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Search results for: Ramendeep Grawal
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style="font-size:1.6rem;">Search results for: Ramendeep Grawal</h1> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Extended Release System of Hypoglycemic Agent Containing Solid Dispersions: Strategies and Mechanisms</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Amit%20Kumar">Amit Kumar</a>, <a href="https://publications.waset.org/search?q=Ramendeep%20Grawal"> Ramendeep Grawal</a>, <a href="https://publications.waset.org/search?q=Peeyush%20Sharma"> Peeyush Sharma</a>, <a href="https://publications.waset.org/search?q=Dinesh%20Puri"> Dinesh Puri</a>, <a href="https://publications.waset.org/search?q=Anil%20Bhandari"> Anil Bhandari</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>The main perspective of the present study aims at overcoming solubility problems by using the technique of solid dispersion. Repaglinide is a BCS Class II drug, having low aqueous solubility and therefore, low bioavailability. Solid dispersions of repaglinide with different carriers Polyvinyl Pyrrolidone (PVP) and Ethyl Cellulose (EC) in different ratios were prepared by suspending method and Dissolving methods. <em>In vitro </em>release studies revealed that the F7 formulation showed extended drug release. So, the dissolution profile of solid dispersion containing EC and PVP K30 (1: 3) was selected as the best formulation because of its extended drug release among all formulations. In conclusion, solid dispersions of Repaglinide in PVP have shown to be a promising approach to improve the bioavailability of Repaglinide.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Ethyl%20Cellulose" title="Ethyl Cellulose">Ethyl Cellulose</a>, <a href="https://publications.waset.org/search?q=Glibenclamide" title=" Glibenclamide"> Glibenclamide</a>, <a href="https://publications.waset.org/search?q=Polyvinyl%20Pyrrolidone" title=" Polyvinyl Pyrrolidone"> Polyvinyl Pyrrolidone</a>, <a href="https://publications.waset.org/search?q=Repaglinide" title=" Repaglinide"> Repaglinide</a>, <a href="https://publications.waset.org/search?q=Solid%20Dispersion." title=" Solid Dispersion."> Solid Dispersion.</a> </p> <a href="https://publications.waset.org/9997725/extended-release-system-of-hypoglycemic-agent-containing-solid-dispersions-strategies-and-mechanisms" class="btn btn-primary btn-sm">Procedia</a> <a 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