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class="StudyOverview_iconBackground__1EoT_"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" width="20px" height="20px" fill="white" class="bi bi-chat-square-quote-fill"><path d="M0 2a2 2 0 0 1 2-2h12a2 2 0 0 1 2 2v8a2 2 0 0 1-2 2h-2.5a1 1 0 0 0-.8.4l-1.9 2.533a1 1 0 0 1-1.6 0L5.3 12.4a1 1 0 0 0-.8-.4H2a2 2 0 0 1-2-2zm7.194 2.766a1.7 1.7 0 0 0-.227-.272 1.5 1.5 0 0 0-.469-.324l-.008-.004A1.8 1.8 0 0 0 5.734 4C4.776 4 4 4.746 4 5.667c0 .92.776 1.666 1.734 1.666.343 0 .662-.095.931-.26-.137.389-.39.804-.81 1.22a.405.405 0 0 0 .011.59c.173.16.447.155.614-.01 1.334-1.329 1.37-2.758.941-3.706a2.5 2.5 0 0 0-.227-.4zM11 7.073c-.136.389-.39.804-.81 1.22a.405.405 0 0 0 .012.59c.172.16.446.155.613-.01 1.334-1.329 1.37-2.758.942-3.706a2.5 2.5 0 0 0-.228-.4 1.7 1.7 0 0 0-.227-.273 1.5 1.5 0 0 0-.469-.324l-.008-.004A1.8 1.8 0 0 0 10.07 4c-.957 0-1.734.746-1.734 1.667 0 .92.777 1.666 1.734 1.666.343 0 .662-.095.931-.26z"></path></svg></div><div><div class="StudyOverview_bold__AxWJY">Citation<a tabindex="0"><svg width="15" height="15" viewBox="0 0 15 15" fill="none" xmlns="http://www.w3.org/2000/svg"><circle cx="7.5" cy="7.5" r="7.5" fill="black"></circle><path d="M6.8437 7.772C6.85303 7.744 6.86236 7.674 6.8717 7.562C6.89036 7.44067 6.8997 7.36133 6.8997 7.324C6.8997 7.25867 6.8857 7.198 6.8577 7.142C6.8297 7.07667 6.77836 7.044 6.7037 7.044C6.61036 7.044 6.48436 7.10933 6.3257 7.24C6.17636 7.36133 6.04103 7.492 5.9197 7.632C5.8077 7.76267 5.74236 7.842 5.7237 7.87C5.67703 7.87 5.63503 7.81867 5.5977 7.716C5.56036 7.61333 5.5417 7.54333 5.5417 7.506C5.5977 7.394 5.70503 7.24933 5.8637 7.072C6.02236 6.89467 6.20436 6.71267 6.4097 6.526C6.61503 6.33933 6.82503 6.18533 7.0397 6.064C7.2637 5.93333 7.46903 5.868 7.6557 5.868C7.92636 5.868 8.1457 5.952 8.3137 6.12C8.49103 6.27867 8.5797 6.51667 8.5797 6.834C8.5797 6.92733 8.56103 7.06733 8.5237 7.254C8.4957 7.44067 8.47236 7.57133 8.4537 7.646L7.9497 10.194C7.94036 10.222 7.92636 10.2967 7.9077 10.418C7.89836 10.53 7.8937 10.6047 7.8937 10.642C7.8937 10.7073 7.9077 10.7727 7.9357 10.838C7.9637 10.9033 8.01036 10.936 8.0757 10.936C8.17836 10.936 8.30436 10.8707 8.4537 10.74C8.60303 10.6093 8.73836 10.4787 8.8597 10.348C8.98103 10.208 9.04636 10.124 9.0557 10.096C9.10236 10.096 9.14436 10.1473 9.1817 10.25C9.21903 10.3527 9.2377 10.4273 9.2377 10.474C9.1817 10.586 9.0697 10.7307 8.9017 10.908C8.74303 11.0853 8.55636 11.2673 8.3417 11.454C8.12703 11.6407 7.9077 11.7993 7.6837 11.93C7.4597 12.0513 7.25436 12.112 7.0677 12.112C6.8437 12.112 6.64303 12.0373 6.4657 11.888C6.2977 11.7293 6.2137 11.4773 6.2137 11.132C6.2137 11.0293 6.2277 10.8847 6.2557 10.698C6.29303 10.502 6.31636 10.376 6.3257 10.32L6.8437 7.772ZM8.2997 2.606C8.53303 2.606 8.72436 2.69 8.8737 2.858C9.02303 3.01667 9.0977 3.21733 9.0977 3.46C9.0977 3.75867 8.99036 4.02933 8.7757 4.272C8.56103 4.50533 8.30903 4.622 8.0197 4.622C7.78636 4.622 7.59503 4.538 7.4457 4.37C7.3057 4.19267 7.2357 3.98733 7.2357 3.754C7.2357 3.45533 7.33836 3.18933 7.5437 2.956C7.75836 2.72267 8.01036 2.606 8.2997 2.606Z" fill="white"></path></svg></a></div><div>Magee, John (2025). Analysis of Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis Cohort Using Advanced MRI to Characterize and Predict CF Liver Disease (PUSH-MRE) (Version 1) [Dataset] NIDDK Central Repository. </div></div></div><div class="StudyOverview_headerItem__s6tLL"><div class="StudyOverview_iconBackground__1EoT_"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" width="20px" height="20px" fill="white" class="bi bi-file-text-fill"><path d="M12 0H4a2 2 0 0 0-2 2v12a2 2 0 0 0 2 2h8a2 2 0 0 0 2-2V2a2 2 0 0 0-2-2M5 4h6a.5.5 0 0 1 0 1H5a.5.5 0 0 1 0-1m-.5 2.5A.5.5 0 0 1 5 6h6a.5.5 0 0 1 0 1H5a.5.5 0 0 1-.5-.5M5 8h6a.5.5 0 0 1 0 1H5a.5.5 0 0 1 0-1m0 2h3a.5.5 0 0 1 0 1H5a.5.5 0 0 1 0-1"></path></svg></div><div><div class="StudyOverview_bold__AxWJY">Data Availability Statement<a tabindex="0"><svg width="15" height="15" viewBox="0 0 15 15" fill="none" xmlns="http://www.w3.org/2000/svg"><circle cx="7.5" cy="7.5" r="7.5" fill="black"></circle><path d="M6.8437 7.772C6.85303 7.744 6.86236 7.674 6.8717 7.562C6.89036 7.44067 6.8997 7.36133 6.8997 7.324C6.8997 7.25867 6.8857 7.198 6.8577 7.142C6.8297 7.07667 6.77836 7.044 6.7037 7.044C6.61036 7.044 6.48436 7.10933 6.3257 7.24C6.17636 7.36133 6.04103 7.492 5.9197 7.632C5.8077 7.76267 5.74236 7.842 5.7237 7.87C5.67703 7.87 5.63503 7.81867 5.5977 7.716C5.56036 7.61333 5.5417 7.54333 5.5417 7.506C5.5977 7.394 5.70503 7.24933 5.8637 7.072C6.02236 6.89467 6.20436 6.71267 6.4097 6.526C6.61503 6.33933 6.82503 6.18533 7.0397 6.064C7.2637 5.93333 7.46903 5.868 7.6557 5.868C7.92636 5.868 8.1457 5.952 8.3137 6.12C8.49103 6.27867 8.5797 6.51667 8.5797 6.834C8.5797 6.92733 8.56103 7.06733 8.5237 7.254C8.4957 7.44067 8.47236 7.57133 8.4537 7.646L7.9497 10.194C7.94036 10.222 7.92636 10.2967 7.9077 10.418C7.89836 10.53 7.8937 10.6047 7.8937 10.642C7.8937 10.7073 7.9077 10.7727 7.9357 10.838C7.9637 10.9033 8.01036 10.936 8.0757 10.936C8.17836 10.936 8.30436 10.8707 8.4537 10.74C8.60303 10.6093 8.73836 10.4787 8.8597 10.348C8.98103 10.208 9.04636 10.124 9.0557 10.096C9.10236 10.096 9.14436 10.1473 9.1817 10.25C9.21903 10.3527 9.2377 10.4273 9.2377 10.474C9.1817 10.586 9.0697 10.7307 8.9017 10.908C8.74303 11.0853 8.55636 11.2673 8.3417 11.454C8.12703 11.6407 7.9077 11.7993 7.6837 11.93C7.4597 12.0513 7.25436 12.112 7.0677 12.112C6.8437 12.112 6.64303 12.0373 6.4657 11.888C6.2977 11.7293 6.2137 11.4773 6.2137 11.132C6.2137 11.0293 6.2277 10.8847 6.2557 10.698C6.29303 10.502 6.31636 10.376 6.3257 10.32L6.8437 7.772ZM8.2997 2.606C8.53303 2.606 8.72436 2.69 8.8737 2.858C9.02303 3.01667 9.0977 3.21733 9.0977 3.46C9.0977 3.75867 8.99036 4.02933 8.7757 4.272C8.56103 4.50533 8.30903 4.622 8.0197 4.622C7.78636 4.622 7.59503 4.538 7.4457 4.37C7.3057 4.19267 7.2357 3.98733 7.2357 3.754C7.2357 3.45533 7.33836 3.18933 7.5437 2.956C7.75836 2.72267 8.01036 2.606 8.2997 2.606Z" fill="white"></path></svg></a></div><div>Data from the Analysis of Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis Cohort Using Advanced MRI to Characterize and Predict CF Liver Disease (PUSH-MRE) [(Version 1) ] reported here are available for request at the NIDDK Central Repository (NIDDK-CR) website, Resources for Research (R4R), https://repository.niddk.nih.gov/.</div></div></div><div class="StudyOverview_headerItem__s6tLL"><div class="StudyOverview_iconBackground__1EoT_"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" width="20px" height="20px" fill="white" class="bi bi-file-earmark-check-fill"><path d="M9.293 0H4a2 2 0 0 0-2 2v12a2 2 0 0 0 2 2h8a2 2 0 0 0 2-2V4.707A1 1 0 0 0 13.707 4L10 .293A1 1 0 0 0 9.293 0M9.5 3.5v-2l3 3h-2a1 1 0 0 1-1-1m1.354 4.354-3 3a.5.5 0 0 1-.708 0l-1.5-1.5a.5.5 0 1 1 .708-.708L7.5 9.793l2.646-2.647a.5.5 0 0 1 .708.708"></path></svg></div><div><div class="StudyOverview_bold__AxWJY">Acknowledgement Statement<a tabindex="0"><svg width="15" height="15" viewBox="0 0 15 15" fill="none" xmlns="http://www.w3.org/2000/svg"><circle cx="7.5" cy="7.5" r="7.5" fill="black"></circle><path d="M6.8437 7.772C6.85303 7.744 6.86236 7.674 6.8717 7.562C6.89036 7.44067 6.8997 7.36133 6.8997 7.324C6.8997 7.25867 6.8857 7.198 6.8577 7.142C6.8297 7.07667 6.77836 7.044 6.7037 7.044C6.61036 7.044 6.48436 7.10933 6.3257 7.24C6.17636 7.36133 6.04103 7.492 5.9197 7.632C5.8077 7.76267 5.74236 7.842 5.7237 7.87C5.67703 7.87 5.63503 7.81867 5.5977 7.716C5.56036 7.61333 5.5417 7.54333 5.5417 7.506C5.5977 7.394 5.70503 7.24933 5.8637 7.072C6.02236 6.89467 6.20436 6.71267 6.4097 6.526C6.61503 6.33933 6.82503 6.18533 7.0397 6.064C7.2637 5.93333 7.46903 5.868 7.6557 5.868C7.92636 5.868 8.1457 5.952 8.3137 6.12C8.49103 6.27867 8.5797 6.51667 8.5797 6.834C8.5797 6.92733 8.56103 7.06733 8.5237 7.254C8.4957 7.44067 8.47236 7.57133 8.4537 7.646L7.9497 10.194C7.94036 10.222 7.92636 10.2967 7.9077 10.418C7.89836 10.53 7.8937 10.6047 7.8937 10.642C7.8937 10.7073 7.9077 10.7727 7.9357 10.838C7.9637 10.9033 8.01036 10.936 8.0757 10.936C8.17836 10.936 8.30436 10.8707 8.4537 10.74C8.60303 10.6093 8.73836 10.4787 8.8597 10.348C8.98103 10.208 9.04636 10.124 9.0557 10.096C9.10236 10.096 9.14436 10.1473 9.1817 10.25C9.21903 10.3527 9.2377 10.4273 9.2377 10.474C9.1817 10.586 9.0697 10.7307 8.9017 10.908C8.74303 11.0853 8.55636 11.2673 8.3417 11.454C8.12703 11.6407 7.9077 11.7993 7.6837 11.93C7.4597 12.0513 7.25436 12.112 7.0677 12.112C6.8437 12.112 6.64303 12.0373 6.4657 11.888C6.2977 11.7293 6.2137 11.4773 6.2137 11.132C6.2137 11.0293 6.2277 10.8847 6.2557 10.698C6.29303 10.502 6.31636 10.376 6.3257 10.32L6.8437 7.772ZM8.2997 2.606C8.53303 2.606 8.72436 2.69 8.8737 2.858C9.02303 3.01667 9.0977 3.21733 9.0977 3.46C9.0977 3.75867 8.99036 4.02933 8.7757 4.272C8.56103 4.50533 8.30903 4.622 8.0197 4.622C7.78636 4.622 7.59503 4.538 7.4457 4.37C7.3057 4.19267 7.2357 3.98733 7.2357 3.754C7.2357 3.45533 7.33836 3.18933 7.5437 2.956C7.75836 2.72267 8.01036 2.606 8.2997 2.606Z" fill="white"></path></svg></a></div><div>The PUSH-MRE study was conducted by the study investigators and supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The resources from the PUSH-MRE study reported here were supplied by NIDDK Central Repository (NIDDK-CR) and are available for request at https://repository.niddk.nih.gov. This manuscript was not prepared under the auspices of the PUSH-MRE study and does not necessarily reflect the opinions or views of the PUSH-MRE study, NIDDK-CR, or NIDDK."</div></div></div><div class="StudyOverview_headerItem__s6tLL"><div class="StudyOverview_iconBackground__1EoT_"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" width="20px" height="20px" fill="white" class="bi bi-tag-fill"><path d="M2 1a1 1 0 0 0-1 1v4.586a1 1 0 0 0 .293.707l7 7a1 1 0 0 0 1.414 0l4.586-4.586a1 1 0 0 0 0-1.414l-7-7A1 1 0 0 0 6.586 1zm4 3.5a1.5 1.5 0 1 1-3 0 1.5 1.5 0 0 1 3 0"></path></svg></div><div><div class="StudyOverview_bold__AxWJY">Data Package Version</div><div>Version 1 (Updated on: Jan 09, 2025)</div></div></div></div><div class="StudyOverview_topRightContainer__8bxiG col-lg-3"><div class="StudyOverview_graybox__SoeAQ StudyOverview_pubBox__tK9w9"><div class="StudyOverview_bold__AxWJY">Resource Availability</div><div><ul><li>Data Available for Request</li><li>Specimens Not Available</li></ul></div></div><div class="StudyOverview_graybox__SoeAQ StudyOverview_pubBox__tK9w9"><div class="StudyOverview_bold__AxWJY">Publications</div><div>Explore publications resulting from the use of study resources</div><a href="/search/publications?&facets=%5B%7B%22name%22:%22study_acronym_array%22,%22facets%22:%5B%22PUSH-MRE%22%5D%7D%5D">View publications (0)</a></div></div></div><div class="StudyOverview_Row___uK4C row"><div class="StudyOverview_Col__Ho7wa col"><div tabindex="0" id="0" aria-label="Study Overview collapsable section" class=" StudyOverview_accordion__xGdM_ undefined accordion"><div class="undefined Accordion_dataItem__pZkIy accordion-item"><h2 class="undefined Accordion_dataHeader__8IWP_ accordion-header"><button type="button" aria-expanded="true" class="accordion-button"><svg width="18" height="10" viewBox="0 0 22 10" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M1 1.49609L10.8765 8.63072L21 1.49609" stroke="currentColor" stroke-width="2"></path></svg>Study Overview</button></h2><div class="accordion-collapse collapse show"><div class="undefined Accordion_dataBody__qQzXM accordion-body"><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">General Description</div><div><p>The Analysis of Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis Cohort Using Advanced MRI to Characterize and Predict CF Liver Disease (PUSH-MRE) study was a prospective cross sectional ancillary study of children and adolescents with cystic fibrosis enrolled in the Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis Liver Disease (CFLD PUSH) study. PUSH-MRE sought to determine the feasibility of MRI and magnetic resonance elastography (MRE) to predict the development of advanced liver disease in children and adolescents with CF. Participants were a subset to those enrolled in the CFLD PUSH study, at 8 of the 11 centers that had research MRE capability. This study is an ancillary study to the CFLD PUSH study. If requesting access to the PUSH-MRE data, it is recommended to also request access to the CFLD PUSH data to obtain comprehensive information collected on study participants.</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Objectives</div><div><p>The primary objectives were to:</p> <ul> <li>Determine the feasibility of unsedated MRI/MRE assessments of liver stiffness and hepatic lipid content in children and adolescents with CF</li> <li>Determine hepatic lipid content using HepaFat and liver stiffness by MRE compared to ultrasound data and vibration controlled transient elastography in the same cohort</li> </ul> <p>The secondary objectives were to:</p> <ul> <li>Develop an imaging core to centralize MR imaging data</li> <li>Determine the correlation between local MRE and MRI interpretation and central interpretation</li> <li>Assess if MRI imaging data improves the discrimination of those participants at risk for advanced CF liver disease (as determined by ultrasound nodular pattern)</li> </ul></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Outcome Measure</div><div><p>Outcome measures included changes over time in liver stiffness and lipid content using MRE. Analysis of variance (ANOVA) was used to compare the distribution of liver stiffness (in kPa) and lipid content measures between all groups defined by the CFLD PUSH study grayscale ultrasound results over time.</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Eligibility Criteria</div><div><p>Inclusion criteria:</p> <ul> <li>Participation in the CFLD PUSH study which enrolled children aged 3 through 12 years of age diagnosed with cystic fibrosis and pancreatic insufficiency</li> <li>At a center with MRI/MRE capability</li> <li>Able to perform unsedated MRI for 10-20 minutes</li> <li>Signed informed consent and if appropriate assent</li> </ul> <p>Exclusion criteria:</p> <ul> <li>Initial exclusion criteria for the CFLD PUSH study such as known cirrhosis prior to screening, presence of Burkholderia cepacian, short bowel syndrome, and presence of other serious disease preventing participation</li> <li>Inability to comply with longitudinal follow-up of the CFLD PUSH study</li> <li>Contraindication to MRI</li> </ul></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Outcome</div><div><p>There were 93 participants (51 females [54.8%]; mean 15.6 years [range 8.1–21.7 years]) that underwent MRI, in which MR elastography was feasible for 87 participants (93.5%), and 58 participants had an ultrasound within 1 year of MRI. In these participants, a nodular liver had significantly higher stiffness (p < 0.01) than normal or homogeneous hyperechoic livers. Participants with a homogeneous hyperechoic liver had a higher fat fraction (p < 0.005) than others.</p></div></div></div></div></div></div></div></div><div class="StudyOverview_Row___uK4C row"><div class="StudyOverview_Col__Ho7wa StudyOverview_largeCol__J7XDJ col"><div tabindex="0" id="1" aria-label="Study Details collapsable section" class=" StudyOverview_accordion__xGdM_ undefined accordion"><div class="undefined Accordion_dataItem__pZkIy accordion-item"><h2 class="undefined Accordion_dataHeader__8IWP_ accordion-header"><button type="button" aria-expanded="false" class="accordion-button collapsed"><svg width="18" height="10" viewBox="0 0 22 10" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M1 1.49609L10.8765 8.63072L21 1.49609" stroke="currentColor" stroke-width="2"></path></svg>Study Details</button></h2><div class="accordion-collapse collapse"><div class="undefined Accordion_dataBody__qQzXM accordion-body"><div class="StudyOverview_detailsListContainer__vV7es"><div class="StudyOverview_detailsList__jFVUF"><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Research Area</div><div><p>Liver Disease, Endocrine Diseases & Metabolic Diseases, Pancreatic Disease</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Study Type</div><div><p>Observational</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Study Sites</div><div><p>8</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Study Start Date</div><div><p>2017-01</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Study End Date</div><div><p>2019-12</p></div></div></div><div class="StudyOverview_detailsList__jFVUF"><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Condition</div><div><p>Fibrotic Liver Disease, Pancreatic Insufficiency, Cystic Fibrosis</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Clinical Trials URL</div><div class="StudyOverview_wordBreak__n5aYp"><p><a href="https://clinicaltrials.gov/ct2/show/NCT02979340" target="_blank" rel="noopener noreferrer">https://clinicaltrials.gov/ct2/show/NCT02979340</a></p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Study Website</div><div class="StudyOverview_wordBreak__n5aYp"><p><a href="https://childrennetwork.org/Clinical-Studies" target="_blank" rel="noopener noreferrer">https://childrennetwork.org/Clinical-Studies</a></p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">Keywords</div><div><p>Magnetic Resonance Imaging (MRI), Liver Stiffness Measurement (LSM), Cystic Fibrosis (CF), Liver Fibrosis, CFLD PUSH Ancillary Study, Magnetic Resonance Elastography</p></div></div><div class="StudyOverview_section__kATqU"><div class="StudyOverview_sectionTitle__m4Z_f">NIDDK Division</div><div><p>Division of Digestive Diseases and Nutrition</p></div></div></div></div></div></div></div></div></div></div><div class="StudyOverview_Row___uK4C row"><div class="StudyOverview_Col__Ho7wa StudyOverview_smallCol__ElwmY col"><div tabindex="0" id="1" aria-label="Study Population collapsable section" class=" StudyOverview_accordion__xGdM_ undefined accordion"><div class="undefined Accordion_dataItem__pZkIy accordion-item"><h2 class="undefined Accordion_dataHeader__8IWP_ accordion-header"><button type="button" aria-expanded="false" class="accordion-button collapsed"><svg width="18" height="10" viewBox="0 0 22 10" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M1 1.49609L10.8765 8.63072L21 1.49609" stroke="currentColor" stroke-width="2"></path></svg>Study Population</button></h2><div class="accordion-collapse collapse"><div class="undefined Accordion_dataBody__qQzXM accordion-body"><div class="StudyOverview_section__kATqU"><div style="--children-count:3" class="HighchartsCharts_Row__Xnc9d row"><div class="HighchartsCharts_Col__tL81L HighchartsCharts_populationContainer__lQh_v col"><div class="HighchartsCharts_section__zzKnl HighchartsCharts_centerText__a_y4Q"><div class="HighchartsCharts_studyPopNumber__aGjwH">115</div><div class="HighchartsCharts_studyPopDescription__1j5UH">Participants</div><hr/><div class="HighchartsCharts_targetPop__veD08">Target Population</div><div>Children</div></div></div><div class="HighchartsCharts_Col__tL81L col"><div></div></div><div class="HighchartsCharts_Col__tL81L col"><div></div></div><div class="HighchartsCharts_Col__tL81L col"><div></div></div><div class="HighchartsCharts_Col__tL81L col"><div></div></div></div></div></div></div></div></div></div></div><div class="StudyOverview_Row___uK4C row"><div class="StudyOverview_Col__Ho7wa col"><div tabindex="0" id="1" aria-label="Public Documents (9) collapsable section" class=" StudyOverview_accordion__xGdM_ undefined accordion"><div class="undefined Accordion_dataItem__pZkIy accordion-item"><h2 class="undefined Accordion_dataHeader__8IWP_ accordion-header"><button type="button" aria-expanded="false" class="accordion-button collapsed"><svg width="18" height="10" viewBox="0 0 22 10" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M1 1.49609L10.8765 8.63072L21 1.49609" stroke="currentColor" stroke-width="2"></path></svg>Public Documents (9)</button></h2><div class="accordion-collapse collapse"><div class="undefined Accordion_dataBody__qQzXM accordion-body"><div><div class="Table_spaceBetween__8htMZ"><button aria-label="Expand All Rows" class="Button_button__OFOdO Button_auto__peQWd Table_expandCollapseBtn__6RnKT Button_primary__WTwSy a a-primary">Expand All Rows</button><div><button aria-label="Download All Public Documents" class="Button_button__OFOdO Button_auto__peQWd Button_primary__WTwSy a a-primary">Download All Public Documents</button></div></div><div tabindex="0" class="StudyOverview_tableContainer__8p4vy Table_narrowPadding__nEChe Table_container__Y2W_q Table_offWhite__TTPPQ"><table role="table" class="Table_table__b_0YI table table-sm table-striped table-bordered"><caption class="sr-only">Public Documents Table</caption><thead><tr><th tabindex="0" colSpan="1" style="width:320px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_textHeader__nU1f7">Document Name</div></div></th><th tabindex="0" colSpan="1" style="width:300px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_textHeader__nU1f7">Description</div></div></th><th tabindex="0" colSpan="1" style="width:180px" class=""><div class=""><div class="Table_textHeader__nU1f7">Document Type</div></div></th><th tabindex="0" colSpan="1" style="width:120px" class=""><div class=""><div class="Table_textHeader__nU1f7">File Format</div></div></th><th tabindex="0" colSpan="1" style="width:130px" class=""><div class=""><div class="Table_textHeader__nU1f7">Compliance</div></div></th><th tabindex="0" colSpan="1" style="width:120px" class=""><div class=""><div class="Table_textHeader__nU1f7">Download</div></div></th></tr></thead><tbody><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Codebook/Data Dictionary</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "><span></span></td><td tabindex="0" class=" "><span></span></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Bibliography</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "><span></span></td><td tabindex="0" class=" "><span></span></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Dataset Integrity Check</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "><span></span></td><td tabindex="0" class=" "><span></span></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Data Collection Instruments/Forms</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "><span></span></td><td tabindex="0" class=" "><span></span></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Manual of Operations/Procedures</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "><span></span></td><td tabindex="0" class=" "><span></span></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div class="StudyOverview_folderFileContainer__zCz7b"><button aria-expanded="false" class="StudyOverview_folderButton__dFfKY"><div class="StudyOverview_branchIcon__PA8fm"><svg width="25" height="25" viewBox="0 0 56 48" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M51 11H11C8.24 11 6 13.24 6 16V40H4V15C4 11.69 6.69 9 10 9H49.86C49.41 7.28 47.86 6 46 6H21.83C21.56 6 21.31 5.89 21.12 5.71L16.29 0.88C15.73 0.32 14.96 0 14.17 0H5C2.24 0 0 2.24 0 5V44C0 46.21 1.79 48 4 48H51C53.76 48 56 45.76 56 43V16C56 13.24 53.76 11 51 11Z" fill="#437b83"></path></svg></div><div class="StudyOverview_fileName___Ooh0"><div>Study Protocol</div><div class="StudyOverview_rotate__OPFqY"><svg xmlns="http://www.w3.org/2000/svg" width="16" height="16" fill="currentColor" class="bi bi-chevron-up" viewBox="0 0 16 16"><path fill-rule="evenodd" d="M7.646 4.646a.5.5 0 0 1 .708 0l6 6a.5.5 0 0 1-.708.708L8 5.707l-5.646 5.647a.5.5 0 0 1-.708-.708z"></path></svg></div></div></button></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l "><span></span></td><td tabindex="0" class=" "><span></span></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td><td tabindex="0" class=" "></td></tr></tbody></table></div></div></div></div></div></div></div></div><div class="StudyOverview_Row___uK4C row"><div class="StudyOverview_Col__Ho7wa col"><div tabindex="0" id="1" aria-label="Resources Available on Request collapsable section" class=" StudyOverview_accordion__xGdM_ undefined accordion"><div class="undefined Accordion_dataItem__pZkIy accordion-item"><h2 class="undefined Accordion_dataHeader__8IWP_ accordion-header"><button type="button" aria-expanded="false" class="accordion-button collapsed"><svg width="18" height="10" viewBox="0 0 22 10" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M1 1.49609L10.8765 8.63072L21 1.49609" stroke="currentColor" stroke-width="2"></path></svg>Resources Available on Request</button></h2><div class="accordion-collapse collapse"><div class="undefined Accordion_dataBody__qQzXM accordion-body"><div class="StudyOverview_limitationsHeader__5inl0"><div class="StudyOverview_sectionTitle__m4Z_f">Permitted Use(s) of the Resources</div></div><div class="StudyOverview_limitationsContent__xd9A5"><ul><li>Use is allowed only for the specified disease(s), disorder(s), condition(s), or research area(s): Cystic Fibrosis Liver Disease</li></ul></div><div class="StudyOverview_nonPublicDocsHeader__5_TOJ"><div class="StudyOverview_sectionTitle__m4Z_f">Non-Public Documents (0)</div></div><div><div class="StudyOverview_noticeBox__SI9FL">There are currently no non-public documents available</div></div><div class="StudyOverview_datasetsHeader__eNhSK"><div class="StudyOverview_sectionTitle__m4Z_f">Datasets (5)</div></div><div><div class="Table_spaceBetween__8htMZ"><button aria-label="Expand All Rows" class="Button_button__OFOdO Button_auto__peQWd Table_expandCollapseBtn__6RnKT Button_primary__WTwSy a a-primary">Expand All Rows</button></div><div tabindex="0" class="StudyOverview_tableContainer__8p4vy Table_narrowPadding__nEChe Table_container__Y2W_q Table_offWhite__TTPPQ"><table role="table" class="Table_table__b_0YI table table-sm table-striped table-bordered"><caption class="sr-only">Datasets Table</caption><thead><tr><th tabindex="0" colSpan="1" style="width:320px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_textHeader__nU1f7">Dataset Name</div></div></th><th tabindex="0" colSpan="1" style="width:340px" class="Table_alignLeft__VdU8l"><div class=""><div class="Table_textHeader__nU1f7">Description</div></div></th><th tabindex="0" colSpan="1" style="width:120px" class=""><div class=""><div class="Table_textHeader__nU1f7"># of Records</div></div></th><th tabindex="0" colSpan="1" style="width:130px" class=""><div class=""><div class="Table_textHeader__nU1f7"># of Variables</div></div></th><th tabindex="0" colSpan="1" style="width:150px" class=""><div class=""><div class="Table_textHeader__nU1f7">File Format(s)</div></div></th></tr></thead><tbody><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div><div class="StudyOverview_folderFileContainer__zCz7b"><div class="StudyOverview_branchIcon__PA8fm" style="font-size:20px;color:#437b83"><svg width="20" height="25" viewBox="0 0 40 60" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M28.9461 8.47021V1.07812L38.3955 9.21047H29.6855C29.2778 9.21047 28.9461 8.87845 28.9461 8.47021Z" fill="#00A6BF"></path><path d="M2.50599 0.000402809H27.4481C27.4481 0.000402809 27.5274 -0.00481759 27.6285 0.0223285V8.47103C27.6285 9.60699 28.5515 10.531 29.6861 10.531H39.5203L39.8978 10.5331C39.9635 10.6208 40 10.7189 40 10.8943V53.8541C40 55.2396 38.8779 56.363 37.494 56.363H2.50599C1.12212 56.363 -9.53674e-07 55.2396 -9.53674e-07 53.8541V2.51037C-9.53674e-07 1.12383 1.12212 0.000402809 2.50599 0.000402809ZM28.4472 20.3809H11.5528C11.0554 20.3809 10.6507 20.7849 10.6507 21.284C10.6507 21.7831 11.0543 22.1871 11.5528 22.1871H28.4472C28.9446 22.1871 29.3493 21.7831 29.3493 21.284C29.3493 20.7849 28.9457 20.3809 28.4472 20.3809ZM5.97351 46.2187H34.0254C34.5229 46.2187 34.9275 45.8146 34.9275 45.3156C34.9275 44.8165 34.5239 44.4124 34.0254 44.4124H5.97351C5.47606 44.4124 5.07144 44.8165 5.07144 45.3156C5.07144 45.8146 5.47502 46.2187 5.97351 46.2187ZM5.07144 39.3079C5.07144 39.806 5.47502 40.2111 5.97351 40.2111H34.0254C34.5229 40.2111 34.9275 39.807 34.9275 39.3079C34.9275 38.8099 34.5239 38.4048 34.0254 38.4048H5.97351C5.47606 38.4048 5.07144 38.8089 5.07144 39.3079ZM5.97351 34.2024H34.0254C34.5229 34.2024 34.9275 33.7983 34.9275 33.2993C34.9275 32.8002 34.5239 32.3961 34.0254 32.3961H5.97351C5.47606 32.3961 5.07144 32.8002 5.07144 33.2993C5.07144 33.7983 5.47502 34.2024 5.97351 34.2024ZM5.97351 28.1947H34.0254C34.5229 28.1947 34.9275 27.7907 34.9275 27.2916C34.9275 26.7925 34.5239 26.3885 34.0254 26.3885H5.97351C5.47606 26.3885 5.07144 26.7925 5.07144 27.2916C5.07144 27.7907 5.47502 28.1947 5.97351 28.1947Z" fill="#2A796F"></path></svg></div> <div class="StudyOverview_fileName___Ooh0">PUSH MRE Central Dataset</div></div></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l ">Contains data from Form 28 (Central)</td><td tabindex="0" class=" ">93</td><td tabindex="0" class=" "><button aria-label="View Variables Table" class="Button_button__OFOdO Button_auto__peQWd StudyOverview_variablesButton__qz93B Button_primary__WTwSy a a-primary">34<span class="Button_iconRight__TBy6s"><svg width="22" height="10" viewBox="0 0 22 10" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M1 1.49609L10.8765 8.63072L21 1.49609" stroke="currentColor" stroke-width="2"></path></svg></span></button></td><td tabindex="0" class=" ">csv (15.58 KB); sas7bdat (128 KB)</td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div><div class="StudyOverview_folderFileContainer__zCz7b"><div class="StudyOverview_branchIcon__PA8fm" style="font-size:20px;color:#437b83"><svg width="20" height="25" viewBox="0 0 40 60" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M28.9461 8.47021V1.07812L38.3955 9.21047H29.6855C29.2778 9.21047 28.9461 8.87845 28.9461 8.47021Z" fill="#00A6BF"></path><path d="M2.50599 0.000402809H27.4481C27.4481 0.000402809 27.5274 -0.00481759 27.6285 0.0223285V8.47103C27.6285 9.60699 28.5515 10.531 29.6861 10.531H39.5203L39.8978 10.5331C39.9635 10.6208 40 10.7189 40 10.8943V53.8541C40 55.2396 38.8779 56.363 37.494 56.363H2.50599C1.12212 56.363 -9.53674e-07 55.2396 -9.53674e-07 53.8541V2.51037C-9.53674e-07 1.12383 1.12212 0.000402809 2.50599 0.000402809ZM28.4472 20.3809H11.5528C11.0554 20.3809 10.6507 20.7849 10.6507 21.284C10.6507 21.7831 11.0543 22.1871 11.5528 22.1871H28.4472C28.9446 22.1871 29.3493 21.7831 29.3493 21.284C29.3493 20.7849 28.9457 20.3809 28.4472 20.3809ZM5.97351 46.2187H34.0254C34.5229 46.2187 34.9275 45.8146 34.9275 45.3156C34.9275 44.8165 34.5239 44.4124 34.0254 44.4124H5.97351C5.47606 44.4124 5.07144 44.8165 5.07144 45.3156C5.07144 45.8146 5.47502 46.2187 5.97351 46.2187ZM5.07144 39.3079C5.07144 39.806 5.47502 40.2111 5.97351 40.2111H34.0254C34.5229 40.2111 34.9275 39.807 34.9275 39.3079C34.9275 38.8099 34.5239 38.4048 34.0254 38.4048H5.97351C5.47606 38.4048 5.07144 38.8089 5.07144 39.3079ZM5.97351 34.2024H34.0254C34.5229 34.2024 34.9275 33.7983 34.9275 33.2993C34.9275 32.8002 34.5239 32.3961 34.0254 32.3961H5.97351C5.47606 32.3961 5.07144 32.8002 5.07144 33.2993C5.07144 33.7983 5.47502 34.2024 5.97351 34.2024ZM5.97351 28.1947H34.0254C34.5229 28.1947 34.9275 27.7907 34.9275 27.2916C34.9275 26.7925 34.5239 26.3885 34.0254 26.3885H5.97351C5.47606 26.3885 5.07144 26.7925 5.07144 27.2916C5.07144 27.7907 5.47502 28.1947 5.97351 28.1947Z" fill="#2A796F"></path></svg></div> <div class="StudyOverview_fileName___Ooh0">PUSH MRE Eligibility Dataset</div></div></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l ">Contains data from Form 01D - MRE Eligibility</td><td tabindex="0" class=" ">126</td><td tabindex="0" class=" "><button aria-label="View Variables Table" class="Button_button__OFOdO Button_auto__peQWd StudyOverview_variablesButton__qz93B Button_primary__WTwSy a a-primary">24<span class="Button_iconRight__TBy6s"><svg width="22" height="10" viewBox="0 0 22 10" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M1 1.49609L10.8765 8.63072L21 1.49609" stroke="currentColor" stroke-width="2"></path></svg></span></button></td><td tabindex="0" class=" ">csv (15.82 KB); sas7bdat (128 KB)</td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div><div class="StudyOverview_folderFileContainer__zCz7b"><div class="StudyOverview_branchIcon__PA8fm" style="font-size:20px;color:#437b83"><svg width="20" height="25" viewBox="0 0 40 60" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M28.9461 8.47021V1.07812L38.3955 9.21047H29.6855C29.2778 9.21047 28.9461 8.87845 28.9461 8.47021Z" fill="#00A6BF"></path><path d="M2.50599 0.000402809H27.4481C27.4481 0.000402809 27.5274 -0.00481759 27.6285 0.0223285V8.47103C27.6285 9.60699 28.5515 10.531 29.6861 10.531H39.5203L39.8978 10.5331C39.9635 10.6208 40 10.7189 40 10.8943V53.8541C40 55.2396 38.8779 56.363 37.494 56.363H2.50599C1.12212 56.363 -9.53674e-07 55.2396 -9.53674e-07 53.8541V2.51037C-9.53674e-07 1.12383 1.12212 0.000402809 2.50599 0.000402809ZM28.4472 20.3809H11.5528C11.0554 20.3809 10.6507 20.7849 10.6507 21.284C10.6507 21.7831 11.0543 22.1871 11.5528 22.1871H28.4472C28.9446 22.1871 29.3493 21.7831 29.3493 21.284C29.3493 20.7849 28.9457 20.3809 28.4472 20.3809ZM5.97351 46.2187H34.0254C34.5229 46.2187 34.9275 45.8146 34.9275 45.3156C34.9275 44.8165 34.5239 44.4124 34.0254 44.4124H5.97351C5.47606 44.4124 5.07144 44.8165 5.07144 45.3156C5.07144 45.8146 5.47502 46.2187 5.97351 46.2187ZM5.07144 39.3079C5.07144 39.806 5.47502 40.2111 5.97351 40.2111H34.0254C34.5229 40.2111 34.9275 39.807 34.9275 39.3079C34.9275 38.8099 34.5239 38.4048 34.0254 38.4048H5.97351C5.47606 38.4048 5.07144 38.8089 5.07144 39.3079ZM5.97351 34.2024H34.0254C34.5229 34.2024 34.9275 33.7983 34.9275 33.2993C34.9275 32.8002 34.5239 32.3961 34.0254 32.3961H5.97351C5.47606 32.3961 5.07144 32.8002 5.07144 33.2993C5.07144 33.7983 5.47502 34.2024 5.97351 34.2024ZM5.97351 28.1947H34.0254C34.5229 28.1947 34.9275 27.7907 34.9275 27.2916C34.9275 26.7925 34.5239 26.3885 34.0254 26.3885H5.97351C5.47606 26.3885 5.07144 26.7925 5.07144 27.2916C5.07144 27.7907 5.47502 28.1947 5.97351 28.1947Z" fill="#2A796F"></path></svg></div> <div class="StudyOverview_fileName___Ooh0">PUSH MRE Local Dataset</div></div></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l ">Contains data from Form 28A (Local)</td><td tabindex="0" class=" ">93</td><td tabindex="0" class=" "><button aria-label="View Variables Table" class="Button_button__OFOdO Button_auto__peQWd StudyOverview_variablesButton__qz93B Button_primary__WTwSy a a-primary">46<span class="Button_iconRight__TBy6s"><svg width="22" height="10" viewBox="0 0 22 10" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M1 1.49609L10.8765 8.63072L21 1.49609" stroke="currentColor" stroke-width="2"></path></svg></span></button></td><td tabindex="0" class=" ">csv (16.7 KB); sas7bdat (768 KB)</td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div><div class="StudyOverview_folderFileContainer__zCz7b"><div class="StudyOverview_branchIcon__PA8fm" style="font-size:20px;color:#437b83"><svg width="20" height="25" viewBox="0 0 40 60" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M28.9461 8.47021V1.07812L38.3955 9.21047H29.6855C29.2778 9.21047 28.9461 8.87845 28.9461 8.47021Z" fill="#00A6BF"></path><path d="M2.50599 0.000402809H27.4481C27.4481 0.000402809 27.5274 -0.00481759 27.6285 0.0223285V8.47103C27.6285 9.60699 28.5515 10.531 29.6861 10.531H39.5203L39.8978 10.5331C39.9635 10.6208 40 10.7189 40 10.8943V53.8541C40 55.2396 38.8779 56.363 37.494 56.363H2.50599C1.12212 56.363 -9.53674e-07 55.2396 -9.53674e-07 53.8541V2.51037C-9.53674e-07 1.12383 1.12212 0.000402809 2.50599 0.000402809ZM28.4472 20.3809H11.5528C11.0554 20.3809 10.6507 20.7849 10.6507 21.284C10.6507 21.7831 11.0543 22.1871 11.5528 22.1871H28.4472C28.9446 22.1871 29.3493 21.7831 29.3493 21.284C29.3493 20.7849 28.9457 20.3809 28.4472 20.3809ZM5.97351 46.2187H34.0254C34.5229 46.2187 34.9275 45.8146 34.9275 45.3156C34.9275 44.8165 34.5239 44.4124 34.0254 44.4124H5.97351C5.47606 44.4124 5.07144 44.8165 5.07144 45.3156C5.07144 45.8146 5.47502 46.2187 5.97351 46.2187ZM5.07144 39.3079C5.07144 39.806 5.47502 40.2111 5.97351 40.2111H34.0254C34.5229 40.2111 34.9275 39.807 34.9275 39.3079C34.9275 38.8099 34.5239 38.4048 34.0254 38.4048H5.97351C5.47606 38.4048 5.07144 38.8089 5.07144 39.3079ZM5.97351 34.2024H34.0254C34.5229 34.2024 34.9275 33.7983 34.9275 33.2993C34.9275 32.8002 34.5239 32.3961 34.0254 32.3961H5.97351C5.47606 32.3961 5.07144 32.8002 5.07144 33.2993C5.07144 33.7983 5.47502 34.2024 5.97351 34.2024ZM5.97351 28.1947H34.0254C34.5229 28.1947 34.9275 27.7907 34.9275 27.2916C34.9275 26.7925 34.5239 26.3885 34.0254 26.3885H5.97351C5.47606 26.3885 5.07144 26.7925 5.07144 27.2916C5.07144 27.7907 5.47502 28.1947 5.97351 28.1947Z" fill="#2A796F"></path></svg></div> <div class="StudyOverview_fileName___Ooh0">PUSH MRE Visits Dataset</div></div></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l ">Captures visit level data from the MRE study</td><td tabindex="0" class=" ">99</td><td tabindex="0" class=" "><button aria-label="View Variables Table" class="Button_button__OFOdO Button_auto__peQWd StudyOverview_variablesButton__qz93B Button_primary__WTwSy a a-primary">8<span class="Button_iconRight__TBy6s"><svg width="22" height="10" viewBox="0 0 22 10" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M1 1.49609L10.8765 8.63072L21 1.49609" stroke="currentColor" stroke-width="2"></path></svg></span></button></td><td tabindex="0" class=" ">csv (7.05 KB); sas7bdat (128 KB)</td></tr><tr class="Table_noHover__d57mA"><td tabindex="0" class="Table_alignLeft__VdU8l "><div style="padding-left:0rem;word-break:break-word;overflow-wrap:break-word;white-space:pre-wrap"><div><div class="StudyOverview_folderFileContainer__zCz7b"><div class="StudyOverview_branchIcon__PA8fm" style="font-size:20px;color:#437b83"><svg width="20" height="25" viewBox="0 0 40 60" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M28.9461 8.47021V1.07812L38.3955 9.21047H29.6855C29.2778 9.21047 28.9461 8.87845 28.9461 8.47021Z" fill="#00A6BF"></path><path d="M2.50599 0.000402809H27.4481C27.4481 0.000402809 27.5274 -0.00481759 27.6285 0.0223285V8.47103C27.6285 9.60699 28.5515 10.531 29.6861 10.531H39.5203L39.8978 10.5331C39.9635 10.6208 40 10.7189 40 10.8943V53.8541C40 55.2396 38.8779 56.363 37.494 56.363H2.50599C1.12212 56.363 -9.53674e-07 55.2396 -9.53674e-07 53.8541V2.51037C-9.53674e-07 1.12383 1.12212 0.000402809 2.50599 0.000402809ZM28.4472 20.3809H11.5528C11.0554 20.3809 10.6507 20.7849 10.6507 21.284C10.6507 21.7831 11.0543 22.1871 11.5528 22.1871H28.4472C28.9446 22.1871 29.3493 21.7831 29.3493 21.284C29.3493 20.7849 28.9457 20.3809 28.4472 20.3809ZM5.97351 46.2187H34.0254C34.5229 46.2187 34.9275 45.8146 34.9275 45.3156C34.9275 44.8165 34.5239 44.4124 34.0254 44.4124H5.97351C5.47606 44.4124 5.07144 44.8165 5.07144 45.3156C5.07144 45.8146 5.47502 46.2187 5.97351 46.2187ZM5.07144 39.3079C5.07144 39.806 5.47502 40.2111 5.97351 40.2111H34.0254C34.5229 40.2111 34.9275 39.807 34.9275 39.3079C34.9275 38.8099 34.5239 38.4048 34.0254 38.4048H5.97351C5.47606 38.4048 5.07144 38.8089 5.07144 39.3079ZM5.97351 34.2024H34.0254C34.5229 34.2024 34.9275 33.7983 34.9275 33.2993C34.9275 32.8002 34.5239 32.3961 34.0254 32.3961H5.97351C5.47606 32.3961 5.07144 32.8002 5.07144 33.2993C5.07144 33.7983 5.47502 34.2024 5.97351 34.2024ZM5.97351 28.1947H34.0254C34.5229 28.1947 34.9275 27.7907 34.9275 27.2916C34.9275 26.7925 34.5239 26.3885 34.0254 26.3885H5.97351C5.47606 26.3885 5.07144 26.7925 5.07144 27.2916C5.07144 27.7907 5.47502 28.1947 5.97351 28.1947Z" fill="#2A796F"></path></svg></div> <div class="StudyOverview_fileName___Ooh0">PUSH MRE Demographics Dataset</div></div></div></div></td><td tabindex="0" class="Table_alignLeft__VdU8l ">Contains demographics data captured from CFLD PUSH study linked to participants in the MRE study</td><td tabindex="0" class=" ">115</td><td tabindex="0" class=" "><button aria-label="View Variables Table" class="Button_button__OFOdO Button_auto__peQWd StudyOverview_variablesButton__qz93B Button_primary__WTwSy a a-primary">9<span class="Button_iconRight__TBy6s"><svg width="22" height="10" viewBox="0 0 22 10" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M1 1.49609L10.8765 8.63072L21 1.49609" stroke="currentColor" stroke-width="2"></path></svg></span></button></td><td tabindex="0" class=" ">csv (5.57 KB); sas7bdat (128 KB)</td></tr></tbody></table></div></div></div></div></div></div></div></div></div></div><footer 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Analysis of Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis Cohort Using Advanced MRI to Characterize and Predict CF Liver Disease (PUSH-MRE) (Version 1) [Dataset] NIDDK Central Repository. "],"label":"Citation"},{"propertyValue":["Data from the Analysis of Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis Cohort Using Advanced MRI to Characterize and Predict CF Liver Disease (PUSH-MRE) [(Version 1) ] reported here are available for request at the NIDDK Central Repository (NIDDK-CR) website, Resources for Research (R4R), https://repository.niddk.nih.gov/."],"label":"Data Availability Statement"},{"propertyValue":["The PUSH-MRE study was conducted by the study investigators and supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The resources from the PUSH-MRE study reported here were supplied by NIDDK Central Repository (NIDDK-CR) and are available for request at https://repository.niddk.nih.gov. This manuscript was not prepared under the auspices of the PUSH-MRE study and does not necessarily reflect the opinions or views of the PUSH-MRE study, NIDDK-CR, or NIDDK.\""],"label":"Acknowledgement Statement"},{"propertyValue":["Version 1 (Updated on: Jan 09, 2025)"],"label":"Data Package Version"}],"Resource":[{"propertyValue":["Data Available for Request"],"label":"has data"},{"propertyValue":["Specimens Not Available"],"label":"specimen availability"}],"Limitations":[{"propertyValue":["Use is allowed only for the specified disease(s), disorder(s), condition(s), or research area(s): Cystic Fibrosis Liver Disease"],"label":"Permitted Use(s) of the Resources"}],"Population":[{"propertyValue":["Children"],"label":"Target Population"}],"Hidden":[{"propertyValue":["177"],"label":"Network ID"},{"propertyValue":["push-mre"],"label":"slug"}],"Title":[{"propertyValue":["Analysis of Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis Cohort Using Advanced MRI to Characterize and Predict CF Liver Disease"],"label":"Study Name"},{"propertyValue":["PUSH-MRE"],"label":"Study Acronym"},{"propertyValue":["ChiLDReN Network (ChiLDReN)"],"label":"Network"}],"Representative":[{"propertyValue":["The Analysis of Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis Cohort Using Advanced MRI to Characterize and Predict CF Liver Disease (PUSH-MRE) study was a prospective cross sectional ancillary study of children and adolescents with cystic fibrosis enrolled in the Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis Liver Disease (CFLD PUSH) study. PUSH-MRE sought to determine the feasibility of MRI and magnetic resonance elastography (MRE) to predict the development of advanced liver disease in children and adolescents with CF. Participants were a subset to those enrolled in the CFLD PUSH study, at 8 of the 11 centers that had research MRE capability. \nThis study is an ancillary study to the CFLD PUSH study. If requesting access to the PUSH-MRE data, it is recommended to also request access to the CFLD PUSH data to obtain comprehensive information collected on study participants."],"label":"General Description"},{"propertyValue":["The primary objectives were to:\n\n- Determine the feasibility of unsedated MRI/MRE assessments of liver stiffness and hepatic lipid content in children and adolescents with CF\n- Determine hepatic lipid content using HepaFat and liver stiffness by MRE compared to ultrasound data and vibration controlled transient elastography in the same cohort\n\nThe secondary objectives were to:\n\n- Develop an imaging core to centralize MR imaging data\n- Determine the correlation between local MRE and MRI interpretation and central interpretation\n- Assess if MRI imaging data improves the discrimination of those participants at risk for advanced CF liver disease (as determined by ultrasound nodular pattern)"],"label":"Objectives"},{"propertyValue":["Outcome measures included changes over time in liver stiffness and lipid content using MRE. Analysis of variance (ANOVA) was used to compare the distribution of liver stiffness (in kPa) and lipid content measures between all groups defined by the CFLD PUSH study grayscale ultrasound results over time."],"label":"Outcome Measure"},{"propertyValue":["Inclusion criteria:\n\n- Participation in the CFLD PUSH study which enrolled children aged 3 through 12 years of age diagnosed with cystic fibrosis and pancreatic insufficiency\n- At a center with MRI/MRE capability\n- Able to perform unsedated MRI for 10-20 minutes\n- Signed informed consent and if appropriate assent\n\nExclusion criteria:\n\n- Initial exclusion criteria for the CFLD PUSH study such as known cirrhosis prior to screening, presence of Burkholderia cepacian, short bowel syndrome, and presence of other serious disease preventing participation\n- Inability to comply with longitudinal follow-up of the CFLD PUSH study\n- Contraindication to MRI"],"label":"Eligibility Criteria"},{"propertyValue":["There were 93 participants (51 females [54.8%]; mean 15.6 years [range 8.1–21.7 years]) that underwent MRI, in which MR elastography was feasible for 87 participants (93.5%), and 58 participants had an ultrasound within 1 year of MRI. In these participants, a nodular liver had significantly higher stiffness (p \u003c 0.01) than normal or homogeneous hyperechoic livers. Participants with a homogeneous hyperechoic liver had a higher fat fraction (p \u003c 0.005) than others."],"label":"Outcome"}],"Detail":[{"propertyValue":["Liver Disease","Endocrine Diseases \u0026 Metabolic Diseases","Pancreatic Disease"],"label":"Research Area"},{"propertyValue":["Observational"],"label":"Study Type"},{"propertyValue":["8"],"label":"Study Sites"},{"propertyValue":["2017-01"],"label":"Study Start Date"},{"propertyValue":["2019-12"],"label":"Study End Date"},{"propertyValue":["Fibrotic Liver Disease","Pancreatic Insufficiency","Cystic Fibrosis"],"label":"Condition"},{"propertyValue":["https://clinicaltrials.gov/ct2/show/NCT02979340"],"label":"Clinical Trials URL"},{"propertyValue":["https://childrennetwork.org/Clinical-Studies"],"label":"Study Website"},{"propertyValue":["Magnetic Resonance Imaging (MRI)","Liver Stiffness Measurement (LSM)","Cystic Fibrosis (CF)","Liver Fibrosis","CFLD PUSH Ancillary Study","Magnetic Resonance Elastography"],"label":"Keywords"},{"propertyValue":["Division of Digestive Diseases and Nutrition"],"label":"NIDDK Division"}]},"pubCount":0,"publicDocs":{"documents":{"Codebook/Data Dictionary":[{"id":16617,"filePath":"PUSH_MRE_V1/Documents/CFLDLink_MRE_SAF_Data_Dictionary.xlsx","title":"CFLD Link MRE Data Dictionary ","description":"Data Dictionary used as a collection of metadata - defines the variable contents of each dataset ","format":"xlsx","size":21390,"compliance":"Non-Compliant","displayOrder":30},{"id":16620,"filePath":"PUSH_MRE_V1/Documents/PUSH_MRE_Data_Dictionary_V1.pdf","title":"PUSH MRE Data Dictionary","description":"Data Dictionary used as a collection of metadata - defines the variable contents of each dataset (V1)","format":"pdf","size":144815,"compliance":"Non-Compliant","displayOrder":60}],"Bibliography":[{"id":16618,"filePath":"PUSH_MRE_V1/Documents/PUSH_MRE_Bibliography.pdf","title":"PUSH MRE Bibliography","description":"List of published manuscripts and presentations associated with PUSH MRE ","format":"pdf","size":30855,"compliance":"Non-Compliant","displayOrder":40}],"Dataset Integrity Check":[{"id":16619,"filePath":"PUSH_MRE_V1/Documents/PUSH_MRE_DSIC.pdf","title":"Dataset Integrity Check (Towbin et al., 2023)","description":"Dataset Integrity Check (DSIC) performed to replicate the results for the data in the publication by Towbin et al. 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