seeds of Crotalaria juncea Linn","internal_url":"https://www.academia.edu/121682108/The_study_of_antifertility_effect_of_seeds_of_Crotalaria_juncea_Linn","owner_id":199490985,"coauthors_can_edit":true,"owner":{"id":199490985,"first_name":"Dr Kishori","middle_initials":null,"last_name":"Apte","page_name":"DrKishoriApte","domain_name":"independent","created_at":"2021-07-27T02:27:43.567-07:00","display_name":"Dr Kishori Apte","url":"https://independent.academia.edu/DrKishoriApte"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682107"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/121682107/In_Vitro_Screening_of_Some_Medicinal_Plants_on_Breast_Ovary_and_Colon_Cancer_Cell_Lines"><img alt="Research paper thumbnail of In-Vitro Screening of Some Medicinal Plants on Breast, Ovary and Colon Cancer Cell Lines" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/121682107/In_Vitro_Screening_of_Some_Medicinal_Plants_on_Breast_Ovary_and_Colon_Cancer_Cell_Lines">In-Vitro Screening of Some Medicinal Plants on Breast, Ovary and Colon Cancer Cell Lines</a></div><div class="wp-workCard_item"><span>International journal of pharma and bio sciences</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the present study, the aqueous extracts of Curcum caesia, Curcuma longa, Curcuma zedoaria and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the present study, the aqueous extracts of Curcum caesia, Curcuma longa, Curcuma zedoaria and Gloriosa superba was studied for their in vitro cytotoxic activity against human breast cancer (MCF-7), colon cancer (HCT-116) and ovarian cancer (PA-1) cell lines using sulphorhodamine B (SRB) assay. The results showed that aqueous extract of Curcuma zedoaria and Gloriosa superba exhibited the prominent inhibitory effect whereas Curcuma longa and Curcuma caesia have moderate to weak effects in in vitro conditions as compared with standard drug 5-fluorouracil.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682107"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682107"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682107; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682107]").text(description); $(".js-view-count[data-work-id=121682107]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121682107; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121682107']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=121682107]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121682107,"title":"In-Vitro Screening of Some Medicinal Plants on Breast, Ovary and Colon Cancer Cell Lines","internal_url":"https://www.academia.edu/121682107/In_Vitro_Screening_of_Some_Medicinal_Plants_on_Breast_Ovary_and_Colon_Cancer_Cell_Lines","owner_id":199490985,"coauthors_can_edit":true,"owner":{"id":199490985,"first_name":"Dr Kishori","middle_initials":null,"last_name":"Apte","page_name":"DrKishoriApte","domain_name":"independent","created_at":"2021-07-27T02:27:43.567-07:00","display_name":"Dr Kishori Apte","url":"https://independent.academia.edu/DrKishoriApte"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682106"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682106/Role_of_Adiantum_philippense_L_on_glucose_uptake_in_isolated_pancreatic_cells_and_inhibition_of_adipocyte_differentiation_in_3T3_L1_cell_line"><img alt="Research paper thumbnail of Role of Adiantum philippense L. on glucose uptake in isolated pancreatic cells and inhibition of adipocyte differentiation in 3T3-L1 cell line" class="work-thumbnail" src="https://attachments.academia-assets.com/116504654/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682106/Role_of_Adiantum_philippense_L_on_glucose_uptake_in_isolated_pancreatic_cells_and_inhibition_of_adipocyte_differentiation_in_3T3_L1_cell_line">Role of Adiantum philippense L. on glucose uptake in isolated pancreatic cells and inhibition of adipocyte differentiation in 3T3-L1 cell line</a></div><div class="wp-workCard_item"><span>Pharmacognosy Magazine</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Adiantum philippense (AP) is a pteridophyte that shows antihyperglycemic activity in ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Adiantum philippense (AP) is a pteridophyte that shows antihyperglycemic activity in vivo diabetic model, but the mechanism of action is unknown. Objective: AP was found to play a pivotal role in minimizing the high blood glucose in alloxan-induced diabetic rats. Simultaneously, it was observed that it could maintain the normal lipid profile even in diabetic condition. To investigate its insulin-like activity along with its inhibitory role on adipocyte differentiation became the objective of our present study. Materials and Methods: Glucose uptake potential of this fern was done in isolated pancreatic islets and inhibition of adipocyte differentiation was assessed in 3T3-L1 cell line. Before this, the cytotoxic concentration was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on L929 cell line. To determine its role in lipid metabolism, the oil droplets produced in adipocytes were stained with Oil 'O' red staining, and triglyceride levels of various drug treatments were measured spectrophotometrically. Results: This fern extract was found to be actively utilizing glucose in the glucose uptake assay. Moreover, it was also involved in inhibiting differentiation of pro-adipocyte to adipocyte in the 3T3-L1 cell lines. The percentage inhibition as obtained from the absorbance showed that the ethanolic extract at the concentration of 200 µg/ml showed 32.48% inhibition. Conclusion: All the above-mentioned parameters when appraised indicated that this fern could be used as an alternative medicine in managing diabetes associated with obesity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1e22d4349f46d14931a08dde2b474f88" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504654,"asset_id":121682106,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504654/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682106"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682106"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682106; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682105"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682105/Comparative_Anticancer_Evaluation_of_Curcuma_zedoaria_and_Gloriosa_superba_against_7_12_Dimethylbenz_a_anthracene_DMBA_Induced_Mammary_Tumors_in_Rats"><img alt="Research paper thumbnail of Comparative Anticancer Evaluation of Curcuma zedoaria and Gloriosa superba against 7, 12-Dimethylbenz [a] anthracene (DMBA) Induced Mammary Tumors in Rats" class="work-thumbnail" src="https://attachments.academia-assets.com/116504620/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682105/Comparative_Anticancer_Evaluation_of_Curcuma_zedoaria_and_Gloriosa_superba_against_7_12_Dimethylbenz_a_anthracene_DMBA_Induced_Mammary_Tumors_in_Rats">Comparative Anticancer Evaluation of Curcuma zedoaria and Gloriosa superba against 7, 12-Dimethylbenz [a] anthracene (DMBA) Induced Mammary Tumors in Rats</a></div><div class="wp-workCard_item"><span>Journal of current pharma research</span><span>, Nov 15, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this study tumors were developed with carcinogenic agent 7-12 Dimethylbenz[a] anthracene (DMBA...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this study tumors were developed with carcinogenic agent 7-12 Dimethylbenz[a] anthracene (DMBA) in female albino wistar rats at a dose of 7.5 mg/kg sc. once in a week for 4 weeks and waited for 90 days considering from first day of initiation until development of tumors. Once tumors were developed at 90 days then tumor size was measured weekly with digital vernier caliper for four weeks during the treatment of plant extracts. Plant extracts of Curcuma zedoaria and Gloriosa superba comparatively evaluated for their potential to reduce tumor size against Paclitaxel. Administration of aqueous extracts of Curcuma zedoaria and Gloriosa superba at dose of 5mg/kg body weight orally for 30 days was associated with significant decrease in tumor volume as compare to that of Paclitaxel which was given at dose of 1mg/kg body weight i.p. Apart from this Curcuma zedoaria and Gloriosa superba aqueous plants extracts treated groups has shown significant down regulation of biological markers like SGPT, ALP, LDH, LPO, Urea, and up regulation of GSH, Total protein. Therefore Curcuma zedoaria and Gloriosa superba when administered orally can act as effective curative agent towards DMBA induced mammary tumors.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e38993a7144abecdfd1a9718801198c4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504620,"asset_id":121682105,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504620/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682105"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682105"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682105; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682103"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682103/Anti_Diabetic_potential_of_a_polyherbal_formulation_A_review"><img alt="Research paper thumbnail of Anti-Diabetic potential of a polyherbal formulation-A review" class="work-thumbnail" src="https://attachments.academia-assets.com/116504658/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682103/Anti_Diabetic_potential_of_a_polyherbal_formulation_A_review">Anti-Diabetic potential of a polyherbal formulation-A review</a></div><div class="wp-workCard_item"><span>Research Journal of Pharmacy and Technology</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aim: The present study was aimed to design the effect of poly herbal formulation against alloxan ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aim: The present study was aimed to design the effect of poly herbal formulation against alloxan induced diabetic rats. The formulation was prepared by using three common herbal plants namely Alternanthera sessilis Linn., Amaranthus viridis Linn., and Boerhavia diffusa Linn., and glibenclamide as a standard. Methods: The rats were divided in to five groups each group comprising of five rats. The animals were grouped as: Group I-Normal control, Group II-Alloxan induced (150mg/kg b.wt), Group III-Alloxan + Poly Herbal Formulation (200mg/kg b.wt0, Group IV-Alloxan + Poly Herbal Formulation (400mg/kg b.wt) and Group V-glibenclamide (1mg/kg b.wt) for 30days. After the experimental period of 30 days, the blood and tissue samples were collected for preclinical trials. The parameter studied were fasting blood glucose, serum insulin, glucokinase, glucose-6-phosphatase, total protein, hepatic glycogen, serum cholesterol, triglycerides, serum urea and creatinine, lipid peroxide and superoxide dismutase. Results: Alloxan induced diabetic rats showed significant increase in fasting blood glucose, glucose-6-phosphatase, serum urea and creatinine, serum cholesterol and triglycerides and lipid peroxide and it also decrease in serum insulin, glucokinase, serum protein, hepatic glycogen and superoxide dismutase. Oral administration of Poly herbal formulation restored the levels of biochemical parameters and the level of glucose metabolizing enzymes. Conclusion: From the above findings, suggested that the poly herbal formulation possess antidiabetic activity and it can be used as starting point for the development of herbal based novel drug against diabetes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0e8f5a6b27f7c616cddf317d50fd6b48" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504658,"asset_id":121682103,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504658/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682103"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682103"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682103; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682102"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682102/Molecular_docking_ADME_analysis_and_pharmacophore_modelling_of_benzoxazole_fused_azetidinone_derivatives_as_antibreast_cancer_agents"><img alt="Research paper thumbnail of Molecular docking, ADME analysis, and pharmacophore modelling of benzoxazole fused azetidinone derivatives as antibreast cancer agents" class="work-thumbnail" src="https://attachments.academia-assets.com/116504652/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682102/Molecular_docking_ADME_analysis_and_pharmacophore_modelling_of_benzoxazole_fused_azetidinone_derivatives_as_antibreast_cancer_agents">Molecular docking, ADME analysis, and pharmacophore modelling of benzoxazole fused azetidinone derivatives as antibreast cancer agents</a></div><div class="wp-workCard_item"><span>Annals of Phytomedicine An International Journal</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Breast cancer is the most common cancer among women worldwide. In this study, different derivativ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Breast cancer is the most common cancer among women worldwide. In this study, different derivatives of benzoxazole-coupled azetidinone (DJ1-DJ20) were designed and investigated for antibreast cancer activity targeting a newly recognized receptor, PPARG (PDB:1FM9). These derivatives were designed with varying properties of substituent, such as hydrogen bonding ability, hydrophilicity, hydrophobicity, steric, and electronic effects. Firstly, designed compounds (DJ1-DJ20) were docked with receptor PPARG (PDB:1FM9), and the docking score was in the range of-5.180 to-8.485 kcal/mol. For further analysis, compounds having maximum interaction with receptors were selected based on the docking score greater than 7.5 kcal/mol. The selected compounds MM/GBSA, ADMET properties, pharmacophore modelling, and antibreast cancer properties were evaluated using computational tools, respectively. Among all the compounds, DJ10 showed the best interaction with receptors with the highest dock score of-8.485 kcal/mol and molecular mechanics with a generalized born and surface area solvation (MM/GBSA) score of-72.09 kcal/mol. Apart from these, all-selected compounds' physiochemical and druggable properties were within prescribed limits and adhered to Lipinski's rule of five and rule of three. Pharmacophore modelling showed the presence of steric and electronic features in the ligands to have supramolecular interaction with the PPARG receptor to produce a biological response. Finally, the selected compound's antibreast cancer properties were evaluated using PASS online tool to be antibreast cancer molecules with the highest possibility for compound DJ10 with a pharmacological active value of 0.293.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dac421a2531f73e33656d6324215829d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504652,"asset_id":121682102,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504652/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682102"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682102"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682102; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682102]").text(description); $(".js-view-count[data-work-id=121682102]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121682102; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121682102']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682101"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682101/In_Vivo_Phytotherapy_in_BALB_c_Athymic_Nude_Mice_Hair_Growth_Promotion_using_Ficus_religiosa_L_and_Morus_alba_L"><img alt="Research paper thumbnail of In Vivo Phytotherapy in BALB/c Athymic Nude Mice: Hair Growth Promotion using Ficus religiosa L. and Morus alba L" class="work-thumbnail" src="https://attachments.academia-assets.com/116504619/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682101/In_Vivo_Phytotherapy_in_BALB_c_Athymic_Nude_Mice_Hair_Growth_Promotion_using_Ficus_religiosa_L_and_Morus_alba_L">In Vivo Phytotherapy in BALB/c Athymic Nude Mice: Hair Growth Promotion using Ficus religiosa L. and Morus alba L</a></div><div class="wp-workCard_item"><span>Journal of Natural Remedies</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ficus religiosa L. (FR) and Morus alba L. (ML) belonging to the family Moraceae have been tested ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ficus religiosa L. (FR) and Morus alba L. (ML) belonging to the family Moraceae have been tested as novel herbal agents for hair growth promotion and Hair Follicles (HFs) regeneration in BALB/c athymic nude mouse model. Current study tested different mixtures of 5% aqueous fractions: Test 1 (ML2+ML3+ML4+FR4), Test 2 (FR1+FR2+FR4), or Test 3 (ML2+ML3+ML4+FR1+FR2+FR4) from leaves of both plants including standard of care 2% minoxidil. Control mice were untreated. Animals were treated for 33 days by topical application on the back skin and changes in hair growth patterns were evaluated. Histology was performed to assess the HFs morphology, and modulation of hair cycle phases. Gene expression analysis was performed to understand potential mechanisms of action. All treatment groups had significantly higher anagen phase HFs compared with untreated control group based on histology analysis. Also, expressions of CD34, CD200R and Oct4 genes were upregulated in all treatment groups compared w...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="95695ea38abed5df3ff46d960dacee39" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504619,"asset_id":121682101,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504619/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682101"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682101"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682101; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "95695ea38abed5df3ff46d960dacee39" } } $('.js-work-strip[data-work-id=121682101]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121682101,"title":"In Vivo Phytotherapy in BALB/c Athymic Nude Mice: Hair Growth Promotion using Ficus religiosa L. and Morus alba L","internal_url":"https://www.academia.edu/121682101/In_Vivo_Phytotherapy_in_BALB_c_Athymic_Nude_Mice_Hair_Growth_Promotion_using_Ficus_religiosa_L_and_Morus_alba_L","owner_id":199490985,"coauthors_can_edit":true,"owner":{"id":199490985,"first_name":"Dr Kishori","middle_initials":null,"last_name":"Apte","page_name":"DrKishoriApte","domain_name":"independent","created_at":"2021-07-27T02:27:43.567-07:00","display_name":"Dr Kishori Apte","url":"https://independent.academia.edu/DrKishoriApte"},"attachments":[{"id":116504619,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116504619/thumbnails/1.jpg","file_name":"20069.pdf","download_url":"https://www.academia.edu/attachments/116504619/download_file","bulk_download_file_name":"In_Vivo_Phytotherapy_in_BALB_c_Athymic_N.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116504619/20069-libre.pdf?1719836745=\u0026response-content-disposition=attachment%3B+filename%3DIn_Vivo_Phytotherapy_in_BALB_c_Athymic_N.pdf\u0026Expires=1740506627\u0026Signature=ZDZQ2jEqn1jY~hSeO3JzlnG-r8Jkwzbj6pO0JyWwyI7kxSxNnF1thPNgfnQzlMUsd454SGivx7iwwZLx61wRWRjTlVuCrPVUwFPZvW0bwQ3nqGfo~L7VAll1Zf4TSSVxyeCjUDsOKSeSP~JPalOL96IT1p0hOjBVsZUHpAlJLI-UaOR1DMqYN20pFx4P4syZB~pPQpkTobRMdtjj~Aw3MXDtOR86-7YSKhTW25udr~EYiwE7SOR8rYEvRLHcahJgyh2x5isTqz0klEq7fmvv-5eJGlkfxgN4dsW~soh~MvnDTugTwShPGXl4JzOgciOG5AR3E3bjtU08uwSO7JCPLg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682100"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/121682100/Anticancer_Activity_of_Casearia_Esculenta_in_Experimental_Models"><img alt="Research paper thumbnail of Anticancer Activity of Casearia Esculenta in Experimental Models" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/121682100/Anticancer_Activity_of_Casearia_Esculenta_in_Experimental_Models">Anticancer Activity of Casearia Esculenta in Experimental Models</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Increase in scientific investigations into indigenious wealth of herbal medicines gives ample evi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Increase in scientific investigations into indigenious wealth of herbal medicines gives ample evidence of medicinal plants as sources of drugs. Hepatocellular Carcinoma represents about 4% of all malignancies worldwide.Plants contain chemopreventive agents like phenolic compounds, nitrogen compounds and some other endogenous metabolites, which are rich in antioxidant activity. Thioacetamide, a model hepatotoxicant,initiates hepatocellular necrosis and further hepatocarcinogenesis. Thioacetamide thus produces oxidative stress on liver and causes hepatocellular carcinoma. This oxidative stress can be reversed by the use of antioxidants. Thus, the aim of this work was to evaluate the anticancer activity of hydroalcoholic extract prepared from Casearia esculenta, correlating the biochemical and histological changes in thioacetamide induced hepatocellular carcinoma in female Sprague Dawley rats. This research work should help shed some light on cancer research and experimental model deve...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682100"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682100"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682100; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682100]").text(description); 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The results showed that aqueous extract of Curcuma zedoaria and Gloriosa superba exhibited the prominent inhibitory effect whereas Curcuma longa and Curcuma caesia have moderate to weak effects in in vitro conditions as compared with standard drug 5-fluorouracil.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682099"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682099"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682099; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682099]").text(description); $(".js-view-count[data-work-id=121682099]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121682099; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121682099']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=121682099]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121682099,"title":"In-Vitro Screening of Some Medicinal Plants on Breast, Ovary and Colon Cancer Cell Lines","internal_url":"https://www.academia.edu/121682099/In_Vitro_Screening_of_Some_Medicinal_Plants_on_Breast_Ovary_and_Colon_Cancer_Cell_Lines","owner_id":199490985,"coauthors_can_edit":true,"owner":{"id":199490985,"first_name":"Dr Kishori","middle_initials":null,"last_name":"Apte","page_name":"DrKishoriApte","domain_name":"independent","created_at":"2021-07-27T02:27:43.567-07:00","display_name":"Dr Kishori Apte","url":"https://independent.academia.edu/DrKishoriApte"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682098"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682098/Synthesis_Biological_Activity_Molecular_Modelling_Studies_and_3D_QSARInvestigations_of_N_2_aryl_substituted_aryl_4_oxo_1_3_thiazolidin_3_yl_pyridine_4_carboxamides"><img alt="Research paper thumbnail of Synthesis, Biological Activity, Molecular Modelling Studies and 3D-QSARInvestigations of N-[2-(aryl/substituted aryl)-4-oxo-1, 3-thiazolidin-3-yl]pyridine-4-carboxamides" class="work-thumbnail" src="https://attachments.academia-assets.com/116504616/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682098/Synthesis_Biological_Activity_Molecular_Modelling_Studies_and_3D_QSARInvestigations_of_N_2_aryl_substituted_aryl_4_oxo_1_3_thiazolidin_3_yl_pyridine_4_carboxamides">Synthesis, Biological Activity, Molecular Modelling Studies and 3D-QSARInvestigations of N-[2-(aryl/substituted aryl)-4-oxo-1, 3-thiazolidin-3-yl]pyridine-4-carboxamides</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the present research work new 4-thiazolidinones possessing dual cyclooxygenase/lipoxygenase in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the present research work new 4-thiazolidinones possessing dual cyclooxygenase/lipoxygenase inhibition were synthesized. Sixteen N-(2-(aryl/substitutedaryl)-4-oxo-1,3-thiazolidin-3-yl)pyridine-4-carboxamide derivatives(5a-q) differing by the phenyl group substitution were synthesized by sonication. Compounds N-(2-(4-chlorophenyl)-4-oxo-1, 3- thiazolidin-3-yl) pyridine-4-carboxamide (5d) and N-(2-(4-nitrophenyl)-4-oxo-1, 3-thiazolidin-3-yl) pyridine-4-carbox- amide (5f) showed promising anti-inflammatory activity investigated by the carrageenan induced edema model in rats. Compound 5f, was the most active in the series with low ulcerogenic index and good safety profile with highest in vitro inhibition of COX-1/COX-2 (89.28; 52.80%, p&lt;0.01) with 27.36% inhibition of 15-LOX. Compounds 5d and 5f, at the dose of 100mg/kg p.o. were also effective in lowering the elevated levels of AST, ALT and ALP in serum and also lowered the elevated levels of MPO in edematous tissue comparable to...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c7f81d1ab70ff142a698a1a5cc5d350c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504616,"asset_id":121682098,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504616/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682098"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682098"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682098; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682097"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/121682097/The_study_of_antifertility_effect_of_seeds_of_Crotalaria_juncea_Linn"><img alt="Research paper thumbnail of The study of antifertility effect of seeds of Crotalaria juncea Linn" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/121682097/The_study_of_antifertility_effect_of_seeds_of_Crotalaria_juncea_Linn">The study of antifertility effect of seeds of Crotalaria juncea Linn</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682097"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682097"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682097; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682097]").text(description); $(".js-view-count[data-work-id=121682097]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121682097; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121682097']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=121682097]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121682097,"title":"The study of antifertility effect of seeds of Crotalaria juncea Linn","internal_url":"https://www.academia.edu/121682097/The_study_of_antifertility_effect_of_seeds_of_Crotalaria_juncea_Linn","owner_id":199490985,"coauthors_can_edit":true,"owner":{"id":199490985,"first_name":"Dr Kishori","middle_initials":null,"last_name":"Apte","page_name":"DrKishoriApte","domain_name":"independent","created_at":"2021-07-27T02:27:43.567-07:00","display_name":"Dr Kishori Apte","url":"https://independent.academia.edu/DrKishoriApte"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682095"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682095/A_study_to_evaluate_the_hepatoprotective_activity_of_prebiotics_probiotics_and_synbiotic_in_CCl4_induced_hepatotoxicity_in_rats"><img alt="Research paper thumbnail of A study to evaluate the hepatoprotective activity of prebiotics, probiotics, and synbiotic in CCl4 induced hepatotoxicity in rats" class="work-thumbnail" src="https://attachments.academia-assets.com/116504615/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682095/A_study_to_evaluate_the_hepatoprotective_activity_of_prebiotics_probiotics_and_synbiotic_in_CCl4_induced_hepatotoxicity_in_rats">A study to evaluate the hepatoprotective activity of prebiotics, probiotics, and synbiotic in CCl4 induced hepatotoxicity in rats</a></div><div class="wp-workCard_item"><span>Journal of Applied Pharmaceutical Science</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The current study was evaluated for the hepatoprotective activity of probiotics, prebiotics alone...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The current study was evaluated for the hepatoprotective activity of probiotics, prebiotics alone, and synbiotic of them. Animals were grouped into 12 groups (n = 6), i.e. normal control (NC), disease control (DC), treatment with prebiotics, probiotics alone, and synbiotic of them, and standard marketed hepatoprotective Silymarin along with Synbiotic 2000. All treatments were orally administered daily for 28 days. On the 28th day, all animals except the NC group received carbon tetrachloride (CCl 4) (1 ml/kg, i.p.). Levels of serum glutamic pyruvic transaminase (SGPT), serum glutamicoxaloacetic transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin, total protein, lactate dehydrogenase, and urea were evaluated. The tissues were evaluated for oxidative markers levels of catalase (CAT), lipid peroxidation (LPO), and glutathione (GSH), and total protein. Histopathology of tissues was carried out. Compositional analysis of intestinal microbiota was done by 16S amplicon sequencing. CCl 4 caused elevation in SGPT, SGOT, ALP, total bilirubin, urea, and lactate dehydrogenase in the DC group which was prevented with pretreatment of prebiotics, probiotics, and synbiotics. Total protein was decreased in serum and tissues after administration of CCl 4 which was restored with pretreatment of test substances. Oxidative marker LPO was increased in the DC group and catalase (CAT) and GSH were also depleted in liver tissue. These changes were prevented in pretreated test groups. The histological change in hepatic parenchyma and hepatocytes was minimal in test groups compared to DC. The 16S amplicon sequencing indicated that Lactobacillus acidophilus and prebiotic treatment effectively displaced Staphylococcus. Results suggested that the use of prebiotics, probiotics alone, and synbiotic of them has a protective effect against CCl 4-induced hepatotoxicity in rats.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a5d2f3969f282792a45eddce775311fb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504615,"asset_id":121682095,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504615/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682095"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682095"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682095; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682094"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/121682094/Evaluation_of_Antiosteoporotic_potential_of_Sesbania_grandiflora_Linn_aqueous_fraction_in_Ovariectomised_Rats"><img alt="Research paper thumbnail of Evaluation of Antiosteoporotic potential of Sesbania grandiflora Linn. aqueous fraction in Ovariectomised Rats" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/121682094/Evaluation_of_Antiosteoporotic_potential_of_Sesbania_grandiflora_Linn_aqueous_fraction_in_Ovariectomised_Rats">Evaluation of Antiosteoporotic potential of Sesbania grandiflora Linn. aqueous fraction in Ovariectomised Rats</a></div><div class="wp-workCard_item"><span>Research Journal of Pharmacy and Technology</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Sesbania grandiflora (SG), an Indian herbal drug has been traditionally employed to treat or prev...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Sesbania grandiflora (SG), an Indian herbal drug has been traditionally employed to treat or prevent female related hormonal disorders and mitigating symptoms of menopausal conditions. The present study assessed the antiosteoporotic potential of the aqueous extract of Sesbania grandiflora on bone metabolism in ovariectomised (OVX) rat model and its safety in the uterus. Thirty Sprague-Dawley 6 months old female rats were randomly divided into 5 groups: Sham operated group and four OVX subgroups (n=6), that were undergone bilateral ovariectomy. OVX rats were further subdivided into vehicle, raloxifene 5.4mg/kg/day, Sesbania grandiflora aqueous leaf extracts–250mg/kg/day and 500mg/kg/day respectively. The pharmacological effects of the extract were evaluated against osteoporosis by body weight, uterus wet weight, serum and urine biochemical parameters, bone mineral density, biomechanical strength, trabecular microarchitecture, histomorphology and uterus immunohistochemistry. Daily oral administration of aqueous leaf extract significantly assuages the symptoms of ovariectomy as shown by decreased levels of serum ALP, TRAP, hydroxyproline and urinary calcium in the treatment groups. Moreover, improved femur parameters were seen as increased bone strength, BMD, trabecular bone mass and microarchitecture similar to raloxifene. Histopathological data also showed significant restorative progression with increased ossification and mineralization of trabecular bone, without uterine hypertrophy. The results suggests that Sesbania grandiflora had a remarkable antiosteoporotic activity and may be a promising candidate for treatment of postmenopausal osteoporosis induced by estrogen deficiency in a natural way through herbal resources.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682094"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682094"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682094; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682094]").text(description); $(".js-view-count[data-work-id=121682094]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121682094; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121682094']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="121682093"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/121682093/Oral_intake_of_polyphenols_of_Chromolaena_odorata_A_perspective_in_peptic_ulcer_thrombocytopenia_and_heparin_induced_bleeding_diathesis_in_rodent_model"><img alt="Research paper thumbnail of Oral intake of polyphenols of Chromolaena odorata: A perspective in peptic ulcer, thrombocytopenia, and heparin-induced bleeding diathesis in rodent model" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/121682093/Oral_intake_of_polyphenols_of_Chromolaena_odorata_A_perspective_in_peptic_ulcer_thrombocytopenia_and_heparin_induced_bleeding_diathesis_in_rodent_model">Oral intake of polyphenols of Chromolaena odorata: A perspective in peptic ulcer, thrombocytopenia, and heparin-induced bleeding diathesis in rodent model</a></div><div class="wp-workCard_item"><span>Pharmacognosy Research</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective: Bleeding disorder is of two types: external bleeding due to trauma, surgery, and inter...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective: Bleeding disorder is of two types: external bleeding due to trauma, surgery, and internal bleeding which happens mainly due to ulcers and thrombocytopenia or use of excessive anticoagulants. Proven hemostatic activity of Chromolaena odorata (L) in bleeding and wound healing had encouraged to evaluate the efficacy of aqueous extract and spray-dried powder (SDP) on ulcers, thrombocytopenia, and heparin-induced bleeding diathesis. Materials and Methods: Internal bleeding in the form of lesions in empty stomach was induced by absolute ethanol. Busulfan is administered through intraperitoneal injection to produce thrombocytopenia in Wistar rats and heparin at 1000 IU/ml was injected intravenous to mice, and after 30 min, tail was truncated to qualitatively and quantitatively differentiate the bleeding diathesis in treated versus nontreated controls. Results: A significant reduction in the lesions was observed in treated rats as compared to disease control rats which was evident from ulcer index and histopathology data. Considerable protection and production of platelets were observed in the thrombocytopenia model which was drastically reduced in the Busulfan administered disease control. Both aqueous extract and SDP were successful in preventing blood loss in heparin-induced tail-bleeding model. Conclusion: The presence of polyphenols attributes to the crucial role of C. odorata in arresting internal bleeding from stomach ulcer, protecting the thrombocytes from destroying, and minimizing the bleeding diathesis in mice. Abbreviations Used: SDP: Spray-dried powder, μL: Microliter, ml: Milliliter, nm: Nanometer, μg: Microgram, NAD: No abnormality detected, SD: Standard deviation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682093"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682093"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682093; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682093]").text(description); $(".js-view-count[data-work-id=121682093]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121682093; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121682093']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=121682093]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121682093,"title":"Oral intake of polyphenols of Chromolaena odorata: A perspective in peptic ulcer, thrombocytopenia, and heparin-induced bleeding diathesis in rodent model","internal_url":"https://www.academia.edu/121682093/Oral_intake_of_polyphenols_of_Chromolaena_odorata_A_perspective_in_peptic_ulcer_thrombocytopenia_and_heparin_induced_bleeding_diathesis_in_rodent_model","owner_id":199490985,"coauthors_can_edit":true,"owner":{"id":199490985,"first_name":"Dr Kishori","middle_initials":null,"last_name":"Apte","page_name":"DrKishoriApte","domain_name":"independent","created_at":"2021-07-27T02:27:43.567-07:00","display_name":"Dr Kishori Apte","url":"https://independent.academia.edu/DrKishoriApte"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682092"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682092/Role_of_Adiantum_philippense_L_on_glucose_uptake_in_isolated_pancreatic_cells_and_inhibition_of_adipocyte_differentiation_in_3T3_L1_cell_line"><img alt="Research paper thumbnail of Role of Adiantum philippense L. on glucose uptake in isolated pancreatic cells and inhibition of adipocyte differentiation in 3T3-L1 cell line" class="work-thumbnail" src="https://attachments.academia-assets.com/116504651/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682092/Role_of_Adiantum_philippense_L_on_glucose_uptake_in_isolated_pancreatic_cells_and_inhibition_of_adipocyte_differentiation_in_3T3_L1_cell_line">Role of Adiantum philippense L. on glucose uptake in isolated pancreatic cells and inhibition of adipocyte differentiation in 3T3-L1 cell line</a></div><div class="wp-workCard_item"><span>Pharmacognosy Magazine</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Adiantum philippense (AP) is a pteridophyte that shows antihyperglycemic activity in ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Adiantum philippense (AP) is a pteridophyte that shows antihyperglycemic activity in vivo diabetic model, but the mechanism of action is unknown. Objective: AP was found to play a pivotal role in minimizing the high blood glucose in alloxan-induced diabetic rats. Simultaneously, it was observed that it could maintain the normal lipid profile even in diabetic condition. To investigate its insulin-like activity along with its inhibitory role on adipocyte differentiation became the objective of our present study. Materials and Methods: Glucose uptake potential of this fern was done in isolated pancreatic islets and inhibition of adipocyte differentiation was assessed in 3T3-L1 cell line. Before this, the cytotoxic concentration was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on L929 cell line. To determine its role in lipid metabolism, the oil droplets produced in adipocytes were stained with Oil 'O' red staining, and triglyceride levels of various drug treatments were measured spectrophotometrically. Results: This fern extract was found to be actively utilizing glucose in the glucose uptake assay. Moreover, it was also involved in inhibiting differentiation of pro-adipocyte to adipocyte in the 3T3-L1 cell lines. The percentage inhibition as obtained from the absorbance showed that the ethanolic extract at the concentration of 200 µg/ml showed 32.48% inhibition. Conclusion: All the above-mentioned parameters when appraised indicated that this fern could be used as an alternative medicine in managing diabetes associated with obesity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0833c6f6bd43c220dba0da23bb5641be" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504651,"asset_id":121682092,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504651/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682092"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682092"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682092; 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</script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="19780845" id="papers"><div class="js-work-strip profile--work_container" data-work-id="121682112"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682112/_i_Cassia_auriculata_i_Aspects_of_Safety_Pharmacology_and_Drug_Interaction"><img alt="Research paper thumbnail of <i>Cassia auriculata</i>: Aspects of Safety Pharmacology and Drug Interaction" class="work-thumbnail" src="https://attachments.academia-assets.com/116504656/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682112/_i_Cassia_auriculata_i_Aspects_of_Safety_Pharmacology_and_Drug_Interaction"><i>Cassia auriculata</i>: Aspects of Safety Pharmacology and Drug Interaction</a></div><div class="wp-workCard_item"><span>Evidence-based Complementary and Alternative Medicine</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried ou...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-based supercritical extract of Cassia auriculata for 12 weeks. Our studies indicate that both these extracts are pharmacologically safe and did not show any significant adverse reactions at the tested doses. The traditional hydro-alcoholic extract did not show any significant effect on pharmacokinetics; however, the technology-based supercritical extract caused a significant reduction in absorption of metformin. Our results indicate the need to include pharmacokinetic herbdrug interaction studies as evidence for safety especially for technology-based extracts.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3c471c85718923e216f20ef567f29980" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504656,"asset_id":121682112,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504656/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682112"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682112"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682112; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682112]").text(description); $(".js-view-count[data-work-id=121682112]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121682112; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121682112']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682111"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682111/Synthesis_Biological_Activity_Molecular_Modelling_Studies_and_3D_QSARInvestigations_of_N_2_aryl_substituted_aryl_4_oxo_1_3_thiazolidin_3_yl_pyridine_4_carboxamides"><img alt="Research paper thumbnail of Synthesis, Biological Activity, Molecular Modelling Studies and 3D-QSARInvestigations of N-[2-(aryl/substituted aryl)-4-oxo-1, 3-thiazolidin-3-yl]pyridine-4-carboxamides" class="work-thumbnail" src="https://attachments.academia-assets.com/116504655/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682111/Synthesis_Biological_Activity_Molecular_Modelling_Studies_and_3D_QSARInvestigations_of_N_2_aryl_substituted_aryl_4_oxo_1_3_thiazolidin_3_yl_pyridine_4_carboxamides">Synthesis, Biological Activity, Molecular Modelling Studies and 3D-QSARInvestigations of N-[2-(aryl/substituted aryl)-4-oxo-1, 3-thiazolidin-3-yl]pyridine-4-carboxamides</a></div><div class="wp-workCard_item"><span>The open conference proceedings journal</span><span>, Dec 13, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the present research work new 4-thiazolidinones possessing dual cyclooxygenase/lipoxygenase in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the present research work new 4-thiazolidinones possessing dual cyclooxygenase/lipoxygenase inhibition were synthesized. Sixteen N-[2-(aryl/substitutedaryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide derivatives(5a-q) differing by the phenyl group substitution were synthesized by sonication. Compounds N-[2-(4-chlorophenyl)-4-oxo-1, 3thiazolidin-3-yl] pyridine-4-carboxamide (5d) and N-[2-(4-nitrophenyl)-4-oxo-1, 3-thiazolidin-3-yl] pyridine-4-carboxamide (5f) showed promising anti-inflammatory activity investigated by the carrageenan induced edema model in rats. Compound 5f, was the most active in the series with low ulcerogenic index and good safety profile with highest in vitro inhibition of COX-1/COX-2 (89.28; 52.80%, p<0.01) with 27.36% inhibition of 15-LOX. Compounds 5d and 5f, at the dose of 100mg/kg p.o. were also effective in lowering the elevated levels of AST, ALT and ALP in serum and also lowered the elevated levels of MPO in edematous tissue comparable to standard anti-inflammatory drug, Indomethacin. The Autodock investigation of the synthesized compounds within the COX and LOX enzymes predicted fairly good correlation between the anti-inflammatory activities (IC 50) and their binding affinities. The 3D-QSAR studies (V-Life Molecular Design Software) of the synthesized 4-thiazolidinones for their anti-inflammatory activity by the developed kNN, PLRS and MLR models suggested that presence of electron withdrawing functional groups like-NO 2,-Cl on the phenyl ring were favourable for activity. The results of the present study may help to identify the relative positions and ranges of important electrostatic and steric fields at various positions around the pharmacophore that could be useful in the design of new molecules with improved anti-inflammatory activity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b2a75ba61809fbee969072fcd0124a5e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504655,"asset_id":121682111,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504655/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682111"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682111"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682111; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682110"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682110/Medicinal_Plants_as_Potential_Source_of_Anticancer_Agents_A_Review"><img alt="Research paper thumbnail of Medicinal Plants as Potential Source of Anticancer Agents: A Review" class="work-thumbnail" src="https://attachments.academia-assets.com/116504625/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682110/Medicinal_Plants_as_Potential_Source_of_Anticancer_Agents_A_Review">Medicinal Plants as Potential Source of Anticancer Agents: A Review</a></div><div class="wp-workCard_item"><span>Journal of Pharmacognosy and Phytochemistry</span><span>, Mar 1, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cancer is a major public health burden in both developed and developing countries. Anticancer act...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cancer is a major public health burden in both developed and developing countries. Anticancer activity is the effect of natural and synthetic or biological and chemical agents to reverse, suppress or prevent carcinogenic progression. Several synthetic agents are used to cure the disease but they have their toxicity and hence the research is going on to investigate the plant derived chemotherapeutic agents. Therefore an attempt has been made to review some medicinal plants having anticancer properties. In this review, anticancer medicinal plants of Indian origin belonging to various families are reported along with detailed information. All these plants are potential candidates for advanced studies since they are showing good anticancer activity. The present paper is a comprehensive review of different literature sources. It will be helpful to explore the medicinal value of the plants against the cancer and for the new drug discovery from them for the researchers and scientists around the world.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e23eea209ce3db4d330b96743bd01077" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504625,"asset_id":121682110,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504625/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682110"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682110"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682110; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682108"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/121682108/The_study_of_antifertility_effect_of_seeds_of_Crotalaria_juncea_Linn"><img alt="Research paper thumbnail of The study of antifertility effect of seeds of Crotalaria juncea Linn" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/121682108/The_study_of_antifertility_effect_of_seeds_of_Crotalaria_juncea_Linn">The study of antifertility effect of seeds of Crotalaria juncea Linn</a></div><div class="wp-workCard_item"><span>Shodhganga</span><span>, 1991</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682108"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682108"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682108; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682108]").text(description); $(".js-view-count[data-work-id=121682108]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121682108; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121682108']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=121682108]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121682108,"title":"The study of antifertility effect of seeds of Crotalaria juncea Linn","internal_url":"https://www.academia.edu/121682108/The_study_of_antifertility_effect_of_seeds_of_Crotalaria_juncea_Linn","owner_id":199490985,"coauthors_can_edit":true,"owner":{"id":199490985,"first_name":"Dr Kishori","middle_initials":null,"last_name":"Apte","page_name":"DrKishoriApte","domain_name":"independent","created_at":"2021-07-27T02:27:43.567-07:00","display_name":"Dr Kishori Apte","url":"https://independent.academia.edu/DrKishoriApte"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682107"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/121682107/In_Vitro_Screening_of_Some_Medicinal_Plants_on_Breast_Ovary_and_Colon_Cancer_Cell_Lines"><img alt="Research paper thumbnail of In-Vitro Screening of Some Medicinal Plants on Breast, Ovary and Colon Cancer Cell Lines" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/121682107/In_Vitro_Screening_of_Some_Medicinal_Plants_on_Breast_Ovary_and_Colon_Cancer_Cell_Lines">In-Vitro Screening of Some Medicinal Plants on Breast, Ovary and Colon Cancer Cell Lines</a></div><div class="wp-workCard_item"><span>International journal of pharma and bio sciences</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the present study, the aqueous extracts of Curcum caesia, Curcuma longa, Curcuma zedoaria and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the present study, the aqueous extracts of Curcum caesia, Curcuma longa, Curcuma zedoaria and Gloriosa superba was studied for their in vitro cytotoxic activity against human breast cancer (MCF-7), colon cancer (HCT-116) and ovarian cancer (PA-1) cell lines using sulphorhodamine B (SRB) assay. The results showed that aqueous extract of Curcuma zedoaria and Gloriosa superba exhibited the prominent inhibitory effect whereas Curcuma longa and Curcuma caesia have moderate to weak effects in in vitro conditions as compared with standard drug 5-fluorouracil.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682107"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682107"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682107; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682107]").text(description); $(".js-view-count[data-work-id=121682107]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121682107; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121682107']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=121682107]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121682107,"title":"In-Vitro Screening of Some Medicinal Plants on Breast, Ovary and Colon Cancer Cell Lines","internal_url":"https://www.academia.edu/121682107/In_Vitro_Screening_of_Some_Medicinal_Plants_on_Breast_Ovary_and_Colon_Cancer_Cell_Lines","owner_id":199490985,"coauthors_can_edit":true,"owner":{"id":199490985,"first_name":"Dr Kishori","middle_initials":null,"last_name":"Apte","page_name":"DrKishoriApte","domain_name":"independent","created_at":"2021-07-27T02:27:43.567-07:00","display_name":"Dr Kishori Apte","url":"https://independent.academia.edu/DrKishoriApte"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682106"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682106/Role_of_Adiantum_philippense_L_on_glucose_uptake_in_isolated_pancreatic_cells_and_inhibition_of_adipocyte_differentiation_in_3T3_L1_cell_line"><img alt="Research paper thumbnail of Role of Adiantum philippense L. on glucose uptake in isolated pancreatic cells and inhibition of adipocyte differentiation in 3T3-L1 cell line" class="work-thumbnail" src="https://attachments.academia-assets.com/116504654/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682106/Role_of_Adiantum_philippense_L_on_glucose_uptake_in_isolated_pancreatic_cells_and_inhibition_of_adipocyte_differentiation_in_3T3_L1_cell_line">Role of Adiantum philippense L. on glucose uptake in isolated pancreatic cells and inhibition of adipocyte differentiation in 3T3-L1 cell line</a></div><div class="wp-workCard_item"><span>Pharmacognosy Magazine</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Adiantum philippense (AP) is a pteridophyte that shows antihyperglycemic activity in ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Adiantum philippense (AP) is a pteridophyte that shows antihyperglycemic activity in vivo diabetic model, but the mechanism of action is unknown. Objective: AP was found to play a pivotal role in minimizing the high blood glucose in alloxan-induced diabetic rats. Simultaneously, it was observed that it could maintain the normal lipid profile even in diabetic condition. To investigate its insulin-like activity along with its inhibitory role on adipocyte differentiation became the objective of our present study. Materials and Methods: Glucose uptake potential of this fern was done in isolated pancreatic islets and inhibition of adipocyte differentiation was assessed in 3T3-L1 cell line. Before this, the cytotoxic concentration was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on L929 cell line. To determine its role in lipid metabolism, the oil droplets produced in adipocytes were stained with Oil 'O' red staining, and triglyceride levels of various drug treatments were measured spectrophotometrically. Results: This fern extract was found to be actively utilizing glucose in the glucose uptake assay. Moreover, it was also involved in inhibiting differentiation of pro-adipocyte to adipocyte in the 3T3-L1 cell lines. The percentage inhibition as obtained from the absorbance showed that the ethanolic extract at the concentration of 200 µg/ml showed 32.48% inhibition. Conclusion: All the above-mentioned parameters when appraised indicated that this fern could be used as an alternative medicine in managing diabetes associated with obesity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1e22d4349f46d14931a08dde2b474f88" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504654,"asset_id":121682106,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504654/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682106"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682106"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682106; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1e22d4349f46d14931a08dde2b474f88" } } $('.js-work-strip[data-work-id=121682106]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121682106,"title":"Role of Adiantum philippense L. on glucose uptake in isolated pancreatic cells and inhibition of adipocyte differentiation in 3T3-L1 cell line","internal_url":"https://www.academia.edu/121682106/Role_of_Adiantum_philippense_L_on_glucose_uptake_in_isolated_pancreatic_cells_and_inhibition_of_adipocyte_differentiation_in_3T3_L1_cell_line","owner_id":199490985,"coauthors_can_edit":true,"owner":{"id":199490985,"first_name":"Dr Kishori","middle_initials":null,"last_name":"Apte","page_name":"DrKishoriApte","domain_name":"independent","created_at":"2021-07-27T02:27:43.567-07:00","display_name":"Dr Kishori Apte","url":"https://independent.academia.edu/DrKishoriApte"},"attachments":[{"id":116504654,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116504654/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/116504654/download_file","bulk_download_file_name":"Role_of_Adiantum_philippense_L_on_glucos.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116504654/pdf.pdf?1719836517=\u0026response-content-disposition=attachment%3B+filename%3DRole_of_Adiantum_philippense_L_on_glucos.pdf\u0026Expires=1740506627\u0026Signature=cUMifOZMt3lUiCYqDD0RT60sOFmPcgqg4uyhqYFERoB1zGl7qtC8o~vJ-WRN8Ed0ZcrVNoJHBdIFiuTov6GfiWZChtkp35PhsTR02I3~vMHDfAX7mmGCDyv8neqkmeZWOs9iIIOR3q0v1Psa74cvcjVIuEgEB2YyGoSotQqV780331aZMfRSnALtf0HL1Sac5gMqpMmQSODT0yPme3KCZR8dvZO61mB6EnAW92d~oYvKRDpUqjTKkPjpfDGjuIEDmXfG6izYzLOhJThsOl9ZJSVlwzI78iXP4ElyAwpYrkeUQm3TL3gXo5rfS3EzHWZs0tvTkvtTV-qX~R~gDxaQTw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682105"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682105/Comparative_Anticancer_Evaluation_of_Curcuma_zedoaria_and_Gloriosa_superba_against_7_12_Dimethylbenz_a_anthracene_DMBA_Induced_Mammary_Tumors_in_Rats"><img alt="Research paper thumbnail of Comparative Anticancer Evaluation of Curcuma zedoaria and Gloriosa superba against 7, 12-Dimethylbenz [a] anthracene (DMBA) Induced Mammary Tumors in Rats" class="work-thumbnail" src="https://attachments.academia-assets.com/116504620/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682105/Comparative_Anticancer_Evaluation_of_Curcuma_zedoaria_and_Gloriosa_superba_against_7_12_Dimethylbenz_a_anthracene_DMBA_Induced_Mammary_Tumors_in_Rats">Comparative Anticancer Evaluation of Curcuma zedoaria and Gloriosa superba against 7, 12-Dimethylbenz [a] anthracene (DMBA) Induced Mammary Tumors in Rats</a></div><div class="wp-workCard_item"><span>Journal of current pharma research</span><span>, Nov 15, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this study tumors were developed with carcinogenic agent 7-12 Dimethylbenz[a] anthracene (DMBA...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this study tumors were developed with carcinogenic agent 7-12 Dimethylbenz[a] anthracene (DMBA) in female albino wistar rats at a dose of 7.5 mg/kg sc. once in a week for 4 weeks and waited for 90 days considering from first day of initiation until development of tumors. Once tumors were developed at 90 days then tumor size was measured weekly with digital vernier caliper for four weeks during the treatment of plant extracts. Plant extracts of Curcuma zedoaria and Gloriosa superba comparatively evaluated for their potential to reduce tumor size against Paclitaxel. Administration of aqueous extracts of Curcuma zedoaria and Gloriosa superba at dose of 5mg/kg body weight orally for 30 days was associated with significant decrease in tumor volume as compare to that of Paclitaxel which was given at dose of 1mg/kg body weight i.p. Apart from this Curcuma zedoaria and Gloriosa superba aqueous plants extracts treated groups has shown significant down regulation of biological markers like SGPT, ALP, LDH, LPO, Urea, and up regulation of GSH, Total protein. Therefore Curcuma zedoaria and Gloriosa superba when administered orally can act as effective curative agent towards DMBA induced mammary tumors.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e38993a7144abecdfd1a9718801198c4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504620,"asset_id":121682105,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504620/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682105"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682105"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682105; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682103"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682103/Anti_Diabetic_potential_of_a_polyherbal_formulation_A_review"><img alt="Research paper thumbnail of Anti-Diabetic potential of a polyherbal formulation-A review" class="work-thumbnail" src="https://attachments.academia-assets.com/116504658/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682103/Anti_Diabetic_potential_of_a_polyherbal_formulation_A_review">Anti-Diabetic potential of a polyherbal formulation-A review</a></div><div class="wp-workCard_item"><span>Research Journal of Pharmacy and Technology</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aim: The present study was aimed to design the effect of poly herbal formulation against alloxan ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aim: The present study was aimed to design the effect of poly herbal formulation against alloxan induced diabetic rats. The formulation was prepared by using three common herbal plants namely Alternanthera sessilis Linn., Amaranthus viridis Linn., and Boerhavia diffusa Linn., and glibenclamide as a standard. Methods: The rats were divided in to five groups each group comprising of five rats. The animals were grouped as: Group I-Normal control, Group II-Alloxan induced (150mg/kg b.wt), Group III-Alloxan + Poly Herbal Formulation (200mg/kg b.wt0, Group IV-Alloxan + Poly Herbal Formulation (400mg/kg b.wt) and Group V-glibenclamide (1mg/kg b.wt) for 30days. After the experimental period of 30 days, the blood and tissue samples were collected for preclinical trials. The parameter studied were fasting blood glucose, serum insulin, glucokinase, glucose-6-phosphatase, total protein, hepatic glycogen, serum cholesterol, triglycerides, serum urea and creatinine, lipid peroxide and superoxide dismutase. Results: Alloxan induced diabetic rats showed significant increase in fasting blood glucose, glucose-6-phosphatase, serum urea and creatinine, serum cholesterol and triglycerides and lipid peroxide and it also decrease in serum insulin, glucokinase, serum protein, hepatic glycogen and superoxide dismutase. Oral administration of Poly herbal formulation restored the levels of biochemical parameters and the level of glucose metabolizing enzymes. Conclusion: From the above findings, suggested that the poly herbal formulation possess antidiabetic activity and it can be used as starting point for the development of herbal based novel drug against diabetes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0e8f5a6b27f7c616cddf317d50fd6b48" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504658,"asset_id":121682103,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504658/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682103"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682103"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682103; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682103]").text(description); $(".js-view-count[data-work-id=121682103]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121682103; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121682103']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "0e8f5a6b27f7c616cddf317d50fd6b48" } } $('.js-work-strip[data-work-id=121682103]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121682103,"title":"Anti-Diabetic potential of a polyherbal formulation-A review","internal_url":"https://www.academia.edu/121682103/Anti_Diabetic_potential_of_a_polyherbal_formulation_A_review","owner_id":199490985,"coauthors_can_edit":true,"owner":{"id":199490985,"first_name":"Dr Kishori","middle_initials":null,"last_name":"Apte","page_name":"DrKishoriApte","domain_name":"independent","created_at":"2021-07-27T02:27:43.567-07:00","display_name":"Dr Kishori Apte","url":"https://independent.academia.edu/DrKishoriApte"},"attachments":[{"id":116504658,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116504658/thumbnails/1.jpg","file_name":"2230-8407.09817120240701-1-7c839a.pdf","download_url":"https://www.academia.edu/attachments/116504658/download_file","bulk_download_file_name":"Anti_Diabetic_potential_of_a_polyherbal.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116504658/2230-8407.09817120240701-1-7c839a-libre.pdf?1719836731=\u0026response-content-disposition=attachment%3B+filename%3DAnti_Diabetic_potential_of_a_polyherbal.pdf\u0026Expires=1740506627\u0026Signature=Fq4p82rrGa~VwDkRkvvSdc2CNBw4eAXrsfSdREFxwq63I4lOp1FcIRTOiif0b6tVyrmByejJuP8nfn9xFE~9WRGz74ETNMWEYJh8pc36ROTQW5oOQcKqyU3mAIONtQkh~BQu3YUJJ7rXVRs8nYqR2C4IPWZNbpRy8-3rS1zR4GSMz-wp~q8VLWmtvss9kDSp54bguhcWEWcNtcz6cIiym4QncGdtszzMHZrz8Kh8jDK68i7HIh7htTkDb7ucTYpvIOTcXKx5M3Osa9EYNG0Lab6V9XLgPQxq0WAf3NstTCx~FzfBdb~8JyUJkaAYSMY7lRf1sMtRKxstybszoQGAUA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682102"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682102/Molecular_docking_ADME_analysis_and_pharmacophore_modelling_of_benzoxazole_fused_azetidinone_derivatives_as_antibreast_cancer_agents"><img alt="Research paper thumbnail of Molecular docking, ADME analysis, and pharmacophore modelling of benzoxazole fused azetidinone derivatives as antibreast cancer agents" class="work-thumbnail" src="https://attachments.academia-assets.com/116504652/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682102/Molecular_docking_ADME_analysis_and_pharmacophore_modelling_of_benzoxazole_fused_azetidinone_derivatives_as_antibreast_cancer_agents">Molecular docking, ADME analysis, and pharmacophore modelling of benzoxazole fused azetidinone derivatives as antibreast cancer agents</a></div><div class="wp-workCard_item"><span>Annals of Phytomedicine An International Journal</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Breast cancer is the most common cancer among women worldwide. In this study, different derivativ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Breast cancer is the most common cancer among women worldwide. In this study, different derivatives of benzoxazole-coupled azetidinone (DJ1-DJ20) were designed and investigated for antibreast cancer activity targeting a newly recognized receptor, PPARG (PDB:1FM9). These derivatives were designed with varying properties of substituent, such as hydrogen bonding ability, hydrophilicity, hydrophobicity, steric, and electronic effects. Firstly, designed compounds (DJ1-DJ20) were docked with receptor PPARG (PDB:1FM9), and the docking score was in the range of-5.180 to-8.485 kcal/mol. For further analysis, compounds having maximum interaction with receptors were selected based on the docking score greater than 7.5 kcal/mol. The selected compounds MM/GBSA, ADMET properties, pharmacophore modelling, and antibreast cancer properties were evaluated using computational tools, respectively. Among all the compounds, DJ10 showed the best interaction with receptors with the highest dock score of-8.485 kcal/mol and molecular mechanics with a generalized born and surface area solvation (MM/GBSA) score of-72.09 kcal/mol. Apart from these, all-selected compounds' physiochemical and druggable properties were within prescribed limits and adhered to Lipinski's rule of five and rule of three. Pharmacophore modelling showed the presence of steric and electronic features in the ligands to have supramolecular interaction with the PPARG receptor to produce a biological response. Finally, the selected compound's antibreast cancer properties were evaluated using PASS online tool to be antibreast cancer molecules with the highest possibility for compound DJ10 with a pharmacological active value of 0.293.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dac421a2531f73e33656d6324215829d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504652,"asset_id":121682102,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504652/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682102"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682102"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682102; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682101"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682101/In_Vivo_Phytotherapy_in_BALB_c_Athymic_Nude_Mice_Hair_Growth_Promotion_using_Ficus_religiosa_L_and_Morus_alba_L"><img alt="Research paper thumbnail of In Vivo Phytotherapy in BALB/c Athymic Nude Mice: Hair Growth Promotion using Ficus religiosa L. and Morus alba L" class="work-thumbnail" src="https://attachments.academia-assets.com/116504619/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682101/In_Vivo_Phytotherapy_in_BALB_c_Athymic_Nude_Mice_Hair_Growth_Promotion_using_Ficus_religiosa_L_and_Morus_alba_L">In Vivo Phytotherapy in BALB/c Athymic Nude Mice: Hair Growth Promotion using Ficus religiosa L. and Morus alba L</a></div><div class="wp-workCard_item"><span>Journal of Natural Remedies</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ficus religiosa L. (FR) and Morus alba L. (ML) belonging to the family Moraceae have been tested ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ficus religiosa L. (FR) and Morus alba L. (ML) belonging to the family Moraceae have been tested as novel herbal agents for hair growth promotion and Hair Follicles (HFs) regeneration in BALB/c athymic nude mouse model. Current study tested different mixtures of 5% aqueous fractions: Test 1 (ML2+ML3+ML4+FR4), Test 2 (FR1+FR2+FR4), or Test 3 (ML2+ML3+ML4+FR1+FR2+FR4) from leaves of both plants including standard of care 2% minoxidil. Control mice were untreated. Animals were treated for 33 days by topical application on the back skin and changes in hair growth patterns were evaluated. Histology was performed to assess the HFs morphology, and modulation of hair cycle phases. Gene expression analysis was performed to understand potential mechanisms of action. All treatment groups had significantly higher anagen phase HFs compared with untreated control group based on histology analysis. Also, expressions of CD34, CD200R and Oct4 genes were upregulated in all treatment groups compared w...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="95695ea38abed5df3ff46d960dacee39" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504619,"asset_id":121682101,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504619/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682101"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682101"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682101; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682100"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/121682100/Anticancer_Activity_of_Casearia_Esculenta_in_Experimental_Models"><img alt="Research paper thumbnail of Anticancer Activity of Casearia Esculenta in Experimental Models" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/121682100/Anticancer_Activity_of_Casearia_Esculenta_in_Experimental_Models">Anticancer Activity of Casearia Esculenta in Experimental Models</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Increase in scientific investigations into indigenious wealth of herbal medicines gives ample evi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Increase in scientific investigations into indigenious wealth of herbal medicines gives ample evidence of medicinal plants as sources of drugs. Hepatocellular Carcinoma represents about 4% of all malignancies worldwide.Plants contain chemopreventive agents like phenolic compounds, nitrogen compounds and some other endogenous metabolites, which are rich in antioxidant activity. Thioacetamide, a model hepatotoxicant,initiates hepatocellular necrosis and further hepatocarcinogenesis. Thioacetamide thus produces oxidative stress on liver and causes hepatocellular carcinoma. This oxidative stress can be reversed by the use of antioxidants. Thus, the aim of this work was to evaluate the anticancer activity of hydroalcoholic extract prepared from Casearia esculenta, correlating the biochemical and histological changes in thioacetamide induced hepatocellular carcinoma in female Sprague Dawley rats. This research work should help shed some light on cancer research and experimental model deve...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682100"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682100"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682100; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682100]").text(description); 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=121682100]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121682100,"title":"Anticancer Activity of Casearia Esculenta in Experimental Models","internal_url":"https://www.academia.edu/121682100/Anticancer_Activity_of_Casearia_Esculenta_in_Experimental_Models","owner_id":199490985,"coauthors_can_edit":true,"owner":{"id":199490985,"first_name":"Dr Kishori","middle_initials":null,"last_name":"Apte","page_name":"DrKishoriApte","domain_name":"independent","created_at":"2021-07-27T02:27:43.567-07:00","display_name":"Dr Kishori Apte","url":"https://independent.academia.edu/DrKishoriApte"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682099"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/121682099/In_Vitro_Screening_of_Some_Medicinal_Plants_on_Breast_Ovary_and_Colon_Cancer_Cell_Lines"><img alt="Research paper thumbnail of In-Vitro Screening of Some Medicinal Plants on Breast, Ovary and Colon Cancer Cell Lines" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/121682099/In_Vitro_Screening_of_Some_Medicinal_Plants_on_Breast_Ovary_and_Colon_Cancer_Cell_Lines">In-Vitro Screening of Some Medicinal Plants on Breast, Ovary and Colon Cancer Cell Lines</a></div><div class="wp-workCard_item"><span>International journal of pharma and bio sciences</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the present study, the aqueous extracts of Curcum caesia, Curcuma longa, Curcuma zedoaria and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the present study, the aqueous extracts of Curcum caesia, Curcuma longa, Curcuma zedoaria and Gloriosa superba was studied for their in vitro cytotoxic activity against human breast cancer (MCF-7), colon cancer (HCT-116) and ovarian cancer (PA-1) cell lines using sulphorhodamine B (SRB) assay. The results showed that aqueous extract of Curcuma zedoaria and Gloriosa superba exhibited the prominent inhibitory effect whereas Curcuma longa and Curcuma caesia have moderate to weak effects in in vitro conditions as compared with standard drug 5-fluorouracil.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682099"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682099"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682099; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682099]").text(description); $(".js-view-count[data-work-id=121682099]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121682099; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121682099']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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Sixteen N-(2-(aryl/substitutedaryl)-4-oxo-1,3-thiazolidin-3-yl)pyridine-4-carboxamide derivatives(5a-q) differing by the phenyl group substitution were synthesized by sonication. Compounds N-(2-(4-chlorophenyl)-4-oxo-1, 3- thiazolidin-3-yl) pyridine-4-carboxamide (5d) and N-(2-(4-nitrophenyl)-4-oxo-1, 3-thiazolidin-3-yl) pyridine-4-carbox- amide (5f) showed promising anti-inflammatory activity investigated by the carrageenan induced edema model in rats. Compound 5f, was the most active in the series with low ulcerogenic index and good safety profile with highest in vitro inhibition of COX-1/COX-2 (89.28; 52.80%, p&lt;0.01) with 27.36% inhibition of 15-LOX. Compounds 5d and 5f, at the dose of 100mg/kg p.o. were also effective in lowering the elevated levels of AST, ALT and ALP in serum and also lowered the elevated levels of MPO in edematous tissue comparable to...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c7f81d1ab70ff142a698a1a5cc5d350c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504616,"asset_id":121682098,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504616/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682098"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682098"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682098; 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window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682097]").text(description); $(".js-view-count[data-work-id=121682097]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121682097; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121682097']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=121682097]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121682097,"title":"The study of antifertility effect of seeds of Crotalaria juncea Linn","internal_url":"https://www.academia.edu/121682097/The_study_of_antifertility_effect_of_seeds_of_Crotalaria_juncea_Linn","owner_id":199490985,"coauthors_can_edit":true,"owner":{"id":199490985,"first_name":"Dr Kishori","middle_initials":null,"last_name":"Apte","page_name":"DrKishoriApte","domain_name":"independent","created_at":"2021-07-27T02:27:43.567-07:00","display_name":"Dr Kishori Apte","url":"https://independent.academia.edu/DrKishoriApte"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682095"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682095/A_study_to_evaluate_the_hepatoprotective_activity_of_prebiotics_probiotics_and_synbiotic_in_CCl4_induced_hepatotoxicity_in_rats"><img alt="Research paper thumbnail of A study to evaluate the hepatoprotective activity of prebiotics, probiotics, and synbiotic in CCl4 induced hepatotoxicity in rats" class="work-thumbnail" src="https://attachments.academia-assets.com/116504615/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682095/A_study_to_evaluate_the_hepatoprotective_activity_of_prebiotics_probiotics_and_synbiotic_in_CCl4_induced_hepatotoxicity_in_rats">A study to evaluate the hepatoprotective activity of prebiotics, probiotics, and synbiotic in CCl4 induced hepatotoxicity in rats</a></div><div class="wp-workCard_item"><span>Journal of Applied Pharmaceutical Science</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The current study was evaluated for the hepatoprotective activity of probiotics, prebiotics alone...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The current study was evaluated for the hepatoprotective activity of probiotics, prebiotics alone, and synbiotic of them. Animals were grouped into 12 groups (n = 6), i.e. normal control (NC), disease control (DC), treatment with prebiotics, probiotics alone, and synbiotic of them, and standard marketed hepatoprotective Silymarin along with Synbiotic 2000. All treatments were orally administered daily for 28 days. On the 28th day, all animals except the NC group received carbon tetrachloride (CCl 4) (1 ml/kg, i.p.). Levels of serum glutamic pyruvic transaminase (SGPT), serum glutamicoxaloacetic transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin, total protein, lactate dehydrogenase, and urea were evaluated. The tissues were evaluated for oxidative markers levels of catalase (CAT), lipid peroxidation (LPO), and glutathione (GSH), and total protein. Histopathology of tissues was carried out. Compositional analysis of intestinal microbiota was done by 16S amplicon sequencing. CCl 4 caused elevation in SGPT, SGOT, ALP, total bilirubin, urea, and lactate dehydrogenase in the DC group which was prevented with pretreatment of prebiotics, probiotics, and synbiotics. Total protein was decreased in serum and tissues after administration of CCl 4 which was restored with pretreatment of test substances. Oxidative marker LPO was increased in the DC group and catalase (CAT) and GSH were also depleted in liver tissue. These changes were prevented in pretreated test groups. The histological change in hepatic parenchyma and hepatocytes was minimal in test groups compared to DC. The 16S amplicon sequencing indicated that Lactobacillus acidophilus and prebiotic treatment effectively displaced Staphylococcus. Results suggested that the use of prebiotics, probiotics alone, and synbiotic of them has a protective effect against CCl 4-induced hepatotoxicity in rats.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a5d2f3969f282792a45eddce775311fb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504615,"asset_id":121682095,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504615/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682095"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682095"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682095; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a5d2f3969f282792a45eddce775311fb" } } $('.js-work-strip[data-work-id=121682095]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121682095,"title":"A study to evaluate the hepatoprotective activity of prebiotics, probiotics, and synbiotic in CCl4 induced hepatotoxicity in rats","internal_url":"https://www.academia.edu/121682095/A_study_to_evaluate_the_hepatoprotective_activity_of_prebiotics_probiotics_and_synbiotic_in_CCl4_induced_hepatotoxicity_in_rats","owner_id":199490985,"coauthors_can_edit":true,"owner":{"id":199490985,"first_name":"Dr Kishori","middle_initials":null,"last_name":"Apte","page_name":"DrKishoriApte","domain_name":"independent","created_at":"2021-07-27T02:27:43.567-07:00","display_name":"Dr Kishori Apte","url":"https://independent.academia.edu/DrKishoriApte"},"attachments":[{"id":116504615,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116504615/thumbnails/1.jpg","file_name":"3317_pdf.pdf","download_url":"https://www.academia.edu/attachments/116504615/download_file","bulk_download_file_name":"A_study_to_evaluate_the_hepatoprotective.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116504615/3317_pdf-libre.pdf?1719836741=\u0026response-content-disposition=attachment%3B+filename%3DA_study_to_evaluate_the_hepatoprotective.pdf\u0026Expires=1740358225\u0026Signature=WZ0ygibdd2bm6OoHYFIJrQUtXFKZFlnxXB5mHypvarbt5h61htH5lCf63FfdfHbddi6SOs84rNeSZTzehMg1scXnUtrtU~wyS0N6QAf13Pk3qkTXz1D7DXrwfaiJe3p9~1OY91hPjq9aFln7mcZL8fDlWMu-0V0lUChXp2ppjGjlYiB74eoEr~NhKcmEjgnFiEVeTEYPhhehh3FNPZH4SWEj69Bcn9wI4OYLubeQ9W4qcSelKfhdiIie1N9MKCIV~qSaW-mbyQR2jCekVXphyNOjVrrzR6yKN-bA7gEGiw4kW-ZbgwKjkerCztT9I143LPg4X~S3Z3nPOG6YBZke8w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":116504614,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/116504614/thumbnails/1.jpg","file_name":"3317_pdf.pdf","download_url":"https://www.academia.edu/attachments/116504614/download_file","bulk_download_file_name":"A_study_to_evaluate_the_hepatoprotective.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/116504614/3317_pdf-libre.pdf?1719836728=\u0026response-content-disposition=attachment%3B+filename%3DA_study_to_evaluate_the_hepatoprotective.pdf\u0026Expires=1740358225\u0026Signature=YWyvseh1ZY7heWa5bD8VcVrYkfrSHsex2n36wWCfvelgDMRCMclEKsH9Hrv8x7SbMcYmyiD5xw-949ii02Kv4ESb21JTW9eKdvgZbb12bCNVQh67f3DxbElCHFGirVRhH9YsmWfoXeVROPkgN26sm2eL3x0SjcNN5Ou4TH3g~kum9tO6qPZBN7YFgBqej-xzGZDXZU9505pQC9VJ0WBccmNYu6g6O-vefIIlBp8aOzEVMavrGBZoH0A2EsR~hcM0vhCx1lxdJFqeia9D6m0oAiiHaTeuHbYFDzmnGbuvoq1Ij98JqcNYdmvBapfcjx4w6QfsPBmOShqVZyTdFIqupw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682094"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/121682094/Evaluation_of_Antiosteoporotic_potential_of_Sesbania_grandiflora_Linn_aqueous_fraction_in_Ovariectomised_Rats"><img alt="Research paper thumbnail of Evaluation of Antiosteoporotic potential of Sesbania grandiflora Linn. aqueous fraction in Ovariectomised Rats" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/121682094/Evaluation_of_Antiosteoporotic_potential_of_Sesbania_grandiflora_Linn_aqueous_fraction_in_Ovariectomised_Rats">Evaluation of Antiosteoporotic potential of Sesbania grandiflora Linn. aqueous fraction in Ovariectomised Rats</a></div><div class="wp-workCard_item"><span>Research Journal of Pharmacy and Technology</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Sesbania grandiflora (SG), an Indian herbal drug has been traditionally employed to treat or prev...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Sesbania grandiflora (SG), an Indian herbal drug has been traditionally employed to treat or prevent female related hormonal disorders and mitigating symptoms of menopausal conditions. The present study assessed the antiosteoporotic potential of the aqueous extract of Sesbania grandiflora on bone metabolism in ovariectomised (OVX) rat model and its safety in the uterus. Thirty Sprague-Dawley 6 months old female rats were randomly divided into 5 groups: Sham operated group and four OVX subgroups (n=6), that were undergone bilateral ovariectomy. OVX rats were further subdivided into vehicle, raloxifene 5.4mg/kg/day, Sesbania grandiflora aqueous leaf extracts–250mg/kg/day and 500mg/kg/day respectively. The pharmacological effects of the extract were evaluated against osteoporosis by body weight, uterus wet weight, serum and urine biochemical parameters, bone mineral density, biomechanical strength, trabecular microarchitecture, histomorphology and uterus immunohistochemistry. Daily oral administration of aqueous leaf extract significantly assuages the symptoms of ovariectomy as shown by decreased levels of serum ALP, TRAP, hydroxyproline and urinary calcium in the treatment groups. Moreover, improved femur parameters were seen as increased bone strength, BMD, trabecular bone mass and microarchitecture similar to raloxifene. Histopathological data also showed significant restorative progression with increased ossification and mineralization of trabecular bone, without uterine hypertrophy. The results suggests that Sesbania grandiflora had a remarkable antiosteoporotic activity and may be a promising candidate for treatment of postmenopausal osteoporosis induced by estrogen deficiency in a natural way through herbal resources.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682094"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682094"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682094; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682094]").text(description); $(".js-view-count[data-work-id=121682094]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121682094; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121682094']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="121682093"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/121682093/Oral_intake_of_polyphenols_of_Chromolaena_odorata_A_perspective_in_peptic_ulcer_thrombocytopenia_and_heparin_induced_bleeding_diathesis_in_rodent_model"><img alt="Research paper thumbnail of Oral intake of polyphenols of Chromolaena odorata: A perspective in peptic ulcer, thrombocytopenia, and heparin-induced bleeding diathesis in rodent model" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/121682093/Oral_intake_of_polyphenols_of_Chromolaena_odorata_A_perspective_in_peptic_ulcer_thrombocytopenia_and_heparin_induced_bleeding_diathesis_in_rodent_model">Oral intake of polyphenols of Chromolaena odorata: A perspective in peptic ulcer, thrombocytopenia, and heparin-induced bleeding diathesis in rodent model</a></div><div class="wp-workCard_item"><span>Pharmacognosy Research</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective: Bleeding disorder is of two types: external bleeding due to trauma, surgery, and inter...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective: Bleeding disorder is of two types: external bleeding due to trauma, surgery, and internal bleeding which happens mainly due to ulcers and thrombocytopenia or use of excessive anticoagulants. Proven hemostatic activity of Chromolaena odorata (L) in bleeding and wound healing had encouraged to evaluate the efficacy of aqueous extract and spray-dried powder (SDP) on ulcers, thrombocytopenia, and heparin-induced bleeding diathesis. Materials and Methods: Internal bleeding in the form of lesions in empty stomach was induced by absolute ethanol. Busulfan is administered through intraperitoneal injection to produce thrombocytopenia in Wistar rats and heparin at 1000 IU/ml was injected intravenous to mice, and after 30 min, tail was truncated to qualitatively and quantitatively differentiate the bleeding diathesis in treated versus nontreated controls. Results: A significant reduction in the lesions was observed in treated rats as compared to disease control rats which was evident from ulcer index and histopathology data. Considerable protection and production of platelets were observed in the thrombocytopenia model which was drastically reduced in the Busulfan administered disease control. Both aqueous extract and SDP were successful in preventing blood loss in heparin-induced tail-bleeding model. Conclusion: The presence of polyphenols attributes to the crucial role of C. odorata in arresting internal bleeding from stomach ulcer, protecting the thrombocytes from destroying, and minimizing the bleeding diathesis in mice. Abbreviations Used: SDP: Spray-dried powder, μL: Microliter, ml: Milliliter, nm: Nanometer, μg: Microgram, NAD: No abnormality detected, SD: Standard deviation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682093"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682093"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682093; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=121682093]").text(description); $(".js-view-count[data-work-id=121682093]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 121682093; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='121682093']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=121682093]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":121682093,"title":"Oral intake of polyphenols of Chromolaena odorata: A perspective in peptic ulcer, thrombocytopenia, and heparin-induced bleeding diathesis in rodent model","internal_url":"https://www.academia.edu/121682093/Oral_intake_of_polyphenols_of_Chromolaena_odorata_A_perspective_in_peptic_ulcer_thrombocytopenia_and_heparin_induced_bleeding_diathesis_in_rodent_model","owner_id":199490985,"coauthors_can_edit":true,"owner":{"id":199490985,"first_name":"Dr Kishori","middle_initials":null,"last_name":"Apte","page_name":"DrKishoriApte","domain_name":"independent","created_at":"2021-07-27T02:27:43.567-07:00","display_name":"Dr Kishori Apte","url":"https://independent.academia.edu/DrKishoriApte"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682092"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/121682092/Role_of_Adiantum_philippense_L_on_glucose_uptake_in_isolated_pancreatic_cells_and_inhibition_of_adipocyte_differentiation_in_3T3_L1_cell_line"><img alt="Research paper thumbnail of Role of Adiantum philippense L. on glucose uptake in isolated pancreatic cells and inhibition of adipocyte differentiation in 3T3-L1 cell line" class="work-thumbnail" src="https://attachments.academia-assets.com/116504651/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/121682092/Role_of_Adiantum_philippense_L_on_glucose_uptake_in_isolated_pancreatic_cells_and_inhibition_of_adipocyte_differentiation_in_3T3_L1_cell_line">Role of Adiantum philippense L. on glucose uptake in isolated pancreatic cells and inhibition of adipocyte differentiation in 3T3-L1 cell line</a></div><div class="wp-workCard_item"><span>Pharmacognosy Magazine</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Adiantum philippense (AP) is a pteridophyte that shows antihyperglycemic activity in ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Adiantum philippense (AP) is a pteridophyte that shows antihyperglycemic activity in vivo diabetic model, but the mechanism of action is unknown. Objective: AP was found to play a pivotal role in minimizing the high blood glucose in alloxan-induced diabetic rats. Simultaneously, it was observed that it could maintain the normal lipid profile even in diabetic condition. To investigate its insulin-like activity along with its inhibitory role on adipocyte differentiation became the objective of our present study. Materials and Methods: Glucose uptake potential of this fern was done in isolated pancreatic islets and inhibition of adipocyte differentiation was assessed in 3T3-L1 cell line. Before this, the cytotoxic concentration was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on L929 cell line. To determine its role in lipid metabolism, the oil droplets produced in adipocytes were stained with Oil 'O' red staining, and triglyceride levels of various drug treatments were measured spectrophotometrically. Results: This fern extract was found to be actively utilizing glucose in the glucose uptake assay. Moreover, it was also involved in inhibiting differentiation of pro-adipocyte to adipocyte in the 3T3-L1 cell lines. The percentage inhibition as obtained from the absorbance showed that the ethanolic extract at the concentration of 200 µg/ml showed 32.48% inhibition. Conclusion: All the above-mentioned parameters when appraised indicated that this fern could be used as an alternative medicine in managing diabetes associated with obesity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0833c6f6bd43c220dba0da23bb5641be" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":116504651,"asset_id":121682092,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/116504651/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682092"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682092"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682092; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="121682091"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/121682091/A_preliminary_study_on_anti_inflammatory_activity_and_antioxidant_property_of_Lygodium_flexuosum_a_climbing_fern"><img alt="Research paper thumbnail of A preliminary study on anti-inflammatory activity & antioxidant property of Lygodium flexuosum, a climbing fern" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/121682091/A_preliminary_study_on_anti_inflammatory_activity_and_antioxidant_property_of_Lygodium_flexuosum_a_climbing_fern">A preliminary study on anti-inflammatory activity & antioxidant property of Lygodium flexuosum, a climbing fern</a></div><div class="wp-workCard_item"><span>International Journal of Pharmacy and Pharmaceutical Sciences</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT Export Date: 18 October 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="121682091"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="121682091"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 121682091; 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