CINXE.COM

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<section> <a id="main-content"></a> <div class="region region-content"> <section id="block-system-main" class="block block-system clearfix">  <div class="row"> <div id="cm_menu" class="categories-left col-xs-12 col-sm-4 col-md-3"> <div class="mobile_facet_wrapper"> <div class="search_mobile_buttons"> <div class="cm_toggle btn btn-tertiary">Back to Cell Markers </div> </div> <div class="categories-menublock"> <h5>Cell Marker Categories</h5> <ul> <li class="active" ><a href="/resources/cell-markers/immune-cells" ><span>Immune Cells</span></a> <ul> <li class=""><a href="/resources/cell-markers/immune-cells/b-cells"><span>B Cells</span></a></li><li class=""><a href="/resources/cell-markers/immune-cells/dendritic-cells"><span>Dendritic Cells</span></a></li><li class="active"><a href="/resources/cell-markers/immune-cells/granulocytes"><span>Granulocytes</span></a></li><li class=""><a href="/resources/cell-markers/immune-cells/helper-t-cells"><span>Helper T Cells</span></a></li><li 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</div> <div class="categories-sidebar"> <div class="distributor_region"></div> <div id="sidebar"><div class="widget"> <div class="widget_title">R&D Systems Guarantee</div> <div class="widget_content" id="guarantee_area"> <div class="row"> <div class="guarantee_left col-xs-6 col-sm-12 col-lg-6"> <a href="/guarantee"><img loading="lazy" class="guarantee_image" alt="Product Performance Pledge" src="//resources.rndsystems.com/images/site/rndguarantee.png"></a> </div> <div class="guarantee_right col-xs-6 col-sm-12 col-lg-6"> <p>We offer a 100% guarantee on all our products.</p> <a class="btn btn-secondary" href="/guarantee">Learn More</a> </div> </div> </div> </div></div> </div> </div> </div> <div class="categories-right col-xs-12 col-sm-8 col-md-9"> <div class="search_mobile_buttons"> <div class="cm_menu_toggle btn btn-tertiary">Show Categories</div> </div> <div class="categories-header"> <h1>Basophil Cell Markers</h1>   <div class="cm_interactive_wrapper"> <p>Click on one of the cell types shown in the buttons below to see the human and mouse markers commonly used to identify the different types of granulocytes.</p> <style type="text/css"> .data {margin-bottom:15px;} .data div {display:block; position:relative; margin-bottom:15px;} .data > .col-xs-12.col-sm-3 {clear: both;} .data a, .data img {cursor:pointer} </style> <div class="datasheet_section_element"> <a class="btn btn-primary active" href="#">Basophil</a> <a class="btn btn-quaternary" href="/resources/cell-markers/immune-cells/granulocytes/eosinophil-cell-markers">Eosinophil</a> <a class="btn btn-quaternary" href="/resources/cell-markers/immune-cells/granulocytes/mast-cell-markers">Mast Cell</a> <a class="btn btn-quaternary" href="/resources/cell-markers/immune-cells/granulocytes/neutrophil-cell-markers">Neutrophil</a> </div> <div class="cm_interactive_content"> <div id="pw-map"> <div class="row"> <img src="https://resources.rndsystems.com/images/cellmarkers/cellmarker-images/basophil-bg.jpg?t=2" itemprop="contentUrl" alt="Property title" title="R&D Systems Cell Markers : Property title" draggable="false" ondragstart="return false;" /> </div> <div id="el1_gry" class="human_basophil_cell_markers pw-label2 el-gray1 pw-gray" style="top:110px; left:45px; "><strong>Human</strong></div><div id="el1_off" data-id="1" data-set="Human" data-type="" class="human_basophil_cell_markers pw-label2 el-off1" style="top:110px;left:45px;"><strong>Human</strong></div><div id="el2_gry" class="human_basophil_cell_markers pw-label2 el-gray2 pw-gray" style="top:150px; left:45px; "><strong>Cell Surface Markers</strong></div><div id="el2_off" data-id="2" data-set="CellSurfaceMarkers" data-type="" class="human_basophil_cell_markers pw-label2 el-off2" style="top:150px;left:45px;"><strong>Cell Surface Markers</strong></div><div id="el3_gry" class="human_basophil_cell_markers pw-label el-gray3 pw-gray" style="top:170px; left:45px; ">Lin<sup>-</sup></div><div id="el3_off" data-id="3" data-set="Lin" data-type="Click" class="human_basophil_cell_markers pw-label el-off3" style="top:170px;left:45px;">Lin<sup>-</sup></div> <div id="el3_ct" class="pw-tooltip" data-id="3"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/cd3?category=Primary%20Antibodies>CD3-</a><br><a href=/target/cd14?category=Primary%20Antibodies>CD14-</a><br><a href=/target/fc-gamma-riii-cd16?category=Primary%20Antibodies>CD16/Fc gamma RIII-</a><br><a href=/target/cd19?category=Primary%20Antibodies>CD19-</a><br><a href=/target/ncam-1-cd56?category=Primary%20Antibodies>NCAM-1/CD56-</a><br> <em><span style="color:#444;">A note regarding </span><a href="/resources/cell-markers/immune-cells/innate-lymphoid-cells/lineage-negative--lin----markers-note" target="_blank">Lin- Markers</a></em> </div> </div><div id="el4_gry" class="human_basophil_cell_markers pw-label el-gray4 pw-gray" style="top:190px; left:45px; ">CCR3<sup>+</sup></div><div id="el4_off" data-id="4" data-set="CCR3-h" data-type="Click" class="human_basophil_cell_markers pw-label el-off4" style="top:190px;left:45px;">CCR3<sup>+</sup></div> <div id="el4_ct" class="pw-tooltip" data-id="4"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/ccr3?category=Primary%20Antibodies>CCR3</a><br> </div> </div><div id="el5_gry" class="human_basophil_cell_markers pw-label el-gray5 pw-gray" style="top:210px; left:45px; ">CD11c<sup>+</sup></div><div id="el5_off" data-id="5" data-set="CD11c" data-type="Click" class="human_basophil_cell_markers pw-label el-off5" style="top:210px;left:45px;">CD11c<sup>+</sup></div> <div id="el5_ct" class="pw-tooltip" data-id="5"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/cd11c?category=Primary%20Antibodies>CD11c</a><br> </div> </div><div id="el6_gry" class="human_basophil_cell_markers pw-label el-gray6 pw-gray" style="top:230px; left:45px; ">CD22/Siglec-2<sup>+</sup></div><div id="el6_off" data-id="6" data-set="Siglec-2CD22" data-type="Click" class="human_basophil_cell_markers pw-label el-off6" style="top:230px;left:45px;">CD22/Siglec-2<sup>+</sup></div> <div id="el6_ct" class="pw-tooltip" data-id="6"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/siglec-2-cd22?category=Primary%20Antibodies>Siglec-2/CD22</a><br> </div> </div><div id="el7_gry" class="human_basophil_cell_markers pw-label el-gray7 pw-gray" style="top:250px; left:45px; ">CD45<sup>low</sup></div><div id="el7_off" data-id="7" data-set="CD45" data-type="Click" class="human_basophil_cell_markers pw-label el-off7" style="top:250px;left:45px;">CD45<sup>low</sup></div> <div id="el7_ct" class="pw-tooltip" data-id="7"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/cd45?category=Primary%20Antibodies>CD45</a><br> </div> </div><div id="el8_gry" class="human_basophil_cell_markers pw-label el-gray8 pw-gray" style="top:270px; left:45px; ">CD69<sup>+</sup></div><div id="el8_off" data-id="8" data-set="CD69" data-type="Click" class="human_basophil_cell_markers pw-label el-off8" style="top:270px;left:45px;">CD69<sup>+</sup></div> <div id="el8_ct" class="pw-tooltip" data-id="8"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/cd69?category=Primary%20Antibodies>CD69</a><br> </div> </div><div id="el9_gry" class="human_basophil_cell_markers pw-label el-gray9 pw-gray" style="top:290px; left:45px; ">CD117/c-kit<sup>-</sup></div><div id="el9_off" data-id="9" data-set="CD117c-kit" data-type="Click" class="human_basophil_cell_markers pw-label el-off9" style="top:290px;left:45px;">CD117/c-kit<sup>-</sup></div> <div id="el9_ct" class="pw-tooltip" data-id="9"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/cd117-c-kit?category=Primary%20Antibodies>CD117/c-kit</a><br> </div> </div><div id="el10_gry" class="human_basophil_cell_markers pw-label el-gray10 pw-gray" style="top:310px; left:45px; ">CRTH-2<sup>+</sup></div><div id="el10_off" data-id="10" data-set="CRTH-2" data-type="Click" class="human_basophil_cell_markers pw-label el-off10" style="top:310px;left:45px;">CRTH-2<sup>+</sup></div> <div id="el10_ct" class="pw-tooltip" data-id="10"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/crth-2?category=Primary%20Antibodies>CRTH-2</a><br> </div> </div><div id="el11_gry" class="human_basophil_cell_markers pw-label el-gray11 pw-gray" style="top:330px; left:45px; ">ENPP-3/CD203c<sup>+</sup></div><div id="el11_off" data-id="11" data-set="ENPP-3CD203c" data-type="Click" class="human_basophil_cell_markers pw-label el-off11" style="top:330px;left:45px;">ENPP-3/CD203c<sup>+</sup></div> <div id="el11_ct" class="pw-tooltip" data-id="11"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/enpp-3-cd203c?category=Primary%20Antibodies>ENPP-3/CD203c</a><br> </div> </div><div id="el12_gry" class="human_basophil_cell_markers pw-label el-gray12 pw-gray" style="top:350px; left:45px; ">Fc epsilon RI alpha<sup>+</sup></div><div id="el12_off" data-id="12" data-set="FcepsilonRIalpha" data-type="Click" class="human_basophil_cell_markers pw-label el-off12" style="top:350px;left:45px;">Fc epsilon RI alpha<sup>+</sup></div> <div id="el12_ct" class="pw-tooltip" data-id="12"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/fc-epsilon-ri-alpha?category=Primary%20Antibodies>Fc epsilon RI alpha</a><br> </div> </div><div id="el13_gry" class="human_basophil_cell_markers pw-label el-gray13 pw-gray" style="top:370px; left:45px; ">HLA-DR<sup>-/low</sup> (inducible)</div><div id="el13_off" data-id="13" data-set="HLA-DR" data-type="Click" class="human_basophil_cell_markers pw-label el-off13" style="top:370px;left:45px;">HLA-DR<sup>-/low</sup> (inducible)</div> <div id="el13_ct" class="pw-tooltip" data-id="13"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/hla-dr?category=Primary%20Antibodies>HLA-DR</a><br> </div> </div><div id="el14_gry" class="human_basophil_cell_markers pw-label el-gray14 pw-gray" style="top:390px; left:45px; ">IL-3 R alpha/CD123<sup>high</sup></div><div id="el14_off" data-id="14" data-set="IL-3RalphaCD123" data-type="Click" class="human_basophil_cell_markers pw-label el-off14" style="top:390px;left:45px;">IL-3 R alpha/CD123<sup>high</sup></div> <div id="el14_ct" class="pw-tooltip" data-id="14"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/il-3-r-alpha-cd123?category=Primary%20Antibodies>IL-3 R alpha/CD123</a><br> </div> </div><div id="el15_gry" class="human_basophil_cell_markers pw-label el-gray15 pw-gray" style="top:410px; left:45px; ">Integrin alpha 2/CD49b<sup>+</sup></div><div id="el15_off" data-id="15" data-set="Integrinalpha2CD49b" data-type="Click" class="human_basophil_cell_markers pw-label el-off15" style="top:410px;left:45px;">Integrin alpha 2/CD49b<sup>+</sup></div> <div id="el15_ct" class="pw-tooltip" data-id="15"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/integrin-alpha-2-cd49b?category=Primary%20Antibodies>Integrin alpha 2/CD49b</a><br> </div> </div><div id="el16_gry" class="human_basophil_cell_markers pw-label2 el-gray16 pw-gray" style="top:300px; left:310px; "><strong>Intracellular Markers</strong></div><div id="el16_off" data-id="16" data-set="IntracellularMarkers" data-type="" class="human_basophil_cell_markers pw-label2 el-off16" style="top:300px;left:310px;"><strong>Intracellular Markers</strong></div><div id="el17_gry" class="human_basophil_cell_markers pw-label el-gray17 pw-gray" style="top:320px; left:310px; ">CEBP alpha<sup>+</sup></div><div id="el17_off" data-id="17" data-set="CEBPalpha" data-type="Click" class="human_basophil_cell_markers pw-label el-off17" style="top:320px;left:310px;">CEBP alpha<sup>+</sup></div> <div id="el17_ct" class="pw-tooltip" data-id="17"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/cebp-alpha?category=Primary%20Antibodies>CEBP alpha</a><br> </div> </div><div id="el18_gry" class="human_basophil_cell_markers pw-label el-gray18 pw-gray" style="top:340px; left:310px; ">2D7 Antigen<sup>+</sup> (human)</div><div id="el18_off" data-id="18" data-set="2D7Antigen" data-type="No Products Click" class="human_basophil_cell_markers pw-label el-off18" style="top:340px;left:310px;">2D7 Antigen<sup>+</sup> (human)</div> <div id="el18_ct" class="pw-tooltip" data-id="18"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><span style="color:black">We currently do not offer products for this molecule. Use our <a target="_blank" href="/products/product-suggestions?m=2D7%20Antigen%2B" rel="noreferrer">Product Suggestion form</a> to enter a request. You will be notified once it becomes available.</span> </div> </div><div id="el19_gry" class="mouse_basophil_cell_markers pw-label2 el-gray19 pw-gray" style="top:110px; left:540px; "><strong>Mouse</strong></div><div id="el19_off" data-id="19" data-set="Mouse" data-type="" class="mouse_basophil_cell_markers pw-label2 el-off19" style="top:110px;left:540px;"><strong>Mouse</strong></div><div id="el20_gry" class="mouse_basophil_cell_markers pw-label2 el-gray20 pw-gray" style="top:150px; left:540px; "><strong>Cell Surface Markers</strong></div><div id="el20_off" data-id="20" data-set="CellSurfaceMarkers" data-type="" class="mouse_basophil_cell_markers pw-label2 el-off20" style="top:150px;left:540px;"><strong>Cell Surface Markers</strong></div><div id="el21_gry" class="mouse_basophil_cell_markers pw-label el-gray21 pw-gray" style="top:170px; left:540px; ">Lin<sup>-</sup></div><div id="el21_off" data-id="21" data-set="Lin" data-type="Click" class="mouse_basophil_cell_markers pw-label el-off21" style="top:170px;left:540px;">Lin<sup>-</sup></div> <div id="el21_ct" class="pw-tooltip" data-id="21"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/b220-cd45r?category=Primary%20Antibodies>B220-</a><br><a href=/target/cd3?category=Primary%20Antibodies>CD3-</a><br><a href=/target/cd19?category=Primary%20Antibodies>CD19-</a><br><a href=/target/ly-6g-ly-6c-gr-1?category=Primary%20Antibodies>Gr-1-</a><br><a href=/target/cd161-nk1-1?category=Primary%20Antibodies>NK1.1-</a><br><a href=/target/ter-119?category=Primary%20Antibodies>TER-119-</a><br> <em><span style="color:#444;">A note regarding </span><a href="/resources/cell-markers/immune-cells/innate-lymphoid-cells/lineage-negative--lin----markers-note" target="_blank">Lin- Markers</a></em> </div> </div><div id="el22_gry" class="mouse_basophil_cell_markers pw-label el-gray22 pw-gray" style="top:190px; left:540px; ">CCR3<sup>+</sup></div><div id="el22_off" data-id="22" data-set="CCR3-m" data-type="Click" class="mouse_basophil_cell_markers pw-label el-off22" style="top:190px;left:540px;">CCR3<sup>+</sup></div> <div id="el22_ct" class="pw-tooltip" data-id="22"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/ccr3?category=Primary%20Antibodies>CCR3</a><br> </div> </div><div id="el23_gry" class="mouse_basophil_cell_markers pw-label el-gray23 pw-gray" style="top:210px; left:540px; ">CD11c<sup>-</sup></div><div id="el23_off" data-id="23" data-set="CD11c" data-type="Click" class="mouse_basophil_cell_markers pw-label el-off23" style="top:210px;left:540px;">CD11c<sup>-</sup></div> <div id="el23_ct" class="pw-tooltip" data-id="23"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/cd11c?category=Primary%20Antibodies>CD11c</a><br> </div> </div><div id="el24_gry" class="mouse_basophil_cell_markers pw-label el-gray24 pw-gray" style="top:230px; left:540px; ">CD45<sup>int</sup></div><div id="el24_off" data-id="24" data-set="CD45" data-type="Click" class="mouse_basophil_cell_markers pw-label el-off24" style="top:230px;left:540px;">CD45<sup>int</sup></div> <div id="el24_ct" class="pw-tooltip" data-id="24"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/cd45?category=Primary%20Antibodies>CD45</a><br> </div> </div><div id="el25_gry" class="mouse_basophil_cell_markers pw-label el-gray25 pw-gray" style="top:250px; left:540px; ">CD69<sup>+</sup></div><div id="el25_off" data-id="25" data-set="CD69" data-type="Click" class="mouse_basophil_cell_markers pw-label el-off25" style="top:250px;left:540px;">CD69<sup>+</sup></div> <div id="el25_ct" class="pw-tooltip" data-id="25"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/cd69?category=Primary%20Antibodies>CD69</a><br> </div> </div><div id="el26_gry" class="mouse_basophil_cell_markers pw-label el-gray26 pw-gray" style="top:270px; left:540px; ">CD117/c-kit<sup>-</sup></div><div id="el26_off" data-id="26" data-set="CD117c-kit" data-type="Click" class="mouse_basophil_cell_markers pw-label el-off26" style="top:270px;left:540px;">CD117/c-kit<sup>-</sup></div> <div id="el26_ct" class="pw-tooltip" data-id="26"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/cd117-c-kit?category=Primary%20Antibodies>CD117/c-kit</a><br> </div> </div><div id="el27_gry" class="mouse_basophil_cell_markers pw-label el-gray27 pw-gray" style="top:290px; left:540px; ">CD200R3<sup>+</sup></div><div id="el27_off" data-id="27" data-set="CD200R3" data-type="No Products Click" class="mouse_basophil_cell_markers pw-label el-off27" style="top:290px;left:540px;">CD200R3<sup>+</sup></div> <div id="el27_ct" class="pw-tooltip" data-id="27"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><span style="color:black">We currently do not offer products for this molecule. Use our <a target="_blank" href="/products/product-suggestions?m=CD200R3%2B" rel="noreferrer">Product Suggestion form</a> to enter a request. You will be notified once it becomes available.</span> </div> </div><div id="el28_gry" class="human_basophil_cell_markers pw-label el-gray28 pw-gray" style="top:310px; left:540px; ">CRTH-2<sup>+</sup></div><div id="el28_off" data-id="28" data-set="CRTH-2-m" data-type="Click" class="human_basophil_cell_markers pw-label el-off28" style="top:310px;left:540px;">CRTH-2<sup>+</sup></div> <div id="el28_ct" class="pw-tooltip" data-id="28"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/crth-2?category=Primary%20Antibodies>CRTH-2</a><br> </div> </div><div id="el29_gry" class="mouse_basophil_cell_markers pw-label el-gray29 pw-gray" style="top:330px; left:540px; ">ENPP-3/CD203c<sup>+</sup></div><div id="el29_off" data-id="29" data-set="ENPP-3CD203c" data-type="Click" class="mouse_basophil_cell_markers pw-label el-off29" style="top:330px;left:540px;">ENPP-3/CD203c<sup>+</sup></div> <div id="el29_ct" class="pw-tooltip" data-id="29"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/enpp-3-cd203c?category=Primary%20Antibodies>ENPP-3/CD203c</a><br> </div> </div><div id="el30_gry" class="mouse_basophil_cell_markers pw-label el-gray30 pw-gray" style="top:350px; left:540px; ">Fc epsilon RI alpha<sup>+</sup></div><div id="el30_off" data-id="30" data-set="FcepsilonRIalpha" data-type="Click" class="mouse_basophil_cell_markers pw-label el-off30" style="top:350px;left:540px;">Fc epsilon RI alpha<sup>+</sup></div> <div id="el30_ct" class="pw-tooltip" data-id="30"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/fc-epsilon-ri-alpha?category=Primary%20Antibodies>Fc epsilon RI alpha</a><br> </div> </div><div id="el31_gry" class="mouse_basophil_cell_markers pw-label el-gray31 pw-gray" style="top:370px; left:540px; ">IL-3 R alpha/CD123<sup>high</sup></div><div id="el31_off" data-id="31" data-set="IL-3RalphaCD123" data-type="Click" class="mouse_basophil_cell_markers pw-label el-off31" style="top:370px;left:540px;">IL-3 R alpha/CD123<sup>high</sup></div> <div id="el31_ct" class="pw-tooltip" data-id="31"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/il-3-r-alpha-cd123?category=Primary%20Antibodies>IL-3 R alpha/CD123</a><br> </div> </div><div id="el32_gry" class="mouse_basophil_cell_markers pw-label el-gray32 pw-gray" style="top:390px; left:540px; ">Integrin alpha 2/CD49b<sup>+</sup></div><div id="el32_off" data-id="32" data-set="Integrinalpha2CD49b" data-type="Click" class="mouse_basophil_cell_markers pw-label el-off32" style="top:390px;left:540px;">Integrin alpha 2/CD49b<sup>+</sup></div> <div id="el32_ct" class="pw-tooltip" data-id="32"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/integrin-alpha-2-cd49b?category=Primary%20Antibodies>Integrin alpha 2/CD49b</a><br> </div> </div><div id="el33_gry" class="mouse_basophil_cell_markers pw-label el-gray33 pw-gray" style="top:410px; left:540px; ">Integrin alpha 2b/CD41<sup>+</sup></div><div id="el33_off" data-id="33" data-set="Integrinalpha2bCD41" data-type="Click" class="mouse_basophil_cell_markers pw-label el-off33" style="top:410px;left:540px;">Integrin alpha 2b/CD41<sup>+</sup></div> <div id="el33_ct" class="pw-tooltip" data-id="33"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/integrin-alpha-2b-cd41?category=Primary%20Antibodies>Integrin alpha 2b/CD41</a><br> </div> </div><div id="el34_gry" class="mouse_basophil_cell_markers pw-label el-gray34 pw-gray" style="top:430px; left:540px; ">Integrin beta 7<sup>-</sup></div><div id="el34_off" data-id="34" data-set="Integrinbeta7" data-type="Click" class="mouse_basophil_cell_markers pw-label el-off34" style="top:430px;left:540px;">Integrin beta 7<sup>-</sup></div> <div id="el34_ct" class="pw-tooltip" data-id="34"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/integrin-beta-7?category=Primary%20Antibodies>Integrin beta 7</a><br> </div> </div><div id="el35_gry" class="mouse_basophil_cell_markers pw-label el-gray35 pw-gray" style="top:450px; left:540px; ">MHC class II<sup>-/low</sup> (inducible)</div><div id="el35_off" data-id="35" data-set="MHCclassII" data-type="Click" class="mouse_basophil_cell_markers pw-label el-off35" style="top:450px;left:540px;">MHC class II<sup>-/low</sup> (inducible)</div> <div id="el35_ct" class="pw-tooltip" data-id="35"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"><a href=/target/mhc-class-ii-i-a-i-e?category=Primary%20Antibodies>MHC class II</a><br> </div> </div> </div> </div>  </div> </div> <div class="cm_content"> <h2>Overview</h2> <p>Basophils represent less than 1% of circulating leukocytes and are rarely found in peripheral tissues, but they are thought to play a central role in allergen- and helminth-induced immune responses. Like mast cells, basophils arise from CD34<sup>+</sup> progenitor cells in the bone marrow, and upon activation induced by IgE-Fc epsilon RI receptor cross-linking, they degranulate and release histamine from cytoplasmic granules. Basophils are involved in defending the host against parasitic infections, but they are also thought to contribute to the pathogenesis of allergic inflammation in the skin, lungs, and intestine, anaphylaxis, and autoimmune and inflammatory disorders. In addition, it has recently been suggested that basophils may modulate B cell functions. While basophils and mast cells express a number of common cell surface markers, flow cytometry can be used to identify basophils based on their low side scatter properties along with high level expression of <a href="/target/il-3-r-alpha-cd123?category=Primary%20Antibodies">IL-3 R alpha/CD123</a> and lack of expression of <a href="/target/cd117-c-kit?category=Primary%20Antibodies">CD117/c-kit</a>. Other common basophil markers include <a href="/target/crth-2?category=Primary%20Antibodies">CRTH-2</a>, <a href="/target/ccr3?category=Primary%20Antibodies">CCR3</a>, <a href="/target/enpp-3-cd203c?category=Primary%20Antibodies">ENPP-3/CD203c</a>, <a href="/target/fc-epsilon-ri-alpha?category=Primary%20Antibodies">Fc epsilon RI</a>, <a href="/target/integrin-alpha-2-cd49b?category=Primary%20Antibodies">Integrin alpha 2/CD49b</a>, CD200 R3 in mouse, and the transcription factor, <a href="/target/cebp-alpha?category=Primary%20Antibodies">CEBP alpha</a>. Basophils also display dim/variable expression of <a href="/target/cd45?category=Primary%20Antibodies">CD45</a>, lack expression of <a href="/target/mhc-class-ii-i-a-i-e?category=Primary%20Antibodies">MHC class II</a> and lineage markers such as CD3 and CD19, and upregulate expression of <a href="/target/enpp-3-cd203c?category=Primary%20Antibodies">ENPP-3/CD203c</a> and CD63 following activation.</p> </div> </div> </div> </section> <section id="block-block-26" class="block block-block clearfix">  <div class="embeddedServiceInvitation" id="snapins_invite" aria-live="assertive" role="dialog" aria-atomic="true" style="display: none;"> <div class="embeddedServiceInvitationHeader" aria-labelledby="snapins_titletext" aria-describedby="snapins_bodytext" style="height: 48px;"> <img id="embeddedServiceAvatar" /> <span class="embeddedServiceTitleText" id="snapins_titletext">Need help?</span> <button type="button" id="closeInvite" class="embeddedServiceCloseIcon" aria-label="Exit 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