Document Zbl 1545.62250

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Med.</a> <a href="/?q=in%3A518884" title="Articles in this Issue">42, No. 9, 1368-1397 (2023)</a>. </div> <div class="abstract"></div> <div class="clear"></div> <br> <div class="citations"><div class="clear"><a href="/?q=rf%3A7925009">Cited in <strong>1</strong> Document</a></div></div> <div class="classification"> <h3>MSC:</h3> <table><tr> <td> <a class="mono" href="/classification/?q=cc%3A62P10" title="MSC2020">62P10</a> </td> <td class="space"> Applications of statistics to biology and medical sciences; meta analysis </td> </tr></table> </div><div class="keywords"> <h3>Keywords:</h3><a href="/?q=ut%3Aestimands">estimands</a>; <a href="/?q=ut%3Ageneralized+transformation+model">generalized transformation model</a>; <a href="/?q=ut%3Aintercurrent+events">intercurrent events</a>; <a href="/?q=ut%3Arobustness">robustness</a>; <a href="/?q=ut%3Asemi-competing+risks">semi-competing risks</a></div> <div class="software"> <h3>Software:</h3><a href="/software/11207">invGauss</a></div>  <div class="modal fade" id="metadataModal" tabindex="-1" role="dialog" aria-labelledby="myModalLabel"> <div class="modal-dialog" role="document"> <div class="modal-content"> <div class="modal-header"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> <h4 class="modal-title" id="myModalLabel">Cite</h4> </div> <div class="modal-body"> <div class="form-group"> <label for="select-output" class="control-label">Format</label> <select id="select-output" class="form-control" aria-label="Select Metadata format"></select> </div> <div class="form-group"> <label for="metadataText" class="control-label">Result</label> <textarea class="form-control" id="metadataText" rows="10" style="min-width: 100%;max-width: 100%"></textarea> </div> <div id="metadata-alert" class="alert alert-danger" role="alert" style="display: none;">  </div> </div> <div class="modal-footer"> <button type="button" class="btn btn-primary" onclick="copyMetadata()">Copy to clipboard</button> <button type="button" class="btn btn-default" data-dismiss="modal">Close</button> </div> </div> </div> </div> <div class="functions clearfix"> <div class="function">  <a type="button" class="btn btn-default btn-xs pdf" data-toggle="modal" data-target="#metadataModal" data-itemtype="Zbl" data-itemname="Zbl 1545.62250" data-ciurl="/ci/07925009" data-biburl="/bibtex/07925009.bib" data-amsurl="/amsrefs/07925009.bib" data-xmlurl="/xml/07925009.xml" > Cite </a> <a class="btn btn-default btn-xs pdf" data-container="body" type="button" href="/pdf/07925009.pdf" title="Zbl 1545.62250 as PDF">Review PDF</a> </div> <div class="fulltexts"> <span class="fulltext">Full Text:</span> <a class="btn btn-default btn-xs" type="button" href="https://doi.org/10.1002/sim.9675" aria-label="DOI for “Multistate models as a framework for estimand specification in clinical trials of complex processes”" title="10.1002/sim.9675">DOI</a> <a class="btn btn-default btn-xs" type="button" href="https://arxiv.org/abs/2209.13658"title="Note: arXiv document may differ from published version">arXiv</a> </div> <div class="sfx" style="float: right;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" title="Open Access License" class="cc-license-link no-new-tab-icon"> <img src="https://static.zbmath.org/contrib/img/cc/svg/icons/cc.svg" alt="Creative Commons CC license icon" class="cc-license-icon"> <img src="https://static.zbmath.org/contrib/img/cc/svg/icons/by.svg" alt="Creative Commons BY license icon" class="cc-license-icon"> </a> </div> </div> <div class="references"> <h3>References:</h3> <table><tr> <td>[1]</td> <td class="space">Booth, CM; Eisenhauer, EA, Progression‐free survival: meaningful or simply measurable?, J Clin Oncol, 30, 10, 1030-1033, 2012</td> </tr><tr> <td>[2]</td> <td class="space">Rufibach, K., Treatment effect quantification for time‐to‐event endpoints-Estimands, analysis strategies, and beyond, Pharm Stat, 18, 2, 145-165, 2019</td> </tr><tr> <td>[3]</td> <td class="space">Furberg, JK; Rasmussen, S.; Andersen, PK; Ravn, H., Methodological challenges in the analysis of recurrent events for randomised controlled trials with application to cardiovascular events in LEADER, Pharm Stat, 21, 1, 241-267, 2022</td> </tr><tr> <td>[4]</td> <td class="space">Toenges, G.; Mütze, T.; Jahn‐Eimermacher, A., A comparison of semiparametric approaches to evaluate composite endpoints in heart failure trials, Stat Med, 40, 26, 5702-5724, 2021 · <a href="/1546.62753" class="nowrap">Zbl 1546.62753</a></td> </tr><tr> <td>[5]</td> <td class="space">Qu, Y.; Shurzinske, L.; Sethuraman, S., Defining estimands using a mix of strategies to handle intercurrent events in clinical trials, Pharm Stat, 20, 2, 314-323, 2021</td> </tr><tr> <td>[6]</td> <td class="space">Committee, IES, ICH E9 (R1): addendum to statistical principles for clinical trials on choosing appropriate estimands and defining sensitivity analyses in clinical trials. 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