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class="grants-giving-overlay"><h1 class="secondary-dark text-align-center"><strong>Information für Fachkreise</strong></h1><h2 class="text-align-center">Über die Erkrankungen und unsere RNAi-Therapien</h2><p class="font-20 mb-32">Zu unseren RNAi-Therapeutika für die hereditäre Transthyretin-Amyloidose mit Polyneuropathie, die primäre Hyperoxalurie Typ 1 und die akute hepatische Porphyrie finden Sie hier eine Sammlung an Informationsmaterial, wissenschaftliche Studien, Grafiken zur weiteren Verwendung sowie Informationen zu den zugrunde liegenden Erkrankungen.</p><div class="docmentation-checker-section" id="docmentation_checker_section"><div class="img-cont"><img src="/sites/default/files/inline-images/doccheck-icon-option-1.svg" alt="" /></div><div class="content-cont"><p>Ein Teil der Information ist über einen DocCheck-Zugang geschützt. Bitte melden Sie sich an, um es anzuzeigen.</p><p><a class="docmentation-checker" href="#" id="docmentation_checker">EINLOGGEN ›</a></p></div></div></div></div>  </div> </div>  </div> <div class="field__item">     <div class="paragraph paragraph--type--body paragraph-id--138 paragraph--view-mode--default"> <div class="accordian-one-col mb-32"> <div class="description--component" style="width:970px; margin:auto; ">     <div class="clearfix text-formatted field field--name-field-body field--type-text-with-summary field--label-hidden field__item"><div class="accordion accordion-flush" id="accordionFlushhcp"><div class="accordion-item"><h2 class="accordion-header" id="flush-headingOne"><button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#flush-collapseOne" aria-expanded="false" aria-controls="flush-collapseOne"> Primäre Hyperoxalurie Typ 1 (PH1) </button></h2><div class="accordion-collapse collapse" id="flush-collapseOne" aria-labelledby="flush-headingOne" data-bs-parent="#accordionFlushhcp"><div class="accordion-body"><h3>Über die primäre Hyperoxalurie Typ 1 (PH1)</h3><p><a href="/sites/default/files/pdfs/PH1-GEAU-00002 PH1-Broschure - VISUAL.pdf" target="_blank">Broschüre zur primären Hyperoxalurie Typ 1 (PH1) ›</a> <span class="pdf-note">(Format: PDF)</span></p><p><a href="/sites/default/files/dc/PH1-DEU-00027 PH1 Disease Awareness Infographic for HCPs.pdf" target="_blank">Diagnosegrafik zur PH1 ›</a> <span class="pdf-note">(Format: PDF)</span></p><p><a href="/sites/default/files/pdfs/PH1-DEU-00076-Primäre-Hyperoxalurie-Typ-1-PH1.pdf" target="_blank">Diagnostikkarte zur PH1 ›</a> <span class="pdf-note">(Format: PDF)</span></p><h3 class="mt-32 mb-0">Informationen zum Produkt</h3><p><a class="doc_checker" href="#" data-docid="ph1_doc_1" data-doctype="PH1" target="_blank">OXLUMO® Dosing Guide ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" 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have-lock" style="white-space:nowrap;">PDF)<img src="/themes/custom/alnylam/images/doccheck-icon-option.svg" alt="" /></span></p><h3 class="mt-32 mb-0">Patientenunterstützung</h3><p><a href="/sites/default/files/pdfs/PH1-DEU-00046 MEIN HANDBUCH PH1.pdf" target="_blank">Patientenhandbuch Primäre Hyperoxalurie Typ 1 ›</a> <span class="pdf-note">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">PDF)</span></p><p><a href="/sites/default/files/pdfs/PH1-DEU-00047 LEBEN MIT PH1.pdf" target="_blank">Handbuch für Eltern betroffener Kinder ›</a> <span class="pdf-note">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">PDF)</span></p><h3 class="mt-32 mb-0">Mediathek & Bibliothek</h3><p><a class="doc_checker" href="#" data-docid="ph1_doc_5" data-doctype="PH1" target="_blank">OXLUMO® Video zum Wirkmechanismus ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">Video)<img src="/themes/custom/alnylam/images/doccheck-icon-option.svg" alt="" /></span></p><p><a href="https://capella.alnylam.com/wp-content/uploads/2023/11/ILLUMINATE-C-24M-Poster_ASN-2023.pdf" target="_blank">24-Month Results from ILLUMINATE-C Phase 3 Study of OXLUMO® (lumasiran) ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">Link)</span></p><p><a href="https://capella.alnylam.com/wp-content/uploads/2023/04/Efficacy-and-Safety-of-Lumasiran-for-Infants-and-Young-Children-with-Primary-Hyperoxaluria-Type-1-30-Month-Analysis-of-the-Phase-3-ILLUMINATE-B-Trial_Final.pdf" target="_blank">30-Month Results from ILLUMINATE-B Phase 3 Study of OXLUMO® (lumasiran) ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">Link)</span></p><p><a href="https://capella.alnylam.com/wp-content/uploads/2023/04/NKFILLUM-A36M4-6-23.pdf" target="_blank">36-Month Results from ILLUMINATE-A Phase 3 Study of OXLUMO® (lumasiran) ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">Link)</span></p><div class="content_bottom"><div class="widget_text widget widget_custom_html"><div class="textwidget custom-html-widget"><p style="text-align:right;"><span class="kontact" style="text-align:right;">OXL-DEU-00094 01.2024</span></p></div></div></div></div></div></div><div class="accordion-item"><h2 class="accordion-header" id="flush-headingTwo"><button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#flush-collapseTwo" aria-expanded="false" aria-controls="flush-collapseTwo"> Akute Hepatische Porphyrie (AHP) </button></h2><div class="accordion-collapse collapse" id="flush-collapseTwo" aria-labelledby="flush-headingTwo" data-bs-parent="#accordionFlushhcp"><div class="accordion-body"><h3>Über die akute hepatische Porphyrie (AHP)</h3><p><a href="/sites/default/files/pdfs/AS1-DEU-00252 Brochure Evaluating and longterm control of AHP.pdf" target="_blank">AHP: Empfehlungen zur klinischen Evaluierung und langfristigen Kontrolle ›</a> <span class="pdf-note">(Format: PDF)</span></p><p><a href="/sites/default/files/dc/AS1-DEU-00181 AHP Diagnose und Test Flyer.pdf" target="_blank">AHP Diagnose- und Testleitfaden ›</a> <span class="pdf-note">(Format: PDF)</span></p><p><a href="/sites/default/files/pdfs/AS1-GEAU-00017 AHP Urgency to treat - chronic kidney disease - Slide Deck.pdf" target="_blank">AHP und chronische Nierenerkrankung ›</a> <span class="pdf-note">(Format: PDF)</span></p><p><a href="/sites/default/files/pdfs/AS1-DEU-00249 AHP Specific Diagnostic Card Neuro.pdf" target="_blank">AHP und Neurologie (Speciality Card Neurology) ›</a> <span class="pdf-note">(Format: PDF)</span></p><h3 class="mt-32 mb-0">Produktinformation</h3><p><a class="doc_checker" href="#" data-docid="ahp_doc_1" data-doctype="AHP" target="_blank">GIVLAARI® und RNAi Wirkmechanismus ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">PDF)<img src="/themes/custom/alnylam/images/doccheck-icon-option.svg" alt="" /></span></p><p><a class="doc_checker" href="#" data-docid="ahp_doc_2" data-doctype="AHP" target="_blank">GIVLAARI® Produktbroschüre ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">PDF)<img src="/themes/custom/alnylam/images/doccheck-icon-option.svg" alt="" /></span></p><h3 class="mt-32 mb-0">Patientenunterstützung</h3><p><a class="doc_checker" href="#" data-docid="ahp_doc_3" data-doctype="AHP" target="_blank">Patientenbroschüre 'AHP und Ihre Therapie mit Givosiran'›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">PDF)<img src="/themes/custom/alnylam/images/doccheck-icon-option.svg" alt="" /></span></p><p><a class="doc_checker" href="#" data-docid="ahp_doc_4" data-doctype="AHP" target="_blank">Infobogen kurz: 'AHP und Ihre Therapie mit Givosiran ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">PDF)<img src="/themes/custom/alnylam/images/doccheck-icon-option.svg" alt="" /></span></p><p><a href="/sites/default/files/pdfs/AS1-DEU-00262 Doctor Discussion Guide AHP.pdf" target="_blank">Leitfaden für Patienten zur Vorbereitung eines Arzttermins ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">PDF)</span></p><p><a href="/sites/default/files/pdfs/AS1-DEU-00146 EU AHP Patient brochure - German translation.pdf" target="_blank">Broschüre über die akute hepatische Porphyrie (AHP) für Patienten ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">PDF)</span></p><p><a href="/sites/default/files/pdfs/AS1-GEAU-00021 Symptom Tracker - Visual.pdf" target="_blank">Symptomtagebuch für Patienten ›</a> <span class="pdf-note">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">PDF)</span></p><h3 class="mt-32 mb-0">Mediathek & Bibliothek</h3><p><a href="https://www.journal-of-hepatology.eu/article/S0168-8278(23)04933-4/fulltext" target="_blank">Phase 3 Results From ENVISION Study of GIVLAARI® (givosiran) Published in the Journal of Hepatology ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">Link)</span></p><div class="content_bottom"><div class="widget_text widget widget_custom_html"><div class="textwidget custom-html-widget"><p style="text-align:right;"><span class="kontact" style="text-align:right;">AS1-DEU-00323 01.2024</span></p></div></div></div></div></div></div><div class="accordion-item"><h2 class="accordion-header" id="flush-headingThree"><button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#flush-collapseThree" aria-expanded="false" aria-controls="flush-collapseThree"> hereditäre ATTR-Amyloidose (ATTRv oder hATTR) </button></h2><div class="accordion-collapse collapse" id="flush-collapseThree" aria-labelledby="flush-headingThree" data-bs-parent="#accordionFlushhcp"><div class="accordion-body"><h3>Über die Transthyretin-(ATTR)-Amyloidose</h3><p><a href="/sites/default/files/pdfs/TTR-DEU-00082 Red Flag Neurology ATTRv (05-2023).pdf" target="_blank">Neurologische Red Flags der Transthyretin-Amyoidose ›</a> <span class="pdf-note">(Format: PDF)</span></p><p><a href="/sites/default/files/pdfs/TTR-DEU-00081 Red Flag Cardio (05-2023).pdf" target="_blank">Kardiologische Red Flags der Transthyretin-Amyloidose ›</a> <span class="pdf-note">(Format: PDF)</span></p><p><a href="/sites/default/files/pdfs/TTR-DEU-00020 Diagnostic Flow Cardiology ATTRv.pdf" target="_blank">Diagnoseweg Kardiologie zur Transthyretin-Amyloidose ›</a> <span class="pdf-note">(Format: PDF)</span></p><p><a href="/sites/default/files/pdfs/TTR-DEU-00021 Diagnostic Flow Polyneuropathie ATTRv.pdf" target="_blank">Diagnoseweg Neurologie zur Transthyretin-Amyloidose ›</a> <span class="pdf-note">(Format: PDF)</span></p><p><a href="/sites/default/files/pdfs/TTR-DEU-00033 CIDP Mailing Booklet.pdf" target="_blank">Differenzialdiagnose: CIDP oder ATTRv-Amyloidose? ›</a> <span class="pdf-note">(Format: PDF)</span></p><p><a class="doc_checker" href="#" data-docid="attr_doc_1" data-doctype="ATTR" target="_blank">Transthyretin-Amyloidose im Video: Entstehung des pathogenen Transthyretins und des Amyloids ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">Video)<img src="/themes/custom/alnylam/images/doccheck-icon-option.svg" alt="" /></span></p><h3 class="mt-32 mb-0">Informationen zum Produkt</h3><p><a class="doc_checker" href="#" data-docid="attr_doc_2" data-doctype="ATTR" target="_blank">Alles über AMVUTTRA® und über den Wirkmechanismus ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">PDF)<img src="/themes/custom/alnylam/images/doccheck-icon-option.svg" alt="" /></span></p><p><a class="doc_checker" href="#" data-docid="attr_doc_3" data-doctype="ATTR" target="_blank">RNA-Interferenz und RNAi-Therapeutikum AMVUTTRA® - wie funktioniert das eigentlich? ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">PDF)<img src="/themes/custom/alnylam/images/doccheck-icon-option.svg" alt="" /></span></p><p><a class="doc_checker" href="#" data-docid="attr_doc_4" data-doctype="ATTR" target="_blank">HELIOS-A Studienzusammenfassung ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">PDF)<img src="/themes/custom/alnylam/images/doccheck-icon-option.svg" alt="" /></span></p><p><a class="doc_checker" href="#" data-docid="attr_doc_5" data-doctype="ATTR" target="_blank">Verordnungshilfe für Kardiologen - Diagnose ATTRv: und nun? ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">PDF)<img src="/themes/custom/alnylam/images/doccheck-icon-option.svg" alt="" /></span></p><p><a class="doc_checker" href="#" data-docid="attr_doc_6" data-doctype="ATTR" target="_blank">Study Highlights: Helios-A Zusammenfassung mit Experten-Interview ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">PDF)<img src="/themes/custom/alnylam/images/doccheck-icon-option.svg" alt="" /></span></p><p><a class="doc_checker" href="#" data-docid="attr_doc_7" data-doctype="ATTR" target="_blank">AMVUTTRA® Fertigspritze Verabreichung ›</a> <span class="pdf-note have-lock">(Format: </span><span class="pdf-note have-lock" style="white-space:nowrap;">PDF)<img 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