Institute of Organic Chemistry and Biochemistry of the CAS

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is-for-desktop"> <img :src="image" :alt="imageAlt" v-if="image" /> </div> </a> </template> <template id="member-preview-template"> <div class="member-preview"> <div v-if="image" class="member-preview__image-container" :src="image"> <img class="member-preview__image" :src="image" /> </div> <div class="member-preview__text"> <div class="member-preview__name">${ name }</div> <div class="member-preview__position">${ position }</div> </div> <img v-if="showArrow" src="/icon/arrow-right.svg" alt="arrow" class="a-link__icon a-link__icon--no-martgin-right" /> </div> </template> <template id="open-position-preview-template"> <a :href="link" class="m-openPositionPreview"> <div class="m-openPositionPreview__content"> <div class="m-openPositionPreview__position">${ position }</div> <div class="m-openPositionPreview__name">${ name }</div> <div class="m-openPositionPreview__description">${ description }</div> </div> <div class="m-openPositionPreview__arrow"> <svg width="6" height="17" viewBox="0 0 6 17" fill="none" xmlns="http://www.w3.org/2000/svg"> <path fill-rule="evenodd" clip-rule="evenodd" d="M1.24042 0.209665L5.81669 8.14204L1.24042 16.0684H0.289063L4.86063 8.14204L0.289063 0.209665H1.24042Z" fill="#4A4A4A"/> <mask id="mask0" x="0" y="0" width="6" height="17"> <path fill-rule="evenodd" clip-rule="evenodd" d="M1.24042 0.209665L5.81669 8.14204L1.24042 16.0684H0.289063L4.86063 8.14204L0.289063 0.209665H1.24042Z" fill="white"/> </mask> <g mask="url(#mask0)"> <rect x="-9" y="-4" width="24" height="24" fill="#00205B"/> </g> </svg> </div> </a> </template> <template id="publication-preview-template"> <div class="m-publicationPreview"> <div class="m-publicationPreview__content"> <div class="m-publicationPreview__name" v-html="name"></div> <div class="m-publicationPreview__ArchiveImage-container is-for-mobile" v-if="photo" > <img :src="photo" alt class="m-publicationPreview__ArchiveImage" /> </div> <div class="m-publicationPreview__authors"> <template v-for="(author, count) in authors" :key="count"> <div v-if="!author.ldapId" :class="{ 'm-publicationPreview__author': true, 'm-publicationPreview__author--hidden': !showAllAuthors && count + 1 > sliceNumber, }" > ${ author.name } </div> <a v-else :href=" author.linkUrl" :target="author.linkTarget" :class="{ 'm-publicationPreview__author': true, 'm-publicationPreview__author--with-link': true, 'm-publicationPreview__author--highlighted': author.isGroupAuthor, 'm-publicationPreview__author--highlighted__blue': author.isGroupAuthor && author.groupColor == 'blue', 'm-publicationPreview__author--highlighted__green': author.isGroupAuthor && author.groupColor == 'green', 'm-publicationPreview__author--highlighted__orange': author.isGroupAuthor && author.groupColor == 'orange', 'm-publicationPreview__author--hidden': !showAllAuthors && count + 1 > sliceNumber, }" >${ author.name }</a > </template> <button v-if="!showAllAuthors && authors.length > sliceNumber" @click.prevent="showAllAuthors = true" class="m-publicationPreview__more-authors" > + ${ authors.length - sliceNumber } ${ authors.length - sliceNumber > 4 ? trans.mores : trans.more } </button> </div> <div class="m-publicationPreview__info" v-html="info"></div> <div v-if="link" class="m-publicationPreview__link"> <a :href="link" target="_blank" rel="noopener" class="a-link" style="margin-top: 24px" > Go to the publication <div class="m-publicationPreview__arrow"> <div class="a-link__icon"> <svg width="6" height="17" viewBox="0 0 6 17" fill="none" xmlns="http://www.w3.org/2000/svg"> <path fill-rule="evenodd" clip-rule="evenodd" d="M1.24042 0.209665L5.81669 8.14204L1.24042 16.0684H0.289063L4.86063 8.14204L0.289063 0.209665H1.24042Z" fill="#4A4A4A"/> <mask id="mask0" x="0" y="0" width="6" height="17"> <path fill-rule="evenodd" clip-rule="evenodd" d="M1.24042 0.209665L5.81669 8.14204L1.24042 16.0684H0.289063L4.86063 8.14204L0.289063 0.209665H1.24042Z" fill="white"/> </mask> <g mask="url(#mask0)"> <rect x="-9" y="-4" width="24" height="24" fill="#00205B"/> </g> </svg> </div> </div> </a> </div> </div> <div class="m-publicationPreview__ArchiveImage-container is-for-desktop" v-if="photo" > <img :src="photo" alt class="m-publicationPreview__ArchiveImage" /> </div> </div> </template> <template id="twitter-template"> <div class="m-twitter" v-if="profileName"> <div v-if="enabled" :key="container.width + 'x' + container.height"> <a class="twitter-timeline" :href="'https://twitter.com/' + profileName" :data-width="container.width" :data-height="container.height" :data-link-color="container.color" > <spinner :style="{ marginTop: '30px', marginBottom: '30px' }"></spinner> </a> </div> <div v-else> <div style="background-color: #dfe7f9; padding: 40px"> <p>${ cookieTextBlocker }</p> <a href="" data-cc="c-settings">${ cookieTextOpenSettings }</a> </div> </div> </div> </template><template id="unit-preview-template"> <a :href="link" class="m-unitPreview" target="_blank" rel="noopener"> <div class="m-unitPreview__content"> <div class="m-unitPreview__tags">${ tags }</div> <div class="m-unitPreview__name-by-leader">${ nameByLeader }</div> <div class="m-unitPreview__name">${ name }</div> <div class="m-unitPreview__keywords"> <div class="a-tag" v-for="(keyword, k) in keywords" :key="k">${ keyword }</div> </div> </div> <div class="m-unitPreview__arrow"> <svg width="6" height="17" viewBox="0 0 6 17" fill="none" xmlns="http://www.w3.org/2000/svg"> <path fill-rule="evenodd" clip-rule="evenodd" d="M1.24042 0.209665L5.81669 8.14204L1.24042 16.0684H0.289063L4.86063 8.14204L0.289063 0.209665H1.24042Z" fill="#4A4A4A"/> <mask id="mask0" x="0" y="0" width="6" height="17"> <path fill-rule="evenodd" clip-rule="evenodd" d="M1.24042 0.209665L5.81669 8.14204L1.24042 16.0684H0.289063L4.86063 8.14204L0.289063 0.209665H1.24042Z" fill="white"/> </mask> <g mask="url(#mask0)"> <rect x="-9" y="-4" width="24" height="24" fill="#00205B"/> </g> </svg> </div> </a> </template> <template id="vue-content-gallery-template"> <section class="o-vueContentGallery"> <figure class="o-vueContentGallery__figure"> <img :src="activeImage.path" :alt="activeImage.alt || ''" class="o-vueContentGallery__active" /> <figcaption class="o-vueContentGallery__caption" v-html="activeImage.caption" ></figcaption> </figure> <ul class="o-vueContentGallery__thumbnails"> <li> <img v-for="(image, i) in images" :src="image.path" :alt="image.alt" class="o-vueContentGallery__thumbnail" @click="selectImage(i)" @keypress.enter="selectImage(i)" :tabindex="i + 1" > </li> </ul> </section> </template> <template id="archive-filter-template"> <form class="o-archive-filter" ref="filterForm"> <div class="o-archive-filter__block" v-if="enableSearch"> <div class="o-archive-filter__input-wrapper"> <div class="o-archive-filter__input-image-wrapper"> <img class="o-archive-filter__input-loop" :src="'/images/search-loop.svg'" alt /> </div> <input class="o-archive-filter__input" type="text" placeholder="Search just anything…" v-model="searchValue" @keyup="onChange" name="search" /> </div> </div> <div class="o-archive-filter__block" v-for="item in fields"> <div class="o-archive-filter__header" @click="item.opened = !item.opened"> <div class="o-archive-filter__label">${ item.label }</div> <div class="o-archive-filter__button">+</div> </div> <div class="o-archive-filter__content" v-show="item.opened"> <div class="o-archive-filter__tags" v-if="item.type === 'tags'"> <div class="o-archive-filter__tag" v-for="tag in item.tags">  ${ tag.text } </div> </div> <div v-if="item.type === 'search'"> <vue-multiselect v-model="item.model" :options="getOptions(item)" :multiple="true" :close-on-select="false" :clear-on-select="false" label="apiLabel" track-by="apiId" @search-change="asyncFind" :internal-search="false" open-direction="bottom" :id="item.key" @select="onChange" @remove="onChange" select-label="✓" deselect-label="×" selected-label="✓" placeholder="Select option" > <span slot="noOptions">List is empty.</span> <span slot="noResult">List is empty.</span> </vue-multiselect> </div> <div class="o-archive-filter__rows" v-if="item.type === 'checkbox'"> <div class="o-archive-filter__row" v-for="checkbox in item.choices"> <label class="o-archive-filter__row-label"> <input type="checkbox" class="o-archive-filter__control" :value="checkbox.value" @change="onChange" v-model="item.model" /> <span class="o-archive-filter__checkmark"></span> ${ checkbox.label } </label> </div> </div> <div class="o-archive-filter__rows" v-if="item.type === 'radio'"> <div class="o-archive-filter__row" v-for="radio in item.choices"> <label class="o-archive-filter__row-label"> <input type="radio" class="o-archive-filter__control" :value="radio.value" @change="onChange" :selected="radio.selected" v-model="item.model" /> <span class="o-archive-filter__checkmark o-archive-filter__checkmark--rounded"></span> ${ radio.label } </label> </div> </div> <div class="o-archive-filter__radios" v-if="item.type === 'radioWithCheckboxes'"> <div class="o-archive-filter__row" v-for="radio in item.choices"> <label class="o-archive-filter__row-label"> <input type="radio" class="o-archive-filter__control" :value="radio.value" @change="onChange" v-model="item.model" /> <span class="o-archive-filter__checkmark o-archive-filter__checkmark--rounded"></span> ${ radio.label } </label> <div v-if="item.model == radio.value" class="o-archive-filter__subchoices"> <div class="o-archive-filter__row" v-for="checkbox in radio.choices"> <label class="o-archive-filter__row-label"> <input type="checkbox" class="o-archive-filter__control" :value="checkbox.value" @change="onChange" v-model="item.checkboxesModel" :disabled="item.model !== radio.value" /> <span class="o-archive-filter__checkmark"></span> ${ checkbox.label } </label> </div> </div> </div> </div> </div> </div> <a v-for="(link, l) in links" :class="blockClassName(link)" :key="l" :href="link.link"> <div class="o-archive-filter__header"> <div class="o-archive-filter__label">${ link.label }</div> </div> </a> </form> </template> <template id="archive-template"> <div class="o-archive"> <archive-filter :enable-search="config.search" :fields="config.filter" :links="config.links" :default-items="config.items" @change="updateList" @init="updateList" ></archive-filter> <div class="o-archive-positions"> <div class="o-archive-positions__item o-archive-positions__item--header" v-if="config.heading" > <div class="o-archive__heading">${ config.heading }</div> <a class="a-link" :href="config.backLink.link.url" v-if="config.backLink"> <img :src="'/icon/arrow-right.svg'" class="a-link__icon-left a-link__icon-left--arrow" alt /> ${ config.backLink.label } </a> </div> <div v-if="items && items.length > 0"> <open-position-preview v-if="type === 'open-position'" v-for="(item, i) in items" :key="i" class="o-archive-positions__item" :description="item.topic" :name="item.title" :position="item.type" :link="item.link" ></open-position-preview> <event-preview-big v-if="type === 'event'" v-for="(item, i) in items" :key="i" class="o-archive-positions__item" :image="item.image" :link="item.link" :title="item.title" :location="item.location" :label="item.labels.join(' | ')" :date="item.date" :text="item.text" ></event-preview-big> <publication-preview v-if="type === 'publication'" v-for="(item, i) in items" :key="i" :name="item.name" :info="item.info" :photo="item.photo" :link="item.link" :external="item.external" :authors="item.authors" class="o-archive-positions__item" :trans="trans" ></publication-preview> <article-preview v-if="type === 'article'" v-for="(item, i) in items" :key="i" :image="item.image" :title="item.title" :date="item.published" :text="item.text" :href="item.link" class="o-archive-positions__item" ></article-preview> <unit-preview v-if="type === 'unit'" v-for="(item, i) in items" :key="i" class="o-archive-positions__item" :name="item.name" :name-by-leader="item.nameByLeader" :keywords="item.keywords" :tags="item.tags.join(' | ')" :link="item.link" ></unit-preview> <instrument-category-preview v-if="type === 'instrumentCategory'" v-for="(item, i) in items" :key="i" class="o-archive-positions__item o-archive-positions__item--condensed" :name="item.label" :href="item.link" ></instrument-category-preview> <div v-if="type === 'instrument'"> <div v-for="(item, i) in items" :key="i"> <h2 class="o-archive-instruments__subcategory" v-if="item.category">${ item.category }</h2> <instrument-preview v-for="(instrument, j) in item.items" :key="j" class="o-archive-positions__item" :name="instrument.name" :description="instrument.description" :image="instrument.image" :image-alt="instrument.name" :link="instrument.link" ></instrument-preview> </div> </div> </div> <div v-else> <div v-if="isMounted && !isLoadingNextPage" style="padding: 30px 0 30px 40px" >${ noResultsMessage }</div> </div> <div v-if="!disableNextPageLoading" ref="nextPage"> <spinner style="margin: 30px auto" v-if="isLoadingNextPage" /> </div> </div> </div> </template><template id="directory-template"> <div :class="{'o-directory__search-container' : true, 'o-directory__search-container--embed' : embed}" > <div class="o-directory__search"> <div class="o-directory__input-wrapper"> <div class="o-directory__input-image-wrapper"> <img class="o-directory__input-loop" src="/images/search-loop.svg" /> </div> <input @keyup="onChange" class="o-directory__input" type="text" :placeholder="placeholder" v-model="search" /> </div> </div> <div class="o-directory__filter" v-if="expanded"> <span :class="itemClass(letter.letter)" @click="changeLetter(letter)" v-for="letter in filterLetters()" :key="letter.letter" >${ letter.letter }</span> </div> <div class="o-directory__items" v-if="isSearchingSomething">  <div v-if="expanded && filter.letter" class="o-directory__title">${filter.letter.letter}</div> <div v-if="!results.length && !isLoading">${ noResult }</div>  <div @click="redirectToLink(row.link)" class="o-directory__item" v-for="row in results" :key="row.index" > <member-preview :name="row.surname + ' ' + row.name" :position="row.position" :image="showMemberImage ? row.image : null" :show-arrow="true" /> </div> <spinner style="margin: 30px auto" v-if="isLoading" /> </div> </div> </template><template id="member-select-template"> <div class="member-select"> <vue-multiselect v-model="value" :options="options" @select="selectOption" :show-labels="false" placeholder="Search people…" label="fullName" track-by="id" @search-change="asyncFind" > <template slot="noResult">Your search matches no results.</template> <template slot="noOptions">Your search matches no results.</template> <template slot="option" slot-scope="props"> <member-preview :name="props.option.fullName" :position="props.option.position" :image="props.option.photo" :link="props.option.link" ></member-preview> </template> <template slot="singleLabel" slot-scope="props">${ props.option.title }</template> </vue-multiselect> </div> </template> <template id="search-template"> <div class="o-search-global"> <header-main-search @change="updateList" :back-link="config.backLink"></header-main-search> <search-results ref="results" :results="results" @load-next="loadNext" :translations="translations" ></search-results> </div> </template><template id="search-results-template"> <div class="o-search-results"> <ul class="o-search-results__tabs"> <li :class="{'o-search-results__tab': true, 'o-search-results__tab--active': selectedCategory == null }" @click="selectCategory(null)" > All <span v-if="allItemsLength" class="o-search-results__tab--count"> <span>(${ allItemsLength })</span> </span> <span v-if="somethingLoading" class="o-search-results__tab--loader"> <spinner size="25px"></spinner> </span> </li> <li v-for="(categoryResults, categoryKey) in results" v-bind:key="'tabs:' + categoryKey" :class="{'o-search-results__tab': true, 'o-search-results__tab--active': selectedCategory == categoryKey }" @click="selectCategory(categoryKey)" > ${categoryResults.label} <span v-if="categoryResults.total" class="o-search-results__tab--count" > <span>(${ categoryResults.total })</span> </span> <span v-if="categoryResults.loading" class="o-search-results__tab--loader"> <spinner size="25px"></spinner> </span> </li> </ul> <div v-for="(categoryResults, categoryKey) in results" v-bind:key="'result:' + categoryKey"> <div v-if="results[categoryKey].rows.length && (selectedCategory == categoryKey || !selectedCategory)" >  <label class="o-search-results__label" v-if="!selectedCategory" @click="selectCategory(categoryKey)" >${ results[categoryKey].label }</label> <div class="o-search-results__results"> <search-item v-for="row in ( selectedCategory ? results[categoryKey].rows : results[categoryKey].rows.slice(0, 3))" :key="row.id" :main="itemMainValue(row, categoryKey)" :second="itemSecondValue(row, categoryKey)" :link="row.link" type="big" ></search-item> </div> <div v-if="selectedCategory && !results[categoryKey].isLast" ref="nextPage"> <spinner v-if="results[categoryKey].isLoadingNext" size="25px"></spinner> </div> <div @click="selectCategory(categoryKey)" class="o-search-results__results--more" v-if="!selectedCategory && results[categoryKey].total > 3" >${ translations.showNext + " (" + (results[categoryKey].total - 3) + ")" }</div> </div> </div> </div> </template><template id="vue-content-embed-youtube-template"> <div v-if="enabled" > <div class="o-vueContentEmbedYoutube__wrapper"> <div class="o-vueContentEmbedYoutube"> <iframe class="a-embedYoutube__item" :src="src"></iframe> </div> </div> </div> <div v-else> <div style="background-color: #dfe7f9; padding: 40px"> <p>${ cookieTextBlocker }</p> <a href="" data-cc="c-settings">${ cookieTextOpenSettings }</a> </div> </div> </template><template id="vue-content-embed-facebook-template"> <div v-if="enabled" > <div class="fb-page" :data-href="href" data-tabs="timeline" data-width="500" data-height="" data-small-header="false" data-adapt-container-width="true" data-hide-cover="false" data-show-facepile="false"> <blockquote :cite="href" class="fb-xfbml-parse-ignore"> <a :href="href"></a> </blockquote> </div> </div> <div v-else> <div style="background-color: #dfe7f9; padding: 40px"> <p>${ cookieTextBlocker }</p> <a href="" data-cc="c-settings">${ cookieTextOpenSettings }</a> </div> </div> </template><template id="vue-content-embed-spotify-template"> <div v-if="enabled" > <div class="o-vueContentEmbedSpotify__wrapper"> <div class="o-vueContentEmbedSpotify"> <iframe width="100%" height="152" :src="src" frameborder="0" frameBorder="0" allowfullscreen="" allow="autoplay; clipboard-write; encrypted-media; fullscreen; picture-in-picture" loading="lazy"></iframe> </div> </div> </div> <div v-else> <div style="background-color: #dfe7f9; padding: 40px"> <p>${ cookieTextBlocker }</p> <a href="" data-cc="c-settings">${ cookieTextOpenSettings }</a> </div> </div> </template> <div id="vue"> <header class="o-header-main-homepage" > <div class="o-header-main-homepage__main-section"> <div class="a-container"> <div class="o-header-main-homepage__navigation-wrapper"> <div class="o-header-main-homepage__logo"> <a href="/en"> <div style="color: white; height: 60px"> <svg height="100%" width="100%" viewBox="75.254 116.803 190.312 88.834" xmlns="http://www.w3.org/2000/svg"> <path fill="currentColor" d="M 114.159 116.773 L 75.329 138.963 L 75.329 183.343 L 114.159 205.533 L 152.999 183.343 L 152.999 138.963 L 114.159 116.773 L 114.159 116.773 Z M 91.969 177.253 C 89.209 177.253 86.969 175.013 86.969 172.243 C 86.969 169.473 89.209 167.233 91.969 167.233 C 94.729 167.233 96.979 169.483 96.979 172.243 C 96.979 175.003 94.739 177.253 91.969 177.253 Z M 91.969 166.153 C 89.209 166.153 86.969 163.913 86.969 161.153 C 86.969 158.393 89.209 156.143 91.969 156.143 C 94.729 156.143 96.979 158.383 96.979 161.153 C 96.979 163.923 94.739 166.153 91.969 166.153 Z M 91.969 155.063 C 89.209 155.063 86.969 152.823 86.969 150.053 C 86.969 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href="/en/list-of-publications?authorIds=1312102" class="m-publicationPreview__author m-publicationPreview__author--with-link "> N. Kuprikova </a> <a href="/en/list-of-publications?authorIds=1381" class="m-publicationPreview__author m-publicationPreview__author--with-link "> M. Ondruš </a> <a href="/en/list-of-publications?authorIds=11" class="m-publicationPreview__author m-publicationPreview__author--with-link "> L. Bednárová </a> <a href="/en/list-of-publications?authorIds=149" class="m-publicationPreview__author m-publicationPreview__author--with-link "> T. Kraus </a> <a href="/en/list-of-publications?authorIds=366" class="m-publicationPreview__author m-publicationPreview__author--with-link "> L. Poštová Slavětínská </a> <a href="/en/list-of-publications?authorIds=4417" class="m-publicationPreview__author m-publicationPreview__author--with-link "> V. Sýkorová </a> <a href="/en/list-of-publications?authorIds=89" class="m-publicationPreview__author m-publicationPreview__author--with-link "> M. Hocek </a> </div> <div class="m-publicationPreview__info"> <i>Nucleic Acids Research</i> <strong>53</strong> (5): gkaf155 (2025) </div> <div class="m-publicationPreview__text"> We designed and synthesized a set of four 2′-deoxyribonucleoside 5′-<i>O</i>-triphosphates (dNTPs) bearing cationic substituents (protonated amino, methylamino, dimethylamino and trimethylammonium groups) attached to position 5 of pyrimidines or position 7 of 7-deazapurines through hex-1-ynyl or propargyl linker. These cationic dNTPs were studied as substrates in enzymatic synthesis of modified and hypermodified DNA using KOD XL DNA polymerase. In primer extension (PEX), we successfully obtained DNA containing one, two, three, or (all) four modified nucleotides, each bearing a different cationic modification. The cationic dNTPs were somewhat worse substrates compared to previously studied dNTPs bearing hydrophobic or anionic modifications, but the polymerase was still able to synthesize sequences up to 73 modified nucleotides. We also successfully combined one cationic modification with one anionic and two hydrophobic modifications in PEX. In polymerase chain reaction (PCR), we observed… </div> <div class="m-publicationPreview__link"> <a class="a-link" href="http://dx.doi.org/10.1093/nar/gkaf155" target='_blank' > Go to the publication <img src="/icon/arrow-right.svg" class="a-link__icon " alt="arrow"> </a> </div> </div> </div> </div> </div> <div class="o-publications__items "> <div class="o-publications__item "> <div class="m-publicationPreview "> <div class="m-publicationPreview__content"> <div> <div class="m-publicationPreview__title"> Computational metabolomics reveals overlooked chemodiversity of alkaloid scaffolds in <i>Piper fimbriulatum</i> </div> <div class="m-publicationPreview__authors"> <a href="/en/list-of-publications?authorIds=1316042" class="m-publicationPreview__author m-publicationPreview__author--with-link "> T. Damiani </a> <a href="/en/list-of-publications?authorIds=414374" class="m-publicationPreview__author m-publicationPreview__author--with-link "> J. 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Pluskal </a> <button class="m-publicationPreview__more-authors"> + 1 more </button> </div> <div class="m-publicationPreview__info"> <i>The Plant Journal</i> <strong>124</strong> (5): e70086 (2025) </div> <div class="m-publicationPreview__link"> <a class="a-link" href="http://dx.doi.org/10.1111/tpj.70086" target='_blank' > Go to the publication <img src="/icon/arrow-right.svg" class="a-link__icon " alt="arrow"> </a> </div> </div> </div> </div> </div> <div class="o-publications__item "> <div class="m-publicationPreview "> <div class="m-publicationPreview__content"> <div> <div class="m-publicationPreview__title"> Liquid chromatography–inductively coupled plasma mass spectrometry analysis of peptides labelled with ClickZip mass tags </div> <div class="m-publicationPreview__authors"> <a href="/en/list-of-publications?authorIds=1413104" class="m-publicationPreview__author m-publicationPreview__author--with-link "> A. 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