CINXE.COM

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container"><div class="region region-content"><div id="block-system-main" class="block block-system clearfix"><div class="content"><div id="node-110398" class="node node-product-sub-category page-node- node-type-product-category" about="/rnascope-ls-multiplex-fluorescent-assay" typeof="sioc:Item foaf:Document"><div class="nav-tab-container"><ul class="nav nav-tabs page-tabs" id="myTab"><li><a href="/automated-assay-leica">Overview</a></li><li class="pro-category-20224" ><a href="/rnascope-25-ls-assay-brown">RNAscope 2.5 LS Assay-BROWN</a></li><li class="pro-category-20225" ><a href="/rnascope-25-ls-assay-red">RNAscope 2.5 LS Assay-RED</a></li><li class="pro-category-104792" ><a href="/rnascope-25-ls-duplex-assay">RNAscope 2.5 LS Duplex Assay</a></li><li class="pro-category-480623" ><a href="/rnascope-multiomic-ls-fluorescent-assay">RNAscope™ Multiomic LS Fluorescent Assay</a></li><li class="active pro-category-110398"><a href="/rnascope-ls-multiplex-fluorescent-assay" class="active">RNAscope LS Multiplex Fluorescent Assay</a></li><li class="pro-category-138442" ><a href="/rnascope-25-lsx-reagent-kit-brown">RNAscope 2.5 LSx Reagent Kit-BROWN</a></li><li class="pro-category-193472" ><a href="/rnascope-25-lsx-reagent-kit-red-0">RNAscope 2.5 LSx Reagent Kit-RED</a></li><li class="pro-category-246248" ><a href="/basescope-ls-reagent-kit-%E2%80%93-red">BaseScope LS Reagent Kit – RED</a></li><li class="pro-category-425267" ><a href="/mirnascope-ls-reagent-kit-red">miRNAscope LS Reagent Kit Red</a></li><li class="pro-category-464323" ><a href="/rnascopepluslsassay">RNAscopePlusLSAssay</a></li></ul></div><div class="tab-content"><div id="tab0" class="tab-pane fade in active profile"><div class="sample-image"><div class="profile-content"><h3>RNAscope™ LS Multiplex Fluorescent Assay</h3></div><div class="loader-image-gallery"></div><div id="film_roll" class="sample-slider"><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/Expression%20of%20Hs-TNFSF4%20%28OX40L%29%20%28green%29%2C%20CD274%20%28PDL1%29%20%28red%29%20and%20HAVCR2%20%28TIM3%29%20%28white%29%20using%20RNAscope%20LS%20multiplex%20Fluorescent%20assay_0.jpg" width="765" height="451" alt="Expression of Hs-TNFSF4 (OX40L) (green), CD274 (PDL1) (red) and HAVCR2 (TIM3) (white) using RNAscope LS multiplex Fluorescent assay (RNA in situ hybridization ISH)" /><p class="slider-below-text"> RNA expression of TNFSF4 (OX40L) (green), CD274 (PDL1) (red) and HAVCR2 (TIM3) (white) using RNAscope LS Multiplex Fluorescent Assay</p></div><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/Expression%20of%20MALAT1%20%28red%29%20and%20Mog%20%28white%29%20using%20RNAscope%20LS%20multiplex%20Fluorescent%20assay_0.jpg" width="765" height="451" alt="Expression of MALAT1 (red) and Mog (white) using RNAscope LS multiplex Fluorescent assay(RNA in situ hybridization ISH)" /><p class="slider-below-text"> RNA expression of Malat1 (red, high in nuclear) and Mog (white) in fresh frozen rat brain tissue using RNAscope LS multiplex Fluorescent Assay.</p></div><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/Positive%20control%20probes%20demonstrate%20expression%20of%20Tbp%20%28green%29%2C%20PPib%20%28red%29%20and%20UBC%20%28white%29%20in%20Mouse%20Brain%20Fresh%20Frozen_0_0.jpg" width="765" height="451" alt="Positive control probes demonstrate expression of Tbp (green), PPib (red) and UBC (white) in Mouse Brain Fresh Frozen(RNA in situ hybridization ISH)" /><p class="slider-below-text"> Positive control probes demonstrate RNA expression of Tbp (green), PPib (red) and UBC (white) in mouse brain fresh frozen tissue using RNAscope LS Multiplex Fluorescent Assay</p></div><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/RNA%20ISH%20Expression%20of%20CD3D%20%20%28green%29%20CD8A%20%28red%29%20combined%20%20with%20IHC%20of%20CDC%20%28white%29%20using%20RNAscope%20LS%20multiplex%20Fluorescent%20assay%20in%20FFPE%20human%20tonsil_0.jpg" width="765" height="451" alt="RNA ISH Expression of CD3D (green) CD8A (red) combined with IHC of CDC (white) using RNAscope LS multiplex Fluorescent assay in FFPE human tonsil(RNA in situ hybridization ISH)" /><p class="slider-below-text"> RNA expression of CD3D (green) CD8A (red) combined with protein expression of CDC (white) (IHC) in human tonsil FFPE tissue using RNAscope LS Multiplex Fluorescent assay</p></div><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/Expression%20of%20Mm-Sc17a6-C1%20%28Vglut2%29%20%20%28green%29%2C%20Mm-Slc17a7-C2%20%28Vlgut1%29%20%28red%29%20and%20Mm-Slc32a1-C3%20%28Vgat%29_0.jpg" width="765" height="451" alt="Expression of Mm-Sc17a6-C1 (Vglut2) (green), Mm-Slc17a7-C2 (Vlgut1) (red) and Mm-Slc32a1-C3 (Vgat)(RNA in situ hybridization ISH) " /><p class="slider-below-text"> RNA expression of Sc17a6-C1 (Vglut2) (green), Slc17a7-C2 (Vlgut1) (red) and Slc32a1-C3 (Vgat) in mouse brain fresh frozen tissue using RNAscope LS Multiplex Fluorescent Assay</p></div><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/Expression%20of%20Mm-Cnr1%28green%29%2C%20Mm-Drd1%20%28red%29%20and%20Mm-Nmdar1%20%28white%29%20in%20mouse%20brain%20FFPE%20tissue%20using%20RNAscope%20LS%20multiplex%20Fluorescent%20assay_0.jpg" width="765" height="451" alt="Expression of Mm-Cnr1(green), Mm-Drd1 (red) and Mm-Nmdar1 (white) in mouse brain FFPE tissue using RNAscope LS multiplex Fluorescent assay(RNA in situ hybridization ISH) " /><p class="slider-below-text"> RNA expression of Cnr1(green), Drd1 (red) and Nmdar1 (white) in mouse brain FFPE tissue using RNAscope LS Multiplex Fluorescent Assay</p></div><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/Expression%20of%20Mm-Sc17a6%20%28Vglut2%29%28green%29%2C%20Mm-SLc17a7%20%28Vlgut1%29%20%28red%29%20and%20Mm-Slc32a1%20%28white%29%20in%20mouse%20brain%20fresh%20frozen%20tissue%20using%20RNAscope%20LS%20multiplex%20Fluorescent%20assay_0.jpg" width="765" height="451" alt="Expression of Mm-Sc17a6 (Vglut2)(green), Mm-SLc17a7 (Vlgut1) (red) and Mm-Slc32a1 (white) in mouse brain fresh frozen tissue using RNAscope LS multiplex Fluorescent assay(RNA in situ hybridization ISH)" /><p class="slider-below-text"> RNA expression of Sc17a6 (Vglut2)(green), SLc17a7 (Vlgut1) (red) and Slc32a1 (white) in mouse brain fresh frozen tissue using RNAscope LS Multiplex Fluorescent Assay</p></div><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/Expression%20of%20HPV%20HR18%28green%29%2C%20Hs-CDKN2A%20%28p16%29%20%28red%29%20and%20Hs-MKI67%28white%29%20in%20human%20head%20and%20neck%20cancer%20FFPE%20tissue%20using%20RNAscope%20LS%20multiplex%20Fluorescent%20assay_0.jpg" width="765" height="451" alt="Expression of HPV HR18(green), Hs-CDKN2A (p16) (red) and Hs-MKI67(white) in human head and neck cancer FFPE tissue using RNAscope LS Multiplex Fluorescent Assay(RNA in situ hybridization ISH)" /><p class="slider-below-text"> RNA expression of HPV HR18(green), Hs-CDKN2A (p16) (red) and Hs-MKI67(white) in human head and neck cancer FFPE tissue using RNAscope LS Multiplex Fluorescent Assay</p></div><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/Expression%20of%20Hs-KRT19%28green%29%2C%20Hs-PECAM1%20%28red%29%20and%20Hs-MKI67%28white%29%20in%20human%20breast%20cancer%20FFPE%20tissue%20using%20RNAscope%20LS%20multiplex%20Fluorescent%20assay_0.jpg" width="765" height="451" alt="Expression of Hs-KRT19(green), Hs-PECAM1 (red) and Hs-MKI67(white) in human breast cancer FFPE tissue using RNAscope LS multiplex Fluorescent assay(RNA in situ hybridization ISH)" /><p class="slider-below-text"> RNA expression of KRT19(green), PECAM1 (red) and MKI67(white) in human breast cancer FFPE tissue using RNAscope LS Multiplex Fluorescent Assay</p></div><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/RNA%20ISH%20Expression%20of%20CD8A%20%20%28green%29%20CD274%20%28red%29%20combined%20%20with%20IHC%20of%20CD8%20%28white%29%20using%20RNAscope%20LS%20multiplex%20Fluorescent%20assay%20in%20human%20lung%20cancer%20FFPE%20sample_0.jpg" width="765" height="451" alt="RNA expression of CD8A (green) CD274 (red) combined with IHC of CD8 (white) using RNAscope LS multiplex Fluorescent assay in human lung cancer FFPE sample(RNA in situ hybridization ISH)" /><p class="slider-below-text"> RNA expression of CD8A (green) CD274 (red) combined with protein expression of CD8 (white, IHC) in human lung cancer FFPE sample using RNAscope LS Multiplex Fluorescent Assay</p></div><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/Expression%20of%20Hs-TNFSF4%20%28OX40L%29%28green%29%2C%20Hs-CD274%20%28PDL1%29%20%28red%29%20and%20Hs-HAVCR2%20%28TIM3%29%20%28white%29in%20human%20lung%20cancer%20FFPE%20tissue%20using%20RNAscope%20LS%20multiplex%20Fluorescent%20assay_0.jpg" width="765" height="451" alt="Expression of Hs-TNFSF4 (OX40L)(green), Hs-CD274 (PDL1) (red) and Hs-HAVCR2 (TIM3) (white)in human lung cancer FFPE tissue using RNAscope LS multiplex Fluorescent assay(RNA in situ hybridization ISH)" /><p class="slider-below-text"> RNA expression of TNFSF4 (OX40L)(green), CD274 (PDL1) (red) and HAVCR2 (TIM3) (white)in human lung cancer FFPE tissue using RNAscope LS Multiplex Fluorescent Assay</p></div><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/Expression%20of%20Hs-CXCL13%20%28green%29%2C%20Hs-CD274%20%28PDL1%29%20%28red%29%20and%20Hs-KRT%609-C3%20%28white%29%20in%20human%20lung%20cancer%20FFPE%20tissue%20using%20RNAscope%20LS%20multiplex%20Fluorescent%20assay_0.jpg" width="765" height="451" alt="RNA expression of CXCL13 (green), CD274 (PDL1) (red) and KRT`9-C3 (white) in human lung cancer FFPE tissue using RNAscope LS Multiplex Fluorescent Assay" /><p class="slider-below-text"> RNA expression of CXCL13 (green), CD274 (PDL1) (red) and KRT`9-C3 (white) in human lung cancer FFPE tissue using RNAscope LS Multiplex Fluorescent Assay</p></div><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/Expression%20of%20Hs-IDO1%20%28green%29%2C%20Hs-CD274%20%28PDL1%29%28red%29%20and%20Hs-CTLA4%20%28white%29in%20human%20lung%20cancer%20FFPE%20tissue%20using%20RNAscope%20LS%20multiplex%20Fluorescent%20assay_0_0.jpg" width="765" height="451" alt="Expression of Hs-IDO1 (green), Hs-CD274 (PDL1)(red) and Hs-CTLA4 (white)in human lung cancer FFPE tissue using RNAscope LS multiplex Fluorescent assay(RNA in situ hybridization ISH)" /><p class="slider-below-text"> RNA expression of IDO1 (green), CD274 (PDL1)(red) and CTLA4 (white)in human lung cancer FFPE tissue using RNAscope LS Multiplex Fluorescent Assay</p></div><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/Lung%20cancer%20FFPE_0.jpg" width="765" height="451" alt="Lung cancer FFPE(RNA in situ hybridization ISH) " /><p class="slider-below-text"> RNA expression of PTPRC (CD45) (green), IFNG (red) and of CD274 (PDL1) (white) in human lung cancer FFPE tissue using RNAscope LS Multiplex Fluorescent Assay</p></div></div><style type="text/css"> .loader-image-gallery { position: absolute; left: 0px; top: 0px; width: 100%; height: 100%; z-index: 9999; background: url('/sites/default/files/loading_apple.gif') 50% 35% no-repeat rgb(249,249,249); background-size: 100px; opacity: .8; } .sample-image { position: relative; } </style> <script type="text/javascript"> jQuery(document).ready(function($) { // $('#film_roll').hide(); function preloader(){ $('.loader-image-gallery').hide(); $('#film_roll').show(); } window.onload = preloader; }); </script> <div class="profile-content"> <article class="read-more"><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><p>Designed as an automated assay on the <a href="https://www.leicabiosystems.com/ihc-ish-fish/ihc-ish-instruments/details/product/leica-bond-rx/">Leica Biosystems' BOND RX Research Advanced Staining System</a>, this new assay enables single-molecule detection of up to four RNA targets simultaneously. Ideal for co-localization and co-expression studies, the assay and RNAscope LS 2.5 Probes are available for <span>application in your own lab and via </span><a href="http://acdbio.com/PAS">ACD's Professional Assay Services</a>. </p><p>The key technological advantage of this assay is the <strong>significant signal boost </strong><span><strong>with simultaneous background noise suppression</strong> which is due to advances in ACD’s patented signal amplification technology combined with the Tyramide Signal Amplification <a href="http://www.perkinelmer.com/lab-solutions/resources/docs/BRO_TSAsignalamplification1.pdf">(TSA</a></span><a href="http://www.perkinelmer.com/lab-solutions/resources/docs/BRO_TSAsignalamplification1.pdf">™</a><span><a href="http://www.perkinelmer.com/lab-solutions/resources/docs/BRO_TSAsignalamplification1.pdf">)</a> technology. Furthermore the signal sensitivity is balanced across all three channels. These technological advances enable</span>: </p><ul><li><strong>Strong detection of low expressors</strong>- Vivid visualization of even very low expressing genes in any of the three probe channels</li><li><span><strong>Compatible with multiple sample types</strong>- Detection of signals at low exposure and supports of FFPE samples and fresh frozen samples</span></li><li><strong>Supports dual ISH and IHC protocols</strong>- High and stable signals enable sequential detection of proteins by IHC on the same samples. See<span> <a href="https://acdbio.com/science/applications/rna-ish-ihc/dual-ish-and-ihc">Dual ISH & IHC</a> for protocols.</span></li><li><strong>Easy to use</strong>-<span> No need to match expression level of targets with channel sensitivity</span></li><li><strong>Sharper, crisper signal</strong>- Strong balanced signals across all three channels make it easy to generate publication-quality data.</li></ul><p> </p><p><em>"I was very impressed with the quality of work and quick turn-around of the Professional Assay Services group. The data generated using RNAscope LS Multiplex kit gave us enough information to proceed further with our study. It allowed us to co-localize our target RNA along with different cell type specific RNA markers to determine in which CNS cell types the target was expressed.”</em></p><p><strong>Curt Mazur</strong></p><p>Director, Neuroscience Drug Discovery; Ionis Pharmaceuticals, Inc.</p></div></div></div> </article></div><div class="profile-bottom"><div class="multi-flurocent-array"><h2>Technology Overview</h2><div class="read-more"><p>RNAscope LS Multiplex Fluorescent Assay allows simultaneous detection of up to four RNA targets within a single sample using up to four target probes and the nuclei can be counter stained and visualized using DAPI fluorescent dye. The four target probes, each designed a different probe channel - C1, C2, C3 or C4, contain several components. The lower part of the double Z probe is designed to hybridize to a specific RNA target. The upper part of the double Z probe, along with the preamplifiers, amplifiers and dyes are assigned to a specific probe channel. Signal detection is performed by Tyramide linked Fluorescein, Cy3 and Cy5 dyes. The sequential assay workflow provides flexibility to visualize any probe in any of the TSA linked fluorophore channels. The combination of ACD patented signal amplification system and the tyramide technology provides a significant boost in the signal while suppressing background noise. This feature makes the assay suitable for use on both FFPE and fresh-frozen samples.  It is ideal for co-localization applications and compatible with dual ISH IHC protocols.</p><p><img alt="" src="/sites/default/files/Multiplex_FarRedRedYellowGreen.png" /></p></div><p> </p><h2>Guidelines for Microscope Channel Selection</h2><p>The RNAscope LS Multiplex Fluorescent Assay supports interrogation of up to 4 target probes, each designed in a separate probe channel C1, C2, C3 and C4, which are visible in the filters associated with the dyes such as FITC, Cy3, Cy5 and Texas Red. The signal amplification in all 4 channels is balanced, removing the necessity of selecting channels based on gene-specific expression level. Customers can freely select channels for their genes. For viewing of 4 plex assay, a multiplexed biomarker imaging system is required, such as Nuance FX Multiplex Biomarker Imaging System, Vectra 3.0 Automated Quantitative Pathology Imaging System or Mantra Quantitative Pathology Workstation from Perkin Elmer.</p><p> </p><div class="classification"><table align="center" border="1" cellpadding="1" cellspacing="1"><thead><tr><th><strong>3-plex fluorophore</strong></th><th><strong>3-plex filter</strong></th><th><strong style="text-align: center;">4-plex fluorophore </strong></th><th><strong style="text-align: center;">4-plex filter</strong></th></tr></thead><tbody><tr><td><p>TSA Vivid 520/Opal 520</p><p>TSA Vivid 570/Opal 570</p><p>TSA Vivid 650/Opal 690</p><p> </p></td><td><p>FITC/GFP</p><p>Cy3</p><p>Cy5</p><p> </p></td><td><p>Opal 520</p><p>Opal 570</p><p>Opal 620</p><p>Opal 690</p></td><td><p>FITC/GFP</p><p>Cy3</p><p>Texas Red</p><p>Cy5</p></td></tr></tbody></table></div><p> </p><h2>What to order</h2><div class="read-more nospace"><p>Visualization requires a multispectral fluorescent imaging system (e.g. Nuance FX Multiplex Biomarker Imaging System)</p><p><strong style="padding:0">Order the following components from ACD:</strong></p><div class="classification"><table align="center" border="1" cellpadding="1" cellspacing="1"><thead><tr><th><strong>Component</strong></th><th><strong>Cat. No.</strong></th><th>Description</th></tr></thead><tbody><tr><td>RNAscope™ LS Multiplex Fluorescent Reagent Kit with TSA Vivid Dyes </td><td>323275</td><td>RNAscope LS (Leica Biosystems) Multiplex assay TSA Vivid Dyes is a RNA <em>in situ</em> hybridization (ISH) fluorescent assay for use of three fluorescent dyes for single plex, duplex and up to 3-plex capability with the Leica Biosystems BOND RX automated IHC/ISH slide staining systems (Note: Using Leica Software v BDZ 11). The kit includes the pretreatment, TSA buffer (322810), and  detection reagents for automated amplification and TSA Vivid Fluorophore 520 (PN 323271), TSA Vivid Fluorophore 570 (PN 323272) and TSA Vivid Fluorophore 650 (PN 323273). . Each reagent kit provides enough reagents to stain ~60 slides. Leica Research Kit (DS9455) , is also required to run the RNAscope Multiplex Fluorescent Kit.</td></tr><tr><td><p><strong style="padding:0">RNAscope LS Multiplex Reagent Kit</strong></p><p>Contains pretreatment reagents, TSA buffer (322810) and detection reagents for ~60 slides</p><p>This kit is required for 3-plex and 4-plex</p></td><td><p>322800</p></td><td> </td></tr><tr><td><p><strong style="padding: 0px;">RNAscope LS 4-Plex Ancillary Kit  Multiplex Reagent Kit</strong></p><p>Designed to work with the RNAscope LS Multiplex Fluorescent Reagent Kit (Cat. No. 322800), C1, C2, C3 and C4 Channel Target Probes for 4 plex fluorescent <em>in situ</em> hybridization. It contains HRP-C4 and HRP blocker. </p></td><td><p>322830</p></td><td> </td></tr><tr><td colspan="2"><table><tbody><tr><td><p><strong style="padding:0">RNAscope LS 2.5 Target Probes</strong></p><p>(Catalog or Made-to-Order C1, C2, C3 & C4 LS 2.5 Probes)</p></td><td> </td></tr><tr><td><p>300038 RNAscope 2.5 LS Probe (RTU)</p></td><td><p>300038</p></td></tr><tr><td><p>300038-C2 RNAscope 2.5 LS Probe- C2 (50x)</p></td><td><p>300038-C2</p></td></tr><tr><td><p>300038-C3 RNAscope 2.5 LS Probe- C3 (50x)</p></td><td><p>300038-C3</p></td></tr><tr><td><p>300038-C4 RNAscope 2.5 LS Probe- C4 (50x)</p></td><td><p>300038-C4</p></td></tr></tbody></table></td><td> </td></tr><tr><td colspan="2"><table><tbody><tr><td><p><strong style="padding:0">RNAscope LS 2.5 Positive Control Probes</strong></p><p>Select species-specific positive control C1, C2 & C3<br />probes and negative control probes</p></td><td> </td></tr><tr></tr><tr><td><p>320868 - RNAscope 3-plex LS Multiplex Control Positive Probe- Hs POLR2A (C1), PPIB (C2), UBC(C3)</p></td><td><p>320868</p></td></tr><tr><td><p>320888 - RNAscope 3-plex LS Multiplex Control Positive Probe - Mm polr2A (C1), ppib(C2), ubc(C3)</p></td><td><p>320888</p></td></tr><tr><td><p>320838 - RNAscope 3-plex LS Multiplex Control Positive Probe - HeLa Cells TBP (C1), PPIB (C2), POLR2A (C3)</p></td><td><p>320838</p></td></tr><tr><td><p>RNAscope 4-plex LS Multiplex Control Positive Probe - POLR2A (C1), PPIB (C2), UBC (C3) and HPRT-1 (C4)</p><p>In terms of relative expression levels, UBC is the highest, PPIB is considered a moderate-high, HPRT-1 and POLR2A are moderate-to low expressor target.</p></td><td><p> </p><p> </p></td></tr><tr><td><p>321808 - RNAscope 4-plex LS Multiplex Control Positive Probe -Hs</p></td><td>321808</td></tr><tr><td><p>321818 - RNAscope 4-plex LS Multiplex Control Positive Probe -Mm</p></td><td>321818</td></tr><tr><td><p>321828 - RNAscope 4-plex LS Multiplex Control Positive Probe -Rn</p></td><td>321828</td></tr></tbody></table><p> </p></td><td> </td></tr><tr><td colspan="2"><table><tbody><tr><td><p><strong style="padding:0">RNAscope LS 2.5 Negative Control Probes</strong></p></td><td> </td></tr><tr><td><p>RNAscope 3-plex LS Multiplex Negative Control  Probe dapB in all 3 channels</p></td><td><p>320878</p></td></tr><tr><td><p>RNAscope 4-plex LS Multiplex Negative Control  Probe dapB in all 4 channels</p></td><td><p>321838</p></td></tr></tbody></table></td><td> </td></tr><tr><td><p><strong style="padding:0">RNAscope Control Slides (optional)</strong></p><p>Human Cell Pellet or Mouse 3T3 Cell Pellet</p></td><td><p> </p><p><a href="https://acdbio.com/search/site/310045/cms/product">310045</a> </p><p><a href="https://acdbio.com/search/site/310023/cms/product">310023</a></p></td><td> </td></tr></tbody></table></div><p></p><p><strong>Order the following components</strong><strong>:</strong></p><div class="classification"><table align="center" border="1" cellpadding="1" cellspacing="1"><thead><tr><th><strong>Component</strong></th><th><strong>Product Number</strong></th><th>Product Description</th></tr></thead><tbody><tr><td><p>TSA Plus Fluorescein System for 50-150 Slides</p><p>ACD Multiple TSA-F1</p></td><td><p>NEL741001KT</p><p>NEL741B001KT</p></td><td> </td></tr><tr><td><p>TSA Plus Cyanine 3 System for 50-150 Slides</p><p>ACD Multiple TSA-F2</p></td><td><p>NEL744001KT</p><p>NEL744B001KT</p></td><td> </td></tr><tr><td><p>TSA Plus Cyanine 5 System for 50-150 Slides</p><p>ACD Multiple TSA-F3</p></td><td><p>NEL745001KT</p><p>NEL745B001KT</p></td><td> </td></tr><tr><td><p>TSA Vivid Fluorophore 520</p></td><td><p>323271</p></td><td>TSA Vivid™ reagents are exceptionally bright dyes that offer an effective way to boost signal intensity and detect low-abundance targets in spatial biology applications. Contains  1x vial TSA Vivid fluorophore 520 and 1x vial DMSO</td></tr><tr><td><p>TSA Vivid Fluorophore 570</p></td><td><p>323272</p></td><td>TSA Vivid™ reagents are exceptionally bright dyes that offer an effective way to boost signal intensity and detect low-abundance targets in spatial biology applications. Contains  1x vial TSA Vivid fluorophore 570 and 1x vial DMSO</td></tr><tr><td><p>TSA Vivid Fluorophore 650</p></td><td><p>323273</p></td><td>TSA Vivid™ reagents are exceptionally bright dyes that offer an effective way to boost signal intensity and detect low-abundance targets in spatial biology applications. Contains  1x vial TSA Vivid fluorophore 650 and 1x vial DMSO</td></tr><tr><td>Opal 520 Reagent Pack</td><td><p>FP1487001KT</p></td><td> </td></tr><tr><td>Opal 570 Reagent Pack</td><td><p>FP1488001KT</p></td><td> </td></tr><tr><td>Opal 620 Reagent Pack</td><td><p>FP1495001KT</p></td><td> </td></tr><tr><td>Opal 690 Reagent Pack</td><td><p>FP1497001KT</p></td><td> </td></tr></tbody></table></div><p>Recommended dilution range for all reagents above: 1:750 - 1:3,000 </p><p><strong>Order the following components</strong><strong> from Leica Biosystems (LeicaBiosystems.com):</strong></p><div class="classification"><table align="center" border="1" cellpadding="1" cellspacing="1"><thead><tr><th><strong>Component</strong></th><th><strong>Cat. No.</strong></th></tr></thead><tbody><tr><td>Bond Research Detection System</td><td><a href="http://www.leicabiosystems.com/ihc-ish-fish/bond-ancillary-ihc-ish-reagents/details/product/bond-research-detection/">DS9455</a></td></tr><tr><td>BOND Open Containers 30 mL</td><td><a href="http://www.leicabiosystems.com/ihc-ish-fish/bond-ancillary-ihc-ish-reagents/consumables/details/product/bond-open-containers-30-ml/">Op309700</a></td></tr><tr><td>BOND Universal Covertiles 100 pack</td><td>S21.2001</td></tr><tr><td>BOND Epitope Retrieval Solution 1-1L (RTU)</td><td><a href="http://www.leicabiosystems.com/ihc-ish-fish/bond-ancillary-ihc-ish-reagents/reagents/details/product/bond-epitope-retrieval-solution-1/">AR9961</a></td></tr><tr><td>BOND Epitope Retrieval Solution 2-1L (RTU)</td><td><a href="http://www.leicabiosystems.com/ihc-ish-fish/bond-ancillary-ihc-ish-reagents/reagents/details/product/bond-epitope-retrieval-solution-2/">AR9640</a></td></tr><tr><td>BOND Dewax Solution – 1L (RTU)</td><td><a href="http://www.leicabiosystems.com/ihc-ish-fish/bond-ancillary-ihc-ish-reagents/reagents/details/product/bond-dewax-solution/">AR9222</a></td></tr><tr><td>BOND Wash Solution 10X Concentrate – 1L</td><td><a href="http://www.leicabiosystems.com/ihc-ish-fish/bond-ancillary-ihc-ish-reagents/reagents/details/product/bond-wash-solution-10x-concentrate/">AR9590</a></td></tr><tr><td>BOND Aspirating Probe Cleaning System</td><td><a href="http://www.leicabiosystems.com/ihc-ish-fish/bond-ancillary-ihc-ish-reagents/consumables/details/product/bond-aspirating-probe-cleaning-system/">CS9100</a></td></tr><tr><td>BOND Mixing Stations </td><td><a href="http://www.leicabiosystems.com/ihc-ish-fish/bond-ancillary-ihc-ish-reagents/consumables/details/product/bond-mixing-stations/">S21.1971</a></td></tr></tbody></table></div></div><p> </p></div><div class="shop-products"> <a href="https://acdbio.com/search/site/%252A%252A/cms/product/product-type/automated-assay-25-leica-system">Shop 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embedded_svc.inviteAPI.inviteButton.rejectInvite(); }; document.getElementById('rejectInvite').onclick = function() { embedded_svc.inviteAPI.inviteButton.rejectInvite(); }; // use this API call to reject invitations document.getElementById('acceptInvite').onclick = function() { embedded_svc.liveAgentAPI.startChat({ directToButtonRouting: { buttonId: "5733t000000cVk9" }, extraPrechatInfo: [], extraPrechatFormDetails: [] }); }; // use this API call to start chat from invitations document.addEventListener('keyup', function(event) { if (event.keyCode == 27) { embedded_svc.inviteAPI.inviteButton.rejectInvite(); }}) })(); </script>  <script type='text/javascript' src='https://service.force.com/embeddedservice/5.0/esw.min.js'></script> <script type='text/javascript'> var initESW = function(gslbBaseURL) { embedded_svc.settings.displayHelpButton = true; //Or false embedded_svc.settings.language = ''; //For example, enter 'en' or 'en-US' embedded_svc.settings.defaultMinimizedText = 'Chat now'; //(Defaults to Chat with an Expert) embedded_svc.settings.disabledMinimizedText = 'Leave a message'; //(Defaults to Agent Offline) embedded_svc.settings.autoOpenPostChat = true; //embedded_svc.settings.loadingText = ''; //(Defaults to Loading) //embedded_svc.settings.storageDomain = 'yourdomain.com'; //(Sets the domain for your deployment so that visitors can navigate subdomains during a chat session) // Settings for Chat embedded_svc.settings.directToButtonRouting = function (prechatFormData) { if (prechatFormData[4].value === "Technical Service") return "5733t000000XZAM"; if (prechatFormData[4].value === "Customer Care") return "5733t000000XZAH"; }; embedded_svc.settings.prepopulatedPrechatFields = { OmniURL__c: window.location.href, ChooseaDepartment__c: 'Technical Service' }; //Sets the auto-population of pre-chat form fields embedded_svc.settings.extraPrechatFormDetails = [{ "label":"Source Domain", "value":window.location.href, "transcriptFields":[ "Source_Domain__c" ], "displayToAgent":true }]; //embedded_svc.settings.fallbackRouting = []; //An array of button IDs, user IDs, or userId_buttonId embedded_svc.settings.offlineSupportMinimizedText = 'Leave a message'; //(Defaults to Contact Us) embedded_svc.settings.enabledFeatures = ['LiveAgent']; embedded_svc.settings.entryFeature = 'LiveAgent'; embedded_svc.init( 'https://biotechne.my.salesforce.com', 'https://biotechne.my.salesforce-sites.com/LiveAgent', gslbBaseURL, '00D500000006gkl', 'ACD_Chat_Automated', { baseLiveAgentContentURL: 'https://c.la1-c1-ia5.salesforceliveagent.com/content', deploymentId: '572380000004CqL', buttonId: '5733t000000cVk9', baseLiveAgentURL: 'https://d.la1-c1-ia5.salesforceliveagent.com/chat', eswLiveAgentDevName: 'EmbeddedServiceLiveAgent_Parent04I3t000000Y7zbEAC_175bb741b99', isOfflineSupportEnabled: true } ); }; if (!window.embedded_svc) { var s = document.createElement('script'); s.setAttribute('src', 'https://biotechne.my.salesforce.com/embeddedservice/5.0/esw.min.js'); s.onload = function() { initESW(null); }; document.body.appendChild(s); } else { initESW('https://service.force.com'); } </script> <script src="//rum-static.pingdom.net/pa-5c133f6e1872b50016000024.js" async></script> <script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"NRJS-dd6144c4de227d09eb4","applicationID":"1022125825","transactionName":"YFxbZkpUXBYEVkYNWVkWbEBRGlsLAVBKSkZfSQ==","queueTime":0,"applicationTime":326,"atts":"TBtYEAJOTxg=","errorBeacon":"bam.nr-data.net","agent":""}</script></body> </html>